TY  - JOUR
AU  - Tratrat, Christophe
AU  - Haroun, Michelyne
AU  - Paparisva, Aliki
AU  - Geronikaki, Athina
AU  - Camoutsis, Charalabos
AU  - Ćirić, Ana
AU  - Glamočlija, Jasmina
AU  - Soković, Marina
AU  - Fotakis, Charalmpos
AU  - Zoumpoulakis, Panagiotis
AU  - Bhunia, Shome
AU  - Saxena, Anil
PY  - 2018
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4306
AB  - As a part of our ongoing studies in developing new derivatives as antimicrobial agents we
describe the synthesis of novel substituted 5-benzylideno-2-adamantylthiazol[3,2-b][1,2,4]triazol-6
(5H)ones.The twenty-five newly synthesized compounds were tested for their antimicrobial and
antifungal activity. All compounds have shown antibacterial properties with compounds 1–9 showing
the lowest activity, followed by compounds 10–14 while compounds 15–25 the highest antibacterial
activity. Specific compounds appeared to be more active than ampicillin in most studied
strains and in some cases more active than streptomycin. Antifungal activity in most cases also
was better than that of reference drugs ketoconazole and bifonazole. Elucidating the relation of molecular properties to antimicrobial activity as well as generation of pharmacophore model for
antifungal activity of two fungal species Aspergillus fumigatus and Candida albicans were performed.
PB  - Elsevier B.V. on behalf of King Saud University
T2  - Arabian Journal of Chemistry
T1  - Design, synthesis and biological evaluation of new substituted 5-benzylideno-2-adamantylthiazol[3,2- b][1,2,4]triazol-6(5H)ones. Pharmacophore models for antifungal activity
IS  - 4
VL  - 11
DO  - 10.1016/j.arabjc.2016.06.007
SP  - 573
EP  - 590
ER  - 

@article{
author = "Tratrat, Christophe and Haroun, Michelyne and Paparisva, Aliki and Geronikaki, Athina and Camoutsis, Charalabos and Ćirić, Ana and Glamočlija, Jasmina and Soković, Marina and Fotakis, Charalmpos and Zoumpoulakis, Panagiotis and Bhunia, Shome and Saxena, Anil",
year = "2018",
abstract = "As a part of our ongoing studies in developing new derivatives as antimicrobial agents we
describe the synthesis of novel substituted 5-benzylideno-2-adamantylthiazol[3,2-b][1,2,4]triazol-6
(5H)ones.The twenty-five newly synthesized compounds were tested for their antimicrobial and
antifungal activity. All compounds have shown antibacterial properties with compounds 1–9 showing
the lowest activity, followed by compounds 10–14 while compounds 15–25 the highest antibacterial
activity. Specific compounds appeared to be more active than ampicillin in most studied
strains and in some cases more active than streptomycin. Antifungal activity in most cases also
was better than that of reference drugs ketoconazole and bifonazole. Elucidating the relation of molecular properties to antimicrobial activity as well as generation of pharmacophore model for
antifungal activity of two fungal species Aspergillus fumigatus and Candida albicans were performed.",
publisher = "Elsevier B.V. on behalf of King Saud University",
journal = "Arabian Journal of Chemistry",
title = "Design, synthesis and biological evaluation of new substituted 5-benzylideno-2-adamantylthiazol[3,2- b][1,2,4]triazol-6(5H)ones. Pharmacophore models for antifungal activity",
number = "4",
volume = "11",
doi = "10.1016/j.arabjc.2016.06.007",
pages = "573-590"
}

Tratrat, C., Haroun, M., Paparisva, A., Geronikaki, A., Camoutsis, C., Ćirić, A., Glamočlija, J., Soković, M., Fotakis, C., Zoumpoulakis, P., Bhunia, S.,& Saxena, A.. (2018). Design, synthesis and biological evaluation of new substituted 5-benzylideno-2-adamantylthiazol[3,2- b][1,2,4]triazol-6(5H)ones. Pharmacophore models for antifungal activity. in Arabian Journal of Chemistry
Elsevier B.V. on behalf of King Saud University., 11(4), 573-590.
https://doi.org/10.1016/j.arabjc.2016.06.007

Tratrat C, Haroun M, Paparisva A, Geronikaki A, Camoutsis C, Ćirić A, Glamočlija J, Soković M, Fotakis C, Zoumpoulakis P, Bhunia S, Saxena A. Design, synthesis and biological evaluation of new substituted 5-benzylideno-2-adamantylthiazol[3,2- b][1,2,4]triazol-6(5H)ones. Pharmacophore models for antifungal activity. in Arabian Journal of Chemistry. 2018;11(4):573-590.
doi:10.1016/j.arabjc.2016.06.007 .

Tratrat, Christophe, Haroun, Michelyne, Paparisva, Aliki, Geronikaki, Athina, Camoutsis, Charalabos, Ćirić, Ana, Glamočlija, Jasmina, Soković, Marina, Fotakis, Charalmpos, Zoumpoulakis, Panagiotis, Bhunia, Shome, Saxena, Anil, "Design, synthesis and biological evaluation of new substituted 5-benzylideno-2-adamantylthiazol[3,2- b][1,2,4]triazol-6(5H)ones. Pharmacophore models for antifungal activity" in Arabian Journal of Chemistry, 11, no. 4 (2018):573-590,
https://doi.org/10.1016/j.arabjc.2016.06.007 . .

TY  - JOUR
AU  - Omar, Kouatli
AU  - Geronikaki, Athina
AU  - Zoumpoulakis, Panagiotis
AU  - Camoutsis, Charalabos
AU  - Soković, Marina
AU  - Ćirić, Ana
AU  - Glamočlija, Jasmina
PY  - 2010
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3588
AB  - As part of ongoing studies in developing new antimicrobials, a class of structurally novel 4-thiazolidinone derivatives incorporating three known bioactive nuclei such as thiazole, thiazolidinone and adamantane was synthesized by the multi-step reaction protocol, already reported in the literature. NMR and Molecular Modeling techniques were employed for structure elucidation and Z/E potential isomerism configuration of the analogues. Evaluation of antibacterial and antifungal activity showed that almost all compounds exhibited better results than reference drugs thus they could be promising candidates for novel drugs.
PB  - Elsevier BV
T2  - Bioorganic & Medicinal Chemistry
T1  - Novel 4-thiazolidinone derivatives as potential antifungal and antibacterial drugs
IS  - 1
VL  - 18
DO  - 10.1016/j.bmc.2009.10.041
SP  - 426
EP  - 432
ER  - 

@article{
author = "Omar, Kouatli and Geronikaki, Athina and Zoumpoulakis, Panagiotis and Camoutsis, Charalabos and Soković, Marina and Ćirić, Ana and Glamočlija, Jasmina",
year = "2010",
abstract = "As part of ongoing studies in developing new antimicrobials, a class of structurally novel 4-thiazolidinone derivatives incorporating three known bioactive nuclei such as thiazole, thiazolidinone and adamantane was synthesized by the multi-step reaction protocol, already reported in the literature. NMR and Molecular Modeling techniques were employed for structure elucidation and Z/E potential isomerism configuration of the analogues. Evaluation of antibacterial and antifungal activity showed that almost all compounds exhibited better results than reference drugs thus they could be promising candidates for novel drugs.",
publisher = "Elsevier BV",
journal = "Bioorganic & Medicinal Chemistry",
title = "Novel 4-thiazolidinone derivatives as potential antifungal and antibacterial drugs",
number = "1",
volume = "18",
doi = "10.1016/j.bmc.2009.10.041",
pages = "426-432"
}

Omar, K., Geronikaki, A., Zoumpoulakis, P., Camoutsis, C., Soković, M., Ćirić, A.,& Glamočlija, J.. (2010). Novel 4-thiazolidinone derivatives as potential antifungal and antibacterial drugs. in Bioorganic & Medicinal Chemistry
Elsevier BV., 18(1), 426-432.
https://doi.org/10.1016/j.bmc.2009.10.041

Omar K, Geronikaki A, Zoumpoulakis P, Camoutsis C, Soković M, Ćirić A, Glamočlija J. Novel 4-thiazolidinone derivatives as potential antifungal and antibacterial drugs. in Bioorganic & Medicinal Chemistry. 2010;18(1):426-432.
doi:10.1016/j.bmc.2009.10.041 .

Omar, Kouatli, Geronikaki, Athina, Zoumpoulakis, Panagiotis, Camoutsis, Charalabos, Soković, Marina, Ćirić, Ana, Glamočlija, Jasmina, "Novel 4-thiazolidinone derivatives as potential antifungal and antibacterial drugs" in Bioorganic & Medicinal Chemistry, 18, no. 1 (2010):426-432,
https://doi.org/10.1016/j.bmc.2009.10.041 . .

TY  - JOUR
AU  - Ezabadi, Iraj Rahavi
AU  - Camoutsis, Charalabos
AU  - Zoumpoulakis, Panagiotis
AU  - Geronikaki, Athina
AU  - Soković, Marina
AU  - Glamočlija, Jasmina
AU  - Ćirić, Ana
PY  - 2008
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3586
AB  - A series of 10 new 5-[2-(substituted sulfamoyl)-4,5-dimethoxy-benzyl]-4aryl-s-triazole-3-thiones were synthesized and evaluated for in vitro antifungal and antibacterial activity. All compounds tested showed significant antifungal activity against all the micromycetes, compared to the commercial fungicide bifonazole. Differences in their activity depend on the substitution of different reactive groups. More specifically, best antifungal activity among synthetic analogues was shown with N-dimethylsulfamoyl group. All the compounds tested against bacteria showed the same activity as the commercial agent streptomycin, except for Enterobacter cloacce and Salmonella species. Chloramphenicol showed lower bactericidal effect than the synthetic compounds. Furthermore, it is apparent that different compounds reacted in different ways against bacteria. Gram (-) bacteria seem to be more sensitive to these compounds than Gram (+) species. An effort was made to correlate the above-mentioned differences in activity with lipophilicity studies. Furthermore, molecular modeling was used to obtain the main conformational features of this class of molecules for future structure-activity relationship studies.
PB  - Elsevier BV
T2  - Bioorganic & Medicinal Chemistry
T1  - Sulfonamide-1,2,4-triazole derivatives as antifungal and antibacterial agents: Synthesis, biological evaluation, lipophilicity, and conformational studies
IS  - 3
VL  - 16
DO  - 10.1016/j.bmc.2007.10.082
SP  - 1150
EP  - 1161
ER  - 

@article{
author = "Ezabadi, Iraj Rahavi and Camoutsis, Charalabos and Zoumpoulakis, Panagiotis and Geronikaki, Athina and Soković, Marina and Glamočlija, Jasmina and Ćirić, Ana",
year = "2008",
abstract = "A series of 10 new 5-[2-(substituted sulfamoyl)-4,5-dimethoxy-benzyl]-4aryl-s-triazole-3-thiones were synthesized and evaluated for in vitro antifungal and antibacterial activity. All compounds tested showed significant antifungal activity against all the micromycetes, compared to the commercial fungicide bifonazole. Differences in their activity depend on the substitution of different reactive groups. More specifically, best antifungal activity among synthetic analogues was shown with N-dimethylsulfamoyl group. All the compounds tested against bacteria showed the same activity as the commercial agent streptomycin, except for Enterobacter cloacce and Salmonella species. Chloramphenicol showed lower bactericidal effect than the synthetic compounds. Furthermore, it is apparent that different compounds reacted in different ways against bacteria. Gram (-) bacteria seem to be more sensitive to these compounds than Gram (+) species. An effort was made to correlate the above-mentioned differences in activity with lipophilicity studies. Furthermore, molecular modeling was used to obtain the main conformational features of this class of molecules for future structure-activity relationship studies.",
publisher = "Elsevier BV",
journal = "Bioorganic & Medicinal Chemistry",
title = "Sulfonamide-1,2,4-triazole derivatives as antifungal and antibacterial agents: Synthesis, biological evaluation, lipophilicity, and conformational studies",
number = "3",
volume = "16",
doi = "10.1016/j.bmc.2007.10.082",
pages = "1150-1161"
}

Ezabadi, I. R., Camoutsis, C., Zoumpoulakis, P., Geronikaki, A., Soković, M., Glamočlija, J.,& Ćirić, A.. (2008). Sulfonamide-1,2,4-triazole derivatives as antifungal and antibacterial agents: Synthesis, biological evaluation, lipophilicity, and conformational studies. in Bioorganic & Medicinal Chemistry
Elsevier BV., 16(3), 1150-1161.
https://doi.org/10.1016/j.bmc.2007.10.082

Ezabadi IR, Camoutsis C, Zoumpoulakis P, Geronikaki A, Soković M, Glamočlija J, Ćirić A. Sulfonamide-1,2,4-triazole derivatives as antifungal and antibacterial agents: Synthesis, biological evaluation, lipophilicity, and conformational studies. in Bioorganic & Medicinal Chemistry. 2008;16(3):1150-1161.
doi:10.1016/j.bmc.2007.10.082 .

Ezabadi, Iraj Rahavi, Camoutsis, Charalabos, Zoumpoulakis, Panagiotis, Geronikaki, Athina, Soković, Marina, Glamočlija, Jasmina, Ćirić, Ana, "Sulfonamide-1,2,4-triazole derivatives as antifungal and antibacterial agents: Synthesis, biological evaluation, lipophilicity, and conformational studies" in Bioorganic & Medicinal Chemistry, 16, no. 3 (2008):1150-1161,
https://doi.org/10.1016/j.bmc.2007.10.082 . .