TY  - CHAP
AU  - Šaponjić, Jasna
AU  - Petrović, Jelena
AU  - Ćirić, Jelena
AU  - Lazić, Katarina
PY  - 2016
UR  - http://dx.doi.org/10.5772/62949
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2474
UR  - http://www.intechopen.com/books/challenges-in-parkinson-s-disease/disorders-of-sleep-and-motor-control-during-the-impaired-cholinergic-innervation-in-rat-relevance-to
AB  - The medical profession has been generally very slow to acknowledge the importance of sleep medicine and sleep research. Disorders of sleep are related to anxiety, many mental and neurodegenerative diseases, cardiovascular and respiratory disorders, and obesity. Our knowledge of the neural substrates of sleep/wake states and sleep-related behavior disorders regulation in health and the diseases, over more than 50 years of sleep research, is based on the experiments in animal models, pharmacotherapy, and the neuropathological studies in humans. But, we still need further work in fundamental multidisciplinary and clinical research between sleep and neurodegenerative disease investigators to understand normal and abnormal sleep, and to provide new insights into preventive or disease-altering approaches for therapy. Our aim is to give an overview of our recent results related to the importance of thalamo-cortical cholinergic brain system in the disorders of sleep and motor control during sleep, with particular relevance to Parkinson’s disease.
PB  - Rijeka: InTech
T2  - Challenges in Parkinson’s Disease
T1  - Disorders of Sleep and Motor Control During the Impaired Cholinergic Innervation in Rat – Relevance to Parkinson’s Disease
DO  - 10.5772/62949
SP  - 136
EP  - 153
ER  - 

@inbook{
author = "Šaponjić, Jasna and Petrović, Jelena and Ćirić, Jelena and Lazić, Katarina",
year = "2016",
abstract = "The medical profession has been generally very slow to acknowledge the importance of sleep medicine and sleep research. Disorders of sleep are related to anxiety, many mental and neurodegenerative diseases, cardiovascular and respiratory disorders, and obesity. Our knowledge of the neural substrates of sleep/wake states and sleep-related behavior disorders regulation in health and the diseases, over more than 50 years of sleep research, is based on the experiments in animal models, pharmacotherapy, and the neuropathological studies in humans. But, we still need further work in fundamental multidisciplinary and clinical research between sleep and neurodegenerative disease investigators to understand normal and abnormal sleep, and to provide new insights into preventive or disease-altering approaches for therapy. Our aim is to give an overview of our recent results related to the importance of thalamo-cortical cholinergic brain system in the disorders of sleep and motor control during sleep, with particular relevance to Parkinson’s disease.",
publisher = "Rijeka: InTech",
journal = "Challenges in Parkinson’s Disease",
booktitle = "Disorders of Sleep and Motor Control During the Impaired Cholinergic Innervation in Rat – Relevance to Parkinson’s Disease",
doi = "10.5772/62949",
pages = "136-153"
}

Šaponjić, J., Petrović, J., Ćirić, J.,& Lazić, K.. (2016). Disorders of Sleep and Motor Control During the Impaired Cholinergic Innervation in Rat – Relevance to Parkinson’s Disease. in Challenges in Parkinson’s Disease
Rijeka: InTech., 136-153.
https://doi.org/10.5772/62949

Šaponjić J, Petrović J, Ćirić J, Lazić K. Disorders of Sleep and Motor Control During the Impaired Cholinergic Innervation in Rat – Relevance to Parkinson’s Disease. in Challenges in Parkinson’s Disease. 2016;:136-153.
doi:10.5772/62949 .

Šaponjić, Jasna, Petrović, Jelena, Ćirić, Jelena, Lazić, Katarina, "Disorders of Sleep and Motor Control During the Impaired Cholinergic Innervation in Rat – Relevance to Parkinson’s Disease" in Challenges in Parkinson’s Disease (2016):136-153,
https://doi.org/10.5772/62949 . .

TY  - JOUR
AU  - Ćirić, Jelena
AU  - Lazić, Katarina
AU  - Petrović, Jelena
AU  - Kalauzi, Aleksandar
AU  - Šaponjić, Jasna
PY  - 2016
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1909
UR  - http://www.sciencedirect.com/science/article/pii/S0166432815303454
AB  - We studied the impact of aging during sleep in the rat models of
   Alzheimer's (AD) and Parkinson's (PD) disease cholinergic neuropathology
   to determine the possible different and earlier onset of age-related
   sleep disorder during the neurodegenerative diseases vs. healthy aging.
   We used the bilateral nucleus basalis (NB) and pedunculopontine
   tegmental nucleus (PPT) lesioned rats as the in vivo models of
   functionally distinct cholinergic neuropathology, and we followed the
   impact of aging on sleep architecture, the electroencephalographic (EEG)
   microstructure and motor control across sleep/wake states.
   Our results have shown for the first time that the earliest signs of
   aging during distinct cholinergic neuropathology were expressed through
   a different and topographically specific EEG microstructure during rapid
   eye movement sleep (REM). EEG delta amplitude attenuation within the
   sensorimotor cortex (SMCx) during REM was the earliest sign of aging in
   the NB lesion. EEG sigma amplitude augmentation within the motor cortex
   (MCx) during REM was the earliest sign of aging in the PPT lesion. In
   addition, aging was differently expressed through the SMCx drive
   alterations, but it was commonly expressed through the MCx drive
   alterations during all sleep/wake states.
   Our study provided evidence of distinct REM sleep disorders and sleep
   state related cortical drives as the signs of aging onset during
   functionally distinct cholinergic neuropathologies (NB lesion vs. PPT
   lesion). (C) 2015 Elsevier B.V. All rights reserved.
T2  - Behavioural Brain Research
T1  - Age-related disorders of sleep and motor control in the rat models of
 functionally distinct cholinergic neuropathology
VL  - 301
DO  - 10.1016/j.bbr.2015.12.046
SP  - 273
EP  - 286
ER  - 

@article{
author = "Ćirić, Jelena and Lazić, Katarina and Petrović, Jelena and Kalauzi, Aleksandar and Šaponjić, Jasna",
year = "2016",
abstract = "We studied the impact of aging during sleep in the rat models of
   Alzheimer's (AD) and Parkinson's (PD) disease cholinergic neuropathology
   to determine the possible different and earlier onset of age-related
   sleep disorder during the neurodegenerative diseases vs. healthy aging.
   We used the bilateral nucleus basalis (NB) and pedunculopontine
   tegmental nucleus (PPT) lesioned rats as the in vivo models of
   functionally distinct cholinergic neuropathology, and we followed the
   impact of aging on sleep architecture, the electroencephalographic (EEG)
   microstructure and motor control across sleep/wake states.
   Our results have shown for the first time that the earliest signs of
   aging during distinct cholinergic neuropathology were expressed through
   a different and topographically specific EEG microstructure during rapid
   eye movement sleep (REM). EEG delta amplitude attenuation within the
   sensorimotor cortex (SMCx) during REM was the earliest sign of aging in
   the NB lesion. EEG sigma amplitude augmentation within the motor cortex
   (MCx) during REM was the earliest sign of aging in the PPT lesion. In
   addition, aging was differently expressed through the SMCx drive
   alterations, but it was commonly expressed through the MCx drive
   alterations during all sleep/wake states.
   Our study provided evidence of distinct REM sleep disorders and sleep
   state related cortical drives as the signs of aging onset during
   functionally distinct cholinergic neuropathologies (NB lesion vs. PPT
   lesion). (C) 2015 Elsevier B.V. All rights reserved.",
journal = "Behavioural Brain Research",
title = "Age-related disorders of sleep and motor control in the rat models of
 functionally distinct cholinergic neuropathology",
volume = "301",
doi = "10.1016/j.bbr.2015.12.046",
pages = "273-286"
}

Ćirić, J., Lazić, K., Petrović, J., Kalauzi, A.,& Šaponjić, J.. (2016). Age-related disorders of sleep and motor control in the rat models of
 functionally distinct cholinergic neuropathology. in Behavioural Brain Research, 301, 273-286.
https://doi.org/10.1016/j.bbr.2015.12.046

Ćirić J, Lazić K, Petrović J, Kalauzi A, Šaponjić J. Age-related disorders of sleep and motor control in the rat models of
 functionally distinct cholinergic neuropathology. in Behavioural Brain Research. 2016;301:273-286.
doi:10.1016/j.bbr.2015.12.046 .

Ćirić, Jelena, Lazić, Katarina, Petrović, Jelena, Kalauzi, Aleksandar, Šaponjić, Jasna, "Age-related disorders of sleep and motor control in the rat models of
 functionally distinct cholinergic neuropathology" in Behavioural Brain Research, 301 (2016):273-286,
https://doi.org/10.1016/j.bbr.2015.12.046 . .

TY  - JOUR
AU  - Šaponjić, Jasna
AU  - Petrović, Jelena
AU  - Kalauzi, Aleksandar
AU  - Ćirić, Jelena
AU  - Lazić, Katarina
AU  - Radulovacki, Miodrag
AU  - Carley, David W
PY  - 2013
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1027
AB  - We examined the effects of unilateral and bilateral nucleus basalis (NB) lesion in rat on sleep/wake states, and sleep/wake state-related electroencephalographic (EEG) frequency relative amplitude distributions. We aimed this study to identify the possible EEG markers for the onset and progression of cortical cholinergic neurodegeneration in rats. NB lesion was performed by ibotenic acid (IBO) microinfusion, and identified by NADPH-diaphorase histochemistry. Sleep/wake states related EEG relative amplitude analysis was done using the Probability Density Estimate (PDE) routine supplied with MATLAB 6.5. Bilateral NB lesion transiently altered gross sleep/wake states topography 14 days following lesion. While control rats exhibited equivalent durations of Wake, NREM and REM, as determined by sensorimotor versus motor cortex EEG, bilateral NB lesion decreased Wake duration in both cortices, with NREM duration increased within sensorimotor cortex, and REM duration increased within motor cortex. Also, Wake, NREM and REM theta relative amplitude was lower in motor versus sensorimotor cortex in all groups of animals. In sensorimotor cortex bilateral NB lesion increased only REM theta relative amplitude from 1421 days following lesion, and returned to control value 28 days following lesion. In motor cortex both Wake and REM theta relative amplitude transiently increased 14 days following unilateral and bilateral NB lesion, and returned to control values 21 days after lesions. We demonstrated at functional level, for the first time, the topographically specific impact of NB cholinergic cortical afferent system dysregulation on sleep/wake states, REM and Wake EEG theta relative amplitude.
T2  - Sleep and Biological Rhythms
T1  - Sleep-state related EEG amplitude distribution in the rat model of cortical cholinergic innervation disorder
IS  - 2
VL  - 11
SP  - 243
EP  - 115
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1027
ER  - 

@article{
author = "Šaponjić, Jasna and Petrović, Jelena and Kalauzi, Aleksandar and Ćirić, Jelena and Lazić, Katarina and Radulovacki, Miodrag and Carley, David W",
year = "2013",
abstract = "We examined the effects of unilateral and bilateral nucleus basalis (NB) lesion in rat on sleep/wake states, and sleep/wake state-related electroencephalographic (EEG) frequency relative amplitude distributions. We aimed this study to identify the possible EEG markers for the onset and progression of cortical cholinergic neurodegeneration in rats. NB lesion was performed by ibotenic acid (IBO) microinfusion, and identified by NADPH-diaphorase histochemistry. Sleep/wake states related EEG relative amplitude analysis was done using the Probability Density Estimate (PDE) routine supplied with MATLAB 6.5. Bilateral NB lesion transiently altered gross sleep/wake states topography 14 days following lesion. While control rats exhibited equivalent durations of Wake, NREM and REM, as determined by sensorimotor versus motor cortex EEG, bilateral NB lesion decreased Wake duration in both cortices, with NREM duration increased within sensorimotor cortex, and REM duration increased within motor cortex. Also, Wake, NREM and REM theta relative amplitude was lower in motor versus sensorimotor cortex in all groups of animals. In sensorimotor cortex bilateral NB lesion increased only REM theta relative amplitude from 1421 days following lesion, and returned to control value 28 days following lesion. In motor cortex both Wake and REM theta relative amplitude transiently increased 14 days following unilateral and bilateral NB lesion, and returned to control values 21 days after lesions. We demonstrated at functional level, for the first time, the topographically specific impact of NB cholinergic cortical afferent system dysregulation on sleep/wake states, REM and Wake EEG theta relative amplitude.",
journal = "Sleep and Biological Rhythms",
title = "Sleep-state related EEG amplitude distribution in the rat model of cortical cholinergic innervation disorder",
number = "2",
volume = "11",
pages = "243-115",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1027"
}

Šaponjić, J., Petrović, J., Kalauzi, A., Ćirić, J., Lazić, K., Radulovacki, M.,& Carley, D. W.. (2013). Sleep-state related EEG amplitude distribution in the rat model of cortical cholinergic innervation disorder. in Sleep and Biological Rhythms, 11(2), 243-115.
https://hdl.handle.net/21.15107/rcub_ibiss_1027

Šaponjić J, Petrović J, Kalauzi A, Ćirić J, Lazić K, Radulovacki M, Carley DW. Sleep-state related EEG amplitude distribution in the rat model of cortical cholinergic innervation disorder. in Sleep and Biological Rhythms. 2013;11(2):243-115.
https://hdl.handle.net/21.15107/rcub_ibiss_1027 .

Šaponjić, Jasna, Petrović, Jelena, Kalauzi, Aleksandar, Ćirić, Jelena, Lazić, Katarina, Radulovacki, Miodrag, Carley, David W, "Sleep-state related EEG amplitude distribution in the rat model of cortical cholinergic innervation disorder" in Sleep and Biological Rhythms, 11, no. 2 (2013):243-115,
https://hdl.handle.net/21.15107/rcub_ibiss_1027 .

TY  - JOUR
AU  - Petrović, Jelena
AU  - Lazić, Katarina
AU  - Ćirić, Jelena
AU  - Kalauzi, Aleksandar
AU  - Šaponjić, Jasna
PY  - 2013
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/949
AB  - In order to identify the differences for the onset and progression of functionally distinct cholinergic innervation disorders, we investigated the effect of bilateral nucleus basalis (NB) and pedunculopontine tegmental nucleus (PPT) lesions on sleep/wake states and electroencephalographic (EEG) microstructure in rats, chronically implanted for sleep recording. Bilateral NB lesion transiently altered Wake/NREM duration within the sensorimotor cortex, and Wake/REM duration within the motor cortex, while there was no change in the sleep/wake states distributions following the bilateral PPT lesion. Bilateral PPT lesion sustainably increased the Wake/REM and REM/Wake transitions followed by inconsistent dysregulation of the NREM/REM and REM/NREM transitions in sensorimotor cortex, but oppositely by their increment throughout four weeks in motor cortex. Bilateral NB lesion sustainably decreased the NREM/REM and REM/NREM transitions during four weeks in the sensorimotor cortex, but oppositely increased them in the motor cortex. We have shown that the sustained beta and gamma augmentation within the sensorimotor and motor cortex, and across all sleep/wake states, simultaneously with Wake delta amplitude attenuation only within the sensorimotor cortex, were the underlying EEG microstructure for the sleep/wake states-transitions structure disturbance following bilateral PPT lesion. In contrast, the bilateral NB lesion only augmented REM theta in sensorimotor cortex during three weeks. We have shown that the NB and PPT lesions induced differing, structure-related EEG microstructure and transition structure disturbances particularly expressed in motor cortex during NREM and REM sleep. We evidenced for the first time the different topographical expression of the functionally distinct cholinergic neuronal innervation impairment in rat. (C) 2013 Elsevier B.V. All rights reserved.
T2  - Behavioural Brain Research
T1  - Topography of the sleep/wake states related EEG microstructure and transitions structure differentiates the functionally distinct cholinergic innervation disorders in rat
IS  - null
VL  - 256
SP  - 41
EP  - 118
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_949
ER  - 

@article{
author = "Petrović, Jelena and Lazić, Katarina and Ćirić, Jelena and Kalauzi, Aleksandar and Šaponjić, Jasna",
year = "2013",
abstract = "In order to identify the differences for the onset and progression of functionally distinct cholinergic innervation disorders, we investigated the effect of bilateral nucleus basalis (NB) and pedunculopontine tegmental nucleus (PPT) lesions on sleep/wake states and electroencephalographic (EEG) microstructure in rats, chronically implanted for sleep recording. Bilateral NB lesion transiently altered Wake/NREM duration within the sensorimotor cortex, and Wake/REM duration within the motor cortex, while there was no change in the sleep/wake states distributions following the bilateral PPT lesion. Bilateral PPT lesion sustainably increased the Wake/REM and REM/Wake transitions followed by inconsistent dysregulation of the NREM/REM and REM/NREM transitions in sensorimotor cortex, but oppositely by their increment throughout four weeks in motor cortex. Bilateral NB lesion sustainably decreased the NREM/REM and REM/NREM transitions during four weeks in the sensorimotor cortex, but oppositely increased them in the motor cortex. We have shown that the sustained beta and gamma augmentation within the sensorimotor and motor cortex, and across all sleep/wake states, simultaneously with Wake delta amplitude attenuation only within the sensorimotor cortex, were the underlying EEG microstructure for the sleep/wake states-transitions structure disturbance following bilateral PPT lesion. In contrast, the bilateral NB lesion only augmented REM theta in sensorimotor cortex during three weeks. We have shown that the NB and PPT lesions induced differing, structure-related EEG microstructure and transition structure disturbances particularly expressed in motor cortex during NREM and REM sleep. We evidenced for the first time the different topographical expression of the functionally distinct cholinergic neuronal innervation impairment in rat. (C) 2013 Elsevier B.V. All rights reserved.",
journal = "Behavioural Brain Research",
title = "Topography of the sleep/wake states related EEG microstructure and transitions structure differentiates the functionally distinct cholinergic innervation disorders in rat",
number = "null",
volume = "256",
pages = "41-118",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_949"
}

Petrović, J., Lazić, K., Ćirić, J., Kalauzi, A.,& Šaponjić, J.. (2013). Topography of the sleep/wake states related EEG microstructure and transitions structure differentiates the functionally distinct cholinergic innervation disorders in rat. in Behavioural Brain Research, 256(null), 41-118.
https://hdl.handle.net/21.15107/rcub_ibiss_949

Petrović J, Lazić K, Ćirić J, Kalauzi A, Šaponjić J. Topography of the sleep/wake states related EEG microstructure and transitions structure differentiates the functionally distinct cholinergic innervation disorders in rat. in Behavioural Brain Research. 2013;256(null):41-118.
https://hdl.handle.net/21.15107/rcub_ibiss_949 .

Petrović, Jelena, Lazić, Katarina, Ćirić, Jelena, Kalauzi, Aleksandar, Šaponjić, Jasna, "Topography of the sleep/wake states related EEG microstructure and transitions structure differentiates the functionally distinct cholinergic innervation disorders in rat" in Behavioural Brain Research, 256, no. null (2013):41-118,
https://hdl.handle.net/21.15107/rcub_ibiss_949 .