TY  - JOUR
AU  - Stojsavljević, Aleksandar
AU  - Jagodić, Jovana
AU  - Pavlović, Slađan
AU  - Dinčić, Evica
AU  - Kuveljić, Jovana
AU  - Manojlović, Dragan
AU  - Živković, Maja
PY  - 2024
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6584
AB  - Background: Multiple sclerosis (MS) is a chronic demyelinating disorder intricately linked to perturbations in
trace element levels. While previous studies have explored circulating trace elements in a limited sample, understanding the impact of demographic and clinical variables on the elemental profile within a larger cohort
remains elusive.
Methods: This study aimed to evaluate essential trace elements (Cr, Mn, Co, Cu, Zn, and Se) in the sera of 215 MS
patients compared to a meticulously matched control group of 100 individuals with similar gender and age. Our
main objective was to identify potential variations in elemental profiles based on demographic and clinical
parameters among MS patients, elucidating the prospective relevance of supplementing specific essential trace
elements.
Results: Data indicated a significant decrease in serum levels of Mn, Co, Zn, and Se, and an increase in Cr in MS
patients compared to controls. These trace elements not only discriminated between MS patients and controls but
also exhibited distinctive capabilities among demographic subgroups. Gender, smoking habits, and age strata
(20–40 years and 41–60 years) revealed discernible variations in elemental profiles between MS patients and
their control counterparts. Se demonstrated the singular ability to stratify cases of extreme MS severity, mild
relapsing-remitting MS (RRMS) and highly severe secondary progressive MS (SPMS). In contrast, Co significantly
differentiated RRMS from primary progressive MS (PPMS), while Cu significantly differentiated SPMS from
PPMS. Additionally, Cu showed a negative correlation with MSSS, while Mn and Zn showed a positive correlation
with EDSS.
Conclusion: These findings underscore a substantive deficiency in Mn, Co, Zn, and Se in the MS cohort, supporting
targeted supplementation with these trace elements. This study provides a comprehensive understanding of the
intricate relationship between essential trace elements and MS, paving the way for further research into
personalized nutritional interventions for this complex neurological disorder.
PB  - Elsevier
T2  - Journal of Trace Elements in Medicine and Biology
T1  - Essential Trace Element Levels in Multiple Sclerosis: Bridging Demographic and Clinical Gaps, Assessing the Need for Supplementation
VL  - 83
DO  - 10.1016/j.jtemb.2024.127421
SP  - 127421
ER  - 

@article{
author = "Stojsavljević, Aleksandar and Jagodić, Jovana and Pavlović, Slađan and Dinčić, Evica and Kuveljić, Jovana and Manojlović, Dragan and Živković, Maja",
year = "2024",
abstract = "Background: Multiple sclerosis (MS) is a chronic demyelinating disorder intricately linked to perturbations in
trace element levels. While previous studies have explored circulating trace elements in a limited sample, understanding the impact of demographic and clinical variables on the elemental profile within a larger cohort
remains elusive.
Methods: This study aimed to evaluate essential trace elements (Cr, Mn, Co, Cu, Zn, and Se) in the sera of 215 MS
patients compared to a meticulously matched control group of 100 individuals with similar gender and age. Our
main objective was to identify potential variations in elemental profiles based on demographic and clinical
parameters among MS patients, elucidating the prospective relevance of supplementing specific essential trace
elements.
Results: Data indicated a significant decrease in serum levels of Mn, Co, Zn, and Se, and an increase in Cr in MS
patients compared to controls. These trace elements not only discriminated between MS patients and controls but
also exhibited distinctive capabilities among demographic subgroups. Gender, smoking habits, and age strata
(20–40 years and 41–60 years) revealed discernible variations in elemental profiles between MS patients and
their control counterparts. Se demonstrated the singular ability to stratify cases of extreme MS severity, mild
relapsing-remitting MS (RRMS) and highly severe secondary progressive MS (SPMS). In contrast, Co significantly
differentiated RRMS from primary progressive MS (PPMS), while Cu significantly differentiated SPMS from
PPMS. Additionally, Cu showed a negative correlation with MSSS, while Mn and Zn showed a positive correlation
with EDSS.
Conclusion: These findings underscore a substantive deficiency in Mn, Co, Zn, and Se in the MS cohort, supporting
targeted supplementation with these trace elements. This study provides a comprehensive understanding of the
intricate relationship between essential trace elements and MS, paving the way for further research into
personalized nutritional interventions for this complex neurological disorder.",
publisher = "Elsevier",
journal = "Journal of Trace Elements in Medicine and Biology",
title = "Essential Trace Element Levels in Multiple Sclerosis: Bridging Demographic and Clinical Gaps, Assessing the Need for Supplementation",
volume = "83",
doi = "10.1016/j.jtemb.2024.127421",
pages = "127421"
}

Stojsavljević, A., Jagodić, J., Pavlović, S., Dinčić, E., Kuveljić, J., Manojlović, D.,& Živković, M.. (2024). Essential Trace Element Levels in Multiple Sclerosis: Bridging Demographic and Clinical Gaps, Assessing the Need for Supplementation. in Journal of Trace Elements in Medicine and Biology
Elsevier., 83, 127421.
https://doi.org/10.1016/j.jtemb.2024.127421

Stojsavljević A, Jagodić J, Pavlović S, Dinčić E, Kuveljić J, Manojlović D, Živković M. Essential Trace Element Levels in Multiple Sclerosis: Bridging Demographic and Clinical Gaps, Assessing the Need for Supplementation. in Journal of Trace Elements in Medicine and Biology. 2024;83:127421.
doi:10.1016/j.jtemb.2024.127421 .

Stojsavljević, Aleksandar, Jagodić, Jovana, Pavlović, Slađan, Dinčić, Evica, Kuveljić, Jovana, Manojlović, Dragan, Živković, Maja, "Essential Trace Element Levels in Multiple Sclerosis: Bridging Demographic and Clinical Gaps, Assessing the Need for Supplementation" in Journal of Trace Elements in Medicine and Biology, 83 (2024):127421,
https://doi.org/10.1016/j.jtemb.2024.127421 . .

TY  - JOUR
AU  - Jagodić, Jovana
AU  - Pavlović, Slađan
AU  - Borković Mitić, Slavica
AU  - Perović, Milan
AU  - Miković, Željko
AU  - Đurđić, Slađana
AU  - Manojlović, Dragan
AU  - Stojsavljević, Aleksandar
PY  - 2022
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5020
AB  - With the ever-growing concern for human health and wellbeing, the prenatal period of
development requires special attention since fetuses can be exposed to various metals through the
mother. Therefore, this study explored the status of selected toxic (Pb, Cd, Ni, As, Pt, Ce, Rb, Sr, U)
and essential trace metals (Mn, Co, Cu, Zn, Se) in the umbilical cord (UC) sera, maternal sera, and
placental tissue samples of 92 healthy women with normal pregnancies. A further aim focuses on the
potential transplacental transfer of these trace metals. Based on the obtained levels of investigated
elements in clinical samples, it was observed that all of the trace metals cross the placental barrier
and reach the fetus. Furthermore, statistical analysis revealed significant differences in levels of
toxic Ni, As, Cd, U, Sr, Rb, and essential Mn, Cu, and Zn between all three types of analyzed clinical
samples. Correlation analysis highlighted As to be an element with levels that differed significantly
between all tested samples. Principal component analysis (PCA) was used to enhance these findings.
PCA demonstrated that Cd, Mn, Zn, Rb, Ce, U, and Sr were the most influential trace metals in
distinguishing placenta from maternal and UC serum samples. As, Co, and Cu were responsible for
the clustering of maternal serum samples, and PCA demonstrated that the Pt level in UC sera was
responsible for the clustering of these samples. Overall, the findings of this study could contribute to
a better understanding of transplacental transfer of these trace metals, and shed a light on overall
levels of metal exposure in the population of healthy pregnant women and their fetuses.
PB  - Basel: MDPI
T2  - International Journal of Molecular Sciences
T1  - Examination of Trace Metals and Their Potential Transplacental Transfer in Pregnancy
IS  - 15
VL  - 23
DO  - 10.3390/ijms23158078
SP  - 8078
ER  - 

@article{
author = "Jagodić, Jovana and Pavlović, Slađan and Borković Mitić, Slavica and Perović, Milan and Miković, Željko and Đurđić, Slađana and Manojlović, Dragan and Stojsavljević, Aleksandar",
year = "2022",
abstract = "With the ever-growing concern for human health and wellbeing, the prenatal period of
development requires special attention since fetuses can be exposed to various metals through the
mother. Therefore, this study explored the status of selected toxic (Pb, Cd, Ni, As, Pt, Ce, Rb, Sr, U)
and essential trace metals (Mn, Co, Cu, Zn, Se) in the umbilical cord (UC) sera, maternal sera, and
placental tissue samples of 92 healthy women with normal pregnancies. A further aim focuses on the
potential transplacental transfer of these trace metals. Based on the obtained levels of investigated
elements in clinical samples, it was observed that all of the trace metals cross the placental barrier
and reach the fetus. Furthermore, statistical analysis revealed significant differences in levels of
toxic Ni, As, Cd, U, Sr, Rb, and essential Mn, Cu, and Zn between all three types of analyzed clinical
samples. Correlation analysis highlighted As to be an element with levels that differed significantly
between all tested samples. Principal component analysis (PCA) was used to enhance these findings.
PCA demonstrated that Cd, Mn, Zn, Rb, Ce, U, and Sr were the most influential trace metals in
distinguishing placenta from maternal and UC serum samples. As, Co, and Cu were responsible for
the clustering of maternal serum samples, and PCA demonstrated that the Pt level in UC sera was
responsible for the clustering of these samples. Overall, the findings of this study could contribute to
a better understanding of transplacental transfer of these trace metals, and shed a light on overall
levels of metal exposure in the population of healthy pregnant women and their fetuses.",
publisher = "Basel: MDPI",
journal = "International Journal of Molecular Sciences",
title = "Examination of Trace Metals and Their Potential Transplacental Transfer in Pregnancy",
number = "15",
volume = "23",
doi = "10.3390/ijms23158078",
pages = "8078"
}

Jagodić, J., Pavlović, S., Borković Mitić, S., Perović, M., Miković, Ž., Đurđić, S., Manojlović, D.,& Stojsavljević, A.. (2022). Examination of Trace Metals and Their Potential Transplacental Transfer in Pregnancy. in International Journal of Molecular Sciences
Basel: MDPI., 23(15), 8078.
https://doi.org/10.3390/ijms23158078

Jagodić J, Pavlović S, Borković Mitić S, Perović M, Miković Ž, Đurđić S, Manojlović D, Stojsavljević A. Examination of Trace Metals and Their Potential Transplacental Transfer in Pregnancy. in International Journal of Molecular Sciences. 2022;23(15):8078.
doi:10.3390/ijms23158078 .

Jagodić, Jovana, Pavlović, Slađan, Borković Mitić, Slavica, Perović, Milan, Miković, Željko, Đurđić, Slađana, Manojlović, Dragan, Stojsavljević, Aleksandar, "Examination of Trace Metals and Their Potential Transplacental Transfer in Pregnancy" in International Journal of Molecular Sciences, 23, no. 15 (2022):8078,
https://doi.org/10.3390/ijms23158078 . .

TY  - JOUR
AU  - Jagodić, Jovana
AU  - Rovčanin, Branislav
AU  - Borković Mitić, Slavica
AU  - Vujotić, Ljiljana
AU  - Avdin, Viacheslav
AU  - Manojlović, Dragan
AU  - Stojsavljević, Aleksandar
PY  - 2021
UR  - https://doi.org/10.1007/s11356-021-14013-2
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4236
AB  - Studies indicate that the soil, water and consequently foodstuffs in Serbia are significantly poor in zinc (Zn), and thus, it is likely that there is a Zn deficiency in the Serbian population. This study examined the Zn status in multiple clinical samples, including body fluids (serum, cerebrospinal fluid), whole blood and Zn-rich solid tissues (thyroid and brain tissue). Differences between sex and age were also considered, and comparative analysis of Zn status with other world populations was performed. Serum samples from a large number of Serbian adults approximately had twofold lower Zn amounts when compared to other populations. A similar trend was obtained for whole blood. Males had significantly higher amounts of Zn in serum, whole blood and thyroid tissue samples than females. Higher amounts of Zn were observed in the group older than 50 years. Importantly, in thyroid and brain tissues, Zn was 10- and 20-fold lower, respectively, than reported in the literature. Our results indicate that the population in Serbia could be considered Zn deficient. Therefore, adequate oral Zn supplementation and/or foodstuff fortification should be considered to prevent the deleterious effects caused by Zn deficiency.
PB  - Springer Science and Business Media Deutschland GmbH
T2  - Environmental Science and Pollution Research
T1  - Possible zinc deficiency in the Serbian population: examination of body fluids, whole blood and solid tissues
IS  - 34
VL  - 28
DO  - 10.1007/s11356-021-14013-2
SP  - 47439
EP  - 47446
ER  - 

@article{
author = "Jagodić, Jovana and Rovčanin, Branislav and Borković Mitić, Slavica and Vujotić, Ljiljana and Avdin, Viacheslav and Manojlović, Dragan and Stojsavljević, Aleksandar",
year = "2021",
abstract = "Studies indicate that the soil, water and consequently foodstuffs in Serbia are significantly poor in zinc (Zn), and thus, it is likely that there is a Zn deficiency in the Serbian population. This study examined the Zn status in multiple clinical samples, including body fluids (serum, cerebrospinal fluid), whole blood and Zn-rich solid tissues (thyroid and brain tissue). Differences between sex and age were also considered, and comparative analysis of Zn status with other world populations was performed. Serum samples from a large number of Serbian adults approximately had twofold lower Zn amounts when compared to other populations. A similar trend was obtained for whole blood. Males had significantly higher amounts of Zn in serum, whole blood and thyroid tissue samples than females. Higher amounts of Zn were observed in the group older than 50 years. Importantly, in thyroid and brain tissues, Zn was 10- and 20-fold lower, respectively, than reported in the literature. Our results indicate that the population in Serbia could be considered Zn deficient. Therefore, adequate oral Zn supplementation and/or foodstuff fortification should be considered to prevent the deleterious effects caused by Zn deficiency.",
publisher = "Springer Science and Business Media Deutschland GmbH",
journal = "Environmental Science and Pollution Research",
title = "Possible zinc deficiency in the Serbian population: examination of body fluids, whole blood and solid tissues",
number = "34",
volume = "28",
doi = "10.1007/s11356-021-14013-2",
pages = "47439-47446"
}

Jagodić, J., Rovčanin, B., Borković Mitić, S., Vujotić, L., Avdin, V., Manojlović, D.,& Stojsavljević, A.. (2021). Possible zinc deficiency in the Serbian population: examination of body fluids, whole blood and solid tissues. in Environmental Science and Pollution Research
Springer Science and Business Media Deutschland GmbH., 28(34), 47439-47446.
https://doi.org/10.1007/s11356-021-14013-2

Jagodić J, Rovčanin B, Borković Mitić S, Vujotić L, Avdin V, Manojlović D, Stojsavljević A. Possible zinc deficiency in the Serbian population: examination of body fluids, whole blood and solid tissues. in Environmental Science and Pollution Research. 2021;28(34):47439-47446.
doi:10.1007/s11356-021-14013-2 .

Jagodić, Jovana, Rovčanin, Branislav, Borković Mitić, Slavica, Vujotić, Ljiljana, Avdin, Viacheslav, Manojlović, Dragan, Stojsavljević, Aleksandar, "Possible zinc deficiency in the Serbian population: examination of body fluids, whole blood and solid tissues" in Environmental Science and Pollution Research, 28, no. 34 (2021):47439-47446,
https://doi.org/10.1007/s11356-021-14013-2 . .

TY  - JOUR
AU  - Stojsavljević, Aleksandar
AU  - Jagodić, Jovana
AU  - Vujotić, Ljiljana
AU  - Borković Mitić, Slavica
AU  - Rašić-Milutinović, Zorica
AU  - Jovanović, Dragana
AU  - Gavrović-Jankulović, Marija
AU  - Manojlović, Dragan
PY  - 2020
UR  - http://link.springer.com/10.1007/s11356-019-06936-8
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3530
AB  - This study was aimed to determine reference values (RVs) for the manganese (Mn), copper (Cu), zinc (Zn), and selenium (Se) in the whole blood (B) and serum (S) samples of the Serbian population. Blood specimens were collected from healthy persons (n = 295; women/men ratio = 149/146; mean age: 42 ± 2 years). The RVs were calculated as lower limit (LL) and upper limit (UL) of the 95% confidence interval (CI) and were expressed as percentiles (P) in the range from P2.5 to P97.5. The influences of sex, age, and smoking habits on element profiles were considered. It was found that the contents of B-Cu and S-Cu were higher in women, while the contents of B-Zn and S-Zn were higher in men. Both trace elements were significantly increased in a group of persons above 40 when compared to a younger persons (≤ 40 years). According to smoking habits, increased content was found only for S-Mn in the nonsmoker's group (p < 0.05). Comparing our results to the results reported in other population groups worldwide, the Serbian population had significantly reduced content of Se in both types of samples. This finding could highlight the deficiency of Se in the investigated Serbian population and could contribute to the better understanding of the molecular basis for the increased incidence of thyroid and other diseases in which selenium plays a key role.
T2  - Environmental Science and Pollution Research
T1  - Reference values for trace essential elements in the whole blood and serum samples of the adult Serbian population: significance of selenium deficiency.
IS  - 2
VL  - 27
DO  - 10.1007/s11356-019-06936-8
SP  - 1397
EP  - 1405
ER  - 

@article{
author = "Stojsavljević, Aleksandar and Jagodić, Jovana and Vujotić, Ljiljana and Borković Mitić, Slavica and Rašić-Milutinović, Zorica and Jovanović, Dragana and Gavrović-Jankulović, Marija and Manojlović, Dragan",
year = "2020",
abstract = "This study was aimed to determine reference values (RVs) for the manganese (Mn), copper (Cu), zinc (Zn), and selenium (Se) in the whole blood (B) and serum (S) samples of the Serbian population. Blood specimens were collected from healthy persons (n = 295; women/men ratio = 149/146; mean age: 42 ± 2 years). The RVs were calculated as lower limit (LL) and upper limit (UL) of the 95% confidence interval (CI) and were expressed as percentiles (P) in the range from P2.5 to P97.5. The influences of sex, age, and smoking habits on element profiles were considered. It was found that the contents of B-Cu and S-Cu were higher in women, while the contents of B-Zn and S-Zn were higher in men. Both trace elements were significantly increased in a group of persons above 40 when compared to a younger persons (≤ 40 years). According to smoking habits, increased content was found only for S-Mn in the nonsmoker's group (p < 0.05). Comparing our results to the results reported in other population groups worldwide, the Serbian population had significantly reduced content of Se in both types of samples. This finding could highlight the deficiency of Se in the investigated Serbian population and could contribute to the better understanding of the molecular basis for the increased incidence of thyroid and other diseases in which selenium plays a key role.",
journal = "Environmental Science and Pollution Research",
title = "Reference values for trace essential elements in the whole blood and serum samples of the adult Serbian population: significance of selenium deficiency.",
number = "2",
volume = "27",
doi = "10.1007/s11356-019-06936-8",
pages = "1397-1405"
}

Stojsavljević, A., Jagodić, J., Vujotić, L., Borković Mitić, S., Rašić-Milutinović, Z., Jovanović, D., Gavrović-Jankulović, M.,& Manojlović, D.. (2020). Reference values for trace essential elements in the whole blood and serum samples of the adult Serbian population: significance of selenium deficiency.. in Environmental Science and Pollution Research, 27(2), 1397-1405.
https://doi.org/10.1007/s11356-019-06936-8

Stojsavljević A, Jagodić J, Vujotić L, Borković Mitić S, Rašić-Milutinović Z, Jovanović D, Gavrović-Jankulović M, Manojlović D. Reference values for trace essential elements in the whole blood and serum samples of the adult Serbian population: significance of selenium deficiency.. in Environmental Science and Pollution Research. 2020;27(2):1397-1405.
doi:10.1007/s11356-019-06936-8 .

Stojsavljević, Aleksandar, Jagodić, Jovana, Vujotić, Ljiljana, Borković Mitić, Slavica, Rašić-Milutinović, Zorica, Jovanović, Dragana, Gavrović-Jankulović, Marija, Manojlović, Dragan, "Reference values for trace essential elements in the whole blood and serum samples of the adult Serbian population: significance of selenium deficiency." in Environmental Science and Pollution Research, 27, no. 2 (2020):1397-1405,
https://doi.org/10.1007/s11356-019-06936-8 . .

TY  - JOUR
AU  - Stojsavljević, Aleksandar
AU  - Rovčanin, Branislav
AU  - Krstić, Đurđa
AU  - Jagodić, Jovana
AU  - Borković Mitić, Slavica
AU  - Paunović, Ivan
AU  - Živaljević, Vladan
AU  - Mitić, Bojan
AU  - Gavrović-Jankulović, Marija
AU  - Manojlović, Dragan
PY  - 2019
UR  - https://www.sciencedirect.com/science/article/pii/S0946672X19300070?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3435
AB  - BACKGROUND The etiology of papillary thyroid carcinoma (PTC) is unknown and some literature data support the hypothesis that heavy metals, as endocrine disrupters, could play a major role in the pathogenesis of thyroid cancer. This study aimed to estimate the content of selected toxic and essential trace metals (Mn, Co, Ni, Cu, Zn, As, Se, Cd, Pb, Th, and U), as well as the selected ratio’s (Cu/Zn and Cd/Se) in the malignant thyroid tissues according to sex, age, smoking habits, familial history of any thyroid disease, pathohistological (PH) types of PTC, tumor size, the existence of a thyroid capsular invasion, intrathyroid tumor dissemination, retrosternal thyroid growth, and TNM progress of PTC. METHODS The study included 66 patients with PTC (women/men ratio = 46/20, mean age: 54 ± 14 years). A comparative analysis was made by collecting the healthy thyroid tissues (HTTs) of the same patients, making the total number of samples 132. All trace metals were quantified by inductively coupled plasma-mass spectrometry (ICP-MS). RESULTS Metals that significantly separated papillary thyroid tissues (PTTs) from the HTTs were Cd, U and Se (p < 0.05). The obtained negative correlation between Cd and Se in the PTTs could explain extrusion of essential Se caused by increased content of Cd. Only Cd had an influence on the retrosternal thyroid growth, while the essential metals (Mn, Co, and Zn) had an influence on thyroid capsular invasion. CONCLUSION It was found that Cd act as the main endocrine disrupter, which could highlight its role in the etiology of PTC. Considering that the Cd/Se ratio significantly separated two studied groups and had an influence on the retrosternal thyroid growth, its altered content could contribute to the better understanding of the molecular basis for pathophysiological changes in the PTC.
T2  - Journal of Trace Elements in Medicine and Biology
T1  - Cadmium as main endocrine disruptor in papillary thyroid carcinoma and the significance of Cd/Se ratio for thyroid tissue pathophysiology
VL  - 55
DO  - 10.1016/J.JTEMB.2019.06.009
SP  - 190
EP  - 195
ER  - 

@article{
author = "Stojsavljević, Aleksandar and Rovčanin, Branislav and Krstić, Đurđa and Jagodić, Jovana and Borković Mitić, Slavica and Paunović, Ivan and Živaljević, Vladan and Mitić, Bojan and Gavrović-Jankulović, Marija and Manojlović, Dragan",
year = "2019",
abstract = "BACKGROUND The etiology of papillary thyroid carcinoma (PTC) is unknown and some literature data support the hypothesis that heavy metals, as endocrine disrupters, could play a major role in the pathogenesis of thyroid cancer. This study aimed to estimate the content of selected toxic and essential trace metals (Mn, Co, Ni, Cu, Zn, As, Se, Cd, Pb, Th, and U), as well as the selected ratio’s (Cu/Zn and Cd/Se) in the malignant thyroid tissues according to sex, age, smoking habits, familial history of any thyroid disease, pathohistological (PH) types of PTC, tumor size, the existence of a thyroid capsular invasion, intrathyroid tumor dissemination, retrosternal thyroid growth, and TNM progress of PTC. METHODS The study included 66 patients with PTC (women/men ratio = 46/20, mean age: 54 ± 14 years). A comparative analysis was made by collecting the healthy thyroid tissues (HTTs) of the same patients, making the total number of samples 132. All trace metals were quantified by inductively coupled plasma-mass spectrometry (ICP-MS). RESULTS Metals that significantly separated papillary thyroid tissues (PTTs) from the HTTs were Cd, U and Se (p < 0.05). The obtained negative correlation between Cd and Se in the PTTs could explain extrusion of essential Se caused by increased content of Cd. Only Cd had an influence on the retrosternal thyroid growth, while the essential metals (Mn, Co, and Zn) had an influence on thyroid capsular invasion. CONCLUSION It was found that Cd act as the main endocrine disrupter, which could highlight its role in the etiology of PTC. Considering that the Cd/Se ratio significantly separated two studied groups and had an influence on the retrosternal thyroid growth, its altered content could contribute to the better understanding of the molecular basis for pathophysiological changes in the PTC.",
journal = "Journal of Trace Elements in Medicine and Biology",
title = "Cadmium as main endocrine disruptor in papillary thyroid carcinoma and the significance of Cd/Se ratio for thyroid tissue pathophysiology",
volume = "55",
doi = "10.1016/J.JTEMB.2019.06.009",
pages = "190-195"
}

Stojsavljević, A., Rovčanin, B., Krstić, Đ., Jagodić, J., Borković Mitić, S., Paunović, I., Živaljević, V., Mitić, B., Gavrović-Jankulović, M.,& Manojlović, D.. (2019). Cadmium as main endocrine disruptor in papillary thyroid carcinoma and the significance of Cd/Se ratio for thyroid tissue pathophysiology. in Journal of Trace Elements in Medicine and Biology, 55, 190-195.
https://doi.org/10.1016/J.JTEMB.2019.06.009

Stojsavljević A, Rovčanin B, Krstić Đ, Jagodić J, Borković Mitić S, Paunović I, Živaljević V, Mitić B, Gavrović-Jankulović M, Manojlović D. Cadmium as main endocrine disruptor in papillary thyroid carcinoma and the significance of Cd/Se ratio for thyroid tissue pathophysiology. in Journal of Trace Elements in Medicine and Biology. 2019;55:190-195.
doi:10.1016/J.JTEMB.2019.06.009 .

Stojsavljević, Aleksandar, Rovčanin, Branislav, Krstić, Đurđa, Jagodić, Jovana, Borković Mitić, Slavica, Paunović, Ivan, Živaljević, Vladan, Mitić, Bojan, Gavrović-Jankulović, Marija, Manojlović, Dragan, "Cadmium as main endocrine disruptor in papillary thyroid carcinoma and the significance of Cd/Se ratio for thyroid tissue pathophysiology" in Journal of Trace Elements in Medicine and Biology, 55 (2019):190-195,
https://doi.org/10.1016/J.JTEMB.2019.06.009 . .