TY  - JOUR
AU  - Brkljača, Nemanja
AU  - Đurović, Saša
AU  - Milošević, Sanja
AU  - Gašić, Uroš
AU  - Panković, Dejana
AU  - Zeković, Zoran
AU  - Pavlić, Branimir
PY  - 2023
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6469
AB  - Cannabis sativa L. known as industrial hemp manifests high capability in the manufacturing of valuable nutraceuticals with health benefits. This study was focused on investigation of chemical profile and bioactive potential of extracts isolated from three hemp varieties (Helena, Marina and Fedora 17). In addition, great attention was directed towards the use of green extraction techniques and maximum utilization of raw material. In that regard conventional (hydrodistillation – HD) and novel extraction techniques (microwave-assisted hydrodistillation – MWHD, supercritical fluid extraction – SFE and microwave-assisted extraction – MAE) were applied for isolating various fractions (essential oil, lipid extracts and liquid extract) with promising bioactive potential. Essential oils and lipid extracts were characterized regarding yield, terpenoid profile determined by GC-MS and in vitro antioxidant activity towards DPPH and ABTS + radicals. Furthermore, the content of two major cannabinoids was determined in plant material and in extract obtained by SFE. Sequential SFE technique allows obtaining lipid extracts in the first step of process as well as raffinates after SFE in the second step. MAE was applied for isolation of polyphenolic fraction from raw materials and SFE raffinates. Polyphenolic content was determined by spectrophotometric assays and UHPLC-Triple-quadrupole-MS. The results suggested that hemp is an excellent source of valuable terpenoid, cannabinoid and polyphenolic antioxidant agents, and further research should be focused on their utilization in dietary supplements and functional foods.
PB  - Elsevier
T2  - Sustainable Chemistry and Pharmacy
T1  - Sequential extraction approach for sustainable recovery of various hemp (Cannabis sativa L.) bioactive compounds
VL  - 35
DO  - 10.1016/j.scp.2023.101213
SP  - 101213
ER  - 

@article{
author = "Brkljača, Nemanja and Đurović, Saša and Milošević, Sanja and Gašić, Uroš and Panković, Dejana and Zeković, Zoran and Pavlić, Branimir",
year = "2023",
abstract = "Cannabis sativa L. known as industrial hemp manifests high capability in the manufacturing of valuable nutraceuticals with health benefits. This study was focused on investigation of chemical profile and bioactive potential of extracts isolated from three hemp varieties (Helena, Marina and Fedora 17). In addition, great attention was directed towards the use of green extraction techniques and maximum utilization of raw material. In that regard conventional (hydrodistillation – HD) and novel extraction techniques (microwave-assisted hydrodistillation – MWHD, supercritical fluid extraction – SFE and microwave-assisted extraction – MAE) were applied for isolating various fractions (essential oil, lipid extracts and liquid extract) with promising bioactive potential. Essential oils and lipid extracts were characterized regarding yield, terpenoid profile determined by GC-MS and in vitro antioxidant activity towards DPPH and ABTS + radicals. Furthermore, the content of two major cannabinoids was determined in plant material and in extract obtained by SFE. Sequential SFE technique allows obtaining lipid extracts in the first step of process as well as raffinates after SFE in the second step. MAE was applied for isolation of polyphenolic fraction from raw materials and SFE raffinates. Polyphenolic content was determined by spectrophotometric assays and UHPLC-Triple-quadrupole-MS. The results suggested that hemp is an excellent source of valuable terpenoid, cannabinoid and polyphenolic antioxidant agents, and further research should be focused on their utilization in dietary supplements and functional foods.",
publisher = "Elsevier",
journal = "Sustainable Chemistry and Pharmacy",
title = "Sequential extraction approach for sustainable recovery of various hemp (Cannabis sativa L.) bioactive compounds",
volume = "35",
doi = "10.1016/j.scp.2023.101213",
pages = "101213"
}

Brkljača, N., Đurović, S., Milošević, S., Gašić, U., Panković, D., Zeković, Z.,& Pavlić, B.. (2023). Sequential extraction approach for sustainable recovery of various hemp (Cannabis sativa L.) bioactive compounds. in Sustainable Chemistry and Pharmacy
Elsevier., 35, 101213.
https://doi.org/10.1016/j.scp.2023.101213

Brkljača N, Đurović S, Milošević S, Gašić U, Panković D, Zeković Z, Pavlić B. Sequential extraction approach for sustainable recovery of various hemp (Cannabis sativa L.) bioactive compounds. in Sustainable Chemistry and Pharmacy. 2023;35:101213.
doi:10.1016/j.scp.2023.101213 .

Brkljača, Nemanja, Đurović, Saša, Milošević, Sanja, Gašić, Uroš, Panković, Dejana, Zeković, Zoran, Pavlić, Branimir, "Sequential extraction approach for sustainable recovery of various hemp (Cannabis sativa L.) bioactive compounds" in Sustainable Chemistry and Pharmacy, 35 (2023):101213,
https://doi.org/10.1016/j.scp.2023.101213 . .

TY  - JOUR
AU  - Đurović, Saša
AU  - Micić, Darko
AU  - Šorgić, Saša
AU  - Popov, Saša
AU  - Gašić, Uroš
AU  - Tosti, Tomislav
AU  - Kostić, Marija
AU  - Smyatskaya, Yulia
AU  - Blagojević, Stevan
AU  - Zeković, Zoran
PY  - 2023
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5668
AB  - Stinging nettle (SN) is an extraordinary plant from the Urticaceae botanical family. It is well-known and widely used in food and folk medicine to treat different disorders and diseases. This article aimed to study the chemical composition of SN leaves extracts, i.e., polyphenolic compounds and vitamins B and C, because many studies ascribed high biological potency to these compounds and their significance in the human diet. Besides the chemical profile, the thermal properties of the extracts were studied. The results confirmed presence of many polyphenolic compounds and vitamins B and C. It also showed that the chemical profile closely correlated with the applied extraction technique. The thermal analysis showed that analyzed samples were thermally stable up to about 160 °C. Thermal degradation of samples UAE, MAE, and MAC took place in four steps, and sample SE in three steps. Altogether, results confirmed the presence of health-beneficial compounds in stinging nettle leaves and indicated the possible application of its extract in pharmaceutical and food industries as both a medicinal and food additive.
PB  - Basel: MDPI
T2  - Molecules
T1  - Recovery of Polyphenolic Compounds and Vitamins from the Stinging Nettle Leaves: Thermal and Behavior and Biological Activity of Obtained Extracts
IS  - 5
VL  - 28
DO  - 10.3390/molecules28052278
SP  - 2278
ER  - 

@article{
author = "Đurović, Saša and Micić, Darko and Šorgić, Saša and Popov, Saša and Gašić, Uroš and Tosti, Tomislav and Kostić, Marija and Smyatskaya, Yulia and Blagojević, Stevan and Zeković, Zoran",
year = "2023",
abstract = "Stinging nettle (SN) is an extraordinary plant from the Urticaceae botanical family. It is well-known and widely used in food and folk medicine to treat different disorders and diseases. This article aimed to study the chemical composition of SN leaves extracts, i.e., polyphenolic compounds and vitamins B and C, because many studies ascribed high biological potency to these compounds and their significance in the human diet. Besides the chemical profile, the thermal properties of the extracts were studied. The results confirmed presence of many polyphenolic compounds and vitamins B and C. It also showed that the chemical profile closely correlated with the applied extraction technique. The thermal analysis showed that analyzed samples were thermally stable up to about 160 °C. Thermal degradation of samples UAE, MAE, and MAC took place in four steps, and sample SE in three steps. Altogether, results confirmed the presence of health-beneficial compounds in stinging nettle leaves and indicated the possible application of its extract in pharmaceutical and food industries as both a medicinal and food additive.",
publisher = "Basel: MDPI",
journal = "Molecules",
title = "Recovery of Polyphenolic Compounds and Vitamins from the Stinging Nettle Leaves: Thermal and Behavior and Biological Activity of Obtained Extracts",
number = "5",
volume = "28",
doi = "10.3390/molecules28052278",
pages = "2278"
}

Đurović, S., Micić, D., Šorgić, S., Popov, S., Gašić, U., Tosti, T., Kostić, M., Smyatskaya, Y., Blagojević, S.,& Zeković, Z.. (2023). Recovery of Polyphenolic Compounds and Vitamins from the Stinging Nettle Leaves: Thermal and Behavior and Biological Activity of Obtained Extracts. in Molecules
Basel: MDPI., 28(5), 2278.
https://doi.org/10.3390/molecules28052278

Đurović S, Micić D, Šorgić S, Popov S, Gašić U, Tosti T, Kostić M, Smyatskaya Y, Blagojević S, Zeković Z. Recovery of Polyphenolic Compounds and Vitamins from the Stinging Nettle Leaves: Thermal and Behavior and Biological Activity of Obtained Extracts. in Molecules. 2023;28(5):2278.
doi:10.3390/molecules28052278 .

Đurović, Saša, Micić, Darko, Šorgić, Saša, Popov, Saša, Gašić, Uroš, Tosti, Tomislav, Kostić, Marija, Smyatskaya, Yulia, Blagojević, Stevan, Zeković, Zoran, "Recovery of Polyphenolic Compounds and Vitamins from the Stinging Nettle Leaves: Thermal and Behavior and Biological Activity of Obtained Extracts" in Molecules, 28, no. 5 (2023):2278,
https://doi.org/10.3390/molecules28052278 . .

TY  - JOUR
AU  - Cvetanović Kljakić, Aleksandra
AU  - Radosavljević, Miloš
AU  - Zengin, Gokhan
AU  - Yan, Linlin
AU  - Gašić, Uroš
AU  - Kojić, Predrag
AU  - Torbica, Aleksandra
AU  - Belović, Miona
AU  - Zeković, Zoran
PY  - 2023
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5667
AB  - Chamomile is one of the most consumed medicinal plants worldwide. Various chamomile preparations are widely used in various branches of both traditional and modern pharmacy. However, in order to obtain an extract with a high content of the desired components, it is necessary to optimize key extraction parameters. In the present study, optimization of process parameters was performed using the artificial neural networks (ANN) model using a solid-to-solvent ratio, microwave power and time as inputs, while the outputs were the yield of the total phenolic compounds (TPC). Optimized extraction conditions were as follows: a solid-to-solvent ratio of 1:80, microwave power of 400 W, extraction time of 30 min. ANN predicted the content of the total phenolic compounds, which was later experimentally confirmed. The extract obtained under optimal conditions was characterized by rich composition and high biological activity. Additionally, chamomile extract showed promising properties as growth media for probiotics. The study could make a valuable scientific contribution to the application of modern statistical designs and modelling to improve extraction techniques
PB  - Basel: MDPI
T2  - Plants
T1  - New Biological and Chemical Insights into Optimization of Chamomile Extracts by Using Artificial Neural Network (ANN) Model
IS  - 6
VL  - 12
DO  - 10.3390/plants12061211
SP  - 1211
ER  - 

@article{
author = "Cvetanović Kljakić, Aleksandra and Radosavljević, Miloš and Zengin, Gokhan and Yan, Linlin and Gašić, Uroš and Kojić, Predrag and Torbica, Aleksandra and Belović, Miona and Zeković, Zoran",
year = "2023",
abstract = "Chamomile is one of the most consumed medicinal plants worldwide. Various chamomile preparations are widely used in various branches of both traditional and modern pharmacy. However, in order to obtain an extract with a high content of the desired components, it is necessary to optimize key extraction parameters. In the present study, optimization of process parameters was performed using the artificial neural networks (ANN) model using a solid-to-solvent ratio, microwave power and time as inputs, while the outputs were the yield of the total phenolic compounds (TPC). Optimized extraction conditions were as follows: a solid-to-solvent ratio of 1:80, microwave power of 400 W, extraction time of 30 min. ANN predicted the content of the total phenolic compounds, which was later experimentally confirmed. The extract obtained under optimal conditions was characterized by rich composition and high biological activity. Additionally, chamomile extract showed promising properties as growth media for probiotics. The study could make a valuable scientific contribution to the application of modern statistical designs and modelling to improve extraction techniques",
publisher = "Basel: MDPI",
journal = "Plants",
title = "New Biological and Chemical Insights into Optimization of Chamomile Extracts by Using Artificial Neural Network (ANN) Model",
number = "6",
volume = "12",
doi = "10.3390/plants12061211",
pages = "1211"
}

Cvetanović Kljakić, A., Radosavljević, M., Zengin, G., Yan, L., Gašić, U., Kojić, P., Torbica, A., Belović, M.,& Zeković, Z.. (2023). New Biological and Chemical Insights into Optimization of Chamomile Extracts by Using Artificial Neural Network (ANN) Model. in Plants
Basel: MDPI., 12(6), 1211.
https://doi.org/10.3390/plants12061211

Cvetanović Kljakić A, Radosavljević M, Zengin G, Yan L, Gašić U, Kojić P, Torbica A, Belović M, Zeković Z. New Biological and Chemical Insights into Optimization of Chamomile Extracts by Using Artificial Neural Network (ANN) Model. in Plants. 2023;12(6):1211.
doi:10.3390/plants12061211 .

Cvetanović Kljakić, Aleksandra, Radosavljević, Miloš, Zengin, Gokhan, Yan, Linlin, Gašić, Uroš, Kojić, Predrag, Torbica, Aleksandra, Belović, Miona, Zeković, Zoran, "New Biological and Chemical Insights into Optimization of Chamomile Extracts by Using Artificial Neural Network (ANN) Model" in Plants, 12, no. 6 (2023):1211,
https://doi.org/10.3390/plants12061211 . .

TY  - JOUR
AU  - Đurović, Saša
AU  - Pezo, Lato
AU  - Gašić, Uroš
AU  - Gorjanović, Stanislava
AU  - Pastor, Ferenc
AU  - Bazarnova, Julia G.
AU  - Smyatskaya, Yulia A.
AU  - Zeković, Zoran
PY  - 2023
UR  - https://www.mdpi.com/2304-8158/12/4/809
UR  - http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC9957156
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5492
AB  - Stinging nettle (Urtica dioica L.) is one fantastic plant widely used in folk medicine, pharmacy, cosmetics, and food. This plant's popularity may be explained by its chemical composition, containing a wide range of compounds significant for human health and diet. This study aimed to investigate extracts of exhausted stinging nettle leaves after supercritical fluid extraction obtained using ultrasound and microwave techniques. Extracts were analyzed to obtain insight into the chemical composition and biological activity. These extracts were shown to be more potent than those of previously untreated leaves. The principal component analysis was applied as a pattern recognition tool to visualize the antioxidant capacity and cytotoxic activity of extract obtained from exhausted stinging nettle leaves. An artificial neural network model is presented for the prediction of the antioxidant activity of samples according to polyphenolic profile data, showing a suitable anticipation property (the r2 value during the training cycle for output variables was 0.999).
PB  - Basel: MDPI
T2  - Foods (Basel, Switzerland)
T1  - Recovery of Biologically Active Compounds from Stinging Nettle Leaves Part II: Processing of Exhausted Plant Material after Supercritical Fluid Extraction
IS  - 4
VL  - 12
DO  - 10.3390/foods12040809
SP  - 809
ER  - 

@article{
author = "Đurović, Saša and Pezo, Lato and Gašić, Uroš and Gorjanović, Stanislava and Pastor, Ferenc and Bazarnova, Julia G. and Smyatskaya, Yulia A. and Zeković, Zoran",
year = "2023",
abstract = "Stinging nettle (Urtica dioica L.) is one fantastic plant widely used in folk medicine, pharmacy, cosmetics, and food. This plant's popularity may be explained by its chemical composition, containing a wide range of compounds significant for human health and diet. This study aimed to investigate extracts of exhausted stinging nettle leaves after supercritical fluid extraction obtained using ultrasound and microwave techniques. Extracts were analyzed to obtain insight into the chemical composition and biological activity. These extracts were shown to be more potent than those of previously untreated leaves. The principal component analysis was applied as a pattern recognition tool to visualize the antioxidant capacity and cytotoxic activity of extract obtained from exhausted stinging nettle leaves. An artificial neural network model is presented for the prediction of the antioxidant activity of samples according to polyphenolic profile data, showing a suitable anticipation property (the r2 value during the training cycle for output variables was 0.999).",
publisher = "Basel: MDPI",
journal = "Foods (Basel, Switzerland)",
title = "Recovery of Biologically Active Compounds from Stinging Nettle Leaves Part II: Processing of Exhausted Plant Material after Supercritical Fluid Extraction",
number = "4",
volume = "12",
doi = "10.3390/foods12040809",
pages = "809"
}

Đurović, S., Pezo, L., Gašić, U., Gorjanović, S., Pastor, F., Bazarnova, J. G., Smyatskaya, Y. A.,& Zeković, Z.. (2023). Recovery of Biologically Active Compounds from Stinging Nettle Leaves Part II: Processing of Exhausted Plant Material after Supercritical Fluid Extraction. in Foods (Basel, Switzerland)
Basel: MDPI., 12(4), 809.
https://doi.org/10.3390/foods12040809

Đurović S, Pezo L, Gašić U, Gorjanović S, Pastor F, Bazarnova JG, Smyatskaya YA, Zeković Z. Recovery of Biologically Active Compounds from Stinging Nettle Leaves Part II: Processing of Exhausted Plant Material after Supercritical Fluid Extraction. in Foods (Basel, Switzerland). 2023;12(4):809.
doi:10.3390/foods12040809 .

Đurović, Saša, Pezo, Lato, Gašić, Uroš, Gorjanović, Stanislava, Pastor, Ferenc, Bazarnova, Julia G., Smyatskaya, Yulia A., Zeković, Zoran, "Recovery of Biologically Active Compounds from Stinging Nettle Leaves Part II: Processing of Exhausted Plant Material after Supercritical Fluid Extraction" in Foods (Basel, Switzerland), 12, no. 4 (2023):809,
https://doi.org/10.3390/foods12040809 . .

TY  - JOUR
AU  - Filip, Snežana
AU  - Đurović, Saša
AU  - Blagojević, Stevan
AU  - Tomić, Ana
AU  - Ranitović, Aleksandra
AU  - Gašić, Uroš
AU  - Tešić, Živoslav
AU  - Zeković, Zoran
PY  - 2020
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4317
AB  - The main goal of this study was to establish the chemical profile of Osage orange (Maclura pomifera) leaf extracts, obtained by conventional maceration technique, and to examine its antimicrobial activity. The identification and quantification of the extract compounds were done using ultra-high-performance liquid chromatography, with a diode array detector coupled with triple-quadrupole mass spectrometer and gas chromatography–mass spectrometry techniques. Thirty-one polyphenolic compounds were detected and identified in the ethanolic extracts, whereby 5-O-caffeoylquinic acid was found to be the dominant compound. Among other compounds, pentacosane and palmitic acid were the most abundant compounds in the dichloromethane extract. The preliminary antimicrobial activity screening shows that Gram-positive bacteria tend to be more sensitive to the investigated extracts. The highest antimicrobial activity was determined against Enterococcus faecalis ATCC 19433 and Listeria monocytogenes ATCC 35152. From these results, Osage orange leaves can be considered as plant material with significant antimicrobial properties.
PB  - Weinheim: Wiley-VCH Verlag Gmbh
T2  - Archiv der Pharmazie
T1  - Chemical composition and antimicrobial activity of Osage orange (Maclura pomifera) leaf extracts
IS  - 2
VL  - 354
DO  - 10.1002/ardp.202000195
SP  - 2000195
ER  - 

@article{
author = "Filip, Snežana and Đurović, Saša and Blagojević, Stevan and Tomić, Ana and Ranitović, Aleksandra and Gašić, Uroš and Tešić, Živoslav and Zeković, Zoran",
year = "2020",
abstract = "The main goal of this study was to establish the chemical profile of Osage orange (Maclura pomifera) leaf extracts, obtained by conventional maceration technique, and to examine its antimicrobial activity. The identification and quantification of the extract compounds were done using ultra-high-performance liquid chromatography, with a diode array detector coupled with triple-quadrupole mass spectrometer and gas chromatography–mass spectrometry techniques. Thirty-one polyphenolic compounds were detected and identified in the ethanolic extracts, whereby 5-O-caffeoylquinic acid was found to be the dominant compound. Among other compounds, pentacosane and palmitic acid were the most abundant compounds in the dichloromethane extract. The preliminary antimicrobial activity screening shows that Gram-positive bacteria tend to be more sensitive to the investigated extracts. The highest antimicrobial activity was determined against Enterococcus faecalis ATCC 19433 and Listeria monocytogenes ATCC 35152. From these results, Osage orange leaves can be considered as plant material with significant antimicrobial properties.",
publisher = "Weinheim: Wiley-VCH Verlag Gmbh",
journal = "Archiv der Pharmazie",
title = "Chemical composition and antimicrobial activity of Osage orange (Maclura pomifera) leaf extracts",
number = "2",
volume = "354",
doi = "10.1002/ardp.202000195",
pages = "2000195"
}

Filip, S., Đurović, S., Blagojević, S., Tomić, A., Ranitović, A., Gašić, U., Tešić, Ž.,& Zeković, Z.. (2020). Chemical composition and antimicrobial activity of Osage orange (Maclura pomifera) leaf extracts. in Archiv der Pharmazie
Weinheim: Wiley-VCH Verlag Gmbh., 354(2), 2000195.
https://doi.org/10.1002/ardp.202000195

Filip S, Đurović S, Blagojević S, Tomić A, Ranitović A, Gašić U, Tešić Ž, Zeković Z. Chemical composition and antimicrobial activity of Osage orange (Maclura pomifera) leaf extracts. in Archiv der Pharmazie. 2020;354(2):2000195.
doi:10.1002/ardp.202000195 .

Filip, Snežana, Đurović, Saša, Blagojević, Stevan, Tomić, Ana, Ranitović, Aleksandra, Gašić, Uroš, Tešić, Živoslav, Zeković, Zoran, "Chemical composition and antimicrobial activity of Osage orange (Maclura pomifera) leaf extracts" in Archiv der Pharmazie, 354, no. 2 (2020):2000195,
https://doi.org/10.1002/ardp.202000195 . .

TY  - JOUR
AU  - Đurović, Saša
AU  - Vujanović, Milena
AU  - Radojković, Marija
AU  - Filipović, Jelena
AU  - Filipović, Vladimir
AU  - Gašić, Uroš
AU  - Tešić, Živoslav
AU  - Mašković, Pavle
AU  - Zeković, Zoran
PY  - 2020
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4067
AB  - Stinging nettle is an annual plant. This plant is known for applications in folk medicine, and as the human diet. The stinging nettle leaves has been used to obtain extracts, which are expected to be with a high content of biologically active compounds. Prepared microwave extracts were applied in the formulation of the functional products. The article completes preparation of the bread with addition of the stinging nettle leaves and its extract, and bread’s composition in phenolic acids, flavonoids, micro elements, and macro elements. The biological activity of the prepared bread samples showed significant antioxidant activity. This was especially true against DPPH radicals. It has been shown that it holds a high cytotoxic activity. Leaves themselves decreased the quality of the bread, while the extract improved the quality. It was sensorially confirmed. The article concluded that the extract substitutes leaves in bread as a product of a high benefit.
PB  - Elsevier Ltd
T2  - Food Chemistry
T1  - The functional food production: Application of stinging nettle leaves and its extracts in the baking of a bread
VL  - 312
DO  - 10.1016/j.foodchem.2019.126091
SP  - 126091
ER  - 

@article{
author = "Đurović, Saša and Vujanović, Milena and Radojković, Marija and Filipović, Jelena and Filipović, Vladimir and Gašić, Uroš and Tešić, Živoslav and Mašković, Pavle and Zeković, Zoran",
year = "2020",
abstract = "Stinging nettle is an annual plant. This plant is known for applications in folk medicine, and as the human diet. The stinging nettle leaves has been used to obtain extracts, which are expected to be with a high content of biologically active compounds. Prepared microwave extracts were applied in the formulation of the functional products. The article completes preparation of the bread with addition of the stinging nettle leaves and its extract, and bread’s composition in phenolic acids, flavonoids, micro elements, and macro elements. The biological activity of the prepared bread samples showed significant antioxidant activity. This was especially true against DPPH radicals. It has been shown that it holds a high cytotoxic activity. Leaves themselves decreased the quality of the bread, while the extract improved the quality. It was sensorially confirmed. The article concluded that the extract substitutes leaves in bread as a product of a high benefit.",
publisher = "Elsevier Ltd",
journal = "Food Chemistry",
title = "The functional food production: Application of stinging nettle leaves and its extracts in the baking of a bread",
volume = "312",
doi = "10.1016/j.foodchem.2019.126091",
pages = "126091"
}

Đurović, S., Vujanović, M., Radojković, M., Filipović, J., Filipović, V., Gašić, U., Tešić, Ž., Mašković, P.,& Zeković, Z.. (2020). The functional food production: Application of stinging nettle leaves and its extracts in the baking of a bread. in Food Chemistry
Elsevier Ltd., 312, 126091.
https://doi.org/10.1016/j.foodchem.2019.126091

Đurović S, Vujanović M, Radojković M, Filipović J, Filipović V, Gašić U, Tešić Ž, Mašković P, Zeković Z. The functional food production: Application of stinging nettle leaves and its extracts in the baking of a bread. in Food Chemistry. 2020;312:126091.
doi:10.1016/j.foodchem.2019.126091 .

Đurović, Saša, Vujanović, Milena, Radojković, Marija, Filipović, Jelena, Filipović, Vladimir, Gašić, Uroš, Tešić, Živoslav, Mašković, Pavle, Zeković, Zoran, "The functional food production: Application of stinging nettle leaves and its extracts in the baking of a bread" in Food Chemistry, 312 (2020):126091,
https://doi.org/10.1016/j.foodchem.2019.126091 . .

TY  - JOUR
AU  - Grdović, Nevena
AU  - Dinić, Svetlana
AU  - Arambašić Jovanović, Jelena
AU  - Mihailović, Mirjana
AU  - Uskoković, Aleksandra
AU  - Marković, Jelena
AU  - Poznanović, Goran
AU  - Vidović, Senka
AU  - Zeković, Zoran
AU  - Mujić, Aida
AU  - Mujić, Ibrahim
AU  - Vidaković, Melita
PY  - 2012
UR  - http://www.journals.cambridge.org/abstract_S0007114511006702
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3198
AB  - Pancreatic β-cell death or dysfunction mediated by oxidative stress underlies the development and progression of diabetes mellitus. In the present study, we tested extracts from the edible mushroom Lactarius deterrimus and the chestnut Castanea sativa, as well as their mixture (MIX Ld/Cs), for potential beneficial effects on streptozotocin (STZ)-induced pancreatic β-cell death. Analysis of chelating effects, reducing power and radical-scavenging assays revealed strong antioxidant effects of the C. sativa extract and MIX Ld/Cs, while the L. deterrimus extract displayed a weak to moderate effect. The antioxidative effect of the chestnut extract corresponds with the high content of phenolics and flavonoids identified by HPLC analysis. In contrast, the mushroom extract contains relatively small amounts of phenols and flavonoids. However, both extracts, and especially their combination MIX Ld/Cs, increased cell viability after the STZ treatment as a result of a significant reduction of DNA damage and improved redox status. The chestnut extract and MIX Ld/Cs significantly lowered the STZ-induced increases in superoxide dismutase and catalase activities, while the mushroom extract had no impact on the activities of these antioxidant enzymes. However, the L. deterrimus extract exhibited good NO-scavenging activity. Different mechanisms that underlie antioxidant effects of the mushroom and chestnut extracts were discussed. When combined as in the MIX Ld/Cs, the extracts exhibited diverse but synergistic actions that ultimately exerted beneficial and protective effects against STZ-induced pancreatic β-cell death.
PB  - Cambridge University Press
T2  - The British Journal of Nutrition
T1  - The protective effect of a mix of Lactarius deterrimus and Castanea sativa extracts on streptozotocin-induced oxidative stress and pancreatic β-cell death
IS  - 7
VL  - 108
DO  - 10.1017/S0007114511006702
SP  - 1163
EP  - 1176
ER  - 

@article{
author = "Grdović, Nevena and Dinić, Svetlana and Arambašić Jovanović, Jelena and Mihailović, Mirjana and Uskoković, Aleksandra and Marković, Jelena and Poznanović, Goran and Vidović, Senka and Zeković, Zoran and Mujić, Aida and Mujić, Ibrahim and Vidaković, Melita",
year = "2012",
abstract = "Pancreatic β-cell death or dysfunction mediated by oxidative stress underlies the development and progression of diabetes mellitus. In the present study, we tested extracts from the edible mushroom Lactarius deterrimus and the chestnut Castanea sativa, as well as their mixture (MIX Ld/Cs), for potential beneficial effects on streptozotocin (STZ)-induced pancreatic β-cell death. Analysis of chelating effects, reducing power and radical-scavenging assays revealed strong antioxidant effects of the C. sativa extract and MIX Ld/Cs, while the L. deterrimus extract displayed a weak to moderate effect. The antioxidative effect of the chestnut extract corresponds with the high content of phenolics and flavonoids identified by HPLC analysis. In contrast, the mushroom extract contains relatively small amounts of phenols and flavonoids. However, both extracts, and especially their combination MIX Ld/Cs, increased cell viability after the STZ treatment as a result of a significant reduction of DNA damage and improved redox status. The chestnut extract and MIX Ld/Cs significantly lowered the STZ-induced increases in superoxide dismutase and catalase activities, while the mushroom extract had no impact on the activities of these antioxidant enzymes. However, the L. deterrimus extract exhibited good NO-scavenging activity. Different mechanisms that underlie antioxidant effects of the mushroom and chestnut extracts were discussed. When combined as in the MIX Ld/Cs, the extracts exhibited diverse but synergistic actions that ultimately exerted beneficial and protective effects against STZ-induced pancreatic β-cell death.",
publisher = "Cambridge University Press",
journal = "The British Journal of Nutrition",
title = "The protective effect of a mix of Lactarius deterrimus and Castanea sativa extracts on streptozotocin-induced oxidative stress and pancreatic β-cell death",
number = "7",
volume = "108",
doi = "10.1017/S0007114511006702",
pages = "1163-1176"
}

Grdović, N., Dinić, S., Arambašić Jovanović, J., Mihailović, M., Uskoković, A., Marković, J., Poznanović, G., Vidović, S., Zeković, Z., Mujić, A., Mujić, I.,& Vidaković, M.. (2012). The protective effect of a mix of Lactarius deterrimus and Castanea sativa extracts on streptozotocin-induced oxidative stress and pancreatic β-cell death. in The British Journal of Nutrition
Cambridge University Press., 108(7), 1163-1176.
https://doi.org/10.1017/S0007114511006702

Grdović N, Dinić S, Arambašić Jovanović J, Mihailović M, Uskoković A, Marković J, Poznanović G, Vidović S, Zeković Z, Mujić A, Mujić I, Vidaković M. The protective effect of a mix of Lactarius deterrimus and Castanea sativa extracts on streptozotocin-induced oxidative stress and pancreatic β-cell death. in The British Journal of Nutrition. 2012;108(7):1163-1176.
doi:10.1017/S0007114511006702 .

Grdović, Nevena, Dinić, Svetlana, Arambašić Jovanović, Jelena, Mihailović, Mirjana, Uskoković, Aleksandra, Marković, Jelena, Poznanović, Goran, Vidović, Senka, Zeković, Zoran, Mujić, Aida, Mujić, Ibrahim, Vidaković, Melita, "The protective effect of a mix of Lactarius deterrimus and Castanea sativa extracts on streptozotocin-induced oxidative stress and pancreatic β-cell death" in The British Journal of Nutrition, 108, no. 7 (2012):1163-1176,
https://doi.org/10.1017/S0007114511006702 . .