TY  - CONF
AU  - Krajnović, Tamara
AU  - Maksimović-Ivanić, Danijela
AU  - Mijatović, Sanja
AU  - Wessjohann, Ludger A.
AU  - Kaluđerović, Goran N.
PY  - 2022
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5289
AB  - Prenylflavonoid from hops - xanthohumol (XN) has been shown to possess diverse biological properties, including strong anticancer activity. One of the possibilities for improving delivery and effectiveness of drugs is the use of mesoporous silica nanoparticles such as nontoxic SBA-15. The aim of this study was the evaluation of the in vitro anticancer potential of XN loaded with different amounts into SBA-15 particles against malignant mouse melanoma B16-F10 cells. Our data indicate that SBA-15 containing XN showed a loading rate–activity dependence. Importantly, immobilization of XN into SBA-15 preserved and even potentiated its antitumor potential, in comparison to its free form. Also, by loading into SBA-15 carrier, XNs’ anticancer mode of action converted from predominantly cytotoxic to cytostatic, resulting in a reduction of dividing potential. In addition, contrasting the previously observed apoptotic-inducing property of free XN, immobilized XN induced autophagic cell death that might be important for disabling tumor repopulation in response to apoptotic-induced cell proliferation, a mechanism often asscociated with therapy failure of advanced forms of cancer1.
PB  - Belgrade: Faculty of Chemistry
C3  - Proceedings: Serbian Biochemical Society, Eleventh Conference, Scientific meeting of an international character: "Amazing Biochemistry"; 2022 Sep 22-23; Novi Sad, Serbia
T1  - Anticancer potential of xanthohumol loaded into SBA-15 mesoporous silica particles against B16-F10 cells
SP  - 87
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5289
ER  - 

@conference{
author = "Krajnović, Tamara and Maksimović-Ivanić, Danijela and Mijatović, Sanja and Wessjohann, Ludger A. and Kaluđerović, Goran N.",
year = "2022",
abstract = "Prenylflavonoid from hops - xanthohumol (XN) has been shown to possess diverse biological properties, including strong anticancer activity. One of the possibilities for improving delivery and effectiveness of drugs is the use of mesoporous silica nanoparticles such as nontoxic SBA-15. The aim of this study was the evaluation of the in vitro anticancer potential of XN loaded with different amounts into SBA-15 particles against malignant mouse melanoma B16-F10 cells. Our data indicate that SBA-15 containing XN showed a loading rate–activity dependence. Importantly, immobilization of XN into SBA-15 preserved and even potentiated its antitumor potential, in comparison to its free form. Also, by loading into SBA-15 carrier, XNs’ anticancer mode of action converted from predominantly cytotoxic to cytostatic, resulting in a reduction of dividing potential. In addition, contrasting the previously observed apoptotic-inducing property of free XN, immobilized XN induced autophagic cell death that might be important for disabling tumor repopulation in response to apoptotic-induced cell proliferation, a mechanism often asscociated with therapy failure of advanced forms of cancer1.",
publisher = "Belgrade: Faculty of Chemistry",
journal = "Proceedings: Serbian Biochemical Society, Eleventh Conference, Scientific meeting of an international character: "Amazing Biochemistry"; 2022 Sep 22-23; Novi Sad, Serbia",
title = "Anticancer potential of xanthohumol loaded into SBA-15 mesoporous silica particles against B16-F10 cells",
pages = "87",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5289"
}

Krajnović, T., Maksimović-Ivanić, D., Mijatović, S., Wessjohann, L. A.,& Kaluđerović, G. N.. (2022). Anticancer potential of xanthohumol loaded into SBA-15 mesoporous silica particles against B16-F10 cells. in Proceedings: Serbian Biochemical Society, Eleventh Conference, Scientific meeting of an international character: "Amazing Biochemistry"; 2022 Sep 22-23; Novi Sad, Serbia
Belgrade: Faculty of Chemistry., 87.
https://hdl.handle.net/21.15107/rcub_ibiss_5289

Krajnović T, Maksimović-Ivanić D, Mijatović S, Wessjohann LA, Kaluđerović GN. Anticancer potential of xanthohumol loaded into SBA-15 mesoporous silica particles against B16-F10 cells. in Proceedings: Serbian Biochemical Society, Eleventh Conference, Scientific meeting of an international character: "Amazing Biochemistry"; 2022 Sep 22-23; Novi Sad, Serbia. 2022;:87.
https://hdl.handle.net/21.15107/rcub_ibiss_5289 .

Krajnović, Tamara, Maksimović-Ivanić, Danijela, Mijatović, Sanja, Wessjohann, Ludger A., Kaluđerović, Goran N., "Anticancer potential of xanthohumol loaded into SBA-15 mesoporous silica particles against B16-F10 cells" in Proceedings: Serbian Biochemical Society, Eleventh Conference, Scientific meeting of an international character: "Amazing Biochemistry"; 2022 Sep 22-23; Novi Sad, Serbia (2022):87,
https://hdl.handle.net/21.15107/rcub_ibiss_5289 .

TY  - CONF
AU  - Mihajlović, Ekatarina
AU  - Drača, Dijana
AU  - Komazec, Teodora
AU  - Mijatović, Sanja
AU  - Predarska, Ivana
AU  - Kaluđerović, Goran N.
AU  - Hey-Hawkins, Evamarie
AU  - Maksimović-Ivanić, Danijela
PY  - 2022
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5287
AB  - To develop anticancer drugs with higher activity and reduced toxicity, cisplatin was used as a scaffold to bear the anti-inflammatory drug naproxen and this conjugate was loaded into silica nanoparticles, SBA-15. In this study, the cytotoxic effect of the free conjugate and the one loaded in SBA-15 was evaluated on different cancer cell lines of mouse origin (B16, 4T1, CT26 and MC38). Treatment with free, as well as with SBA-15-bound conjugate, dose-dependently decreased viability of all cancer cell lines. The viability decrease of B16 cells after treatment with both agents was not caused by apoptosis, but it was followed by caspase activation. On the other hand, treatment with both agents caused significant decrease of B16 cells division rate, indicating the primary cytostatic effect of these agents. Additionally, it was shown that treatment with the free conjugate caused intensified autophagy, while the conjugate loaded into SBA-15 did not show this effect. Since the viability of cells recovered upon the exposure to 3-methyl adenine, detected autophagy serves as a cell death mechanism. Overall, these results indicate that both nacked and immobilized conjugates show great potential for cancer treatment.
PB  - Belgrade: Faculty of Chemistry
C3  - Proceedings: Serbian Biochemical Society, Eleventh Conference, Scientific meeting of an international character: "Amazing Biochemistry"; 2022 Sep 22-23; Novi Sad, Serbia
T1  - Anticancer properties of cisplatin-naproxen conjugate: free and loaded in SBA-15
SP  - 99
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5287
ER  - 

@conference{
author = "Mihajlović, Ekatarina and Drača, Dijana and Komazec, Teodora and Mijatović, Sanja and Predarska, Ivana and Kaluđerović, Goran N. and Hey-Hawkins, Evamarie and Maksimović-Ivanić, Danijela",
year = "2022",
abstract = "To develop anticancer drugs with higher activity and reduced toxicity, cisplatin was used as a scaffold to bear the anti-inflammatory drug naproxen and this conjugate was loaded into silica nanoparticles, SBA-15. In this study, the cytotoxic effect of the free conjugate and the one loaded in SBA-15 was evaluated on different cancer cell lines of mouse origin (B16, 4T1, CT26 and MC38). Treatment with free, as well as with SBA-15-bound conjugate, dose-dependently decreased viability of all cancer cell lines. The viability decrease of B16 cells after treatment with both agents was not caused by apoptosis, but it was followed by caspase activation. On the other hand, treatment with both agents caused significant decrease of B16 cells division rate, indicating the primary cytostatic effect of these agents. Additionally, it was shown that treatment with the free conjugate caused intensified autophagy, while the conjugate loaded into SBA-15 did not show this effect. Since the viability of cells recovered upon the exposure to 3-methyl adenine, detected autophagy serves as a cell death mechanism. Overall, these results indicate that both nacked and immobilized conjugates show great potential for cancer treatment.",
publisher = "Belgrade: Faculty of Chemistry",
journal = "Proceedings: Serbian Biochemical Society, Eleventh Conference, Scientific meeting of an international character: "Amazing Biochemistry"; 2022 Sep 22-23; Novi Sad, Serbia",
title = "Anticancer properties of cisplatin-naproxen conjugate: free and loaded in SBA-15",
pages = "99",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5287"
}

Mihajlović, E., Drača, D., Komazec, T., Mijatović, S., Predarska, I., Kaluđerović, G. N., Hey-Hawkins, E.,& Maksimović-Ivanić, D.. (2022). Anticancer properties of cisplatin-naproxen conjugate: free and loaded in SBA-15. in Proceedings: Serbian Biochemical Society, Eleventh Conference, Scientific meeting of an international character: "Amazing Biochemistry"; 2022 Sep 22-23; Novi Sad, Serbia
Belgrade: Faculty of Chemistry., 99.
https://hdl.handle.net/21.15107/rcub_ibiss_5287

Mihajlović E, Drača D, Komazec T, Mijatović S, Predarska I, Kaluđerović GN, Hey-Hawkins E, Maksimović-Ivanić D. Anticancer properties of cisplatin-naproxen conjugate: free and loaded in SBA-15. in Proceedings: Serbian Biochemical Society, Eleventh Conference, Scientific meeting of an international character: "Amazing Biochemistry"; 2022 Sep 22-23; Novi Sad, Serbia. 2022;:99.
https://hdl.handle.net/21.15107/rcub_ibiss_5287 .

Mihajlović, Ekatarina, Drača, Dijana, Komazec, Teodora, Mijatović, Sanja, Predarska, Ivana, Kaluđerović, Goran N., Hey-Hawkins, Evamarie, Maksimović-Ivanić, Danijela, "Anticancer properties of cisplatin-naproxen conjugate: free and loaded in SBA-15" in Proceedings: Serbian Biochemical Society, Eleventh Conference, Scientific meeting of an international character: "Amazing Biochemistry"; 2022 Sep 22-23; Novi Sad, Serbia (2022):99,
https://hdl.handle.net/21.15107/rcub_ibiss_5287 .

TY  - JOUR
AU  - Krajnović, Tamara
AU  - Drača, Dijana
AU  - Kaluđerović, Goran
AU  - Dunđerović, Duško
AU  - Mirkov, Ivana
AU  - Wessjohann, Ludger A.
AU  - Maksimović-Ivanić, Danijela
AU  - Mijatović, Sanja
PY  - 2019
UR  - https://www.sciencedirect.com/science/article/pii/S0278691519302455?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3350
AB  - Isoxanthohumol (IXN), a prenylflavonoid from hops and beer, gained increasing attention as a potential chemopreventive agent. In the present study, IXN antimetastatic potential in vitro against the highly invasive melanoma cell line B16-F10 and in vivo in a murine metastatic model was investigated. Melanoma cell viability was diminished in a dose-dependent manner following the treatment with IXN. This decrease was a consequence of autophagy and caspase-dependent apoptosis. Additionally, the dividing potential of highly proliferative melanoma cells was dramatically affected by this isoflavanone, which was in correlation with an abrogated cell colony forming potential, indicating changes in their metastatic features. Concordantly, IXN promoted strong suppression of the processes that define metastasis- cell adhesion, invasion, and migration. Further investigation at the molecular level revealed that the abolished metastatic potential of a melanoma subclone was due to disrupted integrin signaling. Importantly, these results were reaffirmed in vivo where IXN inhibited the development of lung metastatic foci in tumor-challenged animals. The results of the present study may highlight the beneficial effects of IXN on melanoma as the most aggressive type of skin cancer and will hopefully shed a light on the possible use of this prenylflavonoid in the treatment of metastatic malignancies.
T2  - Food and Chemical Toxicology
T1  - The hop-derived prenylflavonoid isoxanthohumol inhibits the formation of lung metastasis in B16-F10 murine melanoma model.
VL  - 129
DO  - 10.1016/j.fct.2019.04.046
SP  - 257
EP  - 268
ER  - 

@article{
author = "Krajnović, Tamara and Drača, Dijana and Kaluđerović, Goran and Dunđerović, Duško and Mirkov, Ivana and Wessjohann, Ludger A. and Maksimović-Ivanić, Danijela and Mijatović, Sanja",
year = "2019",
abstract = "Isoxanthohumol (IXN), a prenylflavonoid from hops and beer, gained increasing attention as a potential chemopreventive agent. In the present study, IXN antimetastatic potential in vitro against the highly invasive melanoma cell line B16-F10 and in vivo in a murine metastatic model was investigated. Melanoma cell viability was diminished in a dose-dependent manner following the treatment with IXN. This decrease was a consequence of autophagy and caspase-dependent apoptosis. Additionally, the dividing potential of highly proliferative melanoma cells was dramatically affected by this isoflavanone, which was in correlation with an abrogated cell colony forming potential, indicating changes in their metastatic features. Concordantly, IXN promoted strong suppression of the processes that define metastasis- cell adhesion, invasion, and migration. Further investigation at the molecular level revealed that the abolished metastatic potential of a melanoma subclone was due to disrupted integrin signaling. Importantly, these results were reaffirmed in vivo where IXN inhibited the development of lung metastatic foci in tumor-challenged animals. The results of the present study may highlight the beneficial effects of IXN on melanoma as the most aggressive type of skin cancer and will hopefully shed a light on the possible use of this prenylflavonoid in the treatment of metastatic malignancies.",
journal = "Food and Chemical Toxicology",
title = "The hop-derived prenylflavonoid isoxanthohumol inhibits the formation of lung metastasis in B16-F10 murine melanoma model.",
volume = "129",
doi = "10.1016/j.fct.2019.04.046",
pages = "257-268"
}

Krajnović, T., Drača, D., Kaluđerović, G., Dunđerović, D., Mirkov, I., Wessjohann, L. A., Maksimović-Ivanić, D.,& Mijatović, S.. (2019). The hop-derived prenylflavonoid isoxanthohumol inhibits the formation of lung metastasis in B16-F10 murine melanoma model.. in Food and Chemical Toxicology, 129, 257-268.
https://doi.org/10.1016/j.fct.2019.04.046

Krajnović T, Drača D, Kaluđerović G, Dunđerović D, Mirkov I, Wessjohann LA, Maksimović-Ivanić D, Mijatović S. The hop-derived prenylflavonoid isoxanthohumol inhibits the formation of lung metastasis in B16-F10 murine melanoma model.. in Food and Chemical Toxicology. 2019;129:257-268.
doi:10.1016/j.fct.2019.04.046 .

Krajnović, Tamara, Drača, Dijana, Kaluđerović, Goran, Dunđerović, Duško, Mirkov, Ivana, Wessjohann, Ludger A., Maksimović-Ivanić, Danijela, Mijatović, Sanja, "The hop-derived prenylflavonoid isoxanthohumol inhibits the formation of lung metastasis in B16-F10 murine melanoma model." in Food and Chemical Toxicology, 129 (2019):257-268,
https://doi.org/10.1016/j.fct.2019.04.046 . .

TY  - JOUR
AU  - Edeler, David
AU  - Arlt, Sören
AU  - Petković, Vladana
AU  - Ludwig, Gerd
AU  - Drača, Dijana
AU  - Maksimović-Ivanić, Danijela
AU  - Mijatović, Sanja
AU  - Kaluđerović, Goran N.
PY  - 2018
UR  - http://linkinghub.elsevier.com/retrieve/pii/S0162013417306165
UR  - http://www.ncbi.nlm.nih.gov/pubmed/29288894
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2954
AB  - SBA-15 (Santa Barbara Amorphous 15) mesoporous silica and its functionalized form (with 3-mercaptopropyltriethoxysilane) SBA-15~SH were used as carriers for [Ru(η6-p-cymene)Cl2{Ph2P(CH2)3SPh-κP}] complex, denoted as [Ru]. Prepared mesoporous silica nanomaterials were characterized by traditional methods. Materials without [Ru] complex did not show any cytotoxic activity against melanoma B16 and B16-F10 cell lines. On the contrary, materials containing [Ru] such as SBA-15|[Ru] and SBA-15~SH|[Ru], exhibited very high activity against tested tumor cell lines, moreover with similar inhibitory potential. According to the loaded amount of the [Ru] in SBA-15|[Ru] and SBA-15~SH|[Ru] the IC50 values are 1-2μM depending on the test used, thus in comparison to [Ru] alone the activity of nanomaterials containing [Ru] are elevated 3-6 times in vitro. However, the mechanism of apoptosis induction differs for these two mesoporous silica. Unlike reference [Ru] compound and SBA-15~SH|[Ru], SBA-15|[Ru] induces high caspase activation. Discrepancy in mechanism of drugs action at intracellular level points towards an influence of functionalization as well as availability of the drug. Moreover, both SBA-15|[Ru] and SBA-15~SH|[Ru] similarly to [Ru] are declining autophagy in B16 cell line.
T2  - Journal of Inorganic Biochemistry
T1  - Delivery of [Ru(η6-p-cymene)Cl2{Ph2P(CH2)3SPh-κP}] using unfunctionalized and mercapto functionalized SBA-15 mesoporous silica: Preparation, characterization and in vitro study.
VL  - 180
DO  - 10.1016/j.jinorgbio.2017.12.011
SP  - 155
EP  - 162
ER  - 

@article{
author = "Edeler, David and Arlt, Sören and Petković, Vladana and Ludwig, Gerd and Drača, Dijana and Maksimović-Ivanić, Danijela and Mijatović, Sanja and Kaluđerović, Goran N.",
year = "2018",
abstract = "SBA-15 (Santa Barbara Amorphous 15) mesoporous silica and its functionalized form (with 3-mercaptopropyltriethoxysilane) SBA-15~SH were used as carriers for [Ru(η6-p-cymene)Cl2{Ph2P(CH2)3SPh-κP}] complex, denoted as [Ru]. Prepared mesoporous silica nanomaterials were characterized by traditional methods. Materials without [Ru] complex did not show any cytotoxic activity against melanoma B16 and B16-F10 cell lines. On the contrary, materials containing [Ru] such as SBA-15|[Ru] and SBA-15~SH|[Ru], exhibited very high activity against tested tumor cell lines, moreover with similar inhibitory potential. According to the loaded amount of the [Ru] in SBA-15|[Ru] and SBA-15~SH|[Ru] the IC50 values are 1-2μM depending on the test used, thus in comparison to [Ru] alone the activity of nanomaterials containing [Ru] are elevated 3-6 times in vitro. However, the mechanism of apoptosis induction differs for these two mesoporous silica. Unlike reference [Ru] compound and SBA-15~SH|[Ru], SBA-15|[Ru] induces high caspase activation. Discrepancy in mechanism of drugs action at intracellular level points towards an influence of functionalization as well as availability of the drug. Moreover, both SBA-15|[Ru] and SBA-15~SH|[Ru] similarly to [Ru] are declining autophagy in B16 cell line.",
journal = "Journal of Inorganic Biochemistry",
title = "Delivery of [Ru(η6-p-cymene)Cl2{Ph2P(CH2)3SPh-κP}] using unfunctionalized and mercapto functionalized SBA-15 mesoporous silica: Preparation, characterization and in vitro study.",
volume = "180",
doi = "10.1016/j.jinorgbio.2017.12.011",
pages = "155-162"
}

Edeler, D., Arlt, S., Petković, V., Ludwig, G., Drača, D., Maksimović-Ivanić, D., Mijatović, S.,& Kaluđerović, G. N.. (2018). Delivery of [Ru(η6-p-cymene)Cl2{Ph2P(CH2)3SPh-κP}] using unfunctionalized and mercapto functionalized SBA-15 mesoporous silica: Preparation, characterization and in vitro study.. in Journal of Inorganic Biochemistry, 180, 155-162.
https://doi.org/10.1016/j.jinorgbio.2017.12.011

Edeler D, Arlt S, Petković V, Ludwig G, Drača D, Maksimović-Ivanić D, Mijatović S, Kaluđerović GN. Delivery of [Ru(η6-p-cymene)Cl2{Ph2P(CH2)3SPh-κP}] using unfunctionalized and mercapto functionalized SBA-15 mesoporous silica: Preparation, characterization and in vitro study.. in Journal of Inorganic Biochemistry. 2018;180:155-162.
doi:10.1016/j.jinorgbio.2017.12.011 .

Edeler, David, Arlt, Sören, Petković, Vladana, Ludwig, Gerd, Drača, Dijana, Maksimović-Ivanić, Danijela, Mijatović, Sanja, Kaluđerović, Goran N., "Delivery of [Ru(η6-p-cymene)Cl2{Ph2P(CH2)3SPh-κP}] using unfunctionalized and mercapto functionalized SBA-15 mesoporous silica: Preparation, characterization and in vitro study." in Journal of Inorganic Biochemistry, 180 (2018):155-162,
https://doi.org/10.1016/j.jinorgbio.2017.12.011 . .

TY  - JOUR
AU  - Kaluđerović, Goran
AU  - Bulatović, Mirna
AU  - Krajnović, Tamara
AU  - Paschke, Reinhard
AU  - B. Zmejkovski, Bojana
AU  - Maksimović-Ivanić, Danijela
AU  - Mijatović, Sanja
PY  - 2017
UR  - http://www.mdpi.com/2304-6740/5/3/56
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3042
AB  - Synthesis of platinum(II) conjugate with acetylated betulinic acid tris(hydroxymethyl)aminomethane ester (BATRIS) is presented (BATRISPt). HR-ESI-MS and multinuclear NMR spectroscopy, as well as elemental analysis were used for characterization of BATRISPt. Cytotoxicity (3-(4,5-dimethythiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), crystal violet (CV), and sulforhodamine B (SRB) assays) of BA, BATRIS, BATRISPt, and cisplatin were assessed on seven different tumor cell lines: melanoma B16, colon HCT116 and DLD-1, adenocarcinoma HeLa, breast MCF-7, and anaplastic thyroid tumor 8505C and SW1736; as well as normal MRC-5 fibroblasts. Furthermore, the effect of the mentioned compounds on the apoptosis (Annexin V/PI assay) and autophagy induction (acridine orange (AO) assay) as well as caspase 3, 8, and 9 activation were investigated on the selected B16 melanoma cell line. BATRISPt showed lower activity than BA, BATRIS, or cisplatin. All tested compounds triggered apoptosis in B16 cells. Induction of autophagy was observed in B16 cells exposed only to BATRIS. On the other hand, new conjugate activates caspases 8 and 9 in B16 cells with higher impact than BATRIS or cisplatin alone.
T2  - Inorganics
T1  - (18-Crown-6)potassium(I) Trichlorido[28-acetyl-3-(tris-(hydroxylmethyl)amino-ethane)betulinic ester-κN]platinum(II): Synthesis and In Vitro Antitumor Activity
IS  - 3
VL  - 5
DO  - 10.3390/inorganics5030056
SP  - 56
ER  - 

@article{
author = "Kaluđerović, Goran and Bulatović, Mirna and Krajnović, Tamara and Paschke, Reinhard and B. Zmejkovski, Bojana and Maksimović-Ivanić, Danijela and Mijatović, Sanja",
year = "2017",
abstract = "Synthesis of platinum(II) conjugate with acetylated betulinic acid tris(hydroxymethyl)aminomethane ester (BATRIS) is presented (BATRISPt). HR-ESI-MS and multinuclear NMR spectroscopy, as well as elemental analysis were used for characterization of BATRISPt. Cytotoxicity (3-(4,5-dimethythiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), crystal violet (CV), and sulforhodamine B (SRB) assays) of BA, BATRIS, BATRISPt, and cisplatin were assessed on seven different tumor cell lines: melanoma B16, colon HCT116 and DLD-1, adenocarcinoma HeLa, breast MCF-7, and anaplastic thyroid tumor 8505C and SW1736; as well as normal MRC-5 fibroblasts. Furthermore, the effect of the mentioned compounds on the apoptosis (Annexin V/PI assay) and autophagy induction (acridine orange (AO) assay) as well as caspase 3, 8, and 9 activation were investigated on the selected B16 melanoma cell line. BATRISPt showed lower activity than BA, BATRIS, or cisplatin. All tested compounds triggered apoptosis in B16 cells. Induction of autophagy was observed in B16 cells exposed only to BATRIS. On the other hand, new conjugate activates caspases 8 and 9 in B16 cells with higher impact than BATRIS or cisplatin alone.",
journal = "Inorganics",
title = "(18-Crown-6)potassium(I) Trichlorido[28-acetyl-3-(tris-(hydroxylmethyl)amino-ethane)betulinic ester-κN]platinum(II): Synthesis and In Vitro Antitumor Activity",
number = "3",
volume = "5",
doi = "10.3390/inorganics5030056",
pages = "56"
}

Kaluđerović, G., Bulatović, M., Krajnović, T., Paschke, R., B. Zmejkovski, B., Maksimović-Ivanić, D.,& Mijatović, S.. (2017). (18-Crown-6)potassium(I) Trichlorido[28-acetyl-3-(tris-(hydroxylmethyl)amino-ethane)betulinic ester-κN]platinum(II): Synthesis and In Vitro Antitumor Activity. in Inorganics, 5(3), 56.
https://doi.org/10.3390/inorganics5030056

Kaluđerović G, Bulatović M, Krajnović T, Paschke R, B. Zmejkovski B, Maksimović-Ivanić D, Mijatović S. (18-Crown-6)potassium(I) Trichlorido[28-acetyl-3-(tris-(hydroxylmethyl)amino-ethane)betulinic ester-κN]platinum(II): Synthesis and In Vitro Antitumor Activity. in Inorganics. 2017;5(3):56.
doi:10.3390/inorganics5030056 .

Kaluđerović, Goran, Bulatović, Mirna, Krajnović, Tamara, Paschke, Reinhard, B. Zmejkovski, Bojana, Maksimović-Ivanić, Danijela, Mijatović, Sanja, "(18-Crown-6)potassium(I) Trichlorido[28-acetyl-3-(tris-(hydroxylmethyl)amino-ethane)betulinic ester-κN]platinum(II): Synthesis and In Vitro Antitumor Activity" in Inorganics, 5, no. 3 (2017):56,
https://doi.org/10.3390/inorganics5030056 . .

TY  - JOUR
AU  - Janković Tomanić, Milena
AU  - Todorović, Dajana
AU  - Stanivuković, Zoran
AU  - Perić Mataruga, Vesna
AU  - Wessjohann, Ludger A.
AU  - Kaluđerović, Goran N.
PY  - 2017
UR  - http://online.journals.tubitak.gov.tr/openDoiPdf.htm?mKodu=biy-1705-76
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2945
AB  - The study presented here aims to elucidate the effects of emodin (EO = 1,3,8-trihydroxy-6-methylanthraquinone) in its free form and when loaded into a mesoporous silica nanocarrier SBA-15 (→ SBA-15|EO) on the activities of the main antioxidative enzymes, superoxide dismutase, catalase, glutathione S-transferase, and glutathione reductase, in larvae of a polyphagous insect pest, the browntail moth Euproctis chrysorrhoea (L.). The results show that only SBA-15|EO upregulates the activities of the tested antioxidative enzymes. These results point to significant differences in the effectiveness of the compound in the free versus the loaded form.
PB  - Scientific and Technical Research Council of Turkey
T2  - Turkish Journal of Biology
T2  - Turkish Journal of Biology
T1  - Mesoporous silica nanoparticles SBA-15 loaded with emodin upregulate the antioxidative defense of Euproctis chrysorrhoea (L.) larvae
IS  - 6
VL  - 41
DO  - 10.3906/biy-1705-76
SP  - 935
EP  - 942
ER  - 

@article{
author = "Janković Tomanić, Milena and Todorović, Dajana and Stanivuković, Zoran and Perić Mataruga, Vesna and Wessjohann, Ludger A. and Kaluđerović, Goran N.",
year = "2017",
abstract = "The study presented here aims to elucidate the effects of emodin (EO = 1,3,8-trihydroxy-6-methylanthraquinone) in its free form and when loaded into a mesoporous silica nanocarrier SBA-15 (→ SBA-15|EO) on the activities of the main antioxidative enzymes, superoxide dismutase, catalase, glutathione S-transferase, and glutathione reductase, in larvae of a polyphagous insect pest, the browntail moth Euproctis chrysorrhoea (L.). The results show that only SBA-15|EO upregulates the activities of the tested antioxidative enzymes. These results point to significant differences in the effectiveness of the compound in the free versus the loaded form.",
publisher = "Scientific and Technical Research Council of Turkey",
journal = "Turkish Journal of Biology, Turkish Journal of Biology",
title = "Mesoporous silica nanoparticles SBA-15 loaded with emodin upregulate the antioxidative defense of Euproctis chrysorrhoea (L.) larvae",
number = "6",
volume = "41",
doi = "10.3906/biy-1705-76",
pages = "935-942"
}

Janković Tomanić, M., Todorović, D., Stanivuković, Z., Perić Mataruga, V., Wessjohann, L. A.,& Kaluđerović, G. N.. (2017). Mesoporous silica nanoparticles SBA-15 loaded with emodin upregulate the antioxidative defense of Euproctis chrysorrhoea (L.) larvae. in Turkish Journal of Biology
Scientific and Technical Research Council of Turkey., 41(6), 935-942.
https://doi.org/10.3906/biy-1705-76

Janković Tomanić M, Todorović D, Stanivuković Z, Perić Mataruga V, Wessjohann LA, Kaluđerović GN. Mesoporous silica nanoparticles SBA-15 loaded with emodin upregulate the antioxidative defense of Euproctis chrysorrhoea (L.) larvae. in Turkish Journal of Biology. 2017;41(6):935-942.
doi:10.3906/biy-1705-76 .

Janković Tomanić, Milena, Todorović, Dajana, Stanivuković, Zoran, Perić Mataruga, Vesna, Wessjohann, Ludger A., Kaluđerović, Goran N., "Mesoporous silica nanoparticles SBA-15 loaded with emodin upregulate the antioxidative defense of Euproctis chrysorrhoea (L.) larvae" in Turkish Journal of Biology, 41, no. 6 (2017):935-942,
https://doi.org/10.3906/biy-1705-76 . .

TY  - JOUR
AU  - Bensing, Christian
AU  - Mojić, Marija
AU  - Gómez-Ruiz, Santiago
AU  - Carralero, Sandra
AU  - Dojčinović, Biljana
AU  - Maksimović-Ivanić, Danijela
AU  - Mijatović, Sanja
AU  - Kaluđerović, Goran N.
PY  - 2016
UR  - http://xlink.rsc.org/?DOI=C6DT03519A
UR  - https://www.scopus.com/record/display.uri?eid=2-s2.0-85000774313&origin=SingleRecordEmailAlert&dgcid=scalert_sc_search_email&txGid=691E27A4B52E4CB98111082A19AFDEEC.wsnAw8kcdt7IPYLO0V48gA%3A11#
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2481
AB  - SBA-15|Sn3, a mesoporous silica-based material (derivative of SBA-15) loaded with an organotin compound Ph3Sn(CH2)3OH (Sn3), possesses improved antitumor potential against the A2780 high-grade serous ovarian carcinoma cell line in comparison to Sn3. It is demonstrated that both the compound and the nanostructured material are internalized by the A2780 cells. A similar mode of action of Sn3 and SBA-15|Sn3 against the A2780 cell line was found. Explicitly, induction of apoptosis, caspase 2, 3, 8 and 9 activation, accumulation of cells in the hypodiploid phase as well as accumulation of ROS were observed. Interestingly, Sn3 loaded in the mesoporous silica-based material needed to reach a concentration 3.5 times lower than the IC50 value of the Sn3 compound, pointing out a higher effect of the SBA-15|Sn3 than Sn3 alone. Clonogenic potential, growth in 3D culture as well as mobility of cells were disturbed in the presence of SBA-15|Sn3. Such behavior could be associated with the suppression of p-38 MAPK. Less profound effect of Sn3 compared to SBA-15|Sn3 could be attributed to a different regulation of p-38 and STAT-3, which are mainly responsible for an appropriate cellular response to diverse stimuli or metastatic properties.
T2  - Dalton Transactions
T1  - Evaluation of functionalized mesoporous silica SBA-15 as a carrier system for Ph 3 Sn(CH 2) 3 OH against the A2780 ovarian carcinoma cell line
IS  - 47
VL  - 45
DO  - 10.1039/C6DT03519A
SP  - 18984
EP  - 18993
ER  - 

@article{
author = "Bensing, Christian and Mojić, Marija and Gómez-Ruiz, Santiago and Carralero, Sandra and Dojčinović, Biljana and Maksimović-Ivanić, Danijela and Mijatović, Sanja and Kaluđerović, Goran N.",
year = "2016",
abstract = "SBA-15|Sn3, a mesoporous silica-based material (derivative of SBA-15) loaded with an organotin compound Ph3Sn(CH2)3OH (Sn3), possesses improved antitumor potential against the A2780 high-grade serous ovarian carcinoma cell line in comparison to Sn3. It is demonstrated that both the compound and the nanostructured material are internalized by the A2780 cells. A similar mode of action of Sn3 and SBA-15|Sn3 against the A2780 cell line was found. Explicitly, induction of apoptosis, caspase 2, 3, 8 and 9 activation, accumulation of cells in the hypodiploid phase as well as accumulation of ROS were observed. Interestingly, Sn3 loaded in the mesoporous silica-based material needed to reach a concentration 3.5 times lower than the IC50 value of the Sn3 compound, pointing out a higher effect of the SBA-15|Sn3 than Sn3 alone. Clonogenic potential, growth in 3D culture as well as mobility of cells were disturbed in the presence of SBA-15|Sn3. Such behavior could be associated with the suppression of p-38 MAPK. Less profound effect of Sn3 compared to SBA-15|Sn3 could be attributed to a different regulation of p-38 and STAT-3, which are mainly responsible for an appropriate cellular response to diverse stimuli or metastatic properties.",
journal = "Dalton Transactions",
title = "Evaluation of functionalized mesoporous silica SBA-15 as a carrier system for Ph 3 Sn(CH 2) 3 OH against the A2780 ovarian carcinoma cell line",
number = "47",
volume = "45",
doi = "10.1039/C6DT03519A",
pages = "18984-18993"
}

Bensing, C., Mojić, M., Gómez-Ruiz, S., Carralero, S., Dojčinović, B., Maksimović-Ivanić, D., Mijatović, S.,& Kaluđerović, G. N.. (2016). Evaluation of functionalized mesoporous silica SBA-15 as a carrier system for Ph 3 Sn(CH 2) 3 OH against the A2780 ovarian carcinoma cell line. in Dalton Transactions, 45(47), 18984-18993.
https://doi.org/10.1039/C6DT03519A

Bensing C, Mojić M, Gómez-Ruiz S, Carralero S, Dojčinović B, Maksimović-Ivanić D, Mijatović S, Kaluđerović GN. Evaluation of functionalized mesoporous silica SBA-15 as a carrier system for Ph 3 Sn(CH 2) 3 OH against the A2780 ovarian carcinoma cell line. in Dalton Transactions. 2016;45(47):18984-18993.
doi:10.1039/C6DT03519A .

Bensing, Christian, Mojić, Marija, Gómez-Ruiz, Santiago, Carralero, Sandra, Dojčinović, Biljana, Maksimović-Ivanić, Danijela, Mijatović, Sanja, Kaluđerović, Goran N., "Evaluation of functionalized mesoporous silica SBA-15 as a carrier system for Ph 3 Sn(CH 2) 3 OH against the A2780 ovarian carcinoma cell line" in Dalton Transactions, 45, no. 47 (2016):18984-18993,
https://doi.org/10.1039/C6DT03519A . .

TY  - JOUR
AU  - Momčilović, Miljana
AU  - Eichhorn, Thomas
AU  - Blaževski, Jana
AU  - Schmidt, Harry
AU  - Kaluđerović, Goran N.
AU  - Stošić-Grujičić, Stanislava
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1979
AB  - T cell differentiation into distinct T helper (Th) subpopulations is
   crucial in governing acquired immune responses as well as some
   inflammatory and autoimmune disorders. This study investigated potential
   of the novel neutral binuclear ruthenium(II) complexes 1-8 with general
   formula {[}\{RuCl2(eta(6)-p-cym)\}(2)mu-((NN)-N-a (c))] ((NN)-N-a (c) =
   bis(nicotinate)- and bis(iso-nicotinate)-polyethylene glycol esters;
   (3-py)COO(CH2CH2O) (n) CO(3-py) and (4-py)COO(CH2CH2O) (n) CO(4-py); n =
   1-4), as well as {[}RuCl2(eta(6)-p-cym)(nic)] (R1, nic = nicotinate) and
   {[}RuCl2(eta(6)-p-cym)(inic)] (R2, inic = isonicotinate) as an
   immunomodulatory agents capable to direct Th cell differentiation. From
   all investigated complexes,
   {[}\{RuCl2(eta(6)-p-cym)\}(2)mu-\{(3-py)COO(CH2CH2O)(4)CO(3-py)\}] (4)
   was selected for further study because it did not affect splenocyte
   viability (in concentration up to 50 mu M), but significantly reduced
   secretion of representative Th1 cytokine, IFN-gamma induced by T cell
   mitogen. Besides IFN-gamma, 4 inhibited dose dependently expression and
   production of representative Th17 cytokine, IL-17, in these cells.
   Otherwise, the production of anti-inflammatory cytokines IL-4 and IL-10
   was upregulated. Also, 4 significantly increased CD4(+)CD25(+)FoxP3(+)
   Treg cell frequency in the activated splenocytes. Moreover, ConA-induced
   expression of Th1 transcription factors, T-bet and STAT1, as well as of
   Th17-related protein STAT3 was attenuated upon exposure to 4, while the
   expression of Th2-related transcription factor GATA3 remained stable. In
   conclusion, ruthenium(II) complex 4 modulates immune system cell
   functions in vitro by inhibiting T cell differentiation towards
   pathogenic Th1/Th17 phenotype and inducing a regulatory phenotype
   characterized by IL-10 and IL-4 production, which may provide novel
   therapeutic opportunities for immune-inflammatory and/or autoimmune
   disorders.
T2  - Journal of Biological Inorganic Chemistry
T1  - In vitro effects of binuclear (eta (6)-p-cymene)ruthenium(II) complex
 containing bridging bis(nicotinate)-polyethylene glycol ester ligand on
 differentiation pathways of murine Th lymphocytes activated by T cell
 mitogen
IS  - 3
VL  - 20
DO  - 10.1007/s00775-015-1242-x
SP  - 575
EP  - 583
ER  - 

@article{
author = "Momčilović, Miljana and Eichhorn, Thomas and Blaževski, Jana and Schmidt, Harry and Kaluđerović, Goran N. and Stošić-Grujičić, Stanislava",
year = "2015",
abstract = "T cell differentiation into distinct T helper (Th) subpopulations is
   crucial in governing acquired immune responses as well as some
   inflammatory and autoimmune disorders. This study investigated potential
   of the novel neutral binuclear ruthenium(II) complexes 1-8 with general
   formula {[}\{RuCl2(eta(6)-p-cym)\}(2)mu-((NN)-N-a (c))] ((NN)-N-a (c) =
   bis(nicotinate)- and bis(iso-nicotinate)-polyethylene glycol esters;
   (3-py)COO(CH2CH2O) (n) CO(3-py) and (4-py)COO(CH2CH2O) (n) CO(4-py); n =
   1-4), as well as {[}RuCl2(eta(6)-p-cym)(nic)] (R1, nic = nicotinate) and
   {[}RuCl2(eta(6)-p-cym)(inic)] (R2, inic = isonicotinate) as an
   immunomodulatory agents capable to direct Th cell differentiation. From
   all investigated complexes,
   {[}\{RuCl2(eta(6)-p-cym)\}(2)mu-\{(3-py)COO(CH2CH2O)(4)CO(3-py)\}] (4)
   was selected for further study because it did not affect splenocyte
   viability (in concentration up to 50 mu M), but significantly reduced
   secretion of representative Th1 cytokine, IFN-gamma induced by T cell
   mitogen. Besides IFN-gamma, 4 inhibited dose dependently expression and
   production of representative Th17 cytokine, IL-17, in these cells.
   Otherwise, the production of anti-inflammatory cytokines IL-4 and IL-10
   was upregulated. Also, 4 significantly increased CD4(+)CD25(+)FoxP3(+)
   Treg cell frequency in the activated splenocytes. Moreover, ConA-induced
   expression of Th1 transcription factors, T-bet and STAT1, as well as of
   Th17-related protein STAT3 was attenuated upon exposure to 4, while the
   expression of Th2-related transcription factor GATA3 remained stable. In
   conclusion, ruthenium(II) complex 4 modulates immune system cell
   functions in vitro by inhibiting T cell differentiation towards
   pathogenic Th1/Th17 phenotype and inducing a regulatory phenotype
   characterized by IL-10 and IL-4 production, which may provide novel
   therapeutic opportunities for immune-inflammatory and/or autoimmune
   disorders.",
journal = "Journal of Biological Inorganic Chemistry",
title = "In vitro effects of binuclear (eta (6)-p-cymene)ruthenium(II) complex
 containing bridging bis(nicotinate)-polyethylene glycol ester ligand on
 differentiation pathways of murine Th lymphocytes activated by T cell
 mitogen",
number = "3",
volume = "20",
doi = "10.1007/s00775-015-1242-x",
pages = "575-583"
}

Momčilović, M., Eichhorn, T., Blaževski, J., Schmidt, H., Kaluđerović, G. N.,& Stošić-Grujičić, S.. (2015). In vitro effects of binuclear (eta (6)-p-cymene)ruthenium(II) complex
 containing bridging bis(nicotinate)-polyethylene glycol ester ligand on
 differentiation pathways of murine Th lymphocytes activated by T cell
 mitogen. in Journal of Biological Inorganic Chemistry, 20(3), 575-583.
https://doi.org/10.1007/s00775-015-1242-x

Momčilović M, Eichhorn T, Blaževski J, Schmidt H, Kaluđerović GN, Stošić-Grujičić S. In vitro effects of binuclear (eta (6)-p-cymene)ruthenium(II) complex
 containing bridging bis(nicotinate)-polyethylene glycol ester ligand on
 differentiation pathways of murine Th lymphocytes activated by T cell
 mitogen. in Journal of Biological Inorganic Chemistry. 2015;20(3):575-583.
doi:10.1007/s00775-015-1242-x .

Momčilović, Miljana, Eichhorn, Thomas, Blaževski, Jana, Schmidt, Harry, Kaluđerović, Goran N., Stošić-Grujičić, Stanislava, "In vitro effects of binuclear (eta (6)-p-cymene)ruthenium(II) complex
 containing bridging bis(nicotinate)-polyethylene glycol ester ligand on
 differentiation pathways of murine Th lymphocytes activated by T cell
 mitogen" in Journal of Biological Inorganic Chemistry, 20, no. 3 (2015):575-583,
https://doi.org/10.1007/s00775-015-1242-x . .

TY  - JOUR
AU  - Kaluđerović, Goran N.
AU  - Krajnović, Tamara
AU  - Momčilović, Miljana
AU  - Stošić-Grujičić, Stanislava
AU  - Mijatović, Sanja
AU  - Maksimović-Ivanić, Danijela
AU  - Hey-Hawkins, Evamarie
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2322
AB  - {[}Ru(eta(6)-p-cym)Cl\{dpa(CH2)(4)COOEt\}]{[}PF6] (cym = cymene; dpa =
   2,2'-dipyridylamine; complex 2) was prepared and characterized by
   elemental analysis, IR and multinuclear NMR spectroscopy, as well as
   ESI-MS and X-ray structural analysis. The structural analog without a
   side chain {[}Ru(eta(6)-p-cym)Cl(dpa)]{[}PF6] (1) as well as 2 were
   investigated in vitro against 518A2, SW480, 8505C, A253 and MCF-7 cell
   lines. Complex 1 is active against all investigated tumor cell lines
   while the activity of compound 2 is limited only to caspase 3 deficient
   MCF-7 breast cancer cells, however, both are less active than cisplatin.
   As CD4(+)Th cells are necessary to trigger all the immune effector
   mechanisms required to eliminate tumor cells, besides testing the in
   vitro antitumor activity of 1 and 2, the effect of ruthenium(II)
   complexes on the cells of the adaptive immune system have also been
   evaluated. Importantly, complex 1 applied in concentrations which were
   effective against tumor cells did not affect immune cell viability, nor
   did exert a general immunosuppressive effect on cytokine production.
   Thus, beneficial characteristics of 1 might contribute to the overall
   therapeutic properties of the complex. (C) 2015 Elsevier Inc. All rights
   reserved.
T2  - Journal of Inorganic Biochemistry
T1  - Ruthenium(II) p-cymene complex bearing 2,2 `-dipyridylamine targets
 caspase 3 deficient MCF-7 breast cancer cells without disruption of
 antitumor immune response
VL  - 153
DO  - 10.1016/j.jinorgbio.2015.09.006
SP  - 315
EP  - 321
ER  - 

@article{
author = "Kaluđerović, Goran N. and Krajnović, Tamara and Momčilović, Miljana and Stošić-Grujičić, Stanislava and Mijatović, Sanja and Maksimović-Ivanić, Danijela and Hey-Hawkins, Evamarie",
year = "2015",
abstract = "{[}Ru(eta(6)-p-cym)Cl\{dpa(CH2)(4)COOEt\}]{[}PF6] (cym = cymene; dpa =
   2,2'-dipyridylamine; complex 2) was prepared and characterized by
   elemental analysis, IR and multinuclear NMR spectroscopy, as well as
   ESI-MS and X-ray structural analysis. The structural analog without a
   side chain {[}Ru(eta(6)-p-cym)Cl(dpa)]{[}PF6] (1) as well as 2 were
   investigated in vitro against 518A2, SW480, 8505C, A253 and MCF-7 cell
   lines. Complex 1 is active against all investigated tumor cell lines
   while the activity of compound 2 is limited only to caspase 3 deficient
   MCF-7 breast cancer cells, however, both are less active than cisplatin.
   As CD4(+)Th cells are necessary to trigger all the immune effector
   mechanisms required to eliminate tumor cells, besides testing the in
   vitro antitumor activity of 1 and 2, the effect of ruthenium(II)
   complexes on the cells of the adaptive immune system have also been
   evaluated. Importantly, complex 1 applied in concentrations which were
   effective against tumor cells did not affect immune cell viability, nor
   did exert a general immunosuppressive effect on cytokine production.
   Thus, beneficial characteristics of 1 might contribute to the overall
   therapeutic properties of the complex. (C) 2015 Elsevier Inc. All rights
   reserved.",
journal = "Journal of Inorganic Biochemistry",
title = "Ruthenium(II) p-cymene complex bearing 2,2 `-dipyridylamine targets
 caspase 3 deficient MCF-7 breast cancer cells without disruption of
 antitumor immune response",
volume = "153",
doi = "10.1016/j.jinorgbio.2015.09.006",
pages = "315-321"
}

Kaluđerović, G. N., Krajnović, T., Momčilović, M., Stošić-Grujičić, S., Mijatović, S., Maksimović-Ivanić, D.,& Hey-Hawkins, E.. (2015). Ruthenium(II) p-cymene complex bearing 2,2 `-dipyridylamine targets
 caspase 3 deficient MCF-7 breast cancer cells without disruption of
 antitumor immune response. in Journal of Inorganic Biochemistry, 153, 315-321.
https://doi.org/10.1016/j.jinorgbio.2015.09.006

Kaluđerović GN, Krajnović T, Momčilović M, Stošić-Grujičić S, Mijatović S, Maksimović-Ivanić D, Hey-Hawkins E. Ruthenium(II) p-cymene complex bearing 2,2 `-dipyridylamine targets
 caspase 3 deficient MCF-7 breast cancer cells without disruption of
 antitumor immune response. in Journal of Inorganic Biochemistry. 2015;153:315-321.
doi:10.1016/j.jinorgbio.2015.09.006 .

Kaluđerović, Goran N., Krajnović, Tamara, Momčilović, Miljana, Stošić-Grujičić, Stanislava, Mijatović, Sanja, Maksimović-Ivanić, Danijela, Hey-Hawkins, Evamarie, "Ruthenium(II) p-cymene complex bearing 2,2 `-dipyridylamine targets
 caspase 3 deficient MCF-7 breast cancer cells without disruption of
 antitumor immune response" in Journal of Inorganic Biochemistry, 153 (2015):315-321,
https://doi.org/10.1016/j.jinorgbio.2015.09.006 . .

TY  - JOUR
AU  - Eichhorn, Thomas
AU  - Hey-Hawkins, Evamarie
AU  - Maksimović-Ivanić, Danijela
AU  - Mojić, Marija
AU  - Schmidt, Juergen
AU  - Mijatović, Sanja
AU  - Schmidt, Harry
AU  - Kaluđerović, Goran N.
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2099
AB  - Neutral binuclear ruthenium complexes 1, 2, 3, 4, 5, 6, 7, 8 of the
   general formula {[}\{RuCl2((6)-p-cym)\}(2)-(NN)] (NN=bis(nicotinate)-
   and bis(isonicotinate)-polyethylene glycol esters:
   (3-py)COO(CH2CH2O)(n)CO(3-py) and (4-py)COO(CH2CH2O)(n)CO(4-py), n
   =1-4), as well as mononuclear
   {[}RuCl2((6)-p-cym)((3-py)COO(CH2CH2OCH3)-N)], complex 9, were
   synthesized and characterized using elemental analysis and electrospray
   ionization high-resolution mass spectrometry, infrared, H-1 NMR and C-13
   NMR spectroscopies. Stability of the binuclear complexes in the presence
   of dimethylsulfoxide was studied. Furthermore, formation of a cationic
   complex containing bridging pyridine-based bidentate ligand was
   monitored using H-1 NMR spectroscopy. Ligand precursors, polyethylene
   glycol esters of nicotinic (L12HCl-L42HCl and L9HCl) and isonicotinic
   acid dihydrochlorides (L52HCl-L82HCl), binuclear ruthenium(II) complexes
   1, 2, 3, 4, 5, 6, 7, 8 and mononuclear complex 9 were tested for in
   vitro cytotoxicity against 518A2 (melanoma), 8505C (anaplastic thyroid
   cancer), A253 (head and neck tumour), MCF-7 (breast tumour) and SW480
   (colon carcinoma) cell lines. Copyright (c) 2014 John Wiley \& Sons,
   Ltd.
T2  - Applied Organometallic Chemistry
T1  - Binuclear dichlorido(eta(6)-p-cymene)ruthenium(II) complexes with
 bis(nicotinate)- and bis (isonicotinate)-polyethylene glycol ester
 ligands
IS  - 1
VL  - 29
DO  - 10.1002/aoc.3238
SP  - 20
EP  - 25
ER  - 

@article{
author = "Eichhorn, Thomas and Hey-Hawkins, Evamarie and Maksimović-Ivanić, Danijela and Mojić, Marija and Schmidt, Juergen and Mijatović, Sanja and Schmidt, Harry and Kaluđerović, Goran N.",
year = "2015",
abstract = "Neutral binuclear ruthenium complexes 1, 2, 3, 4, 5, 6, 7, 8 of the
   general formula {[}\{RuCl2((6)-p-cym)\}(2)-(NN)] (NN=bis(nicotinate)-
   and bis(isonicotinate)-polyethylene glycol esters:
   (3-py)COO(CH2CH2O)(n)CO(3-py) and (4-py)COO(CH2CH2O)(n)CO(4-py), n
   =1-4), as well as mononuclear
   {[}RuCl2((6)-p-cym)((3-py)COO(CH2CH2OCH3)-N)], complex 9, were
   synthesized and characterized using elemental analysis and electrospray
   ionization high-resolution mass spectrometry, infrared, H-1 NMR and C-13
   NMR spectroscopies. Stability of the binuclear complexes in the presence
   of dimethylsulfoxide was studied. Furthermore, formation of a cationic
   complex containing bridging pyridine-based bidentate ligand was
   monitored using H-1 NMR spectroscopy. Ligand precursors, polyethylene
   glycol esters of nicotinic (L12HCl-L42HCl and L9HCl) and isonicotinic
   acid dihydrochlorides (L52HCl-L82HCl), binuclear ruthenium(II) complexes
   1, 2, 3, 4, 5, 6, 7, 8 and mononuclear complex 9 were tested for in
   vitro cytotoxicity against 518A2 (melanoma), 8505C (anaplastic thyroid
   cancer), A253 (head and neck tumour), MCF-7 (breast tumour) and SW480
   (colon carcinoma) cell lines. Copyright (c) 2014 John Wiley \& Sons,
   Ltd.",
journal = "Applied Organometallic Chemistry",
title = "Binuclear dichlorido(eta(6)-p-cymene)ruthenium(II) complexes with
 bis(nicotinate)- and bis (isonicotinate)-polyethylene glycol ester
 ligands",
number = "1",
volume = "29",
doi = "10.1002/aoc.3238",
pages = "20-25"
}

Eichhorn, T., Hey-Hawkins, E., Maksimović-Ivanić, D., Mojić, M., Schmidt, J., Mijatović, S., Schmidt, H.,& Kaluđerović, G. N.. (2015). Binuclear dichlorido(eta(6)-p-cymene)ruthenium(II) complexes with
 bis(nicotinate)- and bis (isonicotinate)-polyethylene glycol ester
 ligands. in Applied Organometallic Chemistry, 29(1), 20-25.
https://doi.org/10.1002/aoc.3238

Eichhorn T, Hey-Hawkins E, Maksimović-Ivanić D, Mojić M, Schmidt J, Mijatović S, Schmidt H, Kaluđerović GN. Binuclear dichlorido(eta(6)-p-cymene)ruthenium(II) complexes with
 bis(nicotinate)- and bis (isonicotinate)-polyethylene glycol ester
 ligands. in Applied Organometallic Chemistry. 2015;29(1):20-25.
doi:10.1002/aoc.3238 .

Eichhorn, Thomas, Hey-Hawkins, Evamarie, Maksimović-Ivanić, Danijela, Mojić, Marija, Schmidt, Juergen, Mijatović, Sanja, Schmidt, Harry, Kaluđerović, Goran N., "Binuclear dichlorido(eta(6)-p-cymene)ruthenium(II) complexes with
 bis(nicotinate)- and bis (isonicotinate)-polyethylene glycol ester
 ligands" in Applied Organometallic Chemistry, 29, no. 1 (2015):20-25,
https://doi.org/10.1002/aoc.3238 . .

TY  - JOUR
AU  - Bulatović, Mirna Z.
AU  - Kaluderovic, Milena R.
AU  - Mojić, Marija
AU  - Zmejkovski, Bojana B.
AU  - Hey-Hawkins, Evamarie
AU  - Vidaković, Melita
AU  - Grdović, Nevena
AU  - Kaluđerović, Goran N.
AU  - Mijatović, Sanja
AU  - Maksimović-Ivanić, Danijela
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1916
AB  - (O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplati
   num(IV), {[}PtCl4(iBu(2)eddp)]. shows an improved pharmacological
   profile in comparison to cisplatin. This is manifested through
   accelerated dying process led by necrotic cell death, reflected through
   mitochondrial collapse, strong ATP depletion and reactive oxygen species
   production. Loss of mitochondrial potential was further followed with
   intensive apoptosis that finalized with DNA fragmentation.
   Different dynamic of tumoricidal action could be partly ascribed to less
   affected repair mechanisms in comparison to cisplatin. Importantly,
   {[}PtCl4(iBu(2)eddp)] did not induce necrosis in primary fibroblasts
   suggesting different intracellular response of normal vs. tumor cells.
   This selectivity toward malignant phenotype is further confirmed by
   retained tumoricidal potential in hypoxic conditions, while cisplatin
   became completely inefficient. (C) 2015 Published by Elsevier B.V.
T2  - European Journal of Pharmacology
T1  - Improved in vitro antitumor potential of
 (O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplati
 num(IV) complex under normoxic and hypoxic conditions
VL  - 760
DO  - 10.1016/j.ejphar.2015.04.012
SP  - 136
EP  - 144
ER  - 

@article{
author = "Bulatović, Mirna Z. and Kaluderovic, Milena R. and Mojić, Marija and Zmejkovski, Bojana B. and Hey-Hawkins, Evamarie and Vidaković, Melita and Grdović, Nevena and Kaluđerović, Goran N. and Mijatović, Sanja and Maksimović-Ivanić, Danijela",
year = "2015",
abstract = "(O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplati
   num(IV), {[}PtCl4(iBu(2)eddp)]. shows an improved pharmacological
   profile in comparison to cisplatin. This is manifested through
   accelerated dying process led by necrotic cell death, reflected through
   mitochondrial collapse, strong ATP depletion and reactive oxygen species
   production. Loss of mitochondrial potential was further followed with
   intensive apoptosis that finalized with DNA fragmentation.
   Different dynamic of tumoricidal action could be partly ascribed to less
   affected repair mechanisms in comparison to cisplatin. Importantly,
   {[}PtCl4(iBu(2)eddp)] did not induce necrosis in primary fibroblasts
   suggesting different intracellular response of normal vs. tumor cells.
   This selectivity toward malignant phenotype is further confirmed by
   retained tumoricidal potential in hypoxic conditions, while cisplatin
   became completely inefficient. (C) 2015 Published by Elsevier B.V.",
journal = "European Journal of Pharmacology",
title = "Improved in vitro antitumor potential of
 (O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplati
 num(IV) complex under normoxic and hypoxic conditions",
volume = "760",
doi = "10.1016/j.ejphar.2015.04.012",
pages = "136-144"
}

Bulatović, M. Z., Kaluderovic, M. R., Mojić, M., Zmejkovski, B. B., Hey-Hawkins, E., Vidaković, M., Grdović, N., Kaluđerović, G. N., Mijatović, S.,& Maksimović-Ivanić, D.. (2015). Improved in vitro antitumor potential of
 (O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplati
 num(IV) complex under normoxic and hypoxic conditions. in European Journal of Pharmacology, 760, 136-144.
https://doi.org/10.1016/j.ejphar.2015.04.012

Bulatović MZ, Kaluderovic MR, Mojić M, Zmejkovski BB, Hey-Hawkins E, Vidaković M, Grdović N, Kaluđerović GN, Mijatović S, Maksimović-Ivanić D. Improved in vitro antitumor potential of
 (O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplati
 num(IV) complex under normoxic and hypoxic conditions. in European Journal of Pharmacology. 2015;760:136-144.
doi:10.1016/j.ejphar.2015.04.012 .

Bulatović, Mirna Z., Kaluderovic, Milena R., Mojić, Marija, Zmejkovski, Bojana B., Hey-Hawkins, Evamarie, Vidaković, Melita, Grdović, Nevena, Kaluđerović, Goran N., Mijatović, Sanja, Maksimović-Ivanić, Danijela, "Improved in vitro antitumor potential of
 (O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplati
 num(IV) complex under normoxic and hypoxic conditions" in European Journal of Pharmacology, 760 (2015):136-144,
https://doi.org/10.1016/j.ejphar.2015.04.012 . .

TY  - JOUR
AU  - Mijatović, Sanja
AU  - Bulatović, Mirna Z.
AU  - Mojić, Marija
AU  - Stošić-Grujičić, Stanislava
AU  - Miljković, Đorđe
AU  - Maksimović-Ivanić, Danijela
AU  - Gomez-Ruiz, Santiago
AU  - Pinkas, Jiri
AU  - Horacek, Michal
AU  - Kaluđerović, Goran N.
PY  - 2014
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2247
AB  - The previously known complexes {[}Ti\{(Me2CMe2C)(eta(5)-C5H4)(2)\}Cl-2]
   (1), {[}Ti\{Me2C(eta(5)-C5H4)(2)\}Cl-2] (2), {[}Ti
   \{Me2Si(eta(5)-C5H4)(2)\}Cl-2] (4), {[}Ti\{MePhSi(eta(5)-C5H4)(2)\}Cl-2]
   (5) and {[}Ti\{MePhSi(eta(5)-C5Me4)(2)\}Cl-2] (6) have been prepared
   following reported procedures. The novel complex
   {[}Ti\{MePhC(eta(5)-C5H4)(2)\}Cl-2] (3) has been prepared and
   characterized. The cytotoxic activity of 1-6 has been tested after 72 h
   on melanoma A375 and B16, prostate cancer DU145 and LNCaP and colon
   cancer HCT116, SW620 and CT26CL25 cell lines observing a high cytotoxic
   activity of complexes 1 and 6 compared to the reference compound
   ({[}Ti(eta(5)-C5H5)(2)\}Cl-2]). 1 and 6 have also been tested against
   primary normal mouse keratinocytes and lung fibroblasts. While viability
   of both type of primary cells was significantly less affected by 1 in
   comparison to the reference compound {[}Ti(eta(5)-C5H5)(2)Cl-2],
   compound 6 was completely nontoxic for nonmalignant cells, indicating a
   potential selectivity of this compound towards cancer cell lines. In
   addition CFSE staining, cell cycle analysis, AnnexinV-FITC/PI staining,
   detection of caspase activity and mitochondrial potential showed that 1
   and 6 were acting through inhibition of proliferation and subsequent
   induction of mitochondrial dependent apoptosis in colon cancer cell
   lines, HCT116 and SW620, which express low sensitivity to cisplatin.
   Compound 6 was found to be the leading drug in this group since it shows
   the fastest and most selective anticancer profile. (C) 2013 Elsevier
   B.V. All rights reserved.
T2  - Journal of Organometallic Chemistry
T1  - Study of the anticancer properties of methyl- and phenyl-substituted
 carbon- and silicon-bridged ansa-titanocene complexes
VL  - 751
DO  - 10.1016/j.jorganchem.2013.07.059
SP  - 361
EP  - 367
ER  - 

@article{
author = "Mijatović, Sanja and Bulatović, Mirna Z. and Mojić, Marija and Stošić-Grujičić, Stanislava and Miljković, Đorđe and Maksimović-Ivanić, Danijela and Gomez-Ruiz, Santiago and Pinkas, Jiri and Horacek, Michal and Kaluđerović, Goran N.",
year = "2014",
abstract = "The previously known complexes {[}Ti\{(Me2CMe2C)(eta(5)-C5H4)(2)\}Cl-2]
   (1), {[}Ti\{Me2C(eta(5)-C5H4)(2)\}Cl-2] (2), {[}Ti
   \{Me2Si(eta(5)-C5H4)(2)\}Cl-2] (4), {[}Ti\{MePhSi(eta(5)-C5H4)(2)\}Cl-2]
   (5) and {[}Ti\{MePhSi(eta(5)-C5Me4)(2)\}Cl-2] (6) have been prepared
   following reported procedures. The novel complex
   {[}Ti\{MePhC(eta(5)-C5H4)(2)\}Cl-2] (3) has been prepared and
   characterized. The cytotoxic activity of 1-6 has been tested after 72 h
   on melanoma A375 and B16, prostate cancer DU145 and LNCaP and colon
   cancer HCT116, SW620 and CT26CL25 cell lines observing a high cytotoxic
   activity of complexes 1 and 6 compared to the reference compound
   ({[}Ti(eta(5)-C5H5)(2)\}Cl-2]). 1 and 6 have also been tested against
   primary normal mouse keratinocytes and lung fibroblasts. While viability
   of both type of primary cells was significantly less affected by 1 in
   comparison to the reference compound {[}Ti(eta(5)-C5H5)(2)Cl-2],
   compound 6 was completely nontoxic for nonmalignant cells, indicating a
   potential selectivity of this compound towards cancer cell lines. In
   addition CFSE staining, cell cycle analysis, AnnexinV-FITC/PI staining,
   detection of caspase activity and mitochondrial potential showed that 1
   and 6 were acting through inhibition of proliferation and subsequent
   induction of mitochondrial dependent apoptosis in colon cancer cell
   lines, HCT116 and SW620, which express low sensitivity to cisplatin.
   Compound 6 was found to be the leading drug in this group since it shows
   the fastest and most selective anticancer profile. (C) 2013 Elsevier
   B.V. All rights reserved.",
journal = "Journal of Organometallic Chemistry",
title = "Study of the anticancer properties of methyl- and phenyl-substituted
 carbon- and silicon-bridged ansa-titanocene complexes",
volume = "751",
doi = "10.1016/j.jorganchem.2013.07.059",
pages = "361-367"
}

Mijatović, S., Bulatović, M. Z., Mojić, M., Stošić-Grujičić, S., Miljković, Đ., Maksimović-Ivanić, D., Gomez-Ruiz, S., Pinkas, J., Horacek, M.,& Kaluđerović, G. N.. (2014). Study of the anticancer properties of methyl- and phenyl-substituted
 carbon- and silicon-bridged ansa-titanocene complexes. in Journal of Organometallic Chemistry, 751, 361-367.
https://doi.org/10.1016/j.jorganchem.2013.07.059

Mijatović S, Bulatović MZ, Mojić M, Stošić-Grujičić S, Miljković Đ, Maksimović-Ivanić D, Gomez-Ruiz S, Pinkas J, Horacek M, Kaluđerović GN. Study of the anticancer properties of methyl- and phenyl-substituted
 carbon- and silicon-bridged ansa-titanocene complexes. in Journal of Organometallic Chemistry. 2014;751:361-367.
doi:10.1016/j.jorganchem.2013.07.059 .

Mijatović, Sanja, Bulatović, Mirna Z., Mojić, Marija, Stošić-Grujičić, Stanislava, Miljković, Đorđe, Maksimović-Ivanić, Danijela, Gomez-Ruiz, Santiago, Pinkas, Jiri, Horacek, Michal, Kaluđerović, Goran N., "Study of the anticancer properties of methyl- and phenyl-substituted
 carbon- and silicon-bridged ansa-titanocene complexes" in Journal of Organometallic Chemistry, 751 (2014):361-367,
https://doi.org/10.1016/j.jorganchem.2013.07.059 . .

TY  - JOUR
AU  - Bulatović, Mirna Z.
AU  - Maksimović-Ivanić, Danijela
AU  - Bensing, Christian
AU  - Gomez-Ruiz, Santiago
AU  - Steinborn, Dirk
AU  - Schmidt, Harry
AU  - Mojić, Marija
AU  - Korac, Aleksandra
AU  - Golic, Igor
AU  - Perez-Quintanilla, Damian
AU  - Momčilović, Miljana
AU  - Mijatović, Sanja
AU  - Kaluđerović, Goran N.
PY  - 2014
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2205
AB  - The strong therapeutic potential of an organotin(IV) compound loaded in
   nanostructured silica (SBA-15pSn) is demonstrated: B16 melanoma tumor
   growth in syngeneic C57BL/6 mice is almost completely abolished. In
   contrast to apoptosis as the basic mechanism of the anticancer action of
   numerous chemotherapeutics, the important advantage of this SBA-15pSn
   mesoporous material is the induction of cell differentiation, an effect
   unknown for metal-based drugs and nanomaterials alone. This
   non-aggressive mode of drug action is highly efficient against cancer
   cells but is in the concentration range used nontoxic for normal tissue.
   JNK (Jun-amino-terminal kinase)-independent apoptosis accompanied by the
   development of the melanocyte-like nonproliferative phenotype of
   survived cells indicates the extraordinary potential of SBA-15pSn to
   suppress tumor growth without undesirable compensatory proliferation of
   malignant cells in response to neighboring cell death.
T2  - Angewandte Chemie-International Edition
T1  - Organotin(IV)-Loaded Mesoporous Silica as a Biocompatible Strategy in
 Cancer Treatment
IS  - 23
VL  - 53
DO  - 10.1002/anie.201400763
SP  - 5982
EP  - 5987
ER  - 

@article{
author = "Bulatović, Mirna Z. and Maksimović-Ivanić, Danijela and Bensing, Christian and Gomez-Ruiz, Santiago and Steinborn, Dirk and Schmidt, Harry and Mojić, Marija and Korac, Aleksandra and Golic, Igor and Perez-Quintanilla, Damian and Momčilović, Miljana and Mijatović, Sanja and Kaluđerović, Goran N.",
year = "2014",
abstract = "The strong therapeutic potential of an organotin(IV) compound loaded in
   nanostructured silica (SBA-15pSn) is demonstrated: B16 melanoma tumor
   growth in syngeneic C57BL/6 mice is almost completely abolished. In
   contrast to apoptosis as the basic mechanism of the anticancer action of
   numerous chemotherapeutics, the important advantage of this SBA-15pSn
   mesoporous material is the induction of cell differentiation, an effect
   unknown for metal-based drugs and nanomaterials alone. This
   non-aggressive mode of drug action is highly efficient against cancer
   cells but is in the concentration range used nontoxic for normal tissue.
   JNK (Jun-amino-terminal kinase)-independent apoptosis accompanied by the
   development of the melanocyte-like nonproliferative phenotype of
   survived cells indicates the extraordinary potential of SBA-15pSn to
   suppress tumor growth without undesirable compensatory proliferation of
   malignant cells in response to neighboring cell death.",
journal = "Angewandte Chemie-International Edition",
title = "Organotin(IV)-Loaded Mesoporous Silica as a Biocompatible Strategy in
 Cancer Treatment",
number = "23",
volume = "53",
doi = "10.1002/anie.201400763",
pages = "5982-5987"
}

Bulatović, M. Z., Maksimović-Ivanić, D., Bensing, C., Gomez-Ruiz, S., Steinborn, D., Schmidt, H., Mojić, M., Korac, A., Golic, I., Perez-Quintanilla, D., Momčilović, M., Mijatović, S.,& Kaluđerović, G. N.. (2014). Organotin(IV)-Loaded Mesoporous Silica as a Biocompatible Strategy in
 Cancer Treatment. in Angewandte Chemie-International Edition, 53(23), 5982-5987.
https://doi.org/10.1002/anie.201400763

Bulatović MZ, Maksimović-Ivanić D, Bensing C, Gomez-Ruiz S, Steinborn D, Schmidt H, Mojić M, Korac A, Golic I, Perez-Quintanilla D, Momčilović M, Mijatović S, Kaluđerović GN. Organotin(IV)-Loaded Mesoporous Silica as a Biocompatible Strategy in
 Cancer Treatment. in Angewandte Chemie-International Edition. 2014;53(23):5982-5987.
doi:10.1002/anie.201400763 .

Bulatović, Mirna Z., Maksimović-Ivanić, Danijela, Bensing, Christian, Gomez-Ruiz, Santiago, Steinborn, Dirk, Schmidt, Harry, Mojić, Marija, Korac, Aleksandra, Golic, Igor, Perez-Quintanilla, Damian, Momčilović, Miljana, Mijatović, Sanja, Kaluđerović, Goran N., "Organotin(IV)-Loaded Mesoporous Silica as a Biocompatible Strategy in
 Cancer Treatment" in Angewandte Chemie-International Edition, 53, no. 23 (2014):5982-5987,
https://doi.org/10.1002/anie.201400763 . .

TY  - JOUR
AU  - Ludwig, Gerd
AU  - Randelovic, Ivan
AU  - Maksimović-Ivanić, Danijela
AU  - Mijatović, Sanja
AU  - Bulatović, Mirna Z.
AU  - Miljković, Đorđe
AU  - Korb, Marcus
AU  - Lang, Heinrich
AU  - Steinborn, Dirk
AU  - Kaluđerović, Goran N.
PY  - 2014
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2193
AB  - Iridium(III) complexes of the type
   {[}Ir(eta(5)-C5Me5)Cl-2\{Ph2PCH2-CH2CH2S(O)(x)Ph-kappa P\}] (x=0-2; 1-3)
   and {[}Ir(eta(5)-C5Me5)Cl\{Ph2PCH2-CH2CH2S(O)(x)Ph-kappa P,kappa
   S\}]{[}PF6] (x=0-1; 4 and 5) with 3-(diphenyl-phosphino)propyl phenyl
   sulfide, sulfoxide, and sulfone ligands Ph2PCH2CH2CH2S(O)(x)Ph were
   designed, synthesized, and characterized fully, including X-ray
   diffraction analyses for complexes 3 and 4. In vitro studies against
   human thyroid carcinoma (8505C), submandibular carcinoma (A253), breast
   adenocarcinoma (MCF-7), colon adenocarcinoma (SW480), and melano-ma
   (518A2) cell lines provided evidence for the high biological potential
   of the neutral and cationic iridium(III) complexes. Neutral iridium(III)
   complex 5 proved to be the most active, with IC50 values up to about 0.1
   mu m, representing activities of up to one order of magnitude higher
   than cisplatin. Using 8505C cells, apoptosis was shown to be the main
   mechanism through which complex 5 exerts its tumoricidal action. The
   described iridium(III) complexes represent potential leads in the search
   for novel metal-based anticancer agents.
T2  - Chemmedchem
T1  - Anticancer Potential of
 (Pentamethylcyclopentadienyl)chloridoiridium(III) Complexes Bearing
 kappa P and kappa P,kappa S-Coordinated Ph2PCH2CH2CH2S(O)(x)Ph (x=0-2)
 Ligands
IS  - 7
VL  - 9
DO  - 10.1002/cmdc.201300479
SP  - 1586
EP  - 1593
ER  - 

@article{
author = "Ludwig, Gerd and Randelovic, Ivan and Maksimović-Ivanić, Danijela and Mijatović, Sanja and Bulatović, Mirna Z. and Miljković, Đorđe and Korb, Marcus and Lang, Heinrich and Steinborn, Dirk and Kaluđerović, Goran N.",
year = "2014",
abstract = "Iridium(III) complexes of the type
   {[}Ir(eta(5)-C5Me5)Cl-2\{Ph2PCH2-CH2CH2S(O)(x)Ph-kappa P\}] (x=0-2; 1-3)
   and {[}Ir(eta(5)-C5Me5)Cl\{Ph2PCH2-CH2CH2S(O)(x)Ph-kappa P,kappa
   S\}]{[}PF6] (x=0-1; 4 and 5) with 3-(diphenyl-phosphino)propyl phenyl
   sulfide, sulfoxide, and sulfone ligands Ph2PCH2CH2CH2S(O)(x)Ph were
   designed, synthesized, and characterized fully, including X-ray
   diffraction analyses for complexes 3 and 4. In vitro studies against
   human thyroid carcinoma (8505C), submandibular carcinoma (A253), breast
   adenocarcinoma (MCF-7), colon adenocarcinoma (SW480), and melano-ma
   (518A2) cell lines provided evidence for the high biological potential
   of the neutral and cationic iridium(III) complexes. Neutral iridium(III)
   complex 5 proved to be the most active, with IC50 values up to about 0.1
   mu m, representing activities of up to one order of magnitude higher
   than cisplatin. Using 8505C cells, apoptosis was shown to be the main
   mechanism through which complex 5 exerts its tumoricidal action. The
   described iridium(III) complexes represent potential leads in the search
   for novel metal-based anticancer agents.",
journal = "Chemmedchem",
title = "Anticancer Potential of
 (Pentamethylcyclopentadienyl)chloridoiridium(III) Complexes Bearing
 kappa P and kappa P,kappa S-Coordinated Ph2PCH2CH2CH2S(O)(x)Ph (x=0-2)
 Ligands",
number = "7",
volume = "9",
doi = "10.1002/cmdc.201300479",
pages = "1586-1593"
}

Ludwig, G., Randelovic, I., Maksimović-Ivanić, D., Mijatović, S., Bulatović, M. Z., Miljković, Đ., Korb, M., Lang, H., Steinborn, D.,& Kaluđerović, G. N.. (2014). Anticancer Potential of
 (Pentamethylcyclopentadienyl)chloridoiridium(III) Complexes Bearing
 kappa P and kappa P,kappa S-Coordinated Ph2PCH2CH2CH2S(O)(x)Ph (x=0-2)
 Ligands. in Chemmedchem, 9(7), 1586-1593.
https://doi.org/10.1002/cmdc.201300479

Ludwig G, Randelovic I, Maksimović-Ivanić D, Mijatović S, Bulatović MZ, Miljković Đ, Korb M, Lang H, Steinborn D, Kaluđerović GN. Anticancer Potential of
 (Pentamethylcyclopentadienyl)chloridoiridium(III) Complexes Bearing
 kappa P and kappa P,kappa S-Coordinated Ph2PCH2CH2CH2S(O)(x)Ph (x=0-2)
 Ligands. in Chemmedchem. 2014;9(7):1586-1593.
doi:10.1002/cmdc.201300479 .

Ludwig, Gerd, Randelovic, Ivan, Maksimović-Ivanić, Danijela, Mijatović, Sanja, Bulatović, Mirna Z., Miljković, Đorđe, Korb, Marcus, Lang, Heinrich, Steinborn, Dirk, Kaluđerović, Goran N., "Anticancer Potential of
 (Pentamethylcyclopentadienyl)chloridoiridium(III) Complexes Bearing
 kappa P and kappa P,kappa S-Coordinated Ph2PCH2CH2CH2S(O)(x)Ph (x=0-2)
 Ligands" in Chemmedchem, 9, no. 7 (2014):1586-1593,
https://doi.org/10.1002/cmdc.201300479 . .

TY  - JOUR
AU  - Ceballos-Torres, Jesus
AU  - del Hierro, Isabel
AU  - Prashar, Sanjiv
AU  - Fajardo, Mariano
AU  - Mijatović, Sanja
AU  - Maksimović-Ivanić, Danijela
AU  - Kaluđerović, Goran N.
AU  - Gomez-Ruiz, Santiago
PY  - 2014
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2139
AB  - Four alkenyl-substituted titanocene dichloride complexes
   {[}Ti(eta(5)-C5H5)\{eta(5)-C5H4(CMeR(CH2CH2CH=CH2))\}Cl-2] (R = Me (8),
   Ph (9)) and
   {[}Ti(eta(5)-C5H5)\{eta(5)-C5H3(CMeR(CH2CH2CH=CH2))(SiMe3)\}] (R = Me
   (10), Ph (11)) have been synthesized and characterized.
   The cytotoxic activity of 8-11 has been tested against human tumour cell
   lines from four different tissue origins {[}8505C (anaplastic thyroid
   cancer), DLD-1 (colon cancer), FaDu (head and neck cancer), A2780
   (ovarian cancer) and A549 (lung carcinoma)] and compared with those of
   the reference complexes {[}Ti(eta(5)-C5H5)(2)Cl-2] and cisplatin. The
   majority of the studied titanocene compounds are more active than the
   reference complex {[}Ti(eta(5)-C5H5)(2)Cl-2] indicating that the
   presence of alkenyl substituents leads to an increase in the cytotoxic
   activity. In addition, the presence of a trimethylsilyl group on the
   cyclopentadienyl ring also leads to an increase in the cytotoxic
   activity of 10 with respect to 8. The contrary is observed for 9 and 11
   (except on the DLD-1 cell line) with 9 (without -SiMe3) being more
   active than 11 (with -SiMe3). However, all synthesized complexes,
   exhibited lower cytotoxic activity than cisplatin.
   Stability and binding studies based on cyclic voltammetry and UV-visible
   spectroscopy have been carried out in order to explore possible
   interactions between titanocene derivatives and various intracellular
   molecules, such as the nitrogenous bases cytosine and thymine, the
   nucleotides adenosine and guanosine, and single-strand fish sperm DNA
   (FS-DNA). These experiments have allowed us to construct models to
   examine the interactions and action mechanisms of titanocene complexes
   inside the cells. In addition, this is one of the first studies on the
   interactions of titanocene derivatives with DNA fragments using cyclic
   voltammetry. (c) 2014 Elsevier B.V. All rights reserved.
T2  - Journal of Organometallic Chemistry
T1  - Alkenyl-substituted titanocene dichloride complexes: Stability studies,
 binding and cytotoxicity
VL  - 769
DO  - 10.1016/j.jorganchem.2014.06.031
SP  - 46
EP  - 57
ER  - 

@article{
author = "Ceballos-Torres, Jesus and del Hierro, Isabel and Prashar, Sanjiv and Fajardo, Mariano and Mijatović, Sanja and Maksimović-Ivanić, Danijela and Kaluđerović, Goran N. and Gomez-Ruiz, Santiago",
year = "2014",
abstract = "Four alkenyl-substituted titanocene dichloride complexes
   {[}Ti(eta(5)-C5H5)\{eta(5)-C5H4(CMeR(CH2CH2CH=CH2))\}Cl-2] (R = Me (8),
   Ph (9)) and
   {[}Ti(eta(5)-C5H5)\{eta(5)-C5H3(CMeR(CH2CH2CH=CH2))(SiMe3)\}] (R = Me
   (10), Ph (11)) have been synthesized and characterized.
   The cytotoxic activity of 8-11 has been tested against human tumour cell
   lines from four different tissue origins {[}8505C (anaplastic thyroid
   cancer), DLD-1 (colon cancer), FaDu (head and neck cancer), A2780
   (ovarian cancer) and A549 (lung carcinoma)] and compared with those of
   the reference complexes {[}Ti(eta(5)-C5H5)(2)Cl-2] and cisplatin. The
   majority of the studied titanocene compounds are more active than the
   reference complex {[}Ti(eta(5)-C5H5)(2)Cl-2] indicating that the
   presence of alkenyl substituents leads to an increase in the cytotoxic
   activity. In addition, the presence of a trimethylsilyl group on the
   cyclopentadienyl ring also leads to an increase in the cytotoxic
   activity of 10 with respect to 8. The contrary is observed for 9 and 11
   (except on the DLD-1 cell line) with 9 (without -SiMe3) being more
   active than 11 (with -SiMe3). However, all synthesized complexes,
   exhibited lower cytotoxic activity than cisplatin.
   Stability and binding studies based on cyclic voltammetry and UV-visible
   spectroscopy have been carried out in order to explore possible
   interactions between titanocene derivatives and various intracellular
   molecules, such as the nitrogenous bases cytosine and thymine, the
   nucleotides adenosine and guanosine, and single-strand fish sperm DNA
   (FS-DNA). These experiments have allowed us to construct models to
   examine the interactions and action mechanisms of titanocene complexes
   inside the cells. In addition, this is one of the first studies on the
   interactions of titanocene derivatives with DNA fragments using cyclic
   voltammetry. (c) 2014 Elsevier B.V. All rights reserved.",
journal = "Journal of Organometallic Chemistry",
title = "Alkenyl-substituted titanocene dichloride complexes: Stability studies,
 binding and cytotoxicity",
volume = "769",
doi = "10.1016/j.jorganchem.2014.06.031",
pages = "46-57"
}

Ceballos-Torres, J., del Hierro, I., Prashar, S., Fajardo, M., Mijatović, S., Maksimović-Ivanić, D., Kaluđerović, G. N.,& Gomez-Ruiz, S.. (2014). Alkenyl-substituted titanocene dichloride complexes: Stability studies,
 binding and cytotoxicity. in Journal of Organometallic Chemistry, 769, 46-57.
https://doi.org/10.1016/j.jorganchem.2014.06.031

Ceballos-Torres J, del Hierro I, Prashar S, Fajardo M, Mijatović S, Maksimović-Ivanić D, Kaluđerović GN, Gomez-Ruiz S. Alkenyl-substituted titanocene dichloride complexes: Stability studies,
 binding and cytotoxicity. in Journal of Organometallic Chemistry. 2014;769:46-57.
doi:10.1016/j.jorganchem.2014.06.031 .

Ceballos-Torres, Jesus, del Hierro, Isabel, Prashar, Sanjiv, Fajardo, Mariano, Mijatović, Sanja, Maksimović-Ivanić, Danijela, Kaluđerović, Goran N., Gomez-Ruiz, Santiago, "Alkenyl-substituted titanocene dichloride complexes: Stability studies,
 binding and cytotoxicity" in Journal of Organometallic Chemistry, 769 (2014):46-57,
https://doi.org/10.1016/j.jorganchem.2014.06.031 . .

TY  - JOUR
AU  - Blaževski, Jana
AU  - Petković, Filip
AU  - Momčilović, Miljana
AU  - Paschke, Reinhard
AU  - Kaluđerović, Goran N.
AU  - Mostarica-Stojković, Marija B
AU  - Miljković, Đorđe
PY  - 2013
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1037
AB  - Aim: To investigate the influences of betulinic acid (BA), a triterpenoid isolated from birch bark, on neuroinflammatory mediators involved in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis in vitro. Methods: Encephalitogenic T cells were prepared from draining lymph nodes and spinal cords of Dark Agouti rats 8 to 10 d after immunization with myelin basic protein (MBP) and complete Freund's adjuvant. Macrophages were isolated from the peritoneal cavity of adult untreated rats. Astrocytes were isolated from neonatal rat brains. The cells were cultured and then treated with different agents. IFN-gamma, IL-17, iNOS and CXCL12 mRNA levels in the cells were analyzed with RT-PCR. iNOS and CXCL12 protein levels were detected using immunoblot. NO and ROS generation was measured using Griess reaction and flow cytometry, respectively. Results: In encephalitogenic T cells stimulated with MBP (10 mu g/mL), addition of BA inhibited IL-17 and IFN-gamma production in a dose-dependent manner. The estimated IC50 values for IL-17 and IFN gamma were 11.2 and 63.8 mu mol/L, respectively. When the macrophages were stimulated with LPS (10 ng/mL), addition of BA (50 mu mol/L) significantly increased ROS generation, and suppressed NO generation. The astrocytes were stimulated with ConASn containing numerous inflammatory mediators, which mimicked the inflammatory milieu within CNS; addition of BA (50 mu mol/L) significantly increased ROS generation, and blocked ConASn-induced increases in iNOS and CXCL12 mRNA levels, but did not affect iNOS and CXCL12 protein levels. Importantly, in both the macrophages and astrocytes, addition of BA (50 mu mol/L) inhibited lipid peroxidation. Conclusion: Besides inhibiting encephalitogenic T cell cytokines and reducing NO generation, BA induces tissue-damaging ROS generation within CNS.
T2  - Acta Pharmacologica Sinica
T1  - Betulinic acid regulates generation of neuroinflammatory mediators responsible for tissue destruction in multiple sclerosis in vitro
IS  - 3
VL  - 34
SP  - 51
EP  - 431
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1037
ER  - 

@article{
author = "Blaževski, Jana and Petković, Filip and Momčilović, Miljana and Paschke, Reinhard and Kaluđerović, Goran N. and Mostarica-Stojković, Marija B and Miljković, Đorđe",
year = "2013",
abstract = "Aim: To investigate the influences of betulinic acid (BA), a triterpenoid isolated from birch bark, on neuroinflammatory mediators involved in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis in vitro. Methods: Encephalitogenic T cells were prepared from draining lymph nodes and spinal cords of Dark Agouti rats 8 to 10 d after immunization with myelin basic protein (MBP) and complete Freund's adjuvant. Macrophages were isolated from the peritoneal cavity of adult untreated rats. Astrocytes were isolated from neonatal rat brains. The cells were cultured and then treated with different agents. IFN-gamma, IL-17, iNOS and CXCL12 mRNA levels in the cells were analyzed with RT-PCR. iNOS and CXCL12 protein levels were detected using immunoblot. NO and ROS generation was measured using Griess reaction and flow cytometry, respectively. Results: In encephalitogenic T cells stimulated with MBP (10 mu g/mL), addition of BA inhibited IL-17 and IFN-gamma production in a dose-dependent manner. The estimated IC50 values for IL-17 and IFN gamma were 11.2 and 63.8 mu mol/L, respectively. When the macrophages were stimulated with LPS (10 ng/mL), addition of BA (50 mu mol/L) significantly increased ROS generation, and suppressed NO generation. The astrocytes were stimulated with ConASn containing numerous inflammatory mediators, which mimicked the inflammatory milieu within CNS; addition of BA (50 mu mol/L) significantly increased ROS generation, and blocked ConASn-induced increases in iNOS and CXCL12 mRNA levels, but did not affect iNOS and CXCL12 protein levels. Importantly, in both the macrophages and astrocytes, addition of BA (50 mu mol/L) inhibited lipid peroxidation. Conclusion: Besides inhibiting encephalitogenic T cell cytokines and reducing NO generation, BA induces tissue-damaging ROS generation within CNS.",
journal = "Acta Pharmacologica Sinica",
title = "Betulinic acid regulates generation of neuroinflammatory mediators responsible for tissue destruction in multiple sclerosis in vitro",
number = "3",
volume = "34",
pages = "51-431",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1037"
}

Blaževski, J., Petković, F., Momčilović, M., Paschke, R., Kaluđerović, G. N., Mostarica-Stojković, M. B.,& Miljković, Đ.. (2013). Betulinic acid regulates generation of neuroinflammatory mediators responsible for tissue destruction in multiple sclerosis in vitro. in Acta Pharmacologica Sinica, 34(3), 51-431.
https://hdl.handle.net/21.15107/rcub_ibiss_1037

Blaževski J, Petković F, Momčilović M, Paschke R, Kaluđerović GN, Mostarica-Stojković MB, Miljković Đ. Betulinic acid regulates generation of neuroinflammatory mediators responsible for tissue destruction in multiple sclerosis in vitro. in Acta Pharmacologica Sinica. 2013;34(3):51-431.
https://hdl.handle.net/21.15107/rcub_ibiss_1037 .

Blaževski, Jana, Petković, Filip, Momčilović, Miljana, Paschke, Reinhard, Kaluđerović, Goran N., Mostarica-Stojković, Marija B, Miljković, Đorđe, "Betulinic acid regulates generation of neuroinflammatory mediators responsible for tissue destruction in multiple sclerosis in vitro" in Acta Pharmacologica Sinica, 34, no. 3 (2013):51-431,
https://hdl.handle.net/21.15107/rcub_ibiss_1037 .

TY  - CONF
AU  - Bulatović, Mirna Z.
AU  - Bensing, C
AU  - Miljković, Đorđe
AU  - Mojić, Marija
AU  - Gomez-Ruiz, Santiago
AU  - Mijatović, Sanja
AU  - Maksimović-Ivanić, Danijela
AU  - Kaluđerović, Goran N.
PY  - 2013
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/967
C3  - European Journal of Cancer
T1  - Nanostructured silica functionalized with an organotin compound induces differentiation of B16 melanoma cells
IS  - null
VL  - 49
SP  - 164
EP  - S174
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_967
ER  - 

@conference{
author = "Bulatović, Mirna Z. and Bensing, C and Miljković, Đorđe and Mojić, Marija and Gomez-Ruiz, Santiago and Mijatović, Sanja and Maksimović-Ivanić, Danijela and Kaluđerović, Goran N.",
year = "2013",
journal = "European Journal of Cancer",
title = "Nanostructured silica functionalized with an organotin compound induces differentiation of B16 melanoma cells",
number = "null",
volume = "49",
pages = "164-S174",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_967"
}

Bulatović, M. Z., Bensing, C., Miljković, Đ., Mojić, M., Gomez-Ruiz, S., Mijatović, S., Maksimović-Ivanić, D.,& Kaluđerović, G. N.. (2013). Nanostructured silica functionalized with an organotin compound induces differentiation of B16 melanoma cells. in European Journal of Cancer, 49(null), 164-S174.
https://hdl.handle.net/21.15107/rcub_ibiss_967

Bulatović MZ, Bensing C, Miljković Đ, Mojić M, Gomez-Ruiz S, Mijatović S, Maksimović-Ivanić D, Kaluđerović GN. Nanostructured silica functionalized with an organotin compound induces differentiation of B16 melanoma cells. in European Journal of Cancer. 2013;49(null):164-S174.
https://hdl.handle.net/21.15107/rcub_ibiss_967 .

Bulatović, Mirna Z., Bensing, C, Miljković, Đorđe, Mojić, Marija, Gomez-Ruiz, Santiago, Mijatović, Sanja, Maksimović-Ivanić, Danijela, Kaluđerović, Goran N., "Nanostructured silica functionalized with an organotin compound induces differentiation of B16 melanoma cells" in European Journal of Cancer, 49, no. null (2013):164-S174,
https://hdl.handle.net/21.15107/rcub_ibiss_967 .

TY  - JOUR
AU  - Ludwig, Gerd
AU  - Mijatović, Sanja
AU  - Ranđelović, Ivan
AU  - Bulatović, Mirna Z.
AU  - Miljković, Đorđe
AU  - Maksimović-Ivanić, Danijela
AU  - Korb, Marcus
AU  - Lang, Heinrich
AU  - Steinborn, Dirk
AU  - Kaluđerović, Goran N.
PY  - 2013
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/948
AB  - Neutral iridium(III) complexes of the type [Ir(eta(5)-C5Me5)Cl-2{Ph2PCH2S(O)(x)Ph-kappa P}] (1-3) with diphenylphosphino-functionalized methyl phenyl sulfides, sulfoxides, and sulfones Ph2PCH2S(O)(x)Ph (x = 0, L1; 1, 12; 2, L3) and the cationic complex [Ir(eta(5)-C5Me5)Cl(Ph2PCH2SPh-kappa P,kappa S}][PF6] (4) were synthesized and fully characterized analytically and spectroscopically. Furthermore, the structure of 2 was determined by X-ray diffraction analysis. The biological potential of the neutral and cationic iridium(III) complexes was tested in vitro against the cell lines 8505C, A253, MCF-7, SW480 and 518A2. Complex [Ir(eta(5)-C5Me5)Cl-2{Ph2PCH2S(O)Ph-kappa P}] (2), with ligand L2 kappa P coordinated containing a pendent sulfinyl group, is the most active one (IC50 values of about 3 mu M), thus, with activities comparable to cisplatin. Complex 2 proved to have an even a higher antiproliferative activity than cisplatin against 8505C and SW480 cell lines, used as a model system of highly anaplastic cancers with low sensitivity to conventional chemotherapeutics such as cisplatin. Additional experiments demonstrated that apoptosis and autophagic cell death contribute to the drug's tumoricidal action. (C) 2013 Elsevier Masson SAS. All rights reserved.
T2  - European Journal of Medicinal Chemistry
T1  - Biological activity of neutral and cationic iridium(III) complexes with kappa P and kappa P,kappa S coordinated Ph2PCH2S(O)(x)Ph (x=0-2) ligands
IS  - null
VL  - 69
SP  - 33
EP  - 222
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_948
ER  - 

@article{
author = "Ludwig, Gerd and Mijatović, Sanja and Ranđelović, Ivan and Bulatović, Mirna Z. and Miljković, Đorđe and Maksimović-Ivanić, Danijela and Korb, Marcus and Lang, Heinrich and Steinborn, Dirk and Kaluđerović, Goran N.",
year = "2013",
abstract = "Neutral iridium(III) complexes of the type [Ir(eta(5)-C5Me5)Cl-2{Ph2PCH2S(O)(x)Ph-kappa P}] (1-3) with diphenylphosphino-functionalized methyl phenyl sulfides, sulfoxides, and sulfones Ph2PCH2S(O)(x)Ph (x = 0, L1; 1, 12; 2, L3) and the cationic complex [Ir(eta(5)-C5Me5)Cl(Ph2PCH2SPh-kappa P,kappa S}][PF6] (4) were synthesized and fully characterized analytically and spectroscopically. Furthermore, the structure of 2 was determined by X-ray diffraction analysis. The biological potential of the neutral and cationic iridium(III) complexes was tested in vitro against the cell lines 8505C, A253, MCF-7, SW480 and 518A2. Complex [Ir(eta(5)-C5Me5)Cl-2{Ph2PCH2S(O)Ph-kappa P}] (2), with ligand L2 kappa P coordinated containing a pendent sulfinyl group, is the most active one (IC50 values of about 3 mu M), thus, with activities comparable to cisplatin. Complex 2 proved to have an even a higher antiproliferative activity than cisplatin against 8505C and SW480 cell lines, used as a model system of highly anaplastic cancers with low sensitivity to conventional chemotherapeutics such as cisplatin. Additional experiments demonstrated that apoptosis and autophagic cell death contribute to the drug's tumoricidal action. (C) 2013 Elsevier Masson SAS. All rights reserved.",
journal = "European Journal of Medicinal Chemistry",
title = "Biological activity of neutral and cationic iridium(III) complexes with kappa P and kappa P,kappa S coordinated Ph2PCH2S(O)(x)Ph (x=0-2) ligands",
number = "null",
volume = "69",
pages = "33-222",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_948"
}

Ludwig, G., Mijatović, S., Ranđelović, I., Bulatović, M. Z., Miljković, Đ., Maksimović-Ivanić, D., Korb, M., Lang, H., Steinborn, D.,& Kaluđerović, G. N.. (2013). Biological activity of neutral and cationic iridium(III) complexes with kappa P and kappa P,kappa S coordinated Ph2PCH2S(O)(x)Ph (x=0-2) ligands. in European Journal of Medicinal Chemistry, 69(null), 33-222.
https://hdl.handle.net/21.15107/rcub_ibiss_948

Ludwig G, Mijatović S, Ranđelović I, Bulatović MZ, Miljković Đ, Maksimović-Ivanić D, Korb M, Lang H, Steinborn D, Kaluđerović GN. Biological activity of neutral and cationic iridium(III) complexes with kappa P and kappa P,kappa S coordinated Ph2PCH2S(O)(x)Ph (x=0-2) ligands. in European Journal of Medicinal Chemistry. 2013;69(null):33-222.
https://hdl.handle.net/21.15107/rcub_ibiss_948 .

Ludwig, Gerd, Mijatović, Sanja, Ranđelović, Ivan, Bulatović, Mirna Z., Miljković, Đorđe, Maksimović-Ivanić, Danijela, Korb, Marcus, Lang, Heinrich, Steinborn, Dirk, Kaluđerović, Goran N., "Biological activity of neutral and cationic iridium(III) complexes with kappa P and kappa P,kappa S coordinated Ph2PCH2S(O)(x)Ph (x=0-2) ligands" in European Journal of Medicinal Chemistry, 69, no. null (2013):33-222,
https://hdl.handle.net/21.15107/rcub_ibiss_948 .

TY  - GEN
AU  - Kaluđerović, Goran N.
AU  - Gomez-Ruiz, Santiago
AU  - Maksimović-Ivanić, Danijela
AU  - Paschke, Reinhard
AU  - Mijatović, Sanja
PY  - 2012
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1225
T2  - Bioinorganic Chemistry and Applications
T1  - Metals in Medicine
IS  - null
VL  - null
EP  - na
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1225
ER  - 

@misc{
author = "Kaluđerović, Goran N. and Gomez-Ruiz, Santiago and Maksimović-Ivanić, Danijela and Paschke, Reinhard and Mijatović, Sanja",
year = "2012",
journal = "Bioinorganic Chemistry and Applications",
title = "Metals in Medicine",
number = "null",
volume = "null",
pages = "na",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1225"
}

Kaluđerović, G. N., Gomez-Ruiz, S., Maksimović-Ivanić, D., Paschke, R.,& Mijatović, S.. (2012). Metals in Medicine. in Bioinorganic Chemistry and Applications, null(null).
https://hdl.handle.net/21.15107/rcub_ibiss_1225

Kaluđerović GN, Gomez-Ruiz S, Maksimović-Ivanić D, Paschke R, Mijatović S. Metals in Medicine. in Bioinorganic Chemistry and Applications. 2012;null(null):null-na.
https://hdl.handle.net/21.15107/rcub_ibiss_1225 .

Kaluđerović, Goran N., Gomez-Ruiz, Santiago, Maksimović-Ivanić, Danijela, Paschke, Reinhard, Mijatović, Sanja, "Metals in Medicine" in Bioinorganic Chemistry and Applications, null, no. null (2012),
https://hdl.handle.net/21.15107/rcub_ibiss_1225 .

TY  - JOUR
AU  - Kaluđerović, Goran N.
AU  - Mijatović, Sanja
AU  - Zmejkovski, Bojana B
AU  - Bulatović, Mirna Z.
AU  - Gomez-Ruiz, Santiago
AU  - Mojić, Marija
AU  - Steinborn, Dirk
AU  - Miljković, Đorđe
AU  - Schmidt, Harry
AU  - Stošić-Grujičić, Stanislava
AU  - Sabo, Tibor J
AU  - Maksimović-Ivanić, Danijela
PY  - 2012
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1223
AB  - Several new R(2)eddp (R = i-Pr, i-Bu; eddp = ethylenediamine-N,N'-di-3-propionate) esters and corresponding platinum(II) and platinum(IV) complexes of the general formula [PtCln(R(2)edda-type)] (n = 2, 4) were synthesized and characterized by spectroscopic methods (IR, H-1 and C-13 NMR) and elemental analysis. The crystal structure of platinum(IV) complex [PtCl4{(c-Pe)(2)eddip}] (3a) was resolved and is given herein. Ligand precursors, platinum(II), and platinum(IV) complexes were tested against eight tumor cell lines (CT26CL25, HTC116, SW620, PC3, LNCaP, U251, A375, and B16). Selectivity in the action of those compounds between tumor and two normal primary cells (fibroblasts and keratinocytes) are discussed. A structure-activity relationship of these compounds is discussed. Furthermore, cell cycle distribution, induction of necrosis, apoptosis, autophagy, anoikis, caspase activation, ROS, and RNS are presented on the cisplatin-resistant colon carcinoma HCT116 cell line.
T2  - Metallomics
T1  - Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells
IS  - 9
VL  - 4
EP  - 987
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1223
ER  - 

@article{
author = "Kaluđerović, Goran N. and Mijatović, Sanja and Zmejkovski, Bojana B and Bulatović, Mirna Z. and Gomez-Ruiz, Santiago and Mojić, Marija and Steinborn, Dirk and Miljković, Đorđe and Schmidt, Harry and Stošić-Grujičić, Stanislava and Sabo, Tibor J and Maksimović-Ivanić, Danijela",
year = "2012",
abstract = "Several new R(2)eddp (R = i-Pr, i-Bu; eddp = ethylenediamine-N,N'-di-3-propionate) esters and corresponding platinum(II) and platinum(IV) complexes of the general formula [PtCln(R(2)edda-type)] (n = 2, 4) were synthesized and characterized by spectroscopic methods (IR, H-1 and C-13 NMR) and elemental analysis. The crystal structure of platinum(IV) complex [PtCl4{(c-Pe)(2)eddip}] (3a) was resolved and is given herein. Ligand precursors, platinum(II), and platinum(IV) complexes were tested against eight tumor cell lines (CT26CL25, HTC116, SW620, PC3, LNCaP, U251, A375, and B16). Selectivity in the action of those compounds between tumor and two normal primary cells (fibroblasts and keratinocytes) are discussed. A structure-activity relationship of these compounds is discussed. Furthermore, cell cycle distribution, induction of necrosis, apoptosis, autophagy, anoikis, caspase activation, ROS, and RNS are presented on the cisplatin-resistant colon carcinoma HCT116 cell line.",
journal = "Metallomics",
title = "Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells",
number = "9",
volume = "4",
pages = "987",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1223"
}

Kaluđerović, G. N., Mijatović, S., Zmejkovski, B. B., Bulatović, M. Z., Gomez-Ruiz, S., Mojić, M., Steinborn, D., Miljković, Đ., Schmidt, H., Stošić-Grujičić, S., Sabo, T. J.,& Maksimović-Ivanić, D.. (2012). Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells. in Metallomics, 4(9).
https://hdl.handle.net/21.15107/rcub_ibiss_1223

Kaluđerović GN, Mijatović S, Zmejkovski BB, Bulatović MZ, Gomez-Ruiz S, Mojić M, Steinborn D, Miljković Đ, Schmidt H, Stošić-Grujičić S, Sabo TJ, Maksimović-Ivanić D. Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells. in Metallomics. 2012;4(9):null-987.
https://hdl.handle.net/21.15107/rcub_ibiss_1223 .

Kaluđerović, Goran N., Mijatović, Sanja, Zmejkovski, Bojana B, Bulatović, Mirna Z., Gomez-Ruiz, Santiago, Mojić, Marija, Steinborn, Dirk, Miljković, Đorđe, Schmidt, Harry, Stošić-Grujičić, Stanislava, Sabo, Tibor J, Maksimović-Ivanić, Danijela, "Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells" in Metallomics, 4, no. 9 (2012),
https://hdl.handle.net/21.15107/rcub_ibiss_1223 .

TY  - JOUR
AU  - Mihajlović, Ljiljana E
AU  - Savić, Aleksandar R
AU  - Poljarević, Jelena M
AU  - Vucković, Ivan M
AU  - Mojić, Marija
AU  - Bulatović, Mirna Z.
AU  - Maksimović-Ivanić, Danijela
AU  - Mijatović, Sanja
AU  - Kaluđerović, Goran N.
AU  - Stošić-Grujičić, Stanislava
AU  - Miljković, Đorđe
AU  - Grgurić-Sipka, Sanja R
AU  - Sabo, Tibor J
PY  - 2012
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1195
AB  - This paper focuses on the synthesis, characterization and biological activity of new N,N'-methylene modified cyclohexyl ethylenediamine-N,N'-diacetate (edda)-type ligands and their Pt(IV) complexes. Both the ligands and complexes were characterized by infrared, UV-vis, ESI-MS, 1D (H-1, C-13, Pt-195) and 2D (COSY, HSQC, HMBC) NMR spectroscopy and elemental analysis. The possible correlation between the reduction potentials and the cytotoxicity of the complexes was examined. The potential antitumoral activity of all compounds was tested in vitro on human melanoma A375, human glioblastoma U251, human prostate cancer PC3, human colon cancer HCT116, mouse melanoma B16 and mouse colon cancer CT26CL25 cells, as well as primary fibroblasts and keratinocytes. The results obtained revealed strong antitumor potential of the newly synthesized drugs with preserved efficacy against cisplatin resistant lines and less toxicity towards nonmalignant counterparts. The mechanism found to be responsible for the observed tumoricidal action of each synthesized compound was induction of apoptosis generally accompanied with caspase activation. Taken together, the effective response to the treatment of a wide range of different cell lines, including cisplatin resistant subclones, as well as induction of apoptosis, as the mechanism suggested to be the most desirable way of eliminating malignant cells, represents a great advantage of this novel group of drugs in comparison to other members in this metallo-drug family. (C) 2012 Elsevier Inc. All rights reserved.
T2  - Journal of Inorganic Biochemistry
T1  - Novel methylene modified cyclohexyl ethylenediamine-N,N '-diacetate ligands and their platinum(IV) complexes. Influence on biological activity
IS  - null
VL  - 109
EP  - 48
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1195
ER  - 

@article{
author = "Mihajlović, Ljiljana E and Savić, Aleksandar R and Poljarević, Jelena M and Vucković, Ivan M and Mojić, Marija and Bulatović, Mirna Z. and Maksimović-Ivanić, Danijela and Mijatović, Sanja and Kaluđerović, Goran N. and Stošić-Grujičić, Stanislava and Miljković, Đorđe and Grgurić-Sipka, Sanja R and Sabo, Tibor J",
year = "2012",
abstract = "This paper focuses on the synthesis, characterization and biological activity of new N,N'-methylene modified cyclohexyl ethylenediamine-N,N'-diacetate (edda)-type ligands and their Pt(IV) complexes. Both the ligands and complexes were characterized by infrared, UV-vis, ESI-MS, 1D (H-1, C-13, Pt-195) and 2D (COSY, HSQC, HMBC) NMR spectroscopy and elemental analysis. The possible correlation between the reduction potentials and the cytotoxicity of the complexes was examined. The potential antitumoral activity of all compounds was tested in vitro on human melanoma A375, human glioblastoma U251, human prostate cancer PC3, human colon cancer HCT116, mouse melanoma B16 and mouse colon cancer CT26CL25 cells, as well as primary fibroblasts and keratinocytes. The results obtained revealed strong antitumor potential of the newly synthesized drugs with preserved efficacy against cisplatin resistant lines and less toxicity towards nonmalignant counterparts. The mechanism found to be responsible for the observed tumoricidal action of each synthesized compound was induction of apoptosis generally accompanied with caspase activation. Taken together, the effective response to the treatment of a wide range of different cell lines, including cisplatin resistant subclones, as well as induction of apoptosis, as the mechanism suggested to be the most desirable way of eliminating malignant cells, represents a great advantage of this novel group of drugs in comparison to other members in this metallo-drug family. (C) 2012 Elsevier Inc. All rights reserved.",
journal = "Journal of Inorganic Biochemistry",
title = "Novel methylene modified cyclohexyl ethylenediamine-N,N '-diacetate ligands and their platinum(IV) complexes. Influence on biological activity",
number = "null",
volume = "109",
pages = "48",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1195"
}

Mihajlović, L. E., Savić, A. R., Poljarević, J. M., Vucković, I. M., Mojić, M., Bulatović, M. Z., Maksimović-Ivanić, D., Mijatović, S., Kaluđerović, G. N., Stošić-Grujičić, S., Miljković, Đ., Grgurić-Sipka, S. R.,& Sabo, T. J.. (2012). Novel methylene modified cyclohexyl ethylenediamine-N,N '-diacetate ligands and their platinum(IV) complexes. Influence on biological activity. in Journal of Inorganic Biochemistry, 109(null).
https://hdl.handle.net/21.15107/rcub_ibiss_1195

Mihajlović LE, Savić AR, Poljarević JM, Vucković IM, Mojić M, Bulatović MZ, Maksimović-Ivanić D, Mijatović S, Kaluđerović GN, Stošić-Grujičić S, Miljković Đ, Grgurić-Sipka SR, Sabo TJ. Novel methylene modified cyclohexyl ethylenediamine-N,N '-diacetate ligands and their platinum(IV) complexes. Influence on biological activity. in Journal of Inorganic Biochemistry. 2012;109(null):null-48.
https://hdl.handle.net/21.15107/rcub_ibiss_1195 .

Mihajlović, Ljiljana E, Savić, Aleksandar R, Poljarević, Jelena M, Vucković, Ivan M, Mojić, Marija, Bulatović, Mirna Z., Maksimović-Ivanić, Danijela, Mijatović, Sanja, Kaluđerović, Goran N., Stošić-Grujičić, Stanislava, Miljković, Đorđe, Grgurić-Sipka, Sanja R, Sabo, Tibor J, "Novel methylene modified cyclohexyl ethylenediamine-N,N '-diacetate ligands and their platinum(IV) complexes. Influence on biological activity" in Journal of Inorganic Biochemistry, 109, no. null (2012),
https://hdl.handle.net/21.15107/rcub_ibiss_1195 .

TY  - JOUR
AU  - Gomez-Ruiz, Santiago
AU  - Maksimović-Ivanić, Danijela
AU  - Mijatović, Sanja
AU  - Kaluđerović, Goran N.
PY  - 2012
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1224
AB  - The purpose of this paper is to summarize mode of action of cisplatin on the tumor cells, a brief outlook on the metallocene compounds as antitumor drugs as well as the future tendencies for the use of the latter in anticancer chemotherapy. Molecular mechanisms of cisplatin interaction with DNA, DNA repair mechanisms, and cellular proteins are discussed. Molecular background of the sensitivity and resistance to cisplatin, as well as its influence on the efficacy of the antitumor immune response was evaluated. Furthermore, herein are summarized some metallocenes (titanocene, vanadocene, molybdocene, ferrocene, and zirconocene) with high antitumor activity.
T2  - Bioinorganic Chemistry and Applications
T1  - On the Discovery, Biological Effects, and Use of Cisplatin and Metallocenes in Anticancer Chemotherapy
IS  - null
VL  - null
EP  - na
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1224
ER  - 

@article{
author = "Gomez-Ruiz, Santiago and Maksimović-Ivanić, Danijela and Mijatović, Sanja and Kaluđerović, Goran N.",
year = "2012",
abstract = "The purpose of this paper is to summarize mode of action of cisplatin on the tumor cells, a brief outlook on the metallocene compounds as antitumor drugs as well as the future tendencies for the use of the latter in anticancer chemotherapy. Molecular mechanisms of cisplatin interaction with DNA, DNA repair mechanisms, and cellular proteins are discussed. Molecular background of the sensitivity and resistance to cisplatin, as well as its influence on the efficacy of the antitumor immune response was evaluated. Furthermore, herein are summarized some metallocenes (titanocene, vanadocene, molybdocene, ferrocene, and zirconocene) with high antitumor activity.",
journal = "Bioinorganic Chemistry and Applications",
title = "On the Discovery, Biological Effects, and Use of Cisplatin and Metallocenes in Anticancer Chemotherapy",
number = "null",
volume = "null",
pages = "na",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1224"
}

Gomez-Ruiz, S., Maksimović-Ivanić, D., Mijatović, S.,& Kaluđerović, G. N.. (2012). On the Discovery, Biological Effects, and Use of Cisplatin and Metallocenes in Anticancer Chemotherapy. in Bioinorganic Chemistry and Applications, null(null).
https://hdl.handle.net/21.15107/rcub_ibiss_1224

Gomez-Ruiz S, Maksimović-Ivanić D, Mijatović S, Kaluđerović GN. On the Discovery, Biological Effects, and Use of Cisplatin and Metallocenes in Anticancer Chemotherapy. in Bioinorganic Chemistry and Applications. 2012;null(null):null-na.
https://hdl.handle.net/21.15107/rcub_ibiss_1224 .

Gomez-Ruiz, Santiago, Maksimović-Ivanić, Danijela, Mijatović, Sanja, Kaluđerović, Goran N., "On the Discovery, Biological Effects, and Use of Cisplatin and Metallocenes in Anticancer Chemotherapy" in Bioinorganic Chemistry and Applications, null, no. null (2012),
https://hdl.handle.net/21.15107/rcub_ibiss_1224 .

TY  - JOUR
AU  - Maksimović-Ivanić, Danijela
AU  - Mijatović, Sanja
AU  - Mirkov, Ivana
AU  - Stošić-Grujičić, Stanislava
AU  - Miljković, Đorđe
AU  - Sabo, Tibor J
AU  - Trajković, Vladimir S
AU  - Kaluđerović, Goran N.
PY  - 2012
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1088
AB  - Tetrachlorido(O,O'-dibutyl-ethylenediamine-N,N'-di-3-propionate)-platinum(IV) complex, [PtCl4(n-Bu(2)eddp)], was previously found to be effective against fibrosarcoma and glioma cell lines. Here we presented that [PtCl4(n-Bu(2)eddp)] strongly reduced the growth of B16 melanoma cells in vitro. Inhibition of cell viability was accompanied with induction of both necrotic and apoptotic cell death. In addition, [PtCl4(n-Bu(2)eddp)] concealed the expansion of tumors induced in syngeneic C57BI/6 mice without visible signs of nephrotoxicity.
T2  - Metallomics
T1  - Melanoma tumor inhibition by tetrachlorido(O,O '-dibutyl-ethylenediamine-N,N '-di-3-propionate)platinum(IV) complex: in vitro and in vivo investigations
IS  - 11
VL  - 4
SP  - 222
EP  - 1159
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1088
ER  - 

@article{
author = "Maksimović-Ivanić, Danijela and Mijatović, Sanja and Mirkov, Ivana and Stošić-Grujičić, Stanislava and Miljković, Đorđe and Sabo, Tibor J and Trajković, Vladimir S and Kaluđerović, Goran N.",
year = "2012",
abstract = "Tetrachlorido(O,O'-dibutyl-ethylenediamine-N,N'-di-3-propionate)-platinum(IV) complex, [PtCl4(n-Bu(2)eddp)], was previously found to be effective against fibrosarcoma and glioma cell lines. Here we presented that [PtCl4(n-Bu(2)eddp)] strongly reduced the growth of B16 melanoma cells in vitro. Inhibition of cell viability was accompanied with induction of both necrotic and apoptotic cell death. In addition, [PtCl4(n-Bu(2)eddp)] concealed the expansion of tumors induced in syngeneic C57BI/6 mice without visible signs of nephrotoxicity.",
journal = "Metallomics",
title = "Melanoma tumor inhibition by tetrachlorido(O,O '-dibutyl-ethylenediamine-N,N '-di-3-propionate)platinum(IV) complex: in vitro and in vivo investigations",
number = "11",
volume = "4",
pages = "222-1159",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1088"
}

Maksimović-Ivanić, D., Mijatović, S., Mirkov, I., Stošić-Grujičić, S., Miljković, Đ., Sabo, T. J., Trajković, V. S.,& Kaluđerović, G. N.. (2012). Melanoma tumor inhibition by tetrachlorido(O,O '-dibutyl-ethylenediamine-N,N '-di-3-propionate)platinum(IV) complex: in vitro and in vivo investigations. in Metallomics, 4(11), 222-1159.
https://hdl.handle.net/21.15107/rcub_ibiss_1088

Maksimović-Ivanić D, Mijatović S, Mirkov I, Stošić-Grujičić S, Miljković Đ, Sabo TJ, Trajković VS, Kaluđerović GN. Melanoma tumor inhibition by tetrachlorido(O,O '-dibutyl-ethylenediamine-N,N '-di-3-propionate)platinum(IV) complex: in vitro and in vivo investigations. in Metallomics. 2012;4(11):222-1159.
https://hdl.handle.net/21.15107/rcub_ibiss_1088 .

Maksimović-Ivanić, Danijela, Mijatović, Sanja, Mirkov, Ivana, Stošić-Grujičić, Stanislava, Miljković, Đorđe, Sabo, Tibor J, Trajković, Vladimir S, Kaluđerović, Goran N., "Melanoma tumor inhibition by tetrachlorido(O,O '-dibutyl-ethylenediamine-N,N '-di-3-propionate)platinum(IV) complex: in vitro and in vivo investigations" in Metallomics, 4, no. 11 (2012):222-1159,
https://hdl.handle.net/21.15107/rcub_ibiss_1088 .