TY  - JOUR
AU  - Radić, I
AU  - Mijović, M
AU  - Tatalović, Nikola
AU  - Mitić, M
AU  - Lukić, V
AU  - Joksimović, B
AU  - Petrović, Z
AU  - Ristić, S
AU  - Veličković, S
AU  - Nestorovic, V
AU  - Corac, A
AU  - Mirić, M
AU  - Adžić, M
AU  - Blagojević, Duško
AU  - Popović, L
AU  - Hudomal, S J
PY  - 2019
UR  - http://journals.sagepub.com/doi/10.1177/0960327119829518
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3281
AB  - In 2012, alcohol liver disease resulted in 3.3 million-5.9% of global deaths. This study introduced whey protection capacity against chronic alcohol-induced liver injury. Rats were orally administered to 12% ethanol solution in water (ad libitum, average 8.14 g of ethanol/kg body weight (b.w.)/day) alone or combined with whey ( per os, 2 g/kg b.w./day). After 6-week treatment, chronic ethanol consumption induced significant histopathological liver changes: congestion, central vein dilation, hepatic portal vein branch dilation, Kupffer cells hyperplasia, fatty liver changes, and hepatocytes focal necrosis. Ethanol significantly increased liver catalase activity and glutathione reductase protein expression without significant effects on antioxidative enzymes: glutathione peroxidase (GPx), copper-zinc-containing superoxide dismutase (CuZnSOD) and manganese-containing superoxide dismutase (MnSOD). Co-treatment with whey significantly attenuated pathohistological changes induced by ethanol ingestion and increased GSH-Px and nuclear factor kappa B (NF-κB) protein expression. Our results showed positive effects of whey on liver chronically exposed to ethanol, which seem to be associated with NF-κB-GPx signaling.
T2  - Human & Experimental Toxicology
T1  - Protective effects of whey on rat liver damage induced by chronic alcohol intake.
DO  - 10.1177/0960327119829518
ER  - 

@article{
author = "Radić, I and Mijović, M and Tatalović, Nikola and Mitić, M and Lukić, V and Joksimović, B and Petrović, Z and Ristić, S and Veličković, S and Nestorovic, V and Corac, A and Mirić, M and Adžić, M and Blagojević, Duško and Popović, L and Hudomal, S J",
year = "2019",
abstract = "In 2012, alcohol liver disease resulted in 3.3 million-5.9% of global deaths. This study introduced whey protection capacity against chronic alcohol-induced liver injury. Rats were orally administered to 12% ethanol solution in water (ad libitum, average 8.14 g of ethanol/kg body weight (b.w.)/day) alone or combined with whey ( per os, 2 g/kg b.w./day). After 6-week treatment, chronic ethanol consumption induced significant histopathological liver changes: congestion, central vein dilation, hepatic portal vein branch dilation, Kupffer cells hyperplasia, fatty liver changes, and hepatocytes focal necrosis. Ethanol significantly increased liver catalase activity and glutathione reductase protein expression without significant effects on antioxidative enzymes: glutathione peroxidase (GPx), copper-zinc-containing superoxide dismutase (CuZnSOD) and manganese-containing superoxide dismutase (MnSOD). Co-treatment with whey significantly attenuated pathohistological changes induced by ethanol ingestion and increased GSH-Px and nuclear factor kappa B (NF-κB) protein expression. Our results showed positive effects of whey on liver chronically exposed to ethanol, which seem to be associated with NF-κB-GPx signaling.",
journal = "Human & Experimental Toxicology",
title = "Protective effects of whey on rat liver damage induced by chronic alcohol intake.",
doi = "10.1177/0960327119829518"
}

Radić, I., Mijović, M., Tatalović, N., Mitić, M., Lukić, V., Joksimović, B., Petrović, Z., Ristić, S., Veličković, S., Nestorovic, V., Corac, A., Mirić, M., Adžić, M., Blagojević, D., Popović, L.,& Hudomal, S. J.. (2019). Protective effects of whey on rat liver damage induced by chronic alcohol intake.. in Human & Experimental Toxicology.
https://doi.org/10.1177/0960327119829518

Radić I, Mijović M, Tatalović N, Mitić M, Lukić V, Joksimović B, Petrović Z, Ristić S, Veličković S, Nestorovic V, Corac A, Mirić M, Adžić M, Blagojević D, Popović L, Hudomal SJ. Protective effects of whey on rat liver damage induced by chronic alcohol intake.. in Human & Experimental Toxicology. 2019;.
doi:10.1177/0960327119829518 .

Radić, I, Mijović, M, Tatalović, Nikola, Mitić, M, Lukić, V, Joksimović, B, Petrović, Z, Ristić, S, Veličković, S, Nestorovic, V, Corac, A, Mirić, M, Adžić, M, Blagojević, Duško, Popović, L, Hudomal, S J, "Protective effects of whey on rat liver damage induced by chronic alcohol intake." in Human & Experimental Toxicology (2019),
https://doi.org/10.1177/0960327119829518 . .

TY  - JOUR
AU  - Velkovski, Sasko D
AU  - Ristić, S
AU  - Milošević, Verica
AU  - Pavlović, Slađan
AU  - Saičić, Zorica
AU  - Starčević, Vesna P.
PY  - 2002
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1807
AB  - In this study we measured the effects of eight-week atherogenic diet on plasma lipid status, glutathione-S-transferase activity, red blood cells-catalase activity, and glutathione and vitamin E plasma level adult male Wistar albino rats. The animals were sacrificed by decapitation 24 h after the end of the diet. Triglycerides, total cholesterol, and LDL cholesterol plasma levels, as well as LDL/HDL ratio, and vitamin E plasma level significantly raised (p<0,05) after the diet in comparison with the controls. HDL cholesterol plasma level, glutathione-S-transferase and red blood cells-catalase activities, and glutathione plasma level remained unchanged (p>0,05). These findings demonstrated that prolonged specific atherogenic diet in rats induced significant raise of the lipid parameters, but did not affect blood antioxidant status.
T2  - Jugoslovenska Medicinska Biohemija-Yugoslav Medical Biochemistry
T1  - Effects of prolonged atherogenic diet on lipid status and some antioxidant parameters in rat blood
IS  - 1
VL  - 21
EP  - 35
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1807
ER  - 

@article{
author = "Velkovski, Sasko D and Ristić, S and Milošević, Verica and Pavlović, Slađan and Saičić, Zorica and Starčević, Vesna P.",
year = "2002",
abstract = "In this study we measured the effects of eight-week atherogenic diet on plasma lipid status, glutathione-S-transferase activity, red blood cells-catalase activity, and glutathione and vitamin E plasma level adult male Wistar albino rats. The animals were sacrificed by decapitation 24 h after the end of the diet. Triglycerides, total cholesterol, and LDL cholesterol plasma levels, as well as LDL/HDL ratio, and vitamin E plasma level significantly raised (p<0,05) after the diet in comparison with the controls. HDL cholesterol plasma level, glutathione-S-transferase and red blood cells-catalase activities, and glutathione plasma level remained unchanged (p>0,05). These findings demonstrated that prolonged specific atherogenic diet in rats induced significant raise of the lipid parameters, but did not affect blood antioxidant status.",
journal = "Jugoslovenska Medicinska Biohemija-Yugoslav Medical Biochemistry",
title = "Effects of prolonged atherogenic diet on lipid status and some antioxidant parameters in rat blood",
number = "1",
volume = "21",
pages = "35",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1807"
}

Velkovski, S. D., Ristić, S., Milošević, V., Pavlović, S., Saičić, Z.,& Starčević, V. P.. (2002). Effects of prolonged atherogenic diet on lipid status and some antioxidant parameters in rat blood. in Jugoslovenska Medicinska Biohemija-Yugoslav Medical Biochemistry, 21(1).
https://hdl.handle.net/21.15107/rcub_ibiss_1807

Velkovski SD, Ristić S, Milošević V, Pavlović S, Saičić Z, Starčević VP. Effects of prolonged atherogenic diet on lipid status and some antioxidant parameters in rat blood. in Jugoslovenska Medicinska Biohemija-Yugoslav Medical Biochemistry. 2002;21(1):null-35.
https://hdl.handle.net/21.15107/rcub_ibiss_1807 .

Velkovski, Sasko D, Ristić, S, Milošević, Verica, Pavlović, Slađan, Saičić, Zorica, Starčević, Vesna P., "Effects of prolonged atherogenic diet on lipid status and some antioxidant parameters in rat blood" in Jugoslovenska Medicinska Biohemija-Yugoslav Medical Biochemistry, 21, no. 1 (2002),
https://hdl.handle.net/21.15107/rcub_ibiss_1807 .