@article{
author = "Stefanovic, Ivan S. and Djonlagic, Jasna and Tovilović-Kovačević, Gordana and Brkljačić, Jelena and Antic, Vesna V. and Ostojic, Sanja and Pergal, Marija V.",
year = "2015",
abstract = "Polyurethane copolymers based on ,-dihydroxypropyl
poly(dimethylsiloxane) (PDMS) with a range of soft segment contents were
prepared by two-stage polymerization, and their microstructures,
thermal, thermomechanical, and surface properties, as well as in vitro
hemo- and cytocompatibility were evaluated. All utilized
characterization methods confirmed the existence of moderately
microphase separated structures with the appearance of some microphase
mixing between segments as the PDMS (i.e., soft segment) content
increased. Copolymers showed higher crystallinity, storage moduli,
surface roughness, and surface free energy, but less hydrophobicity with
decreasing PDMS content. Biocompatibility of copolymers was evaluated
using an endothelial EA.hy926 cell line by direct contact, an extraction
method and after pretreatment of copolymers with multicomponent protein
mixture, as well as by a competitive protein adsorption assay.
Copolymers showed no toxic effect to endothelial cells and all
copolymers, except that with the lowest PDMS content, exhibited
resistance to endothelial cell adhesion, suggesting their unsuitability
for long-term biomedical devices which particularly require
re-endothelialization. All copolymers exhibited excellent resistance to
fibrinogen adsorption and adsorbed more albumin than fibrinogen in the
competitive adsorption assay, suggesting their good hemocompatibility.
The noncytotoxic chemistry of these synthesized materials, combined with
their nonadherent properties which are inhospitable to cell attachment
and growth, underlie the need for further investigations to clarify
their potential for use in short-term biomedical devices. (c) 2014 Wiley
Periodicals, Inc. J Biomed Mater Res Part A: 103A: 1459-1475, 2015.",
journal = "Journal of Biomedical Materials Research Part A",
title = "Poly(urethane-dimethylsiloxane) copolymers displaying a range of soft
segment contents, noncytotoxic chemistry, and nonadherent properties
toward endothelial cells",
number = "4",
volume = "103",
doi = "10.1002/jbm.a.35285",
pages = "1459-1475"
}