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Defective immunosuppressive function of Treg cells in visceral adipose tissue in MIF deficient mice
dc.creator | Mićanović, Dragica | |
dc.creator | Koprivica, Ivan | |
dc.creator | Stojanović, Ivana D. | |
dc.creator | Saksida, Tamara | |
dc.date.accessioned | 2020-12-21T15:58:16Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2021 | |
dc.identifier.issn | 1043-4666 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/4052 | |
dc.description.abstract | Obesity, a global health problem nowadays, is a state of low-grade chronic inflammation of adipose tissue (AT) associated with increased adipocyte growth and proliferation and immune cell polarization towards an inflammatory phenotype within the stromal vascular fraction (SVF). Pro-inflammatory cells in the AT produce mediators of inflammation (IL-1β, TNF, macrophage migration inhibitory factor – MIF), thereby surpassing the anti-inflammatory response mediated by IL-10 and TGF-β, cytokines produced by regulatory T (Treg) cells. In this study we demonstrate that the absence of the pro-inflammatory cytokine MIF led to obesity and inflammation in the visceral AT (VAT) in 6 months old MIF- /- mice. Besides the increment of pro-inflammatory AT macrophages and the enhanced production of TNF and IL-1β, VAT of MIF- /- mice contained increased numbers of Treg cells. In situ proliferation of Treg cells did not differ between MIF- /- and wild type mice, but Treg cells isolated from the VAT of MIF-deficient mice, and not from the cervical lymph nodes, exhibited lower expression and production of IL-10 and TGF-β. Additionally, SVF cells had significantly lower levels of STAT3 and IL-33, altogether indicating that VAT Treg cells in MIF- /- mice, albeit abundantly present, are not fully functional. These results indicate that MIF is a new regulator of VAT Treg cell function, necessary for their immunosuppressive activities. | en |
dc.language.iso | en | sr |
dc.publisher | Netherlands: Elsevier | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200007/RS// | sr |
dc.rights | restrictedAccess | sr |
dc.source | Cytokine | sr |
dc.subject | Obesity | sr |
dc.subject | Treg cells | sr |
dc.subject | MIF | sr |
dc.subject | IL-10 | sr |
dc.subject | Visceral adipose tissue | sr |
dc.subject | Immunosuppressive function | sr |
dc.title | Defective immunosuppressive function of Treg cells in visceral adipose tissue in MIF deficient mice | en |
dc.type | article | sr |
dc.rights.license | ARR | sr |
dcterms.abstract | Гајић, Драгица; Саксида, Тамара; Стојановић, Ивана; Копривица, Иван; Дефецтиве иммуносуппрессиве фунцтион оф Трег целлс ин висцерал адипосе тиссуе ин МИФ дефициент мице; Дефецтиве иммуносуппрессиве фунцтион оф Трег целлс ин висцерал адипосе тиссуе ин МИФ дефициент мице; | |
dc.rights.holder | © 2020 Elsevier Ltd. | sr |
dc.citation.volume | 138 | |
dc.identifier.doi | 10.1016/j.cyto.2020.155372 | |
dc.identifier.pmid | 33246771 | |
dc.identifier.scopus | 2-s2.0-85097080879 | |
dc.identifier.wos | 000612690900019 | |
dc.citation.apa | Gajic, D., Koprivica, I., Stojanovic, I., & Saksida, T. (2020). Defective immunosuppressive function of Treg cells in visceral adipose tissue in MIF deficient mice. Cytokine, 155372. | |
dc.citation.vancouver | Gajic D, Koprivica I, Stojanovic I, Saksida T. Defective immunosuppressive function of Treg cells in visceral adipose tissue in MIF deficient mice. Cytokine. 2020;155372. | |
dc.citation.spage | 155372 | |
dc.type.version | publishedVersion | sr |
dc.citation.rank | M22 |