TY  - JOUR
AU  - Šošić-Jurjević, Branka 
AU  - Ajdžanović, Vladimir
AU  - Filipović, Branko
AU  - Severs, Walter
AU  - Milošević, Verica
PY  - 2019
UR  - https://www.frontiersin.org/article/10.3389/fendo.2019.00688/full
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3485
AB  - In this opinion article, we intend to elaborate on thyroid mediation of isoflavone effects mainly on the bone of aging males, which appears to have an important role but is still insufficiently analyzed in the existing literature. Namely, the consequences of exposure to endocrine-disrupting chemicals strongly depend on the timing of interaction and life stages of humans and animals, so we intended to highlight the thyroid-related mechanism underlying the beneficial effect of isoflavones on aged male bone.
T2  - Frontiers in Endocrinology
T1  - Thyroid Mediation of the Isoflavone Effects on Osteoporotic Bone: The Endocrine Interference With a Beneficial Outcome
VL  - 10
DO  - 10.3389/fendo.2019.00688
SP  - 688
ER  - 

@article{
author = "Šošić-Jurjević, Branka  and Ajdžanović, Vladimir and Filipović, Branko and Severs, Walter and Milošević, Verica",
year = "2019",
abstract = "In this opinion article, we intend to elaborate on thyroid mediation of isoflavone effects mainly on the bone of aging males, which appears to have an important role but is still insufficiently analyzed in the existing literature. Namely, the consequences of exposure to endocrine-disrupting chemicals strongly depend on the timing of interaction and life stages of humans and animals, so we intended to highlight the thyroid-related mechanism underlying the beneficial effect of isoflavones on aged male bone.",
journal = "Frontiers in Endocrinology",
title = "Thyroid Mediation of the Isoflavone Effects on Osteoporotic Bone: The Endocrine Interference With a Beneficial Outcome",
volume = "10",
doi = "10.3389/fendo.2019.00688",
pages = "688"
}

Šošić-Jurjević, B., Ajdžanović, V., Filipović, B., Severs, W.,& Milošević, V.. (2019). Thyroid Mediation of the Isoflavone Effects on Osteoporotic Bone: The Endocrine Interference With a Beneficial Outcome. in Frontiers in Endocrinology, 10, 688.
https://doi.org/10.3389/fendo.2019.00688

Šošić-Jurjević B, Ajdžanović V, Filipović B, Severs W, Milošević V. Thyroid Mediation of the Isoflavone Effects on Osteoporotic Bone: The Endocrine Interference With a Beneficial Outcome. in Frontiers in Endocrinology. 2019;10:688.
doi:10.3389/fendo.2019.00688 .

Šošić-Jurjević, Branka , Ajdžanović, Vladimir, Filipović, Branko, Severs, Walter, Milošević, Verica, "Thyroid Mediation of the Isoflavone Effects on Osteoporotic Bone: The Endocrine Interference With a Beneficial Outcome" in Frontiers in Endocrinology, 10 (2019):688,
https://doi.org/10.3389/fendo.2019.00688 . .

TY  - JOUR
AU  - Ristić, Nataša
AU  - Severs, Walter
AU  - Nestorović, Nataša
AU  - Jarić, Ivana
AU  - Manojlović-Stojanoski, Milica
AU  - Trifunović, Svetlana
AU  - Pendovski, Lazo
AU  - Milošević, Verica
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2024
AB  - Glucocorticoids have a strong influence on growth and maturation of
   fetal organ systems, but overexposure to exogenous glucocorticoids may
   retard fetal growth and alter developmental processes in sensitive
   tissues. The aim of this study was to specifically determine whether
   prenatal exposure to dexamethasone (Dx) altered normal development and
   function of pituitary gonadotropic cells in neonatal, infant and
   peripubertal female offspring. On day 16 of pregnancy, rat dams received
   1.0 mg Dx/kg body weight (BW) s.c., followed by 0.5 mg Dx/kg BW on days
   17 and 18 of gestation. Control gravid females received the same volume
   of saline. Female offspring were sacrificed on days 5, 16 and 38 after
   delivery. The volume of the pituitary gland estimated using Cavalieri's
   principle was significantly reduced (p < 0.05). Using a
   fractionator-physical disector method, we found reduced total numbers of
   follicle-stimulating hormone (FSH) and luteinizing hormone (LH) cells (p
   < 0.05), accompanied by a decrease (p < 0.05) in serum concentrations of
   FSH and LH, while the relative intensity of FSH and LH
   immunofluorescence remained unchanged in neonatal, infant and
   peripubertal female offspring prenatally exposed to Dx. The data
   document that overexposure to Dx during fetal development evokes
   developmental programming of the female reproductive system at the
   pituitary cellular level, which may be associated with impaired
   reproductive function. (C) 2016 S. Karger AG, Basel
T2  - Cells Tissues Organs
T1  - Effects of Prenatal Dexamethasone on the Rat Pituitary Gland and
 Gonadotropic Cells in Female Offspring
IS  - 2
VL  - 201
DO  - 10.1159/000443987
SP  - 148
EP  - 158
ER  - 

@article{
author = "Ristić, Nataša and Severs, Walter and Nestorović, Nataša and Jarić, Ivana and Manojlović-Stojanoski, Milica and Trifunović, Svetlana and Pendovski, Lazo and Milošević, Verica",
year = "2015",
abstract = "Glucocorticoids have a strong influence on growth and maturation of
   fetal organ systems, but overexposure to exogenous glucocorticoids may
   retard fetal growth and alter developmental processes in sensitive
   tissues. The aim of this study was to specifically determine whether
   prenatal exposure to dexamethasone (Dx) altered normal development and
   function of pituitary gonadotropic cells in neonatal, infant and
   peripubertal female offspring. On day 16 of pregnancy, rat dams received
   1.0 mg Dx/kg body weight (BW) s.c., followed by 0.5 mg Dx/kg BW on days
   17 and 18 of gestation. Control gravid females received the same volume
   of saline. Female offspring were sacrificed on days 5, 16 and 38 after
   delivery. The volume of the pituitary gland estimated using Cavalieri's
   principle was significantly reduced (p < 0.05). Using a
   fractionator-physical disector method, we found reduced total numbers of
   follicle-stimulating hormone (FSH) and luteinizing hormone (LH) cells (p
   < 0.05), accompanied by a decrease (p < 0.05) in serum concentrations of
   FSH and LH, while the relative intensity of FSH and LH
   immunofluorescence remained unchanged in neonatal, infant and
   peripubertal female offspring prenatally exposed to Dx. The data
   document that overexposure to Dx during fetal development evokes
   developmental programming of the female reproductive system at the
   pituitary cellular level, which may be associated with impaired
   reproductive function. (C) 2016 S. Karger AG, Basel",
journal = "Cells Tissues Organs",
title = "Effects of Prenatal Dexamethasone on the Rat Pituitary Gland and
 Gonadotropic Cells in Female Offspring",
number = "2",
volume = "201",
doi = "10.1159/000443987",
pages = "148-158"
}

Ristić, N., Severs, W., Nestorović, N., Jarić, I., Manojlović-Stojanoski, M., Trifunović, S., Pendovski, L.,& Milošević, V.. (2015). Effects of Prenatal Dexamethasone on the Rat Pituitary Gland and
 Gonadotropic Cells in Female Offspring. in Cells Tissues Organs, 201(2), 148-158.
https://doi.org/10.1159/000443987

Ristić N, Severs W, Nestorović N, Jarić I, Manojlović-Stojanoski M, Trifunović S, Pendovski L, Milošević V. Effects of Prenatal Dexamethasone on the Rat Pituitary Gland and
 Gonadotropic Cells in Female Offspring. in Cells Tissues Organs. 2015;201(2):148-158.
doi:10.1159/000443987 .

Ristić, Nataša, Severs, Walter, Nestorović, Nataša, Jarić, Ivana, Manojlović-Stojanoski, Milica, Trifunović, Svetlana, Pendovski, Lazo, Milošević, Verica, "Effects of Prenatal Dexamethasone on the Rat Pituitary Gland and
 Gonadotropic Cells in Female Offspring" in Cells Tissues Organs, 201, no. 2 (2015):148-158,
https://doi.org/10.1159/000443987 . .

TY  - JOUR
AU  - Ajdžanović, Vladimir
AU  - Spasojević, Ivan
AU  - Živanović, Jasmina
AU  - Šošić-Jurjević, Branka 
AU  - Filipović, Branko
AU  - Milošević, Verica
AU  - Severs, Walter
PY  - 2012
PY  - 2012
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/498
AB  - Erythrocyte membrane fluidity is related to their rheologic behavior, the dynamic quality of erythrocytes, which is tempted in hypertension and atherosclerosis. An increased risk of these and other cardiovascular diseases occurs in ageing women. Menopause-related conditions are often treated with hormone replacement therapy that may increase the risk of malignancies. Vitex agnus-castus L. essential oil contains various organic compounds (monoterpenes, sesquiterpenes and terpenoids), and is increasingly used as an alternative therapy for menopausal symptoms. These components of the oil may be incorporated into cell membranes, thereby changing the membrane fluidity. The aim of this study was to determine the effects of Vitex agnuscastus essential oil on human erythrocyte membrane fluidity at graded depths. We used Electron Paramagnetic Resonance spectroscopy and fatty acid spin probes (5-doxyl stearic acid and 12-doxyl stearic acid), whose spectra depend on membrane fluidity. After treatment with Vitex agnus-castus essential oil the erythrocytes had a significant (p=0.029) and reversible increase in membrane fluidity in the deeper hydrophobic membrane regions, with no change (p>0.05) in fluidity near the membrane's hydrophilic surface. These results document increased fluidity of the human erythrocyte membrane by Vitex agnus-castus essential oil, and this action may be useful in patients with menopause-related hypertension and other cardiovascular conditions.
AB  - Fluidnost membrane eritrocita uslovljava njihove reološke karakteristike, svojevrsne dinamičke kvalitete, izmenjene u hipertenziji i aterosklerozi. Rizik od navedenih i drugih kardiovaskularnih oboljenja se kod žena povećava sa starenjem. Tegobe koje prate menopauzu se obično ublažavaju supstitucionom hormonskom terapijom, koja može povećati rizik od pojave malignih oboljenja. Esencijalno ulje biljke Vitex agnus-castus L. sadrži različita organska jedinjenja (monoterpene, seskviterpene i terpenoide) i sve češće se koristi kao alternativno terapijsko sredstvo za simptome menopauze. Navedene komponente esencijalnog ulja mogu se ugraditi u ćelijske membrane i menjati njihovu fluidnost. Cilj studije bio je da se utvrde efekti esencijalnog ulja biljke Vitex agnus-castus na fluidnost membrane eritrocita po njenoj du bini. Korišćena je spektroskopija elektronske paramagnetne rezonance i masnokiselinske spinske probe (5-doksil stearinska i 12-doksil stearinska kiselina), čiji spektri za vise od fluidnosti membrane. Nakon tretmana eritrocita esencijalnim uljem biljke Vitex agnus-castus utvrđeno je značajno (p=0,029) i reverzibilno povećanje fluidnosti njihove membrane u dubljim, hidrofobnim regionima, dok u površinskim, hidrofilnim regionima eritrocitne membrane nisu utvrđene značajne promene (p>0,05). Ovi rezultati ukazuju na povećanje fluidnosti eritrocitne membrane nakon tretmana esencijalnim uljem biljke Vitex agnus-castus, što može biti koristan efekat pri tretmanu pacijentkinja sa hipertenzijom i drugim kardiovaskularnim oboljenjima u menopauzi.
PB  - Belgrade: Society of Medical Biochemists of Serbia
T2  - Journal of Medical Biochemistry
T1  - Esencijalno ulje biljke Vitex agnus-castus L. - povećava fluidnost eritrocitne membrane
T1  - Vitex agnus-castus L.: Essential oil increases human erythrocyte membrane fluidity
IS  - 3
VL  - 31
DO  - 10.2478/v10011-011-0055-x
SP  - 222
EP  - 227
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_498
ER  - 

@article{
author = "Ajdžanović, Vladimir and Spasojević, Ivan and Živanović, Jasmina and Šošić-Jurjević, Branka  and Filipović, Branko and Milošević, Verica and Severs, Walter",
year = "2012, 2012",
abstract = "Erythrocyte membrane fluidity is related to their rheologic behavior, the dynamic quality of erythrocytes, which is tempted in hypertension and atherosclerosis. An increased risk of these and other cardiovascular diseases occurs in ageing women. Menopause-related conditions are often treated with hormone replacement therapy that may increase the risk of malignancies. Vitex agnus-castus L. essential oil contains various organic compounds (monoterpenes, sesquiterpenes and terpenoids), and is increasingly used as an alternative therapy for menopausal symptoms. These components of the oil may be incorporated into cell membranes, thereby changing the membrane fluidity. The aim of this study was to determine the effects of Vitex agnuscastus essential oil on human erythrocyte membrane fluidity at graded depths. We used Electron Paramagnetic Resonance spectroscopy and fatty acid spin probes (5-doxyl stearic acid and 12-doxyl stearic acid), whose spectra depend on membrane fluidity. After treatment with Vitex agnus-castus essential oil the erythrocytes had a significant (p=0.029) and reversible increase in membrane fluidity in the deeper hydrophobic membrane regions, with no change (p>0.05) in fluidity near the membrane's hydrophilic surface. These results document increased fluidity of the human erythrocyte membrane by Vitex agnus-castus essential oil, and this action may be useful in patients with menopause-related hypertension and other cardiovascular conditions., Fluidnost membrane eritrocita uslovljava njihove reološke karakteristike, svojevrsne dinamičke kvalitete, izmenjene u hipertenziji i aterosklerozi. Rizik od navedenih i drugih kardiovaskularnih oboljenja se kod žena povećava sa starenjem. Tegobe koje prate menopauzu se obično ublažavaju supstitucionom hormonskom terapijom, koja može povećati rizik od pojave malignih oboljenja. Esencijalno ulje biljke Vitex agnus-castus L. sadrži različita organska jedinjenja (monoterpene, seskviterpene i terpenoide) i sve češće se koristi kao alternativno terapijsko sredstvo za simptome menopauze. Navedene komponente esencijalnog ulja mogu se ugraditi u ćelijske membrane i menjati njihovu fluidnost. Cilj studije bio je da se utvrde efekti esencijalnog ulja biljke Vitex agnus-castus na fluidnost membrane eritrocita po njenoj du bini. Korišćena je spektroskopija elektronske paramagnetne rezonance i masnokiselinske spinske probe (5-doksil stearinska i 12-doksil stearinska kiselina), čiji spektri za vise od fluidnosti membrane. Nakon tretmana eritrocita esencijalnim uljem biljke Vitex agnus-castus utvrđeno je značajno (p=0,029) i reverzibilno povećanje fluidnosti njihove membrane u dubljim, hidrofobnim regionima, dok u površinskim, hidrofilnim regionima eritrocitne membrane nisu utvrđene značajne promene (p>0,05). Ovi rezultati ukazuju na povećanje fluidnosti eritrocitne membrane nakon tretmana esencijalnim uljem biljke Vitex agnus-castus, što može biti koristan efekat pri tretmanu pacijentkinja sa hipertenzijom i drugim kardiovaskularnim oboljenjima u menopauzi.",
publisher = "Belgrade: Society of Medical Biochemists of Serbia",
journal = "Journal of Medical Biochemistry",
title = "Esencijalno ulje biljke Vitex agnus-castus L. - povećava fluidnost eritrocitne membrane, Vitex agnus-castus L.: Essential oil increases human erythrocyte membrane fluidity",
number = "3",
volume = "31",
doi = "10.2478/v10011-011-0055-x",
pages = "222-227",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_498"
}

Ajdžanović, V., Spasojević, I., Živanović, J., Šošić-Jurjević, B., Filipović, B., Milošević, V.,& Severs, W.. (2012). Esencijalno ulje biljke Vitex agnus-castus L. - povećava fluidnost eritrocitne membrane. in Journal of Medical Biochemistry
Belgrade: Society of Medical Biochemists of Serbia., 31(3), 222-227.
https://doi.org/10.2478/v10011-011-0055-x
https://hdl.handle.net/21.15107/rcub_ibiss_498

Ajdžanović V, Spasojević I, Živanović J, Šošić-Jurjević B, Filipović B, Milošević V, Severs W. Esencijalno ulje biljke Vitex agnus-castus L. - povećava fluidnost eritrocitne membrane. in Journal of Medical Biochemistry. 2012;31(3):222-227.
doi:10.2478/v10011-011-0055-x
https://hdl.handle.net/21.15107/rcub_ibiss_498 .

Ajdžanović, Vladimir, Spasojević, Ivan, Živanović, Jasmina, Šošić-Jurjević, Branka , Filipović, Branko, Milošević, Verica, Severs, Walter, "Esencijalno ulje biljke Vitex agnus-castus L. - povećava fluidnost eritrocitne membrane" in Journal of Medical Biochemistry, 31, no. 3 (2012):222-227,
https://doi.org/10.2478/v10011-011-0055-x .,
https://hdl.handle.net/21.15107/rcub_ibiss_498 .