TY  - JOUR
AU  - Davidović, Slobodan
AU  - Malyarchuk, Boris
AU  - Grzybowski, Tomasz
AU  - Aleksić, Jelena M.
AU  - Derenko, Miroslava
AU  - Litvinov, Andrey
AU  - Rogalla-Ładniak, Urszula
AU  - Stevanović, Milena
AU  - Kovačević-Grujičić, Nataša
PY  - 2020
UR  - http://link.springer.com/10.1007/s00414-020-02324-x
UR  - http://www.ncbi.nlm.nih.gov/pubmed/32504149
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3685
AB  - Mitochondrial genome (mtDNA) is a valuable resource in resolving various human forensic casework. The usage of variability of complete mtDNA genomes increases their discriminatory power to the maximum and enables ultimate resolution of distinct maternal lineages. However, their wider employment in forensic casework is nowadays limited by the lack of appropriate reference database. In order to fill in the gap in the reference data, which, considering Slavic-speaking populations, currently comprises only mitogenomes of East and West Slavs, we present mitogenome data for 226 Serbians, representatives of South Slavs from the Balkan Peninsula. We found 143 (sub)haplogroups among which West Eurasian ones were dominant. The percentage of unique haplotypes was 85%, and the random match probability was as low as 0.53%. We support previous findings on both high levels of genetic diversity in the Serbian population and patterns of genetic differentiation among this and ten studied European populations. However, our high-resolution data supported more pronounced genetic differentiation among Serbians and two Slavic populations (Russians and Poles) as well as expansion of the Serbian population after the Last Glacial Maximum and during the Migration period (fourth to ninth century A.D.), as inferred from the Bayesian skyline analysis. Phylogenetic analysis of haplotypes found in Serbians contributed towards the improvement of the worldwide mtDNA phylogeny, which is essential for the interpretation of the mtDNA casework.
PB  - Springer
T2  - International Journal of Legal Medicine
T1  - Complete mitogenome data for the Serbian population: the contribution to high-quality forensic databases.
VL  - 134
DO  - 10.1007/s00414-020-02324-x
SP  - 1581
EP  - 1590
ER  - 

@article{
author = "Davidović, Slobodan and Malyarchuk, Boris and Grzybowski, Tomasz and Aleksić, Jelena M. and Derenko, Miroslava and Litvinov, Andrey and Rogalla-Ładniak, Urszula and Stevanović, Milena and Kovačević-Grujičić, Nataša",
year = "2020",
abstract = "Mitochondrial genome (mtDNA) is a valuable resource in resolving various human forensic casework. The usage of variability of complete mtDNA genomes increases their discriminatory power to the maximum and enables ultimate resolution of distinct maternal lineages. However, their wider employment in forensic casework is nowadays limited by the lack of appropriate reference database. In order to fill in the gap in the reference data, which, considering Slavic-speaking populations, currently comprises only mitogenomes of East and West Slavs, we present mitogenome data for 226 Serbians, representatives of South Slavs from the Balkan Peninsula. We found 143 (sub)haplogroups among which West Eurasian ones were dominant. The percentage of unique haplotypes was 85%, and the random match probability was as low as 0.53%. We support previous findings on both high levels of genetic diversity in the Serbian population and patterns of genetic differentiation among this and ten studied European populations. However, our high-resolution data supported more pronounced genetic differentiation among Serbians and two Slavic populations (Russians and Poles) as well as expansion of the Serbian population after the Last Glacial Maximum and during the Migration period (fourth to ninth century A.D.), as inferred from the Bayesian skyline analysis. Phylogenetic analysis of haplotypes found in Serbians contributed towards the improvement of the worldwide mtDNA phylogeny, which is essential for the interpretation of the mtDNA casework.",
publisher = "Springer",
journal = "International Journal of Legal Medicine",
title = "Complete mitogenome data for the Serbian population: the contribution to high-quality forensic databases.",
volume = "134",
doi = "10.1007/s00414-020-02324-x",
pages = "1581-1590"
}

Davidović, S., Malyarchuk, B., Grzybowski, T., Aleksić, J. M., Derenko, M., Litvinov, A., Rogalla-Ładniak, U., Stevanović, M.,& Kovačević-Grujičić, N.. (2020). Complete mitogenome data for the Serbian population: the contribution to high-quality forensic databases.. in International Journal of Legal Medicine
Springer., 134, 1581-1590.
https://doi.org/10.1007/s00414-020-02324-x

Davidović S, Malyarchuk B, Grzybowski T, Aleksić JM, Derenko M, Litvinov A, Rogalla-Ładniak U, Stevanović M, Kovačević-Grujičić N. Complete mitogenome data for the Serbian population: the contribution to high-quality forensic databases.. in International Journal of Legal Medicine. 2020;134:1581-1590.
doi:10.1007/s00414-020-02324-x .

Davidović, Slobodan, Malyarchuk, Boris, Grzybowski, Tomasz, Aleksić, Jelena M., Derenko, Miroslava, Litvinov, Andrey, Rogalla-Ładniak, Urszula, Stevanović, Milena, Kovačević-Grujičić, Nataša, "Complete mitogenome data for the Serbian population: the contribution to high-quality forensic databases." in International Journal of Legal Medicine, 134 (2020):1581-1590,
https://doi.org/10.1007/s00414-020-02324-x . .

TY  - CONF
AU  - Kovačević-Grujičić, Nataša
AU  - Davidović, Slobodan
AU  - Malyarchuk, Boris
AU  - Grzybowski, Tomasz
AU  - Aleksić, Jelena
AU  - Derenko, Miroslava
AU  - Litvinov, Andrey
AU  - Rogalla-Ladniak, Urszula
AU  - Stevanović, Milena
PY  - 2019
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5886
AB  - Mitochondrial DNA (mtDNA) is used in forensics for over three decades and is particularly
suitable when STR profiling cannot be performed due to the degraded and/or scarce nuclear
DNA. Traditionally, mtDNA typing is based on ~600 bp of the hypervariable segments I and
II (HVS-I and HVS-II) of the control region (CR, ~1100 bp). Nowadays, it is possible to use
variability of complete mtDNAs which enables maximum resolution of distinct maternal
lineages. However, the number of complete mitogenomes in reference databases such as
EMPOP is still insufficient, and that hampers their wider usage in forensic casework. In order
to fill in the gap in the reference database, which, considering Slavic-speaking populations,
currently comprises only mitogenomes of East and West Slavs, we present population data
for 226 Serbian mitogenomes, representatives of South Slavs from the Balkan Peninsula. We
support previous findings on both high levels of genetic diversity in the Serbian population
and patterns of genetic differentiation among Serbian and ten studied European populations.
However, increased genetic differentiation was observed among Serbian and two European
populations (Russians and Poles) with our high resolution data. We demonstrate that
the inclusion of indel polymorphisms into analysis contributed towards nearly complete
resolution of mtDNA haplotypes (97.1% vs. 86.3% without indels), and that the random
match probability was as low as 0.53%. Bayesian skyline analysis of Serbian mitogenomes
revealed population expansion after the Last Glacial Maximum and during the Migration
period (IV-IX century A.D.). Phylogenetic analysis of the Serbian and relevant West Eurasian
haplotypes contributed towards the improvement of the worldwide mtDNA phylogeny to
the certain extent, which is essential for the interpretation of the mtDNA casework. Lineages
of a putative Balkan origin as well as those shared among Serbian and other European
populations were observed.
PB  - Belgrade: Serbian Genetic Society
C3  - 6th Congress of the Serbian genetic society: Book of abstracts; 2019 Oct 13-17; Vrnjačka Banja, Serbia
T1  - Whole mitochondrial genome diversity in serbian population: phylogenetic and forensic aspects
SP  - 157
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5886
ER  - 

@conference{
author = "Kovačević-Grujičić, Nataša and Davidović, Slobodan and Malyarchuk, Boris and Grzybowski, Tomasz and Aleksić, Jelena and Derenko, Miroslava and Litvinov, Andrey and Rogalla-Ladniak, Urszula and Stevanović, Milena",
year = "2019",
abstract = "Mitochondrial DNA (mtDNA) is used in forensics for over three decades and is particularly
suitable when STR profiling cannot be performed due to the degraded and/or scarce nuclear
DNA. Traditionally, mtDNA typing is based on ~600 bp of the hypervariable segments I and
II (HVS-I and HVS-II) of the control region (CR, ~1100 bp). Nowadays, it is possible to use
variability of complete mtDNAs which enables maximum resolution of distinct maternal
lineages. However, the number of complete mitogenomes in reference databases such as
EMPOP is still insufficient, and that hampers their wider usage in forensic casework. In order
to fill in the gap in the reference database, which, considering Slavic-speaking populations,
currently comprises only mitogenomes of East and West Slavs, we present population data
for 226 Serbian mitogenomes, representatives of South Slavs from the Balkan Peninsula. We
support previous findings on both high levels of genetic diversity in the Serbian population
and patterns of genetic differentiation among Serbian and ten studied European populations.
However, increased genetic differentiation was observed among Serbian and two European
populations (Russians and Poles) with our high resolution data. We demonstrate that
the inclusion of indel polymorphisms into analysis contributed towards nearly complete
resolution of mtDNA haplotypes (97.1% vs. 86.3% without indels), and that the random
match probability was as low as 0.53%. Bayesian skyline analysis of Serbian mitogenomes
revealed population expansion after the Last Glacial Maximum and during the Migration
period (IV-IX century A.D.). Phylogenetic analysis of the Serbian and relevant West Eurasian
haplotypes contributed towards the improvement of the worldwide mtDNA phylogeny to
the certain extent, which is essential for the interpretation of the mtDNA casework. Lineages
of a putative Balkan origin as well as those shared among Serbian and other European
populations were observed.",
publisher = "Belgrade: Serbian Genetic Society",
journal = "6th Congress of the Serbian genetic society: Book of abstracts; 2019 Oct 13-17; Vrnjačka Banja, Serbia",
title = "Whole mitochondrial genome diversity in serbian population: phylogenetic and forensic aspects",
pages = "157",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5886"
}

Kovačević-Grujičić, N., Davidović, S., Malyarchuk, B., Grzybowski, T., Aleksić, J., Derenko, M., Litvinov, A., Rogalla-Ladniak, U.,& Stevanović, M.. (2019). Whole mitochondrial genome diversity in serbian population: phylogenetic and forensic aspects. in 6th Congress of the Serbian genetic society: Book of abstracts; 2019 Oct 13-17; Vrnjačka Banja, Serbia
Belgrade: Serbian Genetic Society., 157.
https://hdl.handle.net/21.15107/rcub_ibiss_5886

Kovačević-Grujičić N, Davidović S, Malyarchuk B, Grzybowski T, Aleksić J, Derenko M, Litvinov A, Rogalla-Ladniak U, Stevanović M. Whole mitochondrial genome diversity in serbian population: phylogenetic and forensic aspects. in 6th Congress of the Serbian genetic society: Book of abstracts; 2019 Oct 13-17; Vrnjačka Banja, Serbia. 2019;:157.
https://hdl.handle.net/21.15107/rcub_ibiss_5886 .

Kovačević-Grujičić, Nataša, Davidović, Slobodan, Malyarchuk, Boris, Grzybowski, Tomasz, Aleksić, Jelena, Derenko, Miroslava, Litvinov, Andrey, Rogalla-Ladniak, Urszula, Stevanović, Milena, "Whole mitochondrial genome diversity in serbian population: phylogenetic and forensic aspects" in 6th Congress of the Serbian genetic society: Book of abstracts; 2019 Oct 13-17; Vrnjačka Banja, Serbia (2019):157,
https://hdl.handle.net/21.15107/rcub_ibiss_5886 .