TY  - JOUR
AU  - Jagodić, Jovana
AU  - Rovčanin, Branislav
AU  - Borković Mitić, Slavica
AU  - Vujotić, Ljiljana
AU  - Avdin, Viacheslav
AU  - Manojlović, Dragan
AU  - Stojsavljević, Aleksandar
PY  - 2021
UR  - https://doi.org/10.1007/s11356-021-14013-2
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4236
AB  - Studies indicate that the soil, water and consequently foodstuffs in Serbia are significantly poor in zinc (Zn), and thus, it is likely that there is a Zn deficiency in the Serbian population. This study examined the Zn status in multiple clinical samples, including body fluids (serum, cerebrospinal fluid), whole blood and Zn-rich solid tissues (thyroid and brain tissue). Differences between sex and age were also considered, and comparative analysis of Zn status with other world populations was performed. Serum samples from a large number of Serbian adults approximately had twofold lower Zn amounts when compared to other populations. A similar trend was obtained for whole blood. Males had significantly higher amounts of Zn in serum, whole blood and thyroid tissue samples than females. Higher amounts of Zn were observed in the group older than 50 years. Importantly, in thyroid and brain tissues, Zn was 10- and 20-fold lower, respectively, than reported in the literature. Our results indicate that the population in Serbia could be considered Zn deficient. Therefore, adequate oral Zn supplementation and/or foodstuff fortification should be considered to prevent the deleterious effects caused by Zn deficiency.
PB  - Springer Science and Business Media Deutschland GmbH
T2  - Environmental Science and Pollution Research
T1  - Possible zinc deficiency in the Serbian population: examination of body fluids, whole blood and solid tissues
IS  - 34
VL  - 28
DO  - 10.1007/s11356-021-14013-2
SP  - 47439
EP  - 47446
ER  - 

@article{
author = "Jagodić, Jovana and Rovčanin, Branislav and Borković Mitić, Slavica and Vujotić, Ljiljana and Avdin, Viacheslav and Manojlović, Dragan and Stojsavljević, Aleksandar",
year = "2021",
abstract = "Studies indicate that the soil, water and consequently foodstuffs in Serbia are significantly poor in zinc (Zn), and thus, it is likely that there is a Zn deficiency in the Serbian population. This study examined the Zn status in multiple clinical samples, including body fluids (serum, cerebrospinal fluid), whole blood and Zn-rich solid tissues (thyroid and brain tissue). Differences between sex and age were also considered, and comparative analysis of Zn status with other world populations was performed. Serum samples from a large number of Serbian adults approximately had twofold lower Zn amounts when compared to other populations. A similar trend was obtained for whole blood. Males had significantly higher amounts of Zn in serum, whole blood and thyroid tissue samples than females. Higher amounts of Zn were observed in the group older than 50 years. Importantly, in thyroid and brain tissues, Zn was 10- and 20-fold lower, respectively, than reported in the literature. Our results indicate that the population in Serbia could be considered Zn deficient. Therefore, adequate oral Zn supplementation and/or foodstuff fortification should be considered to prevent the deleterious effects caused by Zn deficiency.",
publisher = "Springer Science and Business Media Deutschland GmbH",
journal = "Environmental Science and Pollution Research",
title = "Possible zinc deficiency in the Serbian population: examination of body fluids, whole blood and solid tissues",
number = "34",
volume = "28",
doi = "10.1007/s11356-021-14013-2",
pages = "47439-47446"
}

Jagodić, J., Rovčanin, B., Borković Mitić, S., Vujotić, L., Avdin, V., Manojlović, D.,& Stojsavljević, A.. (2021). Possible zinc deficiency in the Serbian population: examination of body fluids, whole blood and solid tissues. in Environmental Science and Pollution Research
Springer Science and Business Media Deutschland GmbH., 28(34), 47439-47446.
https://doi.org/10.1007/s11356-021-14013-2

Jagodić J, Rovčanin B, Borković Mitić S, Vujotić L, Avdin V, Manojlović D, Stojsavljević A. Possible zinc deficiency in the Serbian population: examination of body fluids, whole blood and solid tissues. in Environmental Science and Pollution Research. 2021;28(34):47439-47446.
doi:10.1007/s11356-021-14013-2 .

Jagodić, Jovana, Rovčanin, Branislav, Borković Mitić, Slavica, Vujotić, Ljiljana, Avdin, Viacheslav, Manojlović, Dragan, Stojsavljević, Aleksandar, "Possible zinc deficiency in the Serbian population: examination of body fluids, whole blood and solid tissues" in Environmental Science and Pollution Research, 28, no. 34 (2021):47439-47446,
https://doi.org/10.1007/s11356-021-14013-2 . .

TY  - JOUR
AU  - Vujotić, Ljiljana
AU  - Matić, Siniša
AU  - Borković Mitić, Slavica
AU  - Stojsavljević, Aleksandar
AU  - Mutić, Jelena
AU  - Baščarević, Vladimir
AU  - Joković, Miloš
AU  - Pavlović, Slađan
PY  - 2020
UR  - https://www.termedia.pl/Association-between-oxidative-stress-biomarkers-and-concentrations-of-some-metal-ions-in-the-blood-of-patients-with-brain-tumors-and-hydrocephalus,19,37458,1,1.html
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3459
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3713
AB  - IntroductionAny substance that induces production of free radicals can be a potential cause of brain damage. The aim of our study was to investigate the relationship between some metal ions and oxidative stress biomarkers in the blood of patients with brain tumor and hydrocephalus.Material and methodsOur study included 27 control subjects, 24 patients with brain tumor and 21 patients with hydrocephalus. The activities of superoxide dismutase (CuZn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), glutathione S-transferase (GST) and acetyl cholinesterase (AChE), as well as concentrations of reduced glutathione (GSH), lipid peroxides (TBARS) and sulfhydryl groups (SH) were analyzed in the plasma and red blood cells (RBCs) of patients. We also determined the concentrations of Mn, Ni, Co, Cu, Zn, As, Se, Cd, Hg and Fe.ResultsThe higher activity of SOD and concentration of GSH in both investigated groups could indicate higher oxidative stress. We also observed decreased levels of SH groups in both groups of patients. In both groups of patients we detected decreased concentrations of Ni, Co, Zn and Fe (and Mn in brain tumor patients) and increased concentrations of As, Se and Cd in the blood. Interestingly, we observed a higher concentration of Cd in both plasma and RBCs of hydrocephalus patients compared to the patients with brain tumor.ConclusionsThere are strong correlations between some metal ion concentrations and certain oxidative stress biomarkers in the blood of patients, which supports our hypothesis, but the observed trend needs to be further investigated.
PB  - Termedia & Banach
T2  - Archives of Medical Science
T1  - Association between oxidative stress biomarkers and concentrations of some metal ions in the blood of patients with brain tumors and hydrocephalus
IS  - 4
VL  - 16
DO  - 10.5114/aoms.2019.87409
SP  - 811
EP  - 819
ER  - 

@article{
author = "Vujotić, Ljiljana and Matić, Siniša and Borković Mitić, Slavica and Stojsavljević, Aleksandar and Mutić, Jelena and Baščarević, Vladimir and Joković, Miloš and Pavlović, Slađan",
year = "2020",
abstract = "IntroductionAny substance that induces production of free radicals can be a potential cause of brain damage. The aim of our study was to investigate the relationship between some metal ions and oxidative stress biomarkers in the blood of patients with brain tumor and hydrocephalus.Material and methodsOur study included 27 control subjects, 24 patients with brain tumor and 21 patients with hydrocephalus. The activities of superoxide dismutase (CuZn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), glutathione S-transferase (GST) and acetyl cholinesterase (AChE), as well as concentrations of reduced glutathione (GSH), lipid peroxides (TBARS) and sulfhydryl groups (SH) were analyzed in the plasma and red blood cells (RBCs) of patients. We also determined the concentrations of Mn, Ni, Co, Cu, Zn, As, Se, Cd, Hg and Fe.ResultsThe higher activity of SOD and concentration of GSH in both investigated groups could indicate higher oxidative stress. We also observed decreased levels of SH groups in both groups of patients. In both groups of patients we detected decreased concentrations of Ni, Co, Zn and Fe (and Mn in brain tumor patients) and increased concentrations of As, Se and Cd in the blood. Interestingly, we observed a higher concentration of Cd in both plasma and RBCs of hydrocephalus patients compared to the patients with brain tumor.ConclusionsThere are strong correlations between some metal ion concentrations and certain oxidative stress biomarkers in the blood of patients, which supports our hypothesis, but the observed trend needs to be further investigated.",
publisher = "Termedia & Banach",
journal = "Archives of Medical Science",
title = "Association between oxidative stress biomarkers and concentrations of some metal ions in the blood of patients with brain tumors and hydrocephalus",
number = "4",
volume = "16",
doi = "10.5114/aoms.2019.87409",
pages = "811-819"
}

Vujotić, L., Matić, S., Borković Mitić, S., Stojsavljević, A., Mutić, J., Baščarević, V., Joković, M.,& Pavlović, S.. (2020). Association between oxidative stress biomarkers and concentrations of some metal ions in the blood of patients with brain tumors and hydrocephalus. in Archives of Medical Science
Termedia & Banach., 16(4), 811-819.
https://doi.org/10.5114/aoms.2019.87409

Vujotić L, Matić S, Borković Mitić S, Stojsavljević A, Mutić J, Baščarević V, Joković M, Pavlović S. Association between oxidative stress biomarkers and concentrations of some metal ions in the blood of patients with brain tumors and hydrocephalus. in Archives of Medical Science. 2020;16(4):811-819.
doi:10.5114/aoms.2019.87409 .

Vujotić, Ljiljana, Matić, Siniša, Borković Mitić, Slavica, Stojsavljević, Aleksandar, Mutić, Jelena, Baščarević, Vladimir, Joković, Miloš, Pavlović, Slađan, "Association between oxidative stress biomarkers and concentrations of some metal ions in the blood of patients with brain tumors and hydrocephalus" in Archives of Medical Science, 16, no. 4 (2020):811-819,
https://doi.org/10.5114/aoms.2019.87409 . .

TY  - JOUR
AU  - Stojsavljević, Aleksandar
AU  - Jagodić, Jovana
AU  - Vujotić, Ljiljana
AU  - Borković Mitić, Slavica
AU  - Rašić-Milutinović, Zorica
AU  - Jovanović, Dragana
AU  - Gavrović-Jankulović, Marija
AU  - Manojlović, Dragan
PY  - 2020
UR  - http://link.springer.com/10.1007/s11356-019-06936-8
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3530
AB  - This study was aimed to determine reference values (RVs) for the manganese (Mn), copper (Cu), zinc (Zn), and selenium (Se) in the whole blood (B) and serum (S) samples of the Serbian population. Blood specimens were collected from healthy persons (n = 295; women/men ratio = 149/146; mean age: 42 ± 2 years). The RVs were calculated as lower limit (LL) and upper limit (UL) of the 95% confidence interval (CI) and were expressed as percentiles (P) in the range from P2.5 to P97.5. The influences of sex, age, and smoking habits on element profiles were considered. It was found that the contents of B-Cu and S-Cu were higher in women, while the contents of B-Zn and S-Zn were higher in men. Both trace elements were significantly increased in a group of persons above 40 when compared to a younger persons (≤ 40 years). According to smoking habits, increased content was found only for S-Mn in the nonsmoker's group (p < 0.05). Comparing our results to the results reported in other population groups worldwide, the Serbian population had significantly reduced content of Se in both types of samples. This finding could highlight the deficiency of Se in the investigated Serbian population and could contribute to the better understanding of the molecular basis for the increased incidence of thyroid and other diseases in which selenium plays a key role.
T2  - Environmental Science and Pollution Research
T1  - Reference values for trace essential elements in the whole blood and serum samples of the adult Serbian population: significance of selenium deficiency.
IS  - 2
VL  - 27
DO  - 10.1007/s11356-019-06936-8
SP  - 1397
EP  - 1405
ER  - 

@article{
author = "Stojsavljević, Aleksandar and Jagodić, Jovana and Vujotić, Ljiljana and Borković Mitić, Slavica and Rašić-Milutinović, Zorica and Jovanović, Dragana and Gavrović-Jankulović, Marija and Manojlović, Dragan",
year = "2020",
abstract = "This study was aimed to determine reference values (RVs) for the manganese (Mn), copper (Cu), zinc (Zn), and selenium (Se) in the whole blood (B) and serum (S) samples of the Serbian population. Blood specimens were collected from healthy persons (n = 295; women/men ratio = 149/146; mean age: 42 ± 2 years). The RVs were calculated as lower limit (LL) and upper limit (UL) of the 95% confidence interval (CI) and were expressed as percentiles (P) in the range from P2.5 to P97.5. The influences of sex, age, and smoking habits on element profiles were considered. It was found that the contents of B-Cu and S-Cu were higher in women, while the contents of B-Zn and S-Zn were higher in men. Both trace elements were significantly increased in a group of persons above 40 when compared to a younger persons (≤ 40 years). According to smoking habits, increased content was found only for S-Mn in the nonsmoker's group (p < 0.05). Comparing our results to the results reported in other population groups worldwide, the Serbian population had significantly reduced content of Se in both types of samples. This finding could highlight the deficiency of Se in the investigated Serbian population and could contribute to the better understanding of the molecular basis for the increased incidence of thyroid and other diseases in which selenium plays a key role.",
journal = "Environmental Science and Pollution Research",
title = "Reference values for trace essential elements in the whole blood and serum samples of the adult Serbian population: significance of selenium deficiency.",
number = "2",
volume = "27",
doi = "10.1007/s11356-019-06936-8",
pages = "1397-1405"
}

Stojsavljević, A., Jagodić, J., Vujotić, L., Borković Mitić, S., Rašić-Milutinović, Z., Jovanović, D., Gavrović-Jankulović, M.,& Manojlović, D.. (2020). Reference values for trace essential elements in the whole blood and serum samples of the adult Serbian population: significance of selenium deficiency.. in Environmental Science and Pollution Research, 27(2), 1397-1405.
https://doi.org/10.1007/s11356-019-06936-8

Stojsavljević A, Jagodić J, Vujotić L, Borković Mitić S, Rašić-Milutinović Z, Jovanović D, Gavrović-Jankulović M, Manojlović D. Reference values for trace essential elements in the whole blood and serum samples of the adult Serbian population: significance of selenium deficiency.. in Environmental Science and Pollution Research. 2020;27(2):1397-1405.
doi:10.1007/s11356-019-06936-8 .

Stojsavljević, Aleksandar, Jagodić, Jovana, Vujotić, Ljiljana, Borković Mitić, Slavica, Rašić-Milutinović, Zorica, Jovanović, Dragana, Gavrović-Jankulović, Marija, Manojlović, Dragan, "Reference values for trace essential elements in the whole blood and serum samples of the adult Serbian population: significance of selenium deficiency." in Environmental Science and Pollution Research, 27, no. 2 (2020):1397-1405,
https://doi.org/10.1007/s11356-019-06936-8 . .

TY  - JOUR
AU  - Stojsavljević, Aleksandar
AU  - Vujotić, Ljiljana
AU  - Rovčanin, Branislav
AU  - Borković Mitić, Slavica
AU  - Gavrović-Jankulović, Marija
AU  - Manojlović, Dragan
PY  - 2020
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3624
AB  - The pathogenesis of malignant brain tumors (MBTs) should be better understood due to the evident association between prolonged exposure to metals and increased risk of MBTs. The present research aimed to find trace metals that could contribute to the pathogenesis of MBTs. Essential trace elements (Mn, Co, Zn, Cu, Se) and relevant toxic metals (Al, Ni, As, Sr, Cd, Ce, Pt, Pb, U) in the serum, cell fraction (CF), cerebrospinal fluid (CSF) and cancerous tissue (CT) samples of MBT patients were analyzed. The results were compared with sex- and age-matched control groups. For the first time, this research showed that elemental profiles of serum, CF, CSF and CT samples in MBT patients were significantly altered compared to the appropriate controls, as well as that higher contents of trace elements (particularly Mn, Se, and Pb) could be involved in the pathogenesis of MBTs. However, the most noticeable change found was the elevated U content, indicating its considerable role as a major cerebral discriminator of the presence/absence of MBTs. The U/Se ratio could be considered as an appropriate blood marker in diagnostic MBT evaluation. The reported results could contribute to better understanding of the poorly understood pathogenesis of MBTs. Furthermore, the reported results could highlight a molecular basis for the pathophysiological changes caused by the hazardous effects of trace metals on brain homeostasis.
T2  - Scientific Reports
T1  - Assessment of trace metal alterations in the blood, cerebrospinal fluid and tissue samples of patients with malignant brain tumors
IS  - 1
VL  - 10
DO  - 10.1038/s41598-020-60774-0
SP  - 3816
ER  - 

@article{
author = "Stojsavljević, Aleksandar and Vujotić, Ljiljana and Rovčanin, Branislav and Borković Mitić, Slavica and Gavrović-Jankulović, Marija and Manojlović, Dragan",
year = "2020",
abstract = "The pathogenesis of malignant brain tumors (MBTs) should be better understood due to the evident association between prolonged exposure to metals and increased risk of MBTs. The present research aimed to find trace metals that could contribute to the pathogenesis of MBTs. Essential trace elements (Mn, Co, Zn, Cu, Se) and relevant toxic metals (Al, Ni, As, Sr, Cd, Ce, Pt, Pb, U) in the serum, cell fraction (CF), cerebrospinal fluid (CSF) and cancerous tissue (CT) samples of MBT patients were analyzed. The results were compared with sex- and age-matched control groups. For the first time, this research showed that elemental profiles of serum, CF, CSF and CT samples in MBT patients were significantly altered compared to the appropriate controls, as well as that higher contents of trace elements (particularly Mn, Se, and Pb) could be involved in the pathogenesis of MBTs. However, the most noticeable change found was the elevated U content, indicating its considerable role as a major cerebral discriminator of the presence/absence of MBTs. The U/Se ratio could be considered as an appropriate blood marker in diagnostic MBT evaluation. The reported results could contribute to better understanding of the poorly understood pathogenesis of MBTs. Furthermore, the reported results could highlight a molecular basis for the pathophysiological changes caused by the hazardous effects of trace metals on brain homeostasis.",
journal = "Scientific Reports",
title = "Assessment of trace metal alterations in the blood, cerebrospinal fluid and tissue samples of patients with malignant brain tumors",
number = "1",
volume = "10",
doi = "10.1038/s41598-020-60774-0",
pages = "3816"
}

Stojsavljević, A., Vujotić, L., Rovčanin, B., Borković Mitić, S., Gavrović-Jankulović, M.,& Manojlović, D.. (2020). Assessment of trace metal alterations in the blood, cerebrospinal fluid and tissue samples of patients with malignant brain tumors. in Scientific Reports, 10(1), 3816.
https://doi.org/10.1038/s41598-020-60774-0

Stojsavljević A, Vujotić L, Rovčanin B, Borković Mitić S, Gavrović-Jankulović M, Manojlović D. Assessment of trace metal alterations in the blood, cerebrospinal fluid and tissue samples of patients with malignant brain tumors. in Scientific Reports. 2020;10(1):3816.
doi:10.1038/s41598-020-60774-0 .

Stojsavljević, Aleksandar, Vujotić, Ljiljana, Rovčanin, Branislav, Borković Mitić, Slavica, Gavrović-Jankulović, Marija, Manojlović, Dragan, "Assessment of trace metal alterations in the blood, cerebrospinal fluid and tissue samples of patients with malignant brain tumors" in Scientific Reports, 10, no. 1 (2020):3816,
https://doi.org/10.1038/s41598-020-60774-0 . .

TY  - JOUR
AU  - Vujotić, Ljiljana
AU  - Matić, Siniša
AU  - Borković Mitić, Slavica
AU  - Stojsavljević, Aleksandar
AU  - Mutić, Jelena
AU  - Baščarević, Vladimir
AU  - Joković, Miloš
AU  - Pavlović, Slađan
PY  - 2019
UR  - https://www.termedia.pl/Association-between-oxidative-stress-biomarkers-and-concentrations-of-some-metal-ions-in-the-blood-of-patients-with-brain-tumors-and-hydrocephalus,19,37458,1,1.html
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3459
AB  - Introduction
Any substance that induces production of free radicals can be a potential cause of brain damage. The aim of our study was to investigate the relationship between some metal ions and oxidative stress biomarkers in the blood of patients with brain tumor and hydrocephalus.

Material and methods
Our study included 27 control subjects, 24 patients with brain tumor and 21 patients with hydrocephalus. The activities of superoxide dismutase (CuZn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), glutathione S-transferase (GST) and acetyl cholinesterase (AChE), as well as concentrations of reduced glutathione (GSH), lipid peroxides (TBARS) and sulfhydryl groups (SH) were analyzed in the plasma and red blood cells (RBCs) of patients. We also determined the concentrations of Mn, Ni, Co, Cu, Zn, As, Se, Cd, Hg and Fe.

Results
The higher activity of SOD and concentration of GSH in both investigated groups could indicate higher oxidative stress. We also observed decreased levels of SH groups in both groups of patients. In both groups of patients we detected decreased concentrations of Ni, Co, Zn and Fe (and Mn in brain tumor patients) and increased concentrations of As, Se and Cd in the blood. Interestingly, we observed a higher concentration of Cd in both plasma and RBCs of hydrocephalus patients compared to the patients with brain tumor.

Conclusions
There are strong correlations between some metal ion concentrations and certain oxidative stress biomarkers in the blood of patients, which supports our hypothesis, but the observed trend needs to be further investigated.
PB  - Termedia & Banach
T2  - Archives of Medical Science
T1  - Association between oxidative stress biomarkers and concentrations of some metal ions in the blood of patients with brain tumors and hydrocephalus
DO  - 10.5114/aoms.2019.87409
ER  - 

@article{
author = "Vujotić, Ljiljana and Matić, Siniša and Borković Mitić, Slavica and Stojsavljević, Aleksandar and Mutić, Jelena and Baščarević, Vladimir and Joković, Miloš and Pavlović, Slađan",
year = "2019",
abstract = "Introduction
Any substance that induces production of free radicals can be a potential cause of brain damage. The aim of our study was to investigate the relationship between some metal ions and oxidative stress biomarkers in the blood of patients with brain tumor and hydrocephalus.

Material and methods
Our study included 27 control subjects, 24 patients with brain tumor and 21 patients with hydrocephalus. The activities of superoxide dismutase (CuZn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), glutathione S-transferase (GST) and acetyl cholinesterase (AChE), as well as concentrations of reduced glutathione (GSH), lipid peroxides (TBARS) and sulfhydryl groups (SH) were analyzed in the plasma and red blood cells (RBCs) of patients. We also determined the concentrations of Mn, Ni, Co, Cu, Zn, As, Se, Cd, Hg and Fe.

Results
The higher activity of SOD and concentration of GSH in both investigated groups could indicate higher oxidative stress. We also observed decreased levels of SH groups in both groups of patients. In both groups of patients we detected decreased concentrations of Ni, Co, Zn and Fe (and Mn in brain tumor patients) and increased concentrations of As, Se and Cd in the blood. Interestingly, we observed a higher concentration of Cd in both plasma and RBCs of hydrocephalus patients compared to the patients with brain tumor.

Conclusions
There are strong correlations between some metal ion concentrations and certain oxidative stress biomarkers in the blood of patients, which supports our hypothesis, but the observed trend needs to be further investigated.",
publisher = "Termedia & Banach",
journal = "Archives of Medical Science",
title = "Association between oxidative stress biomarkers and concentrations of some metal ions in the blood of patients with brain tumors and hydrocephalus",
doi = "10.5114/aoms.2019.87409"
}

Vujotić, L., Matić, S., Borković Mitić, S., Stojsavljević, A., Mutić, J., Baščarević, V., Joković, M.,& Pavlović, S.. (2019). Association between oxidative stress biomarkers and concentrations of some metal ions in the blood of patients with brain tumors and hydrocephalus. in Archives of Medical Science
Termedia & Banach..
https://doi.org/10.5114/aoms.2019.87409

Vujotić L, Matić S, Borković Mitić S, Stojsavljević A, Mutić J, Baščarević V, Joković M, Pavlović S. Association between oxidative stress biomarkers and concentrations of some metal ions in the blood of patients with brain tumors and hydrocephalus. in Archives of Medical Science. 2019;.
doi:10.5114/aoms.2019.87409 .

Vujotić, Ljiljana, Matić, Siniša, Borković Mitić, Slavica, Stojsavljević, Aleksandar, Mutić, Jelena, Baščarević, Vladimir, Joković, Miloš, Pavlović, Slađan, "Association between oxidative stress biomarkers and concentrations of some metal ions in the blood of patients with brain tumors and hydrocephalus" in Archives of Medical Science (2019),
https://doi.org/10.5114/aoms.2019.87409 . .

TY  - JOUR
AU  - Stojsavljević, Aleksandar
AU  - Borković Mitić, Slavica
AU  - Vujotić, Ljiljana
AU  - Grujičić, Danica
AU  - Gavrović-Jankulović, Marija
AU  - Manojlović, Dragan
PY  - 2018
UR  - https://www.sciencedirect.com/science/article/pii/S0147651318311783?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3192
AB  - The purpose of this study was to establish reference values (RVs) for the occupationally- and environmentally-important toxic elements in the whole blood of adult Serbian population for the first time. Contaminated drinking water with arsenic, high share of smokers in the country, removing tetraethyl lead from the gasoline and war attack at the end of the twentieth century were some of the reasons to provide background information for arsenic (As), cadmium (Cd), lead (Pb), thorium (Th), and uranium (U) in the blood of the Serbian population. The whole blood samples were collected from the healthy respondents living in the Belgrade and surrounding areas of the capital (n = 305; w/m ratio = 154/151; mean age: 41 ± 2). The concentrations of toxic metals were determined by inductively coupled plasma-mass spectrometry (ICP-MS). Reference values were estimated as the lower limit (LL) and upper limit (UL) of the 95% confidence interval (CI), together with the selected percentiles (P2.5-P97.5). The obtained geometric mean (GM) for As, Cd, Pb, Th, and U were: 0.50 ng/g, 0.32 ng/g, 20.94 ng/g, 0.30 ng/g, and 0.06 ng/g, respectively. The influences of age, sex and lifestyle on results were considered. Women have significantly higher levels of Cd and Th than men. The increased level of Th was observed in the aged group below 40 years, while smokers had significantly higher levels of Pb and double higher level of Cd in the blood than non-smokers (p < 0.05). In comparison with other population groups worldwide, the Serbian population had significantly higher levels of Th and U (up to 100 times higher). These findings could contribute to better understanding of the molecular basis for the development of various health hazards, including the increased incidence of cancer among the Serbian population which need be confirmed by clinical studies.
T2  - Ecotoxicology and Environmental Safety
T1  - The human biomonitoring study in Serbia: Background levels for arsenic, cadmium, lead, thorium and uranium in the whole blood of adult Serbian population.
VL  - 169
DO  - 10.1016/j.ecoenv.2018.11.043
SP  - 402
EP  - 409
ER  - 

@article{
author = "Stojsavljević, Aleksandar and Borković Mitić, Slavica and Vujotić, Ljiljana and Grujičić, Danica and Gavrović-Jankulović, Marija and Manojlović, Dragan",
year = "2018",
abstract = "The purpose of this study was to establish reference values (RVs) for the occupationally- and environmentally-important toxic elements in the whole blood of adult Serbian population for the first time. Contaminated drinking water with arsenic, high share of smokers in the country, removing tetraethyl lead from the gasoline and war attack at the end of the twentieth century were some of the reasons to provide background information for arsenic (As), cadmium (Cd), lead (Pb), thorium (Th), and uranium (U) in the blood of the Serbian population. The whole blood samples were collected from the healthy respondents living in the Belgrade and surrounding areas of the capital (n = 305; w/m ratio = 154/151; mean age: 41 ± 2). The concentrations of toxic metals were determined by inductively coupled plasma-mass spectrometry (ICP-MS). Reference values were estimated as the lower limit (LL) and upper limit (UL) of the 95% confidence interval (CI), together with the selected percentiles (P2.5-P97.5). The obtained geometric mean (GM) for As, Cd, Pb, Th, and U were: 0.50 ng/g, 0.32 ng/g, 20.94 ng/g, 0.30 ng/g, and 0.06 ng/g, respectively. The influences of age, sex and lifestyle on results were considered. Women have significantly higher levels of Cd and Th than men. The increased level of Th was observed in the aged group below 40 years, while smokers had significantly higher levels of Pb and double higher level of Cd in the blood than non-smokers (p < 0.05). In comparison with other population groups worldwide, the Serbian population had significantly higher levels of Th and U (up to 100 times higher). These findings could contribute to better understanding of the molecular basis for the development of various health hazards, including the increased incidence of cancer among the Serbian population which need be confirmed by clinical studies.",
journal = "Ecotoxicology and Environmental Safety",
title = "The human biomonitoring study in Serbia: Background levels for arsenic, cadmium, lead, thorium and uranium in the whole blood of adult Serbian population.",
volume = "169",
doi = "10.1016/j.ecoenv.2018.11.043",
pages = "402-409"
}

Stojsavljević, A., Borković Mitić, S., Vujotić, L., Grujičić, D., Gavrović-Jankulović, M.,& Manojlović, D.. (2018). The human biomonitoring study in Serbia: Background levels for arsenic, cadmium, lead, thorium and uranium in the whole blood of adult Serbian population.. in Ecotoxicology and Environmental Safety, 169, 402-409.
https://doi.org/10.1016/j.ecoenv.2018.11.043

Stojsavljević A, Borković Mitić S, Vujotić L, Grujičić D, Gavrović-Jankulović M, Manojlović D. The human biomonitoring study in Serbia: Background levels for arsenic, cadmium, lead, thorium and uranium in the whole blood of adult Serbian population.. in Ecotoxicology and Environmental Safety. 2018;169:402-409.
doi:10.1016/j.ecoenv.2018.11.043 .

Stojsavljević, Aleksandar, Borković Mitić, Slavica, Vujotić, Ljiljana, Grujičić, Danica, Gavrović-Jankulović, Marija, Manojlović, Dragan, "The human biomonitoring study in Serbia: Background levels for arsenic, cadmium, lead, thorium and uranium in the whole blood of adult Serbian population." in Ecotoxicology and Environmental Safety, 169 (2018):402-409,
https://doi.org/10.1016/j.ecoenv.2018.11.043 . .