TY  - CONF
AU  - Pergal, Marija V.
AU  - Brkljačić, Jelena
AU  - Vasiljević Radović, Dana
AU  - Pergal, Miodrag M.
AU  - Pešić, Ivan
AU  - Dević, Gordana
AU  - Tovilović-Kovačević, Gordana
PY  - 2023
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6192
AB  - Polyurethane (PU) nanocomposite materials, offer very desirable advantages over pure PU materials,as the nanocomposites have enhanced thermal, surface, mechanical and biological properties. The main goal of this study was to develop a new kind of novel nanocomposites consisting of crosslinked PUs (based on poly(dimetylsiloxane) and hyperbranched polyester) and ferrite nanoparticles (based on copper and zinc) for possible application as coatings on biomedical devices and implants. A series of PU/ferrite nanocomposites was prepared by in situ polymerization in solution. Characterization of prepared nanocomposites nanocomposites was conducted by Fourier transform infrared spectroscopy (FTIR) and atomic force microscopy (AFM). Copper and zinc releases were investigated by microwave plasma atomic emission spectrometry (MP-AES). Characteristics of the prepared nanocomposites when in contact with a biological environment were examined through testing their biocompatibility, and adhesion of fibroblast cells. The presence of the nanoferrite nanoparticles influenced on surface and biological properties of PU nanocomposites. The prepared PU nanocomposites with noncytotoxic chemistry could be used as promising materials for vascular implants development.
PB  - Belgrade: Serbian Ceramic Society
C3  - Program and the Book of Abstracts: Serbian Ceramic Society Conference Advanced Ceramics and Application 11: New Frontiers in Multifunctional Material Science and Processing; 2023 Sep 18-20; Belgrade, Serbia
T1  - Characterization of polyurethane/ferrite nanocomposites
SP  - 65
EP  - 65
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_6192
ER  - 

@conference{
author = "Pergal, Marija V. and Brkljačić, Jelena and Vasiljević Radović, Dana and Pergal, Miodrag M. and Pešić, Ivan and Dević, Gordana and Tovilović-Kovačević, Gordana",
year = "2023",
abstract = "Polyurethane (PU) nanocomposite materials, offer very desirable advantages over pure PU materials,as the nanocomposites have enhanced thermal, surface, mechanical and biological properties. The main goal of this study was to develop a new kind of novel nanocomposites consisting of crosslinked PUs (based on poly(dimetylsiloxane) and hyperbranched polyester) and ferrite nanoparticles (based on copper and zinc) for possible application as coatings on biomedical devices and implants. A series of PU/ferrite nanocomposites was prepared by in situ polymerization in solution. Characterization of prepared nanocomposites nanocomposites was conducted by Fourier transform infrared spectroscopy (FTIR) and atomic force microscopy (AFM). Copper and zinc releases were investigated by microwave plasma atomic emission spectrometry (MP-AES). Characteristics of the prepared nanocomposites when in contact with a biological environment were examined through testing their biocompatibility, and adhesion of fibroblast cells. The presence of the nanoferrite nanoparticles influenced on surface and biological properties of PU nanocomposites. The prepared PU nanocomposites with noncytotoxic chemistry could be used as promising materials for vascular implants development.",
publisher = "Belgrade: Serbian Ceramic Society",
journal = "Program and the Book of Abstracts: Serbian Ceramic Society Conference Advanced Ceramics and Application 11: New Frontiers in Multifunctional Material Science and Processing; 2023 Sep 18-20; Belgrade, Serbia",
title = "Characterization of polyurethane/ferrite nanocomposites",
pages = "65-65",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_6192"
}

Pergal, M. V., Brkljačić, J., Vasiljević Radović, D., Pergal, M. M., Pešić, I., Dević, G.,& Tovilović-Kovačević, G.. (2023). Characterization of polyurethane/ferrite nanocomposites. in Program and the Book of Abstracts: Serbian Ceramic Society Conference Advanced Ceramics and Application 11: New Frontiers in Multifunctional Material Science and Processing; 2023 Sep 18-20; Belgrade, Serbia
Belgrade: Serbian Ceramic Society., 65-65.
https://hdl.handle.net/21.15107/rcub_ibiss_6192

Pergal MV, Brkljačić J, Vasiljević Radović D, Pergal MM, Pešić I, Dević G, Tovilović-Kovačević G. Characterization of polyurethane/ferrite nanocomposites. in Program and the Book of Abstracts: Serbian Ceramic Society Conference Advanced Ceramics and Application 11: New Frontiers in Multifunctional Material Science and Processing; 2023 Sep 18-20; Belgrade, Serbia. 2023;:65-65.
https://hdl.handle.net/21.15107/rcub_ibiss_6192 .

Pergal, Marija V., Brkljačić, Jelena, Vasiljević Radović, Dana, Pergal, Miodrag M., Pešić, Ivan, Dević, Gordana, Tovilović-Kovačević, Gordana, "Characterization of polyurethane/ferrite nanocomposites" in Program and the Book of Abstracts: Serbian Ceramic Society Conference Advanced Ceramics and Application 11: New Frontiers in Multifunctional Material Science and Processing; 2023 Sep 18-20; Belgrade, Serbia (2023):65-65,
https://hdl.handle.net/21.15107/rcub_ibiss_6192 .

TY  - JOUR
AU  - Pergal, Marija V.
AU  - Brkljačić, Jelena
AU  - Tovilović-Kovačević, Gordana
AU  - Špírkova, Milena
AU  - Kodranov, Igor D.
AU  - Manojlović, Dragan D.
AU  - Ostojić, Sanja
AU  - Knežević, Nikola Ž.
PY  - 2021
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4161
AB  - Novel polyurethane nanocomposite (PUN) materials containing different surface-functionalized mesoporous silica nanoparticles (MSNs) were prepared by in situ polymerization methodology. Polyurethane network was formed from poly (dimethylsiloxane)-based macrodiol (PDMS), 4, 4′ -methylenediphenyldiisocyanate (MDI), and hyperbranched polyester of the second pseudo-generation (BH-20; used as crosslinking agent). PU and PU/MSN nanocomposites contained equal ratios of soft PDMS and hard MDI-BH-20 segments. Non-functionalized and surface-functionalized (with 3-(trihydroxysilyl) propyl methylphosphonate (FOMSN) and 2-[methoxy (polyethyleneoxy) 6-9propyl] trimethoxysilane (PEGMSN)) MSNs were used as the nanofillers at a concentration of 1 wt%. Prepared materials were characterized by Fourier transform infrared (FTIR) spectroscopy, atomic force microscopy (AFM), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), dynamic mechanical thermal analyses (DMTA), nanoindentation, equilibrium swelling and water absorption measurements. Characteristics of the prepared PUNs when in contact with a biological environment were assessed through testing their biocompatibility, protein adsorption and adhesion of endothelial cells. The favourable influence of MSNs on the physico-chemical and biological characteristics of these novel PUN materials was identified, which evidences their vast applicability potential as coatings for medical devices and implants.
PB  - Elsevier
T2  - Progress in Organic Coatings
T1  - Effect of mesoporous silica nanoparticles on the properties of polyurethane network composites
VL  - 151
DO  - 10.1016/j.porgcoat.2020.106049
SP  - 106049
ER  - 

@article{
author = "Pergal, Marija V. and Brkljačić, Jelena and Tovilović-Kovačević, Gordana and Špírkova, Milena and Kodranov, Igor D. and Manojlović, Dragan D. and Ostojić, Sanja and Knežević, Nikola Ž.",
year = "2021",
abstract = "Novel polyurethane nanocomposite (PUN) materials containing different surface-functionalized mesoporous silica nanoparticles (MSNs) were prepared by in situ polymerization methodology. Polyurethane network was formed from poly (dimethylsiloxane)-based macrodiol (PDMS), 4, 4′ -methylenediphenyldiisocyanate (MDI), and hyperbranched polyester of the second pseudo-generation (BH-20; used as crosslinking agent). PU and PU/MSN nanocomposites contained equal ratios of soft PDMS and hard MDI-BH-20 segments. Non-functionalized and surface-functionalized (with 3-(trihydroxysilyl) propyl methylphosphonate (FOMSN) and 2-[methoxy (polyethyleneoxy) 6-9propyl] trimethoxysilane (PEGMSN)) MSNs were used as the nanofillers at a concentration of 1 wt%. Prepared materials were characterized by Fourier transform infrared (FTIR) spectroscopy, atomic force microscopy (AFM), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), dynamic mechanical thermal analyses (DMTA), nanoindentation, equilibrium swelling and water absorption measurements. Characteristics of the prepared PUNs when in contact with a biological environment were assessed through testing their biocompatibility, protein adsorption and adhesion of endothelial cells. The favourable influence of MSNs on the physico-chemical and biological characteristics of these novel PUN materials was identified, which evidences their vast applicability potential as coatings for medical devices and implants.",
publisher = "Elsevier",
journal = "Progress in Organic Coatings",
title = "Effect of mesoporous silica nanoparticles on the properties of polyurethane network composites",
volume = "151",
doi = "10.1016/j.porgcoat.2020.106049",
pages = "106049"
}

Pergal, M. V., Brkljačić, J., Tovilović-Kovačević, G., Špírkova, M., Kodranov, I. D., Manojlović, D. D., Ostojić, S.,& Knežević, N. Ž.. (2021). Effect of mesoporous silica nanoparticles on the properties of polyurethane network composites. in Progress in Organic Coatings
Elsevier., 151, 106049.
https://doi.org/10.1016/j.porgcoat.2020.106049

Pergal MV, Brkljačić J, Tovilović-Kovačević G, Špírkova M, Kodranov ID, Manojlović DD, Ostojić S, Knežević NŽ. Effect of mesoporous silica nanoparticles on the properties of polyurethane network composites. in Progress in Organic Coatings. 2021;151:106049.
doi:10.1016/j.porgcoat.2020.106049 .

Pergal, Marija V., Brkljačić, Jelena, Tovilović-Kovačević, Gordana, Špírkova, Milena, Kodranov, Igor D., Manojlović, Dragan D., Ostojić, Sanja, Knežević, Nikola Ž., "Effect of mesoporous silica nanoparticles on the properties of polyurethane network composites" in Progress in Organic Coatings, 151 (2021):106049,
https://doi.org/10.1016/j.porgcoat.2020.106049 . .

TY  - JOUR
AU  - Pergal, Marija V.
AU  - Kodranov, Igor D.
AU  - Pergal, Miodrag M.
AU  - Gašić, Uroš
AU  - Stanković, Dalibor M.
AU  - Petković, Branka B.
AU  - Manojlović, Dragan D.
PY  - 2020
UR  - https://doi.org/10.1007/s11270-020-04800-x
UR  - https://radar.ibiss.bg.ac.rs/123456789/3852
AB  - The aim of this study was to investigate, analyze, and compare applied techniques suitable for achieving efficient removal of organophosphorus pesticides (OPPs) (malathion and fenitrothion) from aqueous solutions and analyze the degradation products and processes. Pesticide degradation efficiency (%) was monitored by high-performance liquid chromatography (HPLC) equipped with a photodiode array detector (DAD), while mineralization degree was determined by total organic carbon analysis (TOC). Daphnia magna was used for screening the environmental safety aspects of the degradation methods, i.e., for assessing the toxicity of solutions obtained after degradation. Additionally, a surface river water was utilized to examine the likely influence of organic matter on the pesticides’ degradation. Pesticide degradation products were identified using gas chromatography with a triple quadrupole mass detector (GC-MS/MS) as well as ultrahigh-performance liquid chromatography coupled with a linear ion trap, Orbitrap mass spectrometer (UHPLC-LTQ Orbitrap MS), and a simple pesticide degradation mechanism is proposed. Removal of pesticides from water using chlorine dioxide was successful, resulting in high degradation efficiency (98% for malathion and 81% for fenitrothion). Partial mineralization was achieved, and Daphnia magna mortality decreased in the waters containing degradation products (compared with the parent pesticides), indicating that the solutions formed were less toxic than the parent pesticides. Lower degradation rates (80% for malathion and 72% for fenitrothion) in Sava River water were measured, indicating the influence of the organic matter contained in this naturally occurring surface water. The results prove that chlorine dioxide could be used as an agent for successful removal of these OPPs from water.
PB  - Springer
T2  - Water, Air, and Soil Pollution
T1  - Degradation Products, Mineralization, and Toxicity Assessment of Pesticides Malathion and Fenitrothion
IS  - 8
VL  - 231
DO  - 10.1007/s11270-020-04800-x
SP  - 433
ER  - 

@article{
author = "Pergal, Marija V. and Kodranov, Igor D. and Pergal, Miodrag M. and Gašić, Uroš and Stanković, Dalibor M. and Petković, Branka B. and Manojlović, Dragan D.",
year = "2020",
abstract = "The aim of this study was to investigate, analyze, and compare applied techniques suitable for achieving efficient removal of organophosphorus pesticides (OPPs) (malathion and fenitrothion) from aqueous solutions and analyze the degradation products and processes. Pesticide degradation efficiency (%) was monitored by high-performance liquid chromatography (HPLC) equipped with a photodiode array detector (DAD), while mineralization degree was determined by total organic carbon analysis (TOC). Daphnia magna was used for screening the environmental safety aspects of the degradation methods, i.e., for assessing the toxicity of solutions obtained after degradation. Additionally, a surface river water was utilized to examine the likely influence of organic matter on the pesticides’ degradation. Pesticide degradation products were identified using gas chromatography with a triple quadrupole mass detector (GC-MS/MS) as well as ultrahigh-performance liquid chromatography coupled with a linear ion trap, Orbitrap mass spectrometer (UHPLC-LTQ Orbitrap MS), and a simple pesticide degradation mechanism is proposed. Removal of pesticides from water using chlorine dioxide was successful, resulting in high degradation efficiency (98% for malathion and 81% for fenitrothion). Partial mineralization was achieved, and Daphnia magna mortality decreased in the waters containing degradation products (compared with the parent pesticides), indicating that the solutions formed were less toxic than the parent pesticides. Lower degradation rates (80% for malathion and 72% for fenitrothion) in Sava River water were measured, indicating the influence of the organic matter contained in this naturally occurring surface water. The results prove that chlorine dioxide could be used as an agent for successful removal of these OPPs from water.",
publisher = "Springer",
journal = "Water, Air, and Soil Pollution",
title = "Degradation Products, Mineralization, and Toxicity Assessment of Pesticides Malathion and Fenitrothion",
number = "8",
volume = "231",
doi = "10.1007/s11270-020-04800-x",
pages = "433"
}

Pergal, M. V., Kodranov, I. D., Pergal, M. M., Gašić, U., Stanković, D. M., Petković, B. B.,& Manojlović, D. D.. (2020). Degradation Products, Mineralization, and Toxicity Assessment of Pesticides Malathion and Fenitrothion. in Water, Air, and Soil Pollution
Springer., 231(8), 433.
https://doi.org/10.1007/s11270-020-04800-x

Pergal MV, Kodranov ID, Pergal MM, Gašić U, Stanković DM, Petković BB, Manojlović DD. Degradation Products, Mineralization, and Toxicity Assessment of Pesticides Malathion and Fenitrothion. in Water, Air, and Soil Pollution. 2020;231(8):433.
doi:10.1007/s11270-020-04800-x .

Pergal, Marija V., Kodranov, Igor D., Pergal, Miodrag M., Gašić, Uroš, Stanković, Dalibor M., Petković, Branka B., Manojlović, Dragan D., "Degradation Products, Mineralization, and Toxicity Assessment of Pesticides Malathion and Fenitrothion" in Water, Air, and Soil Pollution, 231, no. 8 (2020):433,
https://doi.org/10.1007/s11270-020-04800-x . .

TY  - CHAP
AU  - Pergal, Marija V.
AU  - Balaban, Milica
AU  - Brkljačić, Jelena
AU  - Tovilović-Kovačević, Gordana
PY  - 2016
UR  - https://www.novapublishers.com/catalog/product_info.php?products_id=56512
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2872
AB  - This chapter reviews the research and the most relevant advances in the investigation of thermoplastic polyurethane elastomers, TPU, and provides a comprehensive source of information on their synthesis, structure, properties and applications. TPUs are multiblock copolymers built up from so-called short, rigid hard segments and long, flexible soft segments. The thermodynamic incompatibility of the hard and soft segments at low temperatures results in phase separation and, consequently, in the formation of a domain structure. Due to their twophase microstructure, TPUs exhibit a combination of unusual thermoplastic and elastomeric behavior. The properties of TPUs depend on many variables, such as the chemical structure of the segments, the ratio of the hard/soft segment content, the molecular weight of the soft segments, the degree of crystallinity of the hard segments, and, in some cases, crystallization of the soft segments and the ability to form discrete crystalline and rubbery or viscous microdomains. The versatility of this class of materials promises that novel TPUs will play a key role in many future biomedical applications. Knowledge of the structure and properties of TPUs and their influence on the biocompatibility of TPUs is of great practical importance; therefore, this chapter also reviews biocompatibility assessment of different TPUs using recent studies presented in the literature. The latest developments in design of TPU nanocomposites, as well as in future trends for TPUs are also presented.
PB  - Nova Science Publishers, Inc., New York
T2  - Polyurethanes: Properties, Uses and Prospects
T1  - Synthesis, characterization and applications of thermoplastic polyurethane elastomers
SP  - 17
EP  - 90
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_2872
ER  - 

@inbook{
editor = "Hope, Frederick L.",
author = "Pergal, Marija V. and Balaban, Milica and Brkljačić, Jelena and Tovilović-Kovačević, Gordana",
year = "2016",
abstract = "This chapter reviews the research and the most relevant advances in the investigation of thermoplastic polyurethane elastomers, TPU, and provides a comprehensive source of information on their synthesis, structure, properties and applications. TPUs are multiblock copolymers built up from so-called short, rigid hard segments and long, flexible soft segments. The thermodynamic incompatibility of the hard and soft segments at low temperatures results in phase separation and, consequently, in the formation of a domain structure. Due to their twophase microstructure, TPUs exhibit a combination of unusual thermoplastic and elastomeric behavior. The properties of TPUs depend on many variables, such as the chemical structure of the segments, the ratio of the hard/soft segment content, the molecular weight of the soft segments, the degree of crystallinity of the hard segments, and, in some cases, crystallization of the soft segments and the ability to form discrete crystalline and rubbery or viscous microdomains. The versatility of this class of materials promises that novel TPUs will play a key role in many future biomedical applications. Knowledge of the structure and properties of TPUs and their influence on the biocompatibility of TPUs is of great practical importance; therefore, this chapter also reviews biocompatibility assessment of different TPUs using recent studies presented in the literature. The latest developments in design of TPU nanocomposites, as well as in future trends for TPUs are also presented.",
publisher = "Nova Science Publishers, Inc., New York",
journal = "Polyurethanes: Properties, Uses and Prospects",
booktitle = "Synthesis, characterization and applications of thermoplastic polyurethane elastomers",
pages = "17-90",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_2872"
}

Hope, F. L., Pergal, M. V., Balaban, M., Brkljačić, J.,& Tovilović-Kovačević, G.. (2016). Synthesis, characterization and applications of thermoplastic polyurethane elastomers. in Polyurethanes: Properties, Uses and Prospects
Nova Science Publishers, Inc., New York., 17-90.
https://hdl.handle.net/21.15107/rcub_ibiss_2872

Hope FL, Pergal MV, Balaban M, Brkljačić J, Tovilović-Kovačević G. Synthesis, characterization and applications of thermoplastic polyurethane elastomers. in Polyurethanes: Properties, Uses and Prospects. 2016;:17-90.
https://hdl.handle.net/21.15107/rcub_ibiss_2872 .

Hope, Frederick L., Pergal, Marija V., Balaban, Milica, Brkljačić, Jelena, Tovilović-Kovačević, Gordana, "Synthesis, characterization and applications of thermoplastic polyurethane elastomers" in Polyurethanes: Properties, Uses and Prospects (2016):17-90,
https://hdl.handle.net/21.15107/rcub_ibiss_2872 .

TY  - JOUR
AU  - Stefanovic, Ivan S.
AU  - Djonlagic, Jasna
AU  - Tovilović-Kovačević, Gordana
AU  - Brkljačić, Jelena
AU  - Antic, Vesna V.
AU  - Ostojic, Sanja
AU  - Pergal, Marija V.
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1983
AB  - Polyurethane copolymers based on ,-dihydroxypropyl
   poly(dimethylsiloxane) (PDMS) with a range of soft segment contents were
   prepared by two-stage polymerization, and their microstructures,
   thermal, thermomechanical, and surface properties, as well as in vitro
   hemo- and cytocompatibility were evaluated. All utilized
   characterization methods confirmed the existence of moderately
   microphase separated structures with the appearance of some microphase
   mixing between segments as the PDMS (i.e., soft segment) content
   increased. Copolymers showed higher crystallinity, storage moduli,
   surface roughness, and surface free energy, but less hydrophobicity with
   decreasing PDMS content. Biocompatibility of copolymers was evaluated
   using an endothelial EA.hy926 cell line by direct contact, an extraction
   method and after pretreatment of copolymers with multicomponent protein
   mixture, as well as by a competitive protein adsorption assay.
   Copolymers showed no toxic effect to endothelial cells and all
   copolymers, except that with the lowest PDMS content, exhibited
   resistance to endothelial cell adhesion, suggesting their unsuitability
   for long-term biomedical devices which particularly require
   re-endothelialization. All copolymers exhibited excellent resistance to
   fibrinogen adsorption and adsorbed more albumin than fibrinogen in the
   competitive adsorption assay, suggesting their good hemocompatibility.
   The noncytotoxic chemistry of these synthesized materials, combined with
   their nonadherent properties which are inhospitable to cell attachment
   and growth, underlie the need for further investigations to clarify
   their potential for use in short-term biomedical devices. (c) 2014 Wiley
   Periodicals, Inc. J Biomed Mater Res Part A: 103A: 1459-1475, 2015.
T2  - Journal of Biomedical Materials Research Part A
T1  - Poly(urethane-dimethylsiloxane) copolymers displaying a range of soft
 segment contents, noncytotoxic chemistry, and nonadherent properties
 toward endothelial cells
IS  - 4
VL  - 103
DO  - 10.1002/jbm.a.35285
SP  - 1459
EP  - 1475
ER  - 

@article{
author = "Stefanovic, Ivan S. and Djonlagic, Jasna and Tovilović-Kovačević, Gordana and Brkljačić, Jelena and Antic, Vesna V. and Ostojic, Sanja and Pergal, Marija V.",
year = "2015",
abstract = "Polyurethane copolymers based on ,-dihydroxypropyl
   poly(dimethylsiloxane) (PDMS) with a range of soft segment contents were
   prepared by two-stage polymerization, and their microstructures,
   thermal, thermomechanical, and surface properties, as well as in vitro
   hemo- and cytocompatibility were evaluated. All utilized
   characterization methods confirmed the existence of moderately
   microphase separated structures with the appearance of some microphase
   mixing between segments as the PDMS (i.e., soft segment) content
   increased. Copolymers showed higher crystallinity, storage moduli,
   surface roughness, and surface free energy, but less hydrophobicity with
   decreasing PDMS content. Biocompatibility of copolymers was evaluated
   using an endothelial EA.hy926 cell line by direct contact, an extraction
   method and after pretreatment of copolymers with multicomponent protein
   mixture, as well as by a competitive protein adsorption assay.
   Copolymers showed no toxic effect to endothelial cells and all
   copolymers, except that with the lowest PDMS content, exhibited
   resistance to endothelial cell adhesion, suggesting their unsuitability
   for long-term biomedical devices which particularly require
   re-endothelialization. All copolymers exhibited excellent resistance to
   fibrinogen adsorption and adsorbed more albumin than fibrinogen in the
   competitive adsorption assay, suggesting their good hemocompatibility.
   The noncytotoxic chemistry of these synthesized materials, combined with
   their nonadherent properties which are inhospitable to cell attachment
   and growth, underlie the need for further investigations to clarify
   their potential for use in short-term biomedical devices. (c) 2014 Wiley
   Periodicals, Inc. J Biomed Mater Res Part A: 103A: 1459-1475, 2015.",
journal = "Journal of Biomedical Materials Research Part A",
title = "Poly(urethane-dimethylsiloxane) copolymers displaying a range of soft
 segment contents, noncytotoxic chemistry, and nonadherent properties
 toward endothelial cells",
number = "4",
volume = "103",
doi = "10.1002/jbm.a.35285",
pages = "1459-1475"
}

Stefanovic, I. S., Djonlagic, J., Tovilović-Kovačević, G., Brkljačić, J., Antic, V. V., Ostojic, S.,& Pergal, M. V.. (2015). Poly(urethane-dimethylsiloxane) copolymers displaying a range of soft
 segment contents, noncytotoxic chemistry, and nonadherent properties
 toward endothelial cells. in Journal of Biomedical Materials Research Part A, 103(4), 1459-1475.
https://doi.org/10.1002/jbm.a.35285

Stefanovic IS, Djonlagic J, Tovilović-Kovačević G, Brkljačić J, Antic VV, Ostojic S, Pergal MV. Poly(urethane-dimethylsiloxane) copolymers displaying a range of soft
 segment contents, noncytotoxic chemistry, and nonadherent properties
 toward endothelial cells. in Journal of Biomedical Materials Research Part A. 2015;103(4):1459-1475.
doi:10.1002/jbm.a.35285 .

Stefanovic, Ivan S., Djonlagic, Jasna, Tovilović-Kovačević, Gordana, Brkljačić, Jelena, Antic, Vesna V., Ostojic, Sanja, Pergal, Marija V., "Poly(urethane-dimethylsiloxane) copolymers displaying a range of soft
 segment contents, noncytotoxic chemistry, and nonadherent properties
 toward endothelial cells" in Journal of Biomedical Materials Research Part A, 103, no. 4 (2015):1459-1475,
https://doi.org/10.1002/jbm.a.35285 . .

TY  - JOUR
AU  - Pergal, Marija V.
AU  - Brkljačić, Jelena
AU  - Tovilović-Kovačević, Gordana
AU  - Ostojic, Sanja
AU  - Godevac, Dejan
AU  - Vasiljevic-Radovic, Dana
AU  - Djonlagic, Jasna
PY  - 2014
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2135
AB  - Properties and biocompatibility of a series of thermoplastic
   poly(urethane-siloxane)s (TPUSs) based on alpha,omega-dihydroxy ethoxy
   propyl poly(dimethylsiloxane) (PDMS) for potential biomedical
   application were studied. Thin films of TPUSs with a different PDMS soft
   segment content were characterized by H-1 NMR, quantitative C-13 NMR,
   Fourier transform infrared spectroscopy (FTIR), atomic force microscopy
   (AFM), differential scanning calorimetry (DSC), dynamic mechanical
   analysis (DMA), contact angle, and water absorption measurements.
   Different techniques (FTIR, AFM, and DMA) showed that decrease of PDMS
   content promotes microphase separation in TPUSs. Samples with a higher
   PDMS content have more hydrophobic surface and better waterproof
   performances, but lower degree of crystallinity. Biocompatibility of
   TPUSs was examined after attachment of endothelial cells to the
   untreated copolymer surface or surface pretreated with multicomponent
   protein mixture, and by using competitive protein adsorption assay.
   TPUSs did not exhibit any cytotoxicity toward endothelial cells, as
   measured by lactate dehydrogenase and
   3-{[}4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide assays.
   The untreated and proteins preadsorbed TPUS samples favored endothelial
   cells adhesion and growth, indicating good biocompatibility. All TPUSs
   adsorbed more albumin than fibrinogen in competitive protein adsorption
   experiment, which is feature regarded as beneficial for
   biocompatibility. The results indicate that TPUSs have good surface,
   thermo-mechanical, and biocompatible properties, which can be tailored
   for biomedical application requirements by adequate selection of the
   soft/hard segments ratio of the copolymers. (C) 2013 Wiley Periodicals,
   Inc.
T2  - Journal of Biomedical Materials Research Part A
T1  - Structure and properties of thermoplastic polyurethanes based on
 poly(dimethylsiloxane): Assessment of biocompatibility
IS  - 11
VL  - 102
DO  - 10.1002/jbm.a.35071
SP  - 3951
EP  - 3964
ER  - 

@article{
author = "Pergal, Marija V. and Brkljačić, Jelena and Tovilović-Kovačević, Gordana and Ostojic, Sanja and Godevac, Dejan and Vasiljevic-Radovic, Dana and Djonlagic, Jasna",
year = "2014",
abstract = "Properties and biocompatibility of a series of thermoplastic
   poly(urethane-siloxane)s (TPUSs) based on alpha,omega-dihydroxy ethoxy
   propyl poly(dimethylsiloxane) (PDMS) for potential biomedical
   application were studied. Thin films of TPUSs with a different PDMS soft
   segment content were characterized by H-1 NMR, quantitative C-13 NMR,
   Fourier transform infrared spectroscopy (FTIR), atomic force microscopy
   (AFM), differential scanning calorimetry (DSC), dynamic mechanical
   analysis (DMA), contact angle, and water absorption measurements.
   Different techniques (FTIR, AFM, and DMA) showed that decrease of PDMS
   content promotes microphase separation in TPUSs. Samples with a higher
   PDMS content have more hydrophobic surface and better waterproof
   performances, but lower degree of crystallinity. Biocompatibility of
   TPUSs was examined after attachment of endothelial cells to the
   untreated copolymer surface or surface pretreated with multicomponent
   protein mixture, and by using competitive protein adsorption assay.
   TPUSs did not exhibit any cytotoxicity toward endothelial cells, as
   measured by lactate dehydrogenase and
   3-{[}4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide assays.
   The untreated and proteins preadsorbed TPUS samples favored endothelial
   cells adhesion and growth, indicating good biocompatibility. All TPUSs
   adsorbed more albumin than fibrinogen in competitive protein adsorption
   experiment, which is feature regarded as beneficial for
   biocompatibility. The results indicate that TPUSs have good surface,
   thermo-mechanical, and biocompatible properties, which can be tailored
   for biomedical application requirements by adequate selection of the
   soft/hard segments ratio of the copolymers. (C) 2013 Wiley Periodicals,
   Inc.",
journal = "Journal of Biomedical Materials Research Part A",
title = "Structure and properties of thermoplastic polyurethanes based on
 poly(dimethylsiloxane): Assessment of biocompatibility",
number = "11",
volume = "102",
doi = "10.1002/jbm.a.35071",
pages = "3951-3964"
}

Pergal, M. V., Brkljačić, J., Tovilović-Kovačević, G., Ostojic, S., Godevac, D., Vasiljevic-Radovic, D.,& Djonlagic, J.. (2014). Structure and properties of thermoplastic polyurethanes based on
 poly(dimethylsiloxane): Assessment of biocompatibility. in Journal of Biomedical Materials Research Part A, 102(11), 3951-3964.
https://doi.org/10.1002/jbm.a.35071

Pergal MV, Brkljačić J, Tovilović-Kovačević G, Ostojic S, Godevac D, Vasiljevic-Radovic D, Djonlagic J. Structure and properties of thermoplastic polyurethanes based on
 poly(dimethylsiloxane): Assessment of biocompatibility. in Journal of Biomedical Materials Research Part A. 2014;102(11):3951-3964.
doi:10.1002/jbm.a.35071 .

Pergal, Marija V., Brkljačić, Jelena, Tovilović-Kovačević, Gordana, Ostojic, Sanja, Godevac, Dejan, Vasiljevic-Radovic, Dana, Djonlagic, Jasna, "Structure and properties of thermoplastic polyurethanes based on
 poly(dimethylsiloxane): Assessment of biocompatibility" in Journal of Biomedical Materials Research Part A, 102, no. 11 (2014):3951-3964,
https://doi.org/10.1002/jbm.a.35071 . .

TY  - JOUR
AU  - Pergal, Marija V.
AU  - Brkljačić, Jelena
AU  - Tovilović-Kovačević, Gordana
AU  - Jovančić, Petar
AU  - Pezo, Lato
AU  - Vasiljević-Radović, Dana
AU  - Djonlagić, Jasna
PY  - 2014
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2125
AB  - Segmented polyurethanes based on poly(dimethylsiloxane), currently used
   for biomedical applications, have sub-optimal biocompatibility which
   reduces their efficacy. Improving the endothelial cell attachment and
   blood-contacting properties of PDMS-based copolymers would substantially
   improve their clinical applications. We have studied the surface
   properties and in vitro biocompatibility of two series of segmented
   poly(urethane-dimethylsiloxane)s (SPU-PDMS) based on hydroxypropyl-and
   hydroxyethoxypropyl-terminated PDMS with potential applications in
   blood-contacting medical devices. SPU-PDMS copolymers were characterized
   by contact angle measurements, surface free energy determination
   (calculated using the van Oss-Chaudhury-Good and Owens-Wendt methods),
   and atomic force microscopy. The biocompatibility of copolymers was
   evaluated using an endothelial EA.hy926 cell line by direct contact
   assay, before and after pre-treatment of copolymers with multicomponent
   protein mixture, as well as by a competitive blood-protein adsorption
   assay. The obtained results suggested good blood compatibility of
   synthesized copolymers. All copolymers exhibited good resistance to
   fibrinogen adsorption and all favored albumin adsorption. Copolymers
   based on hydroxyethoxypropyl-PDMS had lower hydrophobicity, higher
   surface free energy and better microphase separation in comparison with
   hydroxypropyl-PDMS-based copolymers, which promoted better endothelial
   cell attachment and growth on the surface of these polymers as compared
   to hydroxypropyl-PDMS-based copolymers. The results showed that SPU-PDMS
   copolymers display good surface properties, depending on the type of
   soft PDMS segments, which can be tailored for biomedical application
   requirements such as biomedical devices for short-and long-term uses.
T2  - Hemijska Industrija
T1  - Surface characterization, hemo-and cytocompatibility of segmented
 poly(dimethylsiloxane)-based polyurethanes
IS  - 6
VL  - 68
DO  - 10.2298/HEMIND141103082P
SP  - 731
EP  - 741
ER  - 

@article{
author = "Pergal, Marija V. and Brkljačić, Jelena and Tovilović-Kovačević, Gordana and Jovančić, Petar and Pezo, Lato and Vasiljević-Radović, Dana and Djonlagić, Jasna",
year = "2014",
abstract = "Segmented polyurethanes based on poly(dimethylsiloxane), currently used
   for biomedical applications, have sub-optimal biocompatibility which
   reduces their efficacy. Improving the endothelial cell attachment and
   blood-contacting properties of PDMS-based copolymers would substantially
   improve their clinical applications. We have studied the surface
   properties and in vitro biocompatibility of two series of segmented
   poly(urethane-dimethylsiloxane)s (SPU-PDMS) based on hydroxypropyl-and
   hydroxyethoxypropyl-terminated PDMS with potential applications in
   blood-contacting medical devices. SPU-PDMS copolymers were characterized
   by contact angle measurements, surface free energy determination
   (calculated using the van Oss-Chaudhury-Good and Owens-Wendt methods),
   and atomic force microscopy. The biocompatibility of copolymers was
   evaluated using an endothelial EA.hy926 cell line by direct contact
   assay, before and after pre-treatment of copolymers with multicomponent
   protein mixture, as well as by a competitive blood-protein adsorption
   assay. The obtained results suggested good blood compatibility of
   synthesized copolymers. All copolymers exhibited good resistance to
   fibrinogen adsorption and all favored albumin adsorption. Copolymers
   based on hydroxyethoxypropyl-PDMS had lower hydrophobicity, higher
   surface free energy and better microphase separation in comparison with
   hydroxypropyl-PDMS-based copolymers, which promoted better endothelial
   cell attachment and growth on the surface of these polymers as compared
   to hydroxypropyl-PDMS-based copolymers. The results showed that SPU-PDMS
   copolymers display good surface properties, depending on the type of
   soft PDMS segments, which can be tailored for biomedical application
   requirements such as biomedical devices for short-and long-term uses.",
journal = "Hemijska Industrija",
title = "Surface characterization, hemo-and cytocompatibility of segmented
 poly(dimethylsiloxane)-based polyurethanes",
number = "6",
volume = "68",
doi = "10.2298/HEMIND141103082P",
pages = "731-741"
}

Pergal, M. V., Brkljačić, J., Tovilović-Kovačević, G., Jovančić, P., Pezo, L., Vasiljević-Radović, D.,& Djonlagić, J.. (2014). Surface characterization, hemo-and cytocompatibility of segmented
 poly(dimethylsiloxane)-based polyurethanes. in Hemijska Industrija, 68(6), 731-741.
https://doi.org/10.2298/HEMIND141103082P

Pergal MV, Brkljačić J, Tovilović-Kovačević G, Jovančić P, Pezo L, Vasiljević-Radović D, Djonlagić J. Surface characterization, hemo-and cytocompatibility of segmented
 poly(dimethylsiloxane)-based polyurethanes. in Hemijska Industrija. 2014;68(6):731-741.
doi:10.2298/HEMIND141103082P .

Pergal, Marija V., Brkljačić, Jelena, Tovilović-Kovačević, Gordana, Jovančić, Petar, Pezo, Lato, Vasiljević-Radović, Dana, Djonlagić, Jasna, "Surface characterization, hemo-and cytocompatibility of segmented
 poly(dimethylsiloxane)-based polyurethanes" in Hemijska Industrija, 68, no. 6 (2014):731-741,
https://doi.org/10.2298/HEMIND141103082P . .