Jatrophane diterpenoids with multidrug-resistance modulating activity from the latex of Euphorbia nicaeensis.
2018
Authors:
Krstić, GordanaJadranin, Milka
Todorović, Nina M.
Pešić, Milica
Stanković, Tijana
Aljančić, Ivana S.
Tešević, Vele V.
Document Type:
Article (Published version)
,
© 2018 Elsevier Ltd
Metadata
Show full item recordAbstract:
Seven previously undescribed jatrophane diterpenoids, nicaeenin A-G, with eight known jatrophane diterpenoids, namely euphodendrophanes A-C, F, N, O, Q, S, were isolated from latex of Euphorbia nicaeensis collected in Serbia. The chemical structures of the compounds were determined by spectroscopic analysis including 1D and 2D NMR and HRESIMS experiments. All but one of the previously undescribed jatrophanes, showed significant potential to inhibit P-glycoprotein (P-gp) activity in two MDR cancer cells (NCI-H460/R and DLD1-TxR). The most powerful were nicaeenin F and nicaeenin G. Moreover nicaeenin G significantly stronger sensitized NCI-H460/R cells to DOX than Dex-VER.
Keywords:
Diterpenoids; Euphorbia nicaeensis; Euphorbiaceae; Isolation; Jatrophanes; Multi-drug resistance; P-glycoprotein; Structutre determinationSource:
Phytochemistry, 2018, 148, 104-112Funding / projects:
- Natural products of wild, cultivated and edible plants: structure and bioactivity determination (RS-MESTD-Basic Research (BR or ON)-172053)
- Identification of predictive molecular markers for cancer progression, response to therapy and disease outcome (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41031)
DOI: 10.1016/j.phytochem.2018.01.016
ISSN: 0031-9422
PubMed: 29421506
WoS: 000427334600013
Scopus: 2-s2.0-85041594265
URI
https://www.sciencedirect.com/science/article/pii/S0031942218300232?via%3Dihubhttps://radar.ibiss.bg.ac.rs/handle/123456789/3003