Bracht, Adelar

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  • Bracht, Adelar (5)
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Author's Bibliography

Purple tea: chemical characterization and evaluation as inhibitor of pancreatic lipase and fat digestion in mice

da Silva, Tamires Barlati Vieira; Dias, Maria Inês; Pereira, Carla; Mandim, Filipa; Ivanov, Marija; Soković, Marina; Ferreira, Isabel C. F. R.; Barros, Lillian; Seixas, Flávio Augusto Vicente; Bracht, Adelar; Peralta, Rosane Marina

(2023)

TY  - JOUR
AU  - da Silva, Tamires Barlati Vieira
AU  - Dias, Maria Inês
AU  - Pereira, Carla
AU  - Mandim, Filipa
AU  - Ivanov, Marija
AU  - Soković, Marina
AU  - Ferreira, Isabel C. F. R.
AU  - Barros, Lillian
AU  - Seixas, Flávio Augusto Vicente
AU  - Bracht, Adelar
AU  - Peralta, Rosane Marina
PY  - 2023
UR  - http://xlink.rsc.org/?DOI=D2FO02442J
UR  - http://www.ncbi.nlm.nih.gov/pubmed/36723015
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5465
AB  - A variety of the classic green tea plant, Camellia sinensis, was developed and is exclusive to Kenya. Due to high content of anthocyanin polyphenols in its leaves, the beverage obtained from this variety is purple in color and is the origin of the name purple tea. This work had two main purposes. The first one was to identify and quantify the major anthocyanin polyphenols in a hot water aqueous extract of the purple tea leaves. The second one was to test the hypothesis if this extract is capable of inhibiting triglyceride absorption considering that anthocyanin polyphenolics have been frequently associated to antilipidemic effects. Parallel experiments were always done with a similar green tea extract for comparison purposes. The antioxidant, anti-inflammatory, and cytotoxic activities of both tea varieties are similar. The purple tea extract, however, was strongly inhibitory toward the pancreatic lipase (minimal IC50 = 67.4 μg mL-1), whereas the green tea preparation was a weak inhibitor. Triglyceride digestion in mice was inhibited by the purple tea extract starting at 100 mg kg-1 dose and with a well-defined dose dependence. Green tea had no effect on triglyceride digestion at doses up to 500 mg kg-1. The latter effect is probably caused by several components in the purple tea extract including non-anthocyanin and anthocyanin polyphenols, the first ones acting solely via the inhibition of the pancreatic lipase and the latter by inhibiting both the lipase and the transport of free fatty acids from the intestinal lumen into the circulating blood. The results suggest that the regular consumption of Kenyan purple tea can be useful in the control of obesity.
T2  - Food & Function
T1  - Purple tea: chemical characterization and evaluation as inhibitor of pancreatic lipase and fat digestion in mice
IS  - 3
VL  - 14
DO  - 10.1039/d2fo02442j
SP  - 1761
EP  - 1772
ER  - 
@article{
author = "da Silva, Tamires Barlati Vieira and Dias, Maria Inês and Pereira, Carla and Mandim, Filipa and Ivanov, Marija and Soković, Marina and Ferreira, Isabel C. F. R. and Barros, Lillian and Seixas, Flávio Augusto Vicente and Bracht, Adelar and Peralta, Rosane Marina",
year = "2023",
abstract = "A variety of the classic green tea plant, Camellia sinensis, was developed and is exclusive to Kenya. Due to high content of anthocyanin polyphenols in its leaves, the beverage obtained from this variety is purple in color and is the origin of the name purple tea. This work had two main purposes. The first one was to identify and quantify the major anthocyanin polyphenols in a hot water aqueous extract of the purple tea leaves. The second one was to test the hypothesis if this extract is capable of inhibiting triglyceride absorption considering that anthocyanin polyphenolics have been frequently associated to antilipidemic effects. Parallel experiments were always done with a similar green tea extract for comparison purposes. The antioxidant, anti-inflammatory, and cytotoxic activities of both tea varieties are similar. The purple tea extract, however, was strongly inhibitory toward the pancreatic lipase (minimal IC50 = 67.4 μg mL-1), whereas the green tea preparation was a weak inhibitor. Triglyceride digestion in mice was inhibited by the purple tea extract starting at 100 mg kg-1 dose and with a well-defined dose dependence. Green tea had no effect on triglyceride digestion at doses up to 500 mg kg-1. The latter effect is probably caused by several components in the purple tea extract including non-anthocyanin and anthocyanin polyphenols, the first ones acting solely via the inhibition of the pancreatic lipase and the latter by inhibiting both the lipase and the transport of free fatty acids from the intestinal lumen into the circulating blood. The results suggest that the regular consumption of Kenyan purple tea can be useful in the control of obesity.",
journal = "Food & Function",
title = "Purple tea: chemical characterization and evaluation as inhibitor of pancreatic lipase and fat digestion in mice",
number = "3",
volume = "14",
doi = "10.1039/d2fo02442j",
pages = "1761-1772"
}
da Silva, T. B. V., Dias, M. I., Pereira, C., Mandim, F., Ivanov, M., Soković, M., Ferreira, I. C. F. R., Barros, L., Seixas, F. A. V., Bracht, A.,& Peralta, R. M.. (2023). Purple tea: chemical characterization and evaluation as inhibitor of pancreatic lipase and fat digestion in mice. in Food & Function, 14(3), 1761-1772.
https://doi.org/10.1039/d2fo02442j
da Silva TBV, Dias MI, Pereira C, Mandim F, Ivanov M, Soković M, Ferreira ICFR, Barros L, Seixas FAV, Bracht A, Peralta RM. Purple tea: chemical characterization and evaluation as inhibitor of pancreatic lipase and fat digestion in mice. in Food & Function. 2023;14(3):1761-1772.
doi:10.1039/d2fo02442j .
da Silva, Tamires Barlati Vieira, Dias, Maria Inês, Pereira, Carla, Mandim, Filipa, Ivanov, Marija, Soković, Marina, Ferreira, Isabel C. F. R., Barros, Lillian, Seixas, Flávio Augusto Vicente, Bracht, Adelar, Peralta, Rosane Marina, "Purple tea: chemical characterization and evaluation as inhibitor of pancreatic lipase and fat digestion in mice" in Food & Function, 14, no. 3 (2023):1761-1772,
https://doi.org/10.1039/d2fo02442j . .
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Polyphenolic profile and pharmacological activities of whips horse (Luehea divaricata) bark extracts studied using in vitro and in vivo systems

Garcia-Manieri, Jéssica A.A; Correa, Vanesa Gesser; Corrêa, Rúbia Carvalho Gomes; Dias, Maria Inês; Calhelha, Ricardo C.; Ivanov, Marija; Soković, Marina; Barros, Lillian; Ferreira, Isabel C.F.R.; Bracht, Adelar; Peralta, Rosane M.

(Amsterdam: Elsevier, 2022)

TY  - JOUR
AU  - Garcia-Manieri, Jéssica A.A
AU  - Correa, Vanesa Gesser
AU  - Corrêa, Rúbia Carvalho Gomes
AU  - Dias, Maria Inês
AU  - Calhelha, Ricardo C.
AU  - Ivanov, Marija
AU  - Soković, Marina
AU  - Barros, Lillian
AU  - Ferreira, Isabel C.F.R.
AU  - Bracht, Adelar
AU  - Peralta, Rosane M.
PY  - 2022
UR  - https://linkinghub.elsevier.com/retrieve/pii/S1878818122002572
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5341
AB  - Leaves and barks of Luehea divaricata (Malvaceae) are used in folk medicine for the treatment of infectious diseases, tumors, rheumatism and diabetes. This work presents in vivo experiments (rats and mice) supported by in vitro and chemical analyses in order to address the above mentioned folk medicinal uses. The phenolic constituents of both aqueous and hydroalcoholic extracts are mainly catechin derivatives (135.4 and 215.9 mg/g, respectively). Both extracts displayed strong antioxidant activity. They also showed antiproliferative activities against tumor cells, nitric oxide synthesis inhibition (indicative of anti-inflammatory activity) and antimicrobial activity against a variety of infectious agents. Paracetamol-induced liver injury in rats, which has a high inflammatory component, was substantially attenuated in animals treated with the hydro-alcoholic extract (200 mg kg−1 day−1). This was deduced from aspartate aminotransferase and alanine aminotransferase measurements in plasma as well as from the hepatic activities of catalase and superoxide dismutase. Both extracts inhibited the pancreatic α-amylase with IC50 values of 11.50 ± 0.05 and 18.70 ± 3.87 μg/mL for the hydro-alcoholic and aqueous extract, respectively. Both extracts inhibited starch digestion in mice at the doses of 200 and 400 mg/kg. In general terms the results confirm several of the vox populi notions about the therapeutic potential of L. divaricata, the antidiabetic action, combined with the hepatoprotective effect, being the most relevant observations. Not less important is the economical perspective for the rural producers which may eventually increase their revenue by selling increasingly valued raw materials derived from L. divaricata based on its therapeutic properties.
PB  - Amsterdam: Elsevier
T2  - Biocatalysis and Agricultural Biotechnology
T1  - Polyphenolic profile and pharmacological activities of whips horse (Luehea divaricata) bark extracts studied using in vitro and in vivo systems
VL  - 45
DO  - 10.1016/j.bcab.2022.102530
SP  - 102530
ER  - 
@article{
author = "Garcia-Manieri, Jéssica A.A and Correa, Vanesa Gesser and Corrêa, Rúbia Carvalho Gomes and Dias, Maria Inês and Calhelha, Ricardo C. and Ivanov, Marija and Soković, Marina and Barros, Lillian and Ferreira, Isabel C.F.R. and Bracht, Adelar and Peralta, Rosane M.",
year = "2022",
abstract = "Leaves and barks of Luehea divaricata (Malvaceae) are used in folk medicine for the treatment of infectious diseases, tumors, rheumatism and diabetes. This work presents in vivo experiments (rats and mice) supported by in vitro and chemical analyses in order to address the above mentioned folk medicinal uses. The phenolic constituents of both aqueous and hydroalcoholic extracts are mainly catechin derivatives (135.4 and 215.9 mg/g, respectively). Both extracts displayed strong antioxidant activity. They also showed antiproliferative activities against tumor cells, nitric oxide synthesis inhibition (indicative of anti-inflammatory activity) and antimicrobial activity against a variety of infectious agents. Paracetamol-induced liver injury in rats, which has a high inflammatory component, was substantially attenuated in animals treated with the hydro-alcoholic extract (200 mg kg−1 day−1). This was deduced from aspartate aminotransferase and alanine aminotransferase measurements in plasma as well as from the hepatic activities of catalase and superoxide dismutase. Both extracts inhibited the pancreatic α-amylase with IC50 values of 11.50 ± 0.05 and 18.70 ± 3.87 μg/mL for the hydro-alcoholic and aqueous extract, respectively. Both extracts inhibited starch digestion in mice at the doses of 200 and 400 mg/kg. In general terms the results confirm several of the vox populi notions about the therapeutic potential of L. divaricata, the antidiabetic action, combined with the hepatoprotective effect, being the most relevant observations. Not less important is the economical perspective for the rural producers which may eventually increase their revenue by selling increasingly valued raw materials derived from L. divaricata based on its therapeutic properties.",
publisher = "Amsterdam: Elsevier",
journal = "Biocatalysis and Agricultural Biotechnology",
title = "Polyphenolic profile and pharmacological activities of whips horse (Luehea divaricata) bark extracts studied using in vitro and in vivo systems",
volume = "45",
doi = "10.1016/j.bcab.2022.102530",
pages = "102530"
}
Garcia-Manieri, J. A.A, Correa, V. G., Corrêa, R. C. G., Dias, M. I., Calhelha, R. C., Ivanov, M., Soković, M., Barros, L., Ferreira, I. C.F.R., Bracht, A.,& Peralta, R. M.. (2022). Polyphenolic profile and pharmacological activities of whips horse (Luehea divaricata) bark extracts studied using in vitro and in vivo systems. in Biocatalysis and Agricultural Biotechnology
Amsterdam: Elsevier., 45, 102530.
https://doi.org/10.1016/j.bcab.2022.102530
Garcia-Manieri JA, Correa VG, Corrêa RCG, Dias MI, Calhelha RC, Ivanov M, Soković M, Barros L, Ferreira IC, Bracht A, Peralta RM. Polyphenolic profile and pharmacological activities of whips horse (Luehea divaricata) bark extracts studied using in vitro and in vivo systems. in Biocatalysis and Agricultural Biotechnology. 2022;45:102530.
doi:10.1016/j.bcab.2022.102530 .
Garcia-Manieri, Jéssica A.A, Correa, Vanesa Gesser, Corrêa, Rúbia Carvalho Gomes, Dias, Maria Inês, Calhelha, Ricardo C., Ivanov, Marija, Soković, Marina, Barros, Lillian, Ferreira, Isabel C.F.R., Bracht, Adelar, Peralta, Rosane M., "Polyphenolic profile and pharmacological activities of whips horse (Luehea divaricata) bark extracts studied using in vitro and in vivo systems" in Biocatalysis and Agricultural Biotechnology, 45 (2022):102530,
https://doi.org/10.1016/j.bcab.2022.102530 . .
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Antioxidant and antimicrobial activities of a purified polysaccharide from yerba mate (Ilex paraguariensis)

Kungel, Pâmela T.A.N.; Correa, Vanesa G.; Corrêa, Rúbia C.G.; Peralta, Rosely Aparecida; Soković, Marina; Calhelha, Ricardo C.; Bracht, Adelar; Ferreira, Isabel C.F.R.; Peralta, Rosane M.

(2018)

TY  - JOUR
AU  - Kungel, Pâmela T.A.N.
AU  - Correa, Vanesa G.
AU  - Corrêa, Rúbia C.G.
AU  - Peralta, Rosely Aparecida
AU  - Soković, Marina
AU  - Calhelha, Ricardo C.
AU  - Bracht, Adelar
AU  - Ferreira, Isabel C.F.R.
AU  - Peralta, Rosane M.
PY  - 2018
UR  - https://www.sciencedirect.com/science/article/pii/S0141813018308134?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3044
AB  - This study investigated the antioxidant, antimicrobial and cytotoxic properties of a purified yerba mate polysaccharide. The yerba mate polysaccharide showed a prominent antioxidant activity as evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH)-radical scavenging activity (IC50=1.25±0.10mg/mL), 3-ethyl benzothiazoline-6-sulphonic acid (ABTS+)-radical scavenging activity (IC50=0.41±0.05mg/mL), and hydroxyl scavenging activity (IC50=3.36±0.31mg/mL). The antioxidant activity evaluated as the ferric ion reduction power (FRAP) and oxygen radical absorbance radical assay (ORAC), expressed as trolox equivalents, were 20.84±1.61μMTE/mg and 556.30±12.83μMTE/mg, respectively. The purified yerba mate polysaccharide presented high antimicrobial activity against several bacterial and fungal strains; however, no cytotoxicity against all four tumor human cell lines assessed.
T2  - International Journal of Biological Macromolecules
T1  - Antioxidant and antimicrobial activities of a purified polysaccharide from yerba mate (Ilex paraguariensis)
VL  - 114
DO  - 10.1016/J.IJBIOMAC.2018.04.020
SP  - 1161
EP  - 1167
ER  - 
@article{
author = "Kungel, Pâmela T.A.N. and Correa, Vanesa G. and Corrêa, Rúbia C.G. and Peralta, Rosely Aparecida and Soković, Marina and Calhelha, Ricardo C. and Bracht, Adelar and Ferreira, Isabel C.F.R. and Peralta, Rosane M.",
year = "2018",
abstract = "This study investigated the antioxidant, antimicrobial and cytotoxic properties of a purified yerba mate polysaccharide. The yerba mate polysaccharide showed a prominent antioxidant activity as evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH)-radical scavenging activity (IC50=1.25±0.10mg/mL), 3-ethyl benzothiazoline-6-sulphonic acid (ABTS+)-radical scavenging activity (IC50=0.41±0.05mg/mL), and hydroxyl scavenging activity (IC50=3.36±0.31mg/mL). The antioxidant activity evaluated as the ferric ion reduction power (FRAP) and oxygen radical absorbance radical assay (ORAC), expressed as trolox equivalents, were 20.84±1.61μMTE/mg and 556.30±12.83μMTE/mg, respectively. The purified yerba mate polysaccharide presented high antimicrobial activity against several bacterial and fungal strains; however, no cytotoxicity against all four tumor human cell lines assessed.",
journal = "International Journal of Biological Macromolecules",
title = "Antioxidant and antimicrobial activities of a purified polysaccharide from yerba mate (Ilex paraguariensis)",
volume = "114",
doi = "10.1016/J.IJBIOMAC.2018.04.020",
pages = "1161-1167"
}
Kungel, P. T.A.N., Correa, V. G., Corrêa, R. C.G., Peralta, R. A., Soković, M., Calhelha, R. C., Bracht, A., Ferreira, I. C.F.R.,& Peralta, R. M.. (2018). Antioxidant and antimicrobial activities of a purified polysaccharide from yerba mate (Ilex paraguariensis). in International Journal of Biological Macromolecules, 114, 1161-1167.
https://doi.org/10.1016/J.IJBIOMAC.2018.04.020
Kungel PT, Correa VG, Corrêa RC, Peralta RA, Soković M, Calhelha RC, Bracht A, Ferreira IC, Peralta RM. Antioxidant and antimicrobial activities of a purified polysaccharide from yerba mate (Ilex paraguariensis). in International Journal of Biological Macromolecules. 2018;114:1161-1167.
doi:10.1016/J.IJBIOMAC.2018.04.020 .
Kungel, Pâmela T.A.N., Correa, Vanesa G., Corrêa, Rúbia C.G., Peralta, Rosely Aparecida, Soković, Marina, Calhelha, Ricardo C., Bracht, Adelar, Ferreira, Isabel C.F.R., Peralta, Rosane M., "Antioxidant and antimicrobial activities of a purified polysaccharide from yerba mate (Ilex paraguariensis)" in International Journal of Biological Macromolecules, 114 (2018):1161-1167,
https://doi.org/10.1016/J.IJBIOMAC.2018.04.020 . .
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A natural food ingredient based on ergosterol: optimization of the extraction from Agaricus blazei, evaluation of bioactive properties and incorporation in yogurts.

Corrêa, Rúbia C. G.; Barros, Lillian; Fernandes, Ângela; Soković, Marina; Bracht, Adelar; Peralta, Rosane M.; Ferreira, Isabel C. F. R.

(2018)

TY  - JOUR
AU  - Corrêa, Rúbia C. G.
AU  - Barros, Lillian
AU  - Fernandes, Ângela
AU  - Soković, Marina
AU  - Bracht, Adelar
AU  - Peralta, Rosane M.
AU  - Ferreira, Isabel C. F. R.
PY  - 2018
UR  - http://xlink.rsc.org/?DOI=C7FO02007D
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3028
AB  - In recent years, mycosterols have emerged as potential functional ingredients for the development of sterol-enriched food products and dietary supplements. Agaricus blazei is a mushroom rich in bioactive compounds. For commercial purposes, their fruiting bodies must obey rigid morphological criteria. Those not conforming to these criteria are usually discarded, although this does not mean impairment of their content in bioactives. The aim of the present work was to propose the use of commercially discarded A. blazei fruiting bodies for obtaining an extract rich in ergosterol as a fortifier ingredient for yogurts. For extraction, the Soxhlet technology was used and the highest ergosterol yield (around 12%) was achieved in the 5thcycle, yielding 58.53 ± 1.72 µg of ergosterol per 100 g of mushroom (dry weight). The ergosterol rich extract presented notable antioxidant and antimicrobial properties, besides showing no hepatotoxicity. When added to the yogurts it significantly enhanced their antioxidant properties. Furthermore, it did not significantly alter the nutritional or the individual fatty acid profiles of the final dairy products. Thus, A. blazei fruiting bodies that do not conform to the commercial requirements of the market and are normally discarded could be exploited for obtaining a natural high added-value food additive, following the circular bioeconomy concept.
T2  - Food and Function
T1  - A natural food ingredient based on ergosterol: optimization of the extraction from Agaricus blazei, evaluation of bioactive properties and incorporation in yogurts.
IS  - 3
VL  - 9
DO  - 10.1039/c7fo02007d
SP  - 1465
EP  - 1474
ER  - 
@article{
author = "Corrêa, Rúbia C. G. and Barros, Lillian and Fernandes, Ângela and Soković, Marina and Bracht, Adelar and Peralta, Rosane M. and Ferreira, Isabel C. F. R.",
year = "2018",
abstract = "In recent years, mycosterols have emerged as potential functional ingredients for the development of sterol-enriched food products and dietary supplements. Agaricus blazei is a mushroom rich in bioactive compounds. For commercial purposes, their fruiting bodies must obey rigid morphological criteria. Those not conforming to these criteria are usually discarded, although this does not mean impairment of their content in bioactives. The aim of the present work was to propose the use of commercially discarded A. blazei fruiting bodies for obtaining an extract rich in ergosterol as a fortifier ingredient for yogurts. For extraction, the Soxhlet technology was used and the highest ergosterol yield (around 12%) was achieved in the 5thcycle, yielding 58.53 ± 1.72 µg of ergosterol per 100 g of mushroom (dry weight). The ergosterol rich extract presented notable antioxidant and antimicrobial properties, besides showing no hepatotoxicity. When added to the yogurts it significantly enhanced their antioxidant properties. Furthermore, it did not significantly alter the nutritional or the individual fatty acid profiles of the final dairy products. Thus, A. blazei fruiting bodies that do not conform to the commercial requirements of the market and are normally discarded could be exploited for obtaining a natural high added-value food additive, following the circular bioeconomy concept.",
journal = "Food and Function",
title = "A natural food ingredient based on ergosterol: optimization of the extraction from Agaricus blazei, evaluation of bioactive properties and incorporation in yogurts.",
number = "3",
volume = "9",
doi = "10.1039/c7fo02007d",
pages = "1465-1474"
}
Corrêa, R. C. G., Barros, L., Fernandes, Â., Soković, M., Bracht, A., Peralta, R. M.,& Ferreira, I. C. F. R.. (2018). A natural food ingredient based on ergosterol: optimization of the extraction from Agaricus blazei, evaluation of bioactive properties and incorporation in yogurts.. in Food and Function, 9(3), 1465-1474.
https://doi.org/10.1039/c7fo02007d
Corrêa RCG, Barros L, Fernandes Â, Soković M, Bracht A, Peralta RM, Ferreira ICFR. A natural food ingredient based on ergosterol: optimization of the extraction from Agaricus blazei, evaluation of bioactive properties and incorporation in yogurts.. in Food and Function. 2018;9(3):1465-1474.
doi:10.1039/c7fo02007d .
Corrêa, Rúbia C. G., Barros, Lillian, Fernandes, Ângela, Soković, Marina, Bracht, Adelar, Peralta, Rosane M., Ferreira, Isabel C. F. R., "A natural food ingredient based on ergosterol: optimization of the extraction from Agaricus blazei, evaluation of bioactive properties and incorporation in yogurts." in Food and Function, 9, no. 3 (2018):1465-1474,
https://doi.org/10.1039/c7fo02007d . .
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Bioactive formulations prepared from fruiting bodies and submerged culture mycelia of the Brazilian edible mushroom Pleurotus ostreatoroseus Singer

Gomes Correa, Rubia Carvalho; Henrique Pereira de Souza, Aloisio; Calhelha, Ricardo C.; Barros, Lillian; Glamočlija, Jasmina; Soković, Marina; Peralta, Rosane Marina; Bracht, Adelar; Ferreira, Isabel C. F. R.

(2015)

TY  - JOUR
AU  - Gomes Correa, Rubia Carvalho
AU  - Henrique Pereira de Souza, Aloisio
AU  - Calhelha, Ricardo C.
AU  - Barros, Lillian
AU  - Glamočlija, Jasmina
AU  - Soković, Marina
AU  - Peralta, Rosane Marina
AU  - Bracht, Adelar
AU  - Ferreira, Isabel C. F. R.
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2056
AB  - Pleurotus ostreatoroseus is a Brazilian edible mushroom whose chemical
   characterization and bioactivity still remain underexplored. In this
   study, the hydrophilic and lipophilic compounds as well as the
   antioxidant, anti-inflammatory and antimicrobial activities of
   formulations (ethanol extracts) prepared with its fruiting bodies and
   submerged culture mycelia were compared. The bioactive formulations
   contain at least five free sugars, four organic acids, four phenolic
   compounds and two tocopherols. The fruiting body-based formulation
   revealed higher reducing power, DPPH scavenging activity, beta-carotene
   bleaching inhibition and lipid peroxidation inhibition in brain
   homogenates than the mycelium-based preparation, as well as higher
   anti-inflammatory and antimicrobial activities. The absence of
   hepatotoxicity was confirmed in porcine liver primary cells. These
   functional responses can be related to the levels of bioactive
   components including phenolic acids, organic acids and tocopherols.
T2  - Food & Function
T1  - Bioactive formulations prepared from fruiting bodies and submerged
 culture mycelia of the Brazilian edible mushroom Pleurotus
 ostreatoroseus Singer
IS  - 7
VL  - 6
DO  - 10.1039/c5fo00465a
SP  - 2155
EP  - 2164
ER  - 
@article{
author = "Gomes Correa, Rubia Carvalho and Henrique Pereira de Souza, Aloisio and Calhelha, Ricardo C. and Barros, Lillian and Glamočlija, Jasmina and Soković, Marina and Peralta, Rosane Marina and Bracht, Adelar and Ferreira, Isabel C. F. R.",
year = "2015",
abstract = "Pleurotus ostreatoroseus is a Brazilian edible mushroom whose chemical
   characterization and bioactivity still remain underexplored. In this
   study, the hydrophilic and lipophilic compounds as well as the
   antioxidant, anti-inflammatory and antimicrobial activities of
   formulations (ethanol extracts) prepared with its fruiting bodies and
   submerged culture mycelia were compared. The bioactive formulations
   contain at least five free sugars, four organic acids, four phenolic
   compounds and two tocopherols. The fruiting body-based formulation
   revealed higher reducing power, DPPH scavenging activity, beta-carotene
   bleaching inhibition and lipid peroxidation inhibition in brain
   homogenates than the mycelium-based preparation, as well as higher
   anti-inflammatory and antimicrobial activities. The absence of
   hepatotoxicity was confirmed in porcine liver primary cells. These
   functional responses can be related to the levels of bioactive
   components including phenolic acids, organic acids and tocopherols.",
journal = "Food & Function",
title = "Bioactive formulations prepared from fruiting bodies and submerged
 culture mycelia of the Brazilian edible mushroom Pleurotus
 ostreatoroseus Singer",
number = "7",
volume = "6",
doi = "10.1039/c5fo00465a",
pages = "2155-2164"
}
Gomes Correa, R. C., Henrique Pereira de Souza, A., Calhelha, R. C., Barros, L., Glamočlija, J., Soković, M., Peralta, R. M., Bracht, A.,& Ferreira, I. C. F. R.. (2015). Bioactive formulations prepared from fruiting bodies and submerged
 culture mycelia of the Brazilian edible mushroom Pleurotus
 ostreatoroseus Singer. in Food & Function, 6(7), 2155-2164.
https://doi.org/10.1039/c5fo00465a
Gomes Correa RC, Henrique Pereira de Souza A, Calhelha RC, Barros L, Glamočlija J, Soković M, Peralta RM, Bracht A, Ferreira ICFR. Bioactive formulations prepared from fruiting bodies and submerged
 culture mycelia of the Brazilian edible mushroom Pleurotus
 ostreatoroseus Singer. in Food & Function. 2015;6(7):2155-2164.
doi:10.1039/c5fo00465a .
Gomes Correa, Rubia Carvalho, Henrique Pereira de Souza, Aloisio, Calhelha, Ricardo C., Barros, Lillian, Glamočlija, Jasmina, Soković, Marina, Peralta, Rosane Marina, Bracht, Adelar, Ferreira, Isabel C. F. R., "Bioactive formulations prepared from fruiting bodies and submerged
 culture mycelia of the Brazilian edible mushroom Pleurotus
 ostreatoroseus Singer" in Food & Function, 6, no. 7 (2015):2155-2164,
https://doi.org/10.1039/c5fo00465a . .
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