TY  - JOUR
AU  - Hadi, Najmeh
AU  - Nikolić, Miloš
AU  - Sefidkon, Fatemeh
AU  - Shojaeiyan, Abdolali
AU  - Šiler, Branislav
AU  - Mišić, Danijela
AU  - Yahyazadeh, Mahdi
PY  - 2023
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6440
AB  - Pathogenic microorganisms are more or less successfully treated by synthetic chemical compounds, whose residues often cause serious health problems. Plant specialized metabolites with antimicrobial properties have for a long time been the focus of both medicine and pharmacology. This study was conducted to evaluate the in vitro antimicrobial activity of methanol extracts of selected endemic and native Iranian Nepeta species against some of the most important pathogenic bacteria and fungi. The results indicated that N. kotschyi leaf extract was the most efficient against the tested bacteria, with Pseudomonas aeruginosa being the most sensitive and fungal species were more susceptible to the extracts than bacterial strains. Nepeta spp. extracts showed a strong antifungal activity against micromycetes, except for quite resistant Aspergillus niger. Antibacterial MIC values (mg.mL-1) ranged from 0.01 (N. kotschyi) to 0.20 (N. crassifolia), while antifungal MIC values ranged from 0.02 (N. crassifolia, N. kotschyi, N. menthoides, and N. cataria) to 0.13 (N. crassifolia and N. menthoides). When compared to positive controls, in most cases the extracts performed much better. The recorded antimicrobial activity candidates the selected 4 endemic and native Iranian Nepeta spp. as prospective and promising antimicrobial agents to be used in both pharmacology and biotechnology.
PB  - CMB Association Publishers
T2  - Cellular and Molecular Biology
T1  - Native and endemic Iranian Nepeta spp.: powerful antimicrobial agents
IS  - 69
VL  - 10
DO  - 10.14715/cmb/2023.69.10.18
SP  - 129
EP  - 135
ER  - 

@article{
author = "Hadi, Najmeh and Nikolić, Miloš and Sefidkon, Fatemeh and Shojaeiyan, Abdolali and Šiler, Branislav and Mišić, Danijela and Yahyazadeh, Mahdi",
year = "2023",
abstract = "Pathogenic microorganisms are more or less successfully treated by synthetic chemical compounds, whose residues often cause serious health problems. Plant specialized metabolites with antimicrobial properties have for a long time been the focus of both medicine and pharmacology. This study was conducted to evaluate the in vitro antimicrobial activity of methanol extracts of selected endemic and native Iranian Nepeta species against some of the most important pathogenic bacteria and fungi. The results indicated that N. kotschyi leaf extract was the most efficient against the tested bacteria, with Pseudomonas aeruginosa being the most sensitive and fungal species were more susceptible to the extracts than bacterial strains. Nepeta spp. extracts showed a strong antifungal activity against micromycetes, except for quite resistant Aspergillus niger. Antibacterial MIC values (mg.mL-1) ranged from 0.01 (N. kotschyi) to 0.20 (N. crassifolia), while antifungal MIC values ranged from 0.02 (N. crassifolia, N. kotschyi, N. menthoides, and N. cataria) to 0.13 (N. crassifolia and N. menthoides). When compared to positive controls, in most cases the extracts performed much better. The recorded antimicrobial activity candidates the selected 4 endemic and native Iranian Nepeta spp. as prospective and promising antimicrobial agents to be used in both pharmacology and biotechnology.",
publisher = "CMB Association Publishers",
journal = "Cellular and Molecular Biology",
title = "Native and endemic Iranian Nepeta spp.: powerful antimicrobial agents",
number = "69",
volume = "10",
doi = "10.14715/cmb/2023.69.10.18",
pages = "129-135"
}

Hadi, N., Nikolić, M., Sefidkon, F., Shojaeiyan, A., Šiler, B., Mišić, D.,& Yahyazadeh, M.. (2023). Native and endemic Iranian Nepeta spp.: powerful antimicrobial agents. in Cellular and Molecular Biology
CMB Association Publishers., 10(69), 129-135.
https://doi.org/10.14715/cmb/2023.69.10.18

Hadi N, Nikolić M, Sefidkon F, Shojaeiyan A, Šiler B, Mišić D, Yahyazadeh M. Native and endemic Iranian Nepeta spp.: powerful antimicrobial agents. in Cellular and Molecular Biology. 2023;10(69):129-135.
doi:10.14715/cmb/2023.69.10.18 .

Hadi, Najmeh, Nikolić, Miloš, Sefidkon, Fatemeh, Shojaeiyan, Abdolali, Šiler, Branislav, Mišić, Danijela, Yahyazadeh, Mahdi, "Native and endemic Iranian Nepeta spp.: powerful antimicrobial agents" in Cellular and Molecular Biology, 10, no. 69 (2023):129-135,
https://doi.org/10.14715/cmb/2023.69.10.18 . .

TY  - JOUR
AU  - Nikolić, Miloš
AU  - Marković, Tatjana
AU  - Marković, Dejan
AU  - Calhelha, Ricardo
AU  - Fernandes, Ângela
AU  - Ferreira, Isabel
AU  - Stojković, Dejan
AU  - Ćirić, Ana
AU  - Glamočlija, Jasmina
AU  - Soković, Marina
PY  - 2021
UR  - http://www.doiserbia.nb.rs/Article.aspx?ID=0352-51392100096N
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/4761
AB  - Chemical composition of the essential oils (EO) of Pelargonium graveolens, Leptospermum petersonii and Cymbopogon martinii var. motia, and the absolute of Rosa centifolia and their bioactivity were examined. Major compounds in P. graveolens EO were monoterpene alcohols citronellol, geraniol and linalool; in L. petersonii EO monoterpene aldehydes geranial, neral and citronellal; in C. martiniii var. motia EO monoterpene alcohol geraniol and ester geranyl acetate, while in absolute of R. centifolia aromatic alcohol 2-phenylethanol. The EO of L. petersonii showed the strongest antibacterial while the EO of C. martinii var. motia the strongest antifungal potential. The best biofilm inhibition capacity was observed with R. centifolia absolute. The results of scanning electron microscopy analysis indicated that the EOs of L. petersonii and P. graveolens changed the number and morphology of C. albicans cells. The L. petersonii EO was the most potent toward tumour cells and exhibited the best biological activity. This is first comparative report summarizing efficacy of studied aromatic samples against pathogenic microbes, providing deeper insight into the modes of antimicrobial action, and at the same time describing their cytotoxicity against cell lines.
PB  - Belgrade: Serbian Chemical Socitey
T2  - Journal of the Serbian Chemical Society
T1  - Chemical composition and biological properties of Pelargonium graveolens, Leptospermum petersonii and Cymbopogon martinii var. motia essential oils and of Rosa centifolia absolute
IS  - 12
VL  - 86
DO  - 10.2298/JSC210729096N
SP  - 1291
EP  - 1303
ER  - 

@article{
author = "Nikolić, Miloš and Marković, Tatjana and Marković, Dejan and Calhelha, Ricardo and Fernandes, Ângela and Ferreira, Isabel and Stojković, Dejan and Ćirić, Ana and Glamočlija, Jasmina and Soković, Marina",
year = "2021",
abstract = "Chemical composition of the essential oils (EO) of Pelargonium graveolens, Leptospermum petersonii and Cymbopogon martinii var. motia, and the absolute of Rosa centifolia and their bioactivity were examined. Major compounds in P. graveolens EO were monoterpene alcohols citronellol, geraniol and linalool; in L. petersonii EO monoterpene aldehydes geranial, neral and citronellal; in C. martiniii var. motia EO monoterpene alcohol geraniol and ester geranyl acetate, while in absolute of R. centifolia aromatic alcohol 2-phenylethanol. The EO of L. petersonii showed the strongest antibacterial while the EO of C. martinii var. motia the strongest antifungal potential. The best biofilm inhibition capacity was observed with R. centifolia absolute. The results of scanning electron microscopy analysis indicated that the EOs of L. petersonii and P. graveolens changed the number and morphology of C. albicans cells. The L. petersonii EO was the most potent toward tumour cells and exhibited the best biological activity. This is first comparative report summarizing efficacy of studied aromatic samples against pathogenic microbes, providing deeper insight into the modes of antimicrobial action, and at the same time describing their cytotoxicity against cell lines.",
publisher = "Belgrade: Serbian Chemical Socitey",
journal = "Journal of the Serbian Chemical Society",
title = "Chemical composition and biological properties of Pelargonium graveolens, Leptospermum petersonii and Cymbopogon martinii var. motia essential oils and of Rosa centifolia absolute",
number = "12",
volume = "86",
doi = "10.2298/JSC210729096N",
pages = "1291-1303"
}

Nikolić, M., Marković, T., Marković, D., Calhelha, R., Fernandes, Â., Ferreira, I., Stojković, D., Ćirić, A., Glamočlija, J.,& Soković, M.. (2021). Chemical composition and biological properties of Pelargonium graveolens, Leptospermum petersonii and Cymbopogon martinii var. motia essential oils and of Rosa centifolia absolute. in Journal of the Serbian Chemical Society
Belgrade: Serbian Chemical Socitey., 86(12), 1291-1303.
https://doi.org/10.2298/JSC210729096N

Nikolić M, Marković T, Marković D, Calhelha R, Fernandes Â, Ferreira I, Stojković D, Ćirić A, Glamočlija J, Soković M. Chemical composition and biological properties of Pelargonium graveolens, Leptospermum petersonii and Cymbopogon martinii var. motia essential oils and of Rosa centifolia absolute. in Journal of the Serbian Chemical Society. 2021;86(12):1291-1303.
doi:10.2298/JSC210729096N .

Nikolić, Miloš, Marković, Tatjana, Marković, Dejan, Calhelha, Ricardo, Fernandes, Ângela, Ferreira, Isabel, Stojković, Dejan, Ćirić, Ana, Glamočlija, Jasmina, Soković, Marina, "Chemical composition and biological properties of Pelargonium graveolens, Leptospermum petersonii and Cymbopogon martinii var. motia essential oils and of Rosa centifolia absolute" in Journal of the Serbian Chemical Society, 86, no. 12 (2021):1291-1303,
https://doi.org/10.2298/JSC210729096N . .

TY  - JOUR
AU  - Stojković, Dejan
AU  - Nikolić, Miloš
AU  - Soković, Marina
PY  - 2020
UR  - https://www.eurekaselect.com/187524/article
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3998
T2  - Current Medicinal Chemistry
T2  - Current Medicinal Chemistry
T1  - Medicinal Plants and Mushrooms as Unfailing Source of Pharmacological Active Molecules for the Treatment and Supportive Therapy in Chronic Diseases and Conditions
IS  - 41
VL  - 27
DO  - 10.2174/092986732741201103103456
SP  - 6891
EP  - 6891
ER  - 

@article{
author = "Stojković, Dejan and Nikolić, Miloš and Soković, Marina",
year = "2020",
journal = "Current Medicinal Chemistry, Current Medicinal Chemistry",
title = "Medicinal Plants and Mushrooms as Unfailing Source of Pharmacological Active Molecules for the Treatment and Supportive Therapy in Chronic Diseases and Conditions",
number = "41",
volume = "27",
doi = "10.2174/092986732741201103103456",
pages = "6891-6891"
}

Stojković, D., Nikolić, M.,& Soković, M.. (2020). Medicinal Plants and Mushrooms as Unfailing Source of Pharmacological Active Molecules for the Treatment and Supportive Therapy in Chronic Diseases and Conditions. in Current Medicinal Chemistry, 27(41), 6891-6891.
https://doi.org/10.2174/092986732741201103103456

Stojković D, Nikolić M, Soković M. Medicinal Plants and Mushrooms as Unfailing Source of Pharmacological Active Molecules for the Treatment and Supportive Therapy in Chronic Diseases and Conditions. in Current Medicinal Chemistry. 2020;27(41):6891-6891.
doi:10.2174/092986732741201103103456 .

Stojković, Dejan, Nikolić, Miloš, Soković, Marina, "Medicinal Plants and Mushrooms as Unfailing Source of Pharmacological Active Molecules for the Treatment and Supportive Therapy in Chronic Diseases and Conditions" in Current Medicinal Chemistry, 27, no. 41 (2020):6891-6891,
https://doi.org/10.2174/092986732741201103103456 . .

TY  - JOUR
AU  - Stojković, Dejan
AU  - Kostić, Marina
AU  - Ivanov, Marija
AU  - Aleksić, Milena
AU  - Vasiljević, Perica
AU  - Nikolić, Miloš
AU  - Soković, Marina
PY  - 2020
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4059
AB  - The following review is oriented towards microbes linked to Alzheimer’s disease (AD) and antimicrobial effect of compounds and extracts derived from aquatic organisms against specific bacteria, fungi and viruses which were found previously in patients suffering from AD. Major group of microbes linked to AD include bacteria: Chlamydia pneumoniae, Helicobacter pylori, Porphyromonas gingivalis, Fusobacterium nucleatum, Prevotella intermedia, Actinomyces naeslundii, spirochete group; fungi: Candida sp., Cryptococcus sp., Saccharomyces sp., Malassezia sp., Botrytis sp., and viruses: herpes simplex virus type 1 (HSV-1), Human cytomegalovirus (CMV), hepatitis C virus (HCV). In the light of that fact, this review is the first to link antimicrobial potential of aquatic organisms against these sorts of microbes. This literature review might serve as a starting platform to develop novel supportive therapy for patients suffering from AD and to possibly prevent escalation of the disease in patients already having high-risk factors for AD occurrence.
PB  - Bentham Science Publishers
T2  - Current Medicinal Chemistry
T1  - Linking Antimicrobial Potential of Natural Products Derived from Aquatic Organisms and Microbes Involved in Alzheimer's Disease - A Review
IS  - 26
VL  - 27
DO  - 10.2174/0929867325666180309103645
SP  - 4372
EP  - 4391
ER  - 

@article{
author = "Stojković, Dejan and Kostić, Marina and Ivanov, Marija and Aleksić, Milena and Vasiljević, Perica and Nikolić, Miloš and Soković, Marina",
year = "2020",
abstract = "The following review is oriented towards microbes linked to Alzheimer’s disease (AD) and antimicrobial effect of compounds and extracts derived from aquatic organisms against specific bacteria, fungi and viruses which were found previously in patients suffering from AD. Major group of microbes linked to AD include bacteria: Chlamydia pneumoniae, Helicobacter pylori, Porphyromonas gingivalis, Fusobacterium nucleatum, Prevotella intermedia, Actinomyces naeslundii, spirochete group; fungi: Candida sp., Cryptococcus sp., Saccharomyces sp., Malassezia sp., Botrytis sp., and viruses: herpes simplex virus type 1 (HSV-1), Human cytomegalovirus (CMV), hepatitis C virus (HCV). In the light of that fact, this review is the first to link antimicrobial potential of aquatic organisms against these sorts of microbes. This literature review might serve as a starting platform to develop novel supportive therapy for patients suffering from AD and to possibly prevent escalation of the disease in patients already having high-risk factors for AD occurrence.",
publisher = "Bentham Science Publishers",
journal = "Current Medicinal Chemistry",
title = "Linking Antimicrobial Potential of Natural Products Derived from Aquatic Organisms and Microbes Involved in Alzheimer's Disease - A Review",
number = "26",
volume = "27",
doi = "10.2174/0929867325666180309103645",
pages = "4372-4391"
}

Stojković, D., Kostić, M., Ivanov, M., Aleksić, M., Vasiljević, P., Nikolić, M.,& Soković, M.. (2020). Linking Antimicrobial Potential of Natural Products Derived from Aquatic Organisms and Microbes Involved in Alzheimer's Disease - A Review. in Current Medicinal Chemistry
Bentham Science Publishers., 27(26), 4372-4391.
https://doi.org/10.2174/0929867325666180309103645

Stojković D, Kostić M, Ivanov M, Aleksić M, Vasiljević P, Nikolić M, Soković M. Linking Antimicrobial Potential of Natural Products Derived from Aquatic Organisms and Microbes Involved in Alzheimer's Disease - A Review. in Current Medicinal Chemistry. 2020;27(26):4372-4391.
doi:10.2174/0929867325666180309103645 .

Stojković, Dejan, Kostić, Marina, Ivanov, Marija, Aleksić, Milena, Vasiljević, Perica, Nikolić, Miloš, Soković, Marina, "Linking Antimicrobial Potential of Natural Products Derived from Aquatic Organisms and Microbes Involved in Alzheimer's Disease - A Review" in Current Medicinal Chemistry, 27, no. 26 (2020):4372-4391,
https://doi.org/10.2174/0929867325666180309103645 . .

TY  - JOUR
AU  - Ćirić, Ana
AU  - Petrović, Jovana
AU  - Glamočlija, Jasmina
AU  - Ivanov, Marija
AU  - Nikolić, Miloš
AU  - Stojković, Dejan
AU  - Soković, Marina
PY  - 2019
UR  - https://www.sciencedirect.com/science/article/pii/S0254629918309256?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3170
AB  - Quorum sensing (QS) are defined as an entire set of bacterial behaviors: biofilm formation, bioluminescence, conjugation and virulence, antibiotic production, competence, conjugation, swarming, motility and sporulation. The present review foccuses on QS properties of bacteria and yeasts and influence of natural matrices on supression of QS function in pathogenic microorganisms. This review covers an update of scientific works, on products of natural origin as anti-QS agents. Plant, bacteria, fungi, sponge, and algae species and their isolated principal components, are highlighted as promising materials with high anti-QS capacities on various bacteria and yeasts. Special emphasis was given to anti-QS capacities of natural matrices on Pseudomonas aeruginosa, as one of the safest models systems for studies in the area of QS inhibition. Future trends in anti-QS drugs development are briefly discussed.
T2  - South African Journal of Botany
T1  - Natural products as biofilm formation antagonists and regulators of quorum sensing functions: A comprehensive review update and future trends
VL  - 120
DO  - 10.1016/J.SAJB.2018.09.010
SP  - 65
EP  - 80
ER  - 

@article{
author = "Ćirić, Ana and Petrović, Jovana and Glamočlija, Jasmina and Ivanov, Marija and Nikolić, Miloš and Stojković, Dejan and Soković, Marina",
year = "2019",
abstract = "Quorum sensing (QS) are defined as an entire set of bacterial behaviors: biofilm formation, bioluminescence, conjugation and virulence, antibiotic production, competence, conjugation, swarming, motility and sporulation. The present review foccuses on QS properties of bacteria and yeasts and influence of natural matrices on supression of QS function in pathogenic microorganisms. This review covers an update of scientific works, on products of natural origin as anti-QS agents. Plant, bacteria, fungi, sponge, and algae species and their isolated principal components, are highlighted as promising materials with high anti-QS capacities on various bacteria and yeasts. Special emphasis was given to anti-QS capacities of natural matrices on Pseudomonas aeruginosa, as one of the safest models systems for studies in the area of QS inhibition. Future trends in anti-QS drugs development are briefly discussed.",
journal = "South African Journal of Botany",
title = "Natural products as biofilm formation antagonists and regulators of quorum sensing functions: A comprehensive review update and future trends",
volume = "120",
doi = "10.1016/J.SAJB.2018.09.010",
pages = "65-80"
}

Ćirić, A., Petrović, J., Glamočlija, J., Ivanov, M., Nikolić, M., Stojković, D.,& Soković, M.. (2019). Natural products as biofilm formation antagonists and regulators of quorum sensing functions: A comprehensive review update and future trends. in South African Journal of Botany, 120, 65-80.
https://doi.org/10.1016/J.SAJB.2018.09.010

Ćirić A, Petrović J, Glamočlija J, Ivanov M, Nikolić M, Stojković D, Soković M. Natural products as biofilm formation antagonists and regulators of quorum sensing functions: A comprehensive review update and future trends. in South African Journal of Botany. 2019;120:65-80.
doi:10.1016/J.SAJB.2018.09.010 .

Ćirić, Ana, Petrović, Jovana, Glamočlija, Jasmina, Ivanov, Marija, Nikolić, Miloš, Stojković, Dejan, Soković, Marina, "Natural products as biofilm formation antagonists and regulators of quorum sensing functions: A comprehensive review update and future trends" in South African Journal of Botany, 120 (2019):65-80,
https://doi.org/10.1016/J.SAJB.2018.09.010 . .

TY  - JOUR
AU  - Bukvički, Danka
AU  - Giweli, Abdulhmid
AU  - Stojković, Dejan
AU  - Vujisić, Ljubodrag
AU  - Tešević, Vele
AU  - Nikolić, Miloš
AU  - Soković, Marina
AU  - Marin, Petar D
PY  - 2018
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3032
UR  - http://www.journalofdairyscience.org/article/S0022-0302(18)30148-6/fulltext
AB  - The essential oil of Thymus algeriensis was analyzed as a potential preservative in soft cheese. We developed a novel method to test the preserving properties of essential oil in soft cheese. Contamination incidence of Penicillium aurantiogriseum was absent after 30 d of storage at 4°C with 25 µL of essential oil added. The antimicrobial activity was tested against 8 bacteria and 8 fungi. Thymus algeriensis oil showed inhibitory activity against tested bacteria at 0.03 to 0.09 mg/mL, and bactericidal activity was achieved at 0.05 to 0.15 mg/mL. For antifungal activity, minimum inhibitory concentrations ranged between 0.01 and 0.04 mg/mL and minimum fungicidal concentrations between 0.01 and 0.04 mg/mL. Furthermore, the oil was also screened for antiradical activity using the 1,1-diphenyl-2-picrylhydrazyl assay. The results showed that the oil was active and achieved half-maximal inhibitory activity at 0.132 mg/mL. We used gas chromatography, gas chromatography-mass spectrometry, and nuclear magnetic resonance spectrometry to investigate the volatile compounds from the oil. Carvacrol was identified as the main compound in the oil, represented by 80.9% of the total constituents, followed by p-cymene (7.7%).
T2  - Journal of Dairy Science
T1  - Short communication: Cheese supplemented with Thymus algeriensis oil, a potential natural food preservative.
IS  - 5
VL  - 101
DO  - 10.3168/jds.2017-13714
SP  - 3859
EP  - 3865
ER  - 

@article{
author = "Bukvički, Danka and Giweli, Abdulhmid and Stojković, Dejan and Vujisić, Ljubodrag and Tešević, Vele and Nikolić, Miloš and Soković, Marina and Marin, Petar D",
year = "2018",
abstract = "The essential oil of Thymus algeriensis was analyzed as a potential preservative in soft cheese. We developed a novel method to test the preserving properties of essential oil in soft cheese. Contamination incidence of Penicillium aurantiogriseum was absent after 30 d of storage at 4°C with 25 µL of essential oil added. The antimicrobial activity was tested against 8 bacteria and 8 fungi. Thymus algeriensis oil showed inhibitory activity against tested bacteria at 0.03 to 0.09 mg/mL, and bactericidal activity was achieved at 0.05 to 0.15 mg/mL. For antifungal activity, minimum inhibitory concentrations ranged between 0.01 and 0.04 mg/mL and minimum fungicidal concentrations between 0.01 and 0.04 mg/mL. Furthermore, the oil was also screened for antiradical activity using the 1,1-diphenyl-2-picrylhydrazyl assay. The results showed that the oil was active and achieved half-maximal inhibitory activity at 0.132 mg/mL. We used gas chromatography, gas chromatography-mass spectrometry, and nuclear magnetic resonance spectrometry to investigate the volatile compounds from the oil. Carvacrol was identified as the main compound in the oil, represented by 80.9% of the total constituents, followed by p-cymene (7.7%).",
journal = "Journal of Dairy Science",
title = "Short communication: Cheese supplemented with Thymus algeriensis oil, a potential natural food preservative.",
number = "5",
volume = "101",
doi = "10.3168/jds.2017-13714",
pages = "3859-3865"
}

Bukvički, D., Giweli, A., Stojković, D., Vujisić, L., Tešević, V., Nikolić, M., Soković, M.,& Marin, P. D.. (2018). Short communication: Cheese supplemented with Thymus algeriensis oil, a potential natural food preservative.. in Journal of Dairy Science, 101(5), 3859-3865.
https://doi.org/10.3168/jds.2017-13714

Bukvički D, Giweli A, Stojković D, Vujisić L, Tešević V, Nikolić M, Soković M, Marin PD. Short communication: Cheese supplemented with Thymus algeriensis oil, a potential natural food preservative.. in Journal of Dairy Science. 2018;101(5):3859-3865.
doi:10.3168/jds.2017-13714 .

Bukvički, Danka, Giweli, Abdulhmid, Stojković, Dejan, Vujisić, Ljubodrag, Tešević, Vele, Nikolić, Miloš, Soković, Marina, Marin, Petar D, "Short communication: Cheese supplemented with Thymus algeriensis oil, a potential natural food preservative." in Journal of Dairy Science, 101, no. 5 (2018):3859-3865,
https://doi.org/10.3168/jds.2017-13714 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Ćirić, Ana
AU  - Dimitrić Marković, Jasmina
AU  - Glamočlija, Jasmina
AU  - Nikolić, Miloš
AU  - Soković, Marina
PY  - 2017
UR  - https://www.tandfonline.com/doi/full/10.1080/14786419.2016.1222386
UR  - http://www.ncbi.nlm.nih.gov/pubmed/27539815
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2623
AB  - Anti-biofilm activity of three anthocyanidins (pelargonidin, cyanidin and delphinidin) was evaluated for the first time at in vitro conditions. All the compounds reduced the formation of Pseudomonas aeruginosa PAO1 biofilm at low sub-MIC (0.125 MIC) with delphinidin (c 56.25 μg/mL) being the most active (43%). In comparison, ampicillin (c 93.75 μg/mL) and streptomycin (c 21.25 μg/mL) (used as positive controls) were considerably less effective at the same sub-MIC (8 and 12%, respectively). Furthermore, at 0.5 MIC (c 225 μg/mL) this anthocyanidin molecule partly reduced the bacterial protrusions. However, no any of the aforementioned compounds inhibited the production of pyocyanin by the bacterial strain P. aeruginosa PAO1. Taken all together, the delphinidin scaffold could be taken into consideration for the design of the novel and more effective anti-biofilm agents inspired by the anthocyanidins.
T2  - Natural product research
T1  - An insight into anti-biofilm and anti-quorum sensing activities of the selected anthocyanidins: the case study of Pseudomonas aeruginosa PAO1.
IS  - 10
VL  - 31
DO  - 10.1080/14786419.2016.1222386
SP  - 1177
EP  - 1180
ER  - 

@article{
author = "Pejin, Boris and Ćirić, Ana and Dimitrić Marković, Jasmina and Glamočlija, Jasmina and Nikolić, Miloš and Soković, Marina",
year = "2017",
abstract = "Anti-biofilm activity of three anthocyanidins (pelargonidin, cyanidin and delphinidin) was evaluated for the first time at in vitro conditions. All the compounds reduced the formation of Pseudomonas aeruginosa PAO1 biofilm at low sub-MIC (0.125 MIC) with delphinidin (c 56.25 μg/mL) being the most active (43%). In comparison, ampicillin (c 93.75 μg/mL) and streptomycin (c 21.25 μg/mL) (used as positive controls) were considerably less effective at the same sub-MIC (8 and 12%, respectively). Furthermore, at 0.5 MIC (c 225 μg/mL) this anthocyanidin molecule partly reduced the bacterial protrusions. However, no any of the aforementioned compounds inhibited the production of pyocyanin by the bacterial strain P. aeruginosa PAO1. Taken all together, the delphinidin scaffold could be taken into consideration for the design of the novel and more effective anti-biofilm agents inspired by the anthocyanidins.",
journal = "Natural product research",
title = "An insight into anti-biofilm and anti-quorum sensing activities of the selected anthocyanidins: the case study of Pseudomonas aeruginosa PAO1.",
number = "10",
volume = "31",
doi = "10.1080/14786419.2016.1222386",
pages = "1177-1180"
}

Pejin, B., Ćirić, A., Dimitrić Marković, J., Glamočlija, J., Nikolić, M.,& Soković, M.. (2017). An insight into anti-biofilm and anti-quorum sensing activities of the selected anthocyanidins: the case study of Pseudomonas aeruginosa PAO1.. in Natural product research, 31(10), 1177-1180.
https://doi.org/10.1080/14786419.2016.1222386

Pejin B, Ćirić A, Dimitrić Marković J, Glamočlija J, Nikolić M, Soković M. An insight into anti-biofilm and anti-quorum sensing activities of the selected anthocyanidins: the case study of Pseudomonas aeruginosa PAO1.. in Natural product research. 2017;31(10):1177-1180.
doi:10.1080/14786419.2016.1222386 .

Pejin, Boris, Ćirić, Ana, Dimitrić Marković, Jasmina, Glamočlija, Jasmina, Nikolić, Miloš, Soković, Marina, "An insight into anti-biofilm and anti-quorum sensing activities of the selected anthocyanidins: the case study of Pseudomonas aeruginosa PAO1." in Natural product research, 31, no. 10 (2017):1177-1180,
https://doi.org/10.1080/14786419.2016.1222386 . .

TY  - JOUR
AU  - Nikolić, Miloš
AU  - Jovanović, Katarina
AU  - Marković, Tatjana
AU  - Marković, Dejan
AU  - Gligorijević, Nevenka
AU  - Radulović, Siniša
AU  - Kostić, Marina
AU  - Glamočlija, Jasmina
AU  - Soković, Marina
PY  - 2017
UR  - http://doi.wiley.com/10.1111/jphp.12792
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2875
AB  - Objectives: The chemical composition, antimicrobial and synergistic effect, and cytotoxic activity of Citrus limon (lemon), Piper nigrum (green pepper) and Melaleuca alternifoila (tea tree) essential oils (EOs) were investigated. Methods: Chemical analyses of essential oils were tested by GC-FID and GC-MS spectroscopy. The antimicrobial activity assay was conducted using microdilution method against several oral bacteria and Candida spp. originating from the humans with oral disorders. The synergistic antimicrobial activity was evaluated using checkerboard method. The cytotoxicity evaluation of EOs was assessed using MTT test. Key findings: Limonene (37.5%) and β-pinene (17.9%) were the major compounds in C. limon oil, β-pinene (34.4%), δ-3-carene (19.7%), limonene (18.7%) and α-pinene (10.4%) in P. nigrum oil and terpinen-4-ol (38.6%) and γ-terpinene (21.7%) in M. alternifolia oil. The broad-spectrum antimicrobial activity was achieved by tested three EOs, with C. limon oil being the strongest against bacteria and M. alternifolia oil strongest against fungi. The EOs demonstrated synergism; their combined application revealed an increase in antimicrobial activity. All tested essential oils showed lower cytotoxic activity in comparison with the positive control, and the obtained results confirmed a dose-dependent activity. Conclusions: The results of this study encourage use of tested EOs in development of a novel agent intended for prevention or therapy of corresponding oral disorders.
T2  - Journal of Pharmacy and Pharmacology
T1  - Antimicrobial synergism and cytotoxic properties of Citrus limon L., Piper nigrum L. and Melaleuca alternifolia (Maiden and Betche) Cheel essential oils
IS  - 11
VL  - 69
DO  - 10.1111/jphp.12792
SP  - 1606
EP  - 1614
ER  - 

@article{
author = "Nikolić, Miloš and Jovanović, Katarina and Marković, Tatjana and Marković, Dejan and Gligorijević, Nevenka and Radulović, Siniša and Kostić, Marina and Glamočlija, Jasmina and Soković, Marina",
year = "2017",
abstract = "Objectives: The chemical composition, antimicrobial and synergistic effect, and cytotoxic activity of Citrus limon (lemon), Piper nigrum (green pepper) and Melaleuca alternifoila (tea tree) essential oils (EOs) were investigated. Methods: Chemical analyses of essential oils were tested by GC-FID and GC-MS spectroscopy. The antimicrobial activity assay was conducted using microdilution method against several oral bacteria and Candida spp. originating from the humans with oral disorders. The synergistic antimicrobial activity was evaluated using checkerboard method. The cytotoxicity evaluation of EOs was assessed using MTT test. Key findings: Limonene (37.5%) and β-pinene (17.9%) were the major compounds in C. limon oil, β-pinene (34.4%), δ-3-carene (19.7%), limonene (18.7%) and α-pinene (10.4%) in P. nigrum oil and terpinen-4-ol (38.6%) and γ-terpinene (21.7%) in M. alternifolia oil. The broad-spectrum antimicrobial activity was achieved by tested three EOs, with C. limon oil being the strongest against bacteria and M. alternifolia oil strongest against fungi. The EOs demonstrated synergism; their combined application revealed an increase in antimicrobial activity. All tested essential oils showed lower cytotoxic activity in comparison with the positive control, and the obtained results confirmed a dose-dependent activity. Conclusions: The results of this study encourage use of tested EOs in development of a novel agent intended for prevention or therapy of corresponding oral disorders.",
journal = "Journal of Pharmacy and Pharmacology",
title = "Antimicrobial synergism and cytotoxic properties of Citrus limon L., Piper nigrum L. and Melaleuca alternifolia (Maiden and Betche) Cheel essential oils",
number = "11",
volume = "69",
doi = "10.1111/jphp.12792",
pages = "1606-1614"
}

Nikolić, M., Jovanović, K., Marković, T., Marković, D., Gligorijević, N., Radulović, S., Kostić, M., Glamočlija, J.,& Soković, M.. (2017). Antimicrobial synergism and cytotoxic properties of Citrus limon L., Piper nigrum L. and Melaleuca alternifolia (Maiden and Betche) Cheel essential oils. in Journal of Pharmacy and Pharmacology, 69(11), 1606-1614.
https://doi.org/10.1111/jphp.12792

Nikolić M, Jovanović K, Marković T, Marković D, Gligorijević N, Radulović S, Kostić M, Glamočlija J, Soković M. Antimicrobial synergism and cytotoxic properties of Citrus limon L., Piper nigrum L. and Melaleuca alternifolia (Maiden and Betche) Cheel essential oils. in Journal of Pharmacy and Pharmacology. 2017;69(11):1606-1614.
doi:10.1111/jphp.12792 .

Nikolić, Miloš, Jovanović, Katarina, Marković, Tatjana, Marković, Dejan, Gligorijević, Nevenka, Radulović, Siniša, Kostić, Marina, Glamočlija, Jasmina, Soković, Marina, "Antimicrobial synergism and cytotoxic properties of Citrus limon L., Piper nigrum L. and Melaleuca alternifolia (Maiden and Betche) Cheel essential oils" in Journal of Pharmacy and Pharmacology, 69, no. 11 (2017):1606-1614,
https://doi.org/10.1111/jphp.12792 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Ćirić, Ana
AU  - Karaman, Ivo
AU  - Horvatovic, Mladen
AU  - Glamočlija, Jasmina
AU  - Nikolić, Miloš
AU  - Soković, Marina
PY  - 2016
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6752
AB  - The antibiofilm and possible antiquorum sensing effects against 
the strain Pseudomonas aeruginosa PAO1 of five crude extracts 
of the freshwater bryozoan Hyalinella punctata (Hancock, 1850)
were evaluated in vitro for the first time. H. punctata ethyl acetate 
extract (HpEtAc) exhibited the highest antibiofilm activity reducing 
the biofilm formation of P. aeruginosa PAO1 in the range of 80.63–
88.13%. While all tested extracts reduced the twitching motility of 
the aforementioned bacterial strain, HpEtAc showed to be the most 
effective. Finally, at a concentration of 0.5 MIC, the same extract 
mostly inhibited the production of pyocyanin by P. aeruginosa
PAO1 (71.53%). In comparison both with the positive controls used 
(streptomycin and ampicillin, 67.13 and 69.77%, respectively), HpEtAc 
was found to inhibit pyocyanin in a higher extent. An extensive 
chemical characterisation of this particular extract may result in 
isolation and identification of novel lead compounds targeting 
P. aeruginosa, an opportunistic human pathogen.
PB  - Abingdon: Taylor and Francis
T2  - Natural Product Research
T1  - In vitro antibiofilm activity of the freshwater bryozoan  Hyalinella punctata: a case study of Pseudomonas aeruginosa PAO1
IS  - 16
VL  - 30
DO  - 10.1080/14786419.2015.1072714
SP  - 1847
EP  - 1850
ER  - 

@article{
author = "Pejin, Boris and Ćirić, Ana and Karaman, Ivo and Horvatovic, Mladen and Glamočlija, Jasmina and Nikolić, Miloš and Soković, Marina",
year = "2016",
abstract = "The antibiofilm and possible antiquorum sensing effects against 
the strain Pseudomonas aeruginosa PAO1 of five crude extracts 
of the freshwater bryozoan Hyalinella punctata (Hancock, 1850)
were evaluated in vitro for the first time. H. punctata ethyl acetate 
extract (HpEtAc) exhibited the highest antibiofilm activity reducing 
the biofilm formation of P. aeruginosa PAO1 in the range of 80.63–
88.13%. While all tested extracts reduced the twitching motility of 
the aforementioned bacterial strain, HpEtAc showed to be the most 
effective. Finally, at a concentration of 0.5 MIC, the same extract 
mostly inhibited the production of pyocyanin by P. aeruginosa
PAO1 (71.53%). In comparison both with the positive controls used 
(streptomycin and ampicillin, 67.13 and 69.77%, respectively), HpEtAc 
was found to inhibit pyocyanin in a higher extent. An extensive 
chemical characterisation of this particular extract may result in 
isolation and identification of novel lead compounds targeting 
P. aeruginosa, an opportunistic human pathogen.",
publisher = "Abingdon: Taylor and Francis",
journal = "Natural Product Research",
title = "In vitro antibiofilm activity of the freshwater bryozoan  Hyalinella punctata: a case study of Pseudomonas aeruginosa PAO1",
number = "16",
volume = "30",
doi = "10.1080/14786419.2015.1072714",
pages = "1847-1850"
}

Pejin, B., Ćirić, A., Karaman, I., Horvatovic, M., Glamočlija, J., Nikolić, M.,& Soković, M.. (2016). In vitro antibiofilm activity of the freshwater bryozoan  Hyalinella punctata: a case study of Pseudomonas aeruginosa PAO1. in Natural Product Research
Abingdon: Taylor and Francis., 30(16), 1847-1850.
https://doi.org/10.1080/14786419.2015.1072714

Pejin B, Ćirić A, Karaman I, Horvatovic M, Glamočlija J, Nikolić M, Soković M. In vitro antibiofilm activity of the freshwater bryozoan  Hyalinella punctata: a case study of Pseudomonas aeruginosa PAO1. in Natural Product Research. 2016;30(16):1847-1850.
doi:10.1080/14786419.2015.1072714 .

Pejin, Boris, Ćirić, Ana, Karaman, Ivo, Horvatovic, Mladen, Glamočlija, Jasmina, Nikolić, Miloš, Soković, Marina, "In vitro antibiofilm activity of the freshwater bryozoan  Hyalinella punctata: a case study of Pseudomonas aeruginosa PAO1" in Natural Product Research, 30, no. 16 (2016):1847-1850,
https://doi.org/10.1080/14786419.2015.1072714 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Ćirić, Ana
AU  - Horvatovic, Mladen
AU  - Jurca, Tamara
AU  - Glamočlija, Jasmina
AU  - Nikolić, Miloš
AU  - Soković, Marina
PY  - 2016
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6753
AB  - The antimicrobial activity of five crude extracts of the freshwater 
bryozoan Pectinatella magnifica (Leidy, 1851) was evaluated in 
vitro for the first time. P. magnifica acetone extract exhibited the 
highest antibacterial activity (minimum inhibitory concentrations 
(MIC) 0.004–0.350 mg/mL and MBC 0.007–0.500 mg/mL), while its 
methanol extract showed the most promising antifungal activity 
(MIC 0.03–0.12 mg/mL and MFC 0.06–0.25 mg/mL). Furthermore, at 
a concentration of 0.25 MIC, the methanol extract reduced biofilm 
formation of the bacterial strain Pseudomonas aeruginosa PAO1 
in a considerable extent (59.14%). FTIR spectra of the most active 
extracts indicate the presence of carbonyl compounds, long-chain 
alcohols and/or sterols. According to the experimental data obtained, 
P. magnifica methanol extract may be considered as a good resource 
of novel natural products with potent antibiofilm activity against the 
bacterium well known for its resistance.
PB  - Abingdon: Taylor and Francis
T2  - Natural Product Research
T1  - An insight into antimicrobial activity of the freshwater bryozoan Pectinatella magnifica
IS  - 16
VL  - 30
DO  - 10.1080/14786419.2015.1068773
SP  - 1839
EP  - 1843
ER  - 

@article{
author = "Pejin, Boris and Ćirić, Ana and Horvatovic, Mladen and Jurca, Tamara and Glamočlija, Jasmina and Nikolić, Miloš and Soković, Marina",
year = "2016",
abstract = "The antimicrobial activity of five crude extracts of the freshwater 
bryozoan Pectinatella magnifica (Leidy, 1851) was evaluated in 
vitro for the first time. P. magnifica acetone extract exhibited the 
highest antibacterial activity (minimum inhibitory concentrations 
(MIC) 0.004–0.350 mg/mL and MBC 0.007–0.500 mg/mL), while its 
methanol extract showed the most promising antifungal activity 
(MIC 0.03–0.12 mg/mL and MFC 0.06–0.25 mg/mL). Furthermore, at 
a concentration of 0.25 MIC, the methanol extract reduced biofilm 
formation of the bacterial strain Pseudomonas aeruginosa PAO1 
in a considerable extent (59.14%). FTIR spectra of the most active 
extracts indicate the presence of carbonyl compounds, long-chain 
alcohols and/or sterols. According to the experimental data obtained, 
P. magnifica methanol extract may be considered as a good resource 
of novel natural products with potent antibiofilm activity against the 
bacterium well known for its resistance.",
publisher = "Abingdon: Taylor and Francis",
journal = "Natural Product Research",
title = "An insight into antimicrobial activity of the freshwater bryozoan Pectinatella magnifica",
number = "16",
volume = "30",
doi = "10.1080/14786419.2015.1068773",
pages = "1839-1843"
}

Pejin, B., Ćirić, A., Horvatovic, M., Jurca, T., Glamočlija, J., Nikolić, M.,& Soković, M.. (2016). An insight into antimicrobial activity of the freshwater bryozoan Pectinatella magnifica. in Natural Product Research
Abingdon: Taylor and Francis., 30(16), 1839-1843.
https://doi.org/10.1080/14786419.2015.1068773

Pejin B, Ćirić A, Horvatovic M, Jurca T, Glamočlija J, Nikolić M, Soković M. An insight into antimicrobial activity of the freshwater bryozoan Pectinatella magnifica. in Natural Product Research. 2016;30(16):1839-1843.
doi:10.1080/14786419.2015.1068773 .

Pejin, Boris, Ćirić, Ana, Horvatovic, Mladen, Jurca, Tamara, Glamočlija, Jasmina, Nikolić, Miloš, Soković, Marina, "An insight into antimicrobial activity of the freshwater bryozoan Pectinatella magnifica" in Natural Product Research, 30, no. 16 (2016):1839-1843,
https://doi.org/10.1080/14786419.2015.1068773 . .

TY  - JOUR
AU  - Spasojević, Dragica
AU  - Zmejkoski, Danica
AU  - Glamočlija, Jasmina
AU  - Nikolić, Miloš
AU  - Soković, Marina
AU  - Milošević, Verica
AU  - Jarić, Ivana
AU  - Stojanović, Marijana
AU  - Marinković, Emilija
AU  - Barisani-Asenbauer, Talin
AU  - Prodanović, Radivoje
AU  - Jovanović, Miloš
AU  - Radotić, Ksenija
PY  - 2016
UR  - http://linkinghub.elsevier.com/retrieve/pii/S0924857916302679
UR  - https://www.scopus.com/record/display.uri?eid=2-s2.0-85000995852&origin=SingleRecordEmailAlert&dgcid=scalert_sc_search_email&txGid=5EA0B882AD39CF37A9F768C8B10917B5.wsnAw8kcdt7IPYLO0V48gA%3A1#
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2480
AB  - Nowadays bacterial resistance to known antibiotics is a serious health problem. In order to achieve more efficient treatment, lately there is an effort to find new substances, such as certain biomaterials, that are non-toxic to humans with antibiotic potential. Lignins and lignin-derived compounds have been proposed to be good candidates for use in medicine and health maintenance. In this study, the antibacterial activity of the lignin model polymer dehydrogenate polymer (DHP) in alginate hydrogel (Alg) was studied. The obtained results show that DHP−Alg has strong antimicrobial activity against several bacterial strains and biofilms and does not have a toxic effect on human epithelial cells. These results strongly suggest its application as a wound healing agent or as an adjunct substance for wound treatments.
T2  - International Journal of Antimicrobial Agents
T1  - Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment
IS  - 6
VL  - 48
DO  - 10.1016/j.ijantimicag.2016.08.014
SP  - 732
EP  - 735
ER  - 

@article{
author = "Spasojević, Dragica and Zmejkoski, Danica and Glamočlija, Jasmina and Nikolić, Miloš and Soković, Marina and Milošević, Verica and Jarić, Ivana and Stojanović, Marijana and Marinković, Emilija and Barisani-Asenbauer, Talin and Prodanović, Radivoje and Jovanović, Miloš and Radotić, Ksenija",
year = "2016",
abstract = "Nowadays bacterial resistance to known antibiotics is a serious health problem. In order to achieve more efficient treatment, lately there is an effort to find new substances, such as certain biomaterials, that are non-toxic to humans with antibiotic potential. Lignins and lignin-derived compounds have been proposed to be good candidates for use in medicine and health maintenance. In this study, the antibacterial activity of the lignin model polymer dehydrogenate polymer (DHP) in alginate hydrogel (Alg) was studied. The obtained results show that DHP−Alg has strong antimicrobial activity against several bacterial strains and biofilms and does not have a toxic effect on human epithelial cells. These results strongly suggest its application as a wound healing agent or as an adjunct substance for wound treatments.",
journal = "International Journal of Antimicrobial Agents",
title = "Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment",
number = "6",
volume = "48",
doi = "10.1016/j.ijantimicag.2016.08.014",
pages = "732-735"
}

Spasojević, D., Zmejkoski, D., Glamočlija, J., Nikolić, M., Soković, M., Milošević, V., Jarić, I., Stojanović, M., Marinković, E., Barisani-Asenbauer, T., Prodanović, R., Jovanović, M.,& Radotić, K.. (2016). Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment. in International Journal of Antimicrobial Agents, 48(6), 732-735.
https://doi.org/10.1016/j.ijantimicag.2016.08.014

Spasojević D, Zmejkoski D, Glamočlija J, Nikolić M, Soković M, Milošević V, Jarić I, Stojanović M, Marinković E, Barisani-Asenbauer T, Prodanović R, Jovanović M, Radotić K. Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment. in International Journal of Antimicrobial Agents. 2016;48(6):732-735.
doi:10.1016/j.ijantimicag.2016.08.014 .

Spasojević, Dragica, Zmejkoski, Danica, Glamočlija, Jasmina, Nikolić, Miloš, Soković, Marina, Milošević, Verica, Jarić, Ivana, Stojanović, Marijana, Marinković, Emilija, Barisani-Asenbauer, Talin, Prodanović, Radivoje, Jovanović, Miloš, Radotić, Ksenija, "Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment" in International Journal of Antimicrobial Agents, 48, no. 6 (2016):732-735,
https://doi.org/10.1016/j.ijantimicag.2016.08.014 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Ćirić, Ana
AU  - Glamočlija, Jasmina
AU  - Nikolić, Miloš
AU  - Soković, Marina
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2002
AB  - Anti-quorum sensing activity of the diterpene phytol was evaluated in
   vitro for the first time. This compound (at three sub-MIC concentrations
   - 0.5, 0.25 and 0.125 MIC, respectively) reduced the formation of
   Pseudomonas aeruginosa PAO1 biofilm in the range of 74.00-84.33\%
   exhibiting higher activity than the both positive controls used,
   streptomycin and ampicillin. Phytol (0.5 MIC) also effectively reduced
   P. aeruginosa twitching and flagella motility. Indeed, the bacteria
   treated were incapable of producing a twitching zone and had almost
   round, smooth and regular colony edges. Finally, the tested compound
   (0.5 MIC) exhibited good P. aeruginosa pyocyanin inhibitory activity
   (51.94\%) practically to the same extent as streptomycin (52.09\%).
   According to the experimental data obtained, this phytol property may
   inspire design of medical foods targeting P. aeruginosa quorum sensing
   activity.
T2  - Natural Product Research
T1  - In vitro anti-quorum sensing activity of phytol
IS  - 4
VL  - 29
DO  - 10.1080/14786419.2014.945088
SP  - 374
EP  - 377
ER  - 

@article{
author = "Pejin, Boris and Ćirić, Ana and Glamočlija, Jasmina and Nikolić, Miloš and Soković, Marina",
year = "2015",
abstract = "Anti-quorum sensing activity of the diterpene phytol was evaluated in
   vitro for the first time. This compound (at three sub-MIC concentrations
   - 0.5, 0.25 and 0.125 MIC, respectively) reduced the formation of
   Pseudomonas aeruginosa PAO1 biofilm in the range of 74.00-84.33\%
   exhibiting higher activity than the both positive controls used,
   streptomycin and ampicillin. Phytol (0.5 MIC) also effectively reduced
   P. aeruginosa twitching and flagella motility. Indeed, the bacteria
   treated were incapable of producing a twitching zone and had almost
   round, smooth and regular colony edges. Finally, the tested compound
   (0.5 MIC) exhibited good P. aeruginosa pyocyanin inhibitory activity
   (51.94\%) practically to the same extent as streptomycin (52.09\%).
   According to the experimental data obtained, this phytol property may
   inspire design of medical foods targeting P. aeruginosa quorum sensing
   activity.",
journal = "Natural Product Research",
title = "In vitro anti-quorum sensing activity of phytol",
number = "4",
volume = "29",
doi = "10.1080/14786419.2014.945088",
pages = "374-377"
}

Pejin, B., Ćirić, A., Glamočlija, J., Nikolić, M.,& Soković, M.. (2015). In vitro anti-quorum sensing activity of phytol. in Natural Product Research, 29(4), 374-377.
https://doi.org/10.1080/14786419.2014.945088

Pejin B, Ćirić A, Glamočlija J, Nikolić M, Soković M. In vitro anti-quorum sensing activity of phytol. in Natural Product Research. 2015;29(4):374-377.
doi:10.1080/14786419.2014.945088 .

Pejin, Boris, Ćirić, Ana, Glamočlija, Jasmina, Nikolić, Miloš, Soković, Marina, "In vitro anti-quorum sensing activity of phytol" in Natural Product Research, 29, no. 4 (2015):374-377,
https://doi.org/10.1080/14786419.2014.945088 . .

TY  - JOUR
AU  - Bukvicki, Danka
AU  - Stojković, Dejan
AU  - Soković, Marina
AU  - Nikolić, Miloš
AU  - Vannini, Lucia
AU  - Montanari, Chiara
AU  - Marin, Petar D.
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1913
AB  - Chemical composition of Micromeria dalmatica essential oil (EO) by gas
   chromatography mass spectrometry solid phase microextraction
   (GC/MS-SPME) analysis revealed that the dominant compounds were
   piperitenone (41.46\%), pulegone (19.02\%), piperitenone oxide
   (14.49\%), D-limonene (6.23\%) and p-menthone (5.06\%). The minimum
   inhibitory concentration (MIC) ranged from 0.03 to 2.32 mg/mL for
   bacteria, and from 0.62 to 2.49 mg/mL for yeast strains, while the
   minimum bactericidal/yeast-cidal concentration (MBC/MYC) varied from
   0.07 to 1.15 mg/mL and 1.11-5.57 mg/mL for bacteria and yeasts,
   respectively. Growth inhibition concentration (GIC(50)) that caused 50\%
   of growth delay of Salmonella Typhimurium in pork meat system was
   calculated to be 0.048 mg/mL. Experimental results suggest that M.
   dalmatica EO possess high antimicrobial efficacy against food spoilage
   microorganisms. The present study has certainly set up an attractive
   platform for commercial applications of EO as natural preservative in
   food, such as pork meat. (C) 2015 Elsevier Ltd. All rights reserved.
T2  - Lwt-Food Science and Technology
T1  - Potential application of Micromeria dalmatica essential oil as a
 protective agent in a food system
IS  - 1
VL  - 63
DO  - 10.1016/j.lwt.2015.03.053
SP  - 262
EP  - 267
ER  - 

@article{
author = "Bukvicki, Danka and Stojković, Dejan and Soković, Marina and Nikolić, Miloš and Vannini, Lucia and Montanari, Chiara and Marin, Petar D.",
year = "2015",
abstract = "Chemical composition of Micromeria dalmatica essential oil (EO) by gas
   chromatography mass spectrometry solid phase microextraction
   (GC/MS-SPME) analysis revealed that the dominant compounds were
   piperitenone (41.46\%), pulegone (19.02\%), piperitenone oxide
   (14.49\%), D-limonene (6.23\%) and p-menthone (5.06\%). The minimum
   inhibitory concentration (MIC) ranged from 0.03 to 2.32 mg/mL for
   bacteria, and from 0.62 to 2.49 mg/mL for yeast strains, while the
   minimum bactericidal/yeast-cidal concentration (MBC/MYC) varied from
   0.07 to 1.15 mg/mL and 1.11-5.57 mg/mL for bacteria and yeasts,
   respectively. Growth inhibition concentration (GIC(50)) that caused 50\%
   of growth delay of Salmonella Typhimurium in pork meat system was
   calculated to be 0.048 mg/mL. Experimental results suggest that M.
   dalmatica EO possess high antimicrobial efficacy against food spoilage
   microorganisms. The present study has certainly set up an attractive
   platform for commercial applications of EO as natural preservative in
   food, such as pork meat. (C) 2015 Elsevier Ltd. All rights reserved.",
journal = "Lwt-Food Science and Technology",
title = "Potential application of Micromeria dalmatica essential oil as a
 protective agent in a food system",
number = "1",
volume = "63",
doi = "10.1016/j.lwt.2015.03.053",
pages = "262-267"
}

Bukvicki, D., Stojković, D., Soković, M., Nikolić, M., Vannini, L., Montanari, C.,& Marin, P. D.. (2015). Potential application of Micromeria dalmatica essential oil as a
 protective agent in a food system. in Lwt-Food Science and Technology, 63(1), 262-267.
https://doi.org/10.1016/j.lwt.2015.03.053

Bukvicki D, Stojković D, Soković M, Nikolić M, Vannini L, Montanari C, Marin PD. Potential application of Micromeria dalmatica essential oil as a
 protective agent in a food system. in Lwt-Food Science and Technology. 2015;63(1):262-267.
doi:10.1016/j.lwt.2015.03.053 .

Bukvicki, Danka, Stojković, Dejan, Soković, Marina, Nikolić, Miloš, Vannini, Lucia, Montanari, Chiara, Marin, Petar D., "Potential application of Micromeria dalmatica essential oil as a
 protective agent in a food system" in Lwt-Food Science and Technology, 63, no. 1 (2015):262-267,
https://doi.org/10.1016/j.lwt.2015.03.053 . .

TY  - JOUR
AU  - Nikolić, Miloš
AU  - Stojković, Dejan
AU  - Glamočlija, Jasmina
AU  - Ćirić, Ana
AU  - Markovic, Tatjana
AU  - Ivanov, Marija
AU  - Soković, Marina
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2357
AB  - Black and green pepper essential oils were used in this study in order
   to determine the chemical composition, in vitro antimicrobial activity
   against food spoilage microorganisms and in situ oils effect on food
   microorganism, after incorporation in chicken soup, by suggested
   methodology for calculation of Growth inhibition concentrations
   (GIC(50)). Chemical analysis revealed a total of 34 components. The
   major constituent of black pepper oil was trans-caryophyllene (30.33
   \%), followed by limonene (12.12 \%), while beta-pinene (24.42 \%),
   delta(3)-carene (19.72 \%), limonene (18.73 \%) and alpha-pinene (10.39
   \%) were dominant compounds in green pepper oil. Antimicrobial activity
   was determined by microdilution technique and minimal inhibitory (MIC)
   and minimal bactericidal/fungicidal concentrations (MBC/MFC) were
   determined. Green pepper oil showed stronger antibacterial and
   antifungal activity (MIC 0.50-1.87; MBC 0.63-2.5 mg/ml; MIC 0.07-0.16;
   MFC 0.13-1.25 mg/ml) against black pepper oil (MIC 0.07-3.75; MBC
   0.60-10.00 mg/ml; MIC 0.63-5.00; MFC 1.25-10.00 mg/ml. Oils successfully
   inhibited the growth of S. aureus in chicken soup in a dose dependent
   manner. GIC(50) values were calculated after 24, 48 and 72 h and were in
   range of 0.156-0.689 mg/ml. The 50 \% inhibitory concentrations (IC50)
   of EOs were 36.84 and 38.77 mg/ml with in 2, 2-diphenyl-1-picrylhydrazyl
   (DPPH) assay respectively.
   The obtained results revealed that black and green pepper volatiles are
   efficient in controlling the growth of known food-spoilage
   microorganisms.
T2  - Journal of Food Science and Technology-Mysore
T1  - Could essential oils of green and black pepper be used as food
 preservatives?
IS  - 10
VL  - 52
DO  - 10.1007/s13197-015-1792-5
SP  - 6565
EP  - 6573
ER  - 

@article{
author = "Nikolić, Miloš and Stojković, Dejan and Glamočlija, Jasmina and Ćirić, Ana and Markovic, Tatjana and Ivanov, Marija and Soković, Marina",
year = "2015",
abstract = "Black and green pepper essential oils were used in this study in order
   to determine the chemical composition, in vitro antimicrobial activity
   against food spoilage microorganisms and in situ oils effect on food
   microorganism, after incorporation in chicken soup, by suggested
   methodology for calculation of Growth inhibition concentrations
   (GIC(50)). Chemical analysis revealed a total of 34 components. The
   major constituent of black pepper oil was trans-caryophyllene (30.33
   \%), followed by limonene (12.12 \%), while beta-pinene (24.42 \%),
   delta(3)-carene (19.72 \%), limonene (18.73 \%) and alpha-pinene (10.39
   \%) were dominant compounds in green pepper oil. Antimicrobial activity
   was determined by microdilution technique and minimal inhibitory (MIC)
   and minimal bactericidal/fungicidal concentrations (MBC/MFC) were
   determined. Green pepper oil showed stronger antibacterial and
   antifungal activity (MIC 0.50-1.87; MBC 0.63-2.5 mg/ml; MIC 0.07-0.16;
   MFC 0.13-1.25 mg/ml) against black pepper oil (MIC 0.07-3.75; MBC
   0.60-10.00 mg/ml; MIC 0.63-5.00; MFC 1.25-10.00 mg/ml. Oils successfully
   inhibited the growth of S. aureus in chicken soup in a dose dependent
   manner. GIC(50) values were calculated after 24, 48 and 72 h and were in
   range of 0.156-0.689 mg/ml. The 50 \% inhibitory concentrations (IC50)
   of EOs were 36.84 and 38.77 mg/ml with in 2, 2-diphenyl-1-picrylhydrazyl
   (DPPH) assay respectively.
   The obtained results revealed that black and green pepper volatiles are
   efficient in controlling the growth of known food-spoilage
   microorganisms.",
journal = "Journal of Food Science and Technology-Mysore",
title = "Could essential oils of green and black pepper be used as food
 preservatives?",
number = "10",
volume = "52",
doi = "10.1007/s13197-015-1792-5",
pages = "6565-6573"
}

Nikolić, M., Stojković, D., Glamočlija, J., Ćirić, A., Markovic, T., Ivanov, M.,& Soković, M.. (2015). Could essential oils of green and black pepper be used as food
 preservatives?. in Journal of Food Science and Technology-Mysore, 52(10), 6565-6573.
https://doi.org/10.1007/s13197-015-1792-5

Nikolić M, Stojković D, Glamočlija J, Ćirić A, Markovic T, Ivanov M, Soković M. Could essential oils of green and black pepper be used as food
 preservatives?. in Journal of Food Science and Technology-Mysore. 2015;52(10):6565-6573.
doi:10.1007/s13197-015-1792-5 .

Nikolić, Miloš, Stojković, Dejan, Glamočlija, Jasmina, Ćirić, Ana, Markovic, Tatjana, Ivanov, Marija, Soković, Marina, "Could essential oils of green and black pepper be used as food
 preservatives?" in Journal of Food Science and Technology-Mysore, 52, no. 10 (2015):6565-6573,
https://doi.org/10.1007/s13197-015-1792-5 . .

TY  - JOUR
AU  - Glamočlija, Jasmina
AU  - Ćirić, Ana
AU  - Nikolić, Miloš
AU  - Fernandes, Angela
AU  - Barros, Lillian
AU  - Calhelha, Ricardo C.
AU  - Ferreira, Isabel C. F. R.
AU  - Soković, Marina
AU  - van Griensven, Leo J. L. D.
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1989
AB  - Ethnopharmacological relevance: In Russian traditional medicine, an
   extract from the mushroom Inonotus obliquus (Fr.) Pil at is used as an
   anti-tumor medicine and diuretic. It has been reported that Inonotus
   obliquus has therapeutic effects, such as anti-inflammatory,
   immuno-modulatory and hepatoprotective effects. This study was designed
   to investigate the chemical composition and biological properties of
   aqueous and ethanolic extracts of Inonotus obliquus from Finland,
   Russia, and Thailand. Their antioxidative, antimicrobial, and antiquorum
   properties were tested as well as the cytotoxicity on various tumor cell
   lines.
   Materials and methods: The tested extract was subjected to conventional
   chemical study to identified organic acids and phenolic compounds.
   Antioxidative activity was measured by several different assays.
   Antimicrobial potential of extracts was tested by microdilution method,
   and antiquorum sensing activity and antibiofilm formation of Inonotus
   obliquus extracts was tested on Pseudomonas aeruginosa. Cytotoxicity of
   the extracts was tested on tumor cells (MCF-7, NCI-H460, HeLa and
   HepG(2)) and non-tumor liver cells primary cultures.
   Results: Oxalic acid was found as the main organic acid, with the
   highest amount in the aqueous extract from Russia. Gallic,
   protocatechuic and p-hydroxybenzoic acids were detected in all samples.
   Inonotus obliquus extracts showed high antioxidant and antimicrobial
   activity. Extracts were tested at subMIC for anti-quorum sensing (AQS)
   activity in Pseudomonas aeruginosa and all extracts showed definite AQS
   activity. The assays were done using twitching and swarming of bacterial
   cultures, and the amount of produced pyocyanin as QS parameters. All the
   extracts demonstrated cytotoxic effect on four tumor cell lines and not
   on primary porcine liver cells PLP2.
   Conclusions: As the Inonotus obliquus presence in Chaga conks is
   limited, further purification is necessary to draw quantitative
   conclusions. The presence of AQS activity in medicinal mushrooms
   suggests a broader anti-infectious disease protection than only
   immunomodulatory effects. (C) 2015 Elsevier Ireland Ltd. All rights
   reserved.
T2  - Journal of Ethnopharmacology
T1  - Chemical characterization and biological activity of Chaga (Inonotus
 obliquus), a medicinal "mushroom"
VL  - 162
DO  - 10.1016/j.jep.2014.12.069
SP  - 323
EP  - 332
ER  - 

@article{
author = "Glamočlija, Jasmina and Ćirić, Ana and Nikolić, Miloš and Fernandes, Angela and Barros, Lillian and Calhelha, Ricardo C. and Ferreira, Isabel C. F. R. and Soković, Marina and van Griensven, Leo J. L. D.",
year = "2015",
abstract = "Ethnopharmacological relevance: In Russian traditional medicine, an
   extract from the mushroom Inonotus obliquus (Fr.) Pil at is used as an
   anti-tumor medicine and diuretic. It has been reported that Inonotus
   obliquus has therapeutic effects, such as anti-inflammatory,
   immuno-modulatory and hepatoprotective effects. This study was designed
   to investigate the chemical composition and biological properties of
   aqueous and ethanolic extracts of Inonotus obliquus from Finland,
   Russia, and Thailand. Their antioxidative, antimicrobial, and antiquorum
   properties were tested as well as the cytotoxicity on various tumor cell
   lines.
   Materials and methods: The tested extract was subjected to conventional
   chemical study to identified organic acids and phenolic compounds.
   Antioxidative activity was measured by several different assays.
   Antimicrobial potential of extracts was tested by microdilution method,
   and antiquorum sensing activity and antibiofilm formation of Inonotus
   obliquus extracts was tested on Pseudomonas aeruginosa. Cytotoxicity of
   the extracts was tested on tumor cells (MCF-7, NCI-H460, HeLa and
   HepG(2)) and non-tumor liver cells primary cultures.
   Results: Oxalic acid was found as the main organic acid, with the
   highest amount in the aqueous extract from Russia. Gallic,
   protocatechuic and p-hydroxybenzoic acids were detected in all samples.
   Inonotus obliquus extracts showed high antioxidant and antimicrobial
   activity. Extracts were tested at subMIC for anti-quorum sensing (AQS)
   activity in Pseudomonas aeruginosa and all extracts showed definite AQS
   activity. The assays were done using twitching and swarming of bacterial
   cultures, and the amount of produced pyocyanin as QS parameters. All the
   extracts demonstrated cytotoxic effect on four tumor cell lines and not
   on primary porcine liver cells PLP2.
   Conclusions: As the Inonotus obliquus presence in Chaga conks is
   limited, further purification is necessary to draw quantitative
   conclusions. The presence of AQS activity in medicinal mushrooms
   suggests a broader anti-infectious disease protection than only
   immunomodulatory effects. (C) 2015 Elsevier Ireland Ltd. All rights
   reserved.",
journal = "Journal of Ethnopharmacology",
title = "Chemical characterization and biological activity of Chaga (Inonotus
 obliquus), a medicinal "mushroom"",
volume = "162",
doi = "10.1016/j.jep.2014.12.069",
pages = "323-332"
}

Glamočlija, J., Ćirić, A., Nikolić, M., Fernandes, A., Barros, L., Calhelha, R. C., Ferreira, I. C. F. R., Soković, M.,& van Griensven, L. J. L. D.. (2015). Chemical characterization and biological activity of Chaga (Inonotus
 obliquus), a medicinal "mushroom". in Journal of Ethnopharmacology, 162, 323-332.
https://doi.org/10.1016/j.jep.2014.12.069

Glamočlija J, Ćirić A, Nikolić M, Fernandes A, Barros L, Calhelha RC, Ferreira ICFR, Soković M, van Griensven LJLD. Chemical characterization and biological activity of Chaga (Inonotus
 obliquus), a medicinal "mushroom". in Journal of Ethnopharmacology. 2015;162:323-332.
doi:10.1016/j.jep.2014.12.069 .

Glamočlija, Jasmina, Ćirić, Ana, Nikolić, Miloš, Fernandes, Angela, Barros, Lillian, Calhelha, Ricardo C., Ferreira, Isabel C. F. R., Soković, Marina, van Griensven, Leo J. L. D., "Chemical characterization and biological activity of Chaga (Inonotus
 obliquus), a medicinal "mushroom"" in Journal of Ethnopharmacology, 162 (2015):323-332,
https://doi.org/10.1016/j.jep.2014.12.069 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Ćirić, Ana
AU  - Markovic, Jasmina D.
AU  - Glamočlija, Jasmina
AU  - Nikolić, Miloš
AU  - Stanimirovic, Bojana
AU  - Soković, Marina
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2061
AB  - This work was focused on in vitro evaluation of anti-biofilm and
   anti-quorum sensing effects of four selected flavonoid compounds
   /(+)-catechin, caffeic acid, quercetin and morin/using the strain
   Pseudomonas aeruginosa PAO1. At a concentration of 0.5 MIC quercetin was
   the only compound found to potently reduce both P. aeruginosa biofilm
   formation (95\%) and its twitching motility. The chemical scaffold of
   quercetin, a common dietary polyphenol, may actually inspire development
   of novel and more effective medicinal agents targeting P. aeruginosa,
   the bacterium well known for its resistance.
T2  - Current Pharmaceutical Biotechnology
T1  - Quercetin Potently Reduces Biofilm Formation of the Strain Pseudomonas
 aeruginosa PAO1 in vitro
IS  - 8
VL  - 16
SP  - 733
EP  - 737
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_2061
ER  - 

@article{
author = "Pejin, Boris and Ćirić, Ana and Markovic, Jasmina D. and Glamočlija, Jasmina and Nikolić, Miloš and Stanimirovic, Bojana and Soković, Marina",
year = "2015",
abstract = "This work was focused on in vitro evaluation of anti-biofilm and
   anti-quorum sensing effects of four selected flavonoid compounds
   /(+)-catechin, caffeic acid, quercetin and morin/using the strain
   Pseudomonas aeruginosa PAO1. At a concentration of 0.5 MIC quercetin was
   the only compound found to potently reduce both P. aeruginosa biofilm
   formation (95\%) and its twitching motility. The chemical scaffold of
   quercetin, a common dietary polyphenol, may actually inspire development
   of novel and more effective medicinal agents targeting P. aeruginosa,
   the bacterium well known for its resistance.",
journal = "Current Pharmaceutical Biotechnology",
title = "Quercetin Potently Reduces Biofilm Formation of the Strain Pseudomonas
 aeruginosa PAO1 in vitro",
number = "8",
volume = "16",
pages = "733-737",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_2061"
}

Pejin, B., Ćirić, A., Markovic, J. D., Glamočlija, J., Nikolić, M., Stanimirovic, B.,& Soković, M.. (2015). Quercetin Potently Reduces Biofilm Formation of the Strain Pseudomonas
 aeruginosa PAO1 in vitro. in Current Pharmaceutical Biotechnology, 16(8), 733-737.
https://hdl.handle.net/21.15107/rcub_ibiss_2061

Pejin B, Ćirić A, Markovic JD, Glamočlija J, Nikolić M, Stanimirovic B, Soković M. Quercetin Potently Reduces Biofilm Formation of the Strain Pseudomonas
 aeruginosa PAO1 in vitro. in Current Pharmaceutical Biotechnology. 2015;16(8):733-737.
https://hdl.handle.net/21.15107/rcub_ibiss_2061 .

Pejin, Boris, Ćirić, Ana, Markovic, Jasmina D., Glamočlija, Jasmina, Nikolić, Miloš, Stanimirovic, Bojana, Soković, Marina, "Quercetin Potently Reduces Biofilm Formation of the Strain Pseudomonas
 aeruginosa PAO1 in vitro" in Current Pharmaceutical Biotechnology, 16, no. 8 (2015):733-737,
https://hdl.handle.net/21.15107/rcub_ibiss_2061 .

TY  - JOUR
AU  - Glamočlija, Jasmina
AU  - Stojković, Dejan
AU  - Nikolić, Miloš
AU  - Ćirić, Ana
AU  - Reis, Filipa S.
AU  - Barros, Lillian
AU  - Ferreira, Isabel C. F. R.
AU  - Soković, Marina
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2059
AB  - Agaricus bisporus is a cultivated mushroom; A. bitorquis, A. campestris
   and A. macrosporus are edible mushrooms growing wild in nature. A
   chemical characterization was carried out with samples that originated
   in Serbia. Antioxidant, antimicrobial and anti-quorum sensing properties
   of their methanolic and ethanolic extracts were assessed. A. campestris
   had the lowest caloric value and total sugar content and showed the
   highest concentration in organic and phenolic acids, as also in
   tocopherols (mainly gamma-tocopherol). In general, the methanolic
   extracts showed higher antioxidant, but lower antibacterial and
   antifungal potential than ethanolic ones. Sub-inhibitory concentrations
   of the ethanolic extracts demonstrated reduction of virulence factors,
   AQ inhibition zones, twitching and swimming motility. The biofilm
   forming capability of P. aeruginosa PAO1 was also reduced in a
   concentration-dependent manner at sub-MIC values. The extracts of the
   tested Agaricus species are a promising source of antioxidant,
   antimicrobial and antiquorum sensing compounds.
T2  - Food & Function
T1  - A comparative study on edible Agaricus mushrooms as functional foods
IS  - 6
VL  - 6
DO  - 10.1039/c4fo01135j
SP  - 1900
EP  - 1910
ER  - 

@article{
author = "Glamočlija, Jasmina and Stojković, Dejan and Nikolić, Miloš and Ćirić, Ana and Reis, Filipa S. and Barros, Lillian and Ferreira, Isabel C. F. R. and Soković, Marina",
year = "2015",
abstract = "Agaricus bisporus is a cultivated mushroom; A. bitorquis, A. campestris
   and A. macrosporus are edible mushrooms growing wild in nature. A
   chemical characterization was carried out with samples that originated
   in Serbia. Antioxidant, antimicrobial and anti-quorum sensing properties
   of their methanolic and ethanolic extracts were assessed. A. campestris
   had the lowest caloric value and total sugar content and showed the
   highest concentration in organic and phenolic acids, as also in
   tocopherols (mainly gamma-tocopherol). In general, the methanolic
   extracts showed higher antioxidant, but lower antibacterial and
   antifungal potential than ethanolic ones. Sub-inhibitory concentrations
   of the ethanolic extracts demonstrated reduction of virulence factors,
   AQ inhibition zones, twitching and swimming motility. The biofilm
   forming capability of P. aeruginosa PAO1 was also reduced in a
   concentration-dependent manner at sub-MIC values. The extracts of the
   tested Agaricus species are a promising source of antioxidant,
   antimicrobial and antiquorum sensing compounds.",
journal = "Food & Function",
title = "A comparative study on edible Agaricus mushrooms as functional foods",
number = "6",
volume = "6",
doi = "10.1039/c4fo01135j",
pages = "1900-1910"
}

Glamočlija, J., Stojković, D., Nikolić, M., Ćirić, A., Reis, F. S., Barros, L., Ferreira, I. C. F. R.,& Soković, M.. (2015). A comparative study on edible Agaricus mushrooms as functional foods. in Food & Function, 6(6), 1900-1910.
https://doi.org/10.1039/c4fo01135j

Glamočlija J, Stojković D, Nikolić M, Ćirić A, Reis FS, Barros L, Ferreira ICFR, Soković M. A comparative study on edible Agaricus mushrooms as functional foods. in Food & Function. 2015;6(6):1900-1910.
doi:10.1039/c4fo01135j .

Glamočlija, Jasmina, Stojković, Dejan, Nikolić, Miloš, Ćirić, Ana, Reis, Filipa S., Barros, Lillian, Ferreira, Isabel C. F. R., Soković, Marina, "A comparative study on edible Agaricus mushrooms as functional foods" in Food & Function, 6, no. 6 (2015):1900-1910,
https://doi.org/10.1039/c4fo01135j . .

TY  - JOUR
AU  - Popovic, Visnja
AU  - Stojković, Dejan
AU  - Nikolić, Miloš
AU  - Heyerick, Arne
AU  - Petrovic, Silvana
AU  - Soković, Marina
AU  - Niketic, Marjan
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2068
AB  - Antimicrobial properties of extracts of underground parts of three
   Laserpitium L. (Apiaceae) species, namely Laserpitium latifolium L.,
   Laserpitium zernyi Hayek and Laserpitium ochridanum Micevski, were
   investigated. The investigated species are widely used as functional
   foods, as spices and for preparations in traditional medicine for
   treating complaints connected with infection and inflammation.
   Furthermore, antimicrobial and antibiofilm effects of laserpitine, the
   most abundant compound in the chloroform extract of Laserpitium
   latifolium, and guaianolide sesquiterpene lactones, such as,
   isomontanolide, montanolide and tarolide, principal components of the
   extracts of Laserpitium zernyi and Laserpitium ochridanum were assessed.
   The antimicrobial activity was tested using the microdilution method
   against five pathogenic bacteria and five fungi, as well as in the
   microplate biofilm assay on two Candida clinical isolates (C. albicans
   and C. krusei). Among the extracts, Laserpitium latifolium showed the
   most prominent activity. Isolated metabolites exerted higher effects
   against fungal than against bacterial strains, isomontanolide being the
   most active. Interestingly, all constituents showed higher potential on
   inhibition of biofilm formation than fluconazole, a reference compound.
   Tested metabolites may be good novel agents with high antifungal and
   antibacterial potential that might find practical applications in food
   industry as food preservatives in order to retard the growth of food
   spoiling microbes, but only after detailed safety assessments.
T2  - Food & Function
T1  - Extracts of three Laserpitium L. species and their principal components
 laserpitine and sesquiterpene lactones inhibit microbial growth and
 biofilm formation by oral Candida isolates
IS  - 4
VL  - 6
DO  - 10.1039/c5fo00066a
SP  - 1205
EP  - 1211
ER  - 

@article{
author = "Popovic, Visnja and Stojković, Dejan and Nikolić, Miloš and Heyerick, Arne and Petrovic, Silvana and Soković, Marina and Niketic, Marjan",
year = "2015",
abstract = "Antimicrobial properties of extracts of underground parts of three
   Laserpitium L. (Apiaceae) species, namely Laserpitium latifolium L.,
   Laserpitium zernyi Hayek and Laserpitium ochridanum Micevski, were
   investigated. The investigated species are widely used as functional
   foods, as spices and for preparations in traditional medicine for
   treating complaints connected with infection and inflammation.
   Furthermore, antimicrobial and antibiofilm effects of laserpitine, the
   most abundant compound in the chloroform extract of Laserpitium
   latifolium, and guaianolide sesquiterpene lactones, such as,
   isomontanolide, montanolide and tarolide, principal components of the
   extracts of Laserpitium zernyi and Laserpitium ochridanum were assessed.
   The antimicrobial activity was tested using the microdilution method
   against five pathogenic bacteria and five fungi, as well as in the
   microplate biofilm assay on two Candida clinical isolates (C. albicans
   and C. krusei). Among the extracts, Laserpitium latifolium showed the
   most prominent activity. Isolated metabolites exerted higher effects
   against fungal than against bacterial strains, isomontanolide being the
   most active. Interestingly, all constituents showed higher potential on
   inhibition of biofilm formation than fluconazole, a reference compound.
   Tested metabolites may be good novel agents with high antifungal and
   antibacterial potential that might find practical applications in food
   industry as food preservatives in order to retard the growth of food
   spoiling microbes, but only after detailed safety assessments.",
journal = "Food & Function",
title = "Extracts of three Laserpitium L. species and their principal components
 laserpitine and sesquiterpene lactones inhibit microbial growth and
 biofilm formation by oral Candida isolates",
number = "4",
volume = "6",
doi = "10.1039/c5fo00066a",
pages = "1205-1211"
}

Popovic, V., Stojković, D., Nikolić, M., Heyerick, A., Petrovic, S., Soković, M.,& Niketic, M.. (2015). Extracts of three Laserpitium L. species and their principal components
 laserpitine and sesquiterpene lactones inhibit microbial growth and
 biofilm formation by oral Candida isolates. in Food & Function, 6(4), 1205-1211.
https://doi.org/10.1039/c5fo00066a

Popovic V, Stojković D, Nikolić M, Heyerick A, Petrovic S, Soković M, Niketic M. Extracts of three Laserpitium L. species and their principal components
 laserpitine and sesquiterpene lactones inhibit microbial growth and
 biofilm formation by oral Candida isolates. in Food & Function. 2015;6(4):1205-1211.
doi:10.1039/c5fo00066a .

Popovic, Visnja, Stojković, Dejan, Nikolić, Miloš, Heyerick, Arne, Petrovic, Silvana, Soković, Marina, Niketic, Marjan, "Extracts of three Laserpitium L. species and their principal components
 laserpitine and sesquiterpene lactones inhibit microbial growth and
 biofilm formation by oral Candida isolates" in Food & Function, 6, no. 4 (2015):1205-1211,
https://doi.org/10.1039/c5fo00066a . .

TY  - JOUR
AU  - Soković, Marina
AU  - Ćirić, Ana
AU  - Glamočlija, Jasmina
AU  - Nikolić, Miloš
AU  - van Griensven, Leo J. L. D.
PY  - 2014
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2225
AB  - The edible mushroom Agaricus blazei Murill is known to induce protective
   immunomodulatory action against a variety of infectious diseases. In the
   present study we report potential anti-quorum sensing properties of A.
   blazei hot water extract. Quorum sensing (QS) plays an important role in
   virulence, biofilm formation and survival of many pathogenic bacteria,
   including the Gram negative Pseudomonas aeruginosa, and is considered as
   a novel and promising target for anti-infectious agents. In this study,
   the effect of the sub-MICs of Agaricus blazei water extract on QS
   regulated virulence factors and biofilm formation was evaluated against
   P. aeruginosa PAO1. Sub-MIC concentrations of the extract which did not
   kill P. aeruginosa nor inhibited its growth, demonstrated a
   statistically significant reduction of virulence factors of P.
   aeruginosa, such as pyocyanin production, twitching and swimming
   motility. The biofilm forming capability of P. aeruginosa was also
   reduced in a concentration-dependent manner at sub-MIC values. Water
   extract of A. blazei is a promising source of antiquorum sensing and
   antibacterial compounds.
T2  - Molecules
T1  - Agaricus Blazei Hot Water Extract Shows Anti Quorum Sensing Activity in
 the Nosocomial Human Pathogen Pseudomonas Aeruginosa
IS  - 4
VL  - 19
DO  - 10.3390/molecules19044189
SP  - 4189
EP  - 4199
ER  - 

@article{
author = "Soković, Marina and Ćirić, Ana and Glamočlija, Jasmina and Nikolić, Miloš and van Griensven, Leo J. L. D.",
year = "2014",
abstract = "The edible mushroom Agaricus blazei Murill is known to induce protective
   immunomodulatory action against a variety of infectious diseases. In the
   present study we report potential anti-quorum sensing properties of A.
   blazei hot water extract. Quorum sensing (QS) plays an important role in
   virulence, biofilm formation and survival of many pathogenic bacteria,
   including the Gram negative Pseudomonas aeruginosa, and is considered as
   a novel and promising target for anti-infectious agents. In this study,
   the effect of the sub-MICs of Agaricus blazei water extract on QS
   regulated virulence factors and biofilm formation was evaluated against
   P. aeruginosa PAO1. Sub-MIC concentrations of the extract which did not
   kill P. aeruginosa nor inhibited its growth, demonstrated a
   statistically significant reduction of virulence factors of P.
   aeruginosa, such as pyocyanin production, twitching and swimming
   motility. The biofilm forming capability of P. aeruginosa was also
   reduced in a concentration-dependent manner at sub-MIC values. Water
   extract of A. blazei is a promising source of antiquorum sensing and
   antibacterial compounds.",
journal = "Molecules",
title = "Agaricus Blazei Hot Water Extract Shows Anti Quorum Sensing Activity in
 the Nosocomial Human Pathogen Pseudomonas Aeruginosa",
number = "4",
volume = "19",
doi = "10.3390/molecules19044189",
pages = "4189-4199"
}

Soković, M., Ćirić, A., Glamočlija, J., Nikolić, M.,& van Griensven, L. J. L. D.. (2014). Agaricus Blazei Hot Water Extract Shows Anti Quorum Sensing Activity in
 the Nosocomial Human Pathogen Pseudomonas Aeruginosa. in Molecules, 19(4), 4189-4199.
https://doi.org/10.3390/molecules19044189

Soković M, Ćirić A, Glamočlija J, Nikolić M, van Griensven LJLD. Agaricus Blazei Hot Water Extract Shows Anti Quorum Sensing Activity in
 the Nosocomial Human Pathogen Pseudomonas Aeruginosa. in Molecules. 2014;19(4):4189-4199.
doi:10.3390/molecules19044189 .

Soković, Marina, Ćirić, Ana, Glamočlija, Jasmina, Nikolić, Miloš, van Griensven, Leo J. L. D., "Agaricus Blazei Hot Water Extract Shows Anti Quorum Sensing Activity in
 the Nosocomial Human Pathogen Pseudomonas Aeruginosa" in Molecules, 19, no. 4 (2014):4189-4199,
https://doi.org/10.3390/molecules19044189 . .

TY  - JOUR
AU  - Nikolić, Miloš
AU  - Glamočlija, Jasmina
AU  - Ferreira, Isabel C. F. R.
AU  - Calhelha, Ricardo C.
AU  - Fernandes, Angela
AU  - Markovic, Tatjana
AU  - Markovic, Dejan
AU  - Giweli, Abdulhamed
AU  - Soković, Marina
PY  - 2014
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2300
AB  - Aromatic plant species of genus Thymus are important medicinal plants,
   highly recommended due to a range of therapeutic properties of their
   essential oils, commonly known as thyme oil: antirheumatic, antiseptic,
   antispasmodic, antimicrobial, cardiac, carminative, diuretic and
   expectorant. The oil is also beneficial in boosting the immune system
   and helps to fight colds, flu, infectious diseases and chills. It is
   proved to be a urinary antiseptic, being very helpful for cystitis and
   urethritis. Scientific validation of traditional uses, and phytochemical
   and bioactivity evaluation of essential oils from Thymus serpyllum,
   Thymus algeriensis and Thymus vulgaris were performed.
   GC/MS analysis revealed thymol as a major component of T. algeriensis,
   T. vulgaris and T. serpyllum, with its contribution to the oil 56.0\%,
   48.9\% and 38.5\%, respectively. All three essential oils (EOs)
   exhibited a significant antimicrobial activity against all tested
   strains, the T. serpyllum oil being the most potent one (MIC 2.5-5 mu
   g/mL, MBC 5-10 mu g/mL; MIC 1-2 mu g/mL, MFC 2-4 mu g/mL). In addition,
   the T. serpyllum oil revealed the highest antioxidant activity in all
   conducted assays and it was the most effective one against all tested
   cell lines, presenting GI(50) values of 7.02-52.69 mu g/mL. Moreover,
   none of the EOs showed toxicity at tested concentrations (>400 mu g/mL)
   for porcine liver primary cell culture. In addition to their well-known
   traditional use in food and cosmetics, the great potential of tested
   Thymus essential oils for application in oral diseases and anticancer
   treatments, encourage further investigation. (C) 2013 Elsevier B.V. All
   rights reserved.
T2  - Industrial Crops and Products
T1  - Chemical composition, antimicrobial, antioxidant and antitumor activity
 of Thymus serpyllum L., Thymus algeriensis Boiss. and Reut and Thymus
 vulgaris L. essential oils
VL  - 52
DO  - 10.1016/j.indcrop.2013.10.006
SP  - 183
EP  - 190
ER  - 

@article{
author = "Nikolić, Miloš and Glamočlija, Jasmina and Ferreira, Isabel C. F. R. and Calhelha, Ricardo C. and Fernandes, Angela and Markovic, Tatjana and Markovic, Dejan and Giweli, Abdulhamed and Soković, Marina",
year = "2014",
abstract = "Aromatic plant species of genus Thymus are important medicinal plants,
   highly recommended due to a range of therapeutic properties of their
   essential oils, commonly known as thyme oil: antirheumatic, antiseptic,
   antispasmodic, antimicrobial, cardiac, carminative, diuretic and
   expectorant. The oil is also beneficial in boosting the immune system
   and helps to fight colds, flu, infectious diseases and chills. It is
   proved to be a urinary antiseptic, being very helpful for cystitis and
   urethritis. Scientific validation of traditional uses, and phytochemical
   and bioactivity evaluation of essential oils from Thymus serpyllum,
   Thymus algeriensis and Thymus vulgaris were performed.
   GC/MS analysis revealed thymol as a major component of T. algeriensis,
   T. vulgaris and T. serpyllum, with its contribution to the oil 56.0\%,
   48.9\% and 38.5\%, respectively. All three essential oils (EOs)
   exhibited a significant antimicrobial activity against all tested
   strains, the T. serpyllum oil being the most potent one (MIC 2.5-5 mu
   g/mL, MBC 5-10 mu g/mL; MIC 1-2 mu g/mL, MFC 2-4 mu g/mL). In addition,
   the T. serpyllum oil revealed the highest antioxidant activity in all
   conducted assays and it was the most effective one against all tested
   cell lines, presenting GI(50) values of 7.02-52.69 mu g/mL. Moreover,
   none of the EOs showed toxicity at tested concentrations (>400 mu g/mL)
   for porcine liver primary cell culture. In addition to their well-known
   traditional use in food and cosmetics, the great potential of tested
   Thymus essential oils for application in oral diseases and anticancer
   treatments, encourage further investigation. (C) 2013 Elsevier B.V. All
   rights reserved.",
journal = "Industrial Crops and Products",
title = "Chemical composition, antimicrobial, antioxidant and antitumor activity
 of Thymus serpyllum L., Thymus algeriensis Boiss. and Reut and Thymus
 vulgaris L. essential oils",
volume = "52",
doi = "10.1016/j.indcrop.2013.10.006",
pages = "183-190"
}

Nikolić, M., Glamočlija, J., Ferreira, I. C. F. R., Calhelha, R. C., Fernandes, A., Markovic, T., Markovic, D., Giweli, A.,& Soković, M.. (2014). Chemical composition, antimicrobial, antioxidant and antitumor activity
 of Thymus serpyllum L., Thymus algeriensis Boiss. and Reut and Thymus
 vulgaris L. essential oils. in Industrial Crops and Products, 52, 183-190.
https://doi.org/10.1016/j.indcrop.2013.10.006

Nikolić M, Glamočlija J, Ferreira ICFR, Calhelha RC, Fernandes A, Markovic T, Markovic D, Giweli A, Soković M. Chemical composition, antimicrobial, antioxidant and antitumor activity
 of Thymus serpyllum L., Thymus algeriensis Boiss. and Reut and Thymus
 vulgaris L. essential oils. in Industrial Crops and Products. 2014;52:183-190.
doi:10.1016/j.indcrop.2013.10.006 .

Nikolić, Miloš, Glamočlija, Jasmina, Ferreira, Isabel C. F. R., Calhelha, Ricardo C., Fernandes, Angela, Markovic, Tatjana, Markovic, Dejan, Giweli, Abdulhamed, Soković, Marina, "Chemical composition, antimicrobial, antioxidant and antitumor activity
 of Thymus serpyllum L., Thymus algeriensis Boiss. and Reut and Thymus
 vulgaris L. essential oils" in Industrial Crops and Products, 52 (2014):183-190,
https://doi.org/10.1016/j.indcrop.2013.10.006 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Talevski, Aleksandra
AU  - Ćirić, Ana
AU  - Glamočlija, Jasmina
AU  - Nikolić, Miloš
AU  - Talevski, Trajce
AU  - Soković, Marina
PY  - 2014
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2280
AB  - The antimicrobial activity of five crude extracts (aqueous, methanol,
   ethyl acetate, acetone and methylene chloride) of the freshwater sponge
   Ochridaspongia rotunda (Arndt, 1937) was evaluated in vitro by using
   microdilution method against eight bacterial and eight fungal strains
   for the first time. The extracts were proven to be active in varying
   degrees against all the bacteria and fungi tested. O. rotunda methanol
   extract exhibited the highest antibacterial activity (minimum inhibitory
   concentration (MIC) 7.5-15.0 mu g/mL and minimum bactericidal
   concentration 15-30 mu g/mL), while its acetone extract exhibited the
   most promising antifungal activity (MIC 7.5-45.0 mu g/mL and minimum
   fungicidal concentration 15-60 mu g/mL). The extracts were more
   effective against the bacteria and fungi screened compared with the
   positive controls (streptomycin and ampicillin for bacteria and
   bifonazole and ketoconazole for fungi, respectively). According to the
   experimental data obtained, this deepwater sponge species may be
   considered as a gold mine of new antimicrobial substances with
   significant and broad-range activity.
T2  - Natural Product Research
T1  - In vitro evaluation of antimicrobial activity of the freshwater sponge
 Ochridaspongia rotunda (Arndt, 1937)
IS  - 18
VL  - 28
DO  - 10.1080/14786419.2014.911297
SP  - 1489
EP  - 1494
ER  - 

@article{
author = "Pejin, Boris and Talevski, Aleksandra and Ćirić, Ana and Glamočlija, Jasmina and Nikolić, Miloš and Talevski, Trajce and Soković, Marina",
year = "2014",
abstract = "The antimicrobial activity of five crude extracts (aqueous, methanol,
   ethyl acetate, acetone and methylene chloride) of the freshwater sponge
   Ochridaspongia rotunda (Arndt, 1937) was evaluated in vitro by using
   microdilution method against eight bacterial and eight fungal strains
   for the first time. The extracts were proven to be active in varying
   degrees against all the bacteria and fungi tested. O. rotunda methanol
   extract exhibited the highest antibacterial activity (minimum inhibitory
   concentration (MIC) 7.5-15.0 mu g/mL and minimum bactericidal
   concentration 15-30 mu g/mL), while its acetone extract exhibited the
   most promising antifungal activity (MIC 7.5-45.0 mu g/mL and minimum
   fungicidal concentration 15-60 mu g/mL). The extracts were more
   effective against the bacteria and fungi screened compared with the
   positive controls (streptomycin and ampicillin for bacteria and
   bifonazole and ketoconazole for fungi, respectively). According to the
   experimental data obtained, this deepwater sponge species may be
   considered as a gold mine of new antimicrobial substances with
   significant and broad-range activity.",
journal = "Natural Product Research",
title = "In vitro evaluation of antimicrobial activity of the freshwater sponge
 Ochridaspongia rotunda (Arndt, 1937)",
number = "18",
volume = "28",
doi = "10.1080/14786419.2014.911297",
pages = "1489-1494"
}

Pejin, B., Talevski, A., Ćirić, A., Glamočlija, J., Nikolić, M., Talevski, T.,& Soković, M.. (2014). In vitro evaluation of antimicrobial activity of the freshwater sponge
 Ochridaspongia rotunda (Arndt, 1937). in Natural Product Research, 28(18), 1489-1494.
https://doi.org/10.1080/14786419.2014.911297

Pejin B, Talevski A, Ćirić A, Glamočlija J, Nikolić M, Talevski T, Soković M. In vitro evaluation of antimicrobial activity of the freshwater sponge
 Ochridaspongia rotunda (Arndt, 1937). in Natural Product Research. 2014;28(18):1489-1494.
doi:10.1080/14786419.2014.911297 .

Pejin, Boris, Talevski, Aleksandra, Ćirić, Ana, Glamočlija, Jasmina, Nikolić, Miloš, Talevski, Trajce, Soković, Marina, "In vitro evaluation of antimicrobial activity of the freshwater sponge
 Ochridaspongia rotunda (Arndt, 1937)" in Natural Product Research, 28, no. 18 (2014):1489-1494,
https://doi.org/10.1080/14786419.2014.911297 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Iodice, Carmine
AU  - Tommonaro, Giuseppina
AU  - Stanimirovic, Bojana
AU  - Ćirić, Ana
AU  - Glamočlija, Jasmina
AU  - Nikolić, Miloš
AU  - De Rosa, Salvatore
AU  - Soković, Marina
PY  - 2014
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2276
AB  - This work extends in vitro screening of antimicrobial activity of the
   sesquiterpene hydroquinone avarol, a main secondary metabolite of the
   Mediterranean sponge species Dysidea avara. The antimicrobial activity
   was in part evaluated by microdilution method against selected bacterial
   and fungal strains. Additionally, the screening included evaluation of
   anti-quorum sensing (anti-QS) effects. At a different extent avarol was
   proven to be active against all the microorganisms tested (MIC
   0.002-0.008 mg/mL and MBC 0.004-0.016 mg/mL; MIC 0.004-0.015 mg/mL and
   MFC 0.008-0.030 mg/mL; respectively). This marine natural product also
   showed moderate anti-QS effects, reducing Pseudomonas aeruginosa PAO1
   biofilm formation (75\%), its twitching and protrusions motilities as
   well as pyocianin production (39\%). According to the best of our
   knowledge, this is the first report both on avarol anti Gram-negative
   bacterial activity and anti-QS effects.
T2  - Current Pharmaceutical Biotechnology
T1  - Further in vitro Evaluation of Antimicrobial Activity of the Marine
 Sesquiterpene Hydroquinone Avarol
IS  - 6
VL  - 15
SP  - 583
EP  - 588
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_2276
ER  - 

@article{
author = "Pejin, Boris and Iodice, Carmine and Tommonaro, Giuseppina and Stanimirovic, Bojana and Ćirić, Ana and Glamočlija, Jasmina and Nikolić, Miloš and De Rosa, Salvatore and Soković, Marina",
year = "2014",
abstract = "This work extends in vitro screening of antimicrobial activity of the
   sesquiterpene hydroquinone avarol, a main secondary metabolite of the
   Mediterranean sponge species Dysidea avara. The antimicrobial activity
   was in part evaluated by microdilution method against selected bacterial
   and fungal strains. Additionally, the screening included evaluation of
   anti-quorum sensing (anti-QS) effects. At a different extent avarol was
   proven to be active against all the microorganisms tested (MIC
   0.002-0.008 mg/mL and MBC 0.004-0.016 mg/mL; MIC 0.004-0.015 mg/mL and
   MFC 0.008-0.030 mg/mL; respectively). This marine natural product also
   showed moderate anti-QS effects, reducing Pseudomonas aeruginosa PAO1
   biofilm formation (75\%), its twitching and protrusions motilities as
   well as pyocianin production (39\%). According to the best of our
   knowledge, this is the first report both on avarol anti Gram-negative
   bacterial activity and anti-QS effects.",
journal = "Current Pharmaceutical Biotechnology",
title = "Further in vitro Evaluation of Antimicrobial Activity of the Marine
 Sesquiterpene Hydroquinone Avarol",
number = "6",
volume = "15",
pages = "583-588",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_2276"
}

Pejin, B., Iodice, C., Tommonaro, G., Stanimirovic, B., Ćirić, A., Glamočlija, J., Nikolić, M., De Rosa, S.,& Soković, M.. (2014). Further in vitro Evaluation of Antimicrobial Activity of the Marine
 Sesquiterpene Hydroquinone Avarol. in Current Pharmaceutical Biotechnology, 15(6), 583-588.
https://hdl.handle.net/21.15107/rcub_ibiss_2276

Pejin B, Iodice C, Tommonaro G, Stanimirovic B, Ćirić A, Glamočlija J, Nikolić M, De Rosa S, Soković M. Further in vitro Evaluation of Antimicrobial Activity of the Marine
 Sesquiterpene Hydroquinone Avarol. in Current Pharmaceutical Biotechnology. 2014;15(6):583-588.
https://hdl.handle.net/21.15107/rcub_ibiss_2276 .

Pejin, Boris, Iodice, Carmine, Tommonaro, Giuseppina, Stanimirovic, Bojana, Ćirić, Ana, Glamočlija, Jasmina, Nikolić, Miloš, De Rosa, Salvatore, Soković, Marina, "Further in vitro Evaluation of Antimicrobial Activity of the Marine
 Sesquiterpene Hydroquinone Avarol" in Current Pharmaceutical Biotechnology, 15, no. 6 (2014):583-588,
https://hdl.handle.net/21.15107/rcub_ibiss_2276 .

TY  - JOUR
AU  - Pejin, Boris
AU  - Talevska, Aleksandra
AU  - Ćirić, Ana
AU  - Glamočlija, Jasmina
AU  - Nikolić, Miloš
AU  - Talevski, Trajce
AU  - Soković, Marina
PY  - 2014
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2274
AB  - The anti-quorum sensing activities towards the bacterium Pseudomonas
   aeruginosa PA01 (pyocyanin production, biofilm formation and twitching
   and flagella motility) of two crude extracts (methanol and acetone) of
   the freshwater sponge Ochridaspongia rotunda (Arndt, 1937) were
   evaluated in vitro for the first time. Both extracts demonstrated P.
   aeruginosa pyocyanin inhibitory activity, reducing its production for
   49.90\% and 42.44\%, respectively. In addition, they both showed higher
   anti-biofilm activity (48.29\% and 53.99\%, respectively) than
   ampicillin (30.84\%). Finally, O. rotunda extracts effectively reduced
   twitching and flagella motility of P. aeruginosa. Taken all together,
   these results suggest that endemic sponge species from the oldest lake
   in Europe may offer novel bioactive natural products with promising
   medicinal potential towards P. aeruginosa infections.
T2  - Natural Product Research
T1  - Anti-quorum sensing activity of selected sponge extracts: a case study
 of Pseudomonas aeruginosa
IS  - 24
VL  - 28
DO  - 10.1080/14786419.2014.934239
SP  - 2330
EP  - 2333
ER  - 

@article{
author = "Pejin, Boris and Talevska, Aleksandra and Ćirić, Ana and Glamočlija, Jasmina and Nikolić, Miloš and Talevski, Trajce and Soković, Marina",
year = "2014",
abstract = "The anti-quorum sensing activities towards the bacterium Pseudomonas
   aeruginosa PA01 (pyocyanin production, biofilm formation and twitching
   and flagella motility) of two crude extracts (methanol and acetone) of
   the freshwater sponge Ochridaspongia rotunda (Arndt, 1937) were
   evaluated in vitro for the first time. Both extracts demonstrated P.
   aeruginosa pyocyanin inhibitory activity, reducing its production for
   49.90\% and 42.44\%, respectively. In addition, they both showed higher
   anti-biofilm activity (48.29\% and 53.99\%, respectively) than
   ampicillin (30.84\%). Finally, O. rotunda extracts effectively reduced
   twitching and flagella motility of P. aeruginosa. Taken all together,
   these results suggest that endemic sponge species from the oldest lake
   in Europe may offer novel bioactive natural products with promising
   medicinal potential towards P. aeruginosa infections.",
journal = "Natural Product Research",
title = "Anti-quorum sensing activity of selected sponge extracts: a case study
 of Pseudomonas aeruginosa",
number = "24",
volume = "28",
doi = "10.1080/14786419.2014.934239",
pages = "2330-2333"
}

Pejin, B., Talevska, A., Ćirić, A., Glamočlija, J., Nikolić, M., Talevski, T.,& Soković, M.. (2014). Anti-quorum sensing activity of selected sponge extracts: a case study
 of Pseudomonas aeruginosa. in Natural Product Research, 28(24), 2330-2333.
https://doi.org/10.1080/14786419.2014.934239

Pejin B, Talevska A, Ćirić A, Glamočlija J, Nikolić M, Talevski T, Soković M. Anti-quorum sensing activity of selected sponge extracts: a case study
 of Pseudomonas aeruginosa. in Natural Product Research. 2014;28(24):2330-2333.
doi:10.1080/14786419.2014.934239 .

Pejin, Boris, Talevska, Aleksandra, Ćirić, Ana, Glamočlija, Jasmina, Nikolić, Miloš, Talevski, Trajce, Soković, Marina, "Anti-quorum sensing activity of selected sponge extracts: a case study
 of Pseudomonas aeruginosa" in Natural Product Research, 28, no. 24 (2014):2330-2333,
https://doi.org/10.1080/14786419.2014.934239 . .

TY  - JOUR
AU  - Petrović, Jovana
AU  - Glamočlija, Jasmina
AU  - Stojković, Dejan
AU  - Nikolić, Miloš
AU  - Ćirić, Ana
AU  - Fernandes, Angela
AU  - Ferreira, Isabel C. F. R.
AU  - Soković, Marina
PY  - 2014
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2267
AB  - Agrocybe aegerita (Brig.) Sing is a basidiomycete, white rot fungus.
   Antimicrobial activities and the antiqourum effect on Pseudomonas
   aeruginosa of an A. aegerita methanolic extract were investigated. The
   extract showed very good antimicrobial activity against all the tested
   microorganisms in a dose dependent manner. Effects of the Sub-MIC, MIC
   and 2MIC of the A. aegerita methanolic extract regulated the virulence
   factors in the quorum sensing (QS) test, as well as biofilm formation on
   P. aeruginosa. Sub-inhibitory and inhibitory concentrations of the
   extract demonstrated the reduction of virulence factors such as
   pyocyanin production, twitching and swimming motility. The biofilm
   forming capability of P. aeruginosa PAO1 was also reduced in a
   concentration-dependent manner. Furthermore, the chemical composition of
   the methanolic extract was determined considering its phenolic
   composition. The methanolic extract of A. aegerita can be a very good
   source of bioactive substances. This research is of great importance due
   to the prevalence of drug-resistant microorganisms.
T2  - Food & Function
T1  - Bioactive composition, antimicrobial activities and the influence of
 Agrocybe aegerita (Brig.) Sing on certain quorum-sensing-regulated
 functions and biofilm formation by Pseudomonas aeruginosa
IS  - 12
VL  - 5
DO  - 10.1039/c4fo00819g
SP  - 3296
EP  - 3303
ER  - 

@article{
author = "Petrović, Jovana and Glamočlija, Jasmina and Stojković, Dejan and Nikolić, Miloš and Ćirić, Ana and Fernandes, Angela and Ferreira, Isabel C. F. R. and Soković, Marina",
year = "2014",
abstract = "Agrocybe aegerita (Brig.) Sing is a basidiomycete, white rot fungus.
   Antimicrobial activities and the antiqourum effect on Pseudomonas
   aeruginosa of an A. aegerita methanolic extract were investigated. The
   extract showed very good antimicrobial activity against all the tested
   microorganisms in a dose dependent manner. Effects of the Sub-MIC, MIC
   and 2MIC of the A. aegerita methanolic extract regulated the virulence
   factors in the quorum sensing (QS) test, as well as biofilm formation on
   P. aeruginosa. Sub-inhibitory and inhibitory concentrations of the
   extract demonstrated the reduction of virulence factors such as
   pyocyanin production, twitching and swimming motility. The biofilm
   forming capability of P. aeruginosa PAO1 was also reduced in a
   concentration-dependent manner. Furthermore, the chemical composition of
   the methanolic extract was determined considering its phenolic
   composition. The methanolic extract of A. aegerita can be a very good
   source of bioactive substances. This research is of great importance due
   to the prevalence of drug-resistant microorganisms.",
journal = "Food & Function",
title = "Bioactive composition, antimicrobial activities and the influence of
 Agrocybe aegerita (Brig.) Sing on certain quorum-sensing-regulated
 functions and biofilm formation by Pseudomonas aeruginosa",
number = "12",
volume = "5",
doi = "10.1039/c4fo00819g",
pages = "3296-3303"
}

Petrović, J., Glamočlija, J., Stojković, D., Nikolić, M., Ćirić, A., Fernandes, A., Ferreira, I. C. F. R.,& Soković, M.. (2014). Bioactive composition, antimicrobial activities and the influence of
 Agrocybe aegerita (Brig.) Sing on certain quorum-sensing-regulated
 functions and biofilm formation by Pseudomonas aeruginosa. in Food & Function, 5(12), 3296-3303.
https://doi.org/10.1039/c4fo00819g

Petrović J, Glamočlija J, Stojković D, Nikolić M, Ćirić A, Fernandes A, Ferreira ICFR, Soković M. Bioactive composition, antimicrobial activities and the influence of
 Agrocybe aegerita (Brig.) Sing on certain quorum-sensing-regulated
 functions and biofilm formation by Pseudomonas aeruginosa. in Food & Function. 2014;5(12):3296-3303.
doi:10.1039/c4fo00819g .

Petrović, Jovana, Glamočlija, Jasmina, Stojković, Dejan, Nikolić, Miloš, Ćirić, Ana, Fernandes, Angela, Ferreira, Isabel C. F. R., Soković, Marina, "Bioactive composition, antimicrobial activities and the influence of
 Agrocybe aegerita (Brig.) Sing on certain quorum-sensing-regulated
 functions and biofilm formation by Pseudomonas aeruginosa" in Food & Function, 5, no. 12 (2014):3296-3303,
https://doi.org/10.1039/c4fo00819g . .

TY  - JOUR
AU  - Nikolić, Miloš
AU  - Jovanovic, Katarina K.
AU  - Markovic, Tatjana
AU  - Markovic, Dejan
AU  - Gligorijevic, Nevenka
AU  - Radulovic, Sinia
AU  - Soković, Marina
PY  - 2014
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2134
AB  - The aim of this study was to assess the biological activity of essential
   oils from five Lamiaceae species, Mentha piperita, Mentha pulegium,
   Lavandula angustifolia, Satureja montana and Salvia lavandulifolia, for
   their chemical composition, antimicrobial and cytotoxic properties. Gas
   chromatography coupled with FID and MS of essential oils revealed
   menthol (47.5\%), pulegone (68.7), linalool (40.3\%), thymol (44.6\%),
   and camphor (29.1\%) to be major oils' components, respectively. Minimum
   inhibitory (MIC) and minimum bactericidal/fungicidal (MBC/MFC)
   concentrations were determined by microdilution method. Seven bacterial
   species, representing clinical specimens, including Streptococcus
   mutans, Streptococcus sanguis, Streptococcus salivarius, Streptococcus
   pyogenes, Pseudomonas aeruginosa, Lactobacillus acidophilus, and
   Enterecoccus feacalis, and fifty eight clinical oral Candida spp.
   isolates along with three reference strains were used in experiment. All
   essential oils (EOs) exhibited a significant antimicrobial activity
   against all tested microorganisms; the oil of S. montana proved to be
   the most potent one (MIC 30.0-630.0 mu g/mL, MBC 60.0-250.0 mu g/mL; MIC
   0.9-1.0 mu g/mL; MFC 1.0-3.0 mu g/mL). In addition, the oil also
   revealed the highest cytotoxic activity against tested cell lines,
   presenting IC50 values from 40.13 to 65.51 mu g/mL, with mild
   selectivity towards HeLa cells observed in regard to the normal cell
   line (MRC-5). In addition to the herbs traditional use in food and
   pharmacy, results of this study proved the great potential of their
   essential oils for application in oral disease and anticancer
   treatments. (C) 2014 Elsevier B.V. All rights reserved.
T2  - Industrial Crops and Products
T1  - Chemical composition, antimicrobial, and cytotoxic properties of five
 Lamiaceae essential oils
VL  - 61
DO  - 10.1016/j.indcrop.2014.07.011
SP  - 225
EP  - 232
ER  - 

@article{
author = "Nikolić, Miloš and Jovanovic, Katarina K. and Markovic, Tatjana and Markovic, Dejan and Gligorijevic, Nevenka and Radulovic, Sinia and Soković, Marina",
year = "2014",
abstract = "The aim of this study was to assess the biological activity of essential
   oils from five Lamiaceae species, Mentha piperita, Mentha pulegium,
   Lavandula angustifolia, Satureja montana and Salvia lavandulifolia, for
   their chemical composition, antimicrobial and cytotoxic properties. Gas
   chromatography coupled with FID and MS of essential oils revealed
   menthol (47.5\%), pulegone (68.7), linalool (40.3\%), thymol (44.6\%),
   and camphor (29.1\%) to be major oils' components, respectively. Minimum
   inhibitory (MIC) and minimum bactericidal/fungicidal (MBC/MFC)
   concentrations were determined by microdilution method. Seven bacterial
   species, representing clinical specimens, including Streptococcus
   mutans, Streptococcus sanguis, Streptococcus salivarius, Streptococcus
   pyogenes, Pseudomonas aeruginosa, Lactobacillus acidophilus, and
   Enterecoccus feacalis, and fifty eight clinical oral Candida spp.
   isolates along with three reference strains were used in experiment. All
   essential oils (EOs) exhibited a significant antimicrobial activity
   against all tested microorganisms; the oil of S. montana proved to be
   the most potent one (MIC 30.0-630.0 mu g/mL, MBC 60.0-250.0 mu g/mL; MIC
   0.9-1.0 mu g/mL; MFC 1.0-3.0 mu g/mL). In addition, the oil also
   revealed the highest cytotoxic activity against tested cell lines,
   presenting IC50 values from 40.13 to 65.51 mu g/mL, with mild
   selectivity towards HeLa cells observed in regard to the normal cell
   line (MRC-5). In addition to the herbs traditional use in food and
   pharmacy, results of this study proved the great potential of their
   essential oils for application in oral disease and anticancer
   treatments. (C) 2014 Elsevier B.V. All rights reserved.",
journal = "Industrial Crops and Products",
title = "Chemical composition, antimicrobial, and cytotoxic properties of five
 Lamiaceae essential oils",
volume = "61",
doi = "10.1016/j.indcrop.2014.07.011",
pages = "225-232"
}

Nikolić, M., Jovanovic, K. K., Markovic, T., Markovic, D., Gligorijevic, N., Radulovic, S.,& Soković, M.. (2014). Chemical composition, antimicrobial, and cytotoxic properties of five
 Lamiaceae essential oils. in Industrial Crops and Products, 61, 225-232.
https://doi.org/10.1016/j.indcrop.2014.07.011

Nikolić M, Jovanovic KK, Markovic T, Markovic D, Gligorijevic N, Radulovic S, Soković M. Chemical composition, antimicrobial, and cytotoxic properties of five
 Lamiaceae essential oils. in Industrial Crops and Products. 2014;61:225-232.
doi:10.1016/j.indcrop.2014.07.011 .

Nikolić, Miloš, Jovanovic, Katarina K., Markovic, Tatjana, Markovic, Dejan, Gligorijevic, Nevenka, Radulovic, Sinia, Soković, Marina, "Chemical composition, antimicrobial, and cytotoxic properties of five
 Lamiaceae essential oils" in Industrial Crops and Products, 61 (2014):225-232,
https://doi.org/10.1016/j.indcrop.2014.07.011 . .