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Modulation of hepatic inflammation and energy-sensing pathways in the rat liver by high-fructose diet and chronic stress.
dc.creator | Veličković, Nataša | |
dc.creator | Teofilović, Ana | |
dc.creator | Ilić, Dragana | |
dc.creator | Đorđević, Ana | |
dc.creator | Vojnović-Milutinović, Danijela | |
dc.creator | Petrović, Snježana | |
dc.creator | Preitner, Frederic | |
dc.creator | Tappy, Luc | |
dc.creator | Matić, Gordana | |
dc.date | 2019-05-29 | |
dc.date.accessioned | 2018-06-07T08:11:43Z | |
dc.date.available | 2019-05-29 | |
dc.date.issued | 2018 | |
dc.identifier.uri | http://link.springer.com/10.1007/s00394-018-1730-1 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/3077 | |
dc.description.abstract | PURPOSE High-fructose consumption and chronic stress are both associated with metabolic inflammation and insulin resistance. Recently, disturbed activity of energy sensor AMP-activated protein kinase (AMPK) was recognized as mediator between nutrient-induced stress and inflammation. Thus, we analyzed the effects of high-fructose diet, alone or in combination with chronic stress, on glucose homeostasis, inflammation and expression of energy sensing proteins in the rat liver. METHODS In male Wistar rats exposed to 9-week 20% fructose diet and/or 4-week chronic unpredictable stress we measured plasma and hepatic corticosterone level, indicators of glucose homeostasis and lipid metabolism, hepatic inflammation (pro- and anti-inflammatory cytokine levels, Toll-like receptor 4, NLRP3, activation of NFκB, JNK and ERK pathways) and levels of energy-sensing proteins AMPK, SIRT1 and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α). RESULTS High-fructose diet led to glucose intolerance, activation of NFκB and JNK pathways and increased intrahepatic IL-1β, TNFα and inhibitory phosphorylation of insulin receptor substrate 1 on Ser307. It also decreased phospho-AMPK/AMPK ratio and increased SIRT1 expression. Stress alone increased plasma and hepatic corticosterone but did not influence glucose tolerance, nor hepatic inflammatory or energy-sensing proteins. After the combined treatment, hepatic corticosterone was increased, glucose tolerance remained preserved, while hepatic inflammation was partially prevented despite decreased AMPK activity. CONCLUSION High-fructose diet resulted in glucose intolerance, hepatic inflammation, decreased AMPK activity and reduced insulin sensitivity. Chronic stress alone did not exert such effects, but when applied together with high-fructose diet it could partially prevent fructose-induced inflammation, presumably due to increased hepatic glucocorticoids. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41009/RS// | |
dc.relation | SCOPES JRP (Grant no. IZ73ZO_152331) | |
dc.rights | embargoedAccess | |
dc.source | European Journal of Nutrition | |
dc.subject | AMP-activated protein kinase | |
dc.subject | Dietary fructose | |
dc.subject | Inflammation | |
dc.subject | Rat liver | |
dc.subject | Stress | |
dc.title | Modulation of hepatic inflammation and energy-sensing pathways in the rat liver by high-fructose diet and chronic stress. | en |
dc.type | article | en |
dc.rights.license | ARR | |
dcterms.abstract | Таппy, Луц; Војновић-Милутиновић, Данијела; Матић, Гордана; Ђорђевић, Aна; Илић, Драгана; Величковић, Наташа; Теофиловић, Aна; Петровић, Сњежана; Преитнер, Фредериц; | |
dc.rights.holder | © 2018 Springer-Verlag GmbH Germany, part of Springer Nature | |
dc.description.note | This is a post-peer-review, pre-copyedit version of an article published in European Journal of Nutrition. The final authenticated version is available online at: [http://dx.doi.org/10.1007/s00394-018-1730-1] | |
dc.identifier.doi | 10.1007/s00394-018-1730-1 | |
dc.identifier.pmid | 29845385 | |
dc.identifier.scopus | 2-s2.0-85047661903 | |
dc.identifier.wos | 000476492800007 | |
dc.citation.apa | Veličković, N., Teofilović, A., Ilić, D., Djordjevic, A., Vojnović Milutinović, D., Petrović, S., … Matić, G. (2018). Modulation of hepatic inflammation and energy-sensing pathways in the rat liver by high-fructose diet and chronic stress. European Journal of Nutrition, DOI:10.1007/s00394-018-1730-1. | |
dc.citation.vancouver | Veličković N, Teofilović A, Ilić D, Djordjevic A, Vojnović Milutinović D, Petrović S, Preitner F, Tappy L, Matić G. Modulation of hepatic inflammation and energy-sensing pathways in the rat liver by high-fructose diet and chronic stress. Eur J Nutr. 2018;DOI:10.1007/s00394-018-1730-1. | |
dc.citation.spage | 1 | |
dc.citation.epage | 17 | |
dc.type.version | acceptedVersion | |
dc.identifier.fulltext | https://radar.ibiss.bg.ac.rs/bitstream/id/4321/EurJNutr_2018.pdf | |
dc.citation.rank | M21 |