@article{
author = "Eichhorn, Thomas and Hey-Hawkins, Evamarie and Maksimović-Ivanić, Danijela and Mojić, Marija and Schmidt, Juergen and Mijatović, Sanja and Schmidt, Harry and Kaluđerović, Goran N.",
year = "2015",
abstract = "Neutral binuclear ruthenium complexes 1, 2, 3, 4, 5, 6, 7, 8 of the
general formula {[}\{RuCl2((6)-p-cym)\}(2)-(NN)] (NN=bis(nicotinate)-
and bis(isonicotinate)-polyethylene glycol esters:
(3-py)COO(CH2CH2O)(n)CO(3-py) and (4-py)COO(CH2CH2O)(n)CO(4-py), n
=1-4), as well as mononuclear
{[}RuCl2((6)-p-cym)((3-py)COO(CH2CH2OCH3)-N)], complex 9, were
synthesized and characterized using elemental analysis and electrospray
ionization high-resolution mass spectrometry, infrared, H-1 NMR and C-13
NMR spectroscopies. Stability of the binuclear complexes in the presence
of dimethylsulfoxide was studied. Furthermore, formation of a cationic
complex containing bridging pyridine-based bidentate ligand was
monitored using H-1 NMR spectroscopy. Ligand precursors, polyethylene
glycol esters of nicotinic (L12HCl-L42HCl and L9HCl) and isonicotinic
acid dihydrochlorides (L52HCl-L82HCl), binuclear ruthenium(II) complexes
1, 2, 3, 4, 5, 6, 7, 8 and mononuclear complex 9 were tested for in
vitro cytotoxicity against 518A2 (melanoma), 8505C (anaplastic thyroid
cancer), A253 (head and neck tumour), MCF-7 (breast tumour) and SW480
(colon carcinoma) cell lines. Copyright (c) 2014 John Wiley \& Sons,
Ltd.",
journal = "Applied Organometallic Chemistry",
title = "Binuclear dichlorido(eta(6)-p-cymene)ruthenium(II) complexes with
bis(nicotinate)- and bis (isonicotinate)-polyethylene glycol ester
ligands",
number = "1",
volume = "29",
doi = "10.1002/aoc.3238",
pages = "20-25"
}