dc.creator | Maksimović-Ivanić, Danijela | |
dc.creator | Mojić, Marija | |
dc.creator | Bulatović, Mirna Z. | |
dc.creator | Radojkovic, Milica | |
dc.creator | Kuzmanovic, Milos | |
dc.creator | Ristic, Slobodan | |
dc.creator | Stošić-Grujičić, Stanislava | |
dc.creator | Miljković, Đorđe | |
dc.creator | Cavalli, Eugenio | |
dc.creator | Libra, Massimo | |
dc.creator | Fagone, Paolo | |
dc.creator | McCubrey, James | |
dc.creator | Nicoletti, Ferdinando | |
dc.creator | Mijatović, Sanja | |
dc.date.accessioned | 2016-05-23T11:00:56Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 1873-5835 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2353 | |
dc.description.abstract | Covalent attachment of NO to the first approved HIV protease inhibitor
Saquinavir (Saq-NO) expands the therapeutic potential of the original
drug. Apart from retained antiviral activity, the modified drug exerts
strong antitumor effects and lower toxicity. In the present study, we
have evaluated the sensitivity of different hematological malignancies
to Saq-NO. Saq-NO efficiently diminished the viability of Jurkat, Raji,
HL-60 and K562 cells. While Jurkat and Raji cells (established from
pediatric patients) displayed abrogated proliferative potential, HL-60
and K652 cells (originated from adults) exposed to Saq-NO treatment
underwent caspase dependent apoptosis. In addition, similar sensitivity
to Saq-NO was observed in mononuclear blood cells obtained from
pediatric patients with acute lymphoblastic leukemia (ALL) and adult
patients with acute myeloid leukemia (AML). Western blot analysis
indicated p70S6 kinase as a possible intracellular target of Saq-NO
action. Moreover, the addition of a NO moiety to Lopinavir resulted in
improved antitumor potential as compared to the parental compound,
suggesting that NO-derived HIV protease inhibitors are a potential new
source of anticancer drugs with unique mode of action. (C) 2015 Elsevier
Ltd. All rights reserved. | en |
dc.language | English | |
dc.rights | restrictedAccess | |
dc.source | Leukemia Research | |
dc.subject | Saquinavir | |
dc.subject | Saquinavir-NO | |
dc.subject | Acute lymphoid leukemia | |
dc.subject | Acute myeloid leukemia | |
dc.subject | p70S6 kinase | |
dc.title | The NO-modified HIV protease inhibitor as a valuable drug for
hematological malignancies: Role of p70S6K | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Ристиц, Слободан; Радојковиц, Милица; Стошић-Грујичић, Станислава Д.; Фагоне, Паоло; МцЦубреy, Јамес; Ницолетти, Фердинандо; Миљковић, Ђорђе М.; Булатовић, Мирна З.; Мојић, Марија К.; Максимовић, Данијела Д.; Мијатовић, Сања A.; Кузмановиц, Милос; Цавалли, Еугенио; Либра, Массимо; | |
dc.rights.holder | © 2015 Elsevier Ltd. | |
dc.citation.issue | 10 | |
dc.citation.volume | 39 | |
dc.identifier.doi | 10.1016/j.leukres.2015.06.013 | |
dc.identifier.scopus | 2-s2.0-84941315547 | |
dc.identifier.wos | 000363427600013 | |
dc.citation.spage | 1088 | |
dc.citation.epage | 1095 | |
dc.type.version | publishedVersion | en |