TY  - JOUR
AU  - Xavier, Cristina P R
AU  - Pešić, Milica
AU  - Helena Vasconcelos, M.
PY  - 2016
UR  - http://www.eurekaselect.com/136935/article
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2976
AB  - Despite the enormous number of anticancer drugs presently available in the clinic, treatment failure due to drug resistance is very frequent. The identification of mechanisms of resistance to different drugs is necessary, in order to identify ways to prevent and circumvent such resistance. Indeed, the identification of novel therapeutic targets to overcome cancer drug resistance remains one of the major challenges in drug discovery and development. The methods employed to identify drug resistance mechanisms and novel therapeutic targets depend greatly on the establishment of cancer drug resistant cell lines. The establishment of such drug resistant cell lines is laborious and time-consuming and various different approaches have been described. This manuscript reviews the methodologies that have been used to create cancer drug resistant cell lines and to identify their mechanisms of resistance. In addition, this review highlights the most frequent drug resistance mechanisms found in cancer cells.
PB  - Bentham Science Publishers B.V.
T2  - Current Cancer Drug Targets
T1  - Understanding cancer drug resistance by developing and studying resistant cell line models
IS  - 3
VL  - 16
DO  - 10.2174/1568009616666151113120705
SP  - 226
EP  - 237
ER  - 

@article{
author = "Xavier, Cristina P R and Pešić, Milica and Helena Vasconcelos, M.",
year = "2016",
abstract = "Despite the enormous number of anticancer drugs presently available in the clinic, treatment failure due to drug resistance is very frequent. The identification of mechanisms of resistance to different drugs is necessary, in order to identify ways to prevent and circumvent such resistance. Indeed, the identification of novel therapeutic targets to overcome cancer drug resistance remains one of the major challenges in drug discovery and development. The methods employed to identify drug resistance mechanisms and novel therapeutic targets depend greatly on the establishment of cancer drug resistant cell lines. The establishment of such drug resistant cell lines is laborious and time-consuming and various different approaches have been described. This manuscript reviews the methodologies that have been used to create cancer drug resistant cell lines and to identify their mechanisms of resistance. In addition, this review highlights the most frequent drug resistance mechanisms found in cancer cells.",
publisher = "Bentham Science Publishers B.V.",
journal = "Current Cancer Drug Targets",
title = "Understanding cancer drug resistance by developing and studying resistant cell line models",
number = "3",
volume = "16",
doi = "10.2174/1568009616666151113120705",
pages = "226-237"
}

Xavier, C. P. R., Pešić, M.,& Helena Vasconcelos, M.. (2016). Understanding cancer drug resistance by developing and studying resistant cell line models. in Current Cancer Drug Targets
Bentham Science Publishers B.V.., 16(3), 226-237.
https://doi.org/10.2174/1568009616666151113120705

Xavier CPR, Pešić M, Helena Vasconcelos M. Understanding cancer drug resistance by developing and studying resistant cell line models. in Current Cancer Drug Targets. 2016;16(3):226-237.
doi:10.2174/1568009616666151113120705 .

Xavier, Cristina P R, Pešić, Milica, Helena Vasconcelos, M., "Understanding cancer drug resistance by developing and studying resistant cell line models" in Current Cancer Drug Targets, 16, no. 3 (2016):226-237,
https://doi.org/10.2174/1568009616666151113120705 . .

TY  - JOUR
AU  - Ferreira, Isabel C. F. R.
AU  - Heleno, Sandrina A.
AU  - Reis, Filipa S.
AU  - Stojković, Dejan
AU  - Queiroz, Maria Joao R. P.
AU  - Helena Vasconcelos, M.
AU  - Soković, Marina
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1948
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3526
AB  - Ganoderma genus comprises one of the most commonly studied species   worldwide, Ganoderma lucidum. However, other Ganoderma species have been   also reported as important sources of bioactive compounds.   Polysaccharides are important contributors to the medicinal properties   reported for Ganoderma species, as demonstrated by the numerous   publications, including reviews, on this matter. Yet, what are the   chemical features of Ganoderma polysaccharides that have bioactivity? In   the present manuscript, the chemical features of Ganoderma   polysaccharides with reported antioxidant, antitumor and antimicrobial   activities (the most studied worldwide) are analyzed in detail. The   composition of sugars (homo- versus hetero-glucans and other   polysaccharides), type of glycosidic linkages, branching patterns, and   linkage to proteins are discussed. Methods for extraction, isolation and   identification are evaluated and, finally, the bioactivity of   polysaccharidic extracts and purified compounds are discussed. The   integration of data allows deduction of structure-activity relationships   and gives clues to the chemical aspects involved in Ganoderma   bioactivity. (C) 2014 Elsevier Ltd. All rights reserved.
T2  - Phytochemistry
T1  - Chemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activities
IS  - SI
VL  - 114
DO  - 10.1016/j.phytochem.2014.10.011
SP  - 38
EP  - 55
ER  - 

@article{
author = "Ferreira, Isabel C. F. R. and Heleno, Sandrina A. and Reis, Filipa S. and Stojković, Dejan and Queiroz, Maria Joao R. P. and Helena Vasconcelos, M. and Soković, Marina",
year = "2015",
abstract = "Ganoderma genus comprises one of the most commonly studied species   worldwide, Ganoderma lucidum. However, other Ganoderma species have been   also reported as important sources of bioactive compounds.   Polysaccharides are important contributors to the medicinal properties   reported for Ganoderma species, as demonstrated by the numerous   publications, including reviews, on this matter. Yet, what are the   chemical features of Ganoderma polysaccharides that have bioactivity? In   the present manuscript, the chemical features of Ganoderma   polysaccharides with reported antioxidant, antitumor and antimicrobial   activities (the most studied worldwide) are analyzed in detail. The   composition of sugars (homo- versus hetero-glucans and other   polysaccharides), type of glycosidic linkages, branching patterns, and   linkage to proteins are discussed. Methods for extraction, isolation and   identification are evaluated and, finally, the bioactivity of   polysaccharidic extracts and purified compounds are discussed. The   integration of data allows deduction of structure-activity relationships   and gives clues to the chemical aspects involved in Ganoderma   bioactivity. (C) 2014 Elsevier Ltd. All rights reserved.",
journal = "Phytochemistry",
title = "Chemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activities",
number = "SI",
volume = "114",
doi = "10.1016/j.phytochem.2014.10.011",
pages = "38-55"
}

Ferreira, I. C. F. R., Heleno, S. A., Reis, F. S., Stojković, D., Queiroz, M. J. R. P., Helena Vasconcelos, M.,& Soković, M.. (2015). Chemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activities. in Phytochemistry, 114(SI), 38-55.
https://doi.org/10.1016/j.phytochem.2014.10.011

Ferreira ICFR, Heleno SA, Reis FS, Stojković D, Queiroz MJRP, Helena Vasconcelos M, Soković M. Chemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activities. in Phytochemistry. 2015;114(SI):38-55.
doi:10.1016/j.phytochem.2014.10.011 .

Ferreira, Isabel C. F. R., Heleno, Sandrina A., Reis, Filipa S., Stojković, Dejan, Queiroz, Maria Joao R. P., Helena Vasconcelos, M., Soković, Marina, "Chemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activities" in Phytochemistry, 114, no. SI (2015):38-55,
https://doi.org/10.1016/j.phytochem.2014.10.011 . .

TY  - JOUR
AU  - Ferreira, Isabel C. F. R.
AU  - Heleno, Sandrina A.
AU  - Reis, Filipa S.
AU  - Stojković, Dejan
AU  - Queiroz, Maria Joao R. P.
AU  - Helena Vasconcelos, M.
AU  - Soković, Marina
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1948
AB  - Ganoderma genus comprises one of the most commonly studied species
   worldwide, Ganoderma lucidum. However, other Ganoderma species have been
   also reported as important sources of bioactive compounds.
   Polysaccharides are important contributors to the medicinal properties
   reported for Ganoderma species, as demonstrated by the numerous
   publications, including reviews, on this matter. Yet, what are the
   chemical features of Ganoderma polysaccharides that have bioactivity? In
   the present manuscript, the chemical features of Ganoderma
   polysaccharides with reported antioxidant, antitumor and antimicrobial
   activities (the most studied worldwide) are analyzed in detail. The
   composition of sugars (homo- versus hetero-glucans and other
   polysaccharides), type of glycosidic linkages, branching patterns, and
   linkage to proteins are discussed. Methods for extraction, isolation and
   identification are evaluated and, finally, the bioactivity of
   polysaccharidic extracts and purified compounds are discussed. The
   integration of data allows deduction of structure-activity relationships
   and gives clues to the chemical aspects involved in Ganoderma
   bioactivity. (C) 2014 Elsevier Ltd. All rights reserved.
T2  - Phytochemistry
T1  - Chemical features of Ganoderma polysaccharides with antioxidant,
 antitumor and antimicrobial activities
IS  - SI
VL  - 114
DO  - 10.1016/j.phytochem.2014.10.011
SP  - 38
EP  - 55
ER  - 

@article{
author = "Ferreira, Isabel C. F. R. and Heleno, Sandrina A. and Reis, Filipa S. and Stojković, Dejan and Queiroz, Maria Joao R. P. and Helena Vasconcelos, M. and Soković, Marina",
year = "2015",
abstract = "Ganoderma genus comprises one of the most commonly studied species
   worldwide, Ganoderma lucidum. However, other Ganoderma species have been
   also reported as important sources of bioactive compounds.
   Polysaccharides are important contributors to the medicinal properties
   reported for Ganoderma species, as demonstrated by the numerous
   publications, including reviews, on this matter. Yet, what are the
   chemical features of Ganoderma polysaccharides that have bioactivity? In
   the present manuscript, the chemical features of Ganoderma
   polysaccharides with reported antioxidant, antitumor and antimicrobial
   activities (the most studied worldwide) are analyzed in detail. The
   composition of sugars (homo- versus hetero-glucans and other
   polysaccharides), type of glycosidic linkages, branching patterns, and
   linkage to proteins are discussed. Methods for extraction, isolation and
   identification are evaluated and, finally, the bioactivity of
   polysaccharidic extracts and purified compounds are discussed. The
   integration of data allows deduction of structure-activity relationships
   and gives clues to the chemical aspects involved in Ganoderma
   bioactivity. (C) 2014 Elsevier Ltd. All rights reserved.",
journal = "Phytochemistry",
title = "Chemical features of Ganoderma polysaccharides with antioxidant,
 antitumor and antimicrobial activities",
number = "SI",
volume = "114",
doi = "10.1016/j.phytochem.2014.10.011",
pages = "38-55"
}

Ferreira, I. C. F. R., Heleno, S. A., Reis, F. S., Stojković, D., Queiroz, M. J. R. P., Helena Vasconcelos, M.,& Soković, M.. (2015). Chemical features of Ganoderma polysaccharides with antioxidant,
 antitumor and antimicrobial activities. in Phytochemistry, 114(SI), 38-55.
https://doi.org/10.1016/j.phytochem.2014.10.011

Ferreira ICFR, Heleno SA, Reis FS, Stojković D, Queiroz MJRP, Helena Vasconcelos M, Soković M. Chemical features of Ganoderma polysaccharides with antioxidant,
 antitumor and antimicrobial activities. in Phytochemistry. 2015;114(SI):38-55.
doi:10.1016/j.phytochem.2014.10.011 .

Ferreira, Isabel C. F. R., Heleno, Sandrina A., Reis, Filipa S., Stojković, Dejan, Queiroz, Maria Joao R. P., Helena Vasconcelos, M., Soković, Marina, "Chemical features of Ganoderma polysaccharides with antioxidant,
 antitumor and antimicrobial activities" in Phytochemistry, 114, no. SI (2015):38-55,
https://doi.org/10.1016/j.phytochem.2014.10.011 . .