TY  - JOUR
AU  - Matić, Gordana
AU  - Vojnović-Milutinović, Danijela
AU  - Brkljačić, Jelena
AU  - Elaković, Ivana
AU  - Manitašević-Jovanović, Sanja
AU  - Perišić, Tatjana
AU  - Dunđerski, Jadranka S.
AU  - Damjanović, Svetozar S
AU  - Knežević, Goran
AU  - Spirić, Zeljko M
AU  - Vermetten, Eric
AU  - Savić, Danka A
PY  - 2013
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/999
AB  - Objective: Posttraumatic stress disorder (PTSD) has been shown to be associated with altered glucocorticoid receptor (GR) activity. We studied the expression and functional properties of the receptor in peripheral blood mononuclear cells (PBMCs) from non-traumatized healthy individuals (healthy controls; n = 85), and war trauma-exposed individuals with current PTSD (n = 113), with life-time PTSD (n = 61) and without PTSD (trauma controls; n = 88). The aim of the study was to distinguish the receptor alterations related to PTSD from those related to trauma itself or to resilience to PTSD. Methods: Functional status of the receptor was assessed by radioligand binding and lysozyme synthesis inhibition assays. The level of GR gene expression was measured by quantitative PCR and immunoblotting. Results: Current PTSD patients had the lowest, while trauma controls had the highest number of glucocorticoid binding sites (B-max) in PBMCs. Hormone-binding potential (B-max/K-D ratio) of the receptor was diminished in the current PTSD group in comparison to all other study groups. Correlation between B-max and K-D that normally exists in healthy individuals was decreased in the current PTSD group. Contrasting B-max data, GR protein level was lower in trauma controls than in participants with current or life-time PTSD. Conclusions: Current PTSD is characterized by reduced lymphocyte GR hormone-binding potential and by disturbed compensation between B-max and hormone-binding affinity. Resilience to PTSD is associated with enlarged fraction of the receptor molecules capable of hormone binding, within the total receptor molecule population in PBMCs. (C) 2013 Elsevier Inc. All rights reserved.
T2  - Progress in Neuro-Psychopharmacology & Biological Psychiatry
T1  - Lymphocyte glucocorticoid receptor expression level and hormone-binding properties differ between war trauma-exposed men with and without PTSD
IS  - null
VL  - 43
SP  - 63
EP  - 245
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_999
ER  - 

@article{
author = "Matić, Gordana and Vojnović-Milutinović, Danijela and Brkljačić, Jelena and Elaković, Ivana and Manitašević-Jovanović, Sanja and Perišić, Tatjana and Dunđerski, Jadranka S. and Damjanović, Svetozar S and Knežević, Goran and Spirić, Zeljko M and Vermetten, Eric and Savić, Danka A",
year = "2013",
abstract = "Objective: Posttraumatic stress disorder (PTSD) has been shown to be associated with altered glucocorticoid receptor (GR) activity. We studied the expression and functional properties of the receptor in peripheral blood mononuclear cells (PBMCs) from non-traumatized healthy individuals (healthy controls; n = 85), and war trauma-exposed individuals with current PTSD (n = 113), with life-time PTSD (n = 61) and without PTSD (trauma controls; n = 88). The aim of the study was to distinguish the receptor alterations related to PTSD from those related to trauma itself or to resilience to PTSD. Methods: Functional status of the receptor was assessed by radioligand binding and lysozyme synthesis inhibition assays. The level of GR gene expression was measured by quantitative PCR and immunoblotting. Results: Current PTSD patients had the lowest, while trauma controls had the highest number of glucocorticoid binding sites (B-max) in PBMCs. Hormone-binding potential (B-max/K-D ratio) of the receptor was diminished in the current PTSD group in comparison to all other study groups. Correlation between B-max and K-D that normally exists in healthy individuals was decreased in the current PTSD group. Contrasting B-max data, GR protein level was lower in trauma controls than in participants with current or life-time PTSD. Conclusions: Current PTSD is characterized by reduced lymphocyte GR hormone-binding potential and by disturbed compensation between B-max and hormone-binding affinity. Resilience to PTSD is associated with enlarged fraction of the receptor molecules capable of hormone binding, within the total receptor molecule population in PBMCs. (C) 2013 Elsevier Inc. All rights reserved.",
journal = "Progress in Neuro-Psychopharmacology & Biological Psychiatry",
title = "Lymphocyte glucocorticoid receptor expression level and hormone-binding properties differ between war trauma-exposed men with and without PTSD",
number = "null",
volume = "43",
pages = "63-245",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_999"
}

Matić, G., Vojnović-Milutinović, D., Brkljačić, J., Elaković, I., Manitašević-Jovanović, S., Perišić, T., Dunđerski, J. S., Damjanović, S. S., Knežević, G., Spirić, Z. M., Vermetten, E.,& Savić, D. A.. (2013). Lymphocyte glucocorticoid receptor expression level and hormone-binding properties differ between war trauma-exposed men with and without PTSD. in Progress in Neuro-Psychopharmacology & Biological Psychiatry, 43(null), 63-245.
https://hdl.handle.net/21.15107/rcub_ibiss_999

Matić G, Vojnović-Milutinović D, Brkljačić J, Elaković I, Manitašević-Jovanović S, Perišić T, Dunđerski JS, Damjanović SS, Knežević G, Spirić ZM, Vermetten E, Savić DA. Lymphocyte glucocorticoid receptor expression level and hormone-binding properties differ between war trauma-exposed men with and without PTSD. in Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2013;43(null):63-245.
https://hdl.handle.net/21.15107/rcub_ibiss_999 .

Matić, Gordana, Vojnović-Milutinović, Danijela, Brkljačić, Jelena, Elaković, Ivana, Manitašević-Jovanović, Sanja, Perišić, Tatjana, Dunđerski, Jadranka S., Damjanović, Svetozar S, Knežević, Goran, Spirić, Zeljko M, Vermetten, Eric, Savić, Danka A, "Lymphocyte glucocorticoid receptor expression level and hormone-binding properties differ between war trauma-exposed men with and without PTSD" in Progress in Neuro-Psychopharmacology & Biological Psychiatry, 43, no. null (2013):63-245,
https://hdl.handle.net/21.15107/rcub_ibiss_999 .

TY  - JOUR
AU  - Manitašević-Jovanović, Sanja
AU  - Brkljačić, Jelena
AU  - Matić, Gordana
AU  - Tanić, Nikola T
AU  - Vojnović-Milutinović, Danijela
AU  - Elaković, Ivana
AU  - Perišić, Tatjana
AU  - Dunđerski, Jadranka S.
PY  - 2010
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1388
AB  - Background: Selection of appropriate endogenous control is a critical step in gene expression analysis. The aim of this study was to evaluate expression stability of four frequently used endogenous controls: beta-actin, glyceraldehyde-3-phosphate dehydrogenase, beta(2)-microglobulin and RNA polymerase II polypeptide A in peripheral blood mononuclear cells from war veterans with and without posttraumatic stress disorder (PTSD). The study was designed as to identify suitable reference gene(s) for normalization of gene expression in peripheral blood mononuclear cells in response to war trauma and/or PTSD. Results: The variability in expression of the four endogenous controls was assessed by TaqMan Real-time RT-PCR in peripheral blood mononuclear cells from: war veterans with current PTSD, those with lifetime PTSD, trauma controls and healthy subjects. Expression stability was analyzed by GeNorm and NormFinder software packages, and by direct comparison of Ct values. Both, GeNorm and NormFinder identified beta-actin and glyceraldehyde-3-phosphate dehydrogenase as a pair of genes with the lowest stability value. Conclusions: The combination of beta-actin and glyceraldehyde-3-phosphate dehydrogenase appeared to be the most suitable reference for studying alterations in gene expression in peripheral blood mononuclear cells related to vulnerability and resilience to PTSD, as well as to trauma-provoked developing of this disorder and recovery from it. Using glyceraldehyde-3-phosphate dehydrogenase, beta-actin and beta(2)-microglobulin as individual endogenous controls would provide satisfactory data, while RNA polymerase II polypeptide A could not be recommended.
T2  - Bmc Molecular Biology
T1  - Validation of endogenous controls for gene expression studies in peripheral lymphocytes from war veterans with and without PTSD
IS  - null
VL  - 11
EP  - na
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1388
ER  - 

@article{
author = "Manitašević-Jovanović, Sanja and Brkljačić, Jelena and Matić, Gordana and Tanić, Nikola T and Vojnović-Milutinović, Danijela and Elaković, Ivana and Perišić, Tatjana and Dunđerski, Jadranka S.",
year = "2010",
abstract = "Background: Selection of appropriate endogenous control is a critical step in gene expression analysis. The aim of this study was to evaluate expression stability of four frequently used endogenous controls: beta-actin, glyceraldehyde-3-phosphate dehydrogenase, beta(2)-microglobulin and RNA polymerase II polypeptide A in peripheral blood mononuclear cells from war veterans with and without posttraumatic stress disorder (PTSD). The study was designed as to identify suitable reference gene(s) for normalization of gene expression in peripheral blood mononuclear cells in response to war trauma and/or PTSD. Results: The variability in expression of the four endogenous controls was assessed by TaqMan Real-time RT-PCR in peripheral blood mononuclear cells from: war veterans with current PTSD, those with lifetime PTSD, trauma controls and healthy subjects. Expression stability was analyzed by GeNorm and NormFinder software packages, and by direct comparison of Ct values. Both, GeNorm and NormFinder identified beta-actin and glyceraldehyde-3-phosphate dehydrogenase as a pair of genes with the lowest stability value. Conclusions: The combination of beta-actin and glyceraldehyde-3-phosphate dehydrogenase appeared to be the most suitable reference for studying alterations in gene expression in peripheral blood mononuclear cells related to vulnerability and resilience to PTSD, as well as to trauma-provoked developing of this disorder and recovery from it. Using glyceraldehyde-3-phosphate dehydrogenase, beta-actin and beta(2)-microglobulin as individual endogenous controls would provide satisfactory data, while RNA polymerase II polypeptide A could not be recommended.",
journal = "Bmc Molecular Biology",
title = "Validation of endogenous controls for gene expression studies in peripheral lymphocytes from war veterans with and without PTSD",
number = "null",
volume = "11",
pages = "na",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1388"
}

Manitašević-Jovanović, S., Brkljačić, J., Matić, G., Tanić, N. T., Vojnović-Milutinović, D., Elaković, I., Perišić, T.,& Dunđerski, J. S.. (2010). Validation of endogenous controls for gene expression studies in peripheral lymphocytes from war veterans with and without PTSD. in Bmc Molecular Biology, 11(null).
https://hdl.handle.net/21.15107/rcub_ibiss_1388

Manitašević-Jovanović S, Brkljačić J, Matić G, Tanić NT, Vojnović-Milutinović D, Elaković I, Perišić T, Dunđerski JS. Validation of endogenous controls for gene expression studies in peripheral lymphocytes from war veterans with and without PTSD. in Bmc Molecular Biology. 2010;11(null):null-na.
https://hdl.handle.net/21.15107/rcub_ibiss_1388 .

Manitašević-Jovanović, Sanja, Brkljačić, Jelena, Matić, Gordana, Tanić, Nikola T, Vojnović-Milutinović, Danijela, Elaković, Ivana, Perišić, Tatjana, Dunđerski, Jadranka S., "Validation of endogenous controls for gene expression studies in peripheral lymphocytes from war veterans with and without PTSD" in Bmc Molecular Biology, 11, no. null (2010),
https://hdl.handle.net/21.15107/rcub_ibiss_1388 .

TY  - JOUR
AU  - Matić, Gordana
AU  - Dunđerski, Jadranka S.
PY  - 2009
PY  - 2009
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/494
AB  - Glucocorticoid hormones are essential for life, have a vital place in the treatment of inflammatory and autoimmune diseases and are increasingly implicated in the pathogenesis of a number of common disorders. Their action is mediated by an intracellular receptor protein, the glucocorticoid receptor (GR), functioning as a ligand-inducible transcription factor. Multiple synthetic glucocorticoids are used as potent antiinflammatory and immuno suppressive agents, but their therapeutic usefulness is limited by a wide range and severity of side-effects. One of the most important pharmaceutical goals has been to design steroidal and non-steroidal GR ligands with profound therapeutic efficacy and reduced unwanted effects. The therapeutic benefit of glucocorticoid agonists is frequently compromised by resistance to glucocorticoids, which may depend on: access of the hormones to target cells, steroid metabolism, expression level and isoform composition of the GR protein, mutations and polymorphisms in the GR gene and association of the receptor with chaperone proteins. The major breakthrough into the critical role of glucocorticoid signaling in the maintenance of homeostasis and pathogenesis of diseases, as well as into the molecular mechanisms underlying the therapeutic usefulness of antiinflammatory drugs acting through the GR is expected to result from the current progress in large-scale gene expression profiling technologies and computational biology.
AB  - Glukokortikoidni hormoni su neophodni za održavanje homeostaze, imaju ključnu ulogu u terapiji inflamatornih i autoimunih poremećaja i učestvuju u pato - genezi mnogih bolesti. Ovi hormoni deluju posredstvom unutarćelijskog receptornog proteina, glukokortikoidnog receptora, koji funkcioniše kao inducibilan transkripcioni faktor aktiviran ligandom. Mnogi sintetski glukokortikoidi koriste se kao efikasni antiinflamatorni i imunosupresivni agensi, ali je njihov terapeutski učinak ograničen širokim spektrom i intenzitetom sporednih efekata. Jedan od najvažnijih ciljeva farmaceutske industrije jeste sinteza steroidnih i nesteroidnih liganada GR-a sa izraženom terapeutskom efikasnošću i redukovanim neželjenim efektima. Terapeutski učinak glukokortikoidnih agonista često je umanjen zbog rezistencije na glukokortikoide koja zavisi od: dostupnosti ciljnih ćelija hormonima, metabolizma steroida, nivoa ekspresije i izoformskog sastava GR, mutacija i polimorfizama u genu za receptor i interakcije receptora sa šaperonima. Očekuje se da veliki prodor u upoznavanju ključne uloge glukokortikoidnih hormona u održavanju homeostaze i patogenezi bolesti, kao i u rasvetljavanju molekularnih mehanizama terapeutskih efekata antiinflamatornih lekova koji deluju posredstvom GR rezultira iz napretka savremenih tehnologija za globalno izučavanje ekspresije gena i bioinformatike.
T2  - Journal of Medical Biochemistry
T1  - Glukokortikoidni receptor u zdravlju i bolesti
T1  - Glucocorticoid receptor in health and disease
IS  - 4
VL  - 28
SP  - 248
EP  - 261
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_494
ER  - 

@article{
author = "Matić, Gordana and Dunđerski, Jadranka S.",
year = "2009, 2009",
abstract = "Glucocorticoid hormones are essential for life, have a vital place in the treatment of inflammatory and autoimmune diseases and are increasingly implicated in the pathogenesis of a number of common disorders. Their action is mediated by an intracellular receptor protein, the glucocorticoid receptor (GR), functioning as a ligand-inducible transcription factor. Multiple synthetic glucocorticoids are used as potent antiinflammatory and immuno suppressive agents, but their therapeutic usefulness is limited by a wide range and severity of side-effects. One of the most important pharmaceutical goals has been to design steroidal and non-steroidal GR ligands with profound therapeutic efficacy and reduced unwanted effects. The therapeutic benefit of glucocorticoid agonists is frequently compromised by resistance to glucocorticoids, which may depend on: access of the hormones to target cells, steroid metabolism, expression level and isoform composition of the GR protein, mutations and polymorphisms in the GR gene and association of the receptor with chaperone proteins. The major breakthrough into the critical role of glucocorticoid signaling in the maintenance of homeostasis and pathogenesis of diseases, as well as into the molecular mechanisms underlying the therapeutic usefulness of antiinflammatory drugs acting through the GR is expected to result from the current progress in large-scale gene expression profiling technologies and computational biology., Glukokortikoidni hormoni su neophodni za održavanje homeostaze, imaju ključnu ulogu u terapiji inflamatornih i autoimunih poremećaja i učestvuju u pato - genezi mnogih bolesti. Ovi hormoni deluju posredstvom unutarćelijskog receptornog proteina, glukokortikoidnog receptora, koji funkcioniše kao inducibilan transkripcioni faktor aktiviran ligandom. Mnogi sintetski glukokortikoidi koriste se kao efikasni antiinflamatorni i imunosupresivni agensi, ali je njihov terapeutski učinak ograničen širokim spektrom i intenzitetom sporednih efekata. Jedan od najvažnijih ciljeva farmaceutske industrije jeste sinteza steroidnih i nesteroidnih liganada GR-a sa izraženom terapeutskom efikasnošću i redukovanim neželjenim efektima. Terapeutski učinak glukokortikoidnih agonista često je umanjen zbog rezistencije na glukokortikoide koja zavisi od: dostupnosti ciljnih ćelija hormonima, metabolizma steroida, nivoa ekspresije i izoformskog sastava GR, mutacija i polimorfizama u genu za receptor i interakcije receptora sa šaperonima. Očekuje se da veliki prodor u upoznavanju ključne uloge glukokortikoidnih hormona u održavanju homeostaze i patogenezi bolesti, kao i u rasvetljavanju molekularnih mehanizama terapeutskih efekata antiinflamatornih lekova koji deluju posredstvom GR rezultira iz napretka savremenih tehnologija za globalno izučavanje ekspresije gena i bioinformatike.",
journal = "Journal of Medical Biochemistry",
title = "Glukokortikoidni receptor u zdravlju i bolesti, Glucocorticoid receptor in health and disease",
number = "4",
volume = "28",
pages = "248-261",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_494"
}

Matić, G.,& Dunđerski, J. S.. (2009). Glukokortikoidni receptor u zdravlju i bolesti. in Journal of Medical Biochemistry, 28(4), 248-261.
https://hdl.handle.net/21.15107/rcub_ibiss_494

Matić G, Dunđerski JS. Glukokortikoidni receptor u zdravlju i bolesti. in Journal of Medical Biochemistry. 2009;28(4):248-261.
https://hdl.handle.net/21.15107/rcub_ibiss_494 .

Matić, Gordana, Dunđerski, Jadranka S., "Glukokortikoidni receptor u zdravlju i bolesti" in Journal of Medical Biochemistry, 28, no. 4 (2009):248-261,
https://hdl.handle.net/21.15107/rcub_ibiss_494 .

TY  - JOUR
AU  - Manitašević, Sanja
AU  - Dunđerski, Jadranka S.
AU  - Matić, Gordana
AU  - Tucić, Branka
PY  - 2007
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1621
AB  - Seasonal variation in heat shock proteins Hsp70 and Hsp90 expression was studied in the leaves of two naturally growing Iris pumila populations, one inhabiting an open dune site, and the other the understorey of a Pinus silvestris stand. The Hsps were quantified by an immunoblotting procedure. The level of the Hsps was found to vary significantly both across seasons and between habitats. The mean Hsp70 concentration was significantly greater at the open area than in the woodland understorey, reaching its maximum in the summer, especially in plants experiencing full sunlight. Two Hsp90 isoforms, referred to as Hsp90a (86 kDa) and Hsp90b (84 kDa), were detected. At both habitats, the level of Hsp90a was highest in autumn, that of Hsp90b in spring, whereas both of them reached a nadir in summer. Throughout the growing season, the relative abundance of Hsp90b was higher in plants growing under vegetation canopy in comparison to those inhabiting the open dune site. An inverse relationship between the phenotypic variation in specific leaf area and the level of Hsp90b over seasons at both habitats was observed, suggesting the role of this protein in buffering phenotypic variation in the wild.
T2  - Plant Cell and Environment
T1  - Seasonal variation in heat shock proteins Hsp70 and Hsp90 expression in an exposed and a shaded habitat of Iris pumila
IS  - 1
VL  - 30
EP  - 11
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1621
ER  - 

@article{
author = "Manitašević, Sanja and Dunđerski, Jadranka S. and Matić, Gordana and Tucić, Branka",
year = "2007",
abstract = "Seasonal variation in heat shock proteins Hsp70 and Hsp90 expression was studied in the leaves of two naturally growing Iris pumila populations, one inhabiting an open dune site, and the other the understorey of a Pinus silvestris stand. The Hsps were quantified by an immunoblotting procedure. The level of the Hsps was found to vary significantly both across seasons and between habitats. The mean Hsp70 concentration was significantly greater at the open area than in the woodland understorey, reaching its maximum in the summer, especially in plants experiencing full sunlight. Two Hsp90 isoforms, referred to as Hsp90a (86 kDa) and Hsp90b (84 kDa), were detected. At both habitats, the level of Hsp90a was highest in autumn, that of Hsp90b in spring, whereas both of them reached a nadir in summer. Throughout the growing season, the relative abundance of Hsp90b was higher in plants growing under vegetation canopy in comparison to those inhabiting the open dune site. An inverse relationship between the phenotypic variation in specific leaf area and the level of Hsp90b over seasons at both habitats was observed, suggesting the role of this protein in buffering phenotypic variation in the wild.",
journal = "Plant Cell and Environment",
title = "Seasonal variation in heat shock proteins Hsp70 and Hsp90 expression in an exposed and a shaded habitat of Iris pumila",
number = "1",
volume = "30",
pages = "11",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1621"
}

Manitašević, S., Dunđerski, J. S., Matić, G.,& Tucić, B.. (2007). Seasonal variation in heat shock proteins Hsp70 and Hsp90 expression in an exposed and a shaded habitat of Iris pumila. in Plant Cell and Environment, 30(1).
https://hdl.handle.net/21.15107/rcub_ibiss_1621

Manitašević S, Dunđerski JS, Matić G, Tucić B. Seasonal variation in heat shock proteins Hsp70 and Hsp90 expression in an exposed and a shaded habitat of Iris pumila. in Plant Cell and Environment. 2007;30(1):null-11.
https://hdl.handle.net/21.15107/rcub_ibiss_1621 .

Manitašević, Sanja, Dunđerski, Jadranka S., Matić, Gordana, Tucić, Branka, "Seasonal variation in heat shock proteins Hsp70 and Hsp90 expression in an exposed and a shaded habitat of Iris pumila" in Plant Cell and Environment, 30, no. 1 (2007),
https://hdl.handle.net/21.15107/rcub_ibiss_1621 .

TY  - JOUR
AU  - Vasiljević, Đ.
AU  - Brkljačić, Jelena
AU  - Papić, D.
AU  - Vojnović-Milutinović, Danijela
AU  - Dunđerski, Jadranka S.
PY  - 2007
PY  - 2007
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/157
T2  - Archives of Biological Sciences
T1  - HSP70 level in the leaves of Phaseolus vulgaris intoxicated with cadmium.
IS  - 2
VL  - 59
SP  - 27
EP  - 28
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_157
ER  - 

@article{
author = "Vasiljević, Đ. and Brkljačić, Jelena and Papić, D. and Vojnović-Milutinović, Danijela and Dunđerski, Jadranka S.",
year = "2007, 2007",
journal = "Archives of Biological Sciences",
title = "HSP70 level in the leaves of Phaseolus vulgaris intoxicated with cadmium.",
number = "2",
volume = "59",
pages = "27-28",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_157"
}

Vasiljević, Đ., Brkljačić, J., Papić, D., Vojnović-Milutinović, D.,& Dunđerski, J. S.. (2007). HSP70 level in the leaves of Phaseolus vulgaris intoxicated with cadmium.. in Archives of Biological Sciences, 59(2), 27-28.
https://hdl.handle.net/21.15107/rcub_ibiss_157

Vasiljević Đ, Brkljačić J, Papić D, Vojnović-Milutinović D, Dunđerski JS. HSP70 level in the leaves of Phaseolus vulgaris intoxicated with cadmium.. in Archives of Biological Sciences. 2007;59(2):27-28.
https://hdl.handle.net/21.15107/rcub_ibiss_157 .

Vasiljević, Đ., Brkljačić, Jelena, Papić, D., Vojnović-Milutinović, Danijela, Dunđerski, Jadranka S., "HSP70 level in the leaves of Phaseolus vulgaris intoxicated with cadmium." in Archives of Biological Sciences, 59, no. 2 (2007):27-28,
https://hdl.handle.net/21.15107/rcub_ibiss_157 .

TY  - CONF
AU  - Brkljačić, Jelena
AU  - Vojnović-Milutinović, Danijela
AU  - Dunđerski, Jadranka S.
AU  - Matić, Gordana
PY  - 2005
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1700
C3  - Febs Journal
T1  - Association of rat liver glucocorticoid receptor with Hsp90 and Hsp70 upon mercury intoxication
VL  - 272
EP  - 481
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1700
ER  - 

@conference{
author = "Brkljačić, Jelena and Vojnović-Milutinović, Danijela and Dunđerski, Jadranka S. and Matić, Gordana",
year = "2005",
journal = "Febs Journal",
title = "Association of rat liver glucocorticoid receptor with Hsp90 and Hsp70 upon mercury intoxication",
volume = "272",
pages = "481",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1700"
}

Brkljačić, J., Vojnović-Milutinović, D., Dunđerski, J. S.,& Matić, G.. (2005). Association of rat liver glucocorticoid receptor with Hsp90 and Hsp70 upon mercury intoxication. in Febs Journal, 272.
https://hdl.handle.net/21.15107/rcub_ibiss_1700

Brkljačić J, Vojnović-Milutinović D, Dunđerski JS, Matić G. Association of rat liver glucocorticoid receptor with Hsp90 and Hsp70 upon mercury intoxication. in Febs Journal. 2005;272:null-481.
https://hdl.handle.net/21.15107/rcub_ibiss_1700 .

Brkljačić, Jelena, Vojnović-Milutinović, Danijela, Dunđerski, Jadranka S., Matić, Gordana, "Association of rat liver glucocorticoid receptor with Hsp90 and Hsp70 upon mercury intoxication" in Febs Journal, 272 (2005),
https://hdl.handle.net/21.15107/rcub_ibiss_1700 .

TY  - JOUR
AU  - Dunđerski, Jadranka S.
PY  - 2004
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/30
AB  - All cells respond to various types of stress by increasing the transcription of specific genes that encode class of proteins termed stress proteins. This response is believed to represent a transient reprogramming of gene expression and biological activity, which serves to protect sensitive cellular components from damage, and assists in the rapid recovery after the stress is removed or ceases. The synthesis of stress proteins can be induced under a host of different stress conditions, including elevated level of metals. Although, understanding of the relationships between metals and their capacity to induce stress response is incomplete, these interactions are important to consider because they may reveal information regarding mechanisms of toxicity, cellular defense mechanisms against metal toxicity, and biochemical responses which can be exploited as biomarkers of exposure and toxicity of metals. This review is focused on two main classes of stress proteins, metallothioneins (MTs) and heat shock proteins (Hsps), which are usually induced in response to stress provoked by metals. It summarizes the results of studies on metals toxic effects and their ability to induce cellular stress response.
AB  - Sve žive ćelije odgovaraju na različite tipove stresa povećavanjem transkripcije specifičnih gena koji kodiraju klasu proteina nazvanih stres proteini. Taj odgovor predstavlja prolazno reprogramiranje ekspresije gena i biološke aktivnosti, i služi da zaštiti osetljive ćelijske komponente od oštećenja, i pomogne u brzom oporavku posle uklanjanja ili prestanka delovanja stresa. Sinteza proteina stresa može biti indukovana pod delovanjem različitih stresogenih uslova, uključujući i povećani nivo metala. Pošto je razumevanje odnosa između metala i njihovog kapaciteta da indukuju odgovor na stres nedovoljno poznato, njihovo proučavanje je važno zato što može dati informacije o mehanizmima toksičnosti metala, ćelijskim odbrambenim mehanizmima i biohemijskim odgovorima koji se mogu koristiti kao biomarkeri izlaganja ili toksičnosti metala. Ovaj revijski članak je fokusiran na dve klase stres proteina, metalotioneina (MT) i proteina toplotnog stresa (Hsp), koje se najčešće indukuju u odgovoru na stres provociran metalima. Sumirani su rezultati istraživanja toksičnih efekata metala i njihove sposobnosti da indukuju ćelijski odgovor na stres.
T2  - Jugoslovenska medicinska biohemija
T1  - Ćeluski odgovor na stres - odbrana od toksičnih efekata metala
T1  - Cellular stress response: Defence against metal toxicity
IS  - 1
VL  - 23
SP  - 1
EP  - 9
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_30
ER  - 

@article{
author = "Dunđerski, Jadranka S.",
year = "2004",
abstract = "All cells respond to various types of stress by increasing the transcription of specific genes that encode class of proteins termed stress proteins. This response is believed to represent a transient reprogramming of gene expression and biological activity, which serves to protect sensitive cellular components from damage, and assists in the rapid recovery after the stress is removed or ceases. The synthesis of stress proteins can be induced under a host of different stress conditions, including elevated level of metals. Although, understanding of the relationships between metals and their capacity to induce stress response is incomplete, these interactions are important to consider because they may reveal information regarding mechanisms of toxicity, cellular defense mechanisms against metal toxicity, and biochemical responses which can be exploited as biomarkers of exposure and toxicity of metals. This review is focused on two main classes of stress proteins, metallothioneins (MTs) and heat shock proteins (Hsps), which are usually induced in response to stress provoked by metals. It summarizes the results of studies on metals toxic effects and their ability to induce cellular stress response., Sve žive ćelije odgovaraju na različite tipove stresa povećavanjem transkripcije specifičnih gena koji kodiraju klasu proteina nazvanih stres proteini. Taj odgovor predstavlja prolazno reprogramiranje ekspresije gena i biološke aktivnosti, i služi da zaštiti osetljive ćelijske komponente od oštećenja, i pomogne u brzom oporavku posle uklanjanja ili prestanka delovanja stresa. Sinteza proteina stresa može biti indukovana pod delovanjem različitih stresogenih uslova, uključujući i povećani nivo metala. Pošto je razumevanje odnosa između metala i njihovog kapaciteta da indukuju odgovor na stres nedovoljno poznato, njihovo proučavanje je važno zato što može dati informacije o mehanizmima toksičnosti metala, ćelijskim odbrambenim mehanizmima i biohemijskim odgovorima koji se mogu koristiti kao biomarkeri izlaganja ili toksičnosti metala. Ovaj revijski članak je fokusiran na dve klase stres proteina, metalotioneina (MT) i proteina toplotnog stresa (Hsp), koje se najčešće indukuju u odgovoru na stres provociran metalima. Sumirani su rezultati istraživanja toksičnih efekata metala i njihove sposobnosti da indukuju ćelijski odgovor na stres.",
journal = "Jugoslovenska medicinska biohemija",
title = "Ćeluski odgovor na stres - odbrana od toksičnih efekata metala, Cellular stress response: Defence against metal toxicity",
number = "1",
volume = "23",
pages = "1-9",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_30"
}

Dunđerski, J. S.. (2004). Ćeluski odgovor na stres - odbrana od toksičnih efekata metala. in Jugoslovenska medicinska biohemija, 23(1), 1-9.
https://hdl.handle.net/21.15107/rcub_ibiss_30

Dunđerski JS. Ćeluski odgovor na stres - odbrana od toksičnih efekata metala. in Jugoslovenska medicinska biohemija. 2004;23(1):1-9.
https://hdl.handle.net/21.15107/rcub_ibiss_30 .

Dunđerski, Jadranka S., "Ćeluski odgovor na stres - odbrana od toksičnih efekata metala" in Jugoslovenska medicinska biohemija, 23, no. 1 (2004):1-9,
https://hdl.handle.net/21.15107/rcub_ibiss_30 .

TY  - JOUR
AU  - Dunđerski, Jadranka S.
AU  - Vidović, Stojko
AU  - Matić, Gordana
PY  - 2003
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/24
AB  - The aim of the present study was to examine the influence of dexamethasone on the levels of heat shock protein Hsp70 and glucocorticoid hormones receptor as well as on the interaction of these two proteins in the liver cytosol and nuclei of unstressed and rats exposed to whole body hyperthermic stress. The results, obtained by quantitative immunoblotting, have shown that dexamethasone provoked a reduction of Hsp70 basal level and an increase in its stress-induced level in the nuclei, supporting the idea that this hormone may be a factor included in the regulation of Hsp70 level both under normal and stress conditions. The cytosolic reduction and nuclear elevation of the glucocorticoid hormones receptor level by dexamethasone were also observed. Co-immunopurification of Hsp70 and glucocorticoid hormones receptor has revealed that the changes of cytosolic and nuclear levels of the two examined proteins resulted in the changes of their interaction within the respective cellular compartments. Thus, 41 °C heat stress was shown to cause at least two-fold elevation of Hsp70/GR ratio within the glucocorticoid hormones receptor heterocomplexes both in the presence and in the absence of dexamethasone. The results support the view that glucocorticoid hormones signaling pathway and heat shock system are interrelated.
AB  - Cilj ovog rada bio je da se ispita uticaj deksametazona na koncentraciju proteina toplotnog stresa Hsp70 i glukokortikoidnog receptora (GR), kao i na interakciju ovih proteina, u citosolu i jedrima jetre nestresiranih pacova i pacova izloženih hipertermijskom stresu. Rezultati, dobijeni kvantitativnim imunoblotom, su pokazali da deksametazon dovodi do smanjenja bazalne i povećanja stresom indukovane koncentracije Hsp70 u jedrima, što ukazuje na mogućnost da je ovaj hormon jedan od faktora uključenih u regulaciju nivoa Hsp70 i u normalnim i u uslovima stresa. Zapaženo je i to da deksametazon uzrokuje smanjenje citosolne i povećanje jedarne koncentracije GR. Ko-imunopurifikacija Hsp70 i GR je pokazala da su promene u citosolnim i jedarnim koncentracijama ovih proteina praćene i promenama u njihovoj interakciji u odgovarajućim ćelijskim odeljcima. Tako, nađeno je da hipertermijski stres (41 °C) dovodi do najmanje dvostrukog povećanja odnosa Hsp70/GR u receptorskim heterokompleksima kako u prisustvu, tako i u odsustvu deksametazona. Rezultati podržavaju pretpostavku da su signalni putevi koje započinju glukokortikoidni hormoni i toplotni stres međusobno povezani.
T2  - Jugoslovenska medicinska biohemija
T1  - Uticaj deksametazona na koncentraciju i interakciju Hsp70 sa glukokortikoidnim receptorom u jetri nestresiranih i pacova izloženih toplotnom stresu
T1  - The influence of dexamethasone on Hsp70 level and association with glucocorticoid receptor in the liver of unstressed and heat-stressed rats
IS  - 1
VL  - 22
SP  - 19
EP  - 26
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_24
ER  - 

@article{
author = "Dunđerski, Jadranka S. and Vidović, Stojko and Matić, Gordana",
year = "2003",
abstract = "The aim of the present study was to examine the influence of dexamethasone on the levels of heat shock protein Hsp70 and glucocorticoid hormones receptor as well as on the interaction of these two proteins in the liver cytosol and nuclei of unstressed and rats exposed to whole body hyperthermic stress. The results, obtained by quantitative immunoblotting, have shown that dexamethasone provoked a reduction of Hsp70 basal level and an increase in its stress-induced level in the nuclei, supporting the idea that this hormone may be a factor included in the regulation of Hsp70 level both under normal and stress conditions. The cytosolic reduction and nuclear elevation of the glucocorticoid hormones receptor level by dexamethasone were also observed. Co-immunopurification of Hsp70 and glucocorticoid hormones receptor has revealed that the changes of cytosolic and nuclear levels of the two examined proteins resulted in the changes of their interaction within the respective cellular compartments. Thus, 41 °C heat stress was shown to cause at least two-fold elevation of Hsp70/GR ratio within the glucocorticoid hormones receptor heterocomplexes both in the presence and in the absence of dexamethasone. The results support the view that glucocorticoid hormones signaling pathway and heat shock system are interrelated., Cilj ovog rada bio je da se ispita uticaj deksametazona na koncentraciju proteina toplotnog stresa Hsp70 i glukokortikoidnog receptora (GR), kao i na interakciju ovih proteina, u citosolu i jedrima jetre nestresiranih pacova i pacova izloženih hipertermijskom stresu. Rezultati, dobijeni kvantitativnim imunoblotom, su pokazali da deksametazon dovodi do smanjenja bazalne i povećanja stresom indukovane koncentracije Hsp70 u jedrima, što ukazuje na mogućnost da je ovaj hormon jedan od faktora uključenih u regulaciju nivoa Hsp70 i u normalnim i u uslovima stresa. Zapaženo je i to da deksametazon uzrokuje smanjenje citosolne i povećanje jedarne koncentracije GR. Ko-imunopurifikacija Hsp70 i GR je pokazala da su promene u citosolnim i jedarnim koncentracijama ovih proteina praćene i promenama u njihovoj interakciji u odgovarajućim ćelijskim odeljcima. Tako, nađeno je da hipertermijski stres (41 °C) dovodi do najmanje dvostrukog povećanja odnosa Hsp70/GR u receptorskim heterokompleksima kako u prisustvu, tako i u odsustvu deksametazona. Rezultati podržavaju pretpostavku da su signalni putevi koje započinju glukokortikoidni hormoni i toplotni stres međusobno povezani.",
journal = "Jugoslovenska medicinska biohemija",
title = "Uticaj deksametazona na koncentraciju i interakciju Hsp70 sa glukokortikoidnim receptorom u jetri nestresiranih i pacova izloženih toplotnom stresu, The influence of dexamethasone on Hsp70 level and association with glucocorticoid receptor in the liver of unstressed and heat-stressed rats",
number = "1",
volume = "22",
pages = "19-26",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_24"
}

Dunđerski, J. S., Vidović, S.,& Matić, G.. (2003). Uticaj deksametazona na koncentraciju i interakciju Hsp70 sa glukokortikoidnim receptorom u jetri nestresiranih i pacova izloženih toplotnom stresu. in Jugoslovenska medicinska biohemija, 22(1), 19-26.
https://hdl.handle.net/21.15107/rcub_ibiss_24

Dunđerski JS, Vidović S, Matić G. Uticaj deksametazona na koncentraciju i interakciju Hsp70 sa glukokortikoidnim receptorom u jetri nestresiranih i pacova izloženih toplotnom stresu. in Jugoslovenska medicinska biohemija. 2003;22(1):19-26.
https://hdl.handle.net/21.15107/rcub_ibiss_24 .

Dunđerski, Jadranka S., Vidović, Stojko, Matić, Gordana, "Uticaj deksametazona na koncentraciju i interakciju Hsp70 sa glukokortikoidnim receptorom u jetri nestresiranih i pacova izloženih toplotnom stresu" in Jugoslovenska medicinska biohemija, 22, no. 1 (2003):19-26,
https://hdl.handle.net/21.15107/rcub_ibiss_24 .

TY  - JOUR
AU  - Dunđerski, Jadranka S.
AU  - Predić, Jelena
AU  - Čvoro, Aleksandra
AU  - Matić, Gordana
PY  - 2003
PY  - 2003
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/90
AB  - This study was focused on Cd effects on basal and dexamethasone-induced tyrosine aminotransferase (TAT) activity in the rat liver cytosol. Cadmium (Cd), applied in the dose of 2 mg/kg b.w., stimulated both TAT activity and its induction by dexamethasone, inducing the most prominent alterations 24 h after administration. Doses lower than 2 mg Cd/kg b.w. were ineffective while the higher ones (3 and 4 mg Cd/kg b.w) led to the changes similar to those reached by 2 mg Cd/kg. The in vitro application of different Cd concentrations to the liver cytosol rendered the enzyme activity unchanged suggesting that the metal acted at the level of TAT gene transcription.
AB  - Istraživanja su bila usmerena ka praćenju efekata Cd na osnovnu i deksametazonom indukovanu aktivnost tirozin aminotransferaze (TAT) u citosolu jetre pacova. Kadmijum (Cd) primenjen u dozi od 2 mg/kg telesne težine, stimulisao je i aktivnost TAT i indukciju enzima deksametazonom. Najizraženije promene su zapažene 24 h nakon injeciranja metala životinjama. Doze niže od 2mg/kg telesne težine nisu uticale na aktivnost enzima, dok su promene u prisustvu viših doza (3 i 4 mg Cd/kg telesne težine) bile približne onim zapaženim nakon tretiranja životinja sa 2 mg Cd/kg. Nepromenjena aktivnost enzima uočena nakon inkubiranja citosola jetre pacova sa različitim koncentracija Cd, sugerisala je da se uticaj metala ostvaruje na nivou transkripcije gena za tirozin aminotransferazu.
T2  - Archives of Biological Sciences
T1  - Aktivnost tirozin aminotransferaze u jetri pacova i indukcija enzima deksametazonom u uslovima intoksikacije kadmijumom
T1  - Rat liver tyrosine aminotransferase activity and induction by dexamethasone upon cadmium intoxication
IS  - 1-2
VL  - 55
SP  - 3
EP  - 7
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_90
ER  - 

@article{
author = "Dunđerski, Jadranka S. and Predić, Jelena and Čvoro, Aleksandra and Matić, Gordana",
year = "2003, 2003",
abstract = "This study was focused on Cd effects on basal and dexamethasone-induced tyrosine aminotransferase (TAT) activity in the rat liver cytosol. Cadmium (Cd), applied in the dose of 2 mg/kg b.w., stimulated both TAT activity and its induction by dexamethasone, inducing the most prominent alterations 24 h after administration. Doses lower than 2 mg Cd/kg b.w. were ineffective while the higher ones (3 and 4 mg Cd/kg b.w) led to the changes similar to those reached by 2 mg Cd/kg. The in vitro application of different Cd concentrations to the liver cytosol rendered the enzyme activity unchanged suggesting that the metal acted at the level of TAT gene transcription., Istraživanja su bila usmerena ka praćenju efekata Cd na osnovnu i deksametazonom indukovanu aktivnost tirozin aminotransferaze (TAT) u citosolu jetre pacova. Kadmijum (Cd) primenjen u dozi od 2 mg/kg telesne težine, stimulisao je i aktivnost TAT i indukciju enzima deksametazonom. Najizraženije promene su zapažene 24 h nakon injeciranja metala životinjama. Doze niže od 2mg/kg telesne težine nisu uticale na aktivnost enzima, dok su promene u prisustvu viših doza (3 i 4 mg Cd/kg telesne težine) bile približne onim zapaženim nakon tretiranja životinja sa 2 mg Cd/kg. Nepromenjena aktivnost enzima uočena nakon inkubiranja citosola jetre pacova sa različitim koncentracija Cd, sugerisala je da se uticaj metala ostvaruje na nivou transkripcije gena za tirozin aminotransferazu.",
journal = "Archives of Biological Sciences",
title = "Aktivnost tirozin aminotransferaze u jetri pacova i indukcija enzima deksametazonom u uslovima intoksikacije kadmijumom, Rat liver tyrosine aminotransferase activity and induction by dexamethasone upon cadmium intoxication",
number = "1-2",
volume = "55",
pages = "3-7",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_90"
}

Dunđerski, J. S., Predić, J., Čvoro, A.,& Matić, G.. (2003). Aktivnost tirozin aminotransferaze u jetri pacova i indukcija enzima deksametazonom u uslovima intoksikacije kadmijumom. in Archives of Biological Sciences, 55(1-2), 3-7.
https://hdl.handle.net/21.15107/rcub_ibiss_90

Dunđerski JS, Predić J, Čvoro A, Matić G. Aktivnost tirozin aminotransferaze u jetri pacova i indukcija enzima deksametazonom u uslovima intoksikacije kadmijumom. in Archives of Biological Sciences. 2003;55(1-2):3-7.
https://hdl.handle.net/21.15107/rcub_ibiss_90 .

Dunđerski, Jadranka S., Predić, Jelena, Čvoro, Aleksandra, Matić, Gordana, "Aktivnost tirozin aminotransferaze u jetri pacova i indukcija enzima deksametazonom u uslovima intoksikacije kadmijumom" in Archives of Biological Sciences, 55, no. 1-2 (2003):3-7,
https://hdl.handle.net/21.15107/rcub_ibiss_90 .

TY  - JOUR
AU  - Dunđerski, Jadranka S.
AU  - Predić, Jelena
AU  - Kovač, Tanja
AU  - Pavković, Nada
AU  - Ivanišević, Ljubica
AU  - Čvoro, Aleksandra
AU  - Matić, Gordana
PY  - 2000
PY  - 2000
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/58
AB  - The participation of metallothionein (Mt) and heat shock proteins (Hsps) in protection of glucocorticoid receptor (GR) binding capacity from a toxic metal cadmium (Cd), was investigated. Specific binding of a glucocorticoid to GR in the rat liver cytosol was studied after in vitro and in vivo Cd treatment. Reduction of the GR binding capacity observed after in vitro treatment was proportional to the applied metal concentrations. In animals administered different Cd doses, GR binding capacity was not reduced, except in those that received the highest dose, and a concomitant elevation of Mt, Hsp70 and Hsp90 levels was detected. The results led to the assumption that Cd-induced reduction of the GR binding capacity noticed in vitro, was prevented in intact animals by the elevated levels of Mt and Hsps.
AB  - Ispitivano je učešće metalotioneina (Mt) i proteina toplotnog stresa (Hsp)y zapititi glukokortikoidnog receptora (GR) od toksičnog delovanja kadmijuma (Cd). Specifično vezivanje glukokortikoida za GRy citosolu jetre pacova praćeno je posle in vitro i in vivo tretmana kadmijumom. Zapaženo je da je u in vitro uslovima smanjenje sposobnosti GR da vezuje hormon proporcionalno primenjenoj koncentraciji metala. Kod životinja injeciranih različitim dozama Cd, kapacitet GR za vezivanje hormona je nepromenjen osim u prisustvu najveće doze, i istovremeno se uočava povećanje koncentracije Mt, Hsp70 i Hsp90. Dobijeni rezultati ukazuju da je smanjena sposobnost GR za vezivanje hormona zapažena nakon in vitro tretmana kadmijumom, kod životinja injeciranih kadmijumom sprečena povećanom indukcijom Mt i Hsp.
T2  - Archives of Biological Sciences
T1  - Moguća uloga metalotioneina i proteina toplotnog stresa u zaštiti glukokokortikoidnog receptora u uslovima trovanja kadmijumom
T1  - A possible role of metallothionein and heat shock proteins in glucocorticoid receptor protection against cadmium intoxication
IS  - 2
VL  - 52
SP  - 89
EP  - 95
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_58
ER  - 

@article{
author = "Dunđerski, Jadranka S. and Predić, Jelena and Kovač, Tanja and Pavković, Nada and Ivanišević, Ljubica and Čvoro, Aleksandra and Matić, Gordana",
year = "2000, 2000",
abstract = "The participation of metallothionein (Mt) and heat shock proteins (Hsps) in protection of glucocorticoid receptor (GR) binding capacity from a toxic metal cadmium (Cd), was investigated. Specific binding of a glucocorticoid to GR in the rat liver cytosol was studied after in vitro and in vivo Cd treatment. Reduction of the GR binding capacity observed after in vitro treatment was proportional to the applied metal concentrations. In animals administered different Cd doses, GR binding capacity was not reduced, except in those that received the highest dose, and a concomitant elevation of Mt, Hsp70 and Hsp90 levels was detected. The results led to the assumption that Cd-induced reduction of the GR binding capacity noticed in vitro, was prevented in intact animals by the elevated levels of Mt and Hsps., Ispitivano je učešće metalotioneina (Mt) i proteina toplotnog stresa (Hsp)y zapititi glukokortikoidnog receptora (GR) od toksičnog delovanja kadmijuma (Cd). Specifično vezivanje glukokortikoida za GRy citosolu jetre pacova praćeno je posle in vitro i in vivo tretmana kadmijumom. Zapaženo je da je u in vitro uslovima smanjenje sposobnosti GR da vezuje hormon proporcionalno primenjenoj koncentraciji metala. Kod životinja injeciranih različitim dozama Cd, kapacitet GR za vezivanje hormona je nepromenjen osim u prisustvu najveće doze, i istovremeno se uočava povećanje koncentracije Mt, Hsp70 i Hsp90. Dobijeni rezultati ukazuju da je smanjena sposobnost GR za vezivanje hormona zapažena nakon in vitro tretmana kadmijumom, kod životinja injeciranih kadmijumom sprečena povećanom indukcijom Mt i Hsp.",
journal = "Archives of Biological Sciences",
title = "Moguća uloga metalotioneina i proteina toplotnog stresa u zaštiti glukokokortikoidnog receptora u uslovima trovanja kadmijumom, A possible role of metallothionein and heat shock proteins in glucocorticoid receptor protection against cadmium intoxication",
number = "2",
volume = "52",
pages = "89-95",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_58"
}

Dunđerski, J. S., Predić, J., Kovač, T., Pavković, N., Ivanišević, L., Čvoro, A.,& Matić, G.. (2000). Moguća uloga metalotioneina i proteina toplotnog stresa u zaštiti glukokokortikoidnog receptora u uslovima trovanja kadmijumom. in Archives of Biological Sciences, 52(2), 89-95.
https://hdl.handle.net/21.15107/rcub_ibiss_58

Dunđerski JS, Predić J, Kovač T, Pavković N, Ivanišević L, Čvoro A, Matić G. Moguća uloga metalotioneina i proteina toplotnog stresa u zaštiti glukokokortikoidnog receptora u uslovima trovanja kadmijumom. in Archives of Biological Sciences. 2000;52(2):89-95.
https://hdl.handle.net/21.15107/rcub_ibiss_58 .

Dunđerski, Jadranka S., Predić, Jelena, Kovač, Tanja, Pavković, Nada, Ivanišević, Ljubica, Čvoro, Aleksandra, Matić, Gordana, "Moguća uloga metalotioneina i proteina toplotnog stresa u zaštiti glukokokortikoidnog receptora u uslovima trovanja kadmijumom" in Archives of Biological Sciences, 52, no. 2 (2000):89-95,
https://hdl.handle.net/21.15107/rcub_ibiss_58 .