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Investigation of key interactions between the second extracellular loop of dopamine D2 receptor and several hydroxy-N-{[2-(4-phenyl-piperaziny-1-yl)ethyl]phenyl}-nicotinamides
dc.creator | Šukalović, Vladimir | |
dc.creator | Šoškić, Vukić | |
dc.creator | Ignjatović, Đurđica | |
dc.creator | Andrić, Deana | |
dc.creator | Penjišević, Jelena | |
dc.creator | Kostić-Rajačić, Slađana | |
dc.date.accessioned | 2016-05-23T11:00:41Z | |
dc.date.available | 2016-05-23T11:00:41Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 0352-5139 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2255 | |
dc.description.abstract | The dopaminergic receptor system has been the focus for the development of new pharmacotherapeutic agents targeting a number of central nervous system related disorders, such as drug addiction, schizophrenia, depression, and Parkinson's disease, to name just a few. To date, the crystal structure for the human D2 receptor is not known, despite its vital function and importance as a therapeutic target. Herein, a recent advancement in the determination of key receptor ligand interactions for the available arylpiperazine-like ligands, using a D2 receptor model based on the crystal structure of the D3 receptor is presented. To determine key interactions responsible for high dopaminergic activity, computer-docking analysis was used together with experimental data. A total of 4 dopaminergic ligands showing moderate to high affinity were tested and the obtained results rationalized using ligand structures docked into the proposed D2 receptor model. | en |
dc.description.sponsorship | Ministry for Education, Science and Technological Development of the Republic of Serbia {[}172032] | |
dc.language | English | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Journal of the Serbian Chemical Society | |
dc.subject | arylpiperazine | |
dc.subject | G protein-coupled receptors | |
dc.subject | docking | |
dc.subject | molecular modeling | |
dc.title | Investigation of key interactions between the second extracellular loop of dopamine D2 receptor and several hydroxy-N-{[2-(4-phenyl-piperaziny-1-yl)ethyl]phenyl}-nicotinamides | en |
dc.type | article | |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Игњатовиц, Дјурдјица; Aндриц, Деана; Пењисевиц, Јелена; Сукаловиц, Владимир; Соскиц, Вукиц; Костиц-Рајациц, Сладјана; | |
dc.rights.holder | © 2014 by the Serbian Chemical Society | |
dc.citation.issue | 12 | |
dc.citation.volume | 79 | |
dc.identifier.doi | 10.2298/JSC140423070S | |
dc.identifier.scopus | 2-s2.0-84920829324 | |
dc.identifier.wos | 000348749400001 | |
dc.citation.spage | 1461 | |
dc.citation.epage | 1467 | |
dc.type.version | publishedVersion | en |
dc.identifier.fulltext | https://radar.ibiss.bg.ac.rs/bitstream/id/11740/0352-51391400070S.pdf | |
dc.citation.rank | M23 |