TY  - JOUR
AU  - Bensing, Christian
AU  - Mojić, Marija
AU  - Bulatović, Mirna
AU  - Edeler, David
AU  - Pérez-Quintanilla, Damian
AU  - Gómez-Ruiz, Santiago
AU  - Maksimović-Ivanić, Danijela
AU  - Mijatović, Sanja
AU  - Kaluđerović, Goran N.
PY  - 2022
UR  - https://linkinghub.elsevier.com/retrieve/pii/S2772950822003314
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5106
AB  - A series of nanostructured SBA-15-based materials functionalized with the tetraorganotin(IV) metallodrugs Ph3Sn(CH2)nOH (n = 3, 4, 6, 8 and 11) are synthesized and structurally characterized by different techniques used in solid-state chemistry. The cytotoxicity of both the organotin(IV) compounds and the tin-functionalized SBA-15 materials are studied against different cancer cell lines observing that the materials have similar cytotoxic activity in comparison with the free organotin compounds in terms of mass. However, considering that the percentage of active metal compound loaded into material is low, the utilization of mesoporous silica as drug vehicle clearly improves the cytotoxic effectiveness of metal-based drugs against cancer cells. One of the most potent between all tested systems is material SBA-15~Cl|Ph3Sn(CH2)8OH. Its cytotoxicity seems to come from additional mechanisms apart from apoptosis provoking cell reprogram in B16 melanoma into more mature and less aggressive phenotype. Moderated production of ROS/RNS is probably in the background of observed phenomenon. Obtained results are further confirmed in syngeneic mouse model of melanoma in C57BL6 mice. The in vivo results show that SBA-15 do not disturb tumor growth, while both Ph3Sn(CH2)8OH and SBA-15~Cl|Ph3Sn(CH2)8OH significantly decreases tumor volume with an enhancement of the antitumor potential of the tetraorganotin(IV) compound upon immobilization in SBA-15.
PB  - Elsevier B.V.
T2  - Biomaterials Advances
T1  - Effect of chain length on the cytotoxic activity of (alkyl-ω-ol)triphenyltin(IV) loaded into SBA-15 nanostructured silica and in vivo study of SBA-15~Cl|Ph3Sn(CH2)8OH.
VL  - 140
DO  - 10.1016/j.bioadv.2022.213054
SP  - 213054
ER  - 

@article{
author = "Bensing, Christian and Mojić, Marija and Bulatović, Mirna and Edeler, David and Pérez-Quintanilla, Damian and Gómez-Ruiz, Santiago and Maksimović-Ivanić, Danijela and Mijatović, Sanja and Kaluđerović, Goran N.",
year = "2022",
abstract = "A series of nanostructured SBA-15-based materials functionalized with the tetraorganotin(IV) metallodrugs Ph3Sn(CH2)nOH (n = 3, 4, 6, 8 and 11) are synthesized and structurally characterized by different techniques used in solid-state chemistry. The cytotoxicity of both the organotin(IV) compounds and the tin-functionalized SBA-15 materials are studied against different cancer cell lines observing that the materials have similar cytotoxic activity in comparison with the free organotin compounds in terms of mass. However, considering that the percentage of active metal compound loaded into material is low, the utilization of mesoporous silica as drug vehicle clearly improves the cytotoxic effectiveness of metal-based drugs against cancer cells. One of the most potent between all tested systems is material SBA-15~Cl|Ph3Sn(CH2)8OH. Its cytotoxicity seems to come from additional mechanisms apart from apoptosis provoking cell reprogram in B16 melanoma into more mature and less aggressive phenotype. Moderated production of ROS/RNS is probably in the background of observed phenomenon. Obtained results are further confirmed in syngeneic mouse model of melanoma in C57BL6 mice. The in vivo results show that SBA-15 do not disturb tumor growth, while both Ph3Sn(CH2)8OH and SBA-15~Cl|Ph3Sn(CH2)8OH significantly decreases tumor volume with an enhancement of the antitumor potential of the tetraorganotin(IV) compound upon immobilization in SBA-15.",
publisher = "Elsevier B.V.",
journal = "Biomaterials Advances",
title = "Effect of chain length on the cytotoxic activity of (alkyl-ω-ol)triphenyltin(IV) loaded into SBA-15 nanostructured silica and in vivo study of SBA-15~Cl|Ph3Sn(CH2)8OH.",
volume = "140",
doi = "10.1016/j.bioadv.2022.213054",
pages = "213054"
}

Bensing, C., Mojić, M., Bulatović, M., Edeler, D., Pérez-Quintanilla, D., Gómez-Ruiz, S., Maksimović-Ivanić, D., Mijatović, S.,& Kaluđerović, G. N.. (2022). Effect of chain length on the cytotoxic activity of (alkyl-ω-ol)triphenyltin(IV) loaded into SBA-15 nanostructured silica and in vivo study of SBA-15~Cl|Ph3Sn(CH2)8OH.. in Biomaterials Advances
Elsevier B.V.., 140, 213054.
https://doi.org/10.1016/j.bioadv.2022.213054

Bensing C, Mojić M, Bulatović M, Edeler D, Pérez-Quintanilla D, Gómez-Ruiz S, Maksimović-Ivanić D, Mijatović S, Kaluđerović GN. Effect of chain length on the cytotoxic activity of (alkyl-ω-ol)triphenyltin(IV) loaded into SBA-15 nanostructured silica and in vivo study of SBA-15~Cl|Ph3Sn(CH2)8OH.. in Biomaterials Advances. 2022;140:213054.
doi:10.1016/j.bioadv.2022.213054 .

Bensing, Christian, Mojić, Marija, Bulatović, Mirna, Edeler, David, Pérez-Quintanilla, Damian, Gómez-Ruiz, Santiago, Maksimović-Ivanić, Danijela, Mijatović, Sanja, Kaluđerović, Goran N., "Effect of chain length on the cytotoxic activity of (alkyl-ω-ol)triphenyltin(IV) loaded into SBA-15 nanostructured silica and in vivo study of SBA-15~Cl|Ph3Sn(CH2)8OH." in Biomaterials Advances, 140 (2022):213054,
https://doi.org/10.1016/j.bioadv.2022.213054 . .

TY  - JOUR
AU  - Maksimović-Ivanić, Danijela
AU  - Bulatović, Mirna
AU  - Edeler, David
AU  - Bensing, Christian
AU  - Golić, Igor
AU  - Korać, Aleksandra
AU  - Kaluđerović, Goran N.
AU  - Mijatović, Sanja
PY  - 2019
UR  - http://link.springer.com/10.1007/s00775-019-01640-x
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3276
AB  - Extraordinary progress in medicinal inorganic chemistry in the past few years led to the rational design of novel platinum compounds, as well as nonplatinum metal-based antitumor agents, including organotin compounds, whose activity is not based on unrepairable interaction with DNA. To overcome poor solubility and toxicity problems that limited the application of these compounds numerous delivering systems were used (Lila et al. in Biol Pharm Bull 37:206–211, 2014; Yue and Cao in Curr Cancer Drug Targets 16:480–488, 2016; Duan et al. in WIREs Nanomed Nanobiotechnol 8:776–791, 2016). Regarding high drug loading capacity, mesoporous silica nanoparticles like SBA-15 became more important for targeted drug delivery. In this study, cellular uptake and biological activities responsible for organotin(IV) compound Ph3Sn(CH2)6OH (Sn6) grafted into (3-chloropropyl)triethoxysilane functionalized SBA-15 (SBA-15p → SBA-15p|Sn6) were evaluated in human melanoma A375 cell line. Moreover, the influence of SBA-15p grafted with organotin(IV) compound on the stemness of A375 cell was tested. Given the fact that SBA-15p|Sn6 nanoparticles are nonspherical and relatively large, their internalization efficiently started even after 15 min with stable adhesion to the cell membrane. After only 2 h of incubation of A375 cells with SBA-15p|Sn6 passive fluid-phase uptake and macropinocytosis were observed. Inside of the cell, treatment with SBA-15p loaded with Sn6 promoted caspase-dependent apoptosis in parallel with senescence development. The subpopulation of cells expressing Schwann-like phenotype arose upon the treatment, while the signaling pathway responsible for maintenance of pluripotency and invasiveness, Wnt, Notch1, and Oct3/4 were modulated towards less aggressive signature. In summary, SBA-15p enhances the efficacy of free Sn6 compound through efficient uptake and well profiled intracellular response followed with decreased stem characteristics of highly invasive A375 melanoma cells.
T2  - JBIC Journal of Biological Inorganic Chemistry
T1  - The interaction between SBA-15 derivative loaded with Ph3Sn(CH2)6OH and human melanoma A375 cell line: uptake and stem phenotype loss
DO  - 10.1007/s00775-019-01640-x
ER  - 

@article{
author = "Maksimović-Ivanić, Danijela and Bulatović, Mirna and Edeler, David and Bensing, Christian and Golić, Igor and Korać, Aleksandra and Kaluđerović, Goran N. and Mijatović, Sanja",
year = "2019",
abstract = "Extraordinary progress in medicinal inorganic chemistry in the past few years led to the rational design of novel platinum compounds, as well as nonplatinum metal-based antitumor agents, including organotin compounds, whose activity is not based on unrepairable interaction with DNA. To overcome poor solubility and toxicity problems that limited the application of these compounds numerous delivering systems were used (Lila et al. in Biol Pharm Bull 37:206–211, 2014; Yue and Cao in Curr Cancer Drug Targets 16:480–488, 2016; Duan et al. in WIREs Nanomed Nanobiotechnol 8:776–791, 2016). Regarding high drug loading capacity, mesoporous silica nanoparticles like SBA-15 became more important for targeted drug delivery. In this study, cellular uptake and biological activities responsible for organotin(IV) compound Ph3Sn(CH2)6OH (Sn6) grafted into (3-chloropropyl)triethoxysilane functionalized SBA-15 (SBA-15p → SBA-15p|Sn6) were evaluated in human melanoma A375 cell line. Moreover, the influence of SBA-15p grafted with organotin(IV) compound on the stemness of A375 cell was tested. Given the fact that SBA-15p|Sn6 nanoparticles are nonspherical and relatively large, their internalization efficiently started even after 15 min with stable adhesion to the cell membrane. After only 2 h of incubation of A375 cells with SBA-15p|Sn6 passive fluid-phase uptake and macropinocytosis were observed. Inside of the cell, treatment with SBA-15p loaded with Sn6 promoted caspase-dependent apoptosis in parallel with senescence development. The subpopulation of cells expressing Schwann-like phenotype arose upon the treatment, while the signaling pathway responsible for maintenance of pluripotency and invasiveness, Wnt, Notch1, and Oct3/4 were modulated towards less aggressive signature. In summary, SBA-15p enhances the efficacy of free Sn6 compound through efficient uptake and well profiled intracellular response followed with decreased stem characteristics of highly invasive A375 melanoma cells.",
journal = "JBIC Journal of Biological Inorganic Chemistry",
title = "The interaction between SBA-15 derivative loaded with Ph3Sn(CH2)6OH and human melanoma A375 cell line: uptake and stem phenotype loss",
doi = "10.1007/s00775-019-01640-x"
}

Maksimović-Ivanić, D., Bulatović, M., Edeler, D., Bensing, C., Golić, I., Korać, A., Kaluđerović, G. N.,& Mijatović, S.. (2019). The interaction between SBA-15 derivative loaded with Ph3Sn(CH2)6OH and human melanoma A375 cell line: uptake and stem phenotype loss. in JBIC Journal of Biological Inorganic Chemistry.
https://doi.org/10.1007/s00775-019-01640-x

Maksimović-Ivanić D, Bulatović M, Edeler D, Bensing C, Golić I, Korać A, Kaluđerović GN, Mijatović S. The interaction between SBA-15 derivative loaded with Ph3Sn(CH2)6OH and human melanoma A375 cell line: uptake and stem phenotype loss. in JBIC Journal of Biological Inorganic Chemistry. 2019;.
doi:10.1007/s00775-019-01640-x .

Maksimović-Ivanić, Danijela, Bulatović, Mirna, Edeler, David, Bensing, Christian, Golić, Igor, Korać, Aleksandra, Kaluđerović, Goran N., Mijatović, Sanja, "The interaction between SBA-15 derivative loaded with Ph3Sn(CH2)6OH and human melanoma A375 cell line: uptake and stem phenotype loss" in JBIC Journal of Biological Inorganic Chemistry (2019),
https://doi.org/10.1007/s00775-019-01640-x . .

TY  - JOUR
AU  - Kaluđerović, Goran
AU  - Bulatović, Mirna
AU  - Krajnović, Tamara
AU  - Paschke, Reinhard
AU  - B. Zmejkovski, Bojana
AU  - Maksimović-Ivanić, Danijela
AU  - Mijatović, Sanja
PY  - 2017
UR  - http://www.mdpi.com/2304-6740/5/3/56
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3042
AB  - Synthesis of platinum(II) conjugate with acetylated betulinic acid tris(hydroxymethyl)aminomethane ester (BATRIS) is presented (BATRISPt). HR-ESI-MS and multinuclear NMR spectroscopy, as well as elemental analysis were used for characterization of BATRISPt. Cytotoxicity (3-(4,5-dimethythiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), crystal violet (CV), and sulforhodamine B (SRB) assays) of BA, BATRIS, BATRISPt, and cisplatin were assessed on seven different tumor cell lines: melanoma B16, colon HCT116 and DLD-1, adenocarcinoma HeLa, breast MCF-7, and anaplastic thyroid tumor 8505C and SW1736; as well as normal MRC-5 fibroblasts. Furthermore, the effect of the mentioned compounds on the apoptosis (Annexin V/PI assay) and autophagy induction (acridine orange (AO) assay) as well as caspase 3, 8, and 9 activation were investigated on the selected B16 melanoma cell line. BATRISPt showed lower activity than BA, BATRIS, or cisplatin. All tested compounds triggered apoptosis in B16 cells. Induction of autophagy was observed in B16 cells exposed only to BATRIS. On the other hand, new conjugate activates caspases 8 and 9 in B16 cells with higher impact than BATRIS or cisplatin alone.
T2  - Inorganics
T1  - (18-Crown-6)potassium(I) Trichlorido[28-acetyl-3-(tris-(hydroxylmethyl)amino-ethane)betulinic ester-κN]platinum(II): Synthesis and In Vitro Antitumor Activity
IS  - 3
VL  - 5
DO  - 10.3390/inorganics5030056
SP  - 56
ER  - 

@article{
author = "Kaluđerović, Goran and Bulatović, Mirna and Krajnović, Tamara and Paschke, Reinhard and B. Zmejkovski, Bojana and Maksimović-Ivanić, Danijela and Mijatović, Sanja",
year = "2017",
abstract = "Synthesis of platinum(II) conjugate with acetylated betulinic acid tris(hydroxymethyl)aminomethane ester (BATRIS) is presented (BATRISPt). HR-ESI-MS and multinuclear NMR spectroscopy, as well as elemental analysis were used for characterization of BATRISPt. Cytotoxicity (3-(4,5-dimethythiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), crystal violet (CV), and sulforhodamine B (SRB) assays) of BA, BATRIS, BATRISPt, and cisplatin were assessed on seven different tumor cell lines: melanoma B16, colon HCT116 and DLD-1, adenocarcinoma HeLa, breast MCF-7, and anaplastic thyroid tumor 8505C and SW1736; as well as normal MRC-5 fibroblasts. Furthermore, the effect of the mentioned compounds on the apoptosis (Annexin V/PI assay) and autophagy induction (acridine orange (AO) assay) as well as caspase 3, 8, and 9 activation were investigated on the selected B16 melanoma cell line. BATRISPt showed lower activity than BA, BATRIS, or cisplatin. All tested compounds triggered apoptosis in B16 cells. Induction of autophagy was observed in B16 cells exposed only to BATRIS. On the other hand, new conjugate activates caspases 8 and 9 in B16 cells with higher impact than BATRIS or cisplatin alone.",
journal = "Inorganics",
title = "(18-Crown-6)potassium(I) Trichlorido[28-acetyl-3-(tris-(hydroxylmethyl)amino-ethane)betulinic ester-κN]platinum(II): Synthesis and In Vitro Antitumor Activity",
number = "3",
volume = "5",
doi = "10.3390/inorganics5030056",
pages = "56"
}

Kaluđerović, G., Bulatović, M., Krajnović, T., Paschke, R., B. Zmejkovski, B., Maksimović-Ivanić, D.,& Mijatović, S.. (2017). (18-Crown-6)potassium(I) Trichlorido[28-acetyl-3-(tris-(hydroxylmethyl)amino-ethane)betulinic ester-κN]platinum(II): Synthesis and In Vitro Antitumor Activity. in Inorganics, 5(3), 56.
https://doi.org/10.3390/inorganics5030056

Kaluđerović G, Bulatović M, Krajnović T, Paschke R, B. Zmejkovski B, Maksimović-Ivanić D, Mijatović S. (18-Crown-6)potassium(I) Trichlorido[28-acetyl-3-(tris-(hydroxylmethyl)amino-ethane)betulinic ester-κN]platinum(II): Synthesis and In Vitro Antitumor Activity. in Inorganics. 2017;5(3):56.
doi:10.3390/inorganics5030056 .

Kaluđerović, Goran, Bulatović, Mirna, Krajnović, Tamara, Paschke, Reinhard, B. Zmejkovski, Bojana, Maksimović-Ivanić, Danijela, Mijatović, Sanja, "(18-Crown-6)potassium(I) Trichlorido[28-acetyl-3-(tris-(hydroxylmethyl)amino-ethane)betulinic ester-κN]platinum(II): Synthesis and In Vitro Antitumor Activity" in Inorganics, 5, no. 3 (2017):56,
https://doi.org/10.3390/inorganics5030056 . .

TY  - JOUR
AU  - Ljujić, Mila
AU  - Mijatović, Sanja
AU  - Bulatović, Mirna
AU  - Mojić, Marija
AU  - Maksimović-Ivanić, Danijela
AU  - Radojković, Dragica
AU  - Topić, Aleksandra
PY  - 2017
UR  - http://link.springer.com/10.1007/s12253-016-0104-3
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2729
AB  - Increased circulating alpha-1-antitrypsin (AAT) correlates with cancer stage/aggressiveness, but its role in cancer biology is unclear. We revealed antagonistic effect of AAT to cisplatin-induced cytotoxicity in prostate (PC3) and melanoma (A375) cancer cell lines. Moreover, AAT abrogated cytotoxicity of MEK inhibitor U0126 in PC3 cell line. Weaker antagonistic effect of AAT on cytotoxicity of PI3/Akt and NF-kB inhibitors was also observed. In addition, cisplatin increased AAT gene expression in transfected PC3 cells. However, AAT derived from transfected PC3 cells did not antagonize cisplatin-induced cytotoxicity. In conclusion, these results suggest possible association between high circulating AAT and cisplatin resistance.
T2  - Pathology & Oncology Research
T1  - Alpha-1-Antitrypsin Antagonizes Cisplatin-Induced Cytotoxicity in Prostate Cancer (PC3) and Melanoma Cancer (A375) Cell Lines
IS  - 2
VL  - 23
DO  - 10.1007/s12253-016-0104-3
SP  - 335
EP  - 343
ER  - 

@article{
author = "Ljujić, Mila and Mijatović, Sanja and Bulatović, Mirna and Mojić, Marija and Maksimović-Ivanić, Danijela and Radojković, Dragica and Topić, Aleksandra",
year = "2017",
abstract = "Increased circulating alpha-1-antitrypsin (AAT) correlates with cancer stage/aggressiveness, but its role in cancer biology is unclear. We revealed antagonistic effect of AAT to cisplatin-induced cytotoxicity in prostate (PC3) and melanoma (A375) cancer cell lines. Moreover, AAT abrogated cytotoxicity of MEK inhibitor U0126 in PC3 cell line. Weaker antagonistic effect of AAT on cytotoxicity of PI3/Akt and NF-kB inhibitors was also observed. In addition, cisplatin increased AAT gene expression in transfected PC3 cells. However, AAT derived from transfected PC3 cells did not antagonize cisplatin-induced cytotoxicity. In conclusion, these results suggest possible association between high circulating AAT and cisplatin resistance.",
journal = "Pathology & Oncology Research",
title = "Alpha-1-Antitrypsin Antagonizes Cisplatin-Induced Cytotoxicity in Prostate Cancer (PC3) and Melanoma Cancer (A375) Cell Lines",
number = "2",
volume = "23",
doi = "10.1007/s12253-016-0104-3",
pages = "335-343"
}

Ljujić, M., Mijatović, S., Bulatović, M., Mojić, M., Maksimović-Ivanić, D., Radojković, D.,& Topić, A.. (2017). Alpha-1-Antitrypsin Antagonizes Cisplatin-Induced Cytotoxicity in Prostate Cancer (PC3) and Melanoma Cancer (A375) Cell Lines. in Pathology & Oncology Research, 23(2), 335-343.
https://doi.org/10.1007/s12253-016-0104-3

Ljujić M, Mijatović S, Bulatović M, Mojić M, Maksimović-Ivanić D, Radojković D, Topić A. Alpha-1-Antitrypsin Antagonizes Cisplatin-Induced Cytotoxicity in Prostate Cancer (PC3) and Melanoma Cancer (A375) Cell Lines. in Pathology & Oncology Research. 2017;23(2):335-343.
doi:10.1007/s12253-016-0104-3 .

Ljujić, Mila, Mijatović, Sanja, Bulatović, Mirna, Mojić, Marija, Maksimović-Ivanić, Danijela, Radojković, Dragica, Topić, Aleksandra, "Alpha-1-Antitrypsin Antagonizes Cisplatin-Induced Cytotoxicity in Prostate Cancer (PC3) and Melanoma Cancer (A375) Cell Lines" in Pathology & Oncology Research, 23, no. 2 (2017):335-343,
https://doi.org/10.1007/s12253-016-0104-3 . .

TY  - JOUR
AU  - Ljujic, Mila
AU  - Mijatović, Sanja
AU  - Bulatović, Mirna
AU  - Mojić, Marija
AU  - Maksimović-Ivanić, Danijela
AU  - Radojkovic, Dragica
AU  - Topic, Aleksandra
PY  - 2016
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4166
AB  - Alpha-1-antitrypsin (AAT), an acute phase protein, is the principal circulatory anti-protease. This multifunctional protein is encoded by the SERPINA1 gene. Although AAT was recognised as a potential tumour marker, its role in cancer biology remains unknown. Given that it has been demonstrated that AAT has an anti-apoptotic property against non-malignant cells, we aimed to investigate whether AAT affects apoptosis in a colon cancer cell line (HCT116). The presence of AAT in the HCT116 cell culture antagonized cytotoxicity of blockers of MEK1/2, PI3K/Akt pathways as well as NF-κB. The dominantly recovered cell viability was observed in the co-treatment with MEK1/2 inhibitor U0126. In addition, it was revealed that AAT almost completely abolished U0126-induced apoptosis through maintenance of the autophagy process. Our study revealed for the first time that the observed cyto-protection triggered by AAT was accompanied by sustained autophagy which opposed apoptosis. These results may contribute to understanding of the role of AAT in cancer development and evaluation of efficacy of cancer therapy.
PB  - Moskva: Izdatelstvo Nauka
T2  - Molekuliarnaia biologiia
T1  - Alpha-1 Antitrypsin Affects U0126-Induced Cytotoxicity in Colon Cancer Cell Line (HCT116)
IS  - 1
VL  - 50
DO  - 10.7868/S0026898416010122
SP  - 174
EP  - 178
ER  - 

@article{
author = "Ljujic, Mila and Mijatović, Sanja and Bulatović, Mirna and Mojić, Marija and Maksimović-Ivanić, Danijela and Radojkovic, Dragica and Topic, Aleksandra",
year = "2016",
abstract = "Alpha-1-antitrypsin (AAT), an acute phase protein, is the principal circulatory anti-protease. This multifunctional protein is encoded by the SERPINA1 gene. Although AAT was recognised as a potential tumour marker, its role in cancer biology remains unknown. Given that it has been demonstrated that AAT has an anti-apoptotic property against non-malignant cells, we aimed to investigate whether AAT affects apoptosis in a colon cancer cell line (HCT116). The presence of AAT in the HCT116 cell culture antagonized cytotoxicity of blockers of MEK1/2, PI3K/Akt pathways as well as NF-κB. The dominantly recovered cell viability was observed in the co-treatment with MEK1/2 inhibitor U0126. In addition, it was revealed that AAT almost completely abolished U0126-induced apoptosis through maintenance of the autophagy process. Our study revealed for the first time that the observed cyto-protection triggered by AAT was accompanied by sustained autophagy which opposed apoptosis. These results may contribute to understanding of the role of AAT in cancer development and evaluation of efficacy of cancer therapy.",
publisher = "Moskva: Izdatelstvo Nauka",
journal = "Molekuliarnaia biologiia",
title = "Alpha-1 Antitrypsin Affects U0126-Induced Cytotoxicity in Colon Cancer Cell Line (HCT116)",
number = "1",
volume = "50",
doi = "10.7868/S0026898416010122",
pages = "174-178"
}

Ljujic, M., Mijatović, S., Bulatović, M., Mojić, M., Maksimović-Ivanić, D., Radojkovic, D.,& Topic, A.. (2016). Alpha-1 Antitrypsin Affects U0126-Induced Cytotoxicity in Colon Cancer Cell Line (HCT116). in Molekuliarnaia biologiia
Moskva: Izdatelstvo Nauka., 50(1), 174-178.
https://doi.org/10.7868/S0026898416010122

Ljujic M, Mijatović S, Bulatović M, Mojić M, Maksimović-Ivanić D, Radojkovic D, Topic A. Alpha-1 Antitrypsin Affects U0126-Induced Cytotoxicity in Colon Cancer Cell Line (HCT116). in Molekuliarnaia biologiia. 2016;50(1):174-178.
doi:10.7868/S0026898416010122 .

Ljujic, Mila, Mijatović, Sanja, Bulatović, Mirna, Mojić, Marija, Maksimović-Ivanić, Danijela, Radojkovic, Dragica, Topic, Aleksandra, "Alpha-1 Antitrypsin Affects U0126-Induced Cytotoxicity in Colon Cancer Cell Line (HCT116)" in Molekuliarnaia biologiia, 50, no. 1 (2016):174-178,
https://doi.org/10.7868/S0026898416010122 . .

TY  - JOUR
AU  - Ludwig, Gerd
AU  - Mojić, Marija
AU  - Bulatović, Mirna
AU  - Mijatović, Sanja
AU  - Maksimović-Ivanić, Danijela
AU  - Steinborn, Dirk
AU  - Kaluđerović, Goran N
PY  - 2016
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3827
AB  - In vitro studies with the ruthenium(II) and analogous iridium(III) complexes [Ru(η6- p-cymene)Cl2{Ph2PCH2CH2CH2S(O)xPh-κP}], [Ru(η6-p-cymene)Cl{Ph2PCH2CH2CH2S(O)xPh- κP,κS}][PF6] (1-4), [Ir(η5-C5Me5)Cl2{Ph2PCH2CH2CH2S(O)xPh-κP}] and [Ir(η5-C5Me5)Cl{Ph2 PCH2CH2CH2S(O)xPh-κP,κS}][PF6] (5-8; x = 0, 1) revealed the high selectivity toward the 8505C, A253, MCF-7, SW480 and 518A2 cancer cell lines. Thus, the cationic ruthenium complex 4 proved to be the most selective one. In case of the neutral and cationic ruthenium complexes 1-4 the caspase-dependent apoptotic cell death was proven as the main cause of the drug's tumoricidal action on 8505C cell line.
PB  - Sharjah: Bentham Science Publishers
T2  - Anti-Cancer Agents in Medicinal Chemistry
T1  - Biological Potential of Halfsandwich Ruthenium(II) and Iridium (III) Complexes
IS  - 11
VL  - 16
DO  - 10.2174/1871520615666151029100749
SP  - 1455
EP  - 1460
ER  - 

@article{
author = "Ludwig, Gerd and Mojić, Marija and Bulatović, Mirna and Mijatović, Sanja and Maksimović-Ivanić, Danijela and Steinborn, Dirk and Kaluđerović, Goran N",
year = "2016",
abstract = "In vitro studies with the ruthenium(II) and analogous iridium(III) complexes [Ru(η6- p-cymene)Cl2{Ph2PCH2CH2CH2S(O)xPh-κP}], [Ru(η6-p-cymene)Cl{Ph2PCH2CH2CH2S(O)xPh- κP,κS}][PF6] (1-4), [Ir(η5-C5Me5)Cl2{Ph2PCH2CH2CH2S(O)xPh-κP}] and [Ir(η5-C5Me5)Cl{Ph2 PCH2CH2CH2S(O)xPh-κP,κS}][PF6] (5-8; x = 0, 1) revealed the high selectivity toward the 8505C, A253, MCF-7, SW480 and 518A2 cancer cell lines. Thus, the cationic ruthenium complex 4 proved to be the most selective one. In case of the neutral and cationic ruthenium complexes 1-4 the caspase-dependent apoptotic cell death was proven as the main cause of the drug's tumoricidal action on 8505C cell line.",
publisher = "Sharjah: Bentham Science Publishers",
journal = "Anti-Cancer Agents in Medicinal Chemistry",
title = "Biological Potential of Halfsandwich Ruthenium(II) and Iridium (III) Complexes",
number = "11",
volume = "16",
doi = "10.2174/1871520615666151029100749",
pages = "1455-1460"
}

Ludwig, G., Mojić, M., Bulatović, M., Mijatović, S., Maksimović-Ivanić, D., Steinborn, D.,& Kaluđerović, G. N.. (2016). Biological Potential of Halfsandwich Ruthenium(II) and Iridium (III) Complexes. in Anti-Cancer Agents in Medicinal Chemistry
Sharjah: Bentham Science Publishers., 16(11), 1455-1460.
https://doi.org/10.2174/1871520615666151029100749

Ludwig G, Mojić M, Bulatović M, Mijatović S, Maksimović-Ivanić D, Steinborn D, Kaluđerović GN. Biological Potential of Halfsandwich Ruthenium(II) and Iridium (III) Complexes. in Anti-Cancer Agents in Medicinal Chemistry. 2016;16(11):1455-1460.
doi:10.2174/1871520615666151029100749 .

Ludwig, Gerd, Mojić, Marija, Bulatović, Mirna, Mijatović, Sanja, Maksimović-Ivanić, Danijela, Steinborn, Dirk, Kaluđerović, Goran N, "Biological Potential of Halfsandwich Ruthenium(II) and Iridium (III) Complexes" in Anti-Cancer Agents in Medicinal Chemistry, 16, no. 11 (2016):1455-1460,
https://doi.org/10.2174/1871520615666151029100749 . .

TY  - JOUR
AU  - Maksimović-Ivanić, Danijela
AU  - Mojić, Marija
AU  - Bulatović, Mirna Z.
AU  - Radojkovic, Milica
AU  - Kuzmanovic, Milos
AU  - Ristic, Slobodan
AU  - Stošić-Grujičić, Stanislava
AU  - Miljković, Đorđe
AU  - Cavalli, Eugenio
AU  - Libra, Massimo
AU  - Fagone, Paolo
AU  - McCubrey, James
AU  - Nicoletti, Ferdinando
AU  - Mijatović, Sanja
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2353
AB  - Covalent attachment of NO to the first approved HIV protease inhibitor
   Saquinavir (Saq-NO) expands the therapeutic potential of the original
   drug. Apart from retained antiviral activity, the modified drug exerts
   strong antitumor effects and lower toxicity. In the present study, we
   have evaluated the sensitivity of different hematological malignancies
   to Saq-NO. Saq-NO efficiently diminished the viability of Jurkat, Raji,
   HL-60 and K562 cells. While Jurkat and Raji cells (established from
   pediatric patients) displayed abrogated proliferative potential, HL-60
   and K652 cells (originated from adults) exposed to Saq-NO treatment
   underwent caspase dependent apoptosis. In addition, similar sensitivity
   to Saq-NO was observed in mononuclear blood cells obtained from
   pediatric patients with acute lymphoblastic leukemia (ALL) and adult
   patients with acute myeloid leukemia (AML). Western blot analysis
   indicated p70S6 kinase as a possible intracellular target of Saq-NO
   action. Moreover, the addition of a NO moiety to Lopinavir resulted in
   improved antitumor potential as compared to the parental compound,
   suggesting that NO-derived HIV protease inhibitors are a potential new
   source of anticancer drugs with unique mode of action. (C) 2015 Elsevier
   Ltd. All rights reserved.
T2  - Leukemia Research
T1  - The NO-modified HIV protease inhibitor as a valuable drug for
 hematological malignancies: Role of p70S6K
IS  - 10
VL  - 39
DO  - 10.1016/j.leukres.2015.06.013
SP  - 1088
EP  - 1095
ER  - 

@article{
author = "Maksimović-Ivanić, Danijela and Mojić, Marija and Bulatović, Mirna Z. and Radojkovic, Milica and Kuzmanovic, Milos and Ristic, Slobodan and Stošić-Grujičić, Stanislava and Miljković, Đorđe and Cavalli, Eugenio and Libra, Massimo and Fagone, Paolo and McCubrey, James and Nicoletti, Ferdinando and Mijatović, Sanja",
year = "2015",
abstract = "Covalent attachment of NO to the first approved HIV protease inhibitor
   Saquinavir (Saq-NO) expands the therapeutic potential of the original
   drug. Apart from retained antiviral activity, the modified drug exerts
   strong antitumor effects and lower toxicity. In the present study, we
   have evaluated the sensitivity of different hematological malignancies
   to Saq-NO. Saq-NO efficiently diminished the viability of Jurkat, Raji,
   HL-60 and K562 cells. While Jurkat and Raji cells (established from
   pediatric patients) displayed abrogated proliferative potential, HL-60
   and K652 cells (originated from adults) exposed to Saq-NO treatment
   underwent caspase dependent apoptosis. In addition, similar sensitivity
   to Saq-NO was observed in mononuclear blood cells obtained from
   pediatric patients with acute lymphoblastic leukemia (ALL) and adult
   patients with acute myeloid leukemia (AML). Western blot analysis
   indicated p70S6 kinase as a possible intracellular target of Saq-NO
   action. Moreover, the addition of a NO moiety to Lopinavir resulted in
   improved antitumor potential as compared to the parental compound,
   suggesting that NO-derived HIV protease inhibitors are a potential new
   source of anticancer drugs with unique mode of action. (C) 2015 Elsevier
   Ltd. All rights reserved.",
journal = "Leukemia Research",
title = "The NO-modified HIV protease inhibitor as a valuable drug for
 hematological malignancies: Role of p70S6K",
number = "10",
volume = "39",
doi = "10.1016/j.leukres.2015.06.013",
pages = "1088-1095"
}

Maksimović-Ivanić, D., Mojić, M., Bulatović, M. Z., Radojkovic, M., Kuzmanovic, M., Ristic, S., Stošić-Grujičić, S., Miljković, Đ., Cavalli, E., Libra, M., Fagone, P., McCubrey, J., Nicoletti, F.,& Mijatović, S.. (2015). The NO-modified HIV protease inhibitor as a valuable drug for
 hematological malignancies: Role of p70S6K. in Leukemia Research, 39(10), 1088-1095.
https://doi.org/10.1016/j.leukres.2015.06.013

Maksimović-Ivanić D, Mojić M, Bulatović MZ, Radojkovic M, Kuzmanovic M, Ristic S, Stošić-Grujičić S, Miljković Đ, Cavalli E, Libra M, Fagone P, McCubrey J, Nicoletti F, Mijatović S. The NO-modified HIV protease inhibitor as a valuable drug for
 hematological malignancies: Role of p70S6K. in Leukemia Research. 2015;39(10):1088-1095.
doi:10.1016/j.leukres.2015.06.013 .

Maksimović-Ivanić, Danijela, Mojić, Marija, Bulatović, Mirna Z., Radojkovic, Milica, Kuzmanovic, Milos, Ristic, Slobodan, Stošić-Grujičić, Stanislava, Miljković, Đorđe, Cavalli, Eugenio, Libra, Massimo, Fagone, Paolo, McCubrey, James, Nicoletti, Ferdinando, Mijatović, Sanja, "The NO-modified HIV protease inhibitor as a valuable drug for
 hematological malignancies: Role of p70S6K" in Leukemia Research, 39, no. 10 (2015):1088-1095,
https://doi.org/10.1016/j.leukres.2015.06.013 . .

TY  - JOUR
AU  - Bulatović, Mirna Z.
AU  - Kaluderovic, Milena R.
AU  - Mojić, Marija
AU  - Zmejkovski, Bojana B.
AU  - Hey-Hawkins, Evamarie
AU  - Vidaković, Melita
AU  - Grdović, Nevena
AU  - Kaluđerović, Goran N.
AU  - Mijatović, Sanja
AU  - Maksimović-Ivanić, Danijela
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1916
AB  - (O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplati
   num(IV), {[}PtCl4(iBu(2)eddp)]. shows an improved pharmacological
   profile in comparison to cisplatin. This is manifested through
   accelerated dying process led by necrotic cell death, reflected through
   mitochondrial collapse, strong ATP depletion and reactive oxygen species
   production. Loss of mitochondrial potential was further followed with
   intensive apoptosis that finalized with DNA fragmentation.
   Different dynamic of tumoricidal action could be partly ascribed to less
   affected repair mechanisms in comparison to cisplatin. Importantly,
   {[}PtCl4(iBu(2)eddp)] did not induce necrosis in primary fibroblasts
   suggesting different intracellular response of normal vs. tumor cells.
   This selectivity toward malignant phenotype is further confirmed by
   retained tumoricidal potential in hypoxic conditions, while cisplatin
   became completely inefficient. (C) 2015 Published by Elsevier B.V.
T2  - European Journal of Pharmacology
T1  - Improved in vitro antitumor potential of
 (O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplati
 num(IV) complex under normoxic and hypoxic conditions
VL  - 760
DO  - 10.1016/j.ejphar.2015.04.012
SP  - 136
EP  - 144
ER  - 

@article{
author = "Bulatović, Mirna Z. and Kaluderovic, Milena R. and Mojić, Marija and Zmejkovski, Bojana B. and Hey-Hawkins, Evamarie and Vidaković, Melita and Grdović, Nevena and Kaluđerović, Goran N. and Mijatović, Sanja and Maksimović-Ivanić, Danijela",
year = "2015",
abstract = "(O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplati
   num(IV), {[}PtCl4(iBu(2)eddp)]. shows an improved pharmacological
   profile in comparison to cisplatin. This is manifested through
   accelerated dying process led by necrotic cell death, reflected through
   mitochondrial collapse, strong ATP depletion and reactive oxygen species
   production. Loss of mitochondrial potential was further followed with
   intensive apoptosis that finalized with DNA fragmentation.
   Different dynamic of tumoricidal action could be partly ascribed to less
   affected repair mechanisms in comparison to cisplatin. Importantly,
   {[}PtCl4(iBu(2)eddp)] did not induce necrosis in primary fibroblasts
   suggesting different intracellular response of normal vs. tumor cells.
   This selectivity toward malignant phenotype is further confirmed by
   retained tumoricidal potential in hypoxic conditions, while cisplatin
   became completely inefficient. (C) 2015 Published by Elsevier B.V.",
journal = "European Journal of Pharmacology",
title = "Improved in vitro antitumor potential of
 (O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplati
 num(IV) complex under normoxic and hypoxic conditions",
volume = "760",
doi = "10.1016/j.ejphar.2015.04.012",
pages = "136-144"
}

Bulatović, M. Z., Kaluderovic, M. R., Mojić, M., Zmejkovski, B. B., Hey-Hawkins, E., Vidaković, M., Grdović, N., Kaluđerović, G. N., Mijatović, S.,& Maksimović-Ivanić, D.. (2015). Improved in vitro antitumor potential of
 (O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplati
 num(IV) complex under normoxic and hypoxic conditions. in European Journal of Pharmacology, 760, 136-144.
https://doi.org/10.1016/j.ejphar.2015.04.012

Bulatović MZ, Kaluderovic MR, Mojić M, Zmejkovski BB, Hey-Hawkins E, Vidaković M, Grdović N, Kaluđerović GN, Mijatović S, Maksimović-Ivanić D. Improved in vitro antitumor potential of
 (O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplati
 num(IV) complex under normoxic and hypoxic conditions. in European Journal of Pharmacology. 2015;760:136-144.
doi:10.1016/j.ejphar.2015.04.012 .

Bulatović, Mirna Z., Kaluderovic, Milena R., Mojić, Marija, Zmejkovski, Bojana B., Hey-Hawkins, Evamarie, Vidaković, Melita, Grdović, Nevena, Kaluđerović, Goran N., Mijatović, Sanja, Maksimović-Ivanić, Danijela, "Improved in vitro antitumor potential of
 (O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplati
 num(IV) complex under normoxic and hypoxic conditions" in European Journal of Pharmacology, 760 (2015):136-144,
https://doi.org/10.1016/j.ejphar.2015.04.012 . .

TY  - THES
AU  - Bulatović, Mirna
PY  - 2015
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=2775
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:10940/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=1025022642
UR  - http://nardus.mpn.gov.rs/123456789/5167
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2380
AB  - Uprkos razvoju imunoterapije i ciljanih terapija, globalna incidenca melanoma nastavlja da raste. Konvencionalna hemoterapija, naţalost, pokazuje ograniĉenu efikasnost u leĉenju metastatskog melanoma. Primenu najĉešće korišćenog hemoterapeutskog leka cisplatine, ograniĉava uroĊena rezistencija ovog tipa tumora, što sve naglašava potrebu za razvojem efikasnije hemoterapije melanoma. Progres u medicinskoj organometalnoj hemiji omogućio je racionalni dizajn novih, nekonvencionalnih platinskih kompleksa, kao i neplatinskih antitumorskih jedinjenja, ukljuĉujući organokalajna jedinjenja, ĉija aktivnost ne poĉiva na direktnoj interakciji sa DNK. MeĊutim, nedovoljna rastvorljivost i toksiĉnost organokalajnih jedinjenja ograniĉava kompleksnija istraţivanja i ulazak u kliniĉka ispitivanja. U tom kontekstu, primena nanotehnologije u svrhu povećanja rastvorljivosti lekova i njihove selektivnosti prema maligno transformisanim klonovima u hemoterapiji kancera ima vodeću ulogu. Inkapsulacija hidrofobnih antitumorskih lekova u mezoporozne nanomaterijale silike, predstavlja najperspektivniju strategiju u ovoj oblasti. Zbog visokog potencijala za adsorpciju, nosaĉ SBA-15 je najinteresantniji mezoporozni silikat za ciljanu isporuku lekova. U skladu sa tim, u ovoj studiji je po prvi put ispitivan antitumorski potencijal organokalajnog(IV) jedinjenja [Ph3Sn(CH2)6OH] skladištenog u mezoporozni materijal SBA-15 (SBA-15pSn) in vitro i in vivo u modelu mišjeg melanoma. Imajući u vidu izuzetnu heterogenost melanoma, ispitivan je i njihov uticaj na visoko invazivnu liniju humanog melanoma, A375. Analizirani su ćelijski i molekulski mehanizmi pokrenuti u odgovoru na tretman eksperimentalnim agensima u ćelijama melanoma, kao i mehanizam preuzimanja ĉestica SBA-15pSn u humane ćelije melanoma u sistemu in vitro.[Ph3Sn(CH2)6OH] u slobodnoj formi ali, mnogo potentnije, uskladišten u SBA-15 smanjio je vijabilitet ćelijskih linija melanoma poreklom od miša B16, i ĉoveka A375. Isti trend je zapaţen u singenom modelu mišjeg melanoma in vivo. Pokazalo se da A375 ćelije melanoma preuzimaju SBA-15pSn pasivnim putem i makropinocitozom.
AB  - Despite rapid development in immunotherapy and targeted therapies, the global incidence of melanoma continues to increase. Besides, conventional chemotherapy demonstrates only limited efficacy in the treatment of advanced melanoma. Clinical application of widely used chemotherapeutic drug cisplatin, is hampered by the intrinsic resistance of this type of tumor, indicating the urgent need for the development of more effective chemotherapies for melanoma. The rapid progress in medicinal organometallic chemistry in the past few years allows rational design of novel platinum compounds, as well as nonplatinum metal-based antitumor agents, including organotin compounds, whose activity is not based on unrepairable interaction with DNA. Poor solubility and toxicity of organotin compounds, however, restrains more complex studies and further development in the preclinical and subsequently clinical setting. Nanotechnology now becomes an important part of pharmaceutical research and development, for improving the solubility and selective toxicity of cancer therapeutics. Encapsulating hydrophobic antitumor agents in ordered mesoporous silica nanomaterials is an emerging strategy to enhance drug dissolution. Due to its high drug loading capacity, SBA-15 is the most interesting mesoporous silicate for targeted drug delivery. Antitumor potential of organotin(IV) compound [Ph3Sn(CH2)6OH] grafted on nanostructured material SBA-15 (SBA-15pSn) in vitro and in vivo in the mouse model of melanoma, was tested for the first time in this study. Considering the enormous heterogeneity of this type of tumor, it was of interest to test these experimental therapeutics in a highly invasive human A375 melanoma cell line. Given the fact that SBA-15pSn nanoparticles are relatively large, the mechanism of cellular uptake was defined. At the molecular level, main intracellular events triggered by the treatment, as well as the expression of key signaling pathways mediating tumor cell response, were analyzed...
PB  - Belgrade: University of Belgrade, Faculty of Biology
T2  - University of Belgrade, Faculty of Biology
T1  - Ispitivanje antitumorskog delovanja 6-[trifenilstanil]-1-heksanola vezanog za mezoporozni nanomaterijal SBA-15 u modelu mišjeg melanoma in vitro i in vivo
T1  - Evaluation of antitumor activity of 6-(triphenylstannyl)hexan-1-ol loaded in SBA-15 mesoporous nanostructured material in the mouse model of melanoma in vitro and in vivo
SP  - 1
EP  - 122
UR  - https://hdl.handle.net/21.15107/rcub_nardus_5167
ER  - 

@phdthesis{
author = "Bulatović, Mirna",
year = "2015",
abstract = "Uprkos razvoju imunoterapije i ciljanih terapija, globalna incidenca melanoma nastavlja da raste. Konvencionalna hemoterapija, naţalost, pokazuje ograniĉenu efikasnost u leĉenju metastatskog melanoma. Primenu najĉešće korišćenog hemoterapeutskog leka cisplatine, ograniĉava uroĊena rezistencija ovog tipa tumora, što sve naglašava potrebu za razvojem efikasnije hemoterapije melanoma. Progres u medicinskoj organometalnoj hemiji omogućio je racionalni dizajn novih, nekonvencionalnih platinskih kompleksa, kao i neplatinskih antitumorskih jedinjenja, ukljuĉujući organokalajna jedinjenja, ĉija aktivnost ne poĉiva na direktnoj interakciji sa DNK. MeĊutim, nedovoljna rastvorljivost i toksiĉnost organokalajnih jedinjenja ograniĉava kompleksnija istraţivanja i ulazak u kliniĉka ispitivanja. U tom kontekstu, primena nanotehnologije u svrhu povećanja rastvorljivosti lekova i njihove selektivnosti prema maligno transformisanim klonovima u hemoterapiji kancera ima vodeću ulogu. Inkapsulacija hidrofobnih antitumorskih lekova u mezoporozne nanomaterijale silike, predstavlja najperspektivniju strategiju u ovoj oblasti. Zbog visokog potencijala za adsorpciju, nosaĉ SBA-15 je najinteresantniji mezoporozni silikat za ciljanu isporuku lekova. U skladu sa tim, u ovoj studiji je po prvi put ispitivan antitumorski potencijal organokalajnog(IV) jedinjenja [Ph3Sn(CH2)6OH] skladištenog u mezoporozni materijal SBA-15 (SBA-15pSn) in vitro i in vivo u modelu mišjeg melanoma. Imajući u vidu izuzetnu heterogenost melanoma, ispitivan je i njihov uticaj na visoko invazivnu liniju humanog melanoma, A375. Analizirani su ćelijski i molekulski mehanizmi pokrenuti u odgovoru na tretman eksperimentalnim agensima u ćelijama melanoma, kao i mehanizam preuzimanja ĉestica SBA-15pSn u humane ćelije melanoma u sistemu in vitro.[Ph3Sn(CH2)6OH] u slobodnoj formi ali, mnogo potentnije, uskladišten u SBA-15 smanjio je vijabilitet ćelijskih linija melanoma poreklom od miša B16, i ĉoveka A375. Isti trend je zapaţen u singenom modelu mišjeg melanoma in vivo. Pokazalo se da A375 ćelije melanoma preuzimaju SBA-15pSn pasivnim putem i makropinocitozom., Despite rapid development in immunotherapy and targeted therapies, the global incidence of melanoma continues to increase. Besides, conventional chemotherapy demonstrates only limited efficacy in the treatment of advanced melanoma. Clinical application of widely used chemotherapeutic drug cisplatin, is hampered by the intrinsic resistance of this type of tumor, indicating the urgent need for the development of more effective chemotherapies for melanoma. The rapid progress in medicinal organometallic chemistry in the past few years allows rational design of novel platinum compounds, as well as nonplatinum metal-based antitumor agents, including organotin compounds, whose activity is not based on unrepairable interaction with DNA. Poor solubility and toxicity of organotin compounds, however, restrains more complex studies and further development in the preclinical and subsequently clinical setting. Nanotechnology now becomes an important part of pharmaceutical research and development, for improving the solubility and selective toxicity of cancer therapeutics. Encapsulating hydrophobic antitumor agents in ordered mesoporous silica nanomaterials is an emerging strategy to enhance drug dissolution. Due to its high drug loading capacity, SBA-15 is the most interesting mesoporous silicate for targeted drug delivery. Antitumor potential of organotin(IV) compound [Ph3Sn(CH2)6OH] grafted on nanostructured material SBA-15 (SBA-15pSn) in vitro and in vivo in the mouse model of melanoma, was tested for the first time in this study. Considering the enormous heterogeneity of this type of tumor, it was of interest to test these experimental therapeutics in a highly invasive human A375 melanoma cell line. Given the fact that SBA-15pSn nanoparticles are relatively large, the mechanism of cellular uptake was defined. At the molecular level, main intracellular events triggered by the treatment, as well as the expression of key signaling pathways mediating tumor cell response, were analyzed...",
publisher = "Belgrade: University of Belgrade, Faculty of Biology",
journal = "University of Belgrade, Faculty of Biology",
title = "Ispitivanje antitumorskog delovanja 6-[trifenilstanil]-1-heksanola vezanog za mezoporozni nanomaterijal SBA-15 u modelu mišjeg melanoma in vitro i in vivo, Evaluation of antitumor activity of 6-(triphenylstannyl)hexan-1-ol loaded in SBA-15 mesoporous nanostructured material in the mouse model of melanoma in vitro and in vivo",
pages = "1-122",
url = "https://hdl.handle.net/21.15107/rcub_nardus_5167"
}

Bulatović, M.. (2015). Ispitivanje antitumorskog delovanja 6-[trifenilstanil]-1-heksanola vezanog za mezoporozni nanomaterijal SBA-15 u modelu mišjeg melanoma in vitro i in vivo. in University of Belgrade, Faculty of Biology
Belgrade: University of Belgrade, Faculty of Biology., 1-122.
https://hdl.handle.net/21.15107/rcub_nardus_5167

Bulatović M. Ispitivanje antitumorskog delovanja 6-[trifenilstanil]-1-heksanola vezanog za mezoporozni nanomaterijal SBA-15 u modelu mišjeg melanoma in vitro i in vivo. in University of Belgrade, Faculty of Biology. 2015;:1-122.
https://hdl.handle.net/21.15107/rcub_nardus_5167 .

Bulatović, Mirna, "Ispitivanje antitumorskog delovanja 6-[trifenilstanil]-1-heksanola vezanog za mezoporozni nanomaterijal SBA-15 u modelu mišjeg melanoma in vitro i in vivo" in University of Belgrade, Faculty of Biology (2015):1-122,
https://hdl.handle.net/21.15107/rcub_nardus_5167 .

TY  - JOUR
AU  - Mijatović, Sanja
AU  - Bulatović, Mirna Z.
AU  - Mojić, Marija
AU  - Stošić-Grujičić, Stanislava
AU  - Miljković, Đorđe
AU  - Maksimović-Ivanić, Danijela
AU  - Gomez-Ruiz, Santiago
AU  - Pinkas, Jiri
AU  - Horacek, Michal
AU  - Kaluđerović, Goran N.
PY  - 2014
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2247
AB  - The previously known complexes {[}Ti\{(Me2CMe2C)(eta(5)-C5H4)(2)\}Cl-2]
   (1), {[}Ti\{Me2C(eta(5)-C5H4)(2)\}Cl-2] (2), {[}Ti
   \{Me2Si(eta(5)-C5H4)(2)\}Cl-2] (4), {[}Ti\{MePhSi(eta(5)-C5H4)(2)\}Cl-2]
   (5) and {[}Ti\{MePhSi(eta(5)-C5Me4)(2)\}Cl-2] (6) have been prepared
   following reported procedures. The novel complex
   {[}Ti\{MePhC(eta(5)-C5H4)(2)\}Cl-2] (3) has been prepared and
   characterized. The cytotoxic activity of 1-6 has been tested after 72 h
   on melanoma A375 and B16, prostate cancer DU145 and LNCaP and colon
   cancer HCT116, SW620 and CT26CL25 cell lines observing a high cytotoxic
   activity of complexes 1 and 6 compared to the reference compound
   ({[}Ti(eta(5)-C5H5)(2)\}Cl-2]). 1 and 6 have also been tested against
   primary normal mouse keratinocytes and lung fibroblasts. While viability
   of both type of primary cells was significantly less affected by 1 in
   comparison to the reference compound {[}Ti(eta(5)-C5H5)(2)Cl-2],
   compound 6 was completely nontoxic for nonmalignant cells, indicating a
   potential selectivity of this compound towards cancer cell lines. In
   addition CFSE staining, cell cycle analysis, AnnexinV-FITC/PI staining,
   detection of caspase activity and mitochondrial potential showed that 1
   and 6 were acting through inhibition of proliferation and subsequent
   induction of mitochondrial dependent apoptosis in colon cancer cell
   lines, HCT116 and SW620, which express low sensitivity to cisplatin.
   Compound 6 was found to be the leading drug in this group since it shows
   the fastest and most selective anticancer profile. (C) 2013 Elsevier
   B.V. All rights reserved.
T2  - Journal of Organometallic Chemistry
T1  - Study of the anticancer properties of methyl- and phenyl-substituted
 carbon- and silicon-bridged ansa-titanocene complexes
VL  - 751
DO  - 10.1016/j.jorganchem.2013.07.059
SP  - 361
EP  - 367
ER  - 

@article{
author = "Mijatović, Sanja and Bulatović, Mirna Z. and Mojić, Marija and Stošić-Grujičić, Stanislava and Miljković, Đorđe and Maksimović-Ivanić, Danijela and Gomez-Ruiz, Santiago and Pinkas, Jiri and Horacek, Michal and Kaluđerović, Goran N.",
year = "2014",
abstract = "The previously known complexes {[}Ti\{(Me2CMe2C)(eta(5)-C5H4)(2)\}Cl-2]
   (1), {[}Ti\{Me2C(eta(5)-C5H4)(2)\}Cl-2] (2), {[}Ti
   \{Me2Si(eta(5)-C5H4)(2)\}Cl-2] (4), {[}Ti\{MePhSi(eta(5)-C5H4)(2)\}Cl-2]
   (5) and {[}Ti\{MePhSi(eta(5)-C5Me4)(2)\}Cl-2] (6) have been prepared
   following reported procedures. The novel complex
   {[}Ti\{MePhC(eta(5)-C5H4)(2)\}Cl-2] (3) has been prepared and
   characterized. The cytotoxic activity of 1-6 has been tested after 72 h
   on melanoma A375 and B16, prostate cancer DU145 and LNCaP and colon
   cancer HCT116, SW620 and CT26CL25 cell lines observing a high cytotoxic
   activity of complexes 1 and 6 compared to the reference compound
   ({[}Ti(eta(5)-C5H5)(2)\}Cl-2]). 1 and 6 have also been tested against
   primary normal mouse keratinocytes and lung fibroblasts. While viability
   of both type of primary cells was significantly less affected by 1 in
   comparison to the reference compound {[}Ti(eta(5)-C5H5)(2)Cl-2],
   compound 6 was completely nontoxic for nonmalignant cells, indicating a
   potential selectivity of this compound towards cancer cell lines. In
   addition CFSE staining, cell cycle analysis, AnnexinV-FITC/PI staining,
   detection of caspase activity and mitochondrial potential showed that 1
   and 6 were acting through inhibition of proliferation and subsequent
   induction of mitochondrial dependent apoptosis in colon cancer cell
   lines, HCT116 and SW620, which express low sensitivity to cisplatin.
   Compound 6 was found to be the leading drug in this group since it shows
   the fastest and most selective anticancer profile. (C) 2013 Elsevier
   B.V. All rights reserved.",
journal = "Journal of Organometallic Chemistry",
title = "Study of the anticancer properties of methyl- and phenyl-substituted
 carbon- and silicon-bridged ansa-titanocene complexes",
volume = "751",
doi = "10.1016/j.jorganchem.2013.07.059",
pages = "361-367"
}

Mijatović, S., Bulatović, M. Z., Mojić, M., Stošić-Grujičić, S., Miljković, Đ., Maksimović-Ivanić, D., Gomez-Ruiz, S., Pinkas, J., Horacek, M.,& Kaluđerović, G. N.. (2014). Study of the anticancer properties of methyl- and phenyl-substituted
 carbon- and silicon-bridged ansa-titanocene complexes. in Journal of Organometallic Chemistry, 751, 361-367.
https://doi.org/10.1016/j.jorganchem.2013.07.059

Mijatović S, Bulatović MZ, Mojić M, Stošić-Grujičić S, Miljković Đ, Maksimović-Ivanić D, Gomez-Ruiz S, Pinkas J, Horacek M, Kaluđerović GN. Study of the anticancer properties of methyl- and phenyl-substituted
 carbon- and silicon-bridged ansa-titanocene complexes. in Journal of Organometallic Chemistry. 2014;751:361-367.
doi:10.1016/j.jorganchem.2013.07.059 .

Mijatović, Sanja, Bulatović, Mirna Z., Mojić, Marija, Stošić-Grujičić, Stanislava, Miljković, Đorđe, Maksimović-Ivanić, Danijela, Gomez-Ruiz, Santiago, Pinkas, Jiri, Horacek, Michal, Kaluđerović, Goran N., "Study of the anticancer properties of methyl- and phenyl-substituted
 carbon- and silicon-bridged ansa-titanocene complexes" in Journal of Organometallic Chemistry, 751 (2014):361-367,
https://doi.org/10.1016/j.jorganchem.2013.07.059 . .

TY  - JOUR
AU  - Mojić, Marija
AU  - Savic, Aleksandar
AU  - Arion, Vladimir B.
AU  - Bulatović, Mirna Z.
AU  - Poljarevic, Jelena M.
AU  - Miljković, Đorđe
AU  - Sabo, Tibor J.
AU  - Mijatović, Sanja
AU  - Maksimović-Ivanić, Danijela
AU  - Grguric-Sipka, Sanja
PY  - 2014
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2310
AB  - Two p-cymene ruthenium chlorido complexes containing isobutyl (C1) and
   isoamyl (C2) esters of (S,S)ethylenediamine-N,N'-di-2-(3-cyclohexyl)
   propanoic acid as ligands were prepared from p-cymene ruthenium
   dichloride dimer and corresponding ester. All compounds have been
   characterized by elemental analysis, IR, ESI-MS, H-1 and C-13 NMR
   spectroscopy. Single crystal X-ray structure diffraction analysis of C1
   shows the usual piano-stool geometry of complexes, with coordination of
   ester ligand via nitrogen donor atoms. Ligands exhibit moderate
   anticancer activity (IC50 > 50 mu M), while the complexes were
   significantly more cytotoxic towards various cancer cell lines,
   including B16, A375, HCT116, A549 and MCF7 cells (IC50 min.-max. 2.9-8.0
   mu M). We stress that cisplatin resistant HCT116 cell line was highly
   sensitive to the treatment with C1 and C2 (IC50 values: 4.4 and 5.5 mu M
   versus IC50 > 120 mu M for cisplatin). In parallel, primary
   fibroblasts-MRC-5 were remarkably less affected by these compounds. (C)
   2013 Elsevier B. V. All rights reserved.
T2  - Journal of Organometallic Chemistry
T1  - Synthesis, X-ray structure and strong in vitro cytotoxicity of novel
 organoruthenium complexes
VL  - 749
DO  - 10.1016/j.jorganchem.2013.08.041
SP  - 142
EP  - 149
ER  - 

@article{
author = "Mojić, Marija and Savic, Aleksandar and Arion, Vladimir B. and Bulatović, Mirna Z. and Poljarevic, Jelena M. and Miljković, Đorđe and Sabo, Tibor J. and Mijatović, Sanja and Maksimović-Ivanić, Danijela and Grguric-Sipka, Sanja",
year = "2014",
abstract = "Two p-cymene ruthenium chlorido complexes containing isobutyl (C1) and
   isoamyl (C2) esters of (S,S)ethylenediamine-N,N'-di-2-(3-cyclohexyl)
   propanoic acid as ligands were prepared from p-cymene ruthenium
   dichloride dimer and corresponding ester. All compounds have been
   characterized by elemental analysis, IR, ESI-MS, H-1 and C-13 NMR
   spectroscopy. Single crystal X-ray structure diffraction analysis of C1
   shows the usual piano-stool geometry of complexes, with coordination of
   ester ligand via nitrogen donor atoms. Ligands exhibit moderate
   anticancer activity (IC50 > 50 mu M), while the complexes were
   significantly more cytotoxic towards various cancer cell lines,
   including B16, A375, HCT116, A549 and MCF7 cells (IC50 min.-max. 2.9-8.0
   mu M). We stress that cisplatin resistant HCT116 cell line was highly
   sensitive to the treatment with C1 and C2 (IC50 values: 4.4 and 5.5 mu M
   versus IC50 > 120 mu M for cisplatin). In parallel, primary
   fibroblasts-MRC-5 were remarkably less affected by these compounds. (C)
   2013 Elsevier B. V. All rights reserved.",
journal = "Journal of Organometallic Chemistry",
title = "Synthesis, X-ray structure and strong in vitro cytotoxicity of novel
 organoruthenium complexes",
volume = "749",
doi = "10.1016/j.jorganchem.2013.08.041",
pages = "142-149"
}

Mojić, M., Savic, A., Arion, V. B., Bulatović, M. Z., Poljarevic, J. M., Miljković, Đ., Sabo, T. J., Mijatović, S., Maksimović-Ivanić, D.,& Grguric-Sipka, S.. (2014). Synthesis, X-ray structure and strong in vitro cytotoxicity of novel
 organoruthenium complexes. in Journal of Organometallic Chemistry, 749, 142-149.
https://doi.org/10.1016/j.jorganchem.2013.08.041

Mojić M, Savic A, Arion VB, Bulatović MZ, Poljarevic JM, Miljković Đ, Sabo TJ, Mijatović S, Maksimović-Ivanić D, Grguric-Sipka S. Synthesis, X-ray structure and strong in vitro cytotoxicity of novel
 organoruthenium complexes. in Journal of Organometallic Chemistry. 2014;749:142-149.
doi:10.1016/j.jorganchem.2013.08.041 .

Mojić, Marija, Savic, Aleksandar, Arion, Vladimir B., Bulatović, Mirna Z., Poljarevic, Jelena M., Miljković, Đorđe, Sabo, Tibor J., Mijatović, Sanja, Maksimović-Ivanić, Danijela, Grguric-Sipka, Sanja, "Synthesis, X-ray structure and strong in vitro cytotoxicity of novel
 organoruthenium complexes" in Journal of Organometallic Chemistry, 749 (2014):142-149,
https://doi.org/10.1016/j.jorganchem.2013.08.041 . .

TY  - JOUR
AU  - Bulatović, Mirna Z.
AU  - Maksimović-Ivanić, Danijela
AU  - Bensing, Christian
AU  - Gomez-Ruiz, Santiago
AU  - Steinborn, Dirk
AU  - Schmidt, Harry
AU  - Mojić, Marija
AU  - Korac, Aleksandra
AU  - Golic, Igor
AU  - Perez-Quintanilla, Damian
AU  - Momčilović, Miljana
AU  - Mijatović, Sanja
AU  - Kaluđerović, Goran N.
PY  - 2014
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2205
AB  - The strong therapeutic potential of an organotin(IV) compound loaded in
   nanostructured silica (SBA-15pSn) is demonstrated: B16 melanoma tumor
   growth in syngeneic C57BL/6 mice is almost completely abolished. In
   contrast to apoptosis as the basic mechanism of the anticancer action of
   numerous chemotherapeutics, the important advantage of this SBA-15pSn
   mesoporous material is the induction of cell differentiation, an effect
   unknown for metal-based drugs and nanomaterials alone. This
   non-aggressive mode of drug action is highly efficient against cancer
   cells but is in the concentration range used nontoxic for normal tissue.
   JNK (Jun-amino-terminal kinase)-independent apoptosis accompanied by the
   development of the melanocyte-like nonproliferative phenotype of
   survived cells indicates the extraordinary potential of SBA-15pSn to
   suppress tumor growth without undesirable compensatory proliferation of
   malignant cells in response to neighboring cell death.
T2  - Angewandte Chemie-International Edition
T1  - Organotin(IV)-Loaded Mesoporous Silica as a Biocompatible Strategy in
 Cancer Treatment
IS  - 23
VL  - 53
DO  - 10.1002/anie.201400763
SP  - 5982
EP  - 5987
ER  - 

@article{
author = "Bulatović, Mirna Z. and Maksimović-Ivanić, Danijela and Bensing, Christian and Gomez-Ruiz, Santiago and Steinborn, Dirk and Schmidt, Harry and Mojić, Marija and Korac, Aleksandra and Golic, Igor and Perez-Quintanilla, Damian and Momčilović, Miljana and Mijatović, Sanja and Kaluđerović, Goran N.",
year = "2014",
abstract = "The strong therapeutic potential of an organotin(IV) compound loaded in
   nanostructured silica (SBA-15pSn) is demonstrated: B16 melanoma tumor
   growth in syngeneic C57BL/6 mice is almost completely abolished. In
   contrast to apoptosis as the basic mechanism of the anticancer action of
   numerous chemotherapeutics, the important advantage of this SBA-15pSn
   mesoporous material is the induction of cell differentiation, an effect
   unknown for metal-based drugs and nanomaterials alone. This
   non-aggressive mode of drug action is highly efficient against cancer
   cells but is in the concentration range used nontoxic for normal tissue.
   JNK (Jun-amino-terminal kinase)-independent apoptosis accompanied by the
   development of the melanocyte-like nonproliferative phenotype of
   survived cells indicates the extraordinary potential of SBA-15pSn to
   suppress tumor growth without undesirable compensatory proliferation of
   malignant cells in response to neighboring cell death.",
journal = "Angewandte Chemie-International Edition",
title = "Organotin(IV)-Loaded Mesoporous Silica as a Biocompatible Strategy in
 Cancer Treatment",
number = "23",
volume = "53",
doi = "10.1002/anie.201400763",
pages = "5982-5987"
}

Bulatović, M. Z., Maksimović-Ivanić, D., Bensing, C., Gomez-Ruiz, S., Steinborn, D., Schmidt, H., Mojić, M., Korac, A., Golic, I., Perez-Quintanilla, D., Momčilović, M., Mijatović, S.,& Kaluđerović, G. N.. (2014). Organotin(IV)-Loaded Mesoporous Silica as a Biocompatible Strategy in
 Cancer Treatment. in Angewandte Chemie-International Edition, 53(23), 5982-5987.
https://doi.org/10.1002/anie.201400763

Bulatović MZ, Maksimović-Ivanić D, Bensing C, Gomez-Ruiz S, Steinborn D, Schmidt H, Mojić M, Korac A, Golic I, Perez-Quintanilla D, Momčilović M, Mijatović S, Kaluđerović GN. Organotin(IV)-Loaded Mesoporous Silica as a Biocompatible Strategy in
 Cancer Treatment. in Angewandte Chemie-International Edition. 2014;53(23):5982-5987.
doi:10.1002/anie.201400763 .

Bulatović, Mirna Z., Maksimović-Ivanić, Danijela, Bensing, Christian, Gomez-Ruiz, Santiago, Steinborn, Dirk, Schmidt, Harry, Mojić, Marija, Korac, Aleksandra, Golic, Igor, Perez-Quintanilla, Damian, Momčilović, Miljana, Mijatović, Sanja, Kaluđerović, Goran N., "Organotin(IV)-Loaded Mesoporous Silica as a Biocompatible Strategy in
 Cancer Treatment" in Angewandte Chemie-International Edition, 53, no. 23 (2014):5982-5987,
https://doi.org/10.1002/anie.201400763 . .

TY  - JOUR
AU  - Ludwig, Gerd
AU  - Randelovic, Ivan
AU  - Maksimović-Ivanić, Danijela
AU  - Mijatović, Sanja
AU  - Bulatović, Mirna Z.
AU  - Miljković, Đorđe
AU  - Korb, Marcus
AU  - Lang, Heinrich
AU  - Steinborn, Dirk
AU  - Kaluđerović, Goran N.
PY  - 2014
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2193
AB  - Iridium(III) complexes of the type
   {[}Ir(eta(5)-C5Me5)Cl-2\{Ph2PCH2-CH2CH2S(O)(x)Ph-kappa P\}] (x=0-2; 1-3)
   and {[}Ir(eta(5)-C5Me5)Cl\{Ph2PCH2-CH2CH2S(O)(x)Ph-kappa P,kappa
   S\}]{[}PF6] (x=0-1; 4 and 5) with 3-(diphenyl-phosphino)propyl phenyl
   sulfide, sulfoxide, and sulfone ligands Ph2PCH2CH2CH2S(O)(x)Ph were
   designed, synthesized, and characterized fully, including X-ray
   diffraction analyses for complexes 3 and 4. In vitro studies against
   human thyroid carcinoma (8505C), submandibular carcinoma (A253), breast
   adenocarcinoma (MCF-7), colon adenocarcinoma (SW480), and melano-ma
   (518A2) cell lines provided evidence for the high biological potential
   of the neutral and cationic iridium(III) complexes. Neutral iridium(III)
   complex 5 proved to be the most active, with IC50 values up to about 0.1
   mu m, representing activities of up to one order of magnitude higher
   than cisplatin. Using 8505C cells, apoptosis was shown to be the main
   mechanism through which complex 5 exerts its tumoricidal action. The
   described iridium(III) complexes represent potential leads in the search
   for novel metal-based anticancer agents.
T2  - Chemmedchem
T1  - Anticancer Potential of
 (Pentamethylcyclopentadienyl)chloridoiridium(III) Complexes Bearing
 kappa P and kappa P,kappa S-Coordinated Ph2PCH2CH2CH2S(O)(x)Ph (x=0-2)
 Ligands
IS  - 7
VL  - 9
DO  - 10.1002/cmdc.201300479
SP  - 1586
EP  - 1593
ER  - 

@article{
author = "Ludwig, Gerd and Randelovic, Ivan and Maksimović-Ivanić, Danijela and Mijatović, Sanja and Bulatović, Mirna Z. and Miljković, Đorđe and Korb, Marcus and Lang, Heinrich and Steinborn, Dirk and Kaluđerović, Goran N.",
year = "2014",
abstract = "Iridium(III) complexes of the type
   {[}Ir(eta(5)-C5Me5)Cl-2\{Ph2PCH2-CH2CH2S(O)(x)Ph-kappa P\}] (x=0-2; 1-3)
   and {[}Ir(eta(5)-C5Me5)Cl\{Ph2PCH2-CH2CH2S(O)(x)Ph-kappa P,kappa
   S\}]{[}PF6] (x=0-1; 4 and 5) with 3-(diphenyl-phosphino)propyl phenyl
   sulfide, sulfoxide, and sulfone ligands Ph2PCH2CH2CH2S(O)(x)Ph were
   designed, synthesized, and characterized fully, including X-ray
   diffraction analyses for complexes 3 and 4. In vitro studies against
   human thyroid carcinoma (8505C), submandibular carcinoma (A253), breast
   adenocarcinoma (MCF-7), colon adenocarcinoma (SW480), and melano-ma
   (518A2) cell lines provided evidence for the high biological potential
   of the neutral and cationic iridium(III) complexes. Neutral iridium(III)
   complex 5 proved to be the most active, with IC50 values up to about 0.1
   mu m, representing activities of up to one order of magnitude higher
   than cisplatin. Using 8505C cells, apoptosis was shown to be the main
   mechanism through which complex 5 exerts its tumoricidal action. The
   described iridium(III) complexes represent potential leads in the search
   for novel metal-based anticancer agents.",
journal = "Chemmedchem",
title = "Anticancer Potential of
 (Pentamethylcyclopentadienyl)chloridoiridium(III) Complexes Bearing
 kappa P and kappa P,kappa S-Coordinated Ph2PCH2CH2CH2S(O)(x)Ph (x=0-2)
 Ligands",
number = "7",
volume = "9",
doi = "10.1002/cmdc.201300479",
pages = "1586-1593"
}

Ludwig, G., Randelovic, I., Maksimović-Ivanić, D., Mijatović, S., Bulatović, M. Z., Miljković, Đ., Korb, M., Lang, H., Steinborn, D.,& Kaluđerović, G. N.. (2014). Anticancer Potential of
 (Pentamethylcyclopentadienyl)chloridoiridium(III) Complexes Bearing
 kappa P and kappa P,kappa S-Coordinated Ph2PCH2CH2CH2S(O)(x)Ph (x=0-2)
 Ligands. in Chemmedchem, 9(7), 1586-1593.
https://doi.org/10.1002/cmdc.201300479

Ludwig G, Randelovic I, Maksimović-Ivanić D, Mijatović S, Bulatović MZ, Miljković Đ, Korb M, Lang H, Steinborn D, Kaluđerović GN. Anticancer Potential of
 (Pentamethylcyclopentadienyl)chloridoiridium(III) Complexes Bearing
 kappa P and kappa P,kappa S-Coordinated Ph2PCH2CH2CH2S(O)(x)Ph (x=0-2)
 Ligands. in Chemmedchem. 2014;9(7):1586-1593.
doi:10.1002/cmdc.201300479 .

Ludwig, Gerd, Randelovic, Ivan, Maksimović-Ivanić, Danijela, Mijatović, Sanja, Bulatović, Mirna Z., Miljković, Đorđe, Korb, Marcus, Lang, Heinrich, Steinborn, Dirk, Kaluđerović, Goran N., "Anticancer Potential of
 (Pentamethylcyclopentadienyl)chloridoiridium(III) Complexes Bearing
 kappa P and kappa P,kappa S-Coordinated Ph2PCH2CH2CH2S(O)(x)Ph (x=0-2)
 Ligands" in Chemmedchem, 9, no. 7 (2014):1586-1593,
https://doi.org/10.1002/cmdc.201300479 . .

TY  - JOUR
AU  - Cairović, Aleksandra
AU  - Đorđević, Ivan
AU  - Bulatović, Mirna Z.
AU  - Mojić, Marija
AU  - Momčilović, Miljana
AU  - Stošić-Grujičić, Stanislava
AU  - Maksimović, Vesna M
AU  - Maksimović-Ivanić, Danijela
AU  - Mijatović, Sanja
AU  - Stamenković, Dragoslav S
PY  - 2013
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1022
AB  - The aim of this study was to evaluate the effect of recasting of commercially available Ni-Cr (Wiron 99) and Co-Cr (Dentalit C) dental alloys on physiology of microenvironmental cells. The viability of fibrosarcoma (L929) cells, human embrional fibroblasts (MRC-5) and isolated peripheral blood mononuclear cells (PBMC) was measured by MTT and acidic phosphatase tests. Presence of dying cells was estimated by Annexin/PI staining while the production of intracellular nitric oxide (NO), reactive oxygen (ROS) and nitrogen (RNS) species was determined by DAF-FM diacetate and DHR staining. Recasting of Ni-Cr alloy intensified its cytotoxicity manifested through enhanced free radicals production, induction of cell death and permamently diminished cell proliferation. On the other hand, after initial toxic effect cells adapted to the presence of Co-Cr alloys. Independently of recasting, Co-Cr alloys are more compatible with microenvironment then Ni-Cr alloy. Oppositely, recasting of Ni-Cr alloy promoted its toxicity.
T2  - Digest Journal of Nanomaterials and Biostructures
T1  - In Vitro Assessment of Ni-Cr and Co-Cr Dental Alloys Upon Recasting: Cellular Compatibility
IS  - 2
VL  - 8
SP  - 47
EP  - U461
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1022
ER  - 

@article{
author = "Cairović, Aleksandra and Đorđević, Ivan and Bulatović, Mirna Z. and Mojić, Marija and Momčilović, Miljana and Stošić-Grujičić, Stanislava and Maksimović, Vesna M and Maksimović-Ivanić, Danijela and Mijatović, Sanja and Stamenković, Dragoslav S",
year = "2013",
abstract = "The aim of this study was to evaluate the effect of recasting of commercially available Ni-Cr (Wiron 99) and Co-Cr (Dentalit C) dental alloys on physiology of microenvironmental cells. The viability of fibrosarcoma (L929) cells, human embrional fibroblasts (MRC-5) and isolated peripheral blood mononuclear cells (PBMC) was measured by MTT and acidic phosphatase tests. Presence of dying cells was estimated by Annexin/PI staining while the production of intracellular nitric oxide (NO), reactive oxygen (ROS) and nitrogen (RNS) species was determined by DAF-FM diacetate and DHR staining. Recasting of Ni-Cr alloy intensified its cytotoxicity manifested through enhanced free radicals production, induction of cell death and permamently diminished cell proliferation. On the other hand, after initial toxic effect cells adapted to the presence of Co-Cr alloys. Independently of recasting, Co-Cr alloys are more compatible with microenvironment then Ni-Cr alloy. Oppositely, recasting of Ni-Cr alloy promoted its toxicity.",
journal = "Digest Journal of Nanomaterials and Biostructures",
title = "In Vitro Assessment of Ni-Cr and Co-Cr Dental Alloys Upon Recasting: Cellular Compatibility",
number = "2",
volume = "8",
pages = "47-U461",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1022"
}

Cairović, A., Đorđević, I., Bulatović, M. Z., Mojić, M., Momčilović, M., Stošić-Grujičić, S., Maksimović, V. M., Maksimović-Ivanić, D., Mijatović, S.,& Stamenković, D. S.. (2013). In Vitro Assessment of Ni-Cr and Co-Cr Dental Alloys Upon Recasting: Cellular Compatibility. in Digest Journal of Nanomaterials and Biostructures, 8(2), 47-U461.
https://hdl.handle.net/21.15107/rcub_ibiss_1022

Cairović A, Đorđević I, Bulatović MZ, Mojić M, Momčilović M, Stošić-Grujičić S, Maksimović VM, Maksimović-Ivanić D, Mijatović S, Stamenković DS. In Vitro Assessment of Ni-Cr and Co-Cr Dental Alloys Upon Recasting: Cellular Compatibility. in Digest Journal of Nanomaterials and Biostructures. 2013;8(2):47-U461.
https://hdl.handle.net/21.15107/rcub_ibiss_1022 .

Cairović, Aleksandra, Đorđević, Ivan, Bulatović, Mirna Z., Mojić, Marija, Momčilović, Miljana, Stošić-Grujičić, Stanislava, Maksimović, Vesna M, Maksimović-Ivanić, Danijela, Mijatović, Sanja, Stamenković, Dragoslav S, "In Vitro Assessment of Ni-Cr and Co-Cr Dental Alloys Upon Recasting: Cellular Compatibility" in Digest Journal of Nanomaterials and Biostructures, 8, no. 2 (2013):47-U461,
https://hdl.handle.net/21.15107/rcub_ibiss_1022 .

TY  - JOUR
AU  - Ajdžanović, Vladimir
AU  - Mojić, Marija
AU  - Maksimović-Ivanić, Danijela
AU  - Bulatović, Mirna Z.
AU  - Mijatović, Sanja
AU  - Milošević, Verica
AU  - Spasojević, Ivan B
PY  - 2013
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1024
AB  - Soy isoflavones represent hopeful unconventional remedies in the therapy of prostate cancer. The aim of our study was to determine the effects of genistein and daidzein on the parameters that reflect metastatic potential, membrane fluidity, invasiveness and dynamic phenotype in Matrigel of LNCaP and PC-3 prostate cancer cells. Cell viability tests, using a wide range of concentrations of soy isoflavones (6-75 mu g/ml for 72 h), were conducted to determine their IC50 concentrations. Electron paramagnetic resonance investigations of prostate cancer cell membrane fluidity were performed at IC50 concentrations of genistein and daidzein (12.5 and 25 mu g/ml, respectively, for 10 min). Genistein provoked significant increases in the membrane order parameter (which is reciprocally proportional to membrane fluidity) of 0.722 +/- A 0.006 (LNCaP), 0.753 +/- A 0.010 (LNCaP + genistein), 0.723 +/- A 0.007 (PC-3) and 0.741 +/- A 0.004 (PC-3 + genistein); however, no such effects were observed for daidzein. While both genistein and daidzein reduced the proliferation of prostate cancer cells at their respective IC50 concentrations, during the 72 h of incubation only genistein provoked effects on the dynamic phenotype and decreased invasiveness. The effect was more evident in PC-3 cells compared to LNCaP cells. Our results imply that (1) invasive activity is at least partially dependent on membrane fluidity, (2) genistein may exert its antimetastatic effects by changing the mechanical properties of prostate cancer cells and (3) daidzein should be applied at higher concentrations than genistein in order to achieve pharmacological effects.
T2  - Journal of Membrane Biology
T1  - Membrane Fluidity, Invasiveness and Dynamic Phenotype of Metastatic Prostate Cancer Cells after Treatment with Soy Isoflavones
IS  - 4
VL  - 246
SP  - 145
EP  - 314
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1024
ER  - 

@article{
author = "Ajdžanović, Vladimir and Mojić, Marija and Maksimović-Ivanić, Danijela and Bulatović, Mirna Z. and Mijatović, Sanja and Milošević, Verica and Spasojević, Ivan B",
year = "2013",
abstract = "Soy isoflavones represent hopeful unconventional remedies in the therapy of prostate cancer. The aim of our study was to determine the effects of genistein and daidzein on the parameters that reflect metastatic potential, membrane fluidity, invasiveness and dynamic phenotype in Matrigel of LNCaP and PC-3 prostate cancer cells. Cell viability tests, using a wide range of concentrations of soy isoflavones (6-75 mu g/ml for 72 h), were conducted to determine their IC50 concentrations. Electron paramagnetic resonance investigations of prostate cancer cell membrane fluidity were performed at IC50 concentrations of genistein and daidzein (12.5 and 25 mu g/ml, respectively, for 10 min). Genistein provoked significant increases in the membrane order parameter (which is reciprocally proportional to membrane fluidity) of 0.722 +/- A 0.006 (LNCaP), 0.753 +/- A 0.010 (LNCaP + genistein), 0.723 +/- A 0.007 (PC-3) and 0.741 +/- A 0.004 (PC-3 + genistein); however, no such effects were observed for daidzein. While both genistein and daidzein reduced the proliferation of prostate cancer cells at their respective IC50 concentrations, during the 72 h of incubation only genistein provoked effects on the dynamic phenotype and decreased invasiveness. The effect was more evident in PC-3 cells compared to LNCaP cells. Our results imply that (1) invasive activity is at least partially dependent on membrane fluidity, (2) genistein may exert its antimetastatic effects by changing the mechanical properties of prostate cancer cells and (3) daidzein should be applied at higher concentrations than genistein in order to achieve pharmacological effects.",
journal = "Journal of Membrane Biology",
title = "Membrane Fluidity, Invasiveness and Dynamic Phenotype of Metastatic Prostate Cancer Cells after Treatment with Soy Isoflavones",
number = "4",
volume = "246",
pages = "145-314",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1024"
}

Ajdžanović, V., Mojić, M., Maksimović-Ivanić, D., Bulatović, M. Z., Mijatović, S., Milošević, V.,& Spasojević, I. B.. (2013). Membrane Fluidity, Invasiveness and Dynamic Phenotype of Metastatic Prostate Cancer Cells after Treatment with Soy Isoflavones. in Journal of Membrane Biology, 246(4), 145-314.
https://hdl.handle.net/21.15107/rcub_ibiss_1024

Ajdžanović V, Mojić M, Maksimović-Ivanić D, Bulatović MZ, Mijatović S, Milošević V, Spasojević IB. Membrane Fluidity, Invasiveness and Dynamic Phenotype of Metastatic Prostate Cancer Cells after Treatment with Soy Isoflavones. in Journal of Membrane Biology. 2013;246(4):145-314.
https://hdl.handle.net/21.15107/rcub_ibiss_1024 .

Ajdžanović, Vladimir, Mojić, Marija, Maksimović-Ivanić, Danijela, Bulatović, Mirna Z., Mijatović, Sanja, Milošević, Verica, Spasojević, Ivan B, "Membrane Fluidity, Invasiveness and Dynamic Phenotype of Metastatic Prostate Cancer Cells after Treatment with Soy Isoflavones" in Journal of Membrane Biology, 246, no. 4 (2013):145-314,
https://hdl.handle.net/21.15107/rcub_ibiss_1024 .

TY  - CONF
AU  - Bulatović, Mirna Z.
AU  - Bensing, C
AU  - Miljković, Đorđe
AU  - Mojić, Marija
AU  - Gomez-Ruiz, Santiago
AU  - Mijatović, Sanja
AU  - Maksimović-Ivanić, Danijela
AU  - Kaluđerović, Goran N.
PY  - 2013
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/967
C3  - European Journal of Cancer
T1  - Nanostructured silica functionalized with an organotin compound induces differentiation of B16 melanoma cells
IS  - null
VL  - 49
SP  - 164
EP  - S174
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_967
ER  - 

@conference{
author = "Bulatović, Mirna Z. and Bensing, C and Miljković, Đorđe and Mojić, Marija and Gomez-Ruiz, Santiago and Mijatović, Sanja and Maksimović-Ivanić, Danijela and Kaluđerović, Goran N.",
year = "2013",
journal = "European Journal of Cancer",
title = "Nanostructured silica functionalized with an organotin compound induces differentiation of B16 melanoma cells",
number = "null",
volume = "49",
pages = "164-S174",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_967"
}

Bulatović, M. Z., Bensing, C., Miljković, Đ., Mojić, M., Gomez-Ruiz, S., Mijatović, S., Maksimović-Ivanić, D.,& Kaluđerović, G. N.. (2013). Nanostructured silica functionalized with an organotin compound induces differentiation of B16 melanoma cells. in European Journal of Cancer, 49(null), 164-S174.
https://hdl.handle.net/21.15107/rcub_ibiss_967

Bulatović MZ, Bensing C, Miljković Đ, Mojić M, Gomez-Ruiz S, Mijatović S, Maksimović-Ivanić D, Kaluđerović GN. Nanostructured silica functionalized with an organotin compound induces differentiation of B16 melanoma cells. in European Journal of Cancer. 2013;49(null):164-S174.
https://hdl.handle.net/21.15107/rcub_ibiss_967 .

Bulatović, Mirna Z., Bensing, C, Miljković, Đorđe, Mojić, Marija, Gomez-Ruiz, Santiago, Mijatović, Sanja, Maksimović-Ivanić, Danijela, Kaluđerović, Goran N., "Nanostructured silica functionalized with an organotin compound induces differentiation of B16 melanoma cells" in European Journal of Cancer, 49, no. null (2013):164-S174,
https://hdl.handle.net/21.15107/rcub_ibiss_967 .

TY  - JOUR
AU  - Ludwig, Gerd
AU  - Mijatović, Sanja
AU  - Ranđelović, Ivan
AU  - Bulatović, Mirna Z.
AU  - Miljković, Đorđe
AU  - Maksimović-Ivanić, Danijela
AU  - Korb, Marcus
AU  - Lang, Heinrich
AU  - Steinborn, Dirk
AU  - Kaluđerović, Goran N.
PY  - 2013
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/948
AB  - Neutral iridium(III) complexes of the type [Ir(eta(5)-C5Me5)Cl-2{Ph2PCH2S(O)(x)Ph-kappa P}] (1-3) with diphenylphosphino-functionalized methyl phenyl sulfides, sulfoxides, and sulfones Ph2PCH2S(O)(x)Ph (x = 0, L1; 1, 12; 2, L3) and the cationic complex [Ir(eta(5)-C5Me5)Cl(Ph2PCH2SPh-kappa P,kappa S}][PF6] (4) were synthesized and fully characterized analytically and spectroscopically. Furthermore, the structure of 2 was determined by X-ray diffraction analysis. The biological potential of the neutral and cationic iridium(III) complexes was tested in vitro against the cell lines 8505C, A253, MCF-7, SW480 and 518A2. Complex [Ir(eta(5)-C5Me5)Cl-2{Ph2PCH2S(O)Ph-kappa P}] (2), with ligand L2 kappa P coordinated containing a pendent sulfinyl group, is the most active one (IC50 values of about 3 mu M), thus, with activities comparable to cisplatin. Complex 2 proved to have an even a higher antiproliferative activity than cisplatin against 8505C and SW480 cell lines, used as a model system of highly anaplastic cancers with low sensitivity to conventional chemotherapeutics such as cisplatin. Additional experiments demonstrated that apoptosis and autophagic cell death contribute to the drug's tumoricidal action. (C) 2013 Elsevier Masson SAS. All rights reserved.
T2  - European Journal of Medicinal Chemistry
T1  - Biological activity of neutral and cationic iridium(III) complexes with kappa P and kappa P,kappa S coordinated Ph2PCH2S(O)(x)Ph (x=0-2) ligands
IS  - null
VL  - 69
SP  - 33
EP  - 222
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_948
ER  - 

@article{
author = "Ludwig, Gerd and Mijatović, Sanja and Ranđelović, Ivan and Bulatović, Mirna Z. and Miljković, Đorđe and Maksimović-Ivanić, Danijela and Korb, Marcus and Lang, Heinrich and Steinborn, Dirk and Kaluđerović, Goran N.",
year = "2013",
abstract = "Neutral iridium(III) complexes of the type [Ir(eta(5)-C5Me5)Cl-2{Ph2PCH2S(O)(x)Ph-kappa P}] (1-3) with diphenylphosphino-functionalized methyl phenyl sulfides, sulfoxides, and sulfones Ph2PCH2S(O)(x)Ph (x = 0, L1; 1, 12; 2, L3) and the cationic complex [Ir(eta(5)-C5Me5)Cl(Ph2PCH2SPh-kappa P,kappa S}][PF6] (4) were synthesized and fully characterized analytically and spectroscopically. Furthermore, the structure of 2 was determined by X-ray diffraction analysis. The biological potential of the neutral and cationic iridium(III) complexes was tested in vitro against the cell lines 8505C, A253, MCF-7, SW480 and 518A2. Complex [Ir(eta(5)-C5Me5)Cl-2{Ph2PCH2S(O)Ph-kappa P}] (2), with ligand L2 kappa P coordinated containing a pendent sulfinyl group, is the most active one (IC50 values of about 3 mu M), thus, with activities comparable to cisplatin. Complex 2 proved to have an even a higher antiproliferative activity than cisplatin against 8505C and SW480 cell lines, used as a model system of highly anaplastic cancers with low sensitivity to conventional chemotherapeutics such as cisplatin. Additional experiments demonstrated that apoptosis and autophagic cell death contribute to the drug's tumoricidal action. (C) 2013 Elsevier Masson SAS. All rights reserved.",
journal = "European Journal of Medicinal Chemistry",
title = "Biological activity of neutral and cationic iridium(III) complexes with kappa P and kappa P,kappa S coordinated Ph2PCH2S(O)(x)Ph (x=0-2) ligands",
number = "null",
volume = "69",
pages = "33-222",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_948"
}

Ludwig, G., Mijatović, S., Ranđelović, I., Bulatović, M. Z., Miljković, Đ., Maksimović-Ivanić, D., Korb, M., Lang, H., Steinborn, D.,& Kaluđerović, G. N.. (2013). Biological activity of neutral and cationic iridium(III) complexes with kappa P and kappa P,kappa S coordinated Ph2PCH2S(O)(x)Ph (x=0-2) ligands. in European Journal of Medicinal Chemistry, 69(null), 33-222.
https://hdl.handle.net/21.15107/rcub_ibiss_948

Ludwig G, Mijatović S, Ranđelović I, Bulatović MZ, Miljković Đ, Maksimović-Ivanić D, Korb M, Lang H, Steinborn D, Kaluđerović GN. Biological activity of neutral and cationic iridium(III) complexes with kappa P and kappa P,kappa S coordinated Ph2PCH2S(O)(x)Ph (x=0-2) ligands. in European Journal of Medicinal Chemistry. 2013;69(null):33-222.
https://hdl.handle.net/21.15107/rcub_ibiss_948 .

Ludwig, Gerd, Mijatović, Sanja, Ranđelović, Ivan, Bulatović, Mirna Z., Miljković, Đorđe, Maksimović-Ivanić, Danijela, Korb, Marcus, Lang, Heinrich, Steinborn, Dirk, Kaluđerović, Goran N., "Biological activity of neutral and cationic iridium(III) complexes with kappa P and kappa P,kappa S coordinated Ph2PCH2S(O)(x)Ph (x=0-2) ligands" in European Journal of Medicinal Chemistry, 69, no. null (2013):33-222,
https://hdl.handle.net/21.15107/rcub_ibiss_948 .

TY  - JOUR
AU  - Kaluđerović, Goran N.
AU  - Mijatović, Sanja
AU  - Zmejkovski, Bojana B
AU  - Bulatović, Mirna Z.
AU  - Gomez-Ruiz, Santiago
AU  - Mojić, Marija
AU  - Steinborn, Dirk
AU  - Miljković, Đorđe
AU  - Schmidt, Harry
AU  - Stošić-Grujičić, Stanislava
AU  - Sabo, Tibor J
AU  - Maksimović-Ivanić, Danijela
PY  - 2012
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1223
AB  - Several new R(2)eddp (R = i-Pr, i-Bu; eddp = ethylenediamine-N,N'-di-3-propionate) esters and corresponding platinum(II) and platinum(IV) complexes of the general formula [PtCln(R(2)edda-type)] (n = 2, 4) were synthesized and characterized by spectroscopic methods (IR, H-1 and C-13 NMR) and elemental analysis. The crystal structure of platinum(IV) complex [PtCl4{(c-Pe)(2)eddip}] (3a) was resolved and is given herein. Ligand precursors, platinum(II), and platinum(IV) complexes were tested against eight tumor cell lines (CT26CL25, HTC116, SW620, PC3, LNCaP, U251, A375, and B16). Selectivity in the action of those compounds between tumor and two normal primary cells (fibroblasts and keratinocytes) are discussed. A structure-activity relationship of these compounds is discussed. Furthermore, cell cycle distribution, induction of necrosis, apoptosis, autophagy, anoikis, caspase activation, ROS, and RNS are presented on the cisplatin-resistant colon carcinoma HCT116 cell line.
T2  - Metallomics
T1  - Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells
IS  - 9
VL  - 4
EP  - 987
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1223
ER  - 

@article{
author = "Kaluđerović, Goran N. and Mijatović, Sanja and Zmejkovski, Bojana B and Bulatović, Mirna Z. and Gomez-Ruiz, Santiago and Mojić, Marija and Steinborn, Dirk and Miljković, Đorđe and Schmidt, Harry and Stošić-Grujičić, Stanislava and Sabo, Tibor J and Maksimović-Ivanić, Danijela",
year = "2012",
abstract = "Several new R(2)eddp (R = i-Pr, i-Bu; eddp = ethylenediamine-N,N'-di-3-propionate) esters and corresponding platinum(II) and platinum(IV) complexes of the general formula [PtCln(R(2)edda-type)] (n = 2, 4) were synthesized and characterized by spectroscopic methods (IR, H-1 and C-13 NMR) and elemental analysis. The crystal structure of platinum(IV) complex [PtCl4{(c-Pe)(2)eddip}] (3a) was resolved and is given herein. Ligand precursors, platinum(II), and platinum(IV) complexes were tested against eight tumor cell lines (CT26CL25, HTC116, SW620, PC3, LNCaP, U251, A375, and B16). Selectivity in the action of those compounds between tumor and two normal primary cells (fibroblasts and keratinocytes) are discussed. A structure-activity relationship of these compounds is discussed. Furthermore, cell cycle distribution, induction of necrosis, apoptosis, autophagy, anoikis, caspase activation, ROS, and RNS are presented on the cisplatin-resistant colon carcinoma HCT116 cell line.",
journal = "Metallomics",
title = "Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells",
number = "9",
volume = "4",
pages = "987",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1223"
}

Kaluđerović, G. N., Mijatović, S., Zmejkovski, B. B., Bulatović, M. Z., Gomez-Ruiz, S., Mojić, M., Steinborn, D., Miljković, Đ., Schmidt, H., Stošić-Grujičić, S., Sabo, T. J.,& Maksimović-Ivanić, D.. (2012). Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells. in Metallomics, 4(9).
https://hdl.handle.net/21.15107/rcub_ibiss_1223

Kaluđerović GN, Mijatović S, Zmejkovski BB, Bulatović MZ, Gomez-Ruiz S, Mojić M, Steinborn D, Miljković Đ, Schmidt H, Stošić-Grujičić S, Sabo TJ, Maksimović-Ivanić D. Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells. in Metallomics. 2012;4(9):null-987.
https://hdl.handle.net/21.15107/rcub_ibiss_1223 .

Kaluđerović, Goran N., Mijatović, Sanja, Zmejkovski, Bojana B, Bulatović, Mirna Z., Gomez-Ruiz, Santiago, Mojić, Marija, Steinborn, Dirk, Miljković, Đorđe, Schmidt, Harry, Stošić-Grujičić, Stanislava, Sabo, Tibor J, Maksimović-Ivanić, Danijela, "Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells" in Metallomics, 4, no. 9 (2012),
https://hdl.handle.net/21.15107/rcub_ibiss_1223 .

TY  - JOUR
AU  - Mihajlović, Ljiljana E
AU  - Savić, Aleksandar R
AU  - Poljarević, Jelena M
AU  - Vucković, Ivan M
AU  - Mojić, Marija
AU  - Bulatović, Mirna Z.
AU  - Maksimović-Ivanić, Danijela
AU  - Mijatović, Sanja
AU  - Kaluđerović, Goran N.
AU  - Stošić-Grujičić, Stanislava
AU  - Miljković, Đorđe
AU  - Grgurić-Sipka, Sanja R
AU  - Sabo, Tibor J
PY  - 2012
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1195
AB  - This paper focuses on the synthesis, characterization and biological activity of new N,N'-methylene modified cyclohexyl ethylenediamine-N,N'-diacetate (edda)-type ligands and their Pt(IV) complexes. Both the ligands and complexes were characterized by infrared, UV-vis, ESI-MS, 1D (H-1, C-13, Pt-195) and 2D (COSY, HSQC, HMBC) NMR spectroscopy and elemental analysis. The possible correlation between the reduction potentials and the cytotoxicity of the complexes was examined. The potential antitumoral activity of all compounds was tested in vitro on human melanoma A375, human glioblastoma U251, human prostate cancer PC3, human colon cancer HCT116, mouse melanoma B16 and mouse colon cancer CT26CL25 cells, as well as primary fibroblasts and keratinocytes. The results obtained revealed strong antitumor potential of the newly synthesized drugs with preserved efficacy against cisplatin resistant lines and less toxicity towards nonmalignant counterparts. The mechanism found to be responsible for the observed tumoricidal action of each synthesized compound was induction of apoptosis generally accompanied with caspase activation. Taken together, the effective response to the treatment of a wide range of different cell lines, including cisplatin resistant subclones, as well as induction of apoptosis, as the mechanism suggested to be the most desirable way of eliminating malignant cells, represents a great advantage of this novel group of drugs in comparison to other members in this metallo-drug family. (C) 2012 Elsevier Inc. All rights reserved.
T2  - Journal of Inorganic Biochemistry
T1  - Novel methylene modified cyclohexyl ethylenediamine-N,N '-diacetate ligands and their platinum(IV) complexes. Influence on biological activity
IS  - null
VL  - 109
EP  - 48
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1195
ER  - 

@article{
author = "Mihajlović, Ljiljana E and Savić, Aleksandar R and Poljarević, Jelena M and Vucković, Ivan M and Mojić, Marija and Bulatović, Mirna Z. and Maksimović-Ivanić, Danijela and Mijatović, Sanja and Kaluđerović, Goran N. and Stošić-Grujičić, Stanislava and Miljković, Đorđe and Grgurić-Sipka, Sanja R and Sabo, Tibor J",
year = "2012",
abstract = "This paper focuses on the synthesis, characterization and biological activity of new N,N'-methylene modified cyclohexyl ethylenediamine-N,N'-diacetate (edda)-type ligands and their Pt(IV) complexes. Both the ligands and complexes were characterized by infrared, UV-vis, ESI-MS, 1D (H-1, C-13, Pt-195) and 2D (COSY, HSQC, HMBC) NMR spectroscopy and elemental analysis. The possible correlation between the reduction potentials and the cytotoxicity of the complexes was examined. The potential antitumoral activity of all compounds was tested in vitro on human melanoma A375, human glioblastoma U251, human prostate cancer PC3, human colon cancer HCT116, mouse melanoma B16 and mouse colon cancer CT26CL25 cells, as well as primary fibroblasts and keratinocytes. The results obtained revealed strong antitumor potential of the newly synthesized drugs with preserved efficacy against cisplatin resistant lines and less toxicity towards nonmalignant counterparts. The mechanism found to be responsible for the observed tumoricidal action of each synthesized compound was induction of apoptosis generally accompanied with caspase activation. Taken together, the effective response to the treatment of a wide range of different cell lines, including cisplatin resistant subclones, as well as induction of apoptosis, as the mechanism suggested to be the most desirable way of eliminating malignant cells, represents a great advantage of this novel group of drugs in comparison to other members in this metallo-drug family. (C) 2012 Elsevier Inc. All rights reserved.",
journal = "Journal of Inorganic Biochemistry",
title = "Novel methylene modified cyclohexyl ethylenediamine-N,N '-diacetate ligands and their platinum(IV) complexes. Influence on biological activity",
number = "null",
volume = "109",
pages = "48",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1195"
}

Mihajlović, L. E., Savić, A. R., Poljarević, J. M., Vucković, I. M., Mojić, M., Bulatović, M. Z., Maksimović-Ivanić, D., Mijatović, S., Kaluđerović, G. N., Stošić-Grujičić, S., Miljković, Đ., Grgurić-Sipka, S. R.,& Sabo, T. J.. (2012). Novel methylene modified cyclohexyl ethylenediamine-N,N '-diacetate ligands and their platinum(IV) complexes. Influence on biological activity. in Journal of Inorganic Biochemistry, 109(null).
https://hdl.handle.net/21.15107/rcub_ibiss_1195

Mihajlović LE, Savić AR, Poljarević JM, Vucković IM, Mojić M, Bulatović MZ, Maksimović-Ivanić D, Mijatović S, Kaluđerović GN, Stošić-Grujičić S, Miljković Đ, Grgurić-Sipka SR, Sabo TJ. Novel methylene modified cyclohexyl ethylenediamine-N,N '-diacetate ligands and their platinum(IV) complexes. Influence on biological activity. in Journal of Inorganic Biochemistry. 2012;109(null):null-48.
https://hdl.handle.net/21.15107/rcub_ibiss_1195 .

Mihajlović, Ljiljana E, Savić, Aleksandar R, Poljarević, Jelena M, Vucković, Ivan M, Mojić, Marija, Bulatović, Mirna Z., Maksimović-Ivanić, Danijela, Mijatović, Sanja, Kaluđerović, Goran N., Stošić-Grujičić, Stanislava, Miljković, Đorđe, Grgurić-Sipka, Sanja R, Sabo, Tibor J, "Novel methylene modified cyclohexyl ethylenediamine-N,N '-diacetate ligands and their platinum(IV) complexes. Influence on biological activity" in Journal of Inorganic Biochemistry, 109, no. null (2012),
https://hdl.handle.net/21.15107/rcub_ibiss_1195 .

TY  - CONF
AU  - Mojić, Marija
AU  - Mijatović, Sanja
AU  - Maksimović-Ivanić, Danijela
AU  - Bulatović, Mirna Z.
AU  - Radojković, Milica
AU  - Kuzmanović, Milos B
AU  - Zocca, Mai-Britt
AU  - Al-Abed, Yousef
AU  - Nicoletti, Ferdinando
PY  - 2012
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1117
C3  - Immunology
T1  - Therapeutic potential of Saq-NO in blood cancers
IS  - null
VL  - 137
SP  - 129
EP  - 660
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1117
ER  - 

@conference{
author = "Mojić, Marija and Mijatović, Sanja and Maksimović-Ivanić, Danijela and Bulatović, Mirna Z. and Radojković, Milica and Kuzmanović, Milos B and Zocca, Mai-Britt and Al-Abed, Yousef and Nicoletti, Ferdinando",
year = "2012",
journal = "Immunology",
title = "Therapeutic potential of Saq-NO in blood cancers",
number = "null",
volume = "137",
pages = "129-660",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1117"
}

Mojić, M., Mijatović, S., Maksimović-Ivanić, D., Bulatović, M. Z., Radojković, M., Kuzmanović, M. B., Zocca, M., Al-Abed, Y.,& Nicoletti, F.. (2012). Therapeutic potential of Saq-NO in blood cancers. in Immunology, 137(null), 129-660.
https://hdl.handle.net/21.15107/rcub_ibiss_1117

Mojić M, Mijatović S, Maksimović-Ivanić D, Bulatović MZ, Radojković M, Kuzmanović MB, Zocca M, Al-Abed Y, Nicoletti F. Therapeutic potential of Saq-NO in blood cancers. in Immunology. 2012;137(null):129-660.
https://hdl.handle.net/21.15107/rcub_ibiss_1117 .

Mojić, Marija, Mijatović, Sanja, Maksimović-Ivanić, Danijela, Bulatović, Mirna Z., Radojković, Milica, Kuzmanović, Milos B, Zocca, Mai-Britt, Al-Abed, Yousef, Nicoletti, Ferdinando, "Therapeutic potential of Saq-NO in blood cancers" in Immunology, 137, no. null (2012):129-660,
https://hdl.handle.net/21.15107/rcub_ibiss_1117 .