TY  - JOUR
AU  - Marković, Jelena
AU  - Uskoković, Aleksandra
AU  - Grdović, Nevena
AU  - Dinić, Svetlana
AU  - Mihailović, Mirjana
AU  - Arambašić Jovanović, Jelena
AU  - Poznanović, Goran
AU  - Vidaković, Melita
PY  - 2015
UR  - http://www.ncbi.nlm.nih.gov/pubmed/25453873
UR  - http://www.scopus.com/inward/record.url?eid=2-s2.0-84921956361&partnerID=tZOtx3y1
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3176
AB  - Diabetes is characterized by a deficit in the number of functional pancreatic β-cells. Understanding the mechanisms that stimulate neogenesis of β-cells should contribute to improved maintenance of β-cell mass. Chemokine CXCL12 has recently become established as a novel β-cell growth factor, however the mechanisms controlling its expression require clarification. We investigated the proteins involved in the transcriptional regulation of the rat β-cell CXCL12 gene (Cxcl12). Using the electrophoretic mobility shift assay and chromatin immunoprecipitation, we established the in vitro and in vivo binding of C/EBPβ, C/EBPα, STAT3, p53, FOXO3a, and HMG I/Y to the Cxcl12 promoter. Co-immunoprecipitation experiments revealed protein-protein interactions between YY1 and PARP-1, FOXO3a and PARP-1, Sp1 and PARP-1, p53 and PARP-1, C/EBPβ and PARP-1, YY1 and p53, YY1 and FOXO3a, p53 and FOXO3a, Sp1 and FOXO3a, C/EBPβ and FOXO3a, C/EBPα and FOXO3a, Sp1 and STAT3. Our data lay the foundation for research into the interplay of signaling pathways that determine the β-cell Cxcl12 expression profile.
PB  - National Research Council of Canada
PB  - Ottawa: Canadian Science Publishing
T2  - Biochemistry and cell biology
T1  - Identification of transcription factors involved in the transcriptional regulation of the CXCL12 gene in rat pancreatic insulinoma Rin-5F cell line
IS  - 1
VL  - 93
DO  - 10.1139/bcb-2014-0104
SP  - 54
EP  - 62
ER  - 

@article{
author = "Marković, Jelena and Uskoković, Aleksandra and Grdović, Nevena and Dinić, Svetlana and Mihailović, Mirjana and Arambašić Jovanović, Jelena and Poznanović, Goran and Vidaković, Melita",
year = "2015",
abstract = "Diabetes is characterized by a deficit in the number of functional pancreatic β-cells. Understanding the mechanisms that stimulate neogenesis of β-cells should contribute to improved maintenance of β-cell mass. Chemokine CXCL12 has recently become established as a novel β-cell growth factor, however the mechanisms controlling its expression require clarification. We investigated the proteins involved in the transcriptional regulation of the rat β-cell CXCL12 gene (Cxcl12). Using the electrophoretic mobility shift assay and chromatin immunoprecipitation, we established the in vitro and in vivo binding of C/EBPβ, C/EBPα, STAT3, p53, FOXO3a, and HMG I/Y to the Cxcl12 promoter. Co-immunoprecipitation experiments revealed protein-protein interactions between YY1 and PARP-1, FOXO3a and PARP-1, Sp1 and PARP-1, p53 and PARP-1, C/EBPβ and PARP-1, YY1 and p53, YY1 and FOXO3a, p53 and FOXO3a, Sp1 and FOXO3a, C/EBPβ and FOXO3a, C/EBPα and FOXO3a, Sp1 and STAT3. Our data lay the foundation for research into the interplay of signaling pathways that determine the β-cell Cxcl12 expression profile.",
publisher = "National Research Council of Canada, Ottawa: Canadian Science Publishing",
journal = "Biochemistry and cell biology",
title = "Identification of transcription factors involved in the transcriptional regulation of the CXCL12 gene in rat pancreatic insulinoma Rin-5F cell line",
number = "1",
volume = "93",
doi = "10.1139/bcb-2014-0104",
pages = "54-62"
}

Marković, J., Uskoković, A., Grdović, N., Dinić, S., Mihailović, M., Arambašić Jovanović, J., Poznanović, G.,& Vidaković, M.. (2015). Identification of transcription factors involved in the transcriptional regulation of the CXCL12 gene in rat pancreatic insulinoma Rin-5F cell line. in Biochemistry and cell biology
National Research Council of Canada., 93(1), 54-62.
https://doi.org/10.1139/bcb-2014-0104

Marković J, Uskoković A, Grdović N, Dinić S, Mihailović M, Arambašić Jovanović J, Poznanović G, Vidaković M. Identification of transcription factors involved in the transcriptional regulation of the CXCL12 gene in rat pancreatic insulinoma Rin-5F cell line. in Biochemistry and cell biology. 2015;93(1):54-62.
doi:10.1139/bcb-2014-0104 .

Marković, Jelena, Uskoković, Aleksandra, Grdović, Nevena, Dinić, Svetlana, Mihailović, Mirjana, Arambašić Jovanović, Jelena, Poznanović, Goran, Vidaković, Melita, "Identification of transcription factors involved in the transcriptional regulation of the CXCL12 gene in rat pancreatic insulinoma Rin-5F cell line" in Biochemistry and cell biology, 93, no. 1 (2015):54-62,
https://doi.org/10.1139/bcb-2014-0104 . .

TY  - JOUR
AU  - Marković, Jelena
AU  - Grdović, Nevena
AU  - Dinić, Svetlana
AU  - Karan-Djurašević, Teodora
AU  - Uskoković, Aleksandra
AU  - Arambašić Jovanović, Jelena
AU  - Mihailović, Mirjana
AU  - Pavlović, Sonja
AU  - Poznanović, Goran
AU  - Vidaković, Melita
PY  - 2013
UR  - http://www.ncbi.nlm.nih.gov/pubmed/23555743
UR  - http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC3608566
UR  - http://journals.plos.org/plosone/article?id=10.1371/journal.
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3186
AB  - Despite significant progress, the molecular mechanisms responsible for pancreatic beta cell depletion and development of diabetes remain poorly defined. At present, there is no preventive measure against diabetes. The positive impact of CXCL12 expression on the pancreatic beta cell prosurvival phenotype initiated this study. Our aim was to provide novel insight into the regulation of rat CXCL12 gene (Cxcl12) transcription. The roles of poly(ADP-ribose) polymerase-1 (PARP-1) and transcription factor Yin Yang 1 (YY1) in Cxcl12 transcription were studied by examining their in vitro and in vivo binding affinities for the Cxcl12 promoter in a pancreatic beta cell line by the electrophoretic mobility shift assay and chromatin immunoprecipitation. The regulatory activities of PARP-1 and YY1 were assessed in transfection experiments using a reporter vector with a Cxcl12 promoter sequence driving luciferase gene expression. Experimental evidence for PARP-1 and YY1 revealed their trans-acting potential, wherein PARP-1 displayed an inhibitory, and YY1 a strong activating effect on Cxcl12 transcription. Streptozotocin (STZ)-induced general toxicity in pancreatic beta cells was followed by changes in Cxcl12 promoter regulation. PARP-1 binding to the Cxcl12 promoter during basal and in STZ-compromised conditions led us to conclude that PARP-1 regulates constitutive Cxcl12 expression. During the early stage of oxidative stress, YY1 exhibited less affinity toward the Cxcl12 promoter while PARP-1 displayed strong binding. These interactions were accompanied by Cxcl12 downregulation. In the later stages of oxidative stress and intensive pancreatic beta cell injury, YY1 was highly expressed and firmly bound to Cxcl12 promoter in contrast to PARP-1. These interactions resulted in higher Cxcl12 expression. The observed ability of PARP-1 to downregulate, and of YY1 to upregulate Cxcl12 promoter activity anticipates corresponding effects in the natural context where the functional interplay of these proteins could finely balance Cxcl12 transcription.
PB  - San Francisco: Public Library Science
T2  - PLOS One
T1  - PARP-1 and YY1 Are Important Novel Regulators of CXCL12 Gene Transcription in Rat Pancreatic Beta Cells
IS  - 3
VL  - 8
DO  - 10.1371/journal.pone.0059679
SP  - e59679
ER  - 

@article{
author = "Marković, Jelena and Grdović, Nevena and Dinić, Svetlana and Karan-Djurašević, Teodora and Uskoković, Aleksandra and Arambašić Jovanović, Jelena and Mihailović, Mirjana and Pavlović, Sonja and Poznanović, Goran and Vidaković, Melita",
year = "2013",
abstract = "Despite significant progress, the molecular mechanisms responsible for pancreatic beta cell depletion and development of diabetes remain poorly defined. At present, there is no preventive measure against diabetes. The positive impact of CXCL12 expression on the pancreatic beta cell prosurvival phenotype initiated this study. Our aim was to provide novel insight into the regulation of rat CXCL12 gene (Cxcl12) transcription. The roles of poly(ADP-ribose) polymerase-1 (PARP-1) and transcription factor Yin Yang 1 (YY1) in Cxcl12 transcription were studied by examining their in vitro and in vivo binding affinities for the Cxcl12 promoter in a pancreatic beta cell line by the electrophoretic mobility shift assay and chromatin immunoprecipitation. The regulatory activities of PARP-1 and YY1 were assessed in transfection experiments using a reporter vector with a Cxcl12 promoter sequence driving luciferase gene expression. Experimental evidence for PARP-1 and YY1 revealed their trans-acting potential, wherein PARP-1 displayed an inhibitory, and YY1 a strong activating effect on Cxcl12 transcription. Streptozotocin (STZ)-induced general toxicity in pancreatic beta cells was followed by changes in Cxcl12 promoter regulation. PARP-1 binding to the Cxcl12 promoter during basal and in STZ-compromised conditions led us to conclude that PARP-1 regulates constitutive Cxcl12 expression. During the early stage of oxidative stress, YY1 exhibited less affinity toward the Cxcl12 promoter while PARP-1 displayed strong binding. These interactions were accompanied by Cxcl12 downregulation. In the later stages of oxidative stress and intensive pancreatic beta cell injury, YY1 was highly expressed and firmly bound to Cxcl12 promoter in contrast to PARP-1. These interactions resulted in higher Cxcl12 expression. The observed ability of PARP-1 to downregulate, and of YY1 to upregulate Cxcl12 promoter activity anticipates corresponding effects in the natural context where the functional interplay of these proteins could finely balance Cxcl12 transcription.",
publisher = "San Francisco: Public Library Science",
journal = "PLOS One",
title = "PARP-1 and YY1 Are Important Novel Regulators of CXCL12 Gene Transcription in Rat Pancreatic Beta Cells",
number = "3",
volume = "8",
doi = "10.1371/journal.pone.0059679",
pages = "e59679"
}

Marković, J., Grdović, N., Dinić, S., Karan-Djurašević, T., Uskoković, A., Arambašić Jovanović, J., Mihailović, M., Pavlović, S., Poznanović, G.,& Vidaković, M.. (2013). PARP-1 and YY1 Are Important Novel Regulators of CXCL12 Gene Transcription in Rat Pancreatic Beta Cells. in PLOS One
San Francisco: Public Library Science., 8(3), e59679.
https://doi.org/10.1371/journal.pone.0059679

Marković J, Grdović N, Dinić S, Karan-Djurašević T, Uskoković A, Arambašić Jovanović J, Mihailović M, Pavlović S, Poznanović G, Vidaković M. PARP-1 and YY1 Are Important Novel Regulators of CXCL12 Gene Transcription in Rat Pancreatic Beta Cells. in PLOS One. 2013;8(3):e59679.
doi:10.1371/journal.pone.0059679 .

Marković, Jelena, Grdović, Nevena, Dinić, Svetlana, Karan-Djurašević, Teodora, Uskoković, Aleksandra, Arambašić Jovanović, Jelena, Mihailović, Mirjana, Pavlović, Sonja, Poznanović, Goran, Vidaković, Melita, "PARP-1 and YY1 Are Important Novel Regulators of CXCL12 Gene Transcription in Rat Pancreatic Beta Cells" in PLOS One, 8, no. 3 (2013):e59679,
https://doi.org/10.1371/journal.pone.0059679 . .

TY  - JOUR
AU  - Dinić, Svetlana
AU  - Arambašić Jovanović, Jelena
AU  - Mihailović, Mirjana
AU  - Uskoković, Aleksandra
AU  - Grdović, Nevena
AU  - Marković, Jelena
AU  - Karadžić, Borivoje
AU  - Poznanović, Goran
AU  - Vidaković, Melita
PY  - 2013
UR  - http://www.ncbi.nlm.nih.gov/pubmed/23312093
UR  - http://www.journals.cambridge.org/abstract_S0007114512005429
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3189
AB  - The present study aimed to investigate the effects of the treatment with a-lipoic acid (LA), a naturally occurring compound possessing antioxidant activity, on liver oxidant stress in a rat model of streptozotocin (STZ)-induced diabetes by examining potential mechanistic points that influence changes in the expression of antioxidant enzymes such as catalase (CAT) and CuZn/Mn superoxide dismutase(s) (SOD). LA was administered for 4 weeks by daily intraperitoneal injections (10 mg/kg) to STZ-induced diabetic rats, starting from the last STZ treatment. LA administration practically normalised the activities of the indicators of hepatocellular injury, alanine and aspartate aminotransferases, and lowered oxidative stress, as observed by the thiobarbituric acid-reactive substance assay, restored the reduced glutathione:glutathione disulphide ratio and increased the protein sulfhydryl group content. The lower level of DNA damage detected by the comet assay revealed that LA reduced cytotoxic signalling, exerting a hepatoprotective effect. The LA-treated diabetic rats displayed restored specific enzymatic activities of CAT, CuZnSOD and MnSOD. Quantitative real-time PCR analysis showed that LA restored CAT gene expression to its physiological level and increased CuZnSOD gene expression, but the gene expression of MnSOD remained at the diabetic level. Although the amounts of CAT and CuZnSOD protein expression returned to the control levels, the protein expression of MnSOD was elevated. These results suggested that LA administration affected CAT and CuZnSOD expression mainly at the transcriptional level, and MnSOD expression at the post-transcriptional level. The observed LA-promoted decrease in the O-GlcNAcylation of extracellular signal-regulated kinase, protein 38 kinase, NF-kB, CCAAT/enhancer-binding protein and the antioxidative enzymes themselves in diabetic rats suggests that the regulatory mechanisms that supported the changes in antioxidative enzyme expression were also influenced by post-translational mechanisms.
PB  - Cambridge University Press
T2  - The British Journal of Nutrition
T1  - Decreased O-GlcNAcylation of the key proteins in kinase and redox signalling pathways is a novel mechanism of the beneficial effect of α-lipoic acid in diabetic liver
IS  - 3
VL  - 110
DO  - 10.1017/S0007114512005429
SP  - 401
EP  - 12
ER  - 

@article{
author = "Dinić, Svetlana and Arambašić Jovanović, Jelena and Mihailović, Mirjana and Uskoković, Aleksandra and Grdović, Nevena and Marković, Jelena and Karadžić, Borivoje and Poznanović, Goran and Vidaković, Melita",
year = "2013",
abstract = "The present study aimed to investigate the effects of the treatment with a-lipoic acid (LA), a naturally occurring compound possessing antioxidant activity, on liver oxidant stress in a rat model of streptozotocin (STZ)-induced diabetes by examining potential mechanistic points that influence changes in the expression of antioxidant enzymes such as catalase (CAT) and CuZn/Mn superoxide dismutase(s) (SOD). LA was administered for 4 weeks by daily intraperitoneal injections (10 mg/kg) to STZ-induced diabetic rats, starting from the last STZ treatment. LA administration practically normalised the activities of the indicators of hepatocellular injury, alanine and aspartate aminotransferases, and lowered oxidative stress, as observed by the thiobarbituric acid-reactive substance assay, restored the reduced glutathione:glutathione disulphide ratio and increased the protein sulfhydryl group content. The lower level of DNA damage detected by the comet assay revealed that LA reduced cytotoxic signalling, exerting a hepatoprotective effect. The LA-treated diabetic rats displayed restored specific enzymatic activities of CAT, CuZnSOD and MnSOD. Quantitative real-time PCR analysis showed that LA restored CAT gene expression to its physiological level and increased CuZnSOD gene expression, but the gene expression of MnSOD remained at the diabetic level. Although the amounts of CAT and CuZnSOD protein expression returned to the control levels, the protein expression of MnSOD was elevated. These results suggested that LA administration affected CAT and CuZnSOD expression mainly at the transcriptional level, and MnSOD expression at the post-transcriptional level. The observed LA-promoted decrease in the O-GlcNAcylation of extracellular signal-regulated kinase, protein 38 kinase, NF-kB, CCAAT/enhancer-binding protein and the antioxidative enzymes themselves in diabetic rats suggests that the regulatory mechanisms that supported the changes in antioxidative enzyme expression were also influenced by post-translational mechanisms.",
publisher = "Cambridge University Press",
journal = "The British Journal of Nutrition",
title = "Decreased O-GlcNAcylation of the key proteins in kinase and redox signalling pathways is a novel mechanism of the beneficial effect of α-lipoic acid in diabetic liver",
number = "3",
volume = "110",
doi = "10.1017/S0007114512005429",
pages = "401-12"
}

Dinić, S., Arambašić Jovanović, J., Mihailović, M., Uskoković, A., Grdović, N., Marković, J., Karadžić, B., Poznanović, G.,& Vidaković, M.. (2013). Decreased O-GlcNAcylation of the key proteins in kinase and redox signalling pathways is a novel mechanism of the beneficial effect of α-lipoic acid in diabetic liver. in The British Journal of Nutrition
Cambridge University Press., 110(3), 401-12.
https://doi.org/10.1017/S0007114512005429

Dinić S, Arambašić Jovanović J, Mihailović M, Uskoković A, Grdović N, Marković J, Karadžić B, Poznanović G, Vidaković M. Decreased O-GlcNAcylation of the key proteins in kinase and redox signalling pathways is a novel mechanism of the beneficial effect of α-lipoic acid in diabetic liver. in The British Journal of Nutrition. 2013;110(3):401-12.
doi:10.1017/S0007114512005429 .

Dinić, Svetlana, Arambašić Jovanović, Jelena, Mihailović, Mirjana, Uskoković, Aleksandra, Grdović, Nevena, Marković, Jelena, Karadžić, Borivoje, Poznanović, Goran, Vidaković, Melita, "Decreased O-GlcNAcylation of the key proteins in kinase and redox signalling pathways is a novel mechanism of the beneficial effect of α-lipoic acid in diabetic liver" in The British Journal of Nutrition, 110, no. 3 (2013):401-12,
https://doi.org/10.1017/S0007114512005429 . .

TY  - JOUR
AU  - Arambašić Jovanović, Jelena
AU  - Mihailović, Mirjana
AU  - Uskoković, Aleksandra
AU  - Dinić, Svetlana
AU  - Grdović, Nevena
AU  - Marković, Jelena
AU  - Poznanović, Goran
AU  - Bajec, Đorđe
AU  - Vidaković, Melita
PY  - 2013
UR  - http://link.springer.com/10.1007/s00394-012-0452-z
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3190
AB  - PURPOSE: The combined hyperglycemia lowering and antioxidant actions of α-lipoic acid (LA) contribute to its usefulness in preventing renal injury and other diabetic complications. The precise mechanisms by which LA alters diabetic oxidative renal injury are not known. We hypothesized that LA through its hypoglycemic effect lowers O-GlcNAcylation which influences the expression and activities of antioxidant enzymes which assume important roles in preventing diabetes-induced oxidative renal injury.\n\nMETHODS: An experimental model of diabetes was induced in rats by the administration of 40 mg/kg streptozotocin (STZ) intraperitoneally (i.p.) for five consecutive days. LA was applied at a dose of 10 mg/kg i.p. for 4 weeks, starting from the last day of STZ administration.\n\nRESULTS: An improved glycemic status of LA-treated diabetic rats was accompanied by a significant suppression of oxidative stress and a reduction of oxidative damage of lipids, proteins and DNA. LA treatment normalized CuZn-superoxide dismutase (SOD) and catalase activities in renal tissue of diabetic rats. These changes were allied with upregulated gene expression and lower levels of O-GlcNA glycosylation. The accompanying increase in MnSOD activity was only linked with upregulated gene expression. The observed antioxidant enzyme gene regulation was accompanied by nuclear translocation of Nuclear factor-erythroid-2-related factor 2 (Nrf2), enhanced expression of heat shock proteins (HSPs) and by reduction in O-GlcNAcylation of HSP90, HSP70, and extracellular regulated kinase and p38.\n\nCONCLUSION: α-Lipoic acid administration activates a coordinated cytoprotective response against diabetes-induced oxidative injury in kidney tissue through an O-GlcNAc-dependent mechanism.
PB  - Springer Nature
T2  - European Journal of Nutrition
T1  - Alpha-lipoic acid upregulates antioxidant enzyme gene expression and enzymatic activity in diabetic rat kidneys through an O-GlcNAc-dependent mechanism
IS  - 5
VL  - 52
DO  - 10.1007/s00394-012-0452-z
SP  - 1461
EP  - 1473
ER  - 

@article{
author = "Arambašić Jovanović, Jelena and Mihailović, Mirjana and Uskoković, Aleksandra and Dinić, Svetlana and Grdović, Nevena and Marković, Jelena and Poznanović, Goran and Bajec, Đorđe and Vidaković, Melita",
year = "2013",
abstract = "PURPOSE: The combined hyperglycemia lowering and antioxidant actions of α-lipoic acid (LA) contribute to its usefulness in preventing renal injury and other diabetic complications. The precise mechanisms by which LA alters diabetic oxidative renal injury are not known. We hypothesized that LA through its hypoglycemic effect lowers O-GlcNAcylation which influences the expression and activities of antioxidant enzymes which assume important roles in preventing diabetes-induced oxidative renal injury.\n\nMETHODS: An experimental model of diabetes was induced in rats by the administration of 40 mg/kg streptozotocin (STZ) intraperitoneally (i.p.) for five consecutive days. LA was applied at a dose of 10 mg/kg i.p. for 4 weeks, starting from the last day of STZ administration.\n\nRESULTS: An improved glycemic status of LA-treated diabetic rats was accompanied by a significant suppression of oxidative stress and a reduction of oxidative damage of lipids, proteins and DNA. LA treatment normalized CuZn-superoxide dismutase (SOD) and catalase activities in renal tissue of diabetic rats. These changes were allied with upregulated gene expression and lower levels of O-GlcNA glycosylation. The accompanying increase in MnSOD activity was only linked with upregulated gene expression. The observed antioxidant enzyme gene regulation was accompanied by nuclear translocation of Nuclear factor-erythroid-2-related factor 2 (Nrf2), enhanced expression of heat shock proteins (HSPs) and by reduction in O-GlcNAcylation of HSP90, HSP70, and extracellular regulated kinase and p38.\n\nCONCLUSION: α-Lipoic acid administration activates a coordinated cytoprotective response against diabetes-induced oxidative injury in kidney tissue through an O-GlcNAc-dependent mechanism.",
publisher = "Springer Nature",
journal = "European Journal of Nutrition",
title = "Alpha-lipoic acid upregulates antioxidant enzyme gene expression and enzymatic activity in diabetic rat kidneys through an O-GlcNAc-dependent mechanism",
number = "5",
volume = "52",
doi = "10.1007/s00394-012-0452-z",
pages = "1461-1473"
}

Arambašić Jovanović, J., Mihailović, M., Uskoković, A., Dinić, S., Grdović, N., Marković, J., Poznanović, G., Bajec, Đ.,& Vidaković, M.. (2013). Alpha-lipoic acid upregulates antioxidant enzyme gene expression and enzymatic activity in diabetic rat kidneys through an O-GlcNAc-dependent mechanism. in European Journal of Nutrition
Springer Nature., 52(5), 1461-1473.
https://doi.org/10.1007/s00394-012-0452-z

Arambašić Jovanović J, Mihailović M, Uskoković A, Dinić S, Grdović N, Marković J, Poznanović G, Bajec Đ, Vidaković M. Alpha-lipoic acid upregulates antioxidant enzyme gene expression and enzymatic activity in diabetic rat kidneys through an O-GlcNAc-dependent mechanism. in European Journal of Nutrition. 2013;52(5):1461-1473.
doi:10.1007/s00394-012-0452-z .

Arambašić Jovanović, Jelena, Mihailović, Mirjana, Uskoković, Aleksandra, Dinić, Svetlana, Grdović, Nevena, Marković, Jelena, Poznanović, Goran, Bajec, Đorđe, Vidaković, Melita, "Alpha-lipoic acid upregulates antioxidant enzyme gene expression and enzymatic activity in diabetic rat kidneys through an O-GlcNAc-dependent mechanism" in European Journal of Nutrition, 52, no. 5 (2013):1461-1473,
https://doi.org/10.1007/s00394-012-0452-z . .

TY  - JOUR
AU  - Uskoković, Aleksandra
AU  - Mihailović, Mirjana
AU  - Dinić, Svetlana
AU  - Arambašić Jovanović, Jelena
AU  - Grdović, Nevena
AU  - Marković, Jelena
AU  - Poznanović, Goran
AU  - Vidaković, Melita
PY  - 2013
UR  - http://linkinghub.elsevier.com/retrieve/pii/S175646461300217X
UR  - http://www.sciencedirect.com/science/article/pii/S175646461300217X
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3187
AB  - The beneficial effect of a commercially available β-glucan-enriched extract (BGEE) from cereal grain, against a diabetes-induced hepatic redox imbalance and inflammatory response in streptozotocin-induced diabetic rats was evaluated. Diabetic rats that were treated with BGEE exhibited lower hyperglycaemia and improved biochemical parameters of liver damage. BGEE attenuated hepatic oxidative stress, revealed by a decreased concentration of thiobarbituric acid reactive substances and a restored GSH/GSSG ratio. BGEE also exerted an anti-inflammatory effect on the liver, evidenced by the normalization of the serum concentrations of the "positive" and "negative" acute-phase proteins, α2-macroglobulin and albumin, respectively, as well as by upregulation of anti-inflammatory cytokine IL-10 and IL-4 mRNA expression, and inhibition of RAGE/NF-κB signaling. These findings suggest that BGEE application exerts a beneficial effect in the liver of streptozotocin-induced diabetic rats via its antioxidant and anti-inflammatory activities, and that it therefore possesses an important potential in diabetes management. © 2013 Elsevier Ltd.
PB  - Elsevier
T2  - Journal of Functional Foods
T1  - Administration of a β-glucan-enriched extract activates beneficial hepatic antioxidant and anti-inflammatory mechanisms in streptozotocin-induced diabetic rats
IS  - 4
VL  - 5
DO  - 10.1016/j.jff.2013.09.018
SP  - 1966
EP  - 1974
ER  - 

@article{
author = "Uskoković, Aleksandra and Mihailović, Mirjana and Dinić, Svetlana and Arambašić Jovanović, Jelena and Grdović, Nevena and Marković, Jelena and Poznanović, Goran and Vidaković, Melita",
year = "2013",
abstract = "The beneficial effect of a commercially available β-glucan-enriched extract (BGEE) from cereal grain, against a diabetes-induced hepatic redox imbalance and inflammatory response in streptozotocin-induced diabetic rats was evaluated. Diabetic rats that were treated with BGEE exhibited lower hyperglycaemia and improved biochemical parameters of liver damage. BGEE attenuated hepatic oxidative stress, revealed by a decreased concentration of thiobarbituric acid reactive substances and a restored GSH/GSSG ratio. BGEE also exerted an anti-inflammatory effect on the liver, evidenced by the normalization of the serum concentrations of the "positive" and "negative" acute-phase proteins, α2-macroglobulin and albumin, respectively, as well as by upregulation of anti-inflammatory cytokine IL-10 and IL-4 mRNA expression, and inhibition of RAGE/NF-κB signaling. These findings suggest that BGEE application exerts a beneficial effect in the liver of streptozotocin-induced diabetic rats via its antioxidant and anti-inflammatory activities, and that it therefore possesses an important potential in diabetes management. © 2013 Elsevier Ltd.",
publisher = "Elsevier",
journal = "Journal of Functional Foods",
title = "Administration of a β-glucan-enriched extract activates beneficial hepatic antioxidant and anti-inflammatory mechanisms in streptozotocin-induced diabetic rats",
number = "4",
volume = "5",
doi = "10.1016/j.jff.2013.09.018",
pages = "1966-1974"
}

Uskoković, A., Mihailović, M., Dinić, S., Arambašić Jovanović, J., Grdović, N., Marković, J., Poznanović, G.,& Vidaković, M.. (2013). Administration of a β-glucan-enriched extract activates beneficial hepatic antioxidant and anti-inflammatory mechanisms in streptozotocin-induced diabetic rats. in Journal of Functional Foods
Elsevier., 5(4), 1966-1974.
https://doi.org/10.1016/j.jff.2013.09.018

Uskoković A, Mihailović M, Dinić S, Arambašić Jovanović J, Grdović N, Marković J, Poznanović G, Vidaković M. Administration of a β-glucan-enriched extract activates beneficial hepatic antioxidant and anti-inflammatory mechanisms in streptozotocin-induced diabetic rats. in Journal of Functional Foods. 2013;5(4):1966-1974.
doi:10.1016/j.jff.2013.09.018 .

Uskoković, Aleksandra, Mihailović, Mirjana, Dinić, Svetlana, Arambašić Jovanović, Jelena, Grdović, Nevena, Marković, Jelena, Poznanović, Goran, Vidaković, Melita, "Administration of a β-glucan-enriched extract activates beneficial hepatic antioxidant and anti-inflammatory mechanisms in streptozotocin-induced diabetic rats" in Journal of Functional Foods, 5, no. 4 (2013):1966-1974,
https://doi.org/10.1016/j.jff.2013.09.018 . .

TY  - JOUR
AU  - Mihailović, Mirjana
AU  - Arambašić Jovanović, Jelena
AU  - Uskoković, Aleksandra
AU  - Dinić, Svetlana
AU  - Grdović, Nevena
AU  - Marković, Jelena
AU  - Mujić, Ibrahim
AU  - Šijački, Ana D.
AU  - Poznanović, Goran
AU  - Vidaković, Melita
PY  - 2013
UR  - http://search.crossref.org/?q=10.1016%2Fj.jff.2012.10.016+
UR  - http://linkinghub.elsevier.com/retrieve/pii/S1756464612001624
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3183
AB  - The mechanisms underlying the beneficial effect observed in diabetic rats after treatment with a commercially available β-glucan-enriched extract (BGEE) were examined. Multiple low-dose streptozotocin (STZ) diabetes was used (40 mg STZ/kg) as a model for type 1 diabetes. BGEE was administered daily (80 mg/kg) for 4 weeks, starting from the last day of the STZ treatment. In vitro and in vivo experiments suggest that significant free radical scavenging and antioxidant activities of BGEE were responsible for a systemic adjustment of the redox disturbance and reduction of DNA damage in the liver and kidney of diabetic rats. BGEE-treated diabetic rats also displayed increased Akt kinase activity and decreased pro-caspase-3 degradation, implying that BGEE mediates its beneficial effects through activation of the cellular pro-survival pathway. We conclude that β-glucan administration under diabetic conditions promotes a systemic improvement that can be expected to increase the organism’s resistance to the onset of diabetic complications.
PB  - Elsevier
T2  - Journal of Functional Foods
T1  - β-Glucan administration to diabetic rats reestablishes redox balance and stimulates cellular pro-survival mechanisms
IS  - 1
VL  - 5
DO  - 10.1016/j.jff.2012.10.016
SP  - 267
EP  - 278
ER  - 

@article{
author = "Mihailović, Mirjana and Arambašić Jovanović, Jelena and Uskoković, Aleksandra and Dinić, Svetlana and Grdović, Nevena and Marković, Jelena and Mujić, Ibrahim and Šijački, Ana D. and Poznanović, Goran and Vidaković, Melita",
year = "2013",
abstract = "The mechanisms underlying the beneficial effect observed in diabetic rats after treatment with a commercially available β-glucan-enriched extract (BGEE) were examined. Multiple low-dose streptozotocin (STZ) diabetes was used (40 mg STZ/kg) as a model for type 1 diabetes. BGEE was administered daily (80 mg/kg) for 4 weeks, starting from the last day of the STZ treatment. In vitro and in vivo experiments suggest that significant free radical scavenging and antioxidant activities of BGEE were responsible for a systemic adjustment of the redox disturbance and reduction of DNA damage in the liver and kidney of diabetic rats. BGEE-treated diabetic rats also displayed increased Akt kinase activity and decreased pro-caspase-3 degradation, implying that BGEE mediates its beneficial effects through activation of the cellular pro-survival pathway. We conclude that β-glucan administration under diabetic conditions promotes a systemic improvement that can be expected to increase the organism’s resistance to the onset of diabetic complications.",
publisher = "Elsevier",
journal = "Journal of Functional Foods",
title = "β-Glucan administration to diabetic rats reestablishes redox balance and stimulates cellular pro-survival mechanisms",
number = "1",
volume = "5",
doi = "10.1016/j.jff.2012.10.016",
pages = "267-278"
}

Mihailović, M., Arambašić Jovanović, J., Uskoković, A., Dinić, S., Grdović, N., Marković, J., Mujić, I., Šijački, A. D., Poznanović, G.,& Vidaković, M.. (2013). β-Glucan administration to diabetic rats reestablishes redox balance and stimulates cellular pro-survival mechanisms. in Journal of Functional Foods
Elsevier., 5(1), 267-278.
https://doi.org/10.1016/j.jff.2012.10.016

Mihailović M, Arambašić Jovanović J, Uskoković A, Dinić S, Grdović N, Marković J, Mujić I, Šijački AD, Poznanović G, Vidaković M. β-Glucan administration to diabetic rats reestablishes redox balance and stimulates cellular pro-survival mechanisms. in Journal of Functional Foods. 2013;5(1):267-278.
doi:10.1016/j.jff.2012.10.016 .

Mihailović, Mirjana, Arambašić Jovanović, Jelena, Uskoković, Aleksandra, Dinić, Svetlana, Grdović, Nevena, Marković, Jelena, Mujić, Ibrahim, Šijački, Ana D., Poznanović, Goran, Vidaković, Melita, "β-Glucan administration to diabetic rats reestablishes redox balance and stimulates cellular pro-survival mechanisms" in Journal of Functional Foods, 5, no. 1 (2013):267-278,
https://doi.org/10.1016/j.jff.2012.10.016 . .

TY  - JOUR
AU  - Dinić, Svetlana
AU  - Uskoković, Aleksandra
AU  - Mihailović, Mirjana
AU  - Grdović, Nevena
AU  - Arambašić Jovanović, Jelena
AU  - Marković, Jelena
AU  - Poznanović, Goran
AU  - Vidaković, Melita
PY  - 2013
PY  - 2013
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/565
AB  - Given that oxidative stress plays a major role in pancreatic β-cell dysfunction and ultimate destruction, as well as in different complications of diabetes, therapy with antioxidants has assumed an important place in the management of diabetes. The relatively limited effects of established antioxidant compounds have stimulated efforts to develop new therapeutic strategies, e.g. to increase the endogenous antioxidant defences through pharmacological modulation of key antioxidant enzymes. Plant extracts are gaining popularity in treating diabetes because many substances synthesized by higher plants and fungi possess antioxidant activities and can prevent or protect tissues against the damaging effects of free radicals. This review summarizes experimental models of diabetes and possible mechanisms that lie behind the antioxidative effects of α-lipoic acid (LA), a powerful antioxidant and compound that stimulates cellular glucose uptake, as well as of plant extracts from sweet chestnut (Castanea sativa), edible mushroom (Lactarius deterrimus) and natural products containing β-glucans in the treatment of diabetes. Their roles in preventing pancreatic β-cell death and in ameliorating the effects of severe diabetic complications are discussed.
AB  - Terapija antioksidansima zauzima značajno mesto u lečenju dijabetesa s obzirom da oksidativni stres u velikoj meri doprinosi narušavanju funkcije i strukture β-ćelija pankreasa kao i razvoju komplikacija u dijabetesu. Zbog ograničenog dejstva postojećih antioksidativnih jedinjenja traga se za novim terapijskim rešenjima u tretmanu dijabetesa, kao što je povećanje endogene antioksidativne zaštite organizma putem farmakološke modulacije ključnih antioksidativnih enzima. Primena biljnih ekstrakata u lečenju dijabetesa postaje sve popularnija. Mnoge supstance koje se nalaze u sastavu viših biljaka i gljiva poseduju antioksidativna svojstva koja mogu da zaštite tkiva od štetnih uticaja slobodnih radikala. U ovom revijalnom radu opisani su eksperimentalni modeli dijabetesa kao i mogući mehanizmi koji leže u osnovi antioksidativnog dejstva α-liponske kiseline (LA), snažnog antioksidansa i jedinjenja koje stimuliše ćelijsku apsorpciju glukoze, kao i biljnih ekstrakata izolovanih iz slatkog kestena (Castanea sativa), jestivih pečuraka (Lactarius deterrimus) i prirodnih proizvoda koji sadrže β-glukan u lečenju dijabetesa. Opisani su njihova uloga u sprečavanju smrti β-ćelija pankreasa kao i blagotvorno dejstvo na komplikacije u dijabetesu.
PB  - Belgrade: Serbian Chemical Society
PB  - © 2013 by the Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Pozitivno dejstvo antioksidativnih jedinjenja iz biljnih ekstrakata u eksperimentalnom modelu dijabetesa
T1  - Ameliorating effects of antioxidative compounds from four plant extracts in experimental models of diabetes
IS  - 3
VL  - 78
DO  - 10.2298/JSC121026136D
SP  - 365
EP  - 380
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_565
ER  - 

@article{
author = "Dinić, Svetlana and Uskoković, Aleksandra and Mihailović, Mirjana and Grdović, Nevena and Arambašić Jovanović, Jelena and Marković, Jelena and Poznanović, Goran and Vidaković, Melita",
year = "2013, 2013",
abstract = "Given that oxidative stress plays a major role in pancreatic β-cell dysfunction and ultimate destruction, as well as in different complications of diabetes, therapy with antioxidants has assumed an important place in the management of diabetes. The relatively limited effects of established antioxidant compounds have stimulated efforts to develop new therapeutic strategies, e.g. to increase the endogenous antioxidant defences through pharmacological modulation of key antioxidant enzymes. Plant extracts are gaining popularity in treating diabetes because many substances synthesized by higher plants and fungi possess antioxidant activities and can prevent or protect tissues against the damaging effects of free radicals. This review summarizes experimental models of diabetes and possible mechanisms that lie behind the antioxidative effects of α-lipoic acid (LA), a powerful antioxidant and compound that stimulates cellular glucose uptake, as well as of plant extracts from sweet chestnut (Castanea sativa), edible mushroom (Lactarius deterrimus) and natural products containing β-glucans in the treatment of diabetes. Their roles in preventing pancreatic β-cell death and in ameliorating the effects of severe diabetic complications are discussed., Terapija antioksidansima zauzima značajno mesto u lečenju dijabetesa s obzirom da oksidativni stres u velikoj meri doprinosi narušavanju funkcije i strukture β-ćelija pankreasa kao i razvoju komplikacija u dijabetesu. Zbog ograničenog dejstva postojećih antioksidativnih jedinjenja traga se za novim terapijskim rešenjima u tretmanu dijabetesa, kao što je povećanje endogene antioksidativne zaštite organizma putem farmakološke modulacije ključnih antioksidativnih enzima. Primena biljnih ekstrakata u lečenju dijabetesa postaje sve popularnija. Mnoge supstance koje se nalaze u sastavu viših biljaka i gljiva poseduju antioksidativna svojstva koja mogu da zaštite tkiva od štetnih uticaja slobodnih radikala. U ovom revijalnom radu opisani su eksperimentalni modeli dijabetesa kao i mogući mehanizmi koji leže u osnovi antioksidativnog dejstva α-liponske kiseline (LA), snažnog antioksidansa i jedinjenja koje stimuliše ćelijsku apsorpciju glukoze, kao i biljnih ekstrakata izolovanih iz slatkog kestena (Castanea sativa), jestivih pečuraka (Lactarius deterrimus) i prirodnih proizvoda koji sadrže β-glukan u lečenju dijabetesa. Opisani su njihova uloga u sprečavanju smrti β-ćelija pankreasa kao i blagotvorno dejstvo na komplikacije u dijabetesu.",
publisher = "Belgrade: Serbian Chemical Society, © 2013 by the Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Pozitivno dejstvo antioksidativnih jedinjenja iz biljnih ekstrakata u eksperimentalnom modelu dijabetesa, Ameliorating effects of antioxidative compounds from four plant extracts in experimental models of diabetes",
number = "3",
volume = "78",
doi = "10.2298/JSC121026136D",
pages = "365-380",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_565"
}

Dinić, S., Uskoković, A., Mihailović, M., Grdović, N., Arambašić Jovanović, J., Marković, J., Poznanović, G.,& Vidaković, M.. (2013). Pozitivno dejstvo antioksidativnih jedinjenja iz biljnih ekstrakata u eksperimentalnom modelu dijabetesa. in Journal of the Serbian Chemical Society
Belgrade: Serbian Chemical Society., 78(3), 365-380.
https://doi.org/10.2298/JSC121026136D
https://hdl.handle.net/21.15107/rcub_ibiss_565

Dinić S, Uskoković A, Mihailović M, Grdović N, Arambašić Jovanović J, Marković J, Poznanović G, Vidaković M. Pozitivno dejstvo antioksidativnih jedinjenja iz biljnih ekstrakata u eksperimentalnom modelu dijabetesa. in Journal of the Serbian Chemical Society. 2013;78(3):365-380.
doi:10.2298/JSC121026136D
https://hdl.handle.net/21.15107/rcub_ibiss_565 .

Dinić, Svetlana, Uskoković, Aleksandra, Mihailović, Mirjana, Grdović, Nevena, Arambašić Jovanović, Jelena, Marković, Jelena, Poznanović, Goran, Vidaković, Melita, "Pozitivno dejstvo antioksidativnih jedinjenja iz biljnih ekstrakata u eksperimentalnom modelu dijabetesa" in Journal of the Serbian Chemical Society, 78, no. 3 (2013):365-380,
https://doi.org/10.2298/JSC121026136D .,
https://hdl.handle.net/21.15107/rcub_ibiss_565 .

TY  - JOUR
AU  - Grdović, Nevena
AU  - Dinić, Svetlana
AU  - Arambašić Jovanović, Jelena
AU  - Mihailović, Mirjana
AU  - Uskoković, Aleksandra
AU  - Marković, Jelena
AU  - Poznanović, Goran
AU  - Vidović, Senka
AU  - Zeković, Zoran
AU  - Mujić, Aida
AU  - Mujić, Ibrahim
AU  - Vidaković, Melita
PY  - 2012
UR  - http://www.journals.cambridge.org/abstract_S0007114511006702
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3198
AB  - Pancreatic β-cell death or dysfunction mediated by oxidative stress underlies the development and progression of diabetes mellitus. In the present study, we tested extracts from the edible mushroom Lactarius deterrimus and the chestnut Castanea sativa, as well as their mixture (MIX Ld/Cs), for potential beneficial effects on streptozotocin (STZ)-induced pancreatic β-cell death. Analysis of chelating effects, reducing power and radical-scavenging assays revealed strong antioxidant effects of the C. sativa extract and MIX Ld/Cs, while the L. deterrimus extract displayed a weak to moderate effect. The antioxidative effect of the chestnut extract corresponds with the high content of phenolics and flavonoids identified by HPLC analysis. In contrast, the mushroom extract contains relatively small amounts of phenols and flavonoids. However, both extracts, and especially their combination MIX Ld/Cs, increased cell viability after the STZ treatment as a result of a significant reduction of DNA damage and improved redox status. The chestnut extract and MIX Ld/Cs significantly lowered the STZ-induced increases in superoxide dismutase and catalase activities, while the mushroom extract had no impact on the activities of these antioxidant enzymes. However, the L. deterrimus extract exhibited good NO-scavenging activity. Different mechanisms that underlie antioxidant effects of the mushroom and chestnut extracts were discussed. When combined as in the MIX Ld/Cs, the extracts exhibited diverse but synergistic actions that ultimately exerted beneficial and protective effects against STZ-induced pancreatic β-cell death.
PB  - Cambridge University Press
T2  - The British Journal of Nutrition
T1  - The protective effect of a mix of Lactarius deterrimus and Castanea sativa extracts on streptozotocin-induced oxidative stress and pancreatic β-cell death
IS  - 7
VL  - 108
DO  - 10.1017/S0007114511006702
SP  - 1163
EP  - 1176
ER  - 

@article{
author = "Grdović, Nevena and Dinić, Svetlana and Arambašić Jovanović, Jelena and Mihailović, Mirjana and Uskoković, Aleksandra and Marković, Jelena and Poznanović, Goran and Vidović, Senka and Zeković, Zoran and Mujić, Aida and Mujić, Ibrahim and Vidaković, Melita",
year = "2012",
abstract = "Pancreatic β-cell death or dysfunction mediated by oxidative stress underlies the development and progression of diabetes mellitus. In the present study, we tested extracts from the edible mushroom Lactarius deterrimus and the chestnut Castanea sativa, as well as their mixture (MIX Ld/Cs), for potential beneficial effects on streptozotocin (STZ)-induced pancreatic β-cell death. Analysis of chelating effects, reducing power and radical-scavenging assays revealed strong antioxidant effects of the C. sativa extract and MIX Ld/Cs, while the L. deterrimus extract displayed a weak to moderate effect. The antioxidative effect of the chestnut extract corresponds with the high content of phenolics and flavonoids identified by HPLC analysis. In contrast, the mushroom extract contains relatively small amounts of phenols and flavonoids. However, both extracts, and especially their combination MIX Ld/Cs, increased cell viability after the STZ treatment as a result of a significant reduction of DNA damage and improved redox status. The chestnut extract and MIX Ld/Cs significantly lowered the STZ-induced increases in superoxide dismutase and catalase activities, while the mushroom extract had no impact on the activities of these antioxidant enzymes. However, the L. deterrimus extract exhibited good NO-scavenging activity. Different mechanisms that underlie antioxidant effects of the mushroom and chestnut extracts were discussed. When combined as in the MIX Ld/Cs, the extracts exhibited diverse but synergistic actions that ultimately exerted beneficial and protective effects against STZ-induced pancreatic β-cell death.",
publisher = "Cambridge University Press",
journal = "The British Journal of Nutrition",
title = "The protective effect of a mix of Lactarius deterrimus and Castanea sativa extracts on streptozotocin-induced oxidative stress and pancreatic β-cell death",
number = "7",
volume = "108",
doi = "10.1017/S0007114511006702",
pages = "1163-1176"
}

Grdović, N., Dinić, S., Arambašić Jovanović, J., Mihailović, M., Uskoković, A., Marković, J., Poznanović, G., Vidović, S., Zeković, Z., Mujić, A., Mujić, I.,& Vidaković, M.. (2012). The protective effect of a mix of Lactarius deterrimus and Castanea sativa extracts on streptozotocin-induced oxidative stress and pancreatic β-cell death. in The British Journal of Nutrition
Cambridge University Press., 108(7), 1163-1176.
https://doi.org/10.1017/S0007114511006702

Grdović N, Dinić S, Arambašić Jovanović J, Mihailović M, Uskoković A, Marković J, Poznanović G, Vidović S, Zeković Z, Mujić A, Mujić I, Vidaković M. The protective effect of a mix of Lactarius deterrimus and Castanea sativa extracts on streptozotocin-induced oxidative stress and pancreatic β-cell death. in The British Journal of Nutrition. 2012;108(7):1163-1176.
doi:10.1017/S0007114511006702 .

Grdović, Nevena, Dinić, Svetlana, Arambašić Jovanović, Jelena, Mihailović, Mirjana, Uskoković, Aleksandra, Marković, Jelena, Poznanović, Goran, Vidović, Senka, Zeković, Zoran, Mujić, Aida, Mujić, Ibrahim, Vidaković, Melita, "The protective effect of a mix of Lactarius deterrimus and Castanea sativa extracts on streptozotocin-induced oxidative stress and pancreatic β-cell death" in The British Journal of Nutrition, 108, no. 7 (2012):1163-1176,
https://doi.org/10.1017/S0007114511006702 . .

TY  - CONF
AU  - Dinić, Svetlana
AU  - Grdović, Nevena
AU  - Uskoković, Aleksandra
AU  - Mihailović, Mirjana
AU  - Arambašić Jovanović, Jelena
AU  - Marković, Jelena
AU  - Vidaković, Melita
PY  - 2011
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6138
PB  - Braga: University of Minho
C3  - Abstract Book: Epigenetics Bench to Bedside COST Action TD O9O5; 2011 Dec 15-16; Braga, Portugal
T1  - Genetic prediction of type 1 diabetes and novel approaches for preventing pancreatic β-cell dysfunction: examination of different stages of CXCL12-mediated signalling
SP  - 21
EP  - 22
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_6138
ER  - 

@conference{
author = "Dinić, Svetlana and Grdović, Nevena and Uskoković, Aleksandra and Mihailović, Mirjana and Arambašić Jovanović, Jelena and Marković, Jelena and Vidaković, Melita",
year = "2011",
publisher = "Braga: University of Minho",
journal = "Abstract Book: Epigenetics Bench to Bedside COST Action TD O9O5; 2011 Dec 15-16; Braga, Portugal",
title = "Genetic prediction of type 1 diabetes and novel approaches for preventing pancreatic β-cell dysfunction: examination of different stages of CXCL12-mediated signalling",
pages = "21-22",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_6138"
}

Dinić, S., Grdović, N., Uskoković, A., Mihailović, M., Arambašić Jovanović, J., Marković, J.,& Vidaković, M.. (2011). Genetic prediction of type 1 diabetes and novel approaches for preventing pancreatic β-cell dysfunction: examination of different stages of CXCL12-mediated signalling. in Abstract Book: Epigenetics Bench to Bedside COST Action TD O9O5; 2011 Dec 15-16; Braga, Portugal
Braga: University of Minho., 21-22.
https://hdl.handle.net/21.15107/rcub_ibiss_6138

Dinić S, Grdović N, Uskoković A, Mihailović M, Arambašić Jovanović J, Marković J, Vidaković M. Genetic prediction of type 1 diabetes and novel approaches for preventing pancreatic β-cell dysfunction: examination of different stages of CXCL12-mediated signalling. in Abstract Book: Epigenetics Bench to Bedside COST Action TD O9O5; 2011 Dec 15-16; Braga, Portugal. 2011;:21-22.
https://hdl.handle.net/21.15107/rcub_ibiss_6138 .

Dinić, Svetlana, Grdović, Nevena, Uskoković, Aleksandra, Mihailović, Mirjana, Arambašić Jovanović, Jelena, Marković, Jelena, Vidaković, Melita, "Genetic prediction of type 1 diabetes and novel approaches for preventing pancreatic β-cell dysfunction: examination of different stages of CXCL12-mediated signalling" in Abstract Book: Epigenetics Bench to Bedside COST Action TD O9O5; 2011 Dec 15-16; Braga, Portugal (2011):21-22,
https://hdl.handle.net/21.15107/rcub_ibiss_6138 .

TY  - JOUR
AU  - Matić, Sanja
AU  - Stanić, Snežana
AU  - Bogojević, Desanka
AU  - Vidaković, Melita
AU  - Grdović, Nevena
AU  - Arambašić Jovanović, Jelena
AU  - Dinić, Svetlana
AU  - Uskoković, Aleksandra
AU  - Poznanović, Goran
AU  - Solujić, Slavica
AU  - Mladenović, Milan
AU  - Marković, Jelena
AU  - Mihailović, Mirjana
PY  - 2011
UR  - http://www.nrcresearchpress.com/doi/10.1139/y11-043#.XBD8lM0o-Uk
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3204
AB  - To examine the protective potential of the Cotinus coggygria Scop. methanol extract, Wistar rats were treated with the hepatotoxic compound pyrogallol, which possesses a potent ability to generate free radicals and induce oxidative stress. The ability of the extract to counteract the oxidative stress was examined in rats that were injected with the extract intraperitoneally (500 mg·(kg body weight)(-1)) either 2 or 12 h before the pyrogallol treatment. The extract possesses a reducing activity in vitro and an ability to chelate the ferrous ion both in vivo and in vitro. Application of the extract prior to pyrogallol treatment led to a decrease in the levels of thiobarbituric acid-reactive substances, aspartate aminotransferase, and alanine aminotransferase, increased activities of antioxidant enzymes and attenuation of DNA damage, as well as increased Akt activity and inhibition of NF-κB protein expression. Treatment with the extract 12 h prior to pyrogallol administration was more effective in suppressing pyrogallol-induced oxidative damage than the 2 h pretreatment. Extract administration promoted an increase in acute phase reactants haptoglobin and α(2)-macroglobulin that was short of a full-fledged acute phase response. Administration of the extract considerably improved the markers of oxidative stress, thus revealing a potential hepatoprotective activity. Our results suggest that Akt activation, NF-κB inhibition, and induction of the acute phase play important roles in mediating hepatic protection by the extract. The greater effectiveness of the 12 h pretreatment with extract points to the important role that preconditioning assumes in improving resistance to subsequent exposure to oxidative stress.
PB  - NRC Research Press; Canadian Science Publishing; National Research Council of Canada
PB  - © 2011 by NRC Research Press
T2  - Canadian Journal of Physiology and Pharmacology
T1  - Extract of the plant Cotinus coggygria Scop. attenuates pyrogallol-induced hepatic oxidative stress in Wistar rats
IS  - 6
VL  - 89
DO  - 10.1139/y11-043
SP  - 401
EP  - 411
ER  - 

@article{
author = "Matić, Sanja and Stanić, Snežana and Bogojević, Desanka and Vidaković, Melita and Grdović, Nevena and Arambašić Jovanović, Jelena and Dinić, Svetlana and Uskoković, Aleksandra and Poznanović, Goran and Solujić, Slavica and Mladenović, Milan and Marković, Jelena and Mihailović, Mirjana",
year = "2011",
abstract = "To examine the protective potential of the Cotinus coggygria Scop. methanol extract, Wistar rats were treated with the hepatotoxic compound pyrogallol, which possesses a potent ability to generate free radicals and induce oxidative stress. The ability of the extract to counteract the oxidative stress was examined in rats that were injected with the extract intraperitoneally (500 mg·(kg body weight)(-1)) either 2 or 12 h before the pyrogallol treatment. The extract possesses a reducing activity in vitro and an ability to chelate the ferrous ion both in vivo and in vitro. Application of the extract prior to pyrogallol treatment led to a decrease in the levels of thiobarbituric acid-reactive substances, aspartate aminotransferase, and alanine aminotransferase, increased activities of antioxidant enzymes and attenuation of DNA damage, as well as increased Akt activity and inhibition of NF-κB protein expression. Treatment with the extract 12 h prior to pyrogallol administration was more effective in suppressing pyrogallol-induced oxidative damage than the 2 h pretreatment. Extract administration promoted an increase in acute phase reactants haptoglobin and α(2)-macroglobulin that was short of a full-fledged acute phase response. Administration of the extract considerably improved the markers of oxidative stress, thus revealing a potential hepatoprotective activity. Our results suggest that Akt activation, NF-κB inhibition, and induction of the acute phase play important roles in mediating hepatic protection by the extract. The greater effectiveness of the 12 h pretreatment with extract points to the important role that preconditioning assumes in improving resistance to subsequent exposure to oxidative stress.",
publisher = "NRC Research Press; Canadian Science Publishing; National Research Council of Canada, © 2011 by NRC Research Press",
journal = "Canadian Journal of Physiology and Pharmacology",
title = "Extract of the plant Cotinus coggygria Scop. attenuates pyrogallol-induced hepatic oxidative stress in Wistar rats",
number = "6",
volume = "89",
doi = "10.1139/y11-043",
pages = "401-411"
}

Matić, S., Stanić, S., Bogojević, D., Vidaković, M., Grdović, N., Arambašić Jovanović, J., Dinić, S., Uskoković, A., Poznanović, G., Solujić, S., Mladenović, M., Marković, J.,& Mihailović, M.. (2011). Extract of the plant Cotinus coggygria Scop. attenuates pyrogallol-induced hepatic oxidative stress in Wistar rats. in Canadian Journal of Physiology and Pharmacology
NRC Research Press; Canadian Science Publishing; National Research Council of Canada., 89(6), 401-411.
https://doi.org/10.1139/y11-043

Matić S, Stanić S, Bogojević D, Vidaković M, Grdović N, Arambašić Jovanović J, Dinić S, Uskoković A, Poznanović G, Solujić S, Mladenović M, Marković J, Mihailović M. Extract of the plant Cotinus coggygria Scop. attenuates pyrogallol-induced hepatic oxidative stress in Wistar rats. in Canadian Journal of Physiology and Pharmacology. 2011;89(6):401-411.
doi:10.1139/y11-043 .

Matić, Sanja, Stanić, Snežana, Bogojević, Desanka, Vidaković, Melita, Grdović, Nevena, Arambašić Jovanović, Jelena, Dinić, Svetlana, Uskoković, Aleksandra, Poznanović, Goran, Solujić, Slavica, Mladenović, Milan, Marković, Jelena, Mihailović, Mirjana, "Extract of the plant Cotinus coggygria Scop. attenuates pyrogallol-induced hepatic oxidative stress in Wistar rats" in Canadian Journal of Physiology and Pharmacology, 89, no. 6 (2011):401-411,
https://doi.org/10.1139/y11-043 . .