TY  - JOUR
AU  - Arambašić Jovanović, Jelena
AU  - Mihailović, Mirjana
AU  - Uskoković, Aleksandra
AU  - Grdović, Nevena
AU  - Dinić, Svetlana
AU  - Poznanović, Goran
AU  - Mujić, Ibrahim
AU  - Vidaković, Melita
PY  - 2017
UR  - http://journal.frontiersin.org/article/10.3389/fphar.2017.00793/full
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2885
AB  - The present study aimed to investigate the beneficial effects of the treatment with extracts from the edible mushroom Lactarius deterrimus (Ld) and the chestnut Castanea sativa (Cs), separately and in combination (MIX Ld/Cs), on oxidative stress and advanced glycation end-product (AGE)-mediated hepatorenal injury in a rat model of streptozotocin (STZ)-induced diabetes by examining pathways responsible for maintenance of redox homeostasis. An experimental model of diabetes was induced in rats by the administration of 40 mg/kg STZ intraperitoneally (i.p.) for five consecutive days. The examined extracts were applied separately at a dose of 60 mg/kg i.p. and in combination (60 mg/kg each extract; i.p.) for four weeks, starting from the last day of STZ administration. The improvement of hepatorenal function in diabetic rats treated with the extracts was associated with an improved glycemic and lipid status and suppression of oxidative stress and thereby oxidative damage of lipids and DNA. Besides the fact that both extracts inhibited protein glycation and AGE formation in vitro, they also reduced non-enzymatic glycosylation in diabetic rats in vivo. The observed antiglycation activity of the examined extracts (separately and in combination) was accompanied with the inhibition of CML-mediated RAGE/NF-κB activation and reduction of enzymatic O-GlcNAcylation in liver and kidney tissues of diabetic rats. Taken together, these results reveal that the administration of chestnut and mushroom extracts, either individually or together, activates a coordinated cytoprotective response against diabetes-induced hepatorenal injury not only through recovery of the antioxidant defense system of the cell, but also through a marked antiglycation activity.
PB  - Lausanne: Frontiers Media SA
T2  - Frontiers in Pharmacology
T1  - Evaluation of the Antioxidant and Antiglycation Effects of Lactarius deterrimus and Castanea sativa Extracts on Hepatorenal Injury in Streptozotocin-Induced Diabetic Rats
VL  - 8
DO  - 10.3389/fphar.2017.00793
SP  - 793
ER  - 

@article{
author = "Arambašić Jovanović, Jelena and Mihailović, Mirjana and Uskoković, Aleksandra and Grdović, Nevena and Dinić, Svetlana and Poznanović, Goran and Mujić, Ibrahim and Vidaković, Melita",
year = "2017",
abstract = "The present study aimed to investigate the beneficial effects of the treatment with extracts from the edible mushroom Lactarius deterrimus (Ld) and the chestnut Castanea sativa (Cs), separately and in combination (MIX Ld/Cs), on oxidative stress and advanced glycation end-product (AGE)-mediated hepatorenal injury in a rat model of streptozotocin (STZ)-induced diabetes by examining pathways responsible for maintenance of redox homeostasis. An experimental model of diabetes was induced in rats by the administration of 40 mg/kg STZ intraperitoneally (i.p.) for five consecutive days. The examined extracts were applied separately at a dose of 60 mg/kg i.p. and in combination (60 mg/kg each extract; i.p.) for four weeks, starting from the last day of STZ administration. The improvement of hepatorenal function in diabetic rats treated with the extracts was associated with an improved glycemic and lipid status and suppression of oxidative stress and thereby oxidative damage of lipids and DNA. Besides the fact that both extracts inhibited protein glycation and AGE formation in vitro, they also reduced non-enzymatic glycosylation in diabetic rats in vivo. The observed antiglycation activity of the examined extracts (separately and in combination) was accompanied with the inhibition of CML-mediated RAGE/NF-κB activation and reduction of enzymatic O-GlcNAcylation in liver and kidney tissues of diabetic rats. Taken together, these results reveal that the administration of chestnut and mushroom extracts, either individually or together, activates a coordinated cytoprotective response against diabetes-induced hepatorenal injury not only through recovery of the antioxidant defense system of the cell, but also through a marked antiglycation activity.",
publisher = "Lausanne: Frontiers Media SA",
journal = "Frontiers in Pharmacology",
title = "Evaluation of the Antioxidant and Antiglycation Effects of Lactarius deterrimus and Castanea sativa Extracts on Hepatorenal Injury in Streptozotocin-Induced Diabetic Rats",
volume = "8",
doi = "10.3389/fphar.2017.00793",
pages = "793"
}

Arambašić Jovanović, J., Mihailović, M., Uskoković, A., Grdović, N., Dinić, S., Poznanović, G., Mujić, I.,& Vidaković, M.. (2017). Evaluation of the Antioxidant and Antiglycation Effects of Lactarius deterrimus and Castanea sativa Extracts on Hepatorenal Injury in Streptozotocin-Induced Diabetic Rats. in Frontiers in Pharmacology
Lausanne: Frontiers Media SA., 8, 793.
https://doi.org/10.3389/fphar.2017.00793

Arambašić Jovanović J, Mihailović M, Uskoković A, Grdović N, Dinić S, Poznanović G, Mujić I, Vidaković M. Evaluation of the Antioxidant and Antiglycation Effects of Lactarius deterrimus and Castanea sativa Extracts on Hepatorenal Injury in Streptozotocin-Induced Diabetic Rats. in Frontiers in Pharmacology. 2017;8:793.
doi:10.3389/fphar.2017.00793 .

Arambašić Jovanović, Jelena, Mihailović, Mirjana, Uskoković, Aleksandra, Grdović, Nevena, Dinić, Svetlana, Poznanović, Goran, Mujić, Ibrahim, Vidaković, Melita, "Evaluation of the Antioxidant and Antiglycation Effects of Lactarius deterrimus and Castanea sativa Extracts on Hepatorenal Injury in Streptozotocin-Induced Diabetic Rats" in Frontiers in Pharmacology, 8 (2017):793,
https://doi.org/10.3389/fphar.2017.00793 . .

TY  - JOUR
AU  - Mihailović, Mirjana
AU  - Arambašić Jovanović, Jelena
AU  - Uskoković, Aleksandra
AU  - Grdović, Nevena
AU  - Dinić, Svetlana
AU  - Vidović, Senka
AU  - Poznanović, Goran
AU  - Mujić, Ibrahim
AU  - Vidaković, Melita
PY  - 2015
UR  - http://www.hindawi.com/journals/jdr/2015/576726/
UR  - http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4499631
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3174
AB  - The aim of this study was to assess the in vivo effects of the extract of the medicinal mushroom, Lactarius deterrimus, when administered (60 mg/kg, i.p.) daily for four weeks to streptozotocin- (STZ-) induced diabetic rats. Diabetic rats treated with the L. deterrimus extract displayed several improved biochemical parameters in the circulation: reduced hyperglycemia, lower triglyceride concentration and reduced glycated hemoglobin, glycated serum protein, and advanced glycation end product (AGE) levels. This treatment also adjusted the diabetes-induced redox imbalance. Thus, higher activities of the antioxidative enzymes, superoxide dismutase, and catalase in the circulation were accompanied by increased levels of free intracellular thiols and glutathionylated proteins after treatment with the L. deterrimus extract. In addition to a systemic antioxidant effect, the administration of the extract to diabetic rats also had a positive localized effect on pancreatic islets where it decreased AGE formation, and increased the expression of chemokine CXCL12 protein that mediates the restoration of β-cell population through the activation of the serine/threonine-specific Akt protein kinase prosurvival pathway. As a result, the numbers of proliferating cell nuclear antigen- (PCNA-) and insulin-positive β-cells were increased. These results show that the ability of the L. deterrimus extract to alleviate oxidative stress and increase β-cell mass represents a therapeutic potential for diabetes management.
PB  - London: Hindawi Ltd.
T2  - Journal of Diabetes Research
T1  - Protective Effects of the Mushroom Lactarius deterrimus Extract on Systemic Oxidative Stress and Pancreatic Islets in Streptozotocin-Induced Diabetic Rats.
VL  - 2015
DO  - 10.1155/2015/576726
SP  - 576726
ER  - 

@article{
author = "Mihailović, Mirjana and Arambašić Jovanović, Jelena and Uskoković, Aleksandra and Grdović, Nevena and Dinić, Svetlana and Vidović, Senka and Poznanović, Goran and Mujić, Ibrahim and Vidaković, Melita",
year = "2015",
abstract = "The aim of this study was to assess the in vivo effects of the extract of the medicinal mushroom, Lactarius deterrimus, when administered (60 mg/kg, i.p.) daily for four weeks to streptozotocin- (STZ-) induced diabetic rats. Diabetic rats treated with the L. deterrimus extract displayed several improved biochemical parameters in the circulation: reduced hyperglycemia, lower triglyceride concentration and reduced glycated hemoglobin, glycated serum protein, and advanced glycation end product (AGE) levels. This treatment also adjusted the diabetes-induced redox imbalance. Thus, higher activities of the antioxidative enzymes, superoxide dismutase, and catalase in the circulation were accompanied by increased levels of free intracellular thiols and glutathionylated proteins after treatment with the L. deterrimus extract. In addition to a systemic antioxidant effect, the administration of the extract to diabetic rats also had a positive localized effect on pancreatic islets where it decreased AGE formation, and increased the expression of chemokine CXCL12 protein that mediates the restoration of β-cell population through the activation of the serine/threonine-specific Akt protein kinase prosurvival pathway. As a result, the numbers of proliferating cell nuclear antigen- (PCNA-) and insulin-positive β-cells were increased. These results show that the ability of the L. deterrimus extract to alleviate oxidative stress and increase β-cell mass represents a therapeutic potential for diabetes management.",
publisher = "London: Hindawi Ltd.",
journal = "Journal of Diabetes Research",
title = "Protective Effects of the Mushroom Lactarius deterrimus Extract on Systemic Oxidative Stress and Pancreatic Islets in Streptozotocin-Induced Diabetic Rats.",
volume = "2015",
doi = "10.1155/2015/576726",
pages = "576726"
}

Mihailović, M., Arambašić Jovanović, J., Uskoković, A., Grdović, N., Dinić, S., Vidović, S., Poznanović, G., Mujić, I.,& Vidaković, M.. (2015). Protective Effects of the Mushroom Lactarius deterrimus Extract on Systemic Oxidative Stress and Pancreatic Islets in Streptozotocin-Induced Diabetic Rats.. in Journal of Diabetes Research
London: Hindawi Ltd.., 2015, 576726.
https://doi.org/10.1155/2015/576726

Mihailović M, Arambašić Jovanović J, Uskoković A, Grdović N, Dinić S, Vidović S, Poznanović G, Mujić I, Vidaković M. Protective Effects of the Mushroom Lactarius deterrimus Extract on Systemic Oxidative Stress and Pancreatic Islets in Streptozotocin-Induced Diabetic Rats.. in Journal of Diabetes Research. 2015;2015:576726.
doi:10.1155/2015/576726 .

Mihailović, Mirjana, Arambašić Jovanović, Jelena, Uskoković, Aleksandra, Grdović, Nevena, Dinić, Svetlana, Vidović, Senka, Poznanović, Goran, Mujić, Ibrahim, Vidaković, Melita, "Protective Effects of the Mushroom Lactarius deterrimus Extract on Systemic Oxidative Stress and Pancreatic Islets in Streptozotocin-Induced Diabetic Rats." in Journal of Diabetes Research, 2015 (2015):576726,
https://doi.org/10.1155/2015/576726 . .

TY  - JOUR
AU  - Mihailović, Mirjana
AU  - Arambašić Jovanović, Jelena
AU  - Uskoković, Aleksandra
AU  - Dinić, Svetlana
AU  - Grdović, Nevena
AU  - Marković, Jelena
AU  - Mujić, Ibrahim
AU  - Šijački, Ana D.
AU  - Poznanović, Goran
AU  - Vidaković, Melita
PY  - 2013
UR  - http://search.crossref.org/?q=10.1016%2Fj.jff.2012.10.016+
UR  - http://linkinghub.elsevier.com/retrieve/pii/S1756464612001624
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3183
AB  - The mechanisms underlying the beneficial effect observed in diabetic rats after treatment with a commercially available β-glucan-enriched extract (BGEE) were examined. Multiple low-dose streptozotocin (STZ) diabetes was used (40 mg STZ/kg) as a model for type 1 diabetes. BGEE was administered daily (80 mg/kg) for 4 weeks, starting from the last day of the STZ treatment. In vitro and in vivo experiments suggest that significant free radical scavenging and antioxidant activities of BGEE were responsible for a systemic adjustment of the redox disturbance and reduction of DNA damage in the liver and kidney of diabetic rats. BGEE-treated diabetic rats also displayed increased Akt kinase activity and decreased pro-caspase-3 degradation, implying that BGEE mediates its beneficial effects through activation of the cellular pro-survival pathway. We conclude that β-glucan administration under diabetic conditions promotes a systemic improvement that can be expected to increase the organism’s resistance to the onset of diabetic complications.
PB  - Elsevier
T2  - Journal of Functional Foods
T1  - β-Glucan administration to diabetic rats reestablishes redox balance and stimulates cellular pro-survival mechanisms
IS  - 1
VL  - 5
DO  - 10.1016/j.jff.2012.10.016
SP  - 267
EP  - 278
ER  - 

@article{
author = "Mihailović, Mirjana and Arambašić Jovanović, Jelena and Uskoković, Aleksandra and Dinić, Svetlana and Grdović, Nevena and Marković, Jelena and Mujić, Ibrahim and Šijački, Ana D. and Poznanović, Goran and Vidaković, Melita",
year = "2013",
abstract = "The mechanisms underlying the beneficial effect observed in diabetic rats after treatment with a commercially available β-glucan-enriched extract (BGEE) were examined. Multiple low-dose streptozotocin (STZ) diabetes was used (40 mg STZ/kg) as a model for type 1 diabetes. BGEE was administered daily (80 mg/kg) for 4 weeks, starting from the last day of the STZ treatment. In vitro and in vivo experiments suggest that significant free radical scavenging and antioxidant activities of BGEE were responsible for a systemic adjustment of the redox disturbance and reduction of DNA damage in the liver and kidney of diabetic rats. BGEE-treated diabetic rats also displayed increased Akt kinase activity and decreased pro-caspase-3 degradation, implying that BGEE mediates its beneficial effects through activation of the cellular pro-survival pathway. We conclude that β-glucan administration under diabetic conditions promotes a systemic improvement that can be expected to increase the organism’s resistance to the onset of diabetic complications.",
publisher = "Elsevier",
journal = "Journal of Functional Foods",
title = "β-Glucan administration to diabetic rats reestablishes redox balance and stimulates cellular pro-survival mechanisms",
number = "1",
volume = "5",
doi = "10.1016/j.jff.2012.10.016",
pages = "267-278"
}

Mihailović, M., Arambašić Jovanović, J., Uskoković, A., Dinić, S., Grdović, N., Marković, J., Mujić, I., Šijački, A. D., Poznanović, G.,& Vidaković, M.. (2013). β-Glucan administration to diabetic rats reestablishes redox balance and stimulates cellular pro-survival mechanisms. in Journal of Functional Foods
Elsevier., 5(1), 267-278.
https://doi.org/10.1016/j.jff.2012.10.016

Mihailović M, Arambašić Jovanović J, Uskoković A, Dinić S, Grdović N, Marković J, Mujić I, Šijački AD, Poznanović G, Vidaković M. β-Glucan administration to diabetic rats reestablishes redox balance and stimulates cellular pro-survival mechanisms. in Journal of Functional Foods. 2013;5(1):267-278.
doi:10.1016/j.jff.2012.10.016 .

Mihailović, Mirjana, Arambašić Jovanović, Jelena, Uskoković, Aleksandra, Dinić, Svetlana, Grdović, Nevena, Marković, Jelena, Mujić, Ibrahim, Šijački, Ana D., Poznanović, Goran, Vidaković, Melita, "β-Glucan administration to diabetic rats reestablishes redox balance and stimulates cellular pro-survival mechanisms" in Journal of Functional Foods, 5, no. 1 (2013):267-278,
https://doi.org/10.1016/j.jff.2012.10.016 . .

TY  - JOUR
AU  - Grdović, Nevena
AU  - Dinić, Svetlana
AU  - Arambašić Jovanović, Jelena
AU  - Mihailović, Mirjana
AU  - Uskoković, Aleksandra
AU  - Marković, Jelena
AU  - Poznanović, Goran
AU  - Vidović, Senka
AU  - Zeković, Zoran
AU  - Mujić, Aida
AU  - Mujić, Ibrahim
AU  - Vidaković, Melita
PY  - 2012
UR  - http://www.journals.cambridge.org/abstract_S0007114511006702
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3198
AB  - Pancreatic β-cell death or dysfunction mediated by oxidative stress underlies the development and progression of diabetes mellitus. In the present study, we tested extracts from the edible mushroom Lactarius deterrimus and the chestnut Castanea sativa, as well as their mixture (MIX Ld/Cs), for potential beneficial effects on streptozotocin (STZ)-induced pancreatic β-cell death. Analysis of chelating effects, reducing power and radical-scavenging assays revealed strong antioxidant effects of the C. sativa extract and MIX Ld/Cs, while the L. deterrimus extract displayed a weak to moderate effect. The antioxidative effect of the chestnut extract corresponds with the high content of phenolics and flavonoids identified by HPLC analysis. In contrast, the mushroom extract contains relatively small amounts of phenols and flavonoids. However, both extracts, and especially their combination MIX Ld/Cs, increased cell viability after the STZ treatment as a result of a significant reduction of DNA damage and improved redox status. The chestnut extract and MIX Ld/Cs significantly lowered the STZ-induced increases in superoxide dismutase and catalase activities, while the mushroom extract had no impact on the activities of these antioxidant enzymes. However, the L. deterrimus extract exhibited good NO-scavenging activity. Different mechanisms that underlie antioxidant effects of the mushroom and chestnut extracts were discussed. When combined as in the MIX Ld/Cs, the extracts exhibited diverse but synergistic actions that ultimately exerted beneficial and protective effects against STZ-induced pancreatic β-cell death.
PB  - Cambridge University Press
T2  - The British Journal of Nutrition
T1  - The protective effect of a mix of Lactarius deterrimus and Castanea sativa extracts on streptozotocin-induced oxidative stress and pancreatic β-cell death
IS  - 7
VL  - 108
DO  - 10.1017/S0007114511006702
SP  - 1163
EP  - 1176
ER  - 

@article{
author = "Grdović, Nevena and Dinić, Svetlana and Arambašić Jovanović, Jelena and Mihailović, Mirjana and Uskoković, Aleksandra and Marković, Jelena and Poznanović, Goran and Vidović, Senka and Zeković, Zoran and Mujić, Aida and Mujić, Ibrahim and Vidaković, Melita",
year = "2012",
abstract = "Pancreatic β-cell death or dysfunction mediated by oxidative stress underlies the development and progression of diabetes mellitus. In the present study, we tested extracts from the edible mushroom Lactarius deterrimus and the chestnut Castanea sativa, as well as their mixture (MIX Ld/Cs), for potential beneficial effects on streptozotocin (STZ)-induced pancreatic β-cell death. Analysis of chelating effects, reducing power and radical-scavenging assays revealed strong antioxidant effects of the C. sativa extract and MIX Ld/Cs, while the L. deterrimus extract displayed a weak to moderate effect. The antioxidative effect of the chestnut extract corresponds with the high content of phenolics and flavonoids identified by HPLC analysis. In contrast, the mushroom extract contains relatively small amounts of phenols and flavonoids. However, both extracts, and especially their combination MIX Ld/Cs, increased cell viability after the STZ treatment as a result of a significant reduction of DNA damage and improved redox status. The chestnut extract and MIX Ld/Cs significantly lowered the STZ-induced increases in superoxide dismutase and catalase activities, while the mushroom extract had no impact on the activities of these antioxidant enzymes. However, the L. deterrimus extract exhibited good NO-scavenging activity. Different mechanisms that underlie antioxidant effects of the mushroom and chestnut extracts were discussed. When combined as in the MIX Ld/Cs, the extracts exhibited diverse but synergistic actions that ultimately exerted beneficial and protective effects against STZ-induced pancreatic β-cell death.",
publisher = "Cambridge University Press",
journal = "The British Journal of Nutrition",
title = "The protective effect of a mix of Lactarius deterrimus and Castanea sativa extracts on streptozotocin-induced oxidative stress and pancreatic β-cell death",
number = "7",
volume = "108",
doi = "10.1017/S0007114511006702",
pages = "1163-1176"
}

Grdović, N., Dinić, S., Arambašić Jovanović, J., Mihailović, M., Uskoković, A., Marković, J., Poznanović, G., Vidović, S., Zeković, Z., Mujić, A., Mujić, I.,& Vidaković, M.. (2012). The protective effect of a mix of Lactarius deterrimus and Castanea sativa extracts on streptozotocin-induced oxidative stress and pancreatic β-cell death. in The British Journal of Nutrition
Cambridge University Press., 108(7), 1163-1176.
https://doi.org/10.1017/S0007114511006702

Grdović N, Dinić S, Arambašić Jovanović J, Mihailović M, Uskoković A, Marković J, Poznanović G, Vidović S, Zeković Z, Mujić A, Mujić I, Vidaković M. The protective effect of a mix of Lactarius deterrimus and Castanea sativa extracts on streptozotocin-induced oxidative stress and pancreatic β-cell death. in The British Journal of Nutrition. 2012;108(7):1163-1176.
doi:10.1017/S0007114511006702 .

Grdović, Nevena, Dinić, Svetlana, Arambašić Jovanović, Jelena, Mihailović, Mirjana, Uskoković, Aleksandra, Marković, Jelena, Poznanović, Goran, Vidović, Senka, Zeković, Zoran, Mujić, Aida, Mujić, Ibrahim, Vidaković, Melita, "The protective effect of a mix of Lactarius deterrimus and Castanea sativa extracts on streptozotocin-induced oxidative stress and pancreatic β-cell death" in The British Journal of Nutrition, 108, no. 7 (2012):1163-1176,
https://doi.org/10.1017/S0007114511006702 . .

TY  - CONF
AU  - Grdović, Nevena
AU  - Dinić, Svetlana
AU  - Mihailović, Mirjana
AU  - Uskoković, Aleksandra
AU  - Arambašić Jovanović, Jelena
AU  - Marković, Jelena
AU  - Poznanović, Goran
AU  - Vidović, Senka
AU  - Mujić, Ibrahim
AU  - Vidaković, Melita
PY  - 2011
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6137
PB  - Zagreb
C3  - 6th International Medicinal Mushroom Conference; 2011 Sep 25-29; Zagreb, Croatia
T1  - Antioxidant activities of two edible mushroom extracts: health benefits and risks
SP  - 95
EP  - 96
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_6137
ER  - 

@conference{
author = "Grdović, Nevena and Dinić, Svetlana and Mihailović, Mirjana and Uskoković, Aleksandra and Arambašić Jovanović, Jelena and Marković, Jelena and Poznanović, Goran and Vidović, Senka and Mujić, Ibrahim and Vidaković, Melita",
year = "2011",
publisher = "Zagreb",
journal = "6th International Medicinal Mushroom Conference; 2011 Sep 25-29; Zagreb, Croatia",
title = "Antioxidant activities of two edible mushroom extracts: health benefits and risks",
pages = "95-96",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_6137"
}

Grdović, N., Dinić, S., Mihailović, M., Uskoković, A., Arambašić Jovanović, J., Marković, J., Poznanović, G., Vidović, S., Mujić, I.,& Vidaković, M.. (2011). Antioxidant activities of two edible mushroom extracts: health benefits and risks. in 6th International Medicinal Mushroom Conference; 2011 Sep 25-29; Zagreb, Croatia
Zagreb., 95-96.
https://hdl.handle.net/21.15107/rcub_ibiss_6137

Grdović N, Dinić S, Mihailović M, Uskoković A, Arambašić Jovanović J, Marković J, Poznanović G, Vidović S, Mujić I, Vidaković M. Antioxidant activities of two edible mushroom extracts: health benefits and risks. in 6th International Medicinal Mushroom Conference; 2011 Sep 25-29; Zagreb, Croatia. 2011;:95-96.
https://hdl.handle.net/21.15107/rcub_ibiss_6137 .

Grdović, Nevena, Dinić, Svetlana, Mihailović, Mirjana, Uskoković, Aleksandra, Arambašić Jovanović, Jelena, Marković, Jelena, Poznanović, Goran, Vidović, Senka, Mujić, Ibrahim, Vidaković, Melita, "Antioxidant activities of two edible mushroom extracts: health benefits and risks" in 6th International Medicinal Mushroom Conference; 2011 Sep 25-29; Zagreb, Croatia (2011):95-96,
https://hdl.handle.net/21.15107/rcub_ibiss_6137 .

TY  - JOUR
AU  - Mujić, Aida
AU  - Grdović, Nevena
AU  - Mujić, Ibrahim
AU  - Mihailović, Mirjana
AU  - Živković, Jelena
AU  - Poznanović, Goran
AU  - Vidaković, Melita
PY  - 2011
UR  - http://www.scopus.com/inward/record.url?eid=2-s2.0-78149407400&partnerID=tZOtx3y1
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3203
AB  - Oxidative stress plays a central role in the onset of diabetes which is characterised by progressive pancreatic β-cell failure. We studied the ability of phenolic extracts prepared from chestnut leaf, catkin and spiny burs to prevent oxidative stress-induced β-cell (Rin-5F) death. The Rin-5F cell death was induced by treatment with the diabetogenic agent streptozotocin (STZ) and the protective effects of the chestnut extracts were assessed after cells treatment with a STZ/extracts mixture. The chestnut extracts increased cell viability by protecting DNA from oxidative damage and by enhancing the natural antioxidant system. Moreover, the chestnut extracts had a significant impact on the cell's redox-status which was observed as an increase in the levels of reduced glutathione. Chestnut extracts were capable of inhibiting lipid peroxidation, which was manifested as a lowering of malondialdehyde levels. We concluded that chestnut extracts increased cell viability after STZ treatment as a result of their antioxidative properties. © 2010 Elsevier Ltd.
PB  - Elsevier
T2  - Food Chemistry
T1  - Antioxidative effects of phenolic extracts from chestnut leaves, catkins and spiny burs in streptozotocin-treated rat pancreatic β-cells
IS  - 3
VL  - 125
DO  - 10.1016/j.foodchem.2010.08.068
SP  - 841
EP  - 849
ER  - 

@article{
author = "Mujić, Aida and Grdović, Nevena and Mujić, Ibrahim and Mihailović, Mirjana and Živković, Jelena and Poznanović, Goran and Vidaković, Melita",
year = "2011",
abstract = "Oxidative stress plays a central role in the onset of diabetes which is characterised by progressive pancreatic β-cell failure. We studied the ability of phenolic extracts prepared from chestnut leaf, catkin and spiny burs to prevent oxidative stress-induced β-cell (Rin-5F) death. The Rin-5F cell death was induced by treatment with the diabetogenic agent streptozotocin (STZ) and the protective effects of the chestnut extracts were assessed after cells treatment with a STZ/extracts mixture. The chestnut extracts increased cell viability by protecting DNA from oxidative damage and by enhancing the natural antioxidant system. Moreover, the chestnut extracts had a significant impact on the cell's redox-status which was observed as an increase in the levels of reduced glutathione. Chestnut extracts were capable of inhibiting lipid peroxidation, which was manifested as a lowering of malondialdehyde levels. We concluded that chestnut extracts increased cell viability after STZ treatment as a result of their antioxidative properties. © 2010 Elsevier Ltd.",
publisher = "Elsevier",
journal = "Food Chemistry",
title = "Antioxidative effects of phenolic extracts from chestnut leaves, catkins and spiny burs in streptozotocin-treated rat pancreatic β-cells",
number = "3",
volume = "125",
doi = "10.1016/j.foodchem.2010.08.068",
pages = "841-849"
}

Mujić, A., Grdović, N., Mujić, I., Mihailović, M., Živković, J., Poznanović, G.,& Vidaković, M.. (2011). Antioxidative effects of phenolic extracts from chestnut leaves, catkins and spiny burs in streptozotocin-treated rat pancreatic β-cells. in Food Chemistry
Elsevier., 125(3), 841-849.
https://doi.org/10.1016/j.foodchem.2010.08.068

Mujić A, Grdović N, Mujić I, Mihailović M, Živković J, Poznanović G, Vidaković M. Antioxidative effects of phenolic extracts from chestnut leaves, catkins and spiny burs in streptozotocin-treated rat pancreatic β-cells. in Food Chemistry. 2011;125(3):841-849.
doi:10.1016/j.foodchem.2010.08.068 .

Mujić, Aida, Grdović, Nevena, Mujić, Ibrahim, Mihailović, Mirjana, Živković, Jelena, Poznanović, Goran, Vidaković, Melita, "Antioxidative effects of phenolic extracts from chestnut leaves, catkins and spiny burs in streptozotocin-treated rat pancreatic β-cells" in Food Chemistry, 125, no. 3 (2011):841-849,
https://doi.org/10.1016/j.foodchem.2010.08.068 . .