TY  - JOUR
AU  - Ignjatović, Đurđica
AU  - Živković, Jelena
AU  - Tovilović-Kovačević, Gordana
AU  - Savikin, Katarina
AU  - Tomić, Mirko
AU  - Maksimović, Zoran
AU  - Jankovic, Teodora
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1973
AB  - Methanol and 70\% acetone extracts from Veronica jacquinii, Veronica
   urticifolia and Veronica teucrium were evaluated regarding their
   neuroprotective/antioxidant effects on the human neuroblastoma SH-SY5Y
   cell line. All extracts exhibited modest protective activity by
   increasing cell survival in cells stressed with sodium nitroprusside
   (9-12\%) and hydrogen peroxide (16-21\%) compared to non-treated cells.
   These activities were accompanied by reductions in the amount of
   superoxide radicals and index of lipid peroxidation. Extracts were
   further analysed for the content of total phenolics, phenylpropanoid
   glycosides and iridoids, and the major compounds acteoside and aucubin.
   The highest amount of total phenolics was observed in V. jacquinii,
   while V. teucrium was richest in total iridoids, acteoside and aucubin.
   Angiogenic properties on EA.hy926 human endothelial cells were also
   examined. At the highest non-toxic concentration (25 mu g/ml), the
   tested extracts inhibited spontaneous tube formation of endothelial
   cells on the extracellular matrix, implying their possible
   antiangiogenic activity. The most potent inhibitory effects were shown
   by methanol extract of V. jacquinii and aqueous acetone extract of V.
   teucrium. The extracts did not significantly change the adhesive or
   migratory capacity of EA.hy926 cells. Considering the traditional use of
   Veronica species, these results suggest a need for further assessment of
   their supposed wound-healing properties.
T2  - Frontiers in Life Science
T1  - Evaluation of angiogenic and neuroprotective potential of different
 extracts from three Veronica species
IS  - 2
VL  - 8
DO  - 10.1080/21553769.2014.998297
SP  - 107
EP  - 116
ER  - 

@article{
author = "Ignjatović, Đurđica and Živković, Jelena and Tovilović-Kovačević, Gordana and Savikin, Katarina and Tomić, Mirko and Maksimović, Zoran and Jankovic, Teodora",
year = "2015",
abstract = "Methanol and 70\% acetone extracts from Veronica jacquinii, Veronica
   urticifolia and Veronica teucrium were evaluated regarding their
   neuroprotective/antioxidant effects on the human neuroblastoma SH-SY5Y
   cell line. All extracts exhibited modest protective activity by
   increasing cell survival in cells stressed with sodium nitroprusside
   (9-12\%) and hydrogen peroxide (16-21\%) compared to non-treated cells.
   These activities were accompanied by reductions in the amount of
   superoxide radicals and index of lipid peroxidation. Extracts were
   further analysed for the content of total phenolics, phenylpropanoid
   glycosides and iridoids, and the major compounds acteoside and aucubin.
   The highest amount of total phenolics was observed in V. jacquinii,
   while V. teucrium was richest in total iridoids, acteoside and aucubin.
   Angiogenic properties on EA.hy926 human endothelial cells were also
   examined. At the highest non-toxic concentration (25 mu g/ml), the
   tested extracts inhibited spontaneous tube formation of endothelial
   cells on the extracellular matrix, implying their possible
   antiangiogenic activity. The most potent inhibitory effects were shown
   by methanol extract of V. jacquinii and aqueous acetone extract of V.
   teucrium. The extracts did not significantly change the adhesive or
   migratory capacity of EA.hy926 cells. Considering the traditional use of
   Veronica species, these results suggest a need for further assessment of
   their supposed wound-healing properties.",
journal = "Frontiers in Life Science",
title = "Evaluation of angiogenic and neuroprotective potential of different
 extracts from three Veronica species",
number = "2",
volume = "8",
doi = "10.1080/21553769.2014.998297",
pages = "107-116"
}

Ignjatović, Đ., Živković, J., Tovilović-Kovačević, G., Savikin, K., Tomić, M., Maksimović, Z.,& Jankovic, T.. (2015). Evaluation of angiogenic and neuroprotective potential of different
 extracts from three Veronica species. in Frontiers in Life Science, 8(2), 107-116.
https://doi.org/10.1080/21553769.2014.998297

Ignjatović Đ, Živković J, Tovilović-Kovačević G, Savikin K, Tomić M, Maksimović Z, Jankovic T. Evaluation of angiogenic and neuroprotective potential of different
 extracts from three Veronica species. in Frontiers in Life Science. 2015;8(2):107-116.
doi:10.1080/21553769.2014.998297 .

Ignjatović, Đurđica, Živković, Jelena, Tovilović-Kovačević, Gordana, Savikin, Katarina, Tomić, Mirko, Maksimović, Zoran, Jankovic, Teodora, "Evaluation of angiogenic and neuroprotective potential of different
 extracts from three Veronica species" in Frontiers in Life Science, 8, no. 2 (2015):107-116,
https://doi.org/10.1080/21553769.2014.998297 . .

TY  - JOUR
AU  - Zivkovic, Jelena
AU  - Barreira, Joao C. M.
AU  - Stojković, Dejan
AU  - Cebovic, Tatjana
AU  - Santos-Buelga, Celestino
AU  - Maksimovic, Zoran
AU  - Ferreira, Isabel C. F. R.
PY  - 2014
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2196
AB  - The phenolic profile and antibacterial, antimutagenic and antitumour
   activities of the methanolic extracts of Veronica urticifolia Jacq. were
   evaluated. HPLC-DAD/ESI-MS analysis revealed the presence of phenolic
   acids, flavonoids and phenylethanoids, with acteoside as the main
   component (14.9 mg/g of extract). Antibacterial effect was determined
   using the microbroth dilution assay and Staphylococcus aureus was the
   most sensitive strain (MIC and MBC = 7.5 mg/mL). Antimutagenic activity
   was evaluated by Ames mutagenicity assay. At 1 mg/plate, the tested
   extract afforded high protection against the mutagenicity of
   nitroquinoline-N-oxide (4NQO) to Salmonella typhimurium strain TA100
   (inhibition rate 48.3\%). Antitumour activity was screened in Ehrlich
   ascites carcinoma (EAC) model. Pretreatment with 2 mg/kg body weight
   showed statistically significant decrease in tumour cell viability,
   while ascites volume and tumour cell count became slightly decreased,
   but not to a statistically significant extent. The results indicate that
   V. urticifolia deserves further research into its potential
   chemoprevention effects. (C) 2014 Elsevier Ltd. All rights reserved.
T2  - Journal of Functional Foods
T1  - Phenolic profile, antibacterial, antimutagenic and antitumour evaluation
 of Veronica urticifolia Jacq.
VL  - 9
DO  - 10.1016/j.jff.2014.04.024
SP  - 192
EP  - 201
ER  - 

@article{
author = "Zivkovic, Jelena and Barreira, Joao C. M. and Stojković, Dejan and Cebovic, Tatjana and Santos-Buelga, Celestino and Maksimovic, Zoran and Ferreira, Isabel C. F. R.",
year = "2014",
abstract = "The phenolic profile and antibacterial, antimutagenic and antitumour
   activities of the methanolic extracts of Veronica urticifolia Jacq. were
   evaluated. HPLC-DAD/ESI-MS analysis revealed the presence of phenolic
   acids, flavonoids and phenylethanoids, with acteoside as the main
   component (14.9 mg/g of extract). Antibacterial effect was determined
   using the microbroth dilution assay and Staphylococcus aureus was the
   most sensitive strain (MIC and MBC = 7.5 mg/mL). Antimutagenic activity
   was evaluated by Ames mutagenicity assay. At 1 mg/plate, the tested
   extract afforded high protection against the mutagenicity of
   nitroquinoline-N-oxide (4NQO) to Salmonella typhimurium strain TA100
   (inhibition rate 48.3\%). Antitumour activity was screened in Ehrlich
   ascites carcinoma (EAC) model. Pretreatment with 2 mg/kg body weight
   showed statistically significant decrease in tumour cell viability,
   while ascites volume and tumour cell count became slightly decreased,
   but not to a statistically significant extent. The results indicate that
   V. urticifolia deserves further research into its potential
   chemoprevention effects. (C) 2014 Elsevier Ltd. All rights reserved.",
journal = "Journal of Functional Foods",
title = "Phenolic profile, antibacterial, antimutagenic and antitumour evaluation
 of Veronica urticifolia Jacq.",
volume = "9",
doi = "10.1016/j.jff.2014.04.024",
pages = "192-201"
}

Zivkovic, J., Barreira, J. C. M., Stojković, D., Cebovic, T., Santos-Buelga, C., Maksimovic, Z.,& Ferreira, I. C. F. R.. (2014). Phenolic profile, antibacterial, antimutagenic and antitumour evaluation
 of Veronica urticifolia Jacq.. in Journal of Functional Foods, 9, 192-201.
https://doi.org/10.1016/j.jff.2014.04.024

Zivkovic J, Barreira JCM, Stojković D, Cebovic T, Santos-Buelga C, Maksimovic Z, Ferreira ICFR. Phenolic profile, antibacterial, antimutagenic and antitumour evaluation
 of Veronica urticifolia Jacq.. in Journal of Functional Foods. 2014;9:192-201.
doi:10.1016/j.jff.2014.04.024 .

Zivkovic, Jelena, Barreira, Joao C. M., Stojković, Dejan, Cebovic, Tatjana, Santos-Buelga, Celestino, Maksimovic, Zoran, Ferreira, Isabel C. F. R., "Phenolic profile, antibacterial, antimutagenic and antitumour evaluation
 of Veronica urticifolia Jacq." in Journal of Functional Foods, 9 (2014):192-201,
https://doi.org/10.1016/j.jff.2014.04.024 . .