TY  - JOUR
AU  - Tratrat, Christophe
AU  - Haroun, Michelyne
AU  - Paparisva, Aliki
AU  - Geronikaki, Athina
AU  - Camoutsis, Charalabos
AU  - Ćirić, Ana
AU  - Glamočlija, Jasmina
AU  - Soković, Marina
AU  - Fotakis, Charalmpos
AU  - Zoumpoulakis, Panagiotis
AU  - Bhunia, Shome
AU  - Saxena, Anil
PY  - 2018
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4306
AB  - As a part of our ongoing studies in developing new derivatives as antimicrobial agents we
describe the synthesis of novel substituted 5-benzylideno-2-adamantylthiazol[3,2-b][1,2,4]triazol-6
(5H)ones.The twenty-five newly synthesized compounds were tested for their antimicrobial and
antifungal activity. All compounds have shown antibacterial properties with compounds 1–9 showing
the lowest activity, followed by compounds 10–14 while compounds 15–25 the highest antibacterial
activity. Specific compounds appeared to be more active than ampicillin in most studied
strains and in some cases more active than streptomycin. Antifungal activity in most cases also
was better than that of reference drugs ketoconazole and bifonazole. Elucidating the relation of molecular properties to antimicrobial activity as well as generation of pharmacophore model for
antifungal activity of two fungal species Aspergillus fumigatus and Candida albicans were performed.
PB  - Elsevier B.V. on behalf of King Saud University
T2  - Arabian Journal of Chemistry
T1  - Design, synthesis and biological evaluation of new substituted 5-benzylideno-2-adamantylthiazol[3,2- b][1,2,4]triazol-6(5H)ones. Pharmacophore models for antifungal activity
IS  - 4
VL  - 11
DO  - 10.1016/j.arabjc.2016.06.007
SP  - 573
EP  - 590
ER  - 

@article{
author = "Tratrat, Christophe and Haroun, Michelyne and Paparisva, Aliki and Geronikaki, Athina and Camoutsis, Charalabos and Ćirić, Ana and Glamočlija, Jasmina and Soković, Marina and Fotakis, Charalmpos and Zoumpoulakis, Panagiotis and Bhunia, Shome and Saxena, Anil",
year = "2018",
abstract = "As a part of our ongoing studies in developing new derivatives as antimicrobial agents we
describe the synthesis of novel substituted 5-benzylideno-2-adamantylthiazol[3,2-b][1,2,4]triazol-6
(5H)ones.The twenty-five newly synthesized compounds were tested for their antimicrobial and
antifungal activity. All compounds have shown antibacterial properties with compounds 1–9 showing
the lowest activity, followed by compounds 10–14 while compounds 15–25 the highest antibacterial
activity. Specific compounds appeared to be more active than ampicillin in most studied
strains and in some cases more active than streptomycin. Antifungal activity in most cases also
was better than that of reference drugs ketoconazole and bifonazole. Elucidating the relation of molecular properties to antimicrobial activity as well as generation of pharmacophore model for
antifungal activity of two fungal species Aspergillus fumigatus and Candida albicans were performed.",
publisher = "Elsevier B.V. on behalf of King Saud University",
journal = "Arabian Journal of Chemistry",
title = "Design, synthesis and biological evaluation of new substituted 5-benzylideno-2-adamantylthiazol[3,2- b][1,2,4]triazol-6(5H)ones. Pharmacophore models for antifungal activity",
number = "4",
volume = "11",
doi = "10.1016/j.arabjc.2016.06.007",
pages = "573-590"
}

Tratrat, C., Haroun, M., Paparisva, A., Geronikaki, A., Camoutsis, C., Ćirić, A., Glamočlija, J., Soković, M., Fotakis, C., Zoumpoulakis, P., Bhunia, S.,& Saxena, A.. (2018). Design, synthesis and biological evaluation of new substituted 5-benzylideno-2-adamantylthiazol[3,2- b][1,2,4]triazol-6(5H)ones. Pharmacophore models for antifungal activity. in Arabian Journal of Chemistry
Elsevier B.V. on behalf of King Saud University., 11(4), 573-590.
https://doi.org/10.1016/j.arabjc.2016.06.007

Tratrat C, Haroun M, Paparisva A, Geronikaki A, Camoutsis C, Ćirić A, Glamočlija J, Soković M, Fotakis C, Zoumpoulakis P, Bhunia S, Saxena A. Design, synthesis and biological evaluation of new substituted 5-benzylideno-2-adamantylthiazol[3,2- b][1,2,4]triazol-6(5H)ones. Pharmacophore models for antifungal activity. in Arabian Journal of Chemistry. 2018;11(4):573-590.
doi:10.1016/j.arabjc.2016.06.007 .

Tratrat, Christophe, Haroun, Michelyne, Paparisva, Aliki, Geronikaki, Athina, Camoutsis, Charalabos, Ćirić, Ana, Glamočlija, Jasmina, Soković, Marina, Fotakis, Charalmpos, Zoumpoulakis, Panagiotis, Bhunia, Shome, Saxena, Anil, "Design, synthesis and biological evaluation of new substituted 5-benzylideno-2-adamantylthiazol[3,2- b][1,2,4]triazol-6(5H)ones. Pharmacophore models for antifungal activity" in Arabian Journal of Chemistry, 11, no. 4 (2018):573-590,
https://doi.org/10.1016/j.arabjc.2016.06.007 . .

TY  - JOUR
AU  - Pitta, Eleni
AU  - Tsolaki, Evangelia
AU  - Geronikaki, Athina
AU  - Petrović, Jovana
AU  - Glamočlija, Jasmina
AU  - Soković, Marina
AU  - Crespan, Emmanuele
AU  - Maga, Giovanni
AU  - Bhunia, Shome S.
AU  - Saxena, Anil K.
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2088
AB  - As a part of our ongoing research in the development of new
   antimicrobials, herein, we report the synthesis of ten compounds which
   combine three bioactive moieties: thiazole, adamantane and
   4-thiazolidinone. Evaluation of their antibacterial activity revealed
   that the newly synthesized compounds exhibited remarkable growth
   inhibition of a wide spectrum of Gram-positive bacteria, Gram-negative
   bacteria and fungi. The majority of the compounds displayed greater
   antibacterial activity than the reference drugs (ampicillin and
   streptomycin), while the antifungal activity was significantly higher
   than that of the reference drugs bifonazole and ketoconazole.
   Additionally, the title compounds were screened for HIV-1 reverse
   transcriptase inhibitory activity, showing no significant activity.
   Moreover, docking studies were performed in order to explore possible
   binding modes at the MurB protein of S. aureus.
T2  - Medchemcomm
T1  - 4-Thiazolidinone derivatives as potent antimicrobial agents:
 microwave-assisted synthesis, biological evaluation and docking studies
IS  - 2
VL  - 6
DO  - 10.1039/c4md00399c
SP  - 319
EP  - 326
ER  - 

@article{
author = "Pitta, Eleni and Tsolaki, Evangelia and Geronikaki, Athina and Petrović, Jovana and Glamočlija, Jasmina and Soković, Marina and Crespan, Emmanuele and Maga, Giovanni and Bhunia, Shome S. and Saxena, Anil K.",
year = "2015",
abstract = "As a part of our ongoing research in the development of new
   antimicrobials, herein, we report the synthesis of ten compounds which
   combine three bioactive moieties: thiazole, adamantane and
   4-thiazolidinone. Evaluation of their antibacterial activity revealed
   that the newly synthesized compounds exhibited remarkable growth
   inhibition of a wide spectrum of Gram-positive bacteria, Gram-negative
   bacteria and fungi. The majority of the compounds displayed greater
   antibacterial activity than the reference drugs (ampicillin and
   streptomycin), while the antifungal activity was significantly higher
   than that of the reference drugs bifonazole and ketoconazole.
   Additionally, the title compounds were screened for HIV-1 reverse
   transcriptase inhibitory activity, showing no significant activity.
   Moreover, docking studies were performed in order to explore possible
   binding modes at the MurB protein of S. aureus.",
journal = "Medchemcomm",
title = "4-Thiazolidinone derivatives as potent antimicrobial agents:
 microwave-assisted synthesis, biological evaluation and docking studies",
number = "2",
volume = "6",
doi = "10.1039/c4md00399c",
pages = "319-326"
}

Pitta, E., Tsolaki, E., Geronikaki, A., Petrović, J., Glamočlija, J., Soković, M., Crespan, E., Maga, G., Bhunia, S. S.,& Saxena, A. K.. (2015). 4-Thiazolidinone derivatives as potent antimicrobial agents:
 microwave-assisted synthesis, biological evaluation and docking studies. in Medchemcomm, 6(2), 319-326.
https://doi.org/10.1039/c4md00399c

Pitta E, Tsolaki E, Geronikaki A, Petrović J, Glamočlija J, Soković M, Crespan E, Maga G, Bhunia SS, Saxena AK. 4-Thiazolidinone derivatives as potent antimicrobial agents:
 microwave-assisted synthesis, biological evaluation and docking studies. in Medchemcomm. 2015;6(2):319-326.
doi:10.1039/c4md00399c .

Pitta, Eleni, Tsolaki, Evangelia, Geronikaki, Athina, Petrović, Jovana, Glamočlija, Jasmina, Soković, Marina, Crespan, Emmanuele, Maga, Giovanni, Bhunia, Shome S., Saxena, Anil K., "4-Thiazolidinone derivatives as potent antimicrobial agents:
 microwave-assisted synthesis, biological evaluation and docking studies" in Medchemcomm, 6, no. 2 (2015):319-326,
https://doi.org/10.1039/c4md00399c . .