TY  - CONF
AU  - Zavišić, Gordana
AU  - Ristić, Slavica
AU  - Petković, Branka
AU  - Janković, Drina
PY  - 2023
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6538
AB  - Considering the importance of the microbiological correctness of food 
from the aspect of health safety and the most common causes of food contamination 
(bacteria) – the causes of alimentary intoxications and toxoinfections in humans, 
whether sporadic or epidemic, this work aims to analyze and sublimate the most 
common bacterial species isolated from contaminated food and biological samples of 
individuals with alimentary intoxication or toxoinfection. At the global level and 
especially based on the cases reported by the European Center for Disease Control and 
Prevention (ECDC) and the World Health Organization (WHO) for 2022, a trend of 
increasing epidemics caused by microbiologically contaminated food has been 
observed. The latest data from the U.S. Food and Drug Administration (FDA) and 
ECDC show that epidemics caused by Salmonella typhimurium, Escherichia coli, 
Yersinia spp., and Campylobacter spp. are increasing compared with 2021. The highest 
reporting rate was among young children aged 0 to 4 years. The most common 
pathogens are Salmonella Enteritidis and Salmonella Typhimurium, resulting in 61,236 
cases of salmonellosis reported in 30 countries, 14% more than in 2020 (53,163 cases). 
In 2021, there were 6,534 cases of Shiga toxin-producing E. coli infection compared 
with 4,824 in 2020. Similarly, Yersinia spp. and most commonly Y. enterocolitica 
caused 6,876 cases of yersiniosis in 2021 compared with 5,747 in 2020, and also 
deaths. The conclusion is that eggs and egg products remain the most dangerous foods 
in epidemics, but several major incidents have been linked to contaminated vegetables 
(especially lettuce), fruits, and sesame seeds. To prove the genetic link, i.e., that the 
bacteria have the same origin in different sick individuals, the entire genome must be 
sequenced. In the suppressing epidemics, food storage and preservation conditions, 
lettuce washing, handling-washing, cleaning and disinfection in food preparation 
areas, and distribution are of particular importance.
PB  - Prijedor: Public Institution College of Health Sciences
C3  - 2nd International Conference: Knowledge to Health: SANUS 2023. Book 2, Proceedings; 2023 Jun 23-24; Prijedor, Bosnia and Herzegovina
T1  - Microbiological quality and the most common food contaminants
DO  - 10.7251/ZSAN2302261Z
SP  - 261
EP  - 270
ER  - 

@conference{
author = "Zavišić, Gordana and Ristić, Slavica and Petković, Branka and Janković, Drina",
year = "2023",
abstract = "Considering the importance of the microbiological correctness of food 
from the aspect of health safety and the most common causes of food contamination 
(bacteria) – the causes of alimentary intoxications and toxoinfections in humans, 
whether sporadic or epidemic, this work aims to analyze and sublimate the most 
common bacterial species isolated from contaminated food and biological samples of 
individuals with alimentary intoxication or toxoinfection. At the global level and 
especially based on the cases reported by the European Center for Disease Control and 
Prevention (ECDC) and the World Health Organization (WHO) for 2022, a trend of 
increasing epidemics caused by microbiologically contaminated food has been 
observed. The latest data from the U.S. Food and Drug Administration (FDA) and 
ECDC show that epidemics caused by Salmonella typhimurium, Escherichia coli, 
Yersinia spp., and Campylobacter spp. are increasing compared with 2021. The highest 
reporting rate was among young children aged 0 to 4 years. The most common 
pathogens are Salmonella Enteritidis and Salmonella Typhimurium, resulting in 61,236 
cases of salmonellosis reported in 30 countries, 14% more than in 2020 (53,163 cases). 
In 2021, there were 6,534 cases of Shiga toxin-producing E. coli infection compared 
with 4,824 in 2020. Similarly, Yersinia spp. and most commonly Y. enterocolitica 
caused 6,876 cases of yersiniosis in 2021 compared with 5,747 in 2020, and also 
deaths. The conclusion is that eggs and egg products remain the most dangerous foods 
in epidemics, but several major incidents have been linked to contaminated vegetables 
(especially lettuce), fruits, and sesame seeds. To prove the genetic link, i.e., that the 
bacteria have the same origin in different sick individuals, the entire genome must be 
sequenced. In the suppressing epidemics, food storage and preservation conditions, 
lettuce washing, handling-washing, cleaning and disinfection in food preparation 
areas, and distribution are of particular importance.",
publisher = "Prijedor: Public Institution College of Health Sciences",
journal = "2nd International Conference: Knowledge to Health: SANUS 2023. Book 2, Proceedings; 2023 Jun 23-24; Prijedor, Bosnia and Herzegovina",
title = "Microbiological quality and the most common food contaminants",
doi = "10.7251/ZSAN2302261Z",
pages = "261-270"
}

Zavišić, G., Ristić, S., Petković, B.,& Janković, D.. (2023). Microbiological quality and the most common food contaminants. in 2nd International Conference: Knowledge to Health: SANUS 2023. Book 2, Proceedings; 2023 Jun 23-24; Prijedor, Bosnia and Herzegovina
Prijedor: Public Institution College of Health Sciences., 261-270.
https://doi.org/10.7251/ZSAN2302261Z

Zavišić G, Ristić S, Petković B, Janković D. Microbiological quality and the most common food contaminants. in 2nd International Conference: Knowledge to Health: SANUS 2023. Book 2, Proceedings; 2023 Jun 23-24; Prijedor, Bosnia and Herzegovina. 2023;:261-270.
doi:10.7251/ZSAN2302261Z .

Zavišić, Gordana, Ristić, Slavica, Petković, Branka, Janković, Drina, "Microbiological quality and the most common food contaminants" in 2nd International Conference: Knowledge to Health: SANUS 2023. Book 2, Proceedings; 2023 Jun 23-24; Prijedor, Bosnia and Herzegovina (2023):261-270,
https://doi.org/10.7251/ZSAN2302261Z . .

TY  - JOUR
AU  - Zavišić, Gordana
AU  - Ristić, Slavica
AU  - Petković, Branka
AU  - Živkov Šaponja, Dragoslava
AU  - Jojić, Nikola
AU  - Janković, Drina
PY  - 2023
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5752
AB  - Microorganisms used as probiotics should meet elementary safety aspects (non-toxicity, absence of antibiotic resistance genes and translocation) and functional/technological aspects (resistance and survival in the acid gastric environment, adhesiveness, stability, and cell viability). Probiotics with the health claim of being a dietary product or a pharmabiotic (drug category) should be clinically tested, validated, documented, and continuously controlled for quality. Important quality parameters include the identification of declared probiotic strains, the number of viable microorganisms (probiotic bacteria and/or fungi), and microbiological purity (absence of specified pathogenic/opportunistic pathogenic bacteria and fungi, and limitation of total unspecified contaminants such as aerobic bacteria, yeasts, and molds). Due to numerous reports of low-quality commercial probiotics marketed for human use, this review discusses the methods used to test the
probiotic microorganism content, safety for the intended use, and proven health benefits of those probiotics whose microbiological quality deviates from the manufacturer’s stated content, as well as the maintenance of cell viability, i.e., stability of the probiotic during the shelf life. In addition, the adverse effects of probiotics and the potential hazards to the health of the user are addressed.
AB  - Mikroorganizmi koji se koriste kao probiotici treba da zadovolje elementarne aspekte
bezbednosti (netoksičnost, odsustvo gena rezistencije na antibiotike i translokacije) i
funkcionalne/tehnološke aspekte (otpornost i preživljavanje u kiselom gastričnom okruženju, adhezivnost, stabilnost i vijabilnost ćelija). Probiotici sa zdravstvenom tvrdnjom, bilo da su
dijetetski proizvod ili farmabiotik (kategorija lekova), treba da budu klinički testirani, validirani,
dokumentovani i stalno kontrolisani u pogledu kvaliteta. Važni parametri kvaliteta su
identifikacija deklarisanih probiotičkih sojeva, broj živih mikroorganizama (probiotičke bakterije i/ili gljivice) i mikrobiološka čistoća (odsustvo specifičnih patogenih/uslovno patogenih bakterija i gljivica, kao i ograničavanje ukupnog broja kontaminanata kao što su aerobne bakterije, kvasci i plesni). Zbog brojnih izveštaja o komercijalnim probioticima niskog kvaliteta koji se prodaju za ljudsku upotrebu, ovaj pregled razmatra metode koje se koriste za testiranje sadržaja probiotičkih mikroorganizama, bezbednost za nameravanu upotrebu i dokazane zdravstvene koristi onih probiotika čiji mikrobiološki kvalitet odstupa od sadržaja koji tvrde proizvođači i održavanja vitalnosti ćelija, tj. stabilnosti probiotika tokom roka trajanja. Pored toga, razmatraju se i neželjeni efekti probiotika i potencijalne opasnosti po zdravlje korisnika.
PB  - Belgrade: Pharmaceutical Association of Serbia
T2  - Arhiv za Farmaciju
T1  - Microbiological Quality of Probiotic Products
T1  - Mikrobiološki kvalitet probiotičkih proizvoda
IS  - 1
VL  - 73
DO  - 10.5937/arhfarm73-42160
SP  - 17
EP  - 34
ER  - 

@article{
author = "Zavišić, Gordana and Ristić, Slavica and Petković, Branka and Živkov Šaponja, Dragoslava and Jojić, Nikola and Janković, Drina",
year = "2023",
abstract = "Microorganisms used as probiotics should meet elementary safety aspects (non-toxicity, absence of antibiotic resistance genes and translocation) and functional/technological aspects (resistance and survival in the acid gastric environment, adhesiveness, stability, and cell viability). Probiotics with the health claim of being a dietary product or a pharmabiotic (drug category) should be clinically tested, validated, documented, and continuously controlled for quality. Important quality parameters include the identification of declared probiotic strains, the number of viable microorganisms (probiotic bacteria and/or fungi), and microbiological purity (absence of specified pathogenic/opportunistic pathogenic bacteria and fungi, and limitation of total unspecified contaminants such as aerobic bacteria, yeasts, and molds). Due to numerous reports of low-quality commercial probiotics marketed for human use, this review discusses the methods used to test the
probiotic microorganism content, safety for the intended use, and proven health benefits of those probiotics whose microbiological quality deviates from the manufacturer’s stated content, as well as the maintenance of cell viability, i.e., stability of the probiotic during the shelf life. In addition, the adverse effects of probiotics and the potential hazards to the health of the user are addressed., Mikroorganizmi koji se koriste kao probiotici treba da zadovolje elementarne aspekte
bezbednosti (netoksičnost, odsustvo gena rezistencije na antibiotike i translokacije) i
funkcionalne/tehnološke aspekte (otpornost i preživljavanje u kiselom gastričnom okruženju, adhezivnost, stabilnost i vijabilnost ćelija). Probiotici sa zdravstvenom tvrdnjom, bilo da su
dijetetski proizvod ili farmabiotik (kategorija lekova), treba da budu klinički testirani, validirani,
dokumentovani i stalno kontrolisani u pogledu kvaliteta. Važni parametri kvaliteta su
identifikacija deklarisanih probiotičkih sojeva, broj živih mikroorganizama (probiotičke bakterije i/ili gljivice) i mikrobiološka čistoća (odsustvo specifičnih patogenih/uslovno patogenih bakterija i gljivica, kao i ograničavanje ukupnog broja kontaminanata kao što su aerobne bakterije, kvasci i plesni). Zbog brojnih izveštaja o komercijalnim probioticima niskog kvaliteta koji se prodaju za ljudsku upotrebu, ovaj pregled razmatra metode koje se koriste za testiranje sadržaja probiotičkih mikroorganizama, bezbednost za nameravanu upotrebu i dokazane zdravstvene koristi onih probiotika čiji mikrobiološki kvalitet odstupa od sadržaja koji tvrde proizvođači i održavanja vitalnosti ćelija, tj. stabilnosti probiotika tokom roka trajanja. Pored toga, razmatraju se i neželjeni efekti probiotika i potencijalne opasnosti po zdravlje korisnika.",
publisher = "Belgrade: Pharmaceutical Association of Serbia",
journal = "Arhiv za Farmaciju",
title = "Microbiological Quality of Probiotic Products, Mikrobiološki kvalitet probiotičkih proizvoda",
number = "1",
volume = "73",
doi = "10.5937/arhfarm73-42160",
pages = "17-34"
}

Zavišić, G., Ristić, S., Petković, B., Živkov Šaponja, D., Jojić, N.,& Janković, D.. (2023). Microbiological Quality of Probiotic Products. in Arhiv za Farmaciju
Belgrade: Pharmaceutical Association of Serbia., 73(1), 17-34.
https://doi.org/10.5937/arhfarm73-42160

Zavišić G, Ristić S, Petković B, Živkov Šaponja D, Jojić N, Janković D. Microbiological Quality of Probiotic Products. in Arhiv za Farmaciju. 2023;73(1):17-34.
doi:10.5937/arhfarm73-42160 .

Zavišić, Gordana, Ristić, Slavica, Petković, Branka, Živkov Šaponja, Dragoslava, Jojić, Nikola, Janković, Drina, "Microbiological Quality of Probiotic Products" in Arhiv za Farmaciju, 73, no. 1 (2023):17-34,
https://doi.org/10.5937/arhfarm73-42160 . .

TY  - JOUR
AU  - Zavišić, Gordana
AU  - Ristić, Slavica
AU  - Rikalović, Milena
AU  - Petković, Branka
AU  - Janković, Drina
AU  - Vukadinović, Aleksandar
AU  - Petričević, Saša
PY  - 2022
UR  - https://linkinghub.elsevier.com/retrieve/pii/S1756464622002377
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5091
AB  - The present study aimed to examine the effect of Lactobacillus rhamnosus Rosell 11 and Lactobacillus helveticus Rosell 52 on glucose (blood level and tolerance), lipids (cholesterol and triglycerides), transaminases (AST and ALT), ALP, urea, and creatinine, along with body weight, food intake, liquid consumption, and gross pathology in a mouse model of metabolic syndrome. Male C57BL/6J mice were fed a high-fat high-sucrose diet and treated by oral gavage with a probiotic mixture in three different concentrations (107, 108, and 109 CFU/mL) once daily for 2 months. Probiotic supplementation, particularly at a concentration of 109 CFU, significantly decreased blood glucose and serum triglyceride levels, improved glucose tolerance, and promoted body weight loss in mice fed a high-fat high-sucrose diet. According to the obtained results, probiotic supplementation is useful for controlling glucose and triglyceride levels and could be used as an adjunctive therapeutic approach in patients with metabolic syndrome. © 2022
PB  - Amsterdam: Elsevier
T2  - Journal of Functional Foods
T1  - Beneficial effects of probiotic supplementation on glucose and triglycerides in a mouse model of metabolic syndrome
VL  - 95
DO  - 10.1016/j.jff.2022.105167
SP  - 105167
ER  - 

@article{
author = "Zavišić, Gordana and Ristić, Slavica and Rikalović, Milena and Petković, Branka and Janković, Drina and Vukadinović, Aleksandar and Petričević, Saša",
year = "2022",
abstract = "The present study aimed to examine the effect of Lactobacillus rhamnosus Rosell 11 and Lactobacillus helveticus Rosell 52 on glucose (blood level and tolerance), lipids (cholesterol and triglycerides), transaminases (AST and ALT), ALP, urea, and creatinine, along with body weight, food intake, liquid consumption, and gross pathology in a mouse model of metabolic syndrome. Male C57BL/6J mice were fed a high-fat high-sucrose diet and treated by oral gavage with a probiotic mixture in three different concentrations (107, 108, and 109 CFU/mL) once daily for 2 months. Probiotic supplementation, particularly at a concentration of 109 CFU, significantly decreased blood glucose and serum triglyceride levels, improved glucose tolerance, and promoted body weight loss in mice fed a high-fat high-sucrose diet. According to the obtained results, probiotic supplementation is useful for controlling glucose and triglyceride levels and could be used as an adjunctive therapeutic approach in patients with metabolic syndrome. © 2022",
publisher = "Amsterdam: Elsevier",
journal = "Journal of Functional Foods",
title = "Beneficial effects of probiotic supplementation on glucose and triglycerides in a mouse model of metabolic syndrome",
volume = "95",
doi = "10.1016/j.jff.2022.105167",
pages = "105167"
}

Zavišić, G., Ristić, S., Rikalović, M., Petković, B., Janković, D., Vukadinović, A.,& Petričević, S.. (2022). Beneficial effects of probiotic supplementation on glucose and triglycerides in a mouse model of metabolic syndrome. in Journal of Functional Foods
Amsterdam: Elsevier., 95, 105167.
https://doi.org/10.1016/j.jff.2022.105167

Zavišić G, Ristić S, Rikalović M, Petković B, Janković D, Vukadinović A, Petričević S. Beneficial effects of probiotic supplementation on glucose and triglycerides in a mouse model of metabolic syndrome. in Journal of Functional Foods. 2022;95:105167.
doi:10.1016/j.jff.2022.105167 .

Zavišić, Gordana, Ristić, Slavica, Rikalović, Milena, Petković, Branka, Janković, Drina, Vukadinović, Aleksandar, Petričević, Saša, "Beneficial effects of probiotic supplementation on glucose and triglycerides in a mouse model of metabolic syndrome" in Journal of Functional Foods, 95 (2022):105167,
https://doi.org/10.1016/j.jff.2022.105167 . .

TY  - JOUR
AU  - Petković, Branka
AU  - Kesić, Srđan
AU  - Ristić, Slavica
AU  - Pavković, Željko
AU  - Podgorac, Jelena
AU  - Stojadinović, Gordana
AU  - Pešić, Vesna
PY  - 2020
UR  - https://www.eurekaselect.com/180519/article
UR  - http://www.ncbi.nlm.nih.gov/pubmed/32213154
UR  - https://radar.ibiss.bg.ac.rs/123456789/3879
AB  - BACKGROUND Psychotic states related to psychostimulant misuse in patients with hepatitis C virus infection may complicate acceptance and reaction to antiviral treatment. This observation equally applies to widely used ribavirin therapy. OBJECTIVE We examined psychomotor and body weight gain response to low ribavirin doses after cessation of intermittent amphetamine treatment in adult rats to assess its role in neurobehavioral outcome during psychostimulant withdrawal. METHOD The model of amphetamine-induced (1.5 mg/kg/day, i.p., 7 consecutive days) motor sensitization and affected body weight gain was established in adult male Wistar rats. Then, additional cohort of amphetamine-sensitized rats was subjected to saline (0.9% NaCl; 1 mL/kg/day; i.p.) or ribavirin (10, 20 and 30 mg/kg/day, i.p.) treatment for 7 consecutive days. Animals' motor activity in a novel environment was monitored after the 1st and the 7th saline/ribavirin injection. Body weight gain was calculated as appropriate. Determination and quantification of ribavirin in the brain tissue were performed too. RESULTS The 1st application of ribavirin to amphetamine-sensitized rats affected/decreased their novelty-induced motor activity only at a dose of 30 mg/kg. After the 7th application, ribavirin 30 mg/kg/day still decreased while 10 and 20 mg/kg/day increased novelty-induced motor activity. These behavioral effects coincided with the time required to reach maximum ribavirin concentration in the brain. Body weight gain during withdrawal was not influenced by any of the doses tested. CONCLUSION Ribavirin displays central effects that in repeated treatment, depending on the applied dose, could significantly influence psychomotor response but not body weight gain during psychostimulant/amphetamine withdrawal.
PB  - Bentham Science Publishers Ltd.
T2  - Current Pharmaceutical Design
T1  - A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats
IS  - 31
VL  - 26
DO  - 10.2174/1381612826666200326125821
SP  - 3884
EP  - 3894
ER  - 

@article{
author = "Petković, Branka and Kesić, Srđan and Ristić, Slavica and Pavković, Željko and Podgorac, Jelena and Stojadinović, Gordana and Pešić, Vesna",
year = "2020",
abstract = "BACKGROUND Psychotic states related to psychostimulant misuse in patients with hepatitis C virus infection may complicate acceptance and reaction to antiviral treatment. This observation equally applies to widely used ribavirin therapy. OBJECTIVE We examined psychomotor and body weight gain response to low ribavirin doses after cessation of intermittent amphetamine treatment in adult rats to assess its role in neurobehavioral outcome during psychostimulant withdrawal. METHOD The model of amphetamine-induced (1.5 mg/kg/day, i.p., 7 consecutive days) motor sensitization and affected body weight gain was established in adult male Wistar rats. Then, additional cohort of amphetamine-sensitized rats was subjected to saline (0.9% NaCl; 1 mL/kg/day; i.p.) or ribavirin (10, 20 and 30 mg/kg/day, i.p.) treatment for 7 consecutive days. Animals' motor activity in a novel environment was monitored after the 1st and the 7th saline/ribavirin injection. Body weight gain was calculated as appropriate. Determination and quantification of ribavirin in the brain tissue were performed too. RESULTS The 1st application of ribavirin to amphetamine-sensitized rats affected/decreased their novelty-induced motor activity only at a dose of 30 mg/kg. After the 7th application, ribavirin 30 mg/kg/day still decreased while 10 and 20 mg/kg/day increased novelty-induced motor activity. These behavioral effects coincided with the time required to reach maximum ribavirin concentration in the brain. Body weight gain during withdrawal was not influenced by any of the doses tested. CONCLUSION Ribavirin displays central effects that in repeated treatment, depending on the applied dose, could significantly influence psychomotor response but not body weight gain during psychostimulant/amphetamine withdrawal.",
publisher = "Bentham Science Publishers Ltd.",
journal = "Current Pharmaceutical Design",
title = "A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats",
number = "31",
volume = "26",
doi = "10.2174/1381612826666200326125821",
pages = "3884-3894"
}

Petković, B., Kesić, S., Ristić, S., Pavković, Ž., Podgorac, J., Stojadinović, G.,& Pešić, V.. (2020). A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats. in Current Pharmaceutical Design
Bentham Science Publishers Ltd.., 26(31), 3884-3894.
https://doi.org/10.2174/1381612826666200326125821

Petković B, Kesić S, Ristić S, Pavković Ž, Podgorac J, Stojadinović G, Pešić V. A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats. in Current Pharmaceutical Design. 2020;26(31):3884-3894.
doi:10.2174/1381612826666200326125821 .

Petković, Branka, Kesić, Srđan, Ristić, Slavica, Pavković, Željko, Podgorac, Jelena, Stojadinović, Gordana, Pešić, Vesna, "A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats" in Current Pharmaceutical Design, 26, no. 31 (2020):3884-3894,
https://doi.org/10.2174/1381612826666200326125821 . .

TY  - JOUR
AU  - Petković, Branka
AU  - Kesić, Srđan
AU  - Ristić, Slavica
AU  - Pavković, Željko
AU  - Podgorac, Jelena
AU  - Stojadinović, Gordana
AU  - Pešić, Vesna
PY  - 2020
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3765
AB  - Background: Psychotic states related to psychostimulant misuse in patients with hepatitis C virus infection may complicate acceptance and reaction to antiviral treatment. This observation equally applies to widely used ribavirin therapy.
Objective: We examined psychomotor and body weight gain response to low ribavirin doses after cessation of intermittent amphetamine treatment in adult rats to assess its role in neurobehavioral outcome during psychostimulant withdrawal.
Method: The model of amphetamine-induced (1.5 mg/kg/day, i.p., 7 consecutive days) motor sensitization and affected body weight gain was established in adult male Wistar rats. Then, additional cohort of amphetamine-sensitized rats was subjected to saline (0.9% NaCl; 1 mL/kg/day; i.p.) or ribavirin (10, 20 and 30 mg/kg/day, i.p.) treatment for 7 consecutive days. Animals’ motor activity in a novel environment was monitored after the 1st and the 7th saline/ribavirin injection. Body weight gain was calculated as appropriate. Determination and quantification of ribavirin in the brain tissue were performed too.
Results: The 1st application of ribavirin to amphetamine-sensitized rats affected/decreased their novelty-induced motor activity only at a dose of 30 mg/kg. After the 7th application, ribavirin 30 mg/kg/day still decreased while 10 and 20 mg/kg/day increased novelty-induced motor activity. These behavioral effects coincided with the time required to reach maximum ribavirin concentration in the brain. Body weight gain during withdrawal was not influenced by any of the doses tested.
Conclusion: Ribavirin displays central effects that in repeated treatment, depending on the applied dose, could significantly influence psychomotor response but not body weight gain during psychostimulant/amphetamine withdrawal.
PB  - Bentham Science Publishers Ltd.
T2  - Current Pharmaceutical Design
T1  - A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats
DO  - 10.2174/1381612826666200326125821
ER  - 

@article{
author = "Petković, Branka and Kesić, Srđan and Ristić, Slavica and Pavković, Željko and Podgorac, Jelena and Stojadinović, Gordana and Pešić, Vesna",
year = "2020",
abstract = "Background: Psychotic states related to psychostimulant misuse in patients with hepatitis C virus infection may complicate acceptance and reaction to antiviral treatment. This observation equally applies to widely used ribavirin therapy.
Objective: We examined psychomotor and body weight gain response to low ribavirin doses after cessation of intermittent amphetamine treatment in adult rats to assess its role in neurobehavioral outcome during psychostimulant withdrawal.
Method: The model of amphetamine-induced (1.5 mg/kg/day, i.p., 7 consecutive days) motor sensitization and affected body weight gain was established in adult male Wistar rats. Then, additional cohort of amphetamine-sensitized rats was subjected to saline (0.9% NaCl; 1 mL/kg/day; i.p.) or ribavirin (10, 20 and 30 mg/kg/day, i.p.) treatment for 7 consecutive days. Animals’ motor activity in a novel environment was monitored after the 1st and the 7th saline/ribavirin injection. Body weight gain was calculated as appropriate. Determination and quantification of ribavirin in the brain tissue were performed too.
Results: The 1st application of ribavirin to amphetamine-sensitized rats affected/decreased their novelty-induced motor activity only at a dose of 30 mg/kg. After the 7th application, ribavirin 30 mg/kg/day still decreased while 10 and 20 mg/kg/day increased novelty-induced motor activity. These behavioral effects coincided with the time required to reach maximum ribavirin concentration in the brain. Body weight gain during withdrawal was not influenced by any of the doses tested.
Conclusion: Ribavirin displays central effects that in repeated treatment, depending on the applied dose, could significantly influence psychomotor response but not body weight gain during psychostimulant/amphetamine withdrawal.",
publisher = "Bentham Science Publishers Ltd.",
journal = "Current Pharmaceutical Design",
title = "A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats",
doi = "10.2174/1381612826666200326125821"
}

Petković, B., Kesić, S., Ristić, S., Pavković, Ž., Podgorac, J., Stojadinović, G.,& Pešić, V.. (2020). A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats. in Current Pharmaceutical Design
Bentham Science Publishers Ltd...
https://doi.org/10.2174/1381612826666200326125821

Petković B, Kesić S, Ristić S, Pavković Ž, Podgorac J, Stojadinović G, Pešić V. A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats. in Current Pharmaceutical Design. 2020;.
doi:10.2174/1381612826666200326125821 .

Petković, Branka, Kesić, Srđan, Ristić, Slavica, Pavković, Željko, Podgorac, Jelena, Stojadinović, Gordana, Pešić, Vesna, "A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats" in Current Pharmaceutical Design (2020),
https://doi.org/10.2174/1381612826666200326125821 . .

TY  - JOUR
AU  - Petković, Branka
AU  - Pešić, Vesna
AU  - Veskov, Rosica
AU  - Ristić, Slavica
AU  - Tasić, Jelena
AU  - Piperski, Vesna
AU  - Ruždijić, Sabera
AU  - Jokanović, Milan
AU  - Stukalov, Petar
AU  - Rakić, Ljubiša
PY  - 2004
UR  - https://www.sciencedirect.com/science/article/pii/S0091305704000073?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3804
AB  - The effects of tiazofurin (TR; 2-β-D-ribofuranosylthiazole-4-carboxamide), a purine nucleoside analogue on basal and amphetamine (AMPH)-induced locomotor and stereotypic activity of adult Wistar rat males were studied. The animals were injected with low (3.75, 7.5, and 15 mg/kg ip) and high (62.5, 125, and 250 mg/kg ip) TR doses. Neither low nor high TR doses influenced basal locomotor and stereotypic activity in comparison with the corresponding controls treated with saline only. However, pretreatment with TR at any dose applied, except for the lowest one, significantly decreased AMPH-induced (1.5 mg/kg ip) locomotor activity, while AMPH-induced stereotypic activity was inhibited with the two highest TR doses. In addition, TR was detected in the brain by HPLC already 15 min after the injection (125 mg/kg ip) to reach a maximum 2 h after the administration and was detectable in this tissue during the next 4 h. Our results indicate that TR modifies central regulation of the motor activity, possibly by influencing dopaminergic (DA-ergic) transmission.
PB  - Pergamon-Elsevier Science Ltd
T2  - Pharmacology Biochemistry and Behavior
T1  - The effects of tiazofurin on basal and amphetamine-induced motor activity in rats
IS  - 3
VL  - 77
DO  - 10.1016/j.pbb.2003.12.025
SP  - 575
EP  - 582
ER  - 

@article{
author = "Petković, Branka and Pešić, Vesna and Veskov, Rosica and Ristić, Slavica and Tasić, Jelena and Piperski, Vesna and Ruždijić, Sabera and Jokanović, Milan and Stukalov, Petar and Rakić, Ljubiša",
year = "2004",
abstract = "The effects of tiazofurin (TR; 2-β-D-ribofuranosylthiazole-4-carboxamide), a purine nucleoside analogue on basal and amphetamine (AMPH)-induced locomotor and stereotypic activity of adult Wistar rat males were studied. The animals were injected with low (3.75, 7.5, and 15 mg/kg ip) and high (62.5, 125, and 250 mg/kg ip) TR doses. Neither low nor high TR doses influenced basal locomotor and stereotypic activity in comparison with the corresponding controls treated with saline only. However, pretreatment with TR at any dose applied, except for the lowest one, significantly decreased AMPH-induced (1.5 mg/kg ip) locomotor activity, while AMPH-induced stereotypic activity was inhibited with the two highest TR doses. In addition, TR was detected in the brain by HPLC already 15 min after the injection (125 mg/kg ip) to reach a maximum 2 h after the administration and was detectable in this tissue during the next 4 h. Our results indicate that TR modifies central regulation of the motor activity, possibly by influencing dopaminergic (DA-ergic) transmission.",
publisher = "Pergamon-Elsevier Science Ltd",
journal = "Pharmacology Biochemistry and Behavior",
title = "The effects of tiazofurin on basal and amphetamine-induced motor activity in rats",
number = "3",
volume = "77",
doi = "10.1016/j.pbb.2003.12.025",
pages = "575-582"
}

Petković, B., Pešić, V., Veskov, R., Ristić, S., Tasić, J., Piperski, V., Ruždijić, S., Jokanović, M., Stukalov, P.,& Rakić, L.. (2004). The effects of tiazofurin on basal and amphetamine-induced motor activity in rats. in Pharmacology Biochemistry and Behavior
Pergamon-Elsevier Science Ltd., 77(3), 575-582.
https://doi.org/10.1016/j.pbb.2003.12.025

Petković B, Pešić V, Veskov R, Ristić S, Tasić J, Piperski V, Ruždijić S, Jokanović M, Stukalov P, Rakić L. The effects of tiazofurin on basal and amphetamine-induced motor activity in rats. in Pharmacology Biochemistry and Behavior. 2004;77(3):575-582.
doi:10.1016/j.pbb.2003.12.025 .

Petković, Branka, Pešić, Vesna, Veskov, Rosica, Ristić, Slavica, Tasić, Jelena, Piperski, Vesna, Ruždijić, Sabera, Jokanović, Milan, Stukalov, Petar, Rakić, Ljubiša, "The effects of tiazofurin on basal and amphetamine-induced motor activity in rats" in Pharmacology Biochemistry and Behavior, 77, no. 3 (2004):575-582,
https://doi.org/10.1016/j.pbb.2003.12.025 . .