dc.creator | Lavrnja, Irena | |
dc.creator | Trifunović, Svetlana | |
dc.creator | Ajdžanović, Vladimir | |
dc.creator | Peković, Sanja | |
dc.creator | Bjelobaba, Ivana | |
dc.creator | Stojiljkovic, Mirjana | |
dc.creator | Milošević, Verica | |
dc.date.accessioned | 2016-05-23T11:00:39Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 0031-9384 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2245 | |
dc.description.abstract | Traumatic brain injury (TBI) represents a serious event with far
reaching complications, including pituitary dysfunction. Pars distalis
corticotropes (ACTH cells), that represent the active module of
hypothalamo-pituitary-adrenocortical axis, seem to be affected as well.
Since pituitary failure after TBI has been associated with
neurobehavioral impairments the aim of this study was to evaluate the
effects of TBI on recovery of motor functions, morphology and secretory
activity of ACTH cells in the pituitary of adult rats. Wistar male rats,
initially exposed to sensorimotor cortex ablation (SCA), were sacrificed
at the 2nd, 7th, 14th and 30th days post-surgery (dps). A beam walking
test was used to evaluate the recovery of motor functions. Pituitary
glands and blood were collected for morphological and hormonal analyses.
During the first two weeks post-injury increased recovery of locomotor
function was detected, reaching almost the control value at day 30. SCA
induces significant increase of pituitary weights compared to their
time-matched controls. The volume of ACTH-immunopositive cells was
reduced at the 7th dps, while at the 14th dps their volume was enlarged,
in comparison to corresponding sham controls. Volume density of ACTH
cells was increased only at 14th dps, while at day 30 this increase was
insignificant. The plasma level of ACTH transiently increased after the
injury. The most pronounced changes were observed at the 7th and 14th
dps, and were followed by decrease toward control levels at the 30th
dps. Thus, temporal changes in the hypothalamic-pituitary-adrenal axis
after traumatic brain injury appear to correlate with the recovery
process. (C) 2013 Elsevier Inc. All rights reserved. | en |
dc.description.sponsorship | Ministry of Education, Science and Technological Development of the
Republic of Serbia {[}III 41014, ON 173009] | |
dc.language | English | |
dc.rights | restrictedAccess | |
dc.source | Physiology & Behavior | |
dc.subject | Traumatic brain injury | |
dc.subject | Pituitary | |
dc.subject | Locomotor activity | |
dc.subject | Rat | |
dc.title | Sensorimotor cortex ablation induces time-dependent response of ACTH
cells in adult rats: Behavioral, immunohistomorphometric and hormonal
study | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Стојиљковиц, Мирјана; Лаврња, Ирена Ц.; Aјджановић, Владимир; Пековић, Сања; Милосевиц, Верица; Трифуновиц, Светлана; Бјелобаба, Ивана; | |
dc.citation.volume | 125 | |
dc.identifier.doi | 10.1016/j.physbeh.2013.11.005 | |
dc.identifier.scopus | 2-s2.0-84889684409 | |
dc.identifier.wos | 000331478700005 | |
dc.citation.spage | 30 | |
dc.citation.epage | 37 | |
dc.type.version | publishedVersion | en |
dc.citation.rank | M21 | |