dc.creator | Reis, Filipa S. | |
dc.creator | Ćirić, Ana | |
dc.creator | Stojković, Dejan | |
dc.creator | Barros, Lillian | |
dc.creator | Ljaljevic-Grbic, Milica | |
dc.creator | Soković, Marina | |
dc.creator | Ferreira, Isabel C. F. R. | |
dc.date.accessioned | 2016-05-23T10:59:55Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 1520-5762 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2014 | |
dc.description.abstract | The genus Penicillium is well known for its importance in drug and food
production. Certain species are produced on an industrial scale for the
production of antibiotics (e.g. penicillin) or for insertion in food
(e.g. cheese). In the present work, three Penicillium species, part of
the natural mycobiota growing on various food products were selected -
P. ochrochloron, P. funiculosum and P. verrucosum var. cyclopium. The
objective of our study was to value these species from the point of view
of production of bioactive metabolites. The species were obtained after
inoculation and growth in Czapek and Malt media. Both mycelia and
culture media were analyzed to monitor the production of different
metabolites by each fungus and their release to the culture medium. The
concentrations of sugars, organic acids, phenolic acids and tocopherols
were determined. Antioxidant activity of the phenolic extracts was
evaluated, as also the antimicrobial activity of phenolic acids, organic
acids and tocopherols extracts. Rhamnose, xylose, fructose and trehalose
were found in all the mycelia and culture media; the prevailing organic
acids were oxalic and fumaric acids, and protocatechuic and
p-hydroxybenzoic acids were the most common phenolic acids; g-tocopherol
was the most abundant vitamin E isoform. Generally, the phenolic
extracts corresponding to the mycelia samples revealed higher
antioxidant activity. Concerning the antimicrobial activity there were
some fluctuations, however all the studied species revealed activity
against the tested strains. Therefore, the in-vitro bioprocesses can be
an alternative for the production of bioactive metabolites that can be
used by pharmaceutical industry. | en |
dc.description.sponsorship | Fundacao para a Ciencia e a Tecnologia (FCT, Portugal); COMPETE/QREN/EU;
CIMO {[}PEst-OE/AGR/UI0690/2011]; Serbian Ministry of Education and
Science {[}173032]; FCT; POPH-QREN; FSE {[}SFRH/BPD/4609/2008] | |
dc.language | English | |
dc.rights | restrictedAccess | |
dc.source | Drug Development and Industrial Pharmacy | |
dc.subject | Antimicrobial activity | |
dc.subject | antioxidant | |
dc.subject | fungi growth | |
dc.subject | metabolites | |
dc.subject | Penicillium | |
dc.title | Effects of different culture conditions on biological potential and
metabolites production in three Penicillium isolates | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Соковић, Марина; Реис, Филипа С.; Ферреира, Исабел Ц. Ф. Р.; Стојковиц, Дејан; Ћирић, Aна Д.; Љаљевиц-Грбиц, Милица; Баррос, Лиллиан; Еффецтс оф дифферент цултуре цондитионс он биологицал потентиал анд
метаболитес продуцтион ин тхрее Пенициллиум исолатес; | |
dc.citation.issue | 2 | |
dc.citation.volume | 41 | |
dc.identifier.doi | 10.3109/03639045.2013.858738 | |
dc.identifier.scopus | 2-s2.0-84921900837 | |
dc.identifier.wos | 000348923200012 | |
dc.citation.spage | 253 | |
dc.citation.epage | 262 | |
dc.type.version | publishedVersion | en |