TY  - JOUR
AU  - Mihajlović, Ekatarina
AU  - Biancalana, Lorenzo
AU  - Jelača, Sanja
AU  - Chiaverini, Lorenzo
AU  - Dojčinović, Biljana
AU  - Dunđerović, Duško
AU  - Zacchini, Stefano
AU  - Mijatović, Sanja
AU  - Maksimović-Ivanić, Danijela
AU  - Marchetti, Fabio
PY  - 2024
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6701
AB  - FETPY, an organo-diiron(I) complex, showed strong cytotoxicity across a panel of human and mouse cancer cell lines, combined with an outstanding selectivity compared to nonmalignant cells. Enhanced iron uptake in aggressive, low-differentiated cell lines, caused membrane lipid peroxidation, which resulted in ferroptosis in human ovarian cancer cells. FETPY induced significant morphological changes in murine B16–F1 and B16–F10 melanoma cells, leading to senescence and/or trans-differentiation into Schwann-like cells, thus significantly reducing their tumorigenic potential. Additionally, FETPY substantially suppressed tumor growth in low- and high-grade syngeneic melanoma models when administered in a therapeutic regimen. FETPY is featured by satisfactory water solubility (millimolar range), an amphiphilic character (Log Pow = −0.17), and excellent stability in a biological medium (DMEM). These important requisites for drug development are rarely met in iron complexes investigated so far as possible anticancer agents. Overall, FETPY holds promise as a safe and potent targeted antitumor agent.
PB  - American Chemical Society
T2  - Journal of Medicinal Chemistry
T1  - FETPY: a Diiron(I) Thio–Carbyne Complex with Prominent Anticancer Activity In Vitro and In Vivo
IS  - 9
VL  - 67
DO  - 10.1021/acs.jmedchem.4c00377
SP  - 7553
EP  - 7568
ER  - 

@article{
author = "Mihajlović, Ekatarina and Biancalana, Lorenzo and Jelača, Sanja and Chiaverini, Lorenzo and Dojčinović, Biljana and Dunđerović, Duško and Zacchini, Stefano and Mijatović, Sanja and Maksimović-Ivanić, Danijela and Marchetti, Fabio",
year = "2024",
abstract = "FETPY, an organo-diiron(I) complex, showed strong cytotoxicity across a panel of human and mouse cancer cell lines, combined with an outstanding selectivity compared to nonmalignant cells. Enhanced iron uptake in aggressive, low-differentiated cell lines, caused membrane lipid peroxidation, which resulted in ferroptosis in human ovarian cancer cells. FETPY induced significant morphological changes in murine B16–F1 and B16–F10 melanoma cells, leading to senescence and/or trans-differentiation into Schwann-like cells, thus significantly reducing their tumorigenic potential. Additionally, FETPY substantially suppressed tumor growth in low- and high-grade syngeneic melanoma models when administered in a therapeutic regimen. FETPY is featured by satisfactory water solubility (millimolar range), an amphiphilic character (Log Pow = −0.17), and excellent stability in a biological medium (DMEM). These important requisites for drug development are rarely met in iron complexes investigated so far as possible anticancer agents. Overall, FETPY holds promise as a safe and potent targeted antitumor agent.",
publisher = "American Chemical Society",
journal = "Journal of Medicinal Chemistry",
title = "FETPY: a Diiron(I) Thio–Carbyne Complex with Prominent Anticancer Activity In Vitro and In Vivo",
number = "9",
volume = "67",
doi = "10.1021/acs.jmedchem.4c00377",
pages = "7553-7568"
}

Mihajlović, E., Biancalana, L., Jelača, S., Chiaverini, L., Dojčinović, B., Dunđerović, D., Zacchini, S., Mijatović, S., Maksimović-Ivanić, D.,& Marchetti, F.. (2024). FETPY: a Diiron(I) Thio–Carbyne Complex with Prominent Anticancer Activity In Vitro and In Vivo. in Journal of Medicinal Chemistry
American Chemical Society., 67(9), 7553-7568.
https://doi.org/10.1021/acs.jmedchem.4c00377

Mihajlović E, Biancalana L, Jelača S, Chiaverini L, Dojčinović B, Dunđerović D, Zacchini S, Mijatović S, Maksimović-Ivanić D, Marchetti F. FETPY: a Diiron(I) Thio–Carbyne Complex with Prominent Anticancer Activity In Vitro and In Vivo. in Journal of Medicinal Chemistry. 2024;67(9):7553-7568.
doi:10.1021/acs.jmedchem.4c00377 .

Mihajlović, Ekatarina, Biancalana, Lorenzo, Jelača, Sanja, Chiaverini, Lorenzo, Dojčinović, Biljana, Dunđerović, Duško, Zacchini, Stefano, Mijatović, Sanja, Maksimović-Ivanić, Danijela, Marchetti, Fabio, "FETPY: a Diiron(I) Thio–Carbyne Complex with Prominent Anticancer Activity In Vitro and In Vivo" in Journal of Medicinal Chemistry, 67, no. 9 (2024):7553-7568,
https://doi.org/10.1021/acs.jmedchem.4c00377 . .

TY  - JOUR
AU  - Fotirić Akšić, Milica
AU  - Tešić, Živoslav
AU  - Kalaba, Milica
AU  - Ćirić, Ivanka
AU  - Pezo, Lato
AU  - Lončar, Biljana
AU  - Gašić, Uroš
AU  - Dojčinović, Biljana
AU  - Tosti, Tomislav
AU  - Meland, Mekjell
PY  - 2023
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6467
AB  - The aim of this study was to find the chemical parameters for the differentiation of plum cultivars grown along the fjord areas of Western Norway and Eastern Norway, having specific agroclimatic conditions. Chemical analysis of the fruits confirmed the contents of 13 quantified elements, 22 sugar compounds, 11 organic acids, 19 phenolic compounds, and antioxidant activity in 68 plum cultivars. Dominated contents were noted for nitrogen (with the maximum mean value of 3.11%), potassium (8055.80 mg/kg), and phosphorous (7878.88 mg/kg). Averagely, the highest level of sugars was determined for glucose (244.46 g/kg), fructose (197.92 g/kg), sucrose (208.25 g/kg), and sorbitol (98.02 g/kg), organic acids for malic acid (24.06 g/kg), and for polyphenol compounds were 5-O-caffeoylquinic acid (66.31 mg/kg), and rutin (58.06 mg/kg). Applied principal component analysis has been useful for distinguishing the plum cultivars from three areas in Norway where copper, iron, potassium, magnesium, manganese, and sodium; sucrose, ribose, maltose, and raffinose; p-hydroxybenzoic acid, rutin, ferulic acid, kaempferol 7-O-glucoside, p-coumaric acid, and 5-O-caffeoylquinic acid were the most influential. In regard to human health and future breeding work that will have the aim to produce functional food with high health-related compounds, the plum cultivar ‘Mallard’ should be underlined due to the high level of elements, ‘Valor’ due to high sugar content, ‘Helgøyplomme’ due to content of organic acids, and ‘Diamond’ due to the content of phenolic compounds.
PB  - Basel: MDPI
T2  - Horticulturae
T1  - Breakthrough Analysis of Chemical Composition and Applied Chemometrics of European Plum Cultivars Grown in Norway
IS  - 4
VL  - 9
DO  - 10.3390/horticulturae9040477
SP  - 477
ER  - 

@article{
author = "Fotirić Akšić, Milica and Tešić, Živoslav and Kalaba, Milica and Ćirić, Ivanka and Pezo, Lato and Lončar, Biljana and Gašić, Uroš and Dojčinović, Biljana and Tosti, Tomislav and Meland, Mekjell",
year = "2023",
abstract = "The aim of this study was to find the chemical parameters for the differentiation of plum cultivars grown along the fjord areas of Western Norway and Eastern Norway, having specific agroclimatic conditions. Chemical analysis of the fruits confirmed the contents of 13 quantified elements, 22 sugar compounds, 11 organic acids, 19 phenolic compounds, and antioxidant activity in 68 plum cultivars. Dominated contents were noted for nitrogen (with the maximum mean value of 3.11%), potassium (8055.80 mg/kg), and phosphorous (7878.88 mg/kg). Averagely, the highest level of sugars was determined for glucose (244.46 g/kg), fructose (197.92 g/kg), sucrose (208.25 g/kg), and sorbitol (98.02 g/kg), organic acids for malic acid (24.06 g/kg), and for polyphenol compounds were 5-O-caffeoylquinic acid (66.31 mg/kg), and rutin (58.06 mg/kg). Applied principal component analysis has been useful for distinguishing the plum cultivars from three areas in Norway where copper, iron, potassium, magnesium, manganese, and sodium; sucrose, ribose, maltose, and raffinose; p-hydroxybenzoic acid, rutin, ferulic acid, kaempferol 7-O-glucoside, p-coumaric acid, and 5-O-caffeoylquinic acid were the most influential. In regard to human health and future breeding work that will have the aim to produce functional food with high health-related compounds, the plum cultivar ‘Mallard’ should be underlined due to the high level of elements, ‘Valor’ due to high sugar content, ‘Helgøyplomme’ due to content of organic acids, and ‘Diamond’ due to the content of phenolic compounds.",
publisher = "Basel: MDPI",
journal = "Horticulturae",
title = "Breakthrough Analysis of Chemical Composition and Applied Chemometrics of European Plum Cultivars Grown in Norway",
number = "4",
volume = "9",
doi = "10.3390/horticulturae9040477",
pages = "477"
}

Fotirić Akšić, M., Tešić, Ž., Kalaba, M., Ćirić, I., Pezo, L., Lončar, B., Gašić, U., Dojčinović, B., Tosti, T.,& Meland, M.. (2023). Breakthrough Analysis of Chemical Composition and Applied Chemometrics of European Plum Cultivars Grown in Norway. in Horticulturae
Basel: MDPI., 9(4), 477.
https://doi.org/10.3390/horticulturae9040477

Fotirić Akšić M, Tešić Ž, Kalaba M, Ćirić I, Pezo L, Lončar B, Gašić U, Dojčinović B, Tosti T, Meland M. Breakthrough Analysis of Chemical Composition and Applied Chemometrics of European Plum Cultivars Grown in Norway. in Horticulturae. 2023;9(4):477.
doi:10.3390/horticulturae9040477 .

Fotirić Akšić, Milica, Tešić, Živoslav, Kalaba, Milica, Ćirić, Ivanka, Pezo, Lato, Lončar, Biljana, Gašić, Uroš, Dojčinović, Biljana, Tosti, Tomislav, Meland, Mekjell, "Breakthrough Analysis of Chemical Composition and Applied Chemometrics of European Plum Cultivars Grown in Norway" in Horticulturae, 9, no. 4 (2023):477,
https://doi.org/10.3390/horticulturae9040477 . .

TY  - CONF
AU  - Mihajlović, Ekatarina
AU  - Jelača, Sanja
AU  - Biancalana, Lorenzo
AU  - Chiaverini, Lorenzo
AU  - Dojčinović, Biljana
AU  - Mijatović, Sanja
AU  - Zacchini, Stefano
AU  - Marchetti, Fabio
AU  - Maksimović-Ivanić, Danijela
PY  - 2023
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6216
AB  - To improve safety and efficacy of conventional chemotherapeutics, it is important to target
cancer cells more selectively. Potential strategies could arise from differences in iron
metabolism between healthy and cancer cells, based on cancer cells high demands for iron.
Their, so-called, “iron addiction” sets a foundation for new therapeutic approach. In this
study, the cytotoxic effect of three diiron carbonyl complexes with a bridging thiocarbyne
ligand was evaluated on different human cancer cell lines (HCT116 colorectal carcinoma,
MCF-7 breast cancer and A2780 ovarian cancer), as well as on human embryonic lung
fibroblasts (MRC-5), which were used for selectivity assessment. The most potent
compound (FETPY) decreased viability of all cancer cell lines in dose-dependent manner,
while A2780 cells emerged as the most sensitive. Therefore, they were selected for further
investigation. On the other hand, the effect of FETPY on lung fibroblasts viability was
remarkably less potent, showing its great selectivity towards malignant phenotype.
Additionally, it was shown that intracellular iron concentration was much higher in A2780
than in MRC-5 cells after treatment with FETPY. Viability decrease of A2780 cells was a
consequence of cell death – ferroptosis, caused by iron-dependent lipid peroxidation and
membrane damage. Oxidative stress that caused ferroptosis evolved from intensive
production of nitric oxide and superoxide anion. Controversially, it was followed with
scavenging of hydrogen peroxide and peroxynitrite. Treatment with FETPY also caused
significant decrease of A2780 cells division rate. Overall, these results indicate that the
considered diiron derivatives show great potential for further investigation in cancer
treatment.
PB  - Belgrade: Faculty of Chemistry
C3  - Biochemistry in Biotechnology: Serbian Biochemical Society, Twelfth Conference, International scientific meeting; 2023 Sep 21-23; Belgrade, Serbia
T1  - Anticancer potential of diiron thiocarbyne complexes
SP  - 68
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_6216
ER  - 

@conference{
author = "Mihajlović, Ekatarina and Jelača, Sanja and Biancalana, Lorenzo and Chiaverini, Lorenzo and Dojčinović, Biljana and Mijatović, Sanja and Zacchini, Stefano and Marchetti, Fabio and Maksimović-Ivanić, Danijela",
year = "2023",
abstract = "To improve safety and efficacy of conventional chemotherapeutics, it is important to target
cancer cells more selectively. Potential strategies could arise from differences in iron
metabolism between healthy and cancer cells, based on cancer cells high demands for iron.
Their, so-called, “iron addiction” sets a foundation for new therapeutic approach. In this
study, the cytotoxic effect of three diiron carbonyl complexes with a bridging thiocarbyne
ligand was evaluated on different human cancer cell lines (HCT116 colorectal carcinoma,
MCF-7 breast cancer and A2780 ovarian cancer), as well as on human embryonic lung
fibroblasts (MRC-5), which were used for selectivity assessment. The most potent
compound (FETPY) decreased viability of all cancer cell lines in dose-dependent manner,
while A2780 cells emerged as the most sensitive. Therefore, they were selected for further
investigation. On the other hand, the effect of FETPY on lung fibroblasts viability was
remarkably less potent, showing its great selectivity towards malignant phenotype.
Additionally, it was shown that intracellular iron concentration was much higher in A2780
than in MRC-5 cells after treatment with FETPY. Viability decrease of A2780 cells was a
consequence of cell death – ferroptosis, caused by iron-dependent lipid peroxidation and
membrane damage. Oxidative stress that caused ferroptosis evolved from intensive
production of nitric oxide and superoxide anion. Controversially, it was followed with
scavenging of hydrogen peroxide and peroxynitrite. Treatment with FETPY also caused
significant decrease of A2780 cells division rate. Overall, these results indicate that the
considered diiron derivatives show great potential for further investigation in cancer
treatment.",
publisher = "Belgrade: Faculty of Chemistry",
journal = "Biochemistry in Biotechnology: Serbian Biochemical Society, Twelfth Conference, International scientific meeting; 2023 Sep 21-23; Belgrade, Serbia",
title = "Anticancer potential of diiron thiocarbyne complexes",
pages = "68",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_6216"
}

Mihajlović, E., Jelača, S., Biancalana, L., Chiaverini, L., Dojčinović, B., Mijatović, S., Zacchini, S., Marchetti, F.,& Maksimović-Ivanić, D.. (2023). Anticancer potential of diiron thiocarbyne complexes. in Biochemistry in Biotechnology: Serbian Biochemical Society, Twelfth Conference, International scientific meeting; 2023 Sep 21-23; Belgrade, Serbia
Belgrade: Faculty of Chemistry., 68.
https://hdl.handle.net/21.15107/rcub_ibiss_6216

Mihajlović E, Jelača S, Biancalana L, Chiaverini L, Dojčinović B, Mijatović S, Zacchini S, Marchetti F, Maksimović-Ivanić D. Anticancer potential of diiron thiocarbyne complexes. in Biochemistry in Biotechnology: Serbian Biochemical Society, Twelfth Conference, International scientific meeting; 2023 Sep 21-23; Belgrade, Serbia. 2023;:68.
https://hdl.handle.net/21.15107/rcub_ibiss_6216 .

Mihajlović, Ekatarina, Jelača, Sanja, Biancalana, Lorenzo, Chiaverini, Lorenzo, Dojčinović, Biljana, Mijatović, Sanja, Zacchini, Stefano, Marchetti, Fabio, Maksimović-Ivanić, Danijela, "Anticancer potential of diiron thiocarbyne complexes" in Biochemistry in Biotechnology: Serbian Biochemical Society, Twelfth Conference, International scientific meeting; 2023 Sep 21-23; Belgrade, Serbia (2023):68,
https://hdl.handle.net/21.15107/rcub_ibiss_6216 .

TY  - JOUR
AU  - Fotirić Akšić, Milica
AU  - Nešović, Milica
AU  - Ćirić, Ivanka
AU  - Tešić, Živoslav
AU  - Pezo, Lato
AU  - Tosti, Tomislav
AU  - Gašić, Uroš
AU  - Dojčinović, Biljana
AU  - Lončar, Biljana
AU  - Meland, Mekjell
PY  - 2022
UR  - https://www.mdpi.com/2311-7524/8/9/765
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5130
AB  - Raspberries are considered valuable fruits due to their high levels of nutrients and phytochemicals, which have many beneficial effects on humans. As many external factors affect the composition of these fruits (the type of cultivation, soil characteristics, ripeness, storage time and post-harvest technologies, cultivar/genotype, and climatic conditions), the goal of this study was to analyze different raspberry cultivars grown in Norway. Considering that Norway is a country with specific climatic conditions, as well as has a limited period of fruit vegetation, another important goal of this study was also to compare raspberries from different Norwegian areas, as well as different grown cultivars. Modern analytical techniques, such as high-performance anion-exchange liquid chromatography with pulsed amperometric detection (HPEAC-PAD), ultra-high-performance liquid chromatography with diode array detector coupled to triple quadrupole mass spectrometry (UHPLC-DAD MS/MS), and inductively coupled plasma–optical emission spectrometry (ICP-OES), provided a detailed examination of the raspberry extract samples. Based on their high levels of minerals (especially N, P, and K), organic acids (predominantly citric and malic acids), sugars (glucose, fructose, sucrose, and galactose), and polyphenols (ellagic acid, syringic acid, quercetin, and rutin), Norwegian raspberries could be considered fruits with increased health-beneficial compounds. The chemical composition of the studied cultivars depended on the locality of growth.
PB  - Basel: MDPI
T2  - Horticulturae
T1  - Chemical Fruit Profiles of Different Raspberry Cultivars Grown in Specific Norwegian Agroclimatic Conditions
IS  - 9
VL  - 8
DO  - 10.3390/horticulturae8090765
SP  - 765
ER  - 

@article{
author = "Fotirić Akšić, Milica and Nešović, Milica and Ćirić, Ivanka and Tešić, Živoslav and Pezo, Lato and Tosti, Tomislav and Gašić, Uroš and Dojčinović, Biljana and Lončar, Biljana and Meland, Mekjell",
year = "2022",
abstract = "Raspberries are considered valuable fruits due to their high levels of nutrients and phytochemicals, which have many beneficial effects on humans. As many external factors affect the composition of these fruits (the type of cultivation, soil characteristics, ripeness, storage time and post-harvest technologies, cultivar/genotype, and climatic conditions), the goal of this study was to analyze different raspberry cultivars grown in Norway. Considering that Norway is a country with specific climatic conditions, as well as has a limited period of fruit vegetation, another important goal of this study was also to compare raspberries from different Norwegian areas, as well as different grown cultivars. Modern analytical techniques, such as high-performance anion-exchange liquid chromatography with pulsed amperometric detection (HPEAC-PAD), ultra-high-performance liquid chromatography with diode array detector coupled to triple quadrupole mass spectrometry (UHPLC-DAD MS/MS), and inductively coupled plasma–optical emission spectrometry (ICP-OES), provided a detailed examination of the raspberry extract samples. Based on their high levels of minerals (especially N, P, and K), organic acids (predominantly citric and malic acids), sugars (glucose, fructose, sucrose, and galactose), and polyphenols (ellagic acid, syringic acid, quercetin, and rutin), Norwegian raspberries could be considered fruits with increased health-beneficial compounds. The chemical composition of the studied cultivars depended on the locality of growth.",
publisher = "Basel: MDPI",
journal = "Horticulturae",
title = "Chemical Fruit Profiles of Different Raspberry Cultivars Grown in Specific Norwegian Agroclimatic Conditions",
number = "9",
volume = "8",
doi = "10.3390/horticulturae8090765",
pages = "765"
}

Fotirić Akšić, M., Nešović, M., Ćirić, I., Tešić, Ž., Pezo, L., Tosti, T., Gašić, U., Dojčinović, B., Lončar, B.,& Meland, M.. (2022). Chemical Fruit Profiles of Different Raspberry Cultivars Grown in Specific Norwegian Agroclimatic Conditions. in Horticulturae
Basel: MDPI., 8(9), 765.
https://doi.org/10.3390/horticulturae8090765

Fotirić Akšić M, Nešović M, Ćirić I, Tešić Ž, Pezo L, Tosti T, Gašić U, Dojčinović B, Lončar B, Meland M. Chemical Fruit Profiles of Different Raspberry Cultivars Grown in Specific Norwegian Agroclimatic Conditions. in Horticulturae. 2022;8(9):765.
doi:10.3390/horticulturae8090765 .

Fotirić Akšić, Milica, Nešović, Milica, Ćirić, Ivanka, Tešić, Živoslav, Pezo, Lato, Tosti, Tomislav, Gašić, Uroš, Dojčinović, Biljana, Lončar, Biljana, Meland, Mekjell, "Chemical Fruit Profiles of Different Raspberry Cultivars Grown in Specific Norwegian Agroclimatic Conditions" in Horticulturae, 8, no. 9 (2022):765,
https://doi.org/10.3390/horticulturae8090765 . .

TY  - JOUR
AU  - Fotirić Akšić, Milica
AU  - Nešović, Milica
AU  - Ćirić, Ivanka
AU  - Tešić, Živoslav
AU  - Pezo, Lato
AU  - Tosti, Tomislav
AU  - Gašić, Uroš
AU  - Dojčinović, Biljana
AU  - Lončar, Biljana
AU  - Meland, Mekjell
PY  - 2022
UR  - https://www.frontiersin.org/articles/10.3389/fnut.2022.941487/full
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5081
AB  - Using modern analytical techniques, a comprehensive study of the chemical composition of fruits from apple cultivars grown in Western Norway during 2019 and 2020 was done. Metals, sugars, organic acids, antioxidant tests, and polyphenol content have been observed. In all investigated samples, the most dominant sugars were glucose, fructose, and sucrose. Among 11 tested organic acids, the dominant was malic acid, followed by citric and maleic acid. The most common metal was potassium, followed by magnesium and zinc. The quantification of polyphenols showed that among the 11 quantified polyphenols, chlorogenic acid, quercetin 3- O- rhamnoside, quercetin 3 -O -glucoside, quercetin, and phlorizin were the most abundant. A detailed study of the polyphenolic profile of nine investigated apple samples provided 30 identified polyphenolic compounds from the class of hydroxybenzoic and hydroxycinnamic acids, flavonoids, and dihydrochalcones. In addition to the identified 3- O -caffeoylquinic acid, its two isomers of 5- O -caffeoylquinic acid and three esters were also found. Present polyphenols of the tested apples provided significant data on the quality of Norwegian apples, and they contribute to the distinguishing of these apple samples.
PB  - Lausanne: Frontiers Media S.A.
T2  - Frontiers in Nutrition
T1  - Polyphenolics and Chemical Profiles of Domestic Norwegian Apple (Malus × domestica Borkh.) Cultivars
VL  - 9
DO  - 10.3389/fnut.2022.941487
SP  - 941487
ER  - 

@article{
author = "Fotirić Akšić, Milica and Nešović, Milica and Ćirić, Ivanka and Tešić, Živoslav and Pezo, Lato and Tosti, Tomislav and Gašić, Uroš and Dojčinović, Biljana and Lončar, Biljana and Meland, Mekjell",
year = "2022",
abstract = "Using modern analytical techniques, a comprehensive study of the chemical composition of fruits from apple cultivars grown in Western Norway during 2019 and 2020 was done. Metals, sugars, organic acids, antioxidant tests, and polyphenol content have been observed. In all investigated samples, the most dominant sugars were glucose, fructose, and sucrose. Among 11 tested organic acids, the dominant was malic acid, followed by citric and maleic acid. The most common metal was potassium, followed by magnesium and zinc. The quantification of polyphenols showed that among the 11 quantified polyphenols, chlorogenic acid, quercetin 3- O- rhamnoside, quercetin 3 -O -glucoside, quercetin, and phlorizin were the most abundant. A detailed study of the polyphenolic profile of nine investigated apple samples provided 30 identified polyphenolic compounds from the class of hydroxybenzoic and hydroxycinnamic acids, flavonoids, and dihydrochalcones. In addition to the identified 3- O -caffeoylquinic acid, its two isomers of 5- O -caffeoylquinic acid and three esters were also found. Present polyphenols of the tested apples provided significant data on the quality of Norwegian apples, and they contribute to the distinguishing of these apple samples.",
publisher = "Lausanne: Frontiers Media S.A.",
journal = "Frontiers in Nutrition",
title = "Polyphenolics and Chemical Profiles of Domestic Norwegian Apple (Malus × domestica Borkh.) Cultivars",
volume = "9",
doi = "10.3389/fnut.2022.941487",
pages = "941487"
}

Fotirić Akšić, M., Nešović, M., Ćirić, I., Tešić, Ž., Pezo, L., Tosti, T., Gašić, U., Dojčinović, B., Lončar, B.,& Meland, M.. (2022). Polyphenolics and Chemical Profiles of Domestic Norwegian Apple (Malus × domestica Borkh.) Cultivars. in Frontiers in Nutrition
Lausanne: Frontiers Media S.A.., 9, 941487.
https://doi.org/10.3389/fnut.2022.941487

Fotirić Akšić M, Nešović M, Ćirić I, Tešić Ž, Pezo L, Tosti T, Gašić U, Dojčinović B, Lončar B, Meland M. Polyphenolics and Chemical Profiles of Domestic Norwegian Apple (Malus × domestica Borkh.) Cultivars. in Frontiers in Nutrition. 2022;9:941487.
doi:10.3389/fnut.2022.941487 .

Fotirić Akšić, Milica, Nešović, Milica, Ćirić, Ivanka, Tešić, Živoslav, Pezo, Lato, Tosti, Tomislav, Gašić, Uroš, Dojčinović, Biljana, Lončar, Biljana, Meland, Mekjell, "Polyphenolics and Chemical Profiles of Domestic Norwegian Apple (Malus × domestica Borkh.) Cultivars" in Frontiers in Nutrition, 9 (2022):941487,
https://doi.org/10.3389/fnut.2022.941487 . .

TY  - JOUR
AU  - Natić, Maja
AU  - Dabić Zagorac, Dragana
AU  - Gašić, Uroš
AU  - Dojčinović, Biljana
AU  - Ćirić, Ivanka
AU  - Relić, Dubravka
AU  - Todić, Slavica
AU  - Sredojević, Milica
PY  - 2021
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4138
AB  - The phenolic and elemental profiles of Serbian autochthonous grape varieties ‘Smederevka’ and ‘Plovdina’ were studied and compared with some international varieties. Total phenolic content and radical scavenging activity were highest in seeds of ‘Plovdina’, and in ‘Smederevka’ skins, which also had the highest contents of ferulic, chlorogenic and caffeic acids (16.0, 1.44 and 0.98 mg/kg, respectively). Protocatechuic acid was quantified only in the seeds of these varieties. Untypically for Vitis vinifera L. species, the presence of malvidin 3,5-O-dihexoside was found in the skins of ‘Vranac’ and ‘Muscat Hamburg’. In ‘Plovdina’ skins among the anthocyanins, hexosides of peonidin and delphinidin were prevalent. ‘Plovdina’ grapes had lower quantities of Al, Ni and Na in comparison to the other varieties intended for white wine production. Significant correlations among the most abundant elements, such as K, P, Ca, Mg, S, Fe, Cu, and Zn, pointed to potential positive interactions. For elements that have toxicological reference values, the health risk assessment was calculated for adults and children, and suggested that all samples were safe for human consumption.
PB  - Elsevier Ltd
T2  - Food Bioscience
T1  - Autochthonous and international grape varieties grown in Serbia - Phenolic and elemental composition
VL  - 40
DO  - 10.1016/j.fbio.2021.100889
SP  - 100889
ER  - 

@article{
author = "Natić, Maja and Dabić Zagorac, Dragana and Gašić, Uroš and Dojčinović, Biljana and Ćirić, Ivanka and Relić, Dubravka and Todić, Slavica and Sredojević, Milica",
year = "2021",
abstract = "The phenolic and elemental profiles of Serbian autochthonous grape varieties ‘Smederevka’ and ‘Plovdina’ were studied and compared with some international varieties. Total phenolic content and radical scavenging activity were highest in seeds of ‘Plovdina’, and in ‘Smederevka’ skins, which also had the highest contents of ferulic, chlorogenic and caffeic acids (16.0, 1.44 and 0.98 mg/kg, respectively). Protocatechuic acid was quantified only in the seeds of these varieties. Untypically for Vitis vinifera L. species, the presence of malvidin 3,5-O-dihexoside was found in the skins of ‘Vranac’ and ‘Muscat Hamburg’. In ‘Plovdina’ skins among the anthocyanins, hexosides of peonidin and delphinidin were prevalent. ‘Plovdina’ grapes had lower quantities of Al, Ni and Na in comparison to the other varieties intended for white wine production. Significant correlations among the most abundant elements, such as K, P, Ca, Mg, S, Fe, Cu, and Zn, pointed to potential positive interactions. For elements that have toxicological reference values, the health risk assessment was calculated for adults and children, and suggested that all samples were safe for human consumption.",
publisher = "Elsevier Ltd",
journal = "Food Bioscience",
title = "Autochthonous and international grape varieties grown in Serbia - Phenolic and elemental composition",
volume = "40",
doi = "10.1016/j.fbio.2021.100889",
pages = "100889"
}

Natić, M., Dabić Zagorac, D., Gašić, U., Dojčinović, B., Ćirić, I., Relić, D., Todić, S.,& Sredojević, M.. (2021). Autochthonous and international grape varieties grown in Serbia - Phenolic and elemental composition. in Food Bioscience
Elsevier Ltd., 40, 100889.
https://doi.org/10.1016/j.fbio.2021.100889

Natić M, Dabić Zagorac D, Gašić U, Dojčinović B, Ćirić I, Relić D, Todić S, Sredojević M. Autochthonous and international grape varieties grown in Serbia - Phenolic and elemental composition. in Food Bioscience. 2021;40:100889.
doi:10.1016/j.fbio.2021.100889 .

Natić, Maja, Dabić Zagorac, Dragana, Gašić, Uroš, Dojčinović, Biljana, Ćirić, Ivanka, Relić, Dubravka, Todić, Slavica, Sredojević, Milica, "Autochthonous and international grape varieties grown in Serbia - Phenolic and elemental composition" in Food Bioscience, 40 (2021):100889,
https://doi.org/10.1016/j.fbio.2021.100889 . .

TY  - JOUR
AU  - Drača, Dijana
AU  - Edeler, David
AU  - Saoud, Mohamad
AU  - Dojčinović, Biljana
AU  - Dunđerović, Duško
AU  - Đmura, Goran
AU  - Maksimović-Ivanić, Danijela
AU  - Mijatović, Sanja
AU  - Kaluđerović, Goran N.
PY  - 2021
UR  - internal-pdf://Drača et al. - 2021 - Antitumor potential of cisplatin loaded into SBA-15 mesoporous silica nanoparticles against B16F1 melanoma cells i.pdf
UR  - https://linkinghub.elsevier.com/retrieve/pii/S0162013421000301
UR  - http://www.ncbi.nlm.nih.gov/pubmed/33582397
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4154
AB  - CP (cisplatin) and mesoporous silica SBA-15 (Santa Barbara amorphous 15) loaded with CP (→SBA-15|CP) were tested in vitro and in vivo against low metastatic mouse melanoma B16F1 cell line. SBA-15 only, as drug carrier, is found to be not active, while CP and SBA-15|CP revealed high cytotoxicity in lower μM range. The activity of SBA-15|CP was found similar to the activity of CP alone. Both CP and SBA-15|CP induced inhibition of cell proliferation (carboxyfluorescein succinimidyl ester - CFSE assay) along with G2/M arrest (4',6-diamidino-2-phenylindole - DAPI assay). Apoptosis (Annexin V/ propidium iodide - PI assay), through caspase activation (apostat assay) and nitric oxide (NO) production (diacetate(4-amino-5-methylamino-2',7'-difluorofluorescein-diacetat) - DAF FM assay), was identified as main mode of cell death. However, slight elevated autophagy (acridine orange - AO assay) was detected in treated B16F1 cells. CP and SBA-15|CP did not affect production of ROS (reactive oxygen species) in B16F1 cells. Both SBA-15|CP and CP induced in B16F1 G2 arrest and subsequent senescence. SBA-15|CP, but not CP, blocked the growth of melanoma in C57BL/6 mice. Moreover, hepato- and nephrotoxicity in SBA-15|CP treated animals were diminished in comparison to CP confirming multiply improved antitumor potential of immobilized CP. Outstandingly, SBA-15 boosted in vivo activity and diminished side effects of CP.
PB  - Elsevier BV
T2  - Journal of Inorganic Biochemistry
T1  - Antitumor potential of cisplatin loaded into SBA-15 mesoporous silica nanoparticles against B16F1 melanoma cells: in vitro and in vivo studies.
VL  - 217
DO  - 10.1016/j.jinorgbio.2021.111383
SP  - 111383
ER  - 

@article{
author = "Drača, Dijana and Edeler, David and Saoud, Mohamad and Dojčinović, Biljana and Dunđerović, Duško and Đmura, Goran and Maksimović-Ivanić, Danijela and Mijatović, Sanja and Kaluđerović, Goran N.",
year = "2021",
abstract = "CP (cisplatin) and mesoporous silica SBA-15 (Santa Barbara amorphous 15) loaded with CP (→SBA-15|CP) were tested in vitro and in vivo against low metastatic mouse melanoma B16F1 cell line. SBA-15 only, as drug carrier, is found to be not active, while CP and SBA-15|CP revealed high cytotoxicity in lower μM range. The activity of SBA-15|CP was found similar to the activity of CP alone. Both CP and SBA-15|CP induced inhibition of cell proliferation (carboxyfluorescein succinimidyl ester - CFSE assay) along with G2/M arrest (4',6-diamidino-2-phenylindole - DAPI assay). Apoptosis (Annexin V/ propidium iodide - PI assay), through caspase activation (apostat assay) and nitric oxide (NO) production (diacetate(4-amino-5-methylamino-2',7'-difluorofluorescein-diacetat) - DAF FM assay), was identified as main mode of cell death. However, slight elevated autophagy (acridine orange - AO assay) was detected in treated B16F1 cells. CP and SBA-15|CP did not affect production of ROS (reactive oxygen species) in B16F1 cells. Both SBA-15|CP and CP induced in B16F1 G2 arrest and subsequent senescence. SBA-15|CP, but not CP, blocked the growth of melanoma in C57BL/6 mice. Moreover, hepato- and nephrotoxicity in SBA-15|CP treated animals were diminished in comparison to CP confirming multiply improved antitumor potential of immobilized CP. Outstandingly, SBA-15 boosted in vivo activity and diminished side effects of CP.",
publisher = "Elsevier BV",
journal = "Journal of Inorganic Biochemistry",
title = "Antitumor potential of cisplatin loaded into SBA-15 mesoporous silica nanoparticles against B16F1 melanoma cells: in vitro and in vivo studies.",
volume = "217",
doi = "10.1016/j.jinorgbio.2021.111383",
pages = "111383"
}

Drača, D., Edeler, D., Saoud, M., Dojčinović, B., Dunđerović, D., Đmura, G., Maksimović-Ivanić, D., Mijatović, S.,& Kaluđerović, G. N.. (2021). Antitumor potential of cisplatin loaded into SBA-15 mesoporous silica nanoparticles against B16F1 melanoma cells: in vitro and in vivo studies.. in Journal of Inorganic Biochemistry
Elsevier BV., 217, 111383.
https://doi.org/10.1016/j.jinorgbio.2021.111383

Drača D, Edeler D, Saoud M, Dojčinović B, Dunđerović D, Đmura G, Maksimović-Ivanić D, Mijatović S, Kaluđerović GN. Antitumor potential of cisplatin loaded into SBA-15 mesoporous silica nanoparticles against B16F1 melanoma cells: in vitro and in vivo studies.. in Journal of Inorganic Biochemistry. 2021;217:111383.
doi:10.1016/j.jinorgbio.2021.111383 .

Drača, Dijana, Edeler, David, Saoud, Mohamad, Dojčinović, Biljana, Dunđerović, Duško, Đmura, Goran, Maksimović-Ivanić, Danijela, Mijatović, Sanja, Kaluđerović, Goran N., "Antitumor potential of cisplatin loaded into SBA-15 mesoporous silica nanoparticles against B16F1 melanoma cells: in vitro and in vivo studies." in Journal of Inorganic Biochemistry, 217 (2021):111383,
https://doi.org/10.1016/j.jinorgbio.2021.111383 . .

TY  - JOUR
AU  - Radović, Mirjana
AU  - Milatović, Dragan
AU  - Tešić, Živoslav
AU  - Tosti, Tomislav
AU  - Gašić, Uroš
AU  - Dojčinović, Biljana
AU  - Dabić Zagorac, Dragana
PY  - 2020
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3705
AB  - This paper presents the chemical composition of the fruits of three European plum cultivars (‘Cacanska Rana’, ‘Cacanska Lepotica’, and ‘Cacanska Najbolja’) grafted on four rootstocks (Myrobalan, ‘Pixy’, ‘Fereley’, and ‘St. Julien A’). The rootstock/cultivar combinations significantly influenced the content of most of the phenolic compounds in the plum skin and flesh. The total anthocyanin content in the skin ranged from 1.87 to 7.33 mg cyanidin-3-glucoside g−1 fresh weight. The major phenolic compound in the skin was rutin, which ranged from 95 to 238 mg kg−1, while in the flesh, cinnamic acid and catechin were dominant. The total sugar content in the fruit ranged from 66.2–147 mg g−1. The highest glucose and fructose contents were in ‘Cacanska Lepotica’, then in ‘Cacanska Najbolja’, and the lowest were in ‘Cacanska Rana’ cultivar. The highest contents of glucose and sucrose were found in fruits from trees grafted on Myrobalan rootstock, and the lowest in fruits from trees grafted on ‘St. Julien A’ rootstock. The rootstocks significantly influenced the potassium, calcium, and copper contents in the plum fruit. The results of this study demonstrate the significant effect of rootstocks on the phenolic and sugar profiles, and on the mineral content of the plum fruits.
PB  - Academic Press Inc.
T2  - Journal of Food Composition and Analysis
T1  - Influence of rootstocks on the chemical composition of the fruits of plum cultivars
VL  - 92
DO  - 10.1016/j.jfca.2020.103480
SP  - 103480
ER  - 

@article{
author = "Radović, Mirjana and Milatović, Dragan and Tešić, Živoslav and Tosti, Tomislav and Gašić, Uroš and Dojčinović, Biljana and Dabić Zagorac, Dragana",
year = "2020",
abstract = "This paper presents the chemical composition of the fruits of three European plum cultivars (‘Cacanska Rana’, ‘Cacanska Lepotica’, and ‘Cacanska Najbolja’) grafted on four rootstocks (Myrobalan, ‘Pixy’, ‘Fereley’, and ‘St. Julien A’). The rootstock/cultivar combinations significantly influenced the content of most of the phenolic compounds in the plum skin and flesh. The total anthocyanin content in the skin ranged from 1.87 to 7.33 mg cyanidin-3-glucoside g−1 fresh weight. The major phenolic compound in the skin was rutin, which ranged from 95 to 238 mg kg−1, while in the flesh, cinnamic acid and catechin were dominant. The total sugar content in the fruit ranged from 66.2–147 mg g−1. The highest glucose and fructose contents were in ‘Cacanska Lepotica’, then in ‘Cacanska Najbolja’, and the lowest were in ‘Cacanska Rana’ cultivar. The highest contents of glucose and sucrose were found in fruits from trees grafted on Myrobalan rootstock, and the lowest in fruits from trees grafted on ‘St. Julien A’ rootstock. The rootstocks significantly influenced the potassium, calcium, and copper contents in the plum fruit. The results of this study demonstrate the significant effect of rootstocks on the phenolic and sugar profiles, and on the mineral content of the plum fruits.",
publisher = "Academic Press Inc.",
journal = "Journal of Food Composition and Analysis",
title = "Influence of rootstocks on the chemical composition of the fruits of plum cultivars",
volume = "92",
doi = "10.1016/j.jfca.2020.103480",
pages = "103480"
}

Radović, M., Milatović, D., Tešić, Ž., Tosti, T., Gašić, U., Dojčinović, B.,& Dabić Zagorac, D.. (2020). Influence of rootstocks on the chemical composition of the fruits of plum cultivars. in Journal of Food Composition and Analysis
Academic Press Inc.., 92, 103480.
https://doi.org/10.1016/j.jfca.2020.103480

Radović M, Milatović D, Tešić Ž, Tosti T, Gašić U, Dojčinović B, Dabić Zagorac D. Influence of rootstocks on the chemical composition of the fruits of plum cultivars. in Journal of Food Composition and Analysis. 2020;92:103480.
doi:10.1016/j.jfca.2020.103480 .

Radović, Mirjana, Milatović, Dragan, Tešić, Živoslav, Tosti, Tomislav, Gašić, Uroš, Dojčinović, Biljana, Dabić Zagorac, Dragana, "Influence of rootstocks on the chemical composition of the fruits of plum cultivars" in Journal of Food Composition and Analysis, 92 (2020):103480,
https://doi.org/10.1016/j.jfca.2020.103480 . .

TY  - JOUR
AU  - Egerić, Marija
AU  - Smičiklas, Ivana
AU  - Dojčinović, Biljana
AU  - Sikirić, Biljana
AU  - Jović, Mihajlo
AU  - Šljivić-Ivanović, Marija
AU  - Čakmak, Dragan
PY  - 2019
UR  - https://www.sciencedirect.com/science/article/pii/S0016706119306172?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3391
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3403
AB  - Liming is a common practice in the treatment of acidic and metal contaminated soils, aiming at pH regulation, enhancing of the nutrient availability and attenuation of trace metals mobility. Replacement of natural limestone with alternative soil alkalizers found among waste materials represents a step towards sustainable resource management and reduced waste storage. In this study, waste seashells (SW) and red mud (RM) were applied in different doses to the soil sampled in the vicinity of mining and smelting complex. The soil was characterized by acidic reaction (pH 4.93), increased Cu concentration (219.2 mg/kg) and a very low level of P-supply (3.61 mg P2O5/100 g). The study aimed to quantify and compare additive-induced effects onto soil physicochemical properties, the status of macronutrients and distribution of trace metals. Targeted effect on soil pH was achieved with SW dose of 0.3% and RM dose of 2%. RM was found to be a source of available P and gave rise to the available P concentrations in the soil. Medium level of P-supply (15.60 mg P2O5/100 g) was achieved with RM dose of 5%, however, the increase in soil salinity and total trace elements concentrations have become significant adverse effects at such dose. The decrease in the ion-exchangeable content of Cu and other trace metals was in correlation with the increase in soil pH after the treatments. Redistribution of metal cations was mainly directed to carbonate/acid soluble and Fe, Mn-oxide bonded fraction after SW addition. Even though trace metals concentration has increased in the soil after application of the RM, they were principally found in the residual fraction. The results emphasize low amounts of contained trace elements and lower doses for achieving targeted effects on pH and metal mobility as the main benefits of SW treatments. On the other hand, moderate and controlled use of RM may represent multiple benefits in terms of simultaneous pH regulation, P-supply, and reduced trace metals mobility.
T2  - Geoderma
T1  - Interactions of acidic soil near copper mining and smelting complex and waste-derived alkaline additives
DO  - 10.1016/J.GEODERMA.2019.06.015
ER  - 

@article{
author = "Egerić, Marija and Smičiklas, Ivana and Dojčinović, Biljana and Sikirić, Biljana and Jović, Mihajlo and Šljivić-Ivanović, Marija and Čakmak, Dragan",
year = "2019",
abstract = "Liming is a common practice in the treatment of acidic and metal contaminated soils, aiming at pH regulation, enhancing of the nutrient availability and attenuation of trace metals mobility. Replacement of natural limestone with alternative soil alkalizers found among waste materials represents a step towards sustainable resource management and reduced waste storage. In this study, waste seashells (SW) and red mud (RM) were applied in different doses to the soil sampled in the vicinity of mining and smelting complex. The soil was characterized by acidic reaction (pH 4.93), increased Cu concentration (219.2 mg/kg) and a very low level of P-supply (3.61 mg P2O5/100 g). The study aimed to quantify and compare additive-induced effects onto soil physicochemical properties, the status of macronutrients and distribution of trace metals. Targeted effect on soil pH was achieved with SW dose of 0.3% and RM dose of 2%. RM was found to be a source of available P and gave rise to the available P concentrations in the soil. Medium level of P-supply (15.60 mg P2O5/100 g) was achieved with RM dose of 5%, however, the increase in soil salinity and total trace elements concentrations have become significant adverse effects at such dose. The decrease in the ion-exchangeable content of Cu and other trace metals was in correlation with the increase in soil pH after the treatments. Redistribution of metal cations was mainly directed to carbonate/acid soluble and Fe, Mn-oxide bonded fraction after SW addition. Even though trace metals concentration has increased in the soil after application of the RM, they were principally found in the residual fraction. The results emphasize low amounts of contained trace elements and lower doses for achieving targeted effects on pH and metal mobility as the main benefits of SW treatments. On the other hand, moderate and controlled use of RM may represent multiple benefits in terms of simultaneous pH regulation, P-supply, and reduced trace metals mobility.",
journal = "Geoderma",
title = "Interactions of acidic soil near copper mining and smelting complex and waste-derived alkaline additives",
doi = "10.1016/J.GEODERMA.2019.06.015"
}

Egerić, M., Smičiklas, I., Dojčinović, B., Sikirić, B., Jović, M., Šljivić-Ivanović, M.,& Čakmak, D.. (2019). Interactions of acidic soil near copper mining and smelting complex and waste-derived alkaline additives. in Geoderma.
https://doi.org/10.1016/J.GEODERMA.2019.06.015

Egerić M, Smičiklas I, Dojčinović B, Sikirić B, Jović M, Šljivić-Ivanović M, Čakmak D. Interactions of acidic soil near copper mining and smelting complex and waste-derived alkaline additives. in Geoderma. 2019;.
doi:10.1016/J.GEODERMA.2019.06.015 .

Egerić, Marija, Smičiklas, Ivana, Dojčinović, Biljana, Sikirić, Biljana, Jović, Mihajlo, Šljivić-Ivanović, Marija, Čakmak, Dragan, "Interactions of acidic soil near copper mining and smelting complex and waste-derived alkaline additives" in Geoderma (2019),
https://doi.org/10.1016/J.GEODERMA.2019.06.015 . .

TY  - JOUR
AU  - Egerić, Marija
AU  - Smičiklas, Ivana
AU  - Dojčinović, Biljana
AU  - Sikirić, Biljana
AU  - Jović, Mihajlo
AU  - Šljivić-Ivanović, Marija
AU  - Čakmak, Dragan
PY  - 2019
UR  - https://www.sciencedirect.com/science/article/pii/S0016706119306172?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3391
AB  - Liming is a common practice in the treatment of acidic and metal contaminated soils, aiming at pH regulation, enhancing of the nutrient availability and attenuation of trace metals mobility. Replacement of natural limestone with alternative soil alkalizers found among waste materials represents a step towards sustainable resource management and reduced waste storage. In this study, waste seashells (SW) and red mud (RM) were applied in different doses to the soil sampled in the vicinity of mining and smelting complex. The soil was characterized by acidic reaction (pH 4.93), increased Cu concentration (219.2 mg/kg) and a very low level of P-supply (3.61 mg P2O5/100 g). The study aimed to quantify and compare additive-induced effects onto soil physicochemical properties, the status of macronutrients and distribution of trace metals. Targeted effect on soil pH was achieved with SW dose of 0.3% and RM dose of 2%. RM was found to be a source of available P and gave rise to the available P concentrations in the soil. Medium level of P-supply (15.60 mg P2O5/100 g) was achieved with RM dose of 5%, however, the increase in soil salinity and total trace elements concentrations have become significant adverse effects at such dose. The decrease in the ion-exchangeable content of Cu and other trace metals was in correlation with the increase in soil pH after the treatments. Redistribution of metal cations was mainly directed to carbonate/acid soluble and Fe, Mn-oxide bonded fraction after SW addition. Even though trace metals concentration has increased in the soil after application of the RM, they were principally found in the residual fraction. The results emphasize low amounts of contained trace elements and lower doses for achieving targeted effects on pH and metal mobility as the main benefits of SW treatments. On the other hand, moderate and controlled use of RM may represent multiple benefits in terms of simultaneous pH regulation, P-supply, and reduced trace metals mobility.
T2  - Geoderma
T1  - Interactions of acidic soil near copper mining and smelting complex and waste-derived alkaline additives
VL  - 352
DO  - 10.1016/J.GEODERMA.2019.06.015
SP  - 241
EP  - 250
ER  - 

@article{
author = "Egerić, Marija and Smičiklas, Ivana and Dojčinović, Biljana and Sikirić, Biljana and Jović, Mihajlo and Šljivić-Ivanović, Marija and Čakmak, Dragan",
year = "2019",
abstract = "Liming is a common practice in the treatment of acidic and metal contaminated soils, aiming at pH regulation, enhancing of the nutrient availability and attenuation of trace metals mobility. Replacement of natural limestone with alternative soil alkalizers found among waste materials represents a step towards sustainable resource management and reduced waste storage. In this study, waste seashells (SW) and red mud (RM) were applied in different doses to the soil sampled in the vicinity of mining and smelting complex. The soil was characterized by acidic reaction (pH 4.93), increased Cu concentration (219.2 mg/kg) and a very low level of P-supply (3.61 mg P2O5/100 g). The study aimed to quantify and compare additive-induced effects onto soil physicochemical properties, the status of macronutrients and distribution of trace metals. Targeted effect on soil pH was achieved with SW dose of 0.3% and RM dose of 2%. RM was found to be a source of available P and gave rise to the available P concentrations in the soil. Medium level of P-supply (15.60 mg P2O5/100 g) was achieved with RM dose of 5%, however, the increase in soil salinity and total trace elements concentrations have become significant adverse effects at such dose. The decrease in the ion-exchangeable content of Cu and other trace metals was in correlation with the increase in soil pH after the treatments. Redistribution of metal cations was mainly directed to carbonate/acid soluble and Fe, Mn-oxide bonded fraction after SW addition. Even though trace metals concentration has increased in the soil after application of the RM, they were principally found in the residual fraction. The results emphasize low amounts of contained trace elements and lower doses for achieving targeted effects on pH and metal mobility as the main benefits of SW treatments. On the other hand, moderate and controlled use of RM may represent multiple benefits in terms of simultaneous pH regulation, P-supply, and reduced trace metals mobility.",
journal = "Geoderma",
title = "Interactions of acidic soil near copper mining and smelting complex and waste-derived alkaline additives",
volume = "352",
doi = "10.1016/J.GEODERMA.2019.06.015",
pages = "241-250"
}

Egerić, M., Smičiklas, I., Dojčinović, B., Sikirić, B., Jović, M., Šljivić-Ivanović, M.,& Čakmak, D.. (2019). Interactions of acidic soil near copper mining and smelting complex and waste-derived alkaline additives. in Geoderma, 352, 241-250.
https://doi.org/10.1016/J.GEODERMA.2019.06.015

Egerić M, Smičiklas I, Dojčinović B, Sikirić B, Jović M, Šljivić-Ivanović M, Čakmak D. Interactions of acidic soil near copper mining and smelting complex and waste-derived alkaline additives. in Geoderma. 2019;352:241-250.
doi:10.1016/J.GEODERMA.2019.06.015 .

Egerić, Marija, Smičiklas, Ivana, Dojčinović, Biljana, Sikirić, Biljana, Jović, Mihajlo, Šljivić-Ivanović, Marija, Čakmak, Dragan, "Interactions of acidic soil near copper mining and smelting complex and waste-derived alkaline additives" in Geoderma, 352 (2019):241-250,
https://doi.org/10.1016/J.GEODERMA.2019.06.015 . .

TY  - JOUR
AU  - Čairović, Aleksandra
AU  - Stanimirović, Dragan
AU  - Krajnović, Tamara
AU  - Dojčinović, Biljana
AU  - Maksimović, Vesna
AU  - Cvijović-Alagić, Ivana
PY  - 2019
UR  - http://www.doiserbia.nb.rs/Article.aspx?ID=0354-46641900017C
UR  - http://www.serbiosoc.org.rs/arch/index.php/abs/article/view/4072
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3394
AB  - The biological quality and chemical composition of alloys used in dental practice change during heat treatment. Often the residues of the previous cast are not disposed of but are reused and recycled until consumed. Thus, manufactured dental restorations have modified biological quality and chemical composition, and compromised biocompatibility. The aim of this study was to investigate the influence of repeated casting on the cytotoxicity of the silver-palladium (Ag-Pd) alloy. Our results showed that repeated casting of the Ag-Pd dental alloy affected its biocompatibility by promoting toxicity against transformed fibroblasts in a contact-independent manner. A strong decrease in cell proliferation, induction of senescence and massive cell death were observed in cultures exposed only to a medium previously incubated with dental alloy samples. The obtained data indicated that toxicity mediated by the accumulation of the Ag, Pd, Cu and Zn cations released from the Ag-Pd material was enhanced by recasting. The induction of cell senescence and subsequent apoptotic and necrotic death were accompanied by amplified intracellular production of reactive oxygen and nitrogen species, suggesting their involvement in the cell destruction process. Therefore, compromised biocompatibility after recasting with the Ag-Pd alloy can be the cause of serious local cell destruction, as observed in clinical practice
T2  - Archives of Biological Sciences
T1  - Recasting as a booster of Ag-Pd alloy cytotoxicity: Induction of cell senescence prior to mass cell death
IS  - 2
VL  - 71
DO  - 10.2298/ABS190305017C
SP  - 347
EP  - 356
ER  - 

@article{
author = "Čairović, Aleksandra and Stanimirović, Dragan and Krajnović, Tamara and Dojčinović, Biljana and Maksimović, Vesna and Cvijović-Alagić, Ivana",
year = "2019",
abstract = "The biological quality and chemical composition of alloys used in dental practice change during heat treatment. Often the residues of the previous cast are not disposed of but are reused and recycled until consumed. Thus, manufactured dental restorations have modified biological quality and chemical composition, and compromised biocompatibility. The aim of this study was to investigate the influence of repeated casting on the cytotoxicity of the silver-palladium (Ag-Pd) alloy. Our results showed that repeated casting of the Ag-Pd dental alloy affected its biocompatibility by promoting toxicity against transformed fibroblasts in a contact-independent manner. A strong decrease in cell proliferation, induction of senescence and massive cell death were observed in cultures exposed only to a medium previously incubated with dental alloy samples. The obtained data indicated that toxicity mediated by the accumulation of the Ag, Pd, Cu and Zn cations released from the Ag-Pd material was enhanced by recasting. The induction of cell senescence and subsequent apoptotic and necrotic death were accompanied by amplified intracellular production of reactive oxygen and nitrogen species, suggesting their involvement in the cell destruction process. Therefore, compromised biocompatibility after recasting with the Ag-Pd alloy can be the cause of serious local cell destruction, as observed in clinical practice",
journal = "Archives of Biological Sciences",
title = "Recasting as a booster of Ag-Pd alloy cytotoxicity: Induction of cell senescence prior to mass cell death",
number = "2",
volume = "71",
doi = "10.2298/ABS190305017C",
pages = "347-356"
}

Čairović, A., Stanimirović, D., Krajnović, T., Dojčinović, B., Maksimović, V.,& Cvijović-Alagić, I.. (2019). Recasting as a booster of Ag-Pd alloy cytotoxicity: Induction of cell senescence prior to mass cell death. in Archives of Biological Sciences, 71(2), 347-356.
https://doi.org/10.2298/ABS190305017C

Čairović A, Stanimirović D, Krajnović T, Dojčinović B, Maksimović V, Cvijović-Alagić I. Recasting as a booster of Ag-Pd alloy cytotoxicity: Induction of cell senescence prior to mass cell death. in Archives of Biological Sciences. 2019;71(2):347-356.
doi:10.2298/ABS190305017C .

Čairović, Aleksandra, Stanimirović, Dragan, Krajnović, Tamara, Dojčinović, Biljana, Maksimović, Vesna, Cvijović-Alagić, Ivana, "Recasting as a booster of Ag-Pd alloy cytotoxicity: Induction of cell senescence prior to mass cell death" in Archives of Biological Sciences, 71, no. 2 (2019):347-356,
https://doi.org/10.2298/ABS190305017C . .

TY  - CONF
AU  - Avramov, Stevan
AU  - Kostić, Aleksandar
AU  - Dojčinović, Biljana
AU  - Milinčić, Danijel
AU  - Mačukanović-Jocić, Marina
PY  - 2018
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6668
AB  - The presence of certain elements in the soil controls their bioavailability to the plant. Uptake
of elements depends on their concentration, solubility of occurring form and soil properties. Also,
the propensity of the plant for the bioaccumulation process will condition the transfer of ions of
elements from the soil to the various parts of the plant. Sometimes good bioaccumulation properties
of plants can be used for their application for bioremediation of polluted areas.
The objective of the present study was to determine the concentrations of selected elements
in the rhizome and above-ground parts of Iris pumila grown in Deliblato Sands (Serbia) in relation
to its surrounding soil. Potassium and selenium contents (mg kg-1of dry matter) were determined
by ICP-OES method after digestion of samples. The concentration, transfer and accumulation of
some elements from the soil to rhizome and above-ground parts were evaluated in terms of Biological
Absorption Coefficient (BAC): cplant part/csoil. The concentration of K+ ions in soil, rhizome,
above-ground vegetative parts and flower were: 1,845.3 mg kg-1, 1,307.0 mg kg-1, 4,461.4 mg kg-1
and 2,875.1 mg kg-1, respectively. The presence of selenium as a trace element was confirmed both
in the soil (0.112 mg kg-1) and in the plant parts (rhizome - 0.156 mg kg-1; above-ground vegetative parts- 0.135 mg kg-1; flower - 0.122 mg kg-1). The obtained results confirmed that the aboveground
parts accumulated potassium (BACvegetative= 2.42; BACflowers= 1.56). Also, all plant parts have
shown the ability to bond selenium from soil in significant quantities (BACrhizomes= 1.38; BACvegetative= 1.20; BACflowers= 1.08). This suggests that this specie have potential in phytoremediation.
PB  - Beograd: Serbian Plant Physiology Society
C3  - Book of abstracts. 3rd International Conference on Plant Biology (22nd SPPS Meeting); 2018 Jun 9-12; Belgrade, Serbia
T1  - Bioaccumulation abilities of different parts of Iris pumila L.
SP  - 125
EP  - 126
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_6668
ER  - 

@conference{
author = "Avramov, Stevan and Kostić, Aleksandar and Dojčinović, Biljana and Milinčić, Danijel and Mačukanović-Jocić, Marina",
year = "2018",
abstract = "The presence of certain elements in the soil controls their bioavailability to the plant. Uptake
of elements depends on their concentration, solubility of occurring form and soil properties. Also,
the propensity of the plant for the bioaccumulation process will condition the transfer of ions of
elements from the soil to the various parts of the plant. Sometimes good bioaccumulation properties
of plants can be used for their application for bioremediation of polluted areas.
The objective of the present study was to determine the concentrations of selected elements
in the rhizome and above-ground parts of Iris pumila grown in Deliblato Sands (Serbia) in relation
to its surrounding soil. Potassium and selenium contents (mg kg-1of dry matter) were determined
by ICP-OES method after digestion of samples. The concentration, transfer and accumulation of
some elements from the soil to rhizome and above-ground parts were evaluated in terms of Biological
Absorption Coefficient (BAC): cplant part/csoil. The concentration of K+ ions in soil, rhizome,
above-ground vegetative parts and flower were: 1,845.3 mg kg-1, 1,307.0 mg kg-1, 4,461.4 mg kg-1
and 2,875.1 mg kg-1, respectively. The presence of selenium as a trace element was confirmed both
in the soil (0.112 mg kg-1) and in the plant parts (rhizome - 0.156 mg kg-1; above-ground vegetative parts- 0.135 mg kg-1; flower - 0.122 mg kg-1). The obtained results confirmed that the aboveground
parts accumulated potassium (BACvegetative= 2.42; BACflowers= 1.56). Also, all plant parts have
shown the ability to bond selenium from soil in significant quantities (BACrhizomes= 1.38; BACvegetative= 1.20; BACflowers= 1.08). This suggests that this specie have potential in phytoremediation.",
publisher = "Beograd: Serbian Plant Physiology Society",
journal = "Book of abstracts. 3rd International Conference on Plant Biology (22nd SPPS Meeting); 2018 Jun 9-12; Belgrade, Serbia",
title = "Bioaccumulation abilities of different parts of Iris pumila L.",
pages = "125-126",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_6668"
}

Avramov, S., Kostić, A., Dojčinović, B., Milinčić, D.,& Mačukanović-Jocić, M.. (2018). Bioaccumulation abilities of different parts of Iris pumila L.. in Book of abstracts. 3rd International Conference on Plant Biology (22nd SPPS Meeting); 2018 Jun 9-12; Belgrade, Serbia
Beograd: Serbian Plant Physiology Society., 125-126.
https://hdl.handle.net/21.15107/rcub_ibiss_6668

Avramov S, Kostić A, Dojčinović B, Milinčić D, Mačukanović-Jocić M. Bioaccumulation abilities of different parts of Iris pumila L.. in Book of abstracts. 3rd International Conference on Plant Biology (22nd SPPS Meeting); 2018 Jun 9-12; Belgrade, Serbia. 2018;:125-126.
https://hdl.handle.net/21.15107/rcub_ibiss_6668 .

Avramov, Stevan, Kostić, Aleksandar, Dojčinović, Biljana, Milinčić, Danijel, Mačukanović-Jocić, Marina, "Bioaccumulation abilities of different parts of Iris pumila L." in Book of abstracts. 3rd International Conference on Plant Biology (22nd SPPS Meeting); 2018 Jun 9-12; Belgrade, Serbia (2018):125-126,
https://hdl.handle.net/21.15107/rcub_ibiss_6668 .

TY  - CONF
AU  - Milinčić, Danijel
AU  - Avramov, Stevan
AU  - Mačukanović-Jocić, Marina
AU  - Dojčinović, Biljana
AU  - Stanojević, Slađana
AU  - Pešić, Mirjana
AU  - Kostić, Aleksandar
PY  - 2018
UR  - https://botanicaserbica.bio.bg.ac.rs/arhiva/pdf/2018_42_2_1_full.pdf
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6678
AB  - The mineral composition of the plant mainly depends on two factors – the growing soil composition and/or the influence of the environment (especially anthropogenic factor). Availability of metal’s ions in soil for plant root is determined by element form, pH-value, etc. Some plants possessed ability to concentrate (bio accumulate) some macro- or microelements. The aim of this work was to examine ability of diff erent parts of Iris humillis plant (rhizome, above-ground vegetative part and flower) to bound metal ions from surrounding growing soil or environment. Th is process was expressed as Biological
Absorption Coefficient (BAC) which was calculated as cplant part/csoil ratio where cplant part and csoil are concentration of selected element in different parts of plant i.e. in soil. Content of selected elements (potassium, phosphorus and nickel) in soil and plant was determined by ICP-OES method (including
pre-digestion of samples) and expressed as mg/kg of dry matter. Determined concentrations of potassium, phosphorus and nickel in soil were 877.1 mg/kg, 352.2 mg/kg and 2.97 mg/kg respectively. Content of selected elements in different parts of I. humillis was as follow: rhizome (K- 1686.0 mg/kg,
P- 474.2 mg/kg and Ni- 8.5 mg/kg), above-ground vegetative parts (K- 3033.1 mg/kg, P- 423.1 mg/kg and Ni- 0.29 mg/kg) and flower (K- 1461.4 mg/kg, P- 273.0 mg/kg and Ni- 0.12 mg/kg). According to results for BAC potassium was bioaccumulate in all plant parts since value of this factor was higher than 1 (BACrhizome= 1.92, BACabove-ground vegetative parts =3.46, BACflower= 1.67). Also, rhizome and above-ground vegetative part of I. humillis showed ability for bioaccumulation of phosphorus (BACrhizome= 1.35, BACabove-ground vegetative parts =1.20, BACflower= 0.78) while rhizome possessed high ability to concentrate nickel (BACrhizome= 2.86). The obtained results indicated
that this Iris species possessed good ability for Ni-bonding through rhizome. It can be important for potential bioremediation use, since increased nickel concentration in the environment
can be caused by some anthropogenic sources.
PB  - Beograd: Institute of Botany and Botanical Garden "Jevremovac", Faculty of Biology - University of Belgrade
C3  - Book of abstracts: 7th Balkan Botanical Congress; 2018 Sep 10-14; Novi Sad, Serbia. (Botanica Serbica; Vol. 42; Suppl. 1)
T1  - Bioacumulation capacity of Iris humilis
SP  - 35
EP  - 35
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_6678
ER  - 

@conference{
author = "Milinčić, Danijel and Avramov, Stevan and Mačukanović-Jocić, Marina and Dojčinović, Biljana and Stanojević, Slađana and Pešić, Mirjana and Kostić, Aleksandar",
year = "2018",
abstract = "The mineral composition of the plant mainly depends on two factors – the growing soil composition and/or the influence of the environment (especially anthropogenic factor). Availability of metal’s ions in soil for plant root is determined by element form, pH-value, etc. Some plants possessed ability to concentrate (bio accumulate) some macro- or microelements. The aim of this work was to examine ability of diff erent parts of Iris humillis plant (rhizome, above-ground vegetative part and flower) to bound metal ions from surrounding growing soil or environment. Th is process was expressed as Biological
Absorption Coefficient (BAC) which was calculated as cplant part/csoil ratio where cplant part and csoil are concentration of selected element in different parts of plant i.e. in soil. Content of selected elements (potassium, phosphorus and nickel) in soil and plant was determined by ICP-OES method (including
pre-digestion of samples) and expressed as mg/kg of dry matter. Determined concentrations of potassium, phosphorus and nickel in soil were 877.1 mg/kg, 352.2 mg/kg and 2.97 mg/kg respectively. Content of selected elements in different parts of I. humillis was as follow: rhizome (K- 1686.0 mg/kg,
P- 474.2 mg/kg and Ni- 8.5 mg/kg), above-ground vegetative parts (K- 3033.1 mg/kg, P- 423.1 mg/kg and Ni- 0.29 mg/kg) and flower (K- 1461.4 mg/kg, P- 273.0 mg/kg and Ni- 0.12 mg/kg). According to results for BAC potassium was bioaccumulate in all plant parts since value of this factor was higher than 1 (BACrhizome= 1.92, BACabove-ground vegetative parts =3.46, BACflower= 1.67). Also, rhizome and above-ground vegetative part of I. humillis showed ability for bioaccumulation of phosphorus (BACrhizome= 1.35, BACabove-ground vegetative parts =1.20, BACflower= 0.78) while rhizome possessed high ability to concentrate nickel (BACrhizome= 2.86). The obtained results indicated
that this Iris species possessed good ability for Ni-bonding through rhizome. It can be important for potential bioremediation use, since increased nickel concentration in the environment
can be caused by some anthropogenic sources.",
publisher = "Beograd: Institute of Botany and Botanical Garden "Jevremovac", Faculty of Biology - University of Belgrade",
journal = "Book of abstracts: 7th Balkan Botanical Congress; 2018 Sep 10-14; Novi Sad, Serbia. (Botanica Serbica; Vol. 42; Suppl. 1)",
title = "Bioacumulation capacity of Iris humilis",
pages = "35-35",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_6678"
}

Milinčić, D., Avramov, S., Mačukanović-Jocić, M., Dojčinović, B., Stanojević, S., Pešić, M.,& Kostić, A.. (2018). Bioacumulation capacity of Iris humilis. in Book of abstracts: 7th Balkan Botanical Congress; 2018 Sep 10-14; Novi Sad, Serbia. (Botanica Serbica; Vol. 42; Suppl. 1)
Beograd: Institute of Botany and Botanical Garden "Jevremovac", Faculty of Biology - University of Belgrade., 35-35.
https://hdl.handle.net/21.15107/rcub_ibiss_6678

Milinčić D, Avramov S, Mačukanović-Jocić M, Dojčinović B, Stanojević S, Pešić M, Kostić A. Bioacumulation capacity of Iris humilis. in Book of abstracts: 7th Balkan Botanical Congress; 2018 Sep 10-14; Novi Sad, Serbia. (Botanica Serbica; Vol. 42; Suppl. 1). 2018;:35-35.
https://hdl.handle.net/21.15107/rcub_ibiss_6678 .

Milinčić, Danijel, Avramov, Stevan, Mačukanović-Jocić, Marina, Dojčinović, Biljana, Stanojević, Slađana, Pešić, Mirjana, Kostić, Aleksandar, "Bioacumulation capacity of Iris humilis" in Book of abstracts: 7th Balkan Botanical Congress; 2018 Sep 10-14; Novi Sad, Serbia. (Botanica Serbica; Vol. 42; Suppl. 1) (2018):35-35,
https://hdl.handle.net/21.15107/rcub_ibiss_6678 .

TY  - JOUR
AU  - Jovanović, Jovana
AU  - Kolarević, Stoimir
AU  - Milošković, Aleksandra
AU  - Radojković, Nataša
AU  - Simić, Vladica
AU  - Dojčinović, Biljana
AU  - Kračun-Kolarević, Margareta
AU  - Paunović, Momir
AU  - Kostić, Jovana
AU  - Sunjog, Karolina
AU  - Gačić, Zoran
AU  - Vuković-Gačić, Branka
AU  - Timilijić, Jovana
AU  - Djordjević, Jelena
AU  - Žegura, Bojana
PY  - 2018
UR  - http://linkinghub.elsevier.com/retrieve/pii/S004896971732805X
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2887
AB  - The Velika Morava River is the greatest national Serbian river and the significant tributary of the Danube River. The major problems in the Velika Morava River Basin (VMRB) represent untreated industrial and municipal wastewaters. In this study, the level of genotoxic potential at the sites along the VMRB was evaluated by parallel in vitro and in situ approach. Within in vitro testing, genotoxicity of native water samples collected from the sites in VMRB was evaluated by SOS/umuC test on Salmonella typhimurium TA1535/pSK1002 and by the comet assay on HepG2 cells. DNA damage in situ was assessed in bleak (Alburnus alburnus) erythrocytes by the comet (alkaline and Fpg-modified comet) and micronucleus assays. Additionally, the concentration of heavy metals in fish tissue was measured and this data, compiled with the data of the physico-chemical parameters measured in water, was used as a measure of the pollution pressure at the sites. Results showed that applied in vitro tests with native water samples are less sensitive in comparison with in situ tests and should be taken with precaution when making predictions on the status of the ecosystem. Within applied battery of in situ assays differential sensitivity of assays was observed where alkaline comet assay showed the highest potential in differentiation of the sites based on genotoxic potential. Integrated biomarker response showed that usage of the battery of bioassays provides better insight in a genotoxic effects in animals, and consequently, that the holistic approach is more suitable for this type of study.
T2  - Science of The Total Environment
T1  - Evaluation of genotoxic potential in the Velika Morava River Basin in vitro and in situ
VL  - 621
DO  - 10.1016/j.scitotenv.2017.10.099
SP  - 1289
EP  - 1299
ER  - 

@article{
author = "Jovanović, Jovana and Kolarević, Stoimir and Milošković, Aleksandra and Radojković, Nataša and Simić, Vladica and Dojčinović, Biljana and Kračun-Kolarević, Margareta and Paunović, Momir and Kostić, Jovana and Sunjog, Karolina and Gačić, Zoran and Vuković-Gačić, Branka and Timilijić, Jovana and Djordjević, Jelena and Žegura, Bojana",
year = "2018",
abstract = "The Velika Morava River is the greatest national Serbian river and the significant tributary of the Danube River. The major problems in the Velika Morava River Basin (VMRB) represent untreated industrial and municipal wastewaters. In this study, the level of genotoxic potential at the sites along the VMRB was evaluated by parallel in vitro and in situ approach. Within in vitro testing, genotoxicity of native water samples collected from the sites in VMRB was evaluated by SOS/umuC test on Salmonella typhimurium TA1535/pSK1002 and by the comet assay on HepG2 cells. DNA damage in situ was assessed in bleak (Alburnus alburnus) erythrocytes by the comet (alkaline and Fpg-modified comet) and micronucleus assays. Additionally, the concentration of heavy metals in fish tissue was measured and this data, compiled with the data of the physico-chemical parameters measured in water, was used as a measure of the pollution pressure at the sites. Results showed that applied in vitro tests with native water samples are less sensitive in comparison with in situ tests and should be taken with precaution when making predictions on the status of the ecosystem. Within applied battery of in situ assays differential sensitivity of assays was observed where alkaline comet assay showed the highest potential in differentiation of the sites based on genotoxic potential. Integrated biomarker response showed that usage of the battery of bioassays provides better insight in a genotoxic effects in animals, and consequently, that the holistic approach is more suitable for this type of study.",
journal = "Science of The Total Environment",
title = "Evaluation of genotoxic potential in the Velika Morava River Basin in vitro and in situ",
volume = "621",
doi = "10.1016/j.scitotenv.2017.10.099",
pages = "1289-1299"
}

Jovanović, J., Kolarević, S., Milošković, A., Radojković, N., Simić, V., Dojčinović, B., Kračun-Kolarević, M., Paunović, M., Kostić, J., Sunjog, K., Gačić, Z., Vuković-Gačić, B., Timilijić, J., Djordjević, J.,& Žegura, B.. (2018). Evaluation of genotoxic potential in the Velika Morava River Basin in vitro and in situ. in Science of The Total Environment, 621, 1289-1299.
https://doi.org/10.1016/j.scitotenv.2017.10.099

Jovanović J, Kolarević S, Milošković A, Radojković N, Simić V, Dojčinović B, Kračun-Kolarević M, Paunović M, Kostić J, Sunjog K, Gačić Z, Vuković-Gačić B, Timilijić J, Djordjević J, Žegura B. Evaluation of genotoxic potential in the Velika Morava River Basin in vitro and in situ. in Science of The Total Environment. 2018;621:1289-1299.
doi:10.1016/j.scitotenv.2017.10.099 .

Jovanović, Jovana, Kolarević, Stoimir, Milošković, Aleksandra, Radojković, Nataša, Simić, Vladica, Dojčinović, Biljana, Kračun-Kolarević, Margareta, Paunović, Momir, Kostić, Jovana, Sunjog, Karolina, Gačić, Zoran, Vuković-Gačić, Branka, Timilijić, Jovana, Djordjević, Jelena, Žegura, Bojana, "Evaluation of genotoxic potential in the Velika Morava River Basin in vitro and in situ" in Science of The Total Environment, 621 (2018):1289-1299,
https://doi.org/10.1016/j.scitotenv.2017.10.099 . .

TY  - JOUR
AU  - Bensing, Christian
AU  - Mojić, Marija
AU  - Gómez-Ruiz, Santiago
AU  - Carralero, Sandra
AU  - Dojčinović, Biljana
AU  - Maksimović-Ivanić, Danijela
AU  - Mijatović, Sanja
AU  - Kaluđerović, Goran N.
PY  - 2016
UR  - http://xlink.rsc.org/?DOI=C6DT03519A
UR  - https://www.scopus.com/record/display.uri?eid=2-s2.0-85000774313&origin=SingleRecordEmailAlert&dgcid=scalert_sc_search_email&txGid=691E27A4B52E4CB98111082A19AFDEEC.wsnAw8kcdt7IPYLO0V48gA%3A11#
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2481
AB  - SBA-15|Sn3, a mesoporous silica-based material (derivative of SBA-15) loaded with an organotin compound Ph3Sn(CH2)3OH (Sn3), possesses improved antitumor potential against the A2780 high-grade serous ovarian carcinoma cell line in comparison to Sn3. It is demonstrated that both the compound and the nanostructured material are internalized by the A2780 cells. A similar mode of action of Sn3 and SBA-15|Sn3 against the A2780 cell line was found. Explicitly, induction of apoptosis, caspase 2, 3, 8 and 9 activation, accumulation of cells in the hypodiploid phase as well as accumulation of ROS were observed. Interestingly, Sn3 loaded in the mesoporous silica-based material needed to reach a concentration 3.5 times lower than the IC50 value of the Sn3 compound, pointing out a higher effect of the SBA-15|Sn3 than Sn3 alone. Clonogenic potential, growth in 3D culture as well as mobility of cells were disturbed in the presence of SBA-15|Sn3. Such behavior could be associated with the suppression of p-38 MAPK. Less profound effect of Sn3 compared to SBA-15|Sn3 could be attributed to a different regulation of p-38 and STAT-3, which are mainly responsible for an appropriate cellular response to diverse stimuli or metastatic properties.
T2  - Dalton Transactions
T1  - Evaluation of functionalized mesoporous silica SBA-15 as a carrier system for Ph 3 Sn(CH 2) 3 OH against the A2780 ovarian carcinoma cell line
IS  - 47
VL  - 45
DO  - 10.1039/C6DT03519A
SP  - 18984
EP  - 18993
ER  - 

@article{
author = "Bensing, Christian and Mojić, Marija and Gómez-Ruiz, Santiago and Carralero, Sandra and Dojčinović, Biljana and Maksimović-Ivanić, Danijela and Mijatović, Sanja and Kaluđerović, Goran N.",
year = "2016",
abstract = "SBA-15|Sn3, a mesoporous silica-based material (derivative of SBA-15) loaded with an organotin compound Ph3Sn(CH2)3OH (Sn3), possesses improved antitumor potential against the A2780 high-grade serous ovarian carcinoma cell line in comparison to Sn3. It is demonstrated that both the compound and the nanostructured material are internalized by the A2780 cells. A similar mode of action of Sn3 and SBA-15|Sn3 against the A2780 cell line was found. Explicitly, induction of apoptosis, caspase 2, 3, 8 and 9 activation, accumulation of cells in the hypodiploid phase as well as accumulation of ROS were observed. Interestingly, Sn3 loaded in the mesoporous silica-based material needed to reach a concentration 3.5 times lower than the IC50 value of the Sn3 compound, pointing out a higher effect of the SBA-15|Sn3 than Sn3 alone. Clonogenic potential, growth in 3D culture as well as mobility of cells were disturbed in the presence of SBA-15|Sn3. Such behavior could be associated with the suppression of p-38 MAPK. Less profound effect of Sn3 compared to SBA-15|Sn3 could be attributed to a different regulation of p-38 and STAT-3, which are mainly responsible for an appropriate cellular response to diverse stimuli or metastatic properties.",
journal = "Dalton Transactions",
title = "Evaluation of functionalized mesoporous silica SBA-15 as a carrier system for Ph 3 Sn(CH 2) 3 OH against the A2780 ovarian carcinoma cell line",
number = "47",
volume = "45",
doi = "10.1039/C6DT03519A",
pages = "18984-18993"
}

Bensing, C., Mojić, M., Gómez-Ruiz, S., Carralero, S., Dojčinović, B., Maksimović-Ivanić, D., Mijatović, S.,& Kaluđerović, G. N.. (2016). Evaluation of functionalized mesoporous silica SBA-15 as a carrier system for Ph 3 Sn(CH 2) 3 OH against the A2780 ovarian carcinoma cell line. in Dalton Transactions, 45(47), 18984-18993.
https://doi.org/10.1039/C6DT03519A

Bensing C, Mojić M, Gómez-Ruiz S, Carralero S, Dojčinović B, Maksimović-Ivanić D, Mijatović S, Kaluđerović GN. Evaluation of functionalized mesoporous silica SBA-15 as a carrier system for Ph 3 Sn(CH 2) 3 OH against the A2780 ovarian carcinoma cell line. in Dalton Transactions. 2016;45(47):18984-18993.
doi:10.1039/C6DT03519A .

Bensing, Christian, Mojić, Marija, Gómez-Ruiz, Santiago, Carralero, Sandra, Dojčinović, Biljana, Maksimović-Ivanić, Danijela, Mijatović, Sanja, Kaluđerović, Goran N., "Evaluation of functionalized mesoporous silica SBA-15 as a carrier system for Ph 3 Sn(CH 2) 3 OH against the A2780 ovarian carcinoma cell line" in Dalton Transactions, 45, no. 47 (2016):18984-18993,
https://doi.org/10.1039/C6DT03519A . .