dc.creator | Nikolić-Kokić, Aleksandra | |
dc.creator | Mijušković, Ana | |
dc.creator | Tatalović, Nikola | |
dc.creator | Brkljačić, Jelena | |
dc.creator | Miler, Marko | |
dc.creator | Oreščanin Dušić, Zorana | |
dc.creator | Nikolić, Milan | |
dc.creator | Milošević, Verica | |
dc.creator | Blagojević, Duško | |
dc.creator | Spasić, Mihajlo | |
dc.creator | Miljević, Čedo | |
dc.date.accessioned | 2020-10-02T09:34:47Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1528-7394 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/123456789/3900 | |
dc.description.abstract | The use of atypical antipsychotic drugs (APD) was reported to be associated with adverse effects
on the kidneys. Thus, the aim of this study was to examine whether APD exerted their adverse
effects by interfering with the renal antioxidant defense system. Male 3-mo-old Wistar rats were
treated for 28 d with ziprasidone (ZIP), clozapine (CLO), or sertindole (SER) using a daily dose
recommended for antipsychotic drug therapy. The expression and activities of antioxidant
enzymes superoxide dismutase (SOD) type 1 and type 2, catalase (CAT), glutathione reductase
(GR), and glutathione S-transferases (GSTs) activity were measured in the kidneys. Changes in the
kidneys were also evaluated histologically. Ziprasidone, CLO, and SER reduced renal SOD type 1
and type 2 activities. Decreased CAT activity was observed only in SER-treated rats. An inhibition
in GR activity and increased activity of GST was found only after treatment with CLO. Histological
analysis showed dilatation of proximal tubules in kidneys with all three drugs. In conclusion, data
indicate that redox disturbances may contribute to renal morphologic alterations in proximal
tubules in rats treated with all APD. | en |
dc.language.iso | en | sr |
dc.publisher | Taylor & Francis | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173014/RS// | sr |
dc.rights | restrictedAccess | sr |
dc.source | Journal of Toxicology and Environmental Health, Part A: Current Issues | sr |
dc.subject | ziprasidone | sr |
dc.subject | clozapine | sr |
dc.subject | sertindole | sr |
dc.subject | proximal tubules dilatation | sr |
dc.title | Effects of antipsychotic drug administration on antioxidative defense enzymes in male rat kidney | en |
dc.type | article | sr |
dc.rights.license | ARR | sr |
dcterms.abstract | Миљевић, Чедо; Милошевић, Верица; Спасић, Михајло; Николић, Милан; Милер, Марко; Орешчанин Душић, Зорана; Несторов, Јелена; Благојевић, Душко; Николић Кокић, Aлександра; Мијушковић, Aна; Таталовић, Никола; | |
dc.rights.holder | © 2016 Taylor & Francis. | sr |
dc.citation.issue | 20 | |
dc.citation.volume | 79 | |
dc.description.note | Related to: [https://radar.ibiss.bg.ac.rs/handle/123456789/4042] | |
dc.identifier.doi | 10.1080/15287394.2016.1201706 | |
dc.identifier.pmid | 27644343 | |
dc.identifier.scopus | 2-s2.0-84988527274 | |
dc.identifier.wos | 000384551300003 | |
dc.citation.spage | 905 | |
dc.citation.epage | 911 | |
dc.type.version | publishedVersion | sr |
dc.citation.rank | M21 | |