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Age-related differences in MK-801- and amphetamine-induced locomotor and stereotypic activities of rats
dc.creator | Pešić, Vesna | |
dc.creator | Veskov, Rosica | |
dc.creator | Petković, Branka | |
dc.creator | Rakić, Ljubisav | |
dc.creator | Stojiljković, Mirjana | |
dc.date.accessioned | 2020-07-28T11:14:44Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2003 | |
dc.identifier.issn | 0197-4580 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/abs/pii/S0197458002002324?via%3Dihub | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/3812 | |
dc.description.abstract | Changes in locomotor and stereotypic activities induced by an i.p. injection of either (+)-5-methyl-10,11-dihydro-5H-dibenzo(a,d)-cycloheptan-5,10- imine maleate (dizocilpine or MK-801; 0.3 mg/kg) or D-amphetamine sulfate (AMPH; 1.5 mg/kg) were studied in male Mill Hill hooded rats of different age. The following age groups of animals were considered: 28-30 postnatal day (PND)-old rats (peripubertal), 48-50 PND-old (pubertal), 3-month-old (adults), 12-month-old (middle-aged) and 24-month-old (aged). The motor response was measured by an automated animal activity measuring system. The obtained results showed that: (1) in contrast to AMPH, MK-801 induced more pronounced increases of both locomotor and stereotypic activities in peripubertal and pubertal than in adult and aged rats; (2) AMPH induced the same locomotor and stereotypic activity increase in pubertal, adult and middle-aged rats; (3) both AMPH and MK-801 led to a senescence-related decrease of motor activity. These data suggest that the balance of the glutamatergic and dopaminergic systems changes during aging. Such a change is important in understanding schizophrenia and the motor system decline observed in the later stages of life. | en |
dc.language.iso | en | sr |
dc.publisher | Elsevier Science Inc | sr |
dc.relation | Ministry of Science, Technology and Development of the Republic of Serbia (Contract #1647) | sr |
dc.rights | restrictedAccess | sr |
dc.source | Neurobiology of Aging | sr |
dc.subject | Aging | sr |
dc.subject | Peripuberty | sr |
dc.subject | MK-801 | sr |
dc.subject | Amphetamine | sr |
dc.subject | NMDA receptors | sr |
dc.subject | Dopamine transporter | sr |
dc.subject | Locomotor activity | sr |
dc.subject | Stereotypic activity | sr |
dc.subject | Rat | sr |
dc.title | Age-related differences in MK-801- and amphetamine-induced locomotor and stereotypic activities of rats | en |
dc.type | article | sr |
dc.rights.license | ARR | sr |
dcterms.abstract | Пешић, Весна; Весков, Росица; Петковић, Бранка; Ракић, Љубисав; Стојиљковић, Мирјана; | |
dc.rights.holder | © 2002 Elsevier Science Inc. | sr |
dc.citation.issue | 5 | |
dc.citation.volume | 24 | |
dc.identifier.doi | 10.1016/S0197-4580(02)00232-4 | |
dc.identifier.pmid | 12885579 | |
dc.identifier.scopus | 2-s2.0-0041883788 | |
dc.identifier.wos | 000184632500010 | |
dc.citation.spage | 715 | |
dc.citation.epage | 723 | |
dc.type.version | publishedVersion | sr |
dc.citation.rank | aM21 |