dc.creator | Savić, Danijela | |
dc.creator | Stojiljkovic, Mirjana | |
dc.creator | Lavrnja, Irena | |
dc.creator | Parabucki, Ana | |
dc.creator | Bjelobaba, Ivana | |
dc.creator | Nedeljkovic, Nadezda | |
dc.creator | Herdegen, Thomas | |
dc.creator | Peković, Sanja | |
dc.date.accessioned | 2016-05-23T11:00:16Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 1532-2513 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2120 | |
dc.description.abstract | Ribavirin (RBV) is synthetic purine nucleoside analogue, licensed as
anti-viral drug that displays immunomodulatory actions on various immune
cells. Our previous ex vivo studies have demonstrated immunosuppressive
effects of RBV on reactive T-lymphocytes in experimental autoimmune
encephalomyelitis. Here, we examined the effects of RBV on inflammatory
response of microglia. RBV potency to down-regulate microglia
inflammatory response was assessed by measuring microglia cell body
size, and the production of nitric oxide (NO) and pro-and
anti-inflammatory cytokines. RBV exerted cytotoxic effects on
LPS-stimulated microglia, leaving non-stimulated microglia unaffected.
The exposure of activated microglia to RBV led to: decrease in the level
of NO as a result of decreased cell number, lower average cell surface,
the reduction of membrane ruffling, the suppression of interleukin-6
release and promoted interleukin-10 production. On the other hand, RBV
promoted LPS-induced interleukin-1 beta release. Our results imply that
RBV is a complex immunomodulator showing both anti-and pro-inflammatory
effects on activated microglia. | en |
dc.description.sponsorship | Ministry of Education, Science and Technological Development of the
Republic of Serbia {[}III41014] | |
dc.language | English | |
dc.rights | restrictedAccess | |
dc.source | Immunopharmacology and Immunotoxicology | |
dc.subject | Cytokines | |
dc.subject | cytotoxicity | |
dc.subject | inflammation | |
dc.subject | nucleoside analogue | |
dc.subject | primary
microglia | |
dc.title | Ribavirin shows immunomodulatory effects on activated microglia | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Стојиљковиц, Мирјана; Парабуцки, Aна; Недељковиц, Надезда; Бјелобаба, Ивана; Хердеген, Тхомас; Лаврња, Ирена Ц.; Савиц, Данијела; Пековић, Сања; | |
dc.citation.issue | 6 | |
dc.citation.volume | 36 | |
dc.identifier.doi | 10.3109/08923973.2014.971962 | |
dc.identifier.scopus | 2-s2.0-84964311105 | |
dc.identifier.wos | 000345209200008 | |
dc.citation.spage | 433 | |
dc.citation.epage | 441 | |
dc.type.version | publishedVersion | en |