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In vitro anti-quorum sensing activity of phytol
dc.creator | Pejin, Boris | |
dc.creator | Ćirić, Ana | |
dc.creator | Glamočlija, Jasmina | |
dc.creator | Nikolić, Miloš | |
dc.creator | Soković, Marina | |
dc.date.accessioned | 2016-05-23T10:59:53Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 1478-6427 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2002 | |
dc.description.abstract | Anti-quorum sensing activity of the diterpene phytol was evaluated in vitro for the first time. This compound (at three sub-MIC concentrations - 0.5, 0.25 and 0.125 MIC, respectively) reduced the formation of Pseudomonas aeruginosa PAO1 biofilm in the range of 74.00-84.33\% exhibiting higher activity than the both positive controls used, streptomycin and ampicillin. Phytol (0.5 MIC) also effectively reduced P. aeruginosa twitching and flagella motility. Indeed, the bacteria treated were incapable of producing a twitching zone and had almost round, smooth and regular colony edges. Finally, the tested compound (0.5 MIC) exhibited good P. aeruginosa pyocyanin inhibitory activity (51.94\%) practically to the same extent as streptomycin (52.09\%). According to the experimental data obtained, this phytol property may inspire design of medical foods targeting P. aeruginosa quorum sensing activity. | en |
dc.description.sponsorship | Ministry of Education, Science and Technological Development of the Republic of Serbia {[}172053, 173017, 173032] | |
dc.language | English | |
dc.rights | restrictedAccess | |
dc.source | Natural Product Research | |
dc.subject | biofilm | |
dc.subject | diterpene alcohol | |
dc.subject | Pseudomonas aeruginosa PAO1 | |
dc.subject | pyocyanin | |
dc.subject | twitching and flagella motility | |
dc.title | In vitro anti-quorum sensing activity of phytol | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Соковић, Марина; Пејин, Борис; Ћирић, Aна Д.; Николиц, Милос; Гламочлија, Јасмина; | |
dc.citation.issue | 4 | |
dc.citation.volume | 29 | |
dc.identifier.doi | 10.1080/14786419.2014.945088 | |
dc.identifier.scopus | 2-s2.0-84920554798 | |
dc.identifier.wos | 000346850600016 | |
dc.citation.spage | 374 | |
dc.citation.epage | 377 | |
dc.type.version | publishedVersion | en |
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