The emerging aspect of antimicrobial concept – exploring the antibiofilm activities of natural products
2021
Autori:
Ivanov, MarijaStojković, Dejan
Kostić, Marina
Petrović, Jovana
Ćirić, Ana
Glamočlija, Jasmina
Soković, Marina
Ostala autorstva
Soković, MarinaKostić, Marina
Tip dokumenta:
Konferencijski prilog (Objavljena verzija)
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© 2021 Institute for Biological Research "Siniša Stanković" – National Institute of Republic of Serbia, University of Belgrade
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
Until some years ago, the antimicrobial activities of different products have been
studied mainly on the planktonic microbial cells. On the other hand, we have now
witnessed that when microorganisms cause infections they do not do it solely but
are able to communicate and group into the structures called the biofilms. Biofilms
are communities of microbial cells packed inside the extracellular matrix composed
mainly of polysaccharides and extracellular DNA. By establishing the biofilm structure,
microorganisms increase their ability to defy antibiotic treatment and though gain
antibiotic resistance. The biofilm structures require few times higher concentrations of
antimicrobial agents in order to get diminished, compared to planktonic cells studied in
the antimicrobial assays. Though, in order to claim that some product has antimicrobial
properties observing its effect on the microorganisms in the biofilms should be a must.
Range of natural products has been studied up to date as antibiofilm agents. Some
of them could act as agents to prevent infections by reducing the microorganism’s
ability to group into the biofilms. Others act on the already established biofilms and
break down their resistant structures. Just some of the natural products studied so far
for their antibiofilm effects are plants Nepeta nuda and Artemisia absinthium, different
polyphenols and terpenes. These agents have displayed wide antibiofilm potential
and though provide the step forward towards the development of efficient antibiofilm
therapeutics.
Finansiranje / projekti:
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200007 (Univerzitet u Beogradu, Institut za biološka istraživanja 'Siniša Stanković') (RS-MESTD-inst-2020-200007)
U:
- Soković M, Kostić M, editors. Book of abstracts: The 3rd Annual Conference of the Pan-Balkan Alliance of Natural Products and Drug Discovery Associations (PANDA); 2021 Nov 1; Belgrade, Serbia. Belgrade : Institute for Biological Research "Siniša Stanković" - National institute of Republic of Serbia (IBISS), University; 2021. p. 14.