dc.creator | Mihailović, Vladimir | |
dc.creator | Katanić, Jelena | |
dc.creator | Mišić, Danijela | |
dc.creator | Stanković, Vesna | |
dc.creator | Mihailović, Mirjana | |
dc.creator | Uskoković, Aleksandra | |
dc.creator | Arambašić Jovanović, Jelena | |
dc.creator | Solujić, Slavica | |
dc.creator | Mladenović, Milan | |
dc.creator | Stanković, Nevena | |
dc.date.accessioned | 2016-05-23T11:00:28Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 2042-650X | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2179 | |
dc.description.abstract | The objective of this work was to investigate the effects of the
methanol extracts of Gentiana cruciata L. aerial parts (GCA) and roots
(GCR) against carbon tetrachloride-induced liver injury in rats.
Pretreatment with GCA and GCR, containing sweroside, swertiamarin and
gentiopicrin in high concentrations, dose-dependently and significantly
decreased the levels of serum transaminases, alkaline phosphatase and
total bilirubin, whereas an increase in the level of total protein was
found compared with the CCl4-treated group. Moreover, oral
administration of extracts significantly enhanced antioxidant enzyme
activities (superoxide dismutase and catalase), increased the content of
glutathione and decreased the content of TBARS. Microscopic evaluations
of the liver revealed CCl4-induced lesions and related toxic
manifestations that were minimal in the liver of rats pretreated with
extracts at the dose of 400 mg per kg b.w. The results suggest that the
use of G. cruciata extracts has a merit as a potent candidate in
protecting the liver against chemical induced toxicity. | en |
dc.description.sponsorship | Ministry of Education, Science and Technology of the Republic of Serbia
{[}III 43004] | |
dc.language | English | |
dc.publisher | The Royal Society of Chemistry | |
dc.rights | restrictedAccess | |
dc.source | Food and Function | |
dc.title | Hepatoprotective effects of secoiridoid-rich extracts from Gentiana
cruciata L. against carbon tetrachloride induced liver damage in rats | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Катаниц, Јелена; Солујиц, Славица; Михаиловиц, Владимир; Ускоковић, Aлександра; Михаиловић, Мирјана В.; Станковиц, Весна; Aрамбасиц, Јелена; Мисиц, Данијела; Станковиц, Невена; Младеновиц, Милан; | |
dc.rights.holder | © 2014 by The Royal Society of Chemistry | |
dc.citation.issue | 8 | |
dc.citation.volume | 5 | |
dc.identifier.doi | 10.1039/c4fo00088a | |
dc.identifier.pmid | 24912992 | |
dc.identifier.scopus | 2-s2.0-84905020940 | |
dc.identifier.wos | 000340698400015 | |
dc.citation.spage | 1795 | |
dc.citation.epage | 1803 | |
dc.type.version | publishedVersion | en |