dc.creator | Mladenovic, Jelena M. | |
dc.creator | Paunovic, Milica G. | |
dc.creator | Matic, Milos M. | |
dc.creator | Knezevic, Veroljub S. | |
dc.creator | Ognjanovic, Branka I. | |
dc.creator | Štajn, Andraš Š. | |
dc.creator | Saičić, Zorica | |
dc.date.accessioned | 2016-05-23T11:00:41Z | |
dc.date.available | 2016-05-23T11:00:41Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 1821-4339 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2259 | |
dc.description.abstract | The effects of subchronic exposure to copper (Cu) on lipid peroxidation,
hemato-biochemical parameters, and the possible protective role of
flavonoids Quercetin and (-)-Epicatechin were studied. Male Wistar
albino rats were treated with Cu (560 mg/L, p.o. as CuCl2 center dot
2H(2)O for 5 weeks) and Quercetin and (-)-Epicatechin (40 mg/kg BW each,
i.p., every third day during the last 3 weeks) alone or in combination.
Cu increased the concentration of lipid peroxides, decreased the number
of erythrocytes, hemoglobin and hematocrit values and increased the
activities of aspartate aminotransferase, alanine aminotransferase and
lactate dehydrogenase. Coadministration of Quercetin and (-)-Epicatechin
with Cu lowered the process of lipid peroxidation and restored examined
hemato-biochemical parameters to control values. Our results indicate
that Cu induced oxidative damage in erythrocytes, which led to anemia,
while Quercetin and (-)-Epicatechin showed a protective effect on the
hemato-biochemical processes in the blood of rats. | en |
dc.description.sponsorship | Ministry of Education, Science and Technological Development of the
Republic of Serbia {[}173041] | |
dc.language | English | |
dc.rights | restrictedAccess | |
dc.source | Archives of Biological Sciences | |
dc.subject | Copper | |
dc.subject | erythrocyte | |
dc.subject | flavonoids | |
dc.subject | hematological parameters | |
dc.subject | biochemical
parameters | |
dc.subject | lipid peroxidation | |
dc.title | COPPER-INDUCED CHANGES OF LIPID PEROXIDATION AND HEMATO-BIOCHEMICAL
PARAMETERS IN RAT BLOOD: PROTECTIVE ROLE OF FLAVONOIDS | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Матиц, Милос М.; Младеновиц, Јелена М.; Саичић, Зорица; Пауновиц, Милица Г.; Штајн, Aндраш Ш.; Огњановиц, Бранка И.; Кнезевиц, Верољуб С.; | |
dc.citation.issue | 3 | |
dc.citation.volume | 66 | |
dc.identifier.doi | 10.2298/ABS1403271M | |
dc.identifier.scopus | 2-s2.0-84908159481 | |
dc.identifier.wos | 000346476900038 | |
dc.citation.spage | 1271 | |
dc.citation.epage | 1279 | |
dc.type.version | publishedVersion | en |