dc.creator | Lazarević, Milica | |
dc.creator | Nikolovski, Neda | |
dc.creator | Stanisavljević, Suzana | |
dc.creator | Dimitrijević, Mirjana | |
dc.creator | Stegnjaić, Goran | |
dc.creator | Krishnamoorthy, Gurumoorthy | |
dc.creator | Mostarica Stojković, Marija | |
dc.creator | Miljković, Đorđe | |
dc.creator | Jevtić, Bojan | |
dc.date.accessioned | 2021-04-15T11:22:14Z | |
dc.date.available | 2022-03-16 | |
dc.date.available | 2022-03-16 | |
dc.date.issued | 2021 | |
dc.identifier.issn | 0165-5728 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/4200 | |
dc.description.abstract | Experimental autoimmune encephalomyelitis (EAE) is classically induced with complete Freund's adjuvant (CFA). The immune response against CFA has a confounding influence on the translational capacity of EAE as a multiple sclerosis model. Here, we compare clinical, cellular and molecular properties between syngeneic spinal cord homogenate (SCH)- and SCH + CFA-immunized Dark Agouti rats. EAE signs were observed earlier and the cumulative clinical score was higher without CFA. Also, a higher number of immune cells infiltrates in the spinal cords was noticed at the peak of EAE without CFA. High spinal cord abundance of CD8+CD11bc+MHC class II+ cells was detected in SCH-immunized rats. Myelin basic protein -specific response can be elicited in the cells from the lymph nodes draining the site of SCH immunization. This CFA-free EAE is a reliable multiple sclerosis model. | |
dc.publisher | Elsevier BV | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200007/RS// | |
dc.relation | European Research Council starting grant (GAMES; 635617) | |
dc.relation | German research foundation (DFG) SFB TR-128 (Project A1) | |
dc.relation | Max Planck Society | |
dc.relation.isreferencedby | https://radar.ibiss.bg.ac.rs/handle/123456789/4193 | |
dc.rights | embargoedAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Journal of Neuroimmunology | |
dc.subject | CD4(+) T cells | |
dc.subject | CD8(+) macrophages | |
dc.subject | CFA | |
dc.subject | EAE | |
dc.title | Complete Freund's adjuvant-free experimental autoimmune encephalomyelitis in Dark Agouti rats is a valuable tool for multiple sclerosis studies. | |
dc.type | article | en |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Крисхнамоортхy, Гурумоортхy; Миљковић, Ђорђе; Јевтић, Бојан; Стегњаић, Горан; Ђедовић, Неда; Лазаревић, Милица; Станисављевић, Сузана; Мостарица Стојковић, Марија; Димитријевић, Мирјана; | |
dc.rights.holder | © 2021 Elsevier B.V. | |
dc.citation.volume | 354 | |
dc.description.note | This is the peer reviewed version of the following article: Lazarević M, Djedovic N, Stanisavljević S, Dimitrijević M, Stegnjaić G, Krishnamoorthy G, Mostarica Stojković M, Miljković Đ, Jevtić B. Complete Freund’s adjuvant-free experimental autoimmune encephalomyelitis in Dark Agouti rats is a valuable tool for multiple sclerosis studies. J Neuroimmunol. 2021;354:577547. [http://dx.doi.org/10.1016/j.jneuroim.2021.577547] | |
dc.identifier.doi | 10.1016/j.jneuroim.2021.577547 | |
dc.identifier.pmid | 33765502 | |
dc.identifier.scopus | 2-s2.0-85103341915 | |
dc.identifier.wos | 000640525500003 | |
dc.citation.apa | Lazarević, M., Djedovic, N., Stanisavljević, S., Dimitrijević, M., Stegnjaić, G., Krishnamoorthy, G., et al. (2021). Complete Freund’s adjuvant-free experimental autoimmune encephalomyelitis in Dark Agouti rats is a valuable tool for multiple sclerosis studies. Journal of Neuroimmunology, 354, 577547. | |
dc.citation.vancouver | Lazarević M, Djedovic N, Stanisavljević S, Dimitrijević M, Stegnjaić G, Krishnamoorthy G, Mostarica Stojković M, Miljković Đ, Jevtić B. Complete Freund’s adjuvant-free experimental autoimmune encephalomyelitis in Dark Agouti rats is a valuable tool for multiple sclerosis studies. J Neuroimmunol. 2021;354:577547. | |
dc.citation.spage | 577547 | |
dc.type.version | acceptedVersion | |
dc.identifier.fulltext | https://radar.ibiss.bg.ac.rs/bitstream/id/8383/bitstream_8383.pdf | |
dc.citation.rank | M22 | |