TY  - JOUR
AU  - Milić, Ljiljana
AU  - Karamarković, Aleksandar
AU  - Popadić, Dušan
AU  - Šijački, Ana
AU  - Grigorov, Ilijana
AU  - Milošević, Emina
AU  - Ćuk, Vladica
AU  - Pesko, Predrag
PY  - 2019
UR  - https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-019-4310-4
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3362
AB  - Objective

Peptic ulcer disease is a condition in which an important role has infection with H. pylori. The most common complication of peptic ulcer is bleeding. The presence of H. pylori triggers local and systemic cytokine signaling which may affect processes such as healing, gastric or duodenal rupture, and carcinogenesis. In this study, we examined the concentrations of IL-1β, IL-6, IL-10, TNF, TGF-β and IL-17A in serum by enzyme immunoassay and their mRNA expressions in periulcer biopsies obtained from patients with bleeding peptic ulcer by means of real-time-PCR.
Results

We have shown that pro-inflammatory IL-6 and TNF concentrations in serum were significantly higher in patients who were infected with H. pylori, while the concentrations of TGF-β and IL-17A were significantly lower compared to non-infected subjects. IL-17A expression in periulcer mucosa was significantly higher in patients who were infected with H. pylori, while the expression of other cytokines, there was no significant difference compared to non-infected controls. Considering higher serum concentrations in non-infected subjects and higher IL-17A expression in mucosal tissue of infected patients, our data support the studies that found IL-17A has protective role in eradication of H. pylori infection in infected patients.
PB  - BioMed Central Ltd.
T2  - BMC Research Notes
T1  - Altered cytokine expression in Helicobacter pylori infected patients with bleeding duodenal ulcer
VL  - 12
DO  - 10.1186/s13104-019-4310-4
SP  - 278
ER  - 

@article{
author = "Milić, Ljiljana and Karamarković, Aleksandar and Popadić, Dušan and Šijački, Ana and Grigorov, Ilijana and Milošević, Emina and Ćuk, Vladica and Pesko, Predrag",
year = "2019",
abstract = "Objective

Peptic ulcer disease is a condition in which an important role has infection with H. pylori. The most common complication of peptic ulcer is bleeding. The presence of H. pylori triggers local and systemic cytokine signaling which may affect processes such as healing, gastric or duodenal rupture, and carcinogenesis. In this study, we examined the concentrations of IL-1β, IL-6, IL-10, TNF, TGF-β and IL-17A in serum by enzyme immunoassay and their mRNA expressions in periulcer biopsies obtained from patients with bleeding peptic ulcer by means of real-time-PCR.
Results

We have shown that pro-inflammatory IL-6 and TNF concentrations in serum were significantly higher in patients who were infected with H. pylori, while the concentrations of TGF-β and IL-17A were significantly lower compared to non-infected subjects. IL-17A expression in periulcer mucosa was significantly higher in patients who were infected with H. pylori, while the expression of other cytokines, there was no significant difference compared to non-infected controls. Considering higher serum concentrations in non-infected subjects and higher IL-17A expression in mucosal tissue of infected patients, our data support the studies that found IL-17A has protective role in eradication of H. pylori infection in infected patients.",
publisher = "BioMed Central Ltd.",
journal = "BMC Research Notes",
title = "Altered cytokine expression in Helicobacter pylori infected patients with bleeding duodenal ulcer",
volume = "12",
doi = "10.1186/s13104-019-4310-4",
pages = "278"
}

Milić, L., Karamarković, A., Popadić, D., Šijački, A., Grigorov, I., Milošević, E., Ćuk, V.,& Pesko, P.. (2019). Altered cytokine expression in Helicobacter pylori infected patients with bleeding duodenal ulcer. in BMC Research Notes
BioMed Central Ltd.., 12, 278.
https://doi.org/10.1186/s13104-019-4310-4

Milić L, Karamarković A, Popadić D, Šijački A, Grigorov I, Milošević E, Ćuk V, Pesko P. Altered cytokine expression in Helicobacter pylori infected patients with bleeding duodenal ulcer. in BMC Research Notes. 2019;12:278.
doi:10.1186/s13104-019-4310-4 .

Milić, Ljiljana, Karamarković, Aleksandar, Popadić, Dušan, Šijački, Ana, Grigorov, Ilijana, Milošević, Emina, Ćuk, Vladica, Pesko, Predrag, "Altered cytokine expression in Helicobacter pylori infected patients with bleeding duodenal ulcer" in BMC Research Notes, 12 (2019):278,
https://doi.org/10.1186/s13104-019-4310-4 . .

TY  - JOUR
AU  - Mihailović, Mirjana
AU  - Arambašić Jovanović, Jelena
AU  - Uskoković, Aleksandra
AU  - Dinić, Svetlana
AU  - Grdović, Nevena
AU  - Marković, Jelena
AU  - Mujić, Ibrahim
AU  - Šijački, Ana D.
AU  - Poznanović, Goran
AU  - Vidaković, Melita
PY  - 2013
UR  - http://search.crossref.org/?q=10.1016%2Fj.jff.2012.10.016+
UR  - http://linkinghub.elsevier.com/retrieve/pii/S1756464612001624
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3183
AB  - The mechanisms underlying the beneficial effect observed in diabetic rats after treatment with a commercially available β-glucan-enriched extract (BGEE) were examined. Multiple low-dose streptozotocin (STZ) diabetes was used (40 mg STZ/kg) as a model for type 1 diabetes. BGEE was administered daily (80 mg/kg) for 4 weeks, starting from the last day of the STZ treatment. In vitro and in vivo experiments suggest that significant free radical scavenging and antioxidant activities of BGEE were responsible for a systemic adjustment of the redox disturbance and reduction of DNA damage in the liver and kidney of diabetic rats. BGEE-treated diabetic rats also displayed increased Akt kinase activity and decreased pro-caspase-3 degradation, implying that BGEE mediates its beneficial effects through activation of the cellular pro-survival pathway. We conclude that β-glucan administration under diabetic conditions promotes a systemic improvement that can be expected to increase the organism’s resistance to the onset of diabetic complications.
PB  - Elsevier
T2  - Journal of Functional Foods
T1  - β-Glucan administration to diabetic rats reestablishes redox balance and stimulates cellular pro-survival mechanisms
IS  - 1
VL  - 5
DO  - 10.1016/j.jff.2012.10.016
SP  - 267
EP  - 278
ER  - 

@article{
author = "Mihailović, Mirjana and Arambašić Jovanović, Jelena and Uskoković, Aleksandra and Dinić, Svetlana and Grdović, Nevena and Marković, Jelena and Mujić, Ibrahim and Šijački, Ana D. and Poznanović, Goran and Vidaković, Melita",
year = "2013",
abstract = "The mechanisms underlying the beneficial effect observed in diabetic rats after treatment with a commercially available β-glucan-enriched extract (BGEE) were examined. Multiple low-dose streptozotocin (STZ) diabetes was used (40 mg STZ/kg) as a model for type 1 diabetes. BGEE was administered daily (80 mg/kg) for 4 weeks, starting from the last day of the STZ treatment. In vitro and in vivo experiments suggest that significant free radical scavenging and antioxidant activities of BGEE were responsible for a systemic adjustment of the redox disturbance and reduction of DNA damage in the liver and kidney of diabetic rats. BGEE-treated diabetic rats also displayed increased Akt kinase activity and decreased pro-caspase-3 degradation, implying that BGEE mediates its beneficial effects through activation of the cellular pro-survival pathway. We conclude that β-glucan administration under diabetic conditions promotes a systemic improvement that can be expected to increase the organism’s resistance to the onset of diabetic complications.",
publisher = "Elsevier",
journal = "Journal of Functional Foods",
title = "β-Glucan administration to diabetic rats reestablishes redox balance and stimulates cellular pro-survival mechanisms",
number = "1",
volume = "5",
doi = "10.1016/j.jff.2012.10.016",
pages = "267-278"
}

Mihailović, M., Arambašić Jovanović, J., Uskoković, A., Dinić, S., Grdović, N., Marković, J., Mujić, I., Šijački, A. D., Poznanović, G.,& Vidaković, M.. (2013). β-Glucan administration to diabetic rats reestablishes redox balance and stimulates cellular pro-survival mechanisms. in Journal of Functional Foods
Elsevier., 5(1), 267-278.
https://doi.org/10.1016/j.jff.2012.10.016

Mihailović M, Arambašić Jovanović J, Uskoković A, Dinić S, Grdović N, Marković J, Mujić I, Šijački AD, Poznanović G, Vidaković M. β-Glucan administration to diabetic rats reestablishes redox balance and stimulates cellular pro-survival mechanisms. in Journal of Functional Foods. 2013;5(1):267-278.
doi:10.1016/j.jff.2012.10.016 .

Mihailović, Mirjana, Arambašić Jovanović, Jelena, Uskoković, Aleksandra, Dinić, Svetlana, Grdović, Nevena, Marković, Jelena, Mujić, Ibrahim, Šijački, Ana D., Poznanović, Goran, Vidaković, Melita, "β-Glucan administration to diabetic rats reestablishes redox balance and stimulates cellular pro-survival mechanisms" in Journal of Functional Foods, 5, no. 1 (2013):267-278,
https://doi.org/10.1016/j.jff.2012.10.016 . .