Effects of soy phytoestrogens on pituitary-ovarian function in middle-aged female rats
2015
Аутори:
Jarić, IvanaŽivanović, Jasmina
Ajdžanović, Vladimir
Nikolić-Kokić, Aleksandra
Stankovic, Sanja D.
Trifunović, Svetlana
Milošević, Verica
Nestorović, Nataša
Тип документа:
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт:
The aim of this study was to assess the effects of genistein (G) and
daidzein (D) on the histological, hormonal, and functional parameters of
the pituitary-ovarian axis in middle-aged female rats, and to compare
these effects with the effects of estradiol (E), commonly used in the
prevention and treatment of menopausal symptoms. Middle-aged (12 month
old) Wistar female rats subcutaneously received 35 mg/kg of G, or 35
mg/kg of D, or 0.625 mg/kg of E every day for 4 weeks. Each of the
treated groups had a corresponding control group. An intact control
group was also established. G and D did not change the intracellular
protein content within gonadotropic and lactotropic cells, but
vacuolization was observed in all the cell types. In contrast, E caused
an inhibition of gonadotropic and stimulation of lactotropic cells.
Also, ovaries of middle-aged female rats exposed to G or D have more
healthy primordial and primary follicles and less atretic follicles. E
treatment in the ovaries had a mostly negative effect, which is
reflected by the increased number of atretic follicles in all tested
classes. G and D provoked decrease in CuZnSOD and CAT activity, while E
treatment increased MnSOD and decreased CuZnSOD and GSHPx activity. All
the treatments increased serum estradiol and decreased testosterone
levels, while D and E increased the serum progesterone level. In
conclusion, soy phytoestrogens exhibited beneficial effects on
pituitary-ovarian function in middle-aged female rats, as compared to
estradiol.
Кључне речи:
Genistein; Daidzein; Estradiol; Pituitary-ovarian functionИзвор:
Endocrine, 2015, 50, 3, 764-776
DOI: 10.1007/s12020-015-0691-x
ISSN: 1559-0100