TY  - CONF
AU  - Tatalović, Nikola
AU  - Bajrica, Mina
AU  - Mijušković, Ana
AU  - Oreščanin Dušić, Zorana
AU  - Nikolić-Kokić, Aleksandra
AU  - Spasić, Mihajlo
AU  - Blagojević, Duško
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4202
AB  - Ibogaine is a naturally occurring alkaloid isolated from the bark of the roots of the West African Tabernanthe iboga plant. It’s well known for its anti-addictive effects. On the other hand, pharmacology is quite complex, affecting many different neurotransmitter systems simultaneously. Ibogaine binds to several types of receptors: 5-Hydroxytryptamine (5-HT), opioid, nicotinic and N-methyl-D-aspartate (NMDA) receptors, dopaminergic and 5-HT transporters and monoamine oxidase enzyme (MAO). Based on our previous study showing ibogaine effects on ATP liberation (127 pM) from erythrocites in vitro, we wanted to investigate direct pharmacological ibogaine effects on aorta and mesenteric artery and to compare them with effects of ATP. Its effects were tested by isolated organ bath studies using aorta and mesenteric artery rings (with and without endothelium) isolated from Wistar rats. Aortic and mesenteric artery rings were precontracted with phenylephrine (10 µM). Ibogaine (64.4 µM) produced a relaxation in the aortic as well as in mesenteric artery rings, in a similar way. Realaxation effects were followed in time (5, 10, 20, 30, and 60 minutes) and it was shown that ibogaine effects are time-dependent. In addition, ibogaine effects are also endothelium dependent since presence of endothelium facilitated relaxation. ATP (127 pM) induced relaxation in the aortic as well as in mesenteric artery rings, and this effect is completely endothelium dependent. Taken together these findings suggest that ibogaine affect smooth muscles directly. Additionally, relaxation is endothelium dependent (possibly is mediated via nitric oxide) and ATP-mediated.
PB  - Ljubljana, Slovenia: Slovenian Biochemical Society
C3  - FEBS3+ Meeting, Molecules of Life, Book of Abstracts
T1  - Ibogaine relaxes rat arteries: the role of endothelium
SP  - 194
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_4202
ER  - 

@conference{
author = "Tatalović, Nikola and Bajrica, Mina and Mijušković, Ana and Oreščanin Dušić, Zorana and Nikolić-Kokić, Aleksandra and Spasić, Mihajlo and Blagojević, Duško",
year = "2015",
abstract = "Ibogaine is a naturally occurring alkaloid isolated from the bark of the roots of the West African Tabernanthe iboga plant. It’s well known for its anti-addictive effects. On the other hand, pharmacology is quite complex, affecting many different neurotransmitter systems simultaneously. Ibogaine binds to several types of receptors: 5-Hydroxytryptamine (5-HT), opioid, nicotinic and N-methyl-D-aspartate (NMDA) receptors, dopaminergic and 5-HT transporters and monoamine oxidase enzyme (MAO). Based on our previous study showing ibogaine effects on ATP liberation (127 pM) from erythrocites in vitro, we wanted to investigate direct pharmacological ibogaine effects on aorta and mesenteric artery and to compare them with effects of ATP. Its effects were tested by isolated organ bath studies using aorta and mesenteric artery rings (with and without endothelium) isolated from Wistar rats. Aortic and mesenteric artery rings were precontracted with phenylephrine (10 µM). Ibogaine (64.4 µM) produced a relaxation in the aortic as well as in mesenteric artery rings, in a similar way. Realaxation effects were followed in time (5, 10, 20, 30, and 60 minutes) and it was shown that ibogaine effects are time-dependent. In addition, ibogaine effects are also endothelium dependent since presence of endothelium facilitated relaxation. ATP (127 pM) induced relaxation in the aortic as well as in mesenteric artery rings, and this effect is completely endothelium dependent. Taken together these findings suggest that ibogaine affect smooth muscles directly. Additionally, relaxation is endothelium dependent (possibly is mediated via nitric oxide) and ATP-mediated.",
publisher = "Ljubljana, Slovenia: Slovenian Biochemical Society",
journal = "FEBS3+ Meeting, Molecules of Life, Book of Abstracts",
title = "Ibogaine relaxes rat arteries: the role of endothelium",
pages = "194",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_4202"
}

Tatalović, N., Bajrica, M., Mijušković, A., Oreščanin Dušić, Z., Nikolić-Kokić, A., Spasić, M.,& Blagojević, D.. (2015). Ibogaine relaxes rat arteries: the role of endothelium. in FEBS3+ Meeting, Molecules of Life, Book of Abstracts
Ljubljana, Slovenia: Slovenian Biochemical Society., 194.
https://hdl.handle.net/21.15107/rcub_ibiss_4202

Tatalović N, Bajrica M, Mijušković A, Oreščanin Dušić Z, Nikolić-Kokić A, Spasić M, Blagojević D. Ibogaine relaxes rat arteries: the role of endothelium. in FEBS3+ Meeting, Molecules of Life, Book of Abstracts. 2015;:194.
https://hdl.handle.net/21.15107/rcub_ibiss_4202 .

Tatalović, Nikola, Bajrica, Mina, Mijušković, Ana, Oreščanin Dušić, Zorana, Nikolić-Kokić, Aleksandra, Spasić, Mihajlo, Blagojević, Duško, "Ibogaine relaxes rat arteries: the role of endothelium" in FEBS3+ Meeting, Molecules of Life, Book of Abstracts (2015):194,
https://hdl.handle.net/21.15107/rcub_ibiss_4202 .