TY  - JOUR
AU  - Žikić, Radoslav V.
AU  - Štajn, Andraš Š.
AU  - Ognjanović, Branka
AU  - Saičić, Zorica
AU  - Kostić, Milosav M.
AU  - Pavlović, Slađan
AU  - Petrović, Vojislav M.
PY  - 1998
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5898
AB  - Two month-old Wistar male albino rats were exposed during a 30-day period to a daily oral intake ad libitum of either 200 Fig/mL Cd (as CdClt), 0.1 Fig/ mL Se (as Na-selenite), or the same dosages of Cd + Se in drinking water. The daily intake from the water was calculated to be 15 mg Cd/kg and 7 kg Se/kg. Cadmium (Cd) accumulates in the heart p < 0.005) and, in rats, decreases both body mass growth p < 0.005) and heart mass (p < 0.02). Selenium (Se) significantly decreases the negative effect of Cd on body mass growth. In the hearts of Cd-treated rats, cadmium caused the decrease (p < 0.05) of selenium-dependent glutathione peroxidase (GSH-Px, EC 1.11.1.9) activity. At the same time, the activities of total superoxide dismutase (total SOD, EC 1.15.1. 1), manganese-containing superoxide dismutase (Mn SOD), and copper-zinc-containing superoxide dismutase (CuZn SOD) were increased (p < 0.005).
The activities of total SOD, CuZn SOD (p < 0.005), GSH-Px (p < 0.02), and glutathione-S-transferase (GST, p < 0.005) were increased in the hearts of Se- treated rats. However, by concomitant administration of Cd and Se, these changes were diminished (total SOD, GST) or were completely eliminated (Mn SOD, GSH-Px). These results indicate that Se only partly diminishes the effects of Cd cardiotoxicity.
PB  - Begell House, Inc.
T2  - Journal of Environmental Pathology, Toxicology and Oncology
T1  - The Effect of Cadmium and Selenium on the Antioxidant Enzyme Activities in Rat Heart
IS  - 3-4
VL  - 17
SP  - 259
EP  - 264
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5898
ER  - 

@article{
author = "Žikić, Radoslav V. and Štajn, Andraš Š. and Ognjanović, Branka and Saičić, Zorica and Kostić, Milosav M. and Pavlović, Slađan and Petrović, Vojislav M.",
year = "1998",
abstract = "Two month-old Wistar male albino rats were exposed during a 30-day period to a daily oral intake ad libitum of either 200 Fig/mL Cd (as CdClt), 0.1 Fig/ mL Se (as Na-selenite), or the same dosages of Cd + Se in drinking water. The daily intake from the water was calculated to be 15 mg Cd/kg and 7 kg Se/kg. Cadmium (Cd) accumulates in the heart p < 0.005) and, in rats, decreases both body mass growth p < 0.005) and heart mass (p < 0.02). Selenium (Se) significantly decreases the negative effect of Cd on body mass growth. In the hearts of Cd-treated rats, cadmium caused the decrease (p < 0.05) of selenium-dependent glutathione peroxidase (GSH-Px, EC 1.11.1.9) activity. At the same time, the activities of total superoxide dismutase (total SOD, EC 1.15.1. 1), manganese-containing superoxide dismutase (Mn SOD), and copper-zinc-containing superoxide dismutase (CuZn SOD) were increased (p < 0.005).
The activities of total SOD, CuZn SOD (p < 0.005), GSH-Px (p < 0.02), and glutathione-S-transferase (GST, p < 0.005) were increased in the hearts of Se- treated rats. However, by concomitant administration of Cd and Se, these changes were diminished (total SOD, GST) or were completely eliminated (Mn SOD, GSH-Px). These results indicate that Se only partly diminishes the effects of Cd cardiotoxicity.",
publisher = "Begell House, Inc.",
journal = "Journal of Environmental Pathology, Toxicology and Oncology",
title = "The Effect of Cadmium and Selenium on the Antioxidant Enzyme Activities in Rat Heart",
number = "3-4",
volume = "17",
pages = "259-264",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5898"
}

Žikić, R. V., Štajn, A. Š., Ognjanović, B., Saičić, Z., Kostić, M. M., Pavlović, S.,& Petrović, V. M.. (1998). The Effect of Cadmium and Selenium on the Antioxidant Enzyme Activities in Rat Heart. in Journal of Environmental Pathology, Toxicology and Oncology
Begell House, Inc.., 17(3-4), 259-264.
https://hdl.handle.net/21.15107/rcub_ibiss_5898

Žikić RV, Štajn AŠ, Ognjanović B, Saičić Z, Kostić MM, Pavlović S, Petrović VM. The Effect of Cadmium and Selenium on the Antioxidant Enzyme Activities in Rat Heart. in Journal of Environmental Pathology, Toxicology and Oncology. 1998;17(3-4):259-264.
https://hdl.handle.net/21.15107/rcub_ibiss_5898 .

Žikić, Radoslav V., Štajn, Andraš Š., Ognjanović, Branka, Saičić, Zorica, Kostić, Milosav M., Pavlović, Slađan, Petrović, Vojislav M., "The Effect of Cadmium and Selenium on the Antioxidant Enzyme Activities in Rat Heart" in Journal of Environmental Pathology, Toxicology and Oncology, 17, no. 3-4 (1998):259-264,
https://hdl.handle.net/21.15107/rcub_ibiss_5898 .