TY  - JOUR
AU  - Sekulić, Slobodan
AU  - Stilinović, Nebojša
AU  - Baturan, Branislava
AU  - Krsman, Anita
AU  - Tešić, Igor
AU  - Vejnović, Aleksandra
AU  - Petrović, Đorđe
AU  - Nikolašević, Željka
AU  - Mijavec, Anna
AU  - Pešić, Vesna
AU  - Petković, Branka
PY  - 2023
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6057
AB  - Background: Breech presentation (BP) results from at random filling of the intrauterine cavity, with an equal probability for a BP or cephalic presentation (CP). Each fetus in BP has its "pair" in CP randomly assumed CP. Direct comparison of BP and CP makes bias to less expressed differences between these two groups. It is therefore necessary to subtract the number of fetuses/newborns from the CP set that are identical to the number of fetuses/newborns in the BP set, with identical characteristics, and add this group to the BP set before comparing them to the rest of the CP fetuses/newborns in the matching process. Methods: The procedure encompasses nine variables in pregnancies with a congenitally malformed uterus (CMU) identified at the Department of Obstetrics (1985-2014): gestational age, birth mass, birth length, head circumference, shoulders circumference, umbilical length, placental weight, newborn mass/newborn length ratio, and newborn mass/placental mass ratio. Firstly, the probability of BP was determined and its relation to gestational age, physical characteristics, and previous presentations. Then direct comparison as well as case-control matching of the CP and BP were performed. Case-control matching was based on either a single specific variable (M1) or all combined variables (M2). Findings: 462 deliveries were identified with CMU. In 81 cases of multiparity, a fetal presentation was found to be an independent event regardless of the previous presentation, gestational age, and newborn physical characteristics. In four types of CMU with 337 deliveries (Bicornuate, Didelphys, Unicornuate, Arcuate), 9 variables with 36 instances of comparison were observed. M1 in 10 instances and M2 in 6 instances showed a statistically significant lower value of breech/random presentation compared with CP. CP have lower value in 2 instances in M1 and 1 in M2. Statistically significant differences were absent without the matching process. Interpretations: The study confirms the maximum probability for the BP is 50%. The case-control matching procedure shows that it is able to detect the difference between the breech/random presentation and CP, while the classic method of direct comparison was unable to detect any differences. The outcome of the breech/random presentation in CMU should be evaluated with the described case-control matching procedure.
PB  - Lausanne: Frontiers Media SA
T2  - Frontiers in Medicine
T1  - Corrected evaluation of the breech presentation outcome based on etiology of this presentation in congenitally malformed uterus
VL  - 10
DO  - 10.3389/fmed.2023.1160229
SP  - 1160229
ER  - 

@article{
author = "Sekulić, Slobodan and Stilinović, Nebojša and Baturan, Branislava and Krsman, Anita and Tešić, Igor and Vejnović, Aleksandra and Petrović, Đorđe and Nikolašević, Željka and Mijavec, Anna and Pešić, Vesna and Petković, Branka",
year = "2023",
abstract = "Background: Breech presentation (BP) results from at random filling of the intrauterine cavity, with an equal probability for a BP or cephalic presentation (CP). Each fetus in BP has its "pair" in CP randomly assumed CP. Direct comparison of BP and CP makes bias to less expressed differences between these two groups. It is therefore necessary to subtract the number of fetuses/newborns from the CP set that are identical to the number of fetuses/newborns in the BP set, with identical characteristics, and add this group to the BP set before comparing them to the rest of the CP fetuses/newborns in the matching process. Methods: The procedure encompasses nine variables in pregnancies with a congenitally malformed uterus (CMU) identified at the Department of Obstetrics (1985-2014): gestational age, birth mass, birth length, head circumference, shoulders circumference, umbilical length, placental weight, newborn mass/newborn length ratio, and newborn mass/placental mass ratio. Firstly, the probability of BP was determined and its relation to gestational age, physical characteristics, and previous presentations. Then direct comparison as well as case-control matching of the CP and BP were performed. Case-control matching was based on either a single specific variable (M1) or all combined variables (M2). Findings: 462 deliveries were identified with CMU. In 81 cases of multiparity, a fetal presentation was found to be an independent event regardless of the previous presentation, gestational age, and newborn physical characteristics. In four types of CMU with 337 deliveries (Bicornuate, Didelphys, Unicornuate, Arcuate), 9 variables with 36 instances of comparison were observed. M1 in 10 instances and M2 in 6 instances showed a statistically significant lower value of breech/random presentation compared with CP. CP have lower value in 2 instances in M1 and 1 in M2. Statistically significant differences were absent without the matching process. Interpretations: The study confirms the maximum probability for the BP is 50%. The case-control matching procedure shows that it is able to detect the difference between the breech/random presentation and CP, while the classic method of direct comparison was unable to detect any differences. The outcome of the breech/random presentation in CMU should be evaluated with the described case-control matching procedure.",
publisher = "Lausanne: Frontiers Media SA",
journal = "Frontiers in Medicine",
title = "Corrected evaluation of the breech presentation outcome based on etiology of this presentation in congenitally malformed uterus",
volume = "10",
doi = "10.3389/fmed.2023.1160229",
pages = "1160229"
}

Sekulić, S., Stilinović, N., Baturan, B., Krsman, A., Tešić, I., Vejnović, A., Petrović, Đ., Nikolašević, Ž., Mijavec, A., Pešić, V.,& Petković, B.. (2023). Corrected evaluation of the breech presentation outcome based on etiology of this presentation in congenitally malformed uterus. in Frontiers in Medicine
Lausanne: Frontiers Media SA., 10, 1160229.
https://doi.org/10.3389/fmed.2023.1160229

Sekulić S, Stilinović N, Baturan B, Krsman A, Tešić I, Vejnović A, Petrović Đ, Nikolašević Ž, Mijavec A, Pešić V, Petković B. Corrected evaluation of the breech presentation outcome based on etiology of this presentation in congenitally malformed uterus. in Frontiers in Medicine. 2023;10:1160229.
doi:10.3389/fmed.2023.1160229 .

Sekulić, Slobodan, Stilinović, Nebojša, Baturan, Branislava, Krsman, Anita, Tešić, Igor, Vejnović, Aleksandra, Petrović, Đorđe, Nikolašević, Željka, Mijavec, Anna, Pešić, Vesna, Petković, Branka, "Corrected evaluation of the breech presentation outcome based on etiology of this presentation in congenitally malformed uterus" in Frontiers in Medicine, 10 (2023):1160229,
https://doi.org/10.3389/fmed.2023.1160229 . .

TY  - CONF
AU  - Dubljević, Olga
AU  - Pavković, Željko
AU  - Pešić, Vesna
PY  - 2023
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5845
AB  - The molecular mechanisms behind non-motor symptoms of Parkinson’s disease are poorly understood. In literature, the connection between neuroinflammation and depressive symptoms was observed in PD patients, however the implications of such findings are limited due to cerebrospinal fluid and blood derivates being the only obtainable samples for analysis. The aim of this preliminary study was to assess neuroinflammation, memory deficits and depression like symptoms associated with PD and to detect related proinflammatory mediators using a transgenic A53T mouse model. The transgene consists of the human α-synuclein sequence with the A53T mutation driven by the mouse prion protein (PrP) promoter resulting in overexpression of human α-synuclein in key structures associated with PD. Although it was determined that microglial activation is increased in these mice, the specific cytokine profile driving the inflammation has not been characterized in literature. We have examined the expression of three key inflammatory mediators (tumor necrosis factor alpha (TNFα), interleukin-1beta (IL-1β) and interleukin-6 (IL-6) described as markers associated with the microglial pro-inflammatory phenotype in the prefrontal cortex, hippocampus, and striatum of 8 male 6 months old A53T mice. Additionally, depressive like symptoms and anhedonia were assessed using Tail Suspension Test and Sucrose Preference Test respectively, while cognitive status and memory deficits were assessed using Novel Object Recognition Test. Non-transgenic littermates were used as controls. Obtained results depict a characteristic behavioral and pro-inflammatory profile in the transgenic animals. The implications of the obtained findings and the potential for using the A53T model as a tool for studying non-motor features of PD are further discussed.
PB  - Institute for Biological Research "Siniša Stanković" – National Institute of Republic of Serbia, University of Belgrade
C3  - FENS-Hertie Winter School: “Neuro-immune interactions in health and disease”; 2023 Jan 29 - Feb 4; Obergurgl, Austria
T1  - Neuroinflammation associated with non-motor symptoms in Parkinson’s disease- insights from the A53T mouse model
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5845
ER  - 

@conference{
author = "Dubljević, Olga and Pavković, Željko and Pešić, Vesna",
year = "2023",
abstract = "The molecular mechanisms behind non-motor symptoms of Parkinson’s disease are poorly understood. In literature, the connection between neuroinflammation and depressive symptoms was observed in PD patients, however the implications of such findings are limited due to cerebrospinal fluid and blood derivates being the only obtainable samples for analysis. The aim of this preliminary study was to assess neuroinflammation, memory deficits and depression like symptoms associated with PD and to detect related proinflammatory mediators using a transgenic A53T mouse model. The transgene consists of the human α-synuclein sequence with the A53T mutation driven by the mouse prion protein (PrP) promoter resulting in overexpression of human α-synuclein in key structures associated with PD. Although it was determined that microglial activation is increased in these mice, the specific cytokine profile driving the inflammation has not been characterized in literature. We have examined the expression of three key inflammatory mediators (tumor necrosis factor alpha (TNFα), interleukin-1beta (IL-1β) and interleukin-6 (IL-6) described as markers associated with the microglial pro-inflammatory phenotype in the prefrontal cortex, hippocampus, and striatum of 8 male 6 months old A53T mice. Additionally, depressive like symptoms and anhedonia were assessed using Tail Suspension Test and Sucrose Preference Test respectively, while cognitive status and memory deficits were assessed using Novel Object Recognition Test. Non-transgenic littermates were used as controls. Obtained results depict a characteristic behavioral and pro-inflammatory profile in the transgenic animals. The implications of the obtained findings and the potential for using the A53T model as a tool for studying non-motor features of PD are further discussed.",
publisher = "Institute for Biological Research "Siniša Stanković" – National Institute of Republic of Serbia, University of Belgrade",
journal = "FENS-Hertie Winter School: “Neuro-immune interactions in health and disease”; 2023 Jan 29 - Feb 4; Obergurgl, Austria",
title = "Neuroinflammation associated with non-motor symptoms in Parkinson’s disease- insights from the A53T mouse model",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5845"
}

Dubljević, O., Pavković, Ž.,& Pešić, V.. (2023). Neuroinflammation associated with non-motor symptoms in Parkinson’s disease- insights from the A53T mouse model. in FENS-Hertie Winter School: “Neuro-immune interactions in health and disease”; 2023 Jan 29 - Feb 4; Obergurgl, Austria
Institute for Biological Research "Siniša Stanković" – National Institute of Republic of Serbia, University of Belgrade..
https://hdl.handle.net/21.15107/rcub_ibiss_5845

Dubljević O, Pavković Ž, Pešić V. Neuroinflammation associated with non-motor symptoms in Parkinson’s disease- insights from the A53T mouse model. in FENS-Hertie Winter School: “Neuro-immune interactions in health and disease”; 2023 Jan 29 - Feb 4; Obergurgl, Austria. 2023;.
https://hdl.handle.net/21.15107/rcub_ibiss_5845 .

Dubljević, Olga, Pavković, Željko, Pešić, Vesna, "Neuroinflammation associated with non-motor symptoms in Parkinson’s disease- insights from the A53T mouse model" in FENS-Hertie Winter School: “Neuro-immune interactions in health and disease”; 2023 Jan 29 - Feb 4; Obergurgl, Austria (2023),
https://hdl.handle.net/21.15107/rcub_ibiss_5845 .

TY  - CONF
AU  - Dubljević, Olga
AU  - Pavković, Željko
AU  - Pešić, Vesna
PY  - 2023
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5844
AB  - The molecular mechanisms behind non-motor symptoms of Parkinson’s disease are poorly understood. In literature, the connection between neuroinflammation and depressive symptoms was observed in PD patients, however the implications of such findings are limited due to cerebrospinal fluid and blood derivates being the only obtainable samples for analysis. The aim of this preliminary study was to assess neuroinflammation, memory deficits and depression like symptoms associated with PD and to detect related proinflammatory mediators using a transgenic A53T mouse model. The transgene consists of the human α-synuclein sequence with the A53T mutation driven by the mouse prion protein (PrP) promoter resulting in overexpression of human α-synuclein in key structures associated with PD. Although it was determined that microglial activation is increased in these mice, the specific cytokine profile driving the inflammation has not been characterized in literature. We have examined the expression of three key inflammatory mediators (tumor necrosis factor alpha (TNFα), interleukin-1beta (IL-1β) and interleukin-6 (IL-6) described as markers associated with the microglial pro-inflammatory phenotype in the prefrontal cortex, hippocampus, and striatum of 8 male 6 months old A53T mice. Additionally, depressive like symptoms and anhedonia were assessed using Tail Suspension Test and Sucrose Preference Test respectively, while cognitive status and memory deficits were assessed using Novel Object Recognition Test. Non-transgenic littermates were used as controls. Obtained results depict a characteristic behavioral and pro-inflammatory profile in the transgenic animals. The implications of the obtained findings and the potential for using the A53T model as a tool for studying non-motor features of PD are further discussed.
PB  - Federation of European Neuroscience Societies
C3  - FENS-Hertie Winter School: “Neuro-immune interactions in health and disease”; 2023 Jan 29 - Feb 4; Obergurgl, Austria
T1  - Neuroinflammation associated with non-motor symptoms in Parkinson’s disease- insights from the A53T mouse model
SP  - 32
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5844
ER  - 

@conference{
author = "Dubljević, Olga and Pavković, Željko and Pešić, Vesna",
year = "2023",
abstract = "The molecular mechanisms behind non-motor symptoms of Parkinson’s disease are poorly understood. In literature, the connection between neuroinflammation and depressive symptoms was observed in PD patients, however the implications of such findings are limited due to cerebrospinal fluid and blood derivates being the only obtainable samples for analysis. The aim of this preliminary study was to assess neuroinflammation, memory deficits and depression like symptoms associated with PD and to detect related proinflammatory mediators using a transgenic A53T mouse model. The transgene consists of the human α-synuclein sequence with the A53T mutation driven by the mouse prion protein (PrP) promoter resulting in overexpression of human α-synuclein in key structures associated with PD. Although it was determined that microglial activation is increased in these mice, the specific cytokine profile driving the inflammation has not been characterized in literature. We have examined the expression of three key inflammatory mediators (tumor necrosis factor alpha (TNFα), interleukin-1beta (IL-1β) and interleukin-6 (IL-6) described as markers associated with the microglial pro-inflammatory phenotype in the prefrontal cortex, hippocampus, and striatum of 8 male 6 months old A53T mice. Additionally, depressive like symptoms and anhedonia were assessed using Tail Suspension Test and Sucrose Preference Test respectively, while cognitive status and memory deficits were assessed using Novel Object Recognition Test. Non-transgenic littermates were used as controls. Obtained results depict a characteristic behavioral and pro-inflammatory profile in the transgenic animals. The implications of the obtained findings and the potential for using the A53T model as a tool for studying non-motor features of PD are further discussed.",
publisher = "Federation of European Neuroscience Societies",
journal = "FENS-Hertie Winter School: “Neuro-immune interactions in health and disease”; 2023 Jan 29 - Feb 4; Obergurgl, Austria",
title = "Neuroinflammation associated with non-motor symptoms in Parkinson’s disease- insights from the A53T mouse model",
pages = "32",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5844"
}

Dubljević, O., Pavković, Ž.,& Pešić, V.. (2023). Neuroinflammation associated with non-motor symptoms in Parkinson’s disease- insights from the A53T mouse model. in FENS-Hertie Winter School: “Neuro-immune interactions in health and disease”; 2023 Jan 29 - Feb 4; Obergurgl, Austria
Federation of European Neuroscience Societies., 32.
https://hdl.handle.net/21.15107/rcub_ibiss_5844

Dubljević O, Pavković Ž, Pešić V. Neuroinflammation associated with non-motor symptoms in Parkinson’s disease- insights from the A53T mouse model. in FENS-Hertie Winter School: “Neuro-immune interactions in health and disease”; 2023 Jan 29 - Feb 4; Obergurgl, Austria. 2023;:32.
https://hdl.handle.net/21.15107/rcub_ibiss_5844 .

Dubljević, Olga, Pavković, Željko, Pešić, Vesna, "Neuroinflammation associated with non-motor symptoms in Parkinson’s disease- insights from the A53T mouse model" in FENS-Hertie Winter School: “Neuro-immune interactions in health and disease”; 2023 Jan 29 - Feb 4; Obergurgl, Austria (2023):32,
https://hdl.handle.net/21.15107/rcub_ibiss_5844 .

TY  - CONF
AU  - Milovanović, Nikola
AU  - Jovanović Macura, Irena
AU  - Tešić, Vesna
AU  - Pavković, Željko
AU  - Perović, Milka
AU  - Pešić, Vesna
AU  - Ćirić, Jelena
PY  - 2023
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5842
AB  - Alzheimer’s disease (AD) is progressive age-associated brain disorder and the main 
cause of dementia in the elderly worldwide. It is also well-established that the 
prevalence and severity of AD is greater in women than in men, suggesting that sex is 
a crucial variable in disease heterogeneity.
Sex-biased differences in behavioral parameters related to cognition and depressive like behavior were examined in novel, state-of-the-art mouse model of AD-like 
amyloidosis, APPNL-G-F knock-in (KI) mice. Nonspatial and spatial memory were 
assessed using novel object recognition (NOR) and relocation test (NOL), 
respectively, while for depressive-like behavior tail-suspension test (TST) was used. 
Male and female APPNL-G-F mice and their non-APPNL-G-F KI littermates (WT) were 
tested at the age of 9 months.
Memory impairments were evident in both WT and APPNL-G-F females in comparison 
to their male littermates. In NOL as a spatial variation of NOR, the discrimination 
index was decreased, but not in NOR as such. Furthermore, the decrease in total active 
immobility time in TST test was also detected in female WT and APPNL-G-F mice vs. 
male mice suggesting more prominent depressive-like behavior as well. Examined 
parameters had similar pattern in WT and APPNL-G-F mice of both sexes. 
The results suggest prominent sex-biased differences in behavior of males and females 
in this particular model and support its validity for further studies revealing the impact 
of sex to behavioral deficits.
PB  - Belgrade: Serbian Neuroscience Society
C3  - Book of abstracts: 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia
T1  - The impact of sex on behavioral deficits in APP knock-in mouse model of Alzheimer's disease
SP  - 110
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5842
ER  - 

@conference{
author = "Milovanović, Nikola and Jovanović Macura, Irena and Tešić, Vesna and Pavković, Željko and Perović, Milka and Pešić, Vesna and Ćirić, Jelena",
year = "2023",
abstract = "Alzheimer’s disease (AD) is progressive age-associated brain disorder and the main 
cause of dementia in the elderly worldwide. It is also well-established that the 
prevalence and severity of AD is greater in women than in men, suggesting that sex is 
a crucial variable in disease heterogeneity.
Sex-biased differences in behavioral parameters related to cognition and depressive like behavior were examined in novel, state-of-the-art mouse model of AD-like 
amyloidosis, APPNL-G-F knock-in (KI) mice. Nonspatial and spatial memory were 
assessed using novel object recognition (NOR) and relocation test (NOL), 
respectively, while for depressive-like behavior tail-suspension test (TST) was used. 
Male and female APPNL-G-F mice and their non-APPNL-G-F KI littermates (WT) were 
tested at the age of 9 months.
Memory impairments were evident in both WT and APPNL-G-F females in comparison 
to their male littermates. In NOL as a spatial variation of NOR, the discrimination 
index was decreased, but not in NOR as such. Furthermore, the decrease in total active 
immobility time in TST test was also detected in female WT and APPNL-G-F mice vs. 
male mice suggesting more prominent depressive-like behavior as well. Examined 
parameters had similar pattern in WT and APPNL-G-F mice of both sexes. 
The results suggest prominent sex-biased differences in behavior of males and females 
in this particular model and support its validity for further studies revealing the impact 
of sex to behavioral deficits.",
publisher = "Belgrade: Serbian Neuroscience Society",
journal = "Book of abstracts: 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia",
title = "The impact of sex on behavioral deficits in APP knock-in mouse model of Alzheimer's disease",
pages = "110",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5842"
}

Milovanović, N., Jovanović Macura, I., Tešić, V., Pavković, Ž., Perović, M., Pešić, V.,& Ćirić, J.. (2023). The impact of sex on behavioral deficits in APP knock-in mouse model of Alzheimer's disease. in Book of abstracts: 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia
Belgrade: Serbian Neuroscience Society., 110.
https://hdl.handle.net/21.15107/rcub_ibiss_5842

Milovanović N, Jovanović Macura I, Tešić V, Pavković Ž, Perović M, Pešić V, Ćirić J. The impact of sex on behavioral deficits in APP knock-in mouse model of Alzheimer's disease. in Book of abstracts: 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia. 2023;:110.
https://hdl.handle.net/21.15107/rcub_ibiss_5842 .

Milovanović, Nikola, Jovanović Macura, Irena, Tešić, Vesna, Pavković, Željko, Perović, Milka, Pešić, Vesna, Ćirić, Jelena, "The impact of sex on behavioral deficits in APP knock-in mouse model of Alzheimer's disease" in Book of abstracts: 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia (2023):110,
https://hdl.handle.net/21.15107/rcub_ibiss_5842 .

TY  - CONF
AU  - Milovanović, Nikola
AU  - Jovanović Macura, Irena
AU  - Tešić, Vesna
AU  - Pavković, Željko
AU  - Perović, Milka
AU  - Pešić, Vesna
AU  - Ćirić, Jelena
PY  - 2023
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5843
AB  - Alzheimer’s disease (AD) is progressive age-associated brain disorder and the main cause of dementia in the elderly worldwide. It is also well-established that the prevalence and severity of AD is greater in women than in men, suggesting that sex is a crucial variable in disease heterogeneity.Sex-biased differences in behavioral parameters related to cognition and depressive like behavior were examined in novel, state-of-the-art mouse model of AD-like amyloidosis, APPNL-G-F knock-in (KI) mice. Nonspatial and spatial memory were assessed using novel object recognition (NOR) and relocation test (NOL), respectively, while for depressive-like behavior tail-suspension test (TST) was used. Male and female APPNL-G-F mice and their non-APPNL-G-F KI littermates (WT) were tested at the age of 9 months.Memory impairments were evident in both WT and APPNL-G-F females in comparison to their male littermates. In NOL as a spatial variation of NOR, the discrimination index was decreased, but not in NOR as such. Furthermore, the decrease in total active immobility time in TST test was also detected in female WT and APPNL-G-F mice vs. male mice suggesting more prominent depressive-like behavior as well. Examined parameters had similar pattern in WT and APPNL-G-F mice of both sexes. The results suggest prominent sex-biased differences in behavior of males and females in this particular model and support its validity for further studies revealing the impact of sex to behavioral deficits.
PB  - Belgrade: Institute for Biological Research "Siniša Stanković" – National Institute of Republic of Serbia, University of Belgrade
C3  - 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia
T1  - The impact of sex on behavioral deficits in APP knock-in mouse model of Alzheimer's disease
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5843
ER  - 

@conference{
author = "Milovanović, Nikola and Jovanović Macura, Irena and Tešić, Vesna and Pavković, Željko and Perović, Milka and Pešić, Vesna and Ćirić, Jelena",
year = "2023",
abstract = "Alzheimer’s disease (AD) is progressive age-associated brain disorder and the main cause of dementia in the elderly worldwide. It is also well-established that the prevalence and severity of AD is greater in women than in men, suggesting that sex is a crucial variable in disease heterogeneity.Sex-biased differences in behavioral parameters related to cognition and depressive like behavior were examined in novel, state-of-the-art mouse model of AD-like amyloidosis, APPNL-G-F knock-in (KI) mice. Nonspatial and spatial memory were assessed using novel object recognition (NOR) and relocation test (NOL), respectively, while for depressive-like behavior tail-suspension test (TST) was used. Male and female APPNL-G-F mice and their non-APPNL-G-F KI littermates (WT) were tested at the age of 9 months.Memory impairments were evident in both WT and APPNL-G-F females in comparison to their male littermates. In NOL as a spatial variation of NOR, the discrimination index was decreased, but not in NOR as such. Furthermore, the decrease in total active immobility time in TST test was also detected in female WT and APPNL-G-F mice vs. male mice suggesting more prominent depressive-like behavior as well. Examined parameters had similar pattern in WT and APPNL-G-F mice of both sexes. The results suggest prominent sex-biased differences in behavior of males and females in this particular model and support its validity for further studies revealing the impact of sex to behavioral deficits.",
publisher = "Belgrade: Institute for Biological Research "Siniša Stanković" – National Institute of Republic of Serbia, University of Belgrade",
journal = "8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia",
title = "The impact of sex on behavioral deficits in APP knock-in mouse model of Alzheimer's disease",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5843"
}

Milovanović, N., Jovanović Macura, I., Tešić, V., Pavković, Ž., Perović, M., Pešić, V.,& Ćirić, J.. (2023). The impact of sex on behavioral deficits in APP knock-in mouse model of Alzheimer's disease. in 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia
Belgrade: Institute for Biological Research "Siniša Stanković" – National Institute of Republic of Serbia, University of Belgrade..
https://hdl.handle.net/21.15107/rcub_ibiss_5843

Milovanović N, Jovanović Macura I, Tešić V, Pavković Ž, Perović M, Pešić V, Ćirić J. The impact of sex on behavioral deficits in APP knock-in mouse model of Alzheimer's disease. in 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia. 2023;.
https://hdl.handle.net/21.15107/rcub_ibiss_5843 .

Milovanović, Nikola, Jovanović Macura, Irena, Tešić, Vesna, Pavković, Željko, Perović, Milka, Pešić, Vesna, Ćirić, Jelena, "The impact of sex on behavioral deficits in APP knock-in mouse model of Alzheimer's disease" in 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia (2023),
https://hdl.handle.net/21.15107/rcub_ibiss_5843 .

TY  - CONF
AU  - Pavković, Željko
AU  - Potrebić, Milica
AU  - Dubljević, Olga
AU  - Srbovan, Maja
AU  - Pešić, Vesna
PY  - 2023
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5832
AB  - Adolescence is a period when alcohol abuse is more likely to occur. Use of isoflurane
(a volatile anesthetic) in adolescence has been experimentally shown to alter
responses to ethanol, implying that general exposure to anesthetics during adolescence
may be an environmental risk factor contributing to increased susceptibility to alcohol
use disorder (AUD). Our previous work showed that propofol (intravenous anesthetic)
anesthesia exposure (PAE) in adolescence favors risk-taking and preference for
novel/intense stimuli. However, its influence on alcohol consumption hasn’t been
examined. Therefore, we aimed to investigate whether PAE in adolescence alters
alcohol consumption in alcohol-naïve rats.
Male Wistar rats aged 35 and 50 postnatal days (early-to-mid and mid-to-late
adolescence, respectively) were injected with anesthetic dose of propofol emulsion
(75mg/kg) or saline, separated into individual cages and exposed to two-bottle choice
paradigm (allowing free access to food and two bottles, one containing 2,5% ethanol
in 1% sucrose solution and the other containing tap water). Liquid consumption was
measured for 4 constitutive days. Obtained data showed no preference for alcohol in
all analyzed experimental groups. Moreover, the tendency for alcohol intake was
significantly reduced during first 24h after PAE in early-to-mid adolescent rats.
Overall, our study shows that PAE doesn’t increase voluntary alcohol intake in
peripubertal rats used as a rodent model of adolescence. The obtained findings do not
support the view that exposure to general anesthetics in adolescence is a risk factor for
AUD and suggest that a detailed analysis of the range of anesthetics is needed before
generalizing the data.
PB  - Belgrade: Serbian Neuroscience Society
C3  - Book of abstracts: 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia
T1  - Propofol reduces the tendency for alcohol consumption in adolescent rats
SP  - 70
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5832
ER  - 

@conference{
author = "Pavković, Željko and Potrebić, Milica and Dubljević, Olga and Srbovan, Maja and Pešić, Vesna",
year = "2023",
abstract = "Adolescence is a period when alcohol abuse is more likely to occur. Use of isoflurane
(a volatile anesthetic) in adolescence has been experimentally shown to alter
responses to ethanol, implying that general exposure to anesthetics during adolescence
may be an environmental risk factor contributing to increased susceptibility to alcohol
use disorder (AUD). Our previous work showed that propofol (intravenous anesthetic)
anesthesia exposure (PAE) in adolescence favors risk-taking and preference for
novel/intense stimuli. However, its influence on alcohol consumption hasn’t been
examined. Therefore, we aimed to investigate whether PAE in adolescence alters
alcohol consumption in alcohol-naïve rats.
Male Wistar rats aged 35 and 50 postnatal days (early-to-mid and mid-to-late
adolescence, respectively) were injected with anesthetic dose of propofol emulsion
(75mg/kg) or saline, separated into individual cages and exposed to two-bottle choice
paradigm (allowing free access to food and two bottles, one containing 2,5% ethanol
in 1% sucrose solution and the other containing tap water). Liquid consumption was
measured for 4 constitutive days. Obtained data showed no preference for alcohol in
all analyzed experimental groups. Moreover, the tendency for alcohol intake was
significantly reduced during first 24h after PAE in early-to-mid adolescent rats.
Overall, our study shows that PAE doesn’t increase voluntary alcohol intake in
peripubertal rats used as a rodent model of adolescence. The obtained findings do not
support the view that exposure to general anesthetics in adolescence is a risk factor for
AUD and suggest that a detailed analysis of the range of anesthetics is needed before
generalizing the data.",
publisher = "Belgrade: Serbian Neuroscience Society",
journal = "Book of abstracts: 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia",
title = "Propofol reduces the tendency for alcohol consumption in adolescent rats",
pages = "70",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5832"
}

Pavković, Ž., Potrebić, M., Dubljević, O., Srbovan, M.,& Pešić, V.. (2023). Propofol reduces the tendency for alcohol consumption in adolescent rats. in Book of abstracts: 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia
Belgrade: Serbian Neuroscience Society., 70.
https://hdl.handle.net/21.15107/rcub_ibiss_5832

Pavković Ž, Potrebić M, Dubljević O, Srbovan M, Pešić V. Propofol reduces the tendency for alcohol consumption in adolescent rats. in Book of abstracts: 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia. 2023;:70.
https://hdl.handle.net/21.15107/rcub_ibiss_5832 .

Pavković, Željko, Potrebić, Milica, Dubljević, Olga, Srbovan, Maja, Pešić, Vesna, "Propofol reduces the tendency for alcohol consumption in adolescent rats" in Book of abstracts: 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia (2023):70,
https://hdl.handle.net/21.15107/rcub_ibiss_5832 .

TY  - CONF
AU  - Potrebić, Milica
AU  - Pavković, Željko
AU  - Srbovan, Maja
AU  - Dubljević, Olga
AU  - Pešić, Vesna
PY  - 2023
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5831
AB  - Aim: Microglia are macrophages of the brain with a fundamental role in neuronal
homeostasis. Stress-induced activation of microglia leads to rapid morphological
changes and it is implicated that these alternations could mediate different aspects of
early-life stress psychopathologies. We aimed to examine morphological response of
hippocampal microglia to social isolation using peripubertal rats as a rodent model of
adolescence.
Methods: Male peripubertal Wistar rats were randomly selected for group-housing
(GH; n=3 per cage) or single-housing (SH; n=1 per cage) at postnatal day 29. After
1st and 2nd week of defined housing animals῾ brains were sampled, and used for
microglia iba-1 fluorescent labelling and morphology analysis: one filed per section
per animal (n=4 animals per group) in hippocampal dentate gyrus (HDG). Data for
microglia cell shape (FracLac plugin, ImageJ) and cell ramification (Analyze Skeleton
plugin, ImageJ) were collected from single cells in photomicrograph visualized with a
confocal microscope (Leica Microsystems).
Results: Compared to GH peers, SH rats had lower microglial cell density in the HDG
after the 1st week of defined housing, which was not evident after the 2nd week. Other
parameters of microglia shape and ramification showed no difference between the
groups in neither of the two time points examined.
Conclusions: Obtained results showed that change in the cell density in the HDG was
the only and transient change in microglia morphology due to the social isolation
during adolescence. Further examination of other stress-related brain regions is
needed to define in depth the relationship between the microglia phenotype and earlylife
stress conditions.
PB  - Belgrade: Serbian Neuroscience Society
C3  - Book of abstracts: 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia
T1  - Microglial morphological response to the lack of direct social contact in periadolescent rats
SP  - 108
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5831
ER  - 

@conference{
author = "Potrebić, Milica and Pavković, Željko and Srbovan, Maja and Dubljević, Olga and Pešić, Vesna",
year = "2023",
abstract = "Aim: Microglia are macrophages of the brain with a fundamental role in neuronal
homeostasis. Stress-induced activation of microglia leads to rapid morphological
changes and it is implicated that these alternations could mediate different aspects of
early-life stress psychopathologies. We aimed to examine morphological response of
hippocampal microglia to social isolation using peripubertal rats as a rodent model of
adolescence.
Methods: Male peripubertal Wistar rats were randomly selected for group-housing
(GH; n=3 per cage) or single-housing (SH; n=1 per cage) at postnatal day 29. After
1st and 2nd week of defined housing animals῾ brains were sampled, and used for
microglia iba-1 fluorescent labelling and morphology analysis: one filed per section
per animal (n=4 animals per group) in hippocampal dentate gyrus (HDG). Data for
microglia cell shape (FracLac plugin, ImageJ) and cell ramification (Analyze Skeleton
plugin, ImageJ) were collected from single cells in photomicrograph visualized with a
confocal microscope (Leica Microsystems).
Results: Compared to GH peers, SH rats had lower microglial cell density in the HDG
after the 1st week of defined housing, which was not evident after the 2nd week. Other
parameters of microglia shape and ramification showed no difference between the
groups in neither of the two time points examined.
Conclusions: Obtained results showed that change in the cell density in the HDG was
the only and transient change in microglia morphology due to the social isolation
during adolescence. Further examination of other stress-related brain regions is
needed to define in depth the relationship between the microglia phenotype and earlylife
stress conditions.",
publisher = "Belgrade: Serbian Neuroscience Society",
journal = "Book of abstracts: 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia",
title = "Microglial morphological response to the lack of direct social contact in periadolescent rats",
pages = "108",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5831"
}

Potrebić, M., Pavković, Ž., Srbovan, M., Dubljević, O.,& Pešić, V.. (2023). Microglial morphological response to the lack of direct social contact in periadolescent rats. in Book of abstracts: 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia
Belgrade: Serbian Neuroscience Society., 108.
https://hdl.handle.net/21.15107/rcub_ibiss_5831

Potrebić M, Pavković Ž, Srbovan M, Dubljević O, Pešić V. Microglial morphological response to the lack of direct social contact in periadolescent rats. in Book of abstracts: 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia. 2023;:108.
https://hdl.handle.net/21.15107/rcub_ibiss_5831 .

Potrebić, Milica, Pavković, Željko, Srbovan, Maja, Dubljević, Olga, Pešić, Vesna, "Microglial morphological response to the lack of direct social contact in periadolescent rats" in Book of abstracts: 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia (2023):108,
https://hdl.handle.net/21.15107/rcub_ibiss_5831 .

TY  - CONF
AU  - Dubljević, Olga
AU  - Pavković, Željko
AU  - Srbovan, Maja
AU  - Potrebić, Milica
AU  - Pešić, Vesna
PY  - 2023
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5830
AB  - Parkinson's disease (PD) is characterized by both motor and non-motor symptoms.
Current research indicates that neuroinflammation, along with activated glial cells,
represents one of the key factors in the pathogenesis of PD. The aim of this study was
to assess non-motor symptoms of PD as well as the expression of gene markers of
microgliosis, astrogliosis and neuroinflammation in a transgenic A53T mouse model,
which is recommended for studying PD and other synucleinopathies. These transgenic
mice express an A53T missense mutant form of human alpha-synuclein under the
control of the murine prion promoter.
Depression-like symptoms and anhedonia were assessed using Tail Suspension Test
and Sucrose Preference Test respectively, while memory deficits were assessed using
Novel Object Recognition Test along with Object Relocation Test. Gene expression of
ionized calcium-binding adapter molecule (Iba-1), glial fibrillary acidic protein
(GFAP α and δ form) and cytokines associated with the microglial pro-inflammatory
phenotype (TNFα, IL-1β, IL-6) was assessed using RT-PCR. Brain regions of interest
were the prefrontal cortex, hippocampus, and striatum of 6 months old A53T male
mice. Non-transgenic littermates were used as controls. Obtained results suggest that
A53T mice compared to non-transgenic littermates exert 1) the presence of memory
deficits and anhedonia, 2) no difference in the expression of glial activity markers and
pro-inflammatory cytokines in the cortex and striatum, and 3) increased expression of
glial activity markers in the hippocampus, but without significant changes in the
expression of cytokines. Overall, better understanding of the role of active glia in the
model is needed.
PB  - Belgrade: Serbian Neuroscience Society
C3  - Book of abstracts: 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia
T1  - Upregulation of glial markers with absence of a typical proinflammatory profile in the hippocampus of A53T mice as a model of Parkinson’s disease
SP  - 109
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5830
ER  - 

@conference{
author = "Dubljević, Olga and Pavković, Željko and Srbovan, Maja and Potrebić, Milica and Pešić, Vesna",
year = "2023",
abstract = "Parkinson's disease (PD) is characterized by both motor and non-motor symptoms.
Current research indicates that neuroinflammation, along with activated glial cells,
represents one of the key factors in the pathogenesis of PD. The aim of this study was
to assess non-motor symptoms of PD as well as the expression of gene markers of
microgliosis, astrogliosis and neuroinflammation in a transgenic A53T mouse model,
which is recommended for studying PD and other synucleinopathies. These transgenic
mice express an A53T missense mutant form of human alpha-synuclein under the
control of the murine prion promoter.
Depression-like symptoms and anhedonia were assessed using Tail Suspension Test
and Sucrose Preference Test respectively, while memory deficits were assessed using
Novel Object Recognition Test along with Object Relocation Test. Gene expression of
ionized calcium-binding adapter molecule (Iba-1), glial fibrillary acidic protein
(GFAP α and δ form) and cytokines associated with the microglial pro-inflammatory
phenotype (TNFα, IL-1β, IL-6) was assessed using RT-PCR. Brain regions of interest
were the prefrontal cortex, hippocampus, and striatum of 6 months old A53T male
mice. Non-transgenic littermates were used as controls. Obtained results suggest that
A53T mice compared to non-transgenic littermates exert 1) the presence of memory
deficits and anhedonia, 2) no difference in the expression of glial activity markers and
pro-inflammatory cytokines in the cortex and striatum, and 3) increased expression of
glial activity markers in the hippocampus, but without significant changes in the
expression of cytokines. Overall, better understanding of the role of active glia in the
model is needed.",
publisher = "Belgrade: Serbian Neuroscience Society",
journal = "Book of abstracts: 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia",
title = "Upregulation of glial markers with absence of a typical proinflammatory profile in the hippocampus of A53T mice as a model of Parkinson’s disease",
pages = "109",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5830"
}

Dubljević, O., Pavković, Ž., Srbovan, M., Potrebić, M.,& Pešić, V.. (2023). Upregulation of glial markers with absence of a typical proinflammatory profile in the hippocampus of A53T mice as a model of Parkinson’s disease. in Book of abstracts: 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia
Belgrade: Serbian Neuroscience Society., 109.
https://hdl.handle.net/21.15107/rcub_ibiss_5830

Dubljević O, Pavković Ž, Srbovan M, Potrebić M, Pešić V. Upregulation of glial markers with absence of a typical proinflammatory profile in the hippocampus of A53T mice as a model of Parkinson’s disease. in Book of abstracts: 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia. 2023;:109.
https://hdl.handle.net/21.15107/rcub_ibiss_5830 .

Dubljević, Olga, Pavković, Željko, Srbovan, Maja, Potrebić, Milica, Pešić, Vesna, "Upregulation of glial markers with absence of a typical proinflammatory profile in the hippocampus of A53T mice as a model of Parkinson’s disease" in Book of abstracts: 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia (2023):109,
https://hdl.handle.net/21.15107/rcub_ibiss_5830 .

TY  - JOUR
AU  - Milosavljević, Filip
AU  - Brusini, Irene
AU  - Atanasov, Andrea
AU  - Manojlović, Marina
AU  - Vučić, Marija
AU  - Oreščanin-Dušić, Zorana
AU  - Brkljačić, Jelena
AU  - Miljević, Čedo
AU  - Nikolić-Kokić, Aleksandra
AU  - Blagojević, Duško
AU  - Wang, Chunliang
AU  - Damberg, Peter
AU  - Pešić, Vesna
AU  - Tyndale, Rachel F.
AU  - Ingelman-Sundberg, Magnus
AU  - Jukić, Marin M.
PY  - 2023
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5758
AB  - Aims: CYP2C19 transgenic mouse expresses the human CYP2C19 gene in the liver and developing brain, and it exhibits altered neurodevelopment associated with impairments in emotionality and locomotion. Because the validation of new animal models is essential for the understanding of the aetiology and pathophysiology of movement disorders, the objective was to characterise motoric phenotype in CYP2C19 transgenic mice and to investigate its validity as a new animal model of ataxia.

Methods: The rotarod, paw-print and beam-walking tests were utilised to characterise the motoric phenotype. The volumes of 20 brain regions in CYP2C19 transgenic and wild-type mice were quantified by 9.4T gadolinium-enhanced post-mortem structural neuroimaging. Antioxidative enzymatic activity was quantified biochemically. Dopaminergic alterations were characterised by chromatographic quantification of concentrations of dopamine and its metabolites and by subsequent immunohistochemical analyses. The beam-walking test was repeated after the treatment with dopamine receptor antagonists ecopipam and raclopride.

Results: CYP2C19 transgenic mice exhibit abnormal, unilateral ataxia-like gait, clasping reflex and 5.6-fold more paw-slips in the beam-walking test; the motoric phenotype was more pronounced in youth. Transgenic mice exhibited a profound reduction of 12% in cerebellar volume and a moderate reduction of 4% in hippocampal volume; both regions exhibited an increased antioxidative enzyme activity. CYP2C19 mice were hyperdopaminergic; however, the motoric impairment was not ameliorated by dopamine receptor antagonists, and there was no alteration in the number of midbrain dopaminergic neurons in CYP2C19 mice.

Conclusions: Humanised CYP2C19 transgenic mice exhibit altered gait and functional motoric impairments; this phenotype is likely caused by an aberrant cerebellar development.
PB  - Hoboken: Wiley
T2  - Neuropathology and Applied Neurobiology
T1  - The humanised CYP2C19 transgenic mouse exhibits cerebellar atrophy and movement impairment reminiscent of ataxia
IS  - 1
VL  - 49
DO  - 10.1111/nan.12867
SP  - e12867
ER  - 

@article{
author = "Milosavljević, Filip and Brusini, Irene and Atanasov, Andrea and Manojlović, Marina and Vučić, Marija and Oreščanin-Dušić, Zorana and Brkljačić, Jelena and Miljević, Čedo and Nikolić-Kokić, Aleksandra and Blagojević, Duško and Wang, Chunliang and Damberg, Peter and Pešić, Vesna and Tyndale, Rachel F. and Ingelman-Sundberg, Magnus and Jukić, Marin M.",
year = "2023",
abstract = "Aims: CYP2C19 transgenic mouse expresses the human CYP2C19 gene in the liver and developing brain, and it exhibits altered neurodevelopment associated with impairments in emotionality and locomotion. Because the validation of new animal models is essential for the understanding of the aetiology and pathophysiology of movement disorders, the objective was to characterise motoric phenotype in CYP2C19 transgenic mice and to investigate its validity as a new animal model of ataxia.

Methods: The rotarod, paw-print and beam-walking tests were utilised to characterise the motoric phenotype. The volumes of 20 brain regions in CYP2C19 transgenic and wild-type mice were quantified by 9.4T gadolinium-enhanced post-mortem structural neuroimaging. Antioxidative enzymatic activity was quantified biochemically. Dopaminergic alterations were characterised by chromatographic quantification of concentrations of dopamine and its metabolites and by subsequent immunohistochemical analyses. The beam-walking test was repeated after the treatment with dopamine receptor antagonists ecopipam and raclopride.

Results: CYP2C19 transgenic mice exhibit abnormal, unilateral ataxia-like gait, clasping reflex and 5.6-fold more paw-slips in the beam-walking test; the motoric phenotype was more pronounced in youth. Transgenic mice exhibited a profound reduction of 12% in cerebellar volume and a moderate reduction of 4% in hippocampal volume; both regions exhibited an increased antioxidative enzyme activity. CYP2C19 mice were hyperdopaminergic; however, the motoric impairment was not ameliorated by dopamine receptor antagonists, and there was no alteration in the number of midbrain dopaminergic neurons in CYP2C19 mice.

Conclusions: Humanised CYP2C19 transgenic mice exhibit altered gait and functional motoric impairments; this phenotype is likely caused by an aberrant cerebellar development.",
publisher = "Hoboken: Wiley",
journal = "Neuropathology and Applied Neurobiology",
title = "The humanised CYP2C19 transgenic mouse exhibits cerebellar atrophy and movement impairment reminiscent of ataxia",
number = "1",
volume = "49",
doi = "10.1111/nan.12867",
pages = "e12867"
}

Milosavljević, F., Brusini, I., Atanasov, A., Manojlović, M., Vučić, M., Oreščanin-Dušić, Z., Brkljačić, J., Miljević, Č., Nikolić-Kokić, A., Blagojević, D., Wang, C., Damberg, P., Pešić, V., Tyndale, R. F., Ingelman-Sundberg, M.,& Jukić, M. M.. (2023). The humanised CYP2C19 transgenic mouse exhibits cerebellar atrophy and movement impairment reminiscent of ataxia. in Neuropathology and Applied Neurobiology
Hoboken: Wiley., 49(1), e12867.
https://doi.org/10.1111/nan.12867

Milosavljević F, Brusini I, Atanasov A, Manojlović M, Vučić M, Oreščanin-Dušić Z, Brkljačić J, Miljević Č, Nikolić-Kokić A, Blagojević D, Wang C, Damberg P, Pešić V, Tyndale RF, Ingelman-Sundberg M, Jukić MM. The humanised CYP2C19 transgenic mouse exhibits cerebellar atrophy and movement impairment reminiscent of ataxia. in Neuropathology and Applied Neurobiology. 2023;49(1):e12867.
doi:10.1111/nan.12867 .

Milosavljević, Filip, Brusini, Irene, Atanasov, Andrea, Manojlović, Marina, Vučić, Marija, Oreščanin-Dušić, Zorana, Brkljačić, Jelena, Miljević, Čedo, Nikolić-Kokić, Aleksandra, Blagojević, Duško, Wang, Chunliang, Damberg, Peter, Pešić, Vesna, Tyndale, Rachel F., Ingelman-Sundberg, Magnus, Jukić, Marin M., "The humanised CYP2C19 transgenic mouse exhibits cerebellar atrophy and movement impairment reminiscent of ataxia" in Neuropathology and Applied Neurobiology, 49, no. 1 (2023):e12867,
https://doi.org/10.1111/nan.12867 . .

TY  - CONF
AU  - Brkljačić, Jelena
AU  - Veličković, Nataša
AU  - Vojnović-Milutinović, Danijela
AU  - Kovačević, Sanja
AU  - Teofilović, Ana
AU  - Bursać, Biljana
AU  - Pešić, Vesna
AU  - Đorđević, Ana
PY  - 2022
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5710
AB  - Фруктоза је прост шећер одувек присутан у људској исхрани. До 20. века људи су
путем воћа и поврћа уносили релативно ниске количине фруктозе, да би током 20.
века, након увођења високофруктозног кукурузног сирупа у прехрамбену
индустрију, дневни унос фруктозе био учетворостручен што је коинцидирало са
растућом преваленцијом метаболичких поремећаја. Ипак, новије студије показују
да преваленција метаболичких поремећаја и даље расте иако је дневни унос шећера
стабилан или се чак смањује, што указује на допринос других фактора, као што су
смањена физичка активност и свакодневна изложеност стресу. Наша истраживања
на животињском моделу пацова који је храњен фруктозом и хронично излаган
комбинацији стресора пружају одговор на питање да ли, и у којим ситуацијама,
фруктоза може да смањује штетне ефекте стреса, а у којим условима стрес
потенцира штетне ефекте фруктозе? Резултати показују да фруктоза, стрес и
њихова комбинација, на ткивно и полно специфичан начин утичу на метаболизам
глукозе и липида, као и на редокс и инфламаторни статус у јетри, скелетним
мишићима и висцералном масном ткиву, а да поред метаболичких ефеката
фруктоза и стрес утичу и на понашање животиња. Будући да ефекти фруктозе
зависе од дозе и патофизиолошког стања организма, енергија која од ње потиче се
може ефикасно складиштити и по потреби користити кроз физичку активност, док
сталан повећан унос фруктозе, уз седентарни начин живота и стрес може
допринети развоју метаболичких и кардиоваскуларних обољења.
AB  - Fruktoza je prost šećer oduvek prisutan u ljudskoj ishrani. Do 20. veka ljudi su putem voća i povrća unosili relativno niske količine fruktoze, da bi tokom 20. veka, nakon uvođenja visokofruktoznog kukuruznog sirupa u prehrambenu industriju, dnevni unos fruktoze bio učetvorostručen što je koincidiralo sa rastućom prevalencijom metaboličkih poremećaja. Ipak, novije studije pokazuju da prevalencija metaboličkih poremećaja i dalje raste iako je dnevni unos šećera stabilan ili se čak smanjuje, što ukazuje na doprinos drugih faktora, kao što su smanjena fizička aktivnost i svakodnevna izloženost stresu. Naša istraživanja na životinjskom modelu pacova koji je hranjen fruktozom i hronično izlagan kombinaciji stresora pružaju odgovor na pitanje da li, i u kojim situacijama, fruktoza može da smanjuje štetne efekte stresa, a u kojim uslovima stres potencira štetne efekte fruktoze? Rezultati pokazuju da fruktoza, stres i njihova kombinacija, na tkivno i polno specifičan način utiču na metabolizam glukoze i lipida, kao i na redoks i inflamatorni status u jetri, skeletnim mišićima i visceralnom masnom tkivu, a da pored metaboličkih efekata fruktoza i stres utiču i na ponašanje životinja. Budući da efekti fruktoze zavise od doze i patofiziološkog stanja organizma, energija koja od nje potiče se može efikasno skladištiti i po potrebi koristiti kroz fizičku aktivnost, dok stalan povećan unos fruktoze, uz sedentarni način života i stres može doprineti razvoju metaboličkih i kardiovaskularnih oboljenja.
PB  - Belgrade: Serbian Biological Society
C3  - Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia
T1  - Fruktoza u ishrani: Ima li razloga za zabrinutost?
T1  - Фруктоза у исхрани: Има ли разлога за забринутост?
SP  - 284
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5710
ER  - 

@conference{
author = "Brkljačić, Jelena and Veličković, Nataša and Vojnović-Milutinović, Danijela and Kovačević, Sanja and Teofilović, Ana and Bursać, Biljana and Pešić, Vesna and Đorđević, Ana",
year = "2022",
abstract = "Фруктоза је прост шећер одувек присутан у људској исхрани. До 20. века људи су
путем воћа и поврћа уносили релативно ниске количине фруктозе, да би током 20.
века, након увођења високофруктозног кукурузног сирупа у прехрамбену
индустрију, дневни унос фруктозе био учетворостручен што је коинцидирало са
растућом преваленцијом метаболичких поремећаја. Ипак, новије студије показују
да преваленција метаболичких поремећаја и даље расте иако је дневни унос шећера
стабилан или се чак смањује, што указује на допринос других фактора, као што су
смањена физичка активност и свакодневна изложеност стресу. Наша истраживања
на животињском моделу пацова који је храњен фруктозом и хронично излаган
комбинацији стресора пружају одговор на питање да ли, и у којим ситуацијама,
фруктоза може да смањује штетне ефекте стреса, а у којим условима стрес
потенцира штетне ефекте фруктозе? Резултати показују да фруктоза, стрес и
њихова комбинација, на ткивно и полно специфичан начин утичу на метаболизам
глукозе и липида, као и на редокс и инфламаторни статус у јетри, скелетним
мишићима и висцералном масном ткиву, а да поред метаболичких ефеката
фруктоза и стрес утичу и на понашање животиња. Будући да ефекти фруктозе
зависе од дозе и патофизиолошког стања организма, енергија која од ње потиче се
може ефикасно складиштити и по потреби користити кроз физичку активност, док
сталан повећан унос фруктозе, уз седентарни начин живота и стрес може
допринети развоју метаболичких и кардиоваскуларних обољења., Fruktoza je prost šećer oduvek prisutan u ljudskoj ishrani. Do 20. veka ljudi su putem voća i povrća unosili relativno niske količine fruktoze, da bi tokom 20. veka, nakon uvođenja visokofruktoznog kukuruznog sirupa u prehrambenu industriju, dnevni unos fruktoze bio učetvorostručen što je koincidiralo sa rastućom prevalencijom metaboličkih poremećaja. Ipak, novije studije pokazuju da prevalencija metaboličkih poremećaja i dalje raste iako je dnevni unos šećera stabilan ili se čak smanjuje, što ukazuje na doprinos drugih faktora, kao što su smanjena fizička aktivnost i svakodnevna izloženost stresu. Naša istraživanja na životinjskom modelu pacova koji je hranjen fruktozom i hronično izlagan kombinaciji stresora pružaju odgovor na pitanje da li, i u kojim situacijama, fruktoza može da smanjuje štetne efekte stresa, a u kojim uslovima stres potencira štetne efekte fruktoze? Rezultati pokazuju da fruktoza, stres i njihova kombinacija, na tkivno i polno specifičan način utiču na metabolizam glukoze i lipida, kao i na redoks i inflamatorni status u jetri, skeletnim mišićima i visceralnom masnom tkivu, a da pored metaboličkih efekata fruktoza i stres utiču i na ponašanje životinja. Budući da efekti fruktoze zavise od doze i patofiziološkog stanja organizma, energija koja od nje potiče se može efikasno skladištiti i po potrebi koristiti kroz fizičku aktivnost, dok stalan povećan unos fruktoze, uz sedentarni način života i stres može doprineti razvoju metaboličkih i kardiovaskularnih oboljenja.",
publisher = "Belgrade: Serbian Biological Society",
journal = "Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia",
title = "Fruktoza u ishrani: Ima li razloga za zabrinutost?, Фруктоза у исхрани: Има ли разлога за забринутост?",
pages = "284",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5710"
}

Brkljačić, J., Veličković, N., Vojnović-Milutinović, D., Kovačević, S., Teofilović, A., Bursać, B., Pešić, V.,& Đorđević, A.. (2022). Fruktoza u ishrani: Ima li razloga za zabrinutost?. in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia
Belgrade: Serbian Biological Society., 284.
https://hdl.handle.net/21.15107/rcub_ibiss_5710

Brkljačić J, Veličković N, Vojnović-Milutinović D, Kovačević S, Teofilović A, Bursać B, Pešić V, Đorđević A. Fruktoza u ishrani: Ima li razloga za zabrinutost?. in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia. 2022;:284.
https://hdl.handle.net/21.15107/rcub_ibiss_5710 .

Brkljačić, Jelena, Veličković, Nataša, Vojnović-Milutinović, Danijela, Kovačević, Sanja, Teofilović, Ana, Bursać, Biljana, Pešić, Vesna, Đorđević, Ana, "Fruktoza u ishrani: Ima li razloga za zabrinutost?" in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia (2022):284,
https://hdl.handle.net/21.15107/rcub_ibiss_5710 .

TY  - JOUR
AU  - Potrebić, Milica
AU  - Pavković, Željko
AU  - Srbovan, Maja
AU  - Đmura, Goran
AU  - Pešić, Vesna
PY  - 2022
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5336
AB  - Changes in housing density, including individual housing, are commonly necessary in animal research. Obtaining reproducibility and translational validity in biomedical research requires an understanding of how animals adapt to changes in housing density. Existing literature mainly addresses acclimatization after transportation. We used a within-subject design to examine changes in behavior and weight gain of 4-mo-old male Wistar Han rats after reduction of their social group (RSG; due to removal of one rat from a cage containing 3 rats) and social isolation (SI; the removed rat) for the subsequent 2 wk. Changes in weight gain and in exploratory and center-avoidance behavior in an inescapable open arena (OA) were measured before (D0) and on days 7 and 14 (D7 and D14, respectively) after social change. The motor response to d-amphetamine (1.5 mg/kg), which stimulates behavioral arousal in response to novelty, was assessed at D14. Within-subject design revealed that RSG rats in OA had less locomotion at D7 but not more center-avoidance behavior and had returned to the D0 activity level at D14; SI rats in OA had consistently less locomotion and more center-avoidance behavior. Rearing behavior during OA exposure did not change in either group. However, SI rats showed more center-avoidance behavior in OA, greater weight gain, and less amphetamine-induced rearing at D14 as compared with RSG rats. These data indicate that after RSG, mature adult male rats require 2 wk to return to their baseline level of OA-related behavior, while after SI they gain weight and acquire maladaptive exploratory and center-avoidance behavior. The finding that SI produces maladaptive behavioral and physiologic alterations in adult male rats deserves attention because these changes could have confounding effects on research findings.
PB  - Memphis: American Association for Laboratory Animal Science
T2  - Journal of the American Association for Laboratory Animal Science
T1  - Changes in the Behavior and Body Weight of Mature, Adult Male Wistar Han Rats after Reduced Social Grouping and Social Isolation
IS  - 6
VL  - 61
DO  - 10.30802/AALAS-JAALAS-22-000032
SP  - 615
EP  - 623
ER  - 

@article{
author = "Potrebić, Milica and Pavković, Željko and Srbovan, Maja and Đmura, Goran and Pešić, Vesna",
year = "2022",
abstract = "Changes in housing density, including individual housing, are commonly necessary in animal research. Obtaining reproducibility and translational validity in biomedical research requires an understanding of how animals adapt to changes in housing density. Existing literature mainly addresses acclimatization after transportation. We used a within-subject design to examine changes in behavior and weight gain of 4-mo-old male Wistar Han rats after reduction of their social group (RSG; due to removal of one rat from a cage containing 3 rats) and social isolation (SI; the removed rat) for the subsequent 2 wk. Changes in weight gain and in exploratory and center-avoidance behavior in an inescapable open arena (OA) were measured before (D0) and on days 7 and 14 (D7 and D14, respectively) after social change. The motor response to d-amphetamine (1.5 mg/kg), which stimulates behavioral arousal in response to novelty, was assessed at D14. Within-subject design revealed that RSG rats in OA had less locomotion at D7 but not more center-avoidance behavior and had returned to the D0 activity level at D14; SI rats in OA had consistently less locomotion and more center-avoidance behavior. Rearing behavior during OA exposure did not change in either group. However, SI rats showed more center-avoidance behavior in OA, greater weight gain, and less amphetamine-induced rearing at D14 as compared with RSG rats. These data indicate that after RSG, mature adult male rats require 2 wk to return to their baseline level of OA-related behavior, while after SI they gain weight and acquire maladaptive exploratory and center-avoidance behavior. The finding that SI produces maladaptive behavioral and physiologic alterations in adult male rats deserves attention because these changes could have confounding effects on research findings.",
publisher = "Memphis: American Association for Laboratory Animal Science",
journal = "Journal of the American Association for Laboratory Animal Science",
title = "Changes in the Behavior and Body Weight of Mature, Adult Male Wistar Han Rats after Reduced Social Grouping and Social Isolation",
number = "6",
volume = "61",
doi = "10.30802/AALAS-JAALAS-22-000032",
pages = "615-623"
}

Potrebić, M., Pavković, Ž., Srbovan, M., Đmura, G.,& Pešić, V.. (2022). Changes in the Behavior and Body Weight of Mature, Adult Male Wistar Han Rats after Reduced Social Grouping and Social Isolation. in Journal of the American Association for Laboratory Animal Science
Memphis: American Association for Laboratory Animal Science., 61(6), 615-623.
https://doi.org/10.30802/AALAS-JAALAS-22-000032

Potrebić M, Pavković Ž, Srbovan M, Đmura G, Pešić V. Changes in the Behavior and Body Weight of Mature, Adult Male Wistar Han Rats after Reduced Social Grouping and Social Isolation. in Journal of the American Association for Laboratory Animal Science. 2022;61(6):615-623.
doi:10.30802/AALAS-JAALAS-22-000032 .

Potrebić, Milica, Pavković, Željko, Srbovan, Maja, Đmura, Goran, Pešić, Vesna, "Changes in the Behavior and Body Weight of Mature, Adult Male Wistar Han Rats after Reduced Social Grouping and Social Isolation" in Journal of the American Association for Laboratory Animal Science, 61, no. 6 (2022):615-623,
https://doi.org/10.30802/AALAS-JAALAS-22-000032 . .

TY  - JOUR
AU  - Dubljević, Olga
AU  - Ković, Vanja
AU  - Pavković, Željko
AU  - Mitić, Miloš
AU  - Pešić, Vesna
PY  - 2022
UR  - http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC9599889
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5178
AB  - A potential relationship between unrestricted sucrose intake (USI), overweight, and emotional/behavioral control has not been well documented. We examined the influence of USI and having less sweetness than expected on body weight (BW), motor/exploratory, anxiety-like, and social dominant behavior in adult C57BL/6J male mice. Animals had free access to water (group 1) or 32% sucrose and water (sucrose groups 2-5) for 10 days. Then, group 2 remained with 32% sucrose while groups 3-5 were subjected to the downshift (24 h access to 4%, 8%, or 16% sucrose). All experimental groups were weighed and tested in the novel-open arena (NA), elevated plus maze (EPM), and tube tests to assess BW, motor/exploratory, anxiety-like, and social dominance behavior, respectively. USI did not influence animals' BW but produced hyperactivity and anxiolytic-like behavior, which was evident in EPM but not in NA; the outcomes of the downshift were comparable. USI did not influence successes/wins in the tube test but altered emotions that drive the winning, favoring a less anxious behavioral phenotype; this was not evident in the downshifted groups. Observed findings suggest that USI promotes sensation-seeking and motivates dominance, without changing BW, while blunted emotional base of social dominance might be an early mark of the downshift.
PB  - Basel: MDPI
T2  - Brain Sciences
T1  - The Influence of Unlimited Sucrose Intake on Body Weight and Behavior-Findings from a Mouse Model
IS  - 10
VL  - 12
DO  - 10.3390/brainsci12101332
SP  - 1332
ER  - 

@article{
author = "Dubljević, Olga and Ković, Vanja and Pavković, Željko and Mitić, Miloš and Pešić, Vesna",
year = "2022",
abstract = "A potential relationship between unrestricted sucrose intake (USI), overweight, and emotional/behavioral control has not been well documented. We examined the influence of USI and having less sweetness than expected on body weight (BW), motor/exploratory, anxiety-like, and social dominant behavior in adult C57BL/6J male mice. Animals had free access to water (group 1) or 32% sucrose and water (sucrose groups 2-5) for 10 days. Then, group 2 remained with 32% sucrose while groups 3-5 were subjected to the downshift (24 h access to 4%, 8%, or 16% sucrose). All experimental groups were weighed and tested in the novel-open arena (NA), elevated plus maze (EPM), and tube tests to assess BW, motor/exploratory, anxiety-like, and social dominance behavior, respectively. USI did not influence animals' BW but produced hyperactivity and anxiolytic-like behavior, which was evident in EPM but not in NA; the outcomes of the downshift were comparable. USI did not influence successes/wins in the tube test but altered emotions that drive the winning, favoring a less anxious behavioral phenotype; this was not evident in the downshifted groups. Observed findings suggest that USI promotes sensation-seeking and motivates dominance, without changing BW, while blunted emotional base of social dominance might be an early mark of the downshift.",
publisher = "Basel: MDPI",
journal = "Brain Sciences",
title = "The Influence of Unlimited Sucrose Intake on Body Weight and Behavior-Findings from a Mouse Model",
number = "10",
volume = "12",
doi = "10.3390/brainsci12101332",
pages = "1332"
}

Dubljević, O., Ković, V., Pavković, Ž., Mitić, M.,& Pešić, V.. (2022). The Influence of Unlimited Sucrose Intake on Body Weight and Behavior-Findings from a Mouse Model. in Brain Sciences
Basel: MDPI., 12(10), 1332.
https://doi.org/10.3390/brainsci12101332

Dubljević O, Ković V, Pavković Ž, Mitić M, Pešić V. The Influence of Unlimited Sucrose Intake on Body Weight and Behavior-Findings from a Mouse Model. in Brain Sciences. 2022;12(10):1332.
doi:10.3390/brainsci12101332 .

Dubljević, Olga, Ković, Vanja, Pavković, Željko, Mitić, Miloš, Pešić, Vesna, "The Influence of Unlimited Sucrose Intake on Body Weight and Behavior-Findings from a Mouse Model" in Brain Sciences, 12, no. 10 (2022):1332,
https://doi.org/10.3390/brainsci12101332 . .

TY  - JOUR
AU  - Podgorac, Jelena
AU  - Sekulić, Slobodan
AU  - Petković, Branka
AU  - Stojadinović, Gordana
AU  - Martać, Ljiljana
AU  - Pešić, Vesna
PY  - 2022
UR  - http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC9557044
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5169
AB  - Clinical findings show that the use of valproic acid (VPA) during pregnancy increases the risk of birth defects and autism spectrum disorder in offspring. Although there is a consensus that monitoring of potential long-term outcomes of VPA exposure is needed, especially in undiagnosed individuals, preclinical studies addressing this issue are rare. The present study examined the effects of continuous intrauterine exposure to a wide dose range of VPA (50, 100, 200, and 400 mg/kg/day) on the physical and behavioral response in peripubertal mice as a rodent model of adolescence. Body weight and the hot plate test [on postnatal days (PND) 25 and 32], the elevated plus-maze test (on PND35), and the open field test (on PND40) served to examine physical growth, the supraspinal reflex response to a painful thermal stimulus and conditional learning, anxiety-like/risk-assessment behavior, as well as novelty-induced psychomotor activity, respectively. VPA exposure produced the following responses: (i) a negative effect on body weight, except for the dose of 100 mg/kg/day in both sexes; (ii) an increase in the percentage of animals that responded to the thermal stimulus above the defined cut-off time interval and the response latency in both sexes; (iii) dose-specific changes within sexes in behavior provoked by a novel anxiogenic environment, i.e., in females less anxiety-like/risk-assessment behavior in response to the lowest exposure dose, and in males more pronounced anxiety-like/risk-assessment behavior after exposure to the highest dose and 100 mg/kg/day; (iv) dose-specific changes within sexes in novelty-induced psychomotor activity, i.e., in females a decrease in stereotypy-like activity along with an increase in rearing, and in males a decrease in stereotypy-like activity only. These findings show that continuous intrauterine exposure to VPA produces maladaptive functioning in different behavioral domains in adolescence and that the consequences are delicate to assess as they are dose-related within sexes.
PB  - Lausanne: Frontiers Media S.A.
T2  - Frontiers in Behavioral Neuroscience
T1  - The influence of continuous prenatal exposure to valproic acid on physical, nociceptive, emotional and psychomotor responses during adolescence in mice: Dose-related effects within sexes
VL  - 16
DO  - 10.3389/fnbeh.2022.982811
SP  - 982811
ER  - 

@article{
author = "Podgorac, Jelena and Sekulić, Slobodan and Petković, Branka and Stojadinović, Gordana and Martać, Ljiljana and Pešić, Vesna",
year = "2022",
abstract = "Clinical findings show that the use of valproic acid (VPA) during pregnancy increases the risk of birth defects and autism spectrum disorder in offspring. Although there is a consensus that monitoring of potential long-term outcomes of VPA exposure is needed, especially in undiagnosed individuals, preclinical studies addressing this issue are rare. The present study examined the effects of continuous intrauterine exposure to a wide dose range of VPA (50, 100, 200, and 400 mg/kg/day) on the physical and behavioral response in peripubertal mice as a rodent model of adolescence. Body weight and the hot plate test [on postnatal days (PND) 25 and 32], the elevated plus-maze test (on PND35), and the open field test (on PND40) served to examine physical growth, the supraspinal reflex response to a painful thermal stimulus and conditional learning, anxiety-like/risk-assessment behavior, as well as novelty-induced psychomotor activity, respectively. VPA exposure produced the following responses: (i) a negative effect on body weight, except for the dose of 100 mg/kg/day in both sexes; (ii) an increase in the percentage of animals that responded to the thermal stimulus above the defined cut-off time interval and the response latency in both sexes; (iii) dose-specific changes within sexes in behavior provoked by a novel anxiogenic environment, i.e., in females less anxiety-like/risk-assessment behavior in response to the lowest exposure dose, and in males more pronounced anxiety-like/risk-assessment behavior after exposure to the highest dose and 100 mg/kg/day; (iv) dose-specific changes within sexes in novelty-induced psychomotor activity, i.e., in females a decrease in stereotypy-like activity along with an increase in rearing, and in males a decrease in stereotypy-like activity only. These findings show that continuous intrauterine exposure to VPA produces maladaptive functioning in different behavioral domains in adolescence and that the consequences are delicate to assess as they are dose-related within sexes.",
publisher = "Lausanne: Frontiers Media S.A.",
journal = "Frontiers in Behavioral Neuroscience",
title = "The influence of continuous prenatal exposure to valproic acid on physical, nociceptive, emotional and psychomotor responses during adolescence in mice: Dose-related effects within sexes",
volume = "16",
doi = "10.3389/fnbeh.2022.982811",
pages = "982811"
}

Podgorac, J., Sekulić, S., Petković, B., Stojadinović, G., Martać, L.,& Pešić, V.. (2022). The influence of continuous prenatal exposure to valproic acid on physical, nociceptive, emotional and psychomotor responses during adolescence in mice: Dose-related effects within sexes. in Frontiers in Behavioral Neuroscience
Lausanne: Frontiers Media S.A.., 16, 982811.
https://doi.org/10.3389/fnbeh.2022.982811

Podgorac J, Sekulić S, Petković B, Stojadinović G, Martać L, Pešić V. The influence of continuous prenatal exposure to valproic acid on physical, nociceptive, emotional and psychomotor responses during adolescence in mice: Dose-related effects within sexes. in Frontiers in Behavioral Neuroscience. 2022;16:982811.
doi:10.3389/fnbeh.2022.982811 .

Podgorac, Jelena, Sekulić, Slobodan, Petković, Branka, Stojadinović, Gordana, Martać, Ljiljana, Pešić, Vesna, "The influence of continuous prenatal exposure to valproic acid on physical, nociceptive, emotional and psychomotor responses during adolescence in mice: Dose-related effects within sexes" in Frontiers in Behavioral Neuroscience, 16 (2022):982811,
https://doi.org/10.3389/fnbeh.2022.982811 . .

TY  - JOUR
AU  - Potrebić, Milica
AU  - Pavković, Željko
AU  - Puškaš, Nela
AU  - Pešić, Vesna
PY  - 2022
UR  - https://www.frontiersin.org/articles/10.3389/fnbeh.2022.872628/full
UR  - http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC9113078
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/4988
AB  - The fulfillment of belonging needs underlies a variety of behaviors. In order to understand how social needs unmet during maturation shape everyday life, we examined social motivation and cognition in peripubertal rats, as a rodent model of adolescence, subjected to social isolation (SI) during early and early-to-mid adolescence. The behavioral correlates of social orientation (social space preference), sociability (preference for social over non-social novelty), and social novelty preference (SNP) were examined in group-housed (GH) and single-housed (SH) rats in a 3-chamber test. The response to social odors was examined to gain insights into the developmental role of social odors in motivated social behavior. Differentiation between appetitive (number of visits/approaches) and consummatory (exploratory time) aspects of motivated social behavior was done to determine which facet of social motivation characterizes maturation when social needs are met and which aspect dominates when social needs are unsatisfied. The SI-sensitive parvalbumin-expressing interneurons (PVI) in the hippocampus were examined using immunohistochemistry. The main findings are the following: (1) in GH rats, the preference for social space is not evident regardless of animals' age, while sociability becomes apparent in mid-adolescence strictly through consummatory behavior, along with complete SNP (appetitive, consummatory); (2) SH promotes staying in a social chamber/space regardless of animals' age and produces an appetitive preference for it only in early-adolescent animals; (3) SH promotes sociability (appetitive, consummatory) regardless of the animals' age and prevents the SNP; (4) the preference for a social odor is displayed in all the groups through consummatory behavior, while appetitive behavior is evident only in SH rats; (5) the response to social odors does not commensurate directly to the response to conspecifics; (6) SH does not influence PVI in the hippocampus, except in the case of early-adolescence when a transient decrease in the dentate gyrus is observed. These results accentuate the developmental complexity of social motivation and cognition, and the power of SI in adolescence to infringe social maturation at different functional levels, promoting appetitive behavior toward peers overall but harming the interest for social novelty. The findings emphasize the importance of the fulfillment of basic social needs in the navigation through the social world.
PB  - Lausanne: Frontiers Media S.A.
T2  - Frontiers in Behavioral Neuroscience
T1  - The Influence of Social Isolation on Social Orientation, Sociability, Social Novelty Preference, and Hippocampal Parvalbumin-Expressing Interneurons in Peripubertal Rats - Understanding the Importance of Meeting Social Needs in Adolescence.
VL  - 16
DO  - 10.3389/fnbeh.2022.872628
SP  - 872628
ER  - 

@article{
author = "Potrebić, Milica and Pavković, Željko and Puškaš, Nela and Pešić, Vesna",
year = "2022",
abstract = "The fulfillment of belonging needs underlies a variety of behaviors. In order to understand how social needs unmet during maturation shape everyday life, we examined social motivation and cognition in peripubertal rats, as a rodent model of adolescence, subjected to social isolation (SI) during early and early-to-mid adolescence. The behavioral correlates of social orientation (social space preference), sociability (preference for social over non-social novelty), and social novelty preference (SNP) were examined in group-housed (GH) and single-housed (SH) rats in a 3-chamber test. The response to social odors was examined to gain insights into the developmental role of social odors in motivated social behavior. Differentiation between appetitive (number of visits/approaches) and consummatory (exploratory time) aspects of motivated social behavior was done to determine which facet of social motivation characterizes maturation when social needs are met and which aspect dominates when social needs are unsatisfied. The SI-sensitive parvalbumin-expressing interneurons (PVI) in the hippocampus were examined using immunohistochemistry. The main findings are the following: (1) in GH rats, the preference for social space is not evident regardless of animals' age, while sociability becomes apparent in mid-adolescence strictly through consummatory behavior, along with complete SNP (appetitive, consummatory); (2) SH promotes staying in a social chamber/space regardless of animals' age and produces an appetitive preference for it only in early-adolescent animals; (3) SH promotes sociability (appetitive, consummatory) regardless of the animals' age and prevents the SNP; (4) the preference for a social odor is displayed in all the groups through consummatory behavior, while appetitive behavior is evident only in SH rats; (5) the response to social odors does not commensurate directly to the response to conspecifics; (6) SH does not influence PVI in the hippocampus, except in the case of early-adolescence when a transient decrease in the dentate gyrus is observed. These results accentuate the developmental complexity of social motivation and cognition, and the power of SI in adolescence to infringe social maturation at different functional levels, promoting appetitive behavior toward peers overall but harming the interest for social novelty. The findings emphasize the importance of the fulfillment of basic social needs in the navigation through the social world.",
publisher = "Lausanne: Frontiers Media S.A.",
journal = "Frontiers in Behavioral Neuroscience",
title = "The Influence of Social Isolation on Social Orientation, Sociability, Social Novelty Preference, and Hippocampal Parvalbumin-Expressing Interneurons in Peripubertal Rats - Understanding the Importance of Meeting Social Needs in Adolescence.",
volume = "16",
doi = "10.3389/fnbeh.2022.872628",
pages = "872628"
}

Potrebić, M., Pavković, Ž., Puškaš, N.,& Pešić, V.. (2022). The Influence of Social Isolation on Social Orientation, Sociability, Social Novelty Preference, and Hippocampal Parvalbumin-Expressing Interneurons in Peripubertal Rats - Understanding the Importance of Meeting Social Needs in Adolescence.. in Frontiers in Behavioral Neuroscience
Lausanne: Frontiers Media S.A.., 16, 872628.
https://doi.org/10.3389/fnbeh.2022.872628

Potrebić M, Pavković Ž, Puškaš N, Pešić V. The Influence of Social Isolation on Social Orientation, Sociability, Social Novelty Preference, and Hippocampal Parvalbumin-Expressing Interneurons in Peripubertal Rats - Understanding the Importance of Meeting Social Needs in Adolescence.. in Frontiers in Behavioral Neuroscience. 2022;16:872628.
doi:10.3389/fnbeh.2022.872628 .

Potrebić, Milica, Pavković, Željko, Puškaš, Nela, Pešić, Vesna, "The Influence of Social Isolation on Social Orientation, Sociability, Social Novelty Preference, and Hippocampal Parvalbumin-Expressing Interneurons in Peripubertal Rats - Understanding the Importance of Meeting Social Needs in Adolescence." in Frontiers in Behavioral Neuroscience, 16 (2022):872628,
https://doi.org/10.3389/fnbeh.2022.872628 . .

TY  - CONF
AU  - Pavković, Željko
AU  - Potrebić, Milica
AU  - Dubljević, Olga
AU  - Srbovan, Maja
AU  - Pešić, Vesna
PY  - 2022
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5614
AB  - Познато је да су анксиозни поремећаји генерално изражени током адолесценције док специфичности везане за интензитет симптома током различитих фаза адолесценције (рана, средња, касна) још увек нису довољно проучене. Aдолесценција је као период матурације присутна код свих сисара, што оправдава коришћење анималних модела у психобиологији. Имајући у виду дефинисане фазе адолесценције глодара, испитивали смо матурацију експлораторног и анксиозног одговора на новину код мужјака Wistar Han пацова старих 35 ± 1 дан (крај ране/почетак средње адолесценције), 49 ± 1 дан (крај средње/почетак касне адолесценције) и 155 ± 1 дан (адултно доба). Коришћени су тестови у којима животиња слободно истражује нову средину (нова правоугаона арена, црно-бела кутија, уздигнути крстасти лавиринт). Адаптабилност на нову средину је процењивана поређењем бихејвиоралних одговора у првих и последњих 5 минута тестирања. Добијени резултати су показали да код пацова 1) матурациона крива експлораторног одговора на нову средину може имати како линеарни тако и U-профил, у зависности од карактеристика новe средине, 2) понашање налик анксиозном има инвертовани U-профил, док се 3) прилагодљивост независно од срединских услова јавља крајем средње/почетком касне адолесценције. Дискутован је потенцијални значај добијених резултата.
AB  - Poznato je da su anksiozni poremećaji generalno izraženi tokom adolescencije dok specifičnosti vezane za intenzitet simptoma tokom različitih faza adolescencije (rana, srednja, kasna) još uvek nisu dovoljno proučene. Adolescencija je kao period maturacije prisutna kod svih sisara, što opravdava korišćenje animalnih modela u psihobiologiji. Imajući u vidu definisane faze adolescencije glodara, ispitivali smo maturaciju eksploratornog i anksioznog odgovora na novinu kod mužjaka Wistar Han pacova starih 35 ± 1 dan (kraj rane/početak srednje adolescencije), 49 ± 1 dan (kraj srednje/početak kasne adolescencije) i 155 ± 1 dan (adultno doba). Korišćeni su testovi u kojima životinja slobodno istražuje novu sredinu (nova pravougaona arena, crno-bela kutija, uzdignuti krstasti lavirint). Adaptabilnost na novu sredinu je procenjivana poređenjem bihejvioralnih odgovora u prvih i poslednjih 5 minuta testiranja. Dobijeni rezultati su pokazali da kod pacova 1) maturaciona kriva eksploratornog odgovora na novu sredinu može imati kako linearni tako i U-profil, u zavisnosti od karakteristika nove sredine, 2) ponašanje nalik anksioznom ima invertovani U-profil, dok se 3) prilagodljivost nezavisno od sredinskih uslova javlja krajem srednje/početkom kasne adolescencije. Diskutovan je potencijalni značaj dobijenih rezultata.
PB  - Belgrade: Serbian Biological Society
C3  - Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia
T1  - Матурација експлораторног, анксиозног и адаптивног одговора на нове средине у моделу пацова
T1  - Maturacija eksploratornog, anksioznog i adaptivnog odgovora na nove sredine u modelu pacova
SP  - 339
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5614
ER  - 

@conference{
author = "Pavković, Željko and Potrebić, Milica and Dubljević, Olga and Srbovan, Maja and Pešić, Vesna",
year = "2022",
abstract = "Познато је да су анксиозни поремећаји генерално изражени током адолесценције док специфичности везане за интензитет симптома током различитих фаза адолесценције (рана, средња, касна) још увек нису довољно проучене. Aдолесценција је као период матурације присутна код свих сисара, што оправдава коришћење анималних модела у психобиологији. Имајући у виду дефинисане фазе адолесценције глодара, испитивали смо матурацију експлораторног и анксиозног одговора на новину код мужјака Wistar Han пацова старих 35 ± 1 дан (крај ране/почетак средње адолесценције), 49 ± 1 дан (крај средње/почетак касне адолесценције) и 155 ± 1 дан (адултно доба). Коришћени су тестови у којима животиња слободно истражује нову средину (нова правоугаона арена, црно-бела кутија, уздигнути крстасти лавиринт). Адаптабилност на нову средину је процењивана поређењем бихејвиоралних одговора у првих и последњих 5 минута тестирања. Добијени резултати су показали да код пацова 1) матурациона крива експлораторног одговора на нову средину може имати како линеарни тако и U-профил, у зависности од карактеристика новe средине, 2) понашање налик анксиозном има инвертовани U-профил, док се 3) прилагодљивост независно од срединских услова јавља крајем средње/почетком касне адолесценције. Дискутован је потенцијални значај добијених резултата., Poznato je da su anksiozni poremećaji generalno izraženi tokom adolescencije dok specifičnosti vezane za intenzitet simptoma tokom različitih faza adolescencije (rana, srednja, kasna) još uvek nisu dovoljno proučene. Adolescencija je kao period maturacije prisutna kod svih sisara, što opravdava korišćenje animalnih modela u psihobiologiji. Imajući u vidu definisane faze adolescencije glodara, ispitivali smo maturaciju eksploratornog i anksioznog odgovora na novinu kod mužjaka Wistar Han pacova starih 35 ± 1 dan (kraj rane/početak srednje adolescencije), 49 ± 1 dan (kraj srednje/početak kasne adolescencije) i 155 ± 1 dan (adultno doba). Korišćeni su testovi u kojima životinja slobodno istražuje novu sredinu (nova pravougaona arena, crno-bela kutija, uzdignuti krstasti lavirint). Adaptabilnost na novu sredinu je procenjivana poređenjem bihejvioralnih odgovora u prvih i poslednjih 5 minuta testiranja. Dobijeni rezultati su pokazali da kod pacova 1) maturaciona kriva eksploratornog odgovora na novu sredinu može imati kako linearni tako i U-profil, u zavisnosti od karakteristika nove sredine, 2) ponašanje nalik anksioznom ima invertovani U-profil, dok se 3) prilagodljivost nezavisno od sredinskih uslova javlja krajem srednje/početkom kasne adolescencije. Diskutovan je potencijalni značaj dobijenih rezultata.",
publisher = "Belgrade: Serbian Biological Society",
journal = "Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia",
title = "Матурација експлораторног, анксиозног и адаптивног одговора на нове средине у моделу пацова, Maturacija eksploratornog, anksioznog i adaptivnog odgovora na nove sredine u modelu pacova",
pages = "339",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5614"
}

Pavković, Ž., Potrebić, M., Dubljević, O., Srbovan, M.,& Pešić, V.. (2022). Матурација експлораторног, анксиозног и адаптивног одговора на нове средине у моделу пацова. in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia
Belgrade: Serbian Biological Society., 339.
https://hdl.handle.net/21.15107/rcub_ibiss_5614

Pavković Ž, Potrebić M, Dubljević O, Srbovan M, Pešić V. Матурација експлораторног, анксиозног и адаптивног одговора на нове средине у моделу пацова. in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia. 2022;:339.
https://hdl.handle.net/21.15107/rcub_ibiss_5614 .

Pavković, Željko, Potrebić, Milica, Dubljević, Olga, Srbovan, Maja, Pešić, Vesna, "Матурација експлораторног, анксиозног и адаптивног одговора на нове средине у моделу пацова" in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia (2022):339,
https://hdl.handle.net/21.15107/rcub_ibiss_5614 .

TY  - CONF
AU  - Podgorac, Jelena
AU  - Petković, Branka
AU  - Martać, Ljiljana
AU  - Stojadinović, Gordana
AU  - Pešić, Vesna
AU  - Sekulić, Slobodan
PY  - 2022
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5745
AB  - Valproinska kiselina (VPK) je lek izbora u terapiji epilepsija kod trudnica, iako može uzrokovati različite poremećaje kod potomstva.1 Naša prethodna istraživanja su pokazala usporen somatski razvoj i odloženo sazrevanje motoričkog sistema u ranom postnatalnom periodu kod potomaka miševa koji su prenatalno kontinuirano izlagani VPK.2 Sa ciljem da proširimo saznanja vezana za model i procenimo dugotrajnost posledica VPK, u ovoj studiji ispitivali smo karakteristike psihomotornog ponašanja adolescentnih i odraslih mužjaka miševa u odgovoru na novu sredinu. Ženke su kontinuirano injecirane rastvorom VPK (50, 100 ili 400 mg/kg/dan; subkutano) tokom celog perioda gestacije. Potomstvo muškog pola starosti 6 nedelja (adolescenti) i 12 nedelja (odrasli) je ispitivano u testu otvorenog polja (open field test) u cilju procene lokomotorne, stereotipne i vertikalne aktivnosti. Rezultati ukazuju da tretman VPK: (1) nema uticaja na lokomotornu i vertikalnu aktivnost adolescentnih i odraslih jedinki, (2) smanjuje stereotipnu aktivnost adolescentnih jedinki u dozi od 100 i 400 mg/kg/dan. Dobijeni rezultati ukazuju da prenatalno kontinuirano izlaganje VPK ima dugotrajne posledice kod potomstva muškog pola, narušavajući očekivani odgovor adolescentnih jedinki na novu sredinu. Izostanak efekta kod odraslih jedinki se može objasniti spontanim dovođenjem sistema u ravnotežu usled maturacionih promena, što ipak ostaje da se dodatno proceni u drugim testovima zasnovanim na spontanom odgovoru na novu sredinu.
AB  - Валпроинска киселина (ВПК) је лек избора у терапији епилепсија код трудница,
иако може узроковати различите поремећаје код потомства.1 Наша претходна
истраживања су показала успорен соматски развој и одложено сазревање
моторичког система у раном постнаталном периоду код потомака мишева који су
пренатално континуирано излагани ВПК.2 Са циљем да проширимо сазнања везана
за модел и проценимо дуготрајност последица ВПК, у овој студији испитивали смо
карактеристике психомоторног понашања адолесцентних и одраслих мужјака
мишева у одговору на нову средину. Женке су континуирано ињециране раствором
ВПК (50, 100 или 400 мг/кг/дан; субкутано) током целог периода гестације.
Потомство мушког пола старости 6 недеља (адолесценти) и 12 недеља (одрасли) је
испитивано у тесту отвореног поља (open field test) у циљу процене локомоторне,
стереотипне и вертикалне активности. Резултати указују да третман ВПК: (1) нема
утицаја на локомоторну и вертикалну активност адолесцентних и одраслих
јединки, (2) смањује стереотипну активност адолесцентних јединки у дози од 100 и
400 мг/кг/дан. Добијени резултати указују да пренатално континуирано излагање
ВПК има дуготрајне последице код потомства мушког пола, нарушавајући
очекивани одговор адолесцентних јединки на нову средину. Изостанак ефекта код
одраслих јединки се може објаснити спонтаним довођењем система у равнотежу
услед матурационих промена, што ипак остаје да се додатно процени у другим
тестовима заснованим на спонтаном одговору на нову средину.
PB  - Belgrade: Serbian Biological Society
C3  - Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia
T1  - Uticaj kontinuiranog izlaganja valproinskoj kiselini tokom prenatalnog razvoja na psihomotorno ponašanje adolescentnih i odraslih mužjaka miševa
T1  - Утицај континуираног излагања валпроинској киселини током пренаталног развоја на психомоторно понашање адолесцентних и одраслих мужјака мишева
SP  - 369
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5745
ER  - 

@conference{
author = "Podgorac, Jelena and Petković, Branka and Martać, Ljiljana and Stojadinović, Gordana and Pešić, Vesna and Sekulić, Slobodan",
year = "2022",
abstract = "Valproinska kiselina (VPK) je lek izbora u terapiji epilepsija kod trudnica, iako može uzrokovati različite poremećaje kod potomstva.1 Naša prethodna istraživanja su pokazala usporen somatski razvoj i odloženo sazrevanje motoričkog sistema u ranom postnatalnom periodu kod potomaka miševa koji su prenatalno kontinuirano izlagani VPK.2 Sa ciljem da proširimo saznanja vezana za model i procenimo dugotrajnost posledica VPK, u ovoj studiji ispitivali smo karakteristike psihomotornog ponašanja adolescentnih i odraslih mužjaka miševa u odgovoru na novu sredinu. Ženke su kontinuirano injecirane rastvorom VPK (50, 100 ili 400 mg/kg/dan; subkutano) tokom celog perioda gestacije. Potomstvo muškog pola starosti 6 nedelja (adolescenti) i 12 nedelja (odrasli) je ispitivano u testu otvorenog polja (open field test) u cilju procene lokomotorne, stereotipne i vertikalne aktivnosti. Rezultati ukazuju da tretman VPK: (1) nema uticaja na lokomotornu i vertikalnu aktivnost adolescentnih i odraslih jedinki, (2) smanjuje stereotipnu aktivnost adolescentnih jedinki u dozi od 100 i 400 mg/kg/dan. Dobijeni rezultati ukazuju da prenatalno kontinuirano izlaganje VPK ima dugotrajne posledice kod potomstva muškog pola, narušavajući očekivani odgovor adolescentnih jedinki na novu sredinu. Izostanak efekta kod odraslih jedinki se može objasniti spontanim dovođenjem sistema u ravnotežu usled maturacionih promena, što ipak ostaje da se dodatno proceni u drugim testovima zasnovanim na spontanom odgovoru na novu sredinu., Валпроинска киселина (ВПК) је лек избора у терапији епилепсија код трудница,
иако може узроковати различите поремећаје код потомства.1 Наша претходна
истраживања су показала успорен соматски развој и одложено сазревање
моторичког система у раном постнаталном периоду код потомака мишева који су
пренатално континуирано излагани ВПК.2 Са циљем да проширимо сазнања везана
за модел и проценимо дуготрајност последица ВПК, у овој студији испитивали смо
карактеристике психомоторног понашања адолесцентних и одраслих мужјака
мишева у одговору на нову средину. Женке су континуирано ињециране раствором
ВПК (50, 100 или 400 мг/кг/дан; субкутано) током целог периода гестације.
Потомство мушког пола старости 6 недеља (адолесценти) и 12 недеља (одрасли) је
испитивано у тесту отвореног поља (open field test) у циљу процене локомоторне,
стереотипне и вертикалне активности. Резултати указују да третман ВПК: (1) нема
утицаја на локомоторну и вертикалну активност адолесцентних и одраслих
јединки, (2) смањује стереотипну активност адолесцентних јединки у дози од 100 и
400 мг/кг/дан. Добијени резултати указују да пренатално континуирано излагање
ВПК има дуготрајне последице код потомства мушког пола, нарушавајући
очекивани одговор адолесцентних јединки на нову средину. Изостанак ефекта код
одраслих јединки се може објаснити спонтаним довођењем система у равнотежу
услед матурационих промена, што ипак остаје да се додатно процени у другим
тестовима заснованим на спонтаном одговору на нову средину.",
publisher = "Belgrade: Serbian Biological Society",
journal = "Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia",
title = "Uticaj kontinuiranog izlaganja valproinskoj kiselini tokom prenatalnog razvoja na psihomotorno ponašanje adolescentnih i odraslih mužjaka miševa, Утицај континуираног излагања валпроинској киселини током пренаталног развоја на психомоторно понашање адолесцентних и одраслих мужјака мишева",
pages = "369",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5745"
}

Podgorac, J., Petković, B., Martać, L., Stojadinović, G., Pešić, V.,& Sekulić, S.. (2022). Uticaj kontinuiranog izlaganja valproinskoj kiselini tokom prenatalnog razvoja na psihomotorno ponašanje adolescentnih i odraslih mužjaka miševa. in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia
Belgrade: Serbian Biological Society., 369.
https://hdl.handle.net/21.15107/rcub_ibiss_5745

Podgorac J, Petković B, Martać L, Stojadinović G, Pešić V, Sekulić S. Uticaj kontinuiranog izlaganja valproinskoj kiselini tokom prenatalnog razvoja na psihomotorno ponašanje adolescentnih i odraslih mužjaka miševa. in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia. 2022;:369.
https://hdl.handle.net/21.15107/rcub_ibiss_5745 .

Podgorac, Jelena, Petković, Branka, Martać, Ljiljana, Stojadinović, Gordana, Pešić, Vesna, Sekulić, Slobodan, "Uticaj kontinuiranog izlaganja valproinskoj kiselini tokom prenatalnog razvoja na psihomotorno ponašanje adolescentnih i odraslih mužjaka miševa" in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia (2022):369,
https://hdl.handle.net/21.15107/rcub_ibiss_5745 .

TY  - CONF
AU  - Podgorac, Jelena
AU  - Petković, Branka
AU  - Stojadinović, Gordana
AU  - Martać, Ljiljana
AU  - Sekulić, Slobodan
AU  - Pešić, Vesna
PY  - 2022
UR  - https://kenesvm.azureedge.net/public/general/FENS2022.pdf
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5734
AB  - Aims: Levetiracetam (LEV), which belongs to a new generation of antiepileptic drugs, has been recognized as a relatively safe antiepileptic therapy, according to studies on neurodevelopmental outcomes in children exposed to LEV in utero, although some animal studies reported skeletal abnormalities. This study deals with the influence of prenatal exposure to LEV in the doses that cover therapeutic range in humans on gross skeletal structure and anxiety-like behavior in adolescent mice. Methods: Adult 8-weeks old female NMRI mice were randomly divided into four groups and treated subcutaneously during breeding and gestation with saline (control) or LEV in the doses of 158 mg/kg/day (LEV-158), 211 mg/kg/day (LEV-211), or 316 mg/kg/day (LEV-316). After delivery, each female with the progeny was housed separately. Weaning and separation by sex were done on the 20th postnatal day (P20). The elevated plus-maze test was used to assess the anxiety-like behavior in both male and female offspring on P37. Results: Females and males in the LEV-158 and LEV-316 group displayed less anxiety-like behavior compared to the control, while in the LEV-211 group such behavior was not observed. Sex-related differences in anxiety-like behavior were not detected within any LEV group, as well as visible skeletal malformations. Conclusion: The findings in the mouse model suggest that prenatal exposure to LEV could be associated with less anxiety-like behavior in adolescence, paying attention to the U-shaped dose-response and highlighting the behavioral outcomes of small LEV doses.
PB  - Federation of European Neuroscience Societies
C3  - E-Book of Abstracts: FENS Forum 2022; 2022 Jul 9-13; Paris, France
T1  - Anxiety-like behavior in adolescent mice prenatally exposed to different doses of levetiracetam
SP  - S02-173
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5734
ER  - 

@conference{
author = "Podgorac, Jelena and Petković, Branka and Stojadinović, Gordana and Martać, Ljiljana and Sekulić, Slobodan and Pešić, Vesna",
year = "2022",
abstract = "Aims: Levetiracetam (LEV), which belongs to a new generation of antiepileptic drugs, has been recognized as a relatively safe antiepileptic therapy, according to studies on neurodevelopmental outcomes in children exposed to LEV in utero, although some animal studies reported skeletal abnormalities. This study deals with the influence of prenatal exposure to LEV in the doses that cover therapeutic range in humans on gross skeletal structure and anxiety-like behavior in adolescent mice. Methods: Adult 8-weeks old female NMRI mice were randomly divided into four groups and treated subcutaneously during breeding and gestation with saline (control) or LEV in the doses of 158 mg/kg/day (LEV-158), 211 mg/kg/day (LEV-211), or 316 mg/kg/day (LEV-316). After delivery, each female with the progeny was housed separately. Weaning and separation by sex were done on the 20th postnatal day (P20). The elevated plus-maze test was used to assess the anxiety-like behavior in both male and female offspring on P37. Results: Females and males in the LEV-158 and LEV-316 group displayed less anxiety-like behavior compared to the control, while in the LEV-211 group such behavior was not observed. Sex-related differences in anxiety-like behavior were not detected within any LEV group, as well as visible skeletal malformations. Conclusion: The findings in the mouse model suggest that prenatal exposure to LEV could be associated with less anxiety-like behavior in adolescence, paying attention to the U-shaped dose-response and highlighting the behavioral outcomes of small LEV doses.",
publisher = "Federation of European Neuroscience Societies",
journal = "E-Book of Abstracts: FENS Forum 2022; 2022 Jul 9-13; Paris, France",
title = "Anxiety-like behavior in adolescent mice prenatally exposed to different doses of levetiracetam",
pages = "S02-173",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5734"
}

Podgorac, J., Petković, B., Stojadinović, G., Martać, L., Sekulić, S.,& Pešić, V.. (2022). Anxiety-like behavior in adolescent mice prenatally exposed to different doses of levetiracetam. in E-Book of Abstracts: FENS Forum 2022; 2022 Jul 9-13; Paris, France
Federation of European Neuroscience Societies., S02-173.
https://hdl.handle.net/21.15107/rcub_ibiss_5734

Podgorac J, Petković B, Stojadinović G, Martać L, Sekulić S, Pešić V. Anxiety-like behavior in adolescent mice prenatally exposed to different doses of levetiracetam. in E-Book of Abstracts: FENS Forum 2022; 2022 Jul 9-13; Paris, France. 2022;:S02-173.
https://hdl.handle.net/21.15107/rcub_ibiss_5734 .

Podgorac, Jelena, Petković, Branka, Stojadinović, Gordana, Martać, Ljiljana, Sekulić, Slobodan, Pešić, Vesna, "Anxiety-like behavior in adolescent mice prenatally exposed to different doses of levetiracetam" in E-Book of Abstracts: FENS Forum 2022; 2022 Jul 9-13; Paris, France (2022):S02-173,
https://hdl.handle.net/21.15107/rcub_ibiss_5734 .

TY  - CONF
AU  - Milovanović, Nikola
AU  - Jovanović Macura, Irena
AU  - Tešić, Vesna
AU  - Pešić, Vesna
AU  - Hofman, Katarina
AU  - Perović, Milka
AU  - Ćirić, Jelena
PY  - 2022
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5616
AB  - Алцхајмерова болест (АБ) је прогресивно неуродегенеративно обољење које 
карактеришу бројни когнитивни поремећаји и промене у  понашању. Главни је 
узрок деменције код старих особа, а услед пораста просечне старости популације, 
очекује се и да ће број оболелих бити дуплиран у следеће две деценије. У циљу 
разумевања патолошких механизама у основи овог обољења, као и испитивања 
потенцијалних терапијских приступа, развијен је велики број трансгених мишјих 
модела АБ. APPNL-G-F мишеви су „knock-in“ модел АБ новије генерације које 
карактерише присуство хуманог амилоидног прекурсорског протеина (АРР) са три 
мутације које се јављају у  фамилијарном облику болести. Модел карактерише 
убрзан ток патолошких промена, односно депоновање амилоида и појава глиозе 
већ код животиња старих 2 месеца. Да би се окарактерисале ране промене у 
понашању, код мужјака APPNL-G-F мишева  старих 7 месеци и њихових контрола 
дивљег типа из истих окота, испитиване су локомоторна активност и краткотрајна 
меморија. Локомоторна активност је испитивана Тестом отвореног поља, док је 
краткотрајна меморија испитивана Тестом препознавања новог објекта. Додатно, 
један од објеката у тесту отвореног поља је накнадно померан, чинећи тест 
погодним за испитивање краткотрајне визуелне и просторне меморије. Резултати 
су указали на значајне промене у понашању које могу послужити као рани маркери 
когнитивних дефицита у овом моделу.
AB  - Alchajmerova bolest (AB) je progresivno neurodegenerativno oboljenje koje karakterišu brojni kognitivni poremećaji i promene u ponašanju. Glavni je uzrok demencije kod starih osoba, a usled porasta prosečne starosti populacije, očekuje se i da će broj obolelih biti dupliran u sledeće dve decenije. U cilju razumevanja patoloških mehanizama u osnovi ovog oboljenja, kao i ispitivanja potencijalnih terapijskih pristupa, razvijen je veliki broj transgenih mišjih modela AB. APPNL-G-F miševi su „knock-in“ model AB novije generacije koje karakteriše prisustvo humanog amiloidnog prekursorskog proteina (ARR) sa tri mutacije koje se javljaju u familijarnom obliku bolesti. Model karakteriše ubrzan tok patoloških promena, odnosno deponovanje amiloida i pojava glioze već kod životinja starih 2 meseca. Da bi se okarakterisale rane promene u ponašanju, kod mužjaka APPNL-G-F miševa starih 7 meseci i njihovih kontrola divljeg tipa iz istih okota, ispitivane su lokomotorna aktivnost i kratkotrajna memorija. Lokomotorna aktivnost je ispitivana Testom otvorenog polja, dok je kratkotrajna memorija ispitivana Testom prepoznavanja novog objekta. Dodatno, jedan od objekata u testu otvorenog polja je naknadno pomeran, čineći test pogodnim za ispitivanje kratkotrajne vizuelne i prostorne memorije. Rezultati su ukazali na značajne promene u ponašanju koje mogu poslužiti kao rani markeri kognitivnih deficita u ovom modelu.
PB  - Belgrade: Serbian Biological Society
C3  - Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia
T1  - Karakterizacija lokomotorne aktivnosti i kratkotrajne memorije APPNL-G-F miševa kao animalnog modela Alchajmerove bolesti
T1  - Карактеризација локомоторне активности и краткотрајне меморије APPNL-G-F мишева као анималног модела Алцхајмерове болести
SP  - 382
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5616
ER  - 

@conference{
author = "Milovanović, Nikola and Jovanović Macura, Irena and Tešić, Vesna and Pešić, Vesna and Hofman, Katarina and Perović, Milka and Ćirić, Jelena",
year = "2022",
abstract = "Алцхајмерова болест (АБ) је прогресивно неуродегенеративно обољење које 
карактеришу бројни когнитивни поремећаји и промене у  понашању. Главни је 
узрок деменције код старих особа, а услед пораста просечне старости популације, 
очекује се и да ће број оболелих бити дуплиран у следеће две деценије. У циљу 
разумевања патолошких механизама у основи овог обољења, као и испитивања 
потенцијалних терапијских приступа, развијен је велики број трансгених мишјих 
модела АБ. APPNL-G-F мишеви су „knock-in“ модел АБ новије генерације које 
карактерише присуство хуманог амилоидног прекурсорског протеина (АРР) са три 
мутације које се јављају у  фамилијарном облику болести. Модел карактерише 
убрзан ток патолошких промена, односно депоновање амилоида и појава глиозе 
већ код животиња старих 2 месеца. Да би се окарактерисале ране промене у 
понашању, код мужјака APPNL-G-F мишева  старих 7 месеци и њихових контрола 
дивљег типа из истих окота, испитиване су локомоторна активност и краткотрајна 
меморија. Локомоторна активност је испитивана Тестом отвореног поља, док је 
краткотрајна меморија испитивана Тестом препознавања новог објекта. Додатно, 
један од објеката у тесту отвореног поља је накнадно померан, чинећи тест 
погодним за испитивање краткотрајне визуелне и просторне меморије. Резултати 
су указали на значајне промене у понашању које могу послужити као рани маркери 
когнитивних дефицита у овом моделу., Alchajmerova bolest (AB) je progresivno neurodegenerativno oboljenje koje karakterišu brojni kognitivni poremećaji i promene u ponašanju. Glavni je uzrok demencije kod starih osoba, a usled porasta prosečne starosti populacije, očekuje se i da će broj obolelih biti dupliran u sledeće dve decenije. U cilju razumevanja patoloških mehanizama u osnovi ovog oboljenja, kao i ispitivanja potencijalnih terapijskih pristupa, razvijen je veliki broj transgenih mišjih modela AB. APPNL-G-F miševi su „knock-in“ model AB novije generacije koje karakteriše prisustvo humanog amiloidnog prekursorskog proteina (ARR) sa tri mutacije koje se javljaju u familijarnom obliku bolesti. Model karakteriše ubrzan tok patoloških promena, odnosno deponovanje amiloida i pojava glioze već kod životinja starih 2 meseca. Da bi se okarakterisale rane promene u ponašanju, kod mužjaka APPNL-G-F miševa starih 7 meseci i njihovih kontrola divljeg tipa iz istih okota, ispitivane su lokomotorna aktivnost i kratkotrajna memorija. Lokomotorna aktivnost je ispitivana Testom otvorenog polja, dok je kratkotrajna memorija ispitivana Testom prepoznavanja novog objekta. Dodatno, jedan od objekata u testu otvorenog polja je naknadno pomeran, čineći test pogodnim za ispitivanje kratkotrajne vizuelne i prostorne memorije. Rezultati su ukazali na značajne promene u ponašanju koje mogu poslužiti kao rani markeri kognitivnih deficita u ovom modelu.",
publisher = "Belgrade: Serbian Biological Society",
journal = "Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia",
title = "Karakterizacija lokomotorne aktivnosti i kratkotrajne memorije APPNL-G-F miševa kao animalnog modela Alchajmerove bolesti, Карактеризација локомоторне активности и краткотрајне меморије APPNL-G-F мишева као анималног модела Алцхајмерове болести",
pages = "382",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5616"
}

Milovanović, N., Jovanović Macura, I., Tešić, V., Pešić, V., Hofman, K., Perović, M.,& Ćirić, J.. (2022). Karakterizacija lokomotorne aktivnosti i kratkotrajne memorije APPNL-G-F miševa kao animalnog modela Alchajmerove bolesti. in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia
Belgrade: Serbian Biological Society., 382.
https://hdl.handle.net/21.15107/rcub_ibiss_5616

Milovanović N, Jovanović Macura I, Tešić V, Pešić V, Hofman K, Perović M, Ćirić J. Karakterizacija lokomotorne aktivnosti i kratkotrajne memorije APPNL-G-F miševa kao animalnog modela Alchajmerove bolesti. in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia. 2022;:382.
https://hdl.handle.net/21.15107/rcub_ibiss_5616 .

Milovanović, Nikola, Jovanović Macura, Irena, Tešić, Vesna, Pešić, Vesna, Hofman, Katarina, Perović, Milka, Ćirić, Jelena, "Karakterizacija lokomotorne aktivnosti i kratkotrajne memorije APPNL-G-F miševa kao animalnog modela Alchajmerove bolesti" in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia (2022):382,
https://hdl.handle.net/21.15107/rcub_ibiss_5616 .

TY  - CONF
AU  - Dubljević, Olga
AU  - Ković, Vanja
AU  - Pavković, Željko
AU  - Mitić, Miloš
AU  - Pešić, Vesna
PY  - 2022
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5617
AB  - Већина доступних животињских модела зависности од шећера не укључује компоненту само-администрирања супстанце, а познато је да се код људи конзумирање шећера одвија у ad libitum условима. Како би превазишли овај проблем, у овој студији испитани су конзуматорни и бихевиорални исходи неограниченог уноса шећера, као и накнадног смањења доступности шећера код адултних мужјака C57BL/6J мишева применом модификоване парадигме „Конзуматорни сукцесивни негативни контраст“ (cSNC).1,2 Две групе животиња имале су неограничен приступ 32% раствору сахарозе 10 дана (у виду тзв. Two- Bottle-Choice протокола); 11. дана једна група добила је раствор са мањом концентрацијом сахарозе (32%→4%), док је друга група добила уобичајени 32% раствор. Контролна група је имала ad libitum приступ води. Дванаестог дана стандардизованим тестовима понашања (Тест отвореног поља, Крстасти лавиринт и Туба тест социјалне конфронтације) испитани су социјална доминација, као и новином-изазвано експлораторно и понашање слично анксиозности. Добијени резултати указују на централни утицај неограниченог уноса шећера с обзиром да је код C57BL/6J мужјака уочен анксиолитички ефекат на понашање који вероватно одражава физиолошку дисрегулацију и склоност тражењу сензација. Потенцијални простор за примену нове модификоване парадигме у испитивању патолошких последица неограниченог уноса шећера даље је размотрен.
AB  - Većina dostupnih životinjskih modela zavisnosti od šećera ne uključuje komponentu samo-administriranja supstance, a poznato je da se kod ljudi konzumiranje šećera odvija u ad libitum uslovima. Kako bi prevazišli ovaj problem, u ovoj studiji ispitani su konzumatorni i bihevioralni ishodi neograničenog unosa šećera, kao i naknadnog smanjenja dostupnosti šećera kod adultnih mužjaka C57BL/6J miševa primenom modifikovane paradigme „Konzumatorni sukcesivni negativni kontrast“ (cSNC).1,2 Dve grupe životinja imale su neograničen pristup 32% rastvoru saharoze 10 dana (u vidu tzv. Two- Bottle-Choice protokola); 11. dana jedna grupa dobila je rastvor sa manjom koncentracijom saharoze (32%→4%), dok je druga grupa dobila uobičajeni 32% rastvor. Kontrolna grupa je imala ad libitum pristup vodi. Dvanaestog dana standardizovanim testovima ponašanja (Test otvorenog polja, Krstasti lavirint i Tuba test socijalne konfrontacije) ispitani su socijalna dominacija, kao i novinom-izazvano eksploratorno i ponašanje slično anksioznosti. Dobijeni rezultati ukazuju na centralni uticaj neograničenog unosa šećera s obzirom da je kod C57BL/6J mužjaka uočen anksiolitički efekat na ponašanje koji verovatno odražava fiziološku disregulaciju i sklonost traženju senzacija. Potencijalni prostor za primenu nove modifikovane paradigme u ispitivanju patoloških posledica neograničenog unosa šećera dalje je razmotren.
PB  - Belgrade: Serbian Biological Society
C3  - Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia
T1  - Конзуматорне и бихевиоралне последице неограниченог уноса шећера и  накнадног смањења доступности шећера
T1  - Konzumatorne i bihevioralne posledice neograničenog unosa šećera i naknadnog smanjenja dostupnosti šećera
SP  - 384
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5617
ER  - 

@conference{
author = "Dubljević, Olga and Ković, Vanja and Pavković, Željko and Mitić, Miloš and Pešić, Vesna",
year = "2022",
abstract = "Већина доступних животињских модела зависности од шећера не укључује компоненту само-администрирања супстанце, а познато је да се код људи конзумирање шећера одвија у ad libitum условима. Како би превазишли овај проблем, у овој студији испитани су конзуматорни и бихевиорални исходи неограниченог уноса шећера, као и накнадног смањења доступности шећера код адултних мужјака C57BL/6J мишева применом модификоване парадигме „Конзуматорни сукцесивни негативни контраст“ (cSNC).1,2 Две групе животиња имале су неограничен приступ 32% раствору сахарозе 10 дана (у виду тзв. Two- Bottle-Choice протокола); 11. дана једна група добила је раствор са мањом концентрацијом сахарозе (32%→4%), док је друга група добила уобичајени 32% раствор. Контролна група је имала ad libitum приступ води. Дванаестог дана стандардизованим тестовима понашања (Тест отвореног поља, Крстасти лавиринт и Туба тест социјалне конфронтације) испитани су социјална доминација, као и новином-изазвано експлораторно и понашање слично анксиозности. Добијени резултати указују на централни утицај неограниченог уноса шећера с обзиром да је код C57BL/6J мужјака уочен анксиолитички ефекат на понашање који вероватно одражава физиолошку дисрегулацију и склоност тражењу сензација. Потенцијални простор за примену нове модификоване парадигме у испитивању патолошких последица неограниченог уноса шећера даље је размотрен., Većina dostupnih životinjskih modela zavisnosti od šećera ne uključuje komponentu samo-administriranja supstance, a poznato je da se kod ljudi konzumiranje šećera odvija u ad libitum uslovima. Kako bi prevazišli ovaj problem, u ovoj studiji ispitani su konzumatorni i bihevioralni ishodi neograničenog unosa šećera, kao i naknadnog smanjenja dostupnosti šećera kod adultnih mužjaka C57BL/6J miševa primenom modifikovane paradigme „Konzumatorni sukcesivni negativni kontrast“ (cSNC).1,2 Dve grupe životinja imale su neograničen pristup 32% rastvoru saharoze 10 dana (u vidu tzv. Two- Bottle-Choice protokola); 11. dana jedna grupa dobila je rastvor sa manjom koncentracijom saharoze (32%→4%), dok je druga grupa dobila uobičajeni 32% rastvor. Kontrolna grupa je imala ad libitum pristup vodi. Dvanaestog dana standardizovanim testovima ponašanja (Test otvorenog polja, Krstasti lavirint i Tuba test socijalne konfrontacije) ispitani su socijalna dominacija, kao i novinom-izazvano eksploratorno i ponašanje slično anksioznosti. Dobijeni rezultati ukazuju na centralni uticaj neograničenog unosa šećera s obzirom da je kod C57BL/6J mužjaka uočen anksiolitički efekat na ponašanje koji verovatno odražava fiziološku disregulaciju i sklonost traženju senzacija. Potencijalni prostor za primenu nove modifikovane paradigme u ispitivanju patoloških posledica neograničenog unosa šećera dalje je razmotren.",
publisher = "Belgrade: Serbian Biological Society",
journal = "Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia",
title = "Конзуматорне и бихевиоралне последице неограниченог уноса шећера и  накнадног смањења доступности шећера, Konzumatorne i bihevioralne posledice neograničenog unosa šećera i naknadnog smanjenja dostupnosti šećera",
pages = "384",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5617"
}

Dubljević, O., Ković, V., Pavković, Ž., Mitić, M.,& Pešić, V.. (2022). Конзуматорне и бихевиоралне последице неограниченог уноса шећера и  накнадног смањења доступности шећера. in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia
Belgrade: Serbian Biological Society., 384.
https://hdl.handle.net/21.15107/rcub_ibiss_5617

Dubljević O, Ković V, Pavković Ž, Mitić M, Pešić V. Конзуматорне и бихевиоралне последице неограниченог уноса шећера и  накнадног смањења доступности шећера. in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia. 2022;:384.
https://hdl.handle.net/21.15107/rcub_ibiss_5617 .

Dubljević, Olga, Ković, Vanja, Pavković, Željko, Mitić, Miloš, Pešić, Vesna, "Конзуматорне и бихевиоралне последице неограниченог уноса шећера и  накнадног смањења доступности шећера" in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia (2022):384,
https://hdl.handle.net/21.15107/rcub_ibiss_5617 .

TY  - CONF
AU  - Potrebić, Milica
AU  - Pavković, Željko
AU  - Pešić, Vesna
PY  - 2022
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5609
AB  - The influence of parental social experience on the offspring neurodevelopment and its own susceptibility to the sculpting effect of social experience are not well understood. Using rat model we aimed to examine whether and how social experience of adolescent parents impacts psychophysical characteristics of their offspring, during pre-weaning period and later during adolescent growing in defined social conditions. 
Methods: Peripubertal Wistar rats (both sexes) were randomly selected for group housing (GH; n=3 per cage) or single housing (SH; n=1 per cage) at postnatal day (P) 29 and left undisturbed until P55. Thereafter, they were grouped for mating (SH males with SH females, GH males with GH females). Body weight (BW) of pups was monitored at P7, P14, and P21. At P17 motor activity of the offspring was monitored; at P29 the animals were subjected to GH or SH; after 1 week (P36) and 2 weeks (P43) their motor activity was monitored; at P45 they were subjected to sucrose preference test (SPT). 
Results: The male offspring of SH parents had decreased locomotor activity in a novel open arena, at P17. At P36 and P43, adolescent SH offspring showed hypolocomotion in a novel arena and hypohedonic behavior in SPT compared to GH counterparts, regardless of parental experience. BW did not differ between groups. 
Conclusions: Parental social experience influences novelty-exploring behavior of offspring, producing response below expected at P17. With further offspring development, their individual social experience has stronger impact on the appearance of depression-like phenotypes than parental social experience.
PB  - Federation of European Neuroscience Societies
C3  - E-book of Abstracts: FENS Forum 2022; 2022 Jul 9-13; Paris, France
T1  - The influence of parental social experience of offspring novelty-exploring and drepression-like behavior
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5609
ER  - 

@conference{
author = "Potrebić, Milica and Pavković, Željko and Pešić, Vesna",
year = "2022",
abstract = "The influence of parental social experience on the offspring neurodevelopment and its own susceptibility to the sculpting effect of social experience are not well understood. Using rat model we aimed to examine whether and how social experience of adolescent parents impacts psychophysical characteristics of their offspring, during pre-weaning period and later during adolescent growing in defined social conditions. 
Methods: Peripubertal Wistar rats (both sexes) were randomly selected for group housing (GH; n=3 per cage) or single housing (SH; n=1 per cage) at postnatal day (P) 29 and left undisturbed until P55. Thereafter, they were grouped for mating (SH males with SH females, GH males with GH females). Body weight (BW) of pups was monitored at P7, P14, and P21. At P17 motor activity of the offspring was monitored; at P29 the animals were subjected to GH or SH; after 1 week (P36) and 2 weeks (P43) their motor activity was monitored; at P45 they were subjected to sucrose preference test (SPT). 
Results: The male offspring of SH parents had decreased locomotor activity in a novel open arena, at P17. At P36 and P43, adolescent SH offspring showed hypolocomotion in a novel arena and hypohedonic behavior in SPT compared to GH counterparts, regardless of parental experience. BW did not differ between groups. 
Conclusions: Parental social experience influences novelty-exploring behavior of offspring, producing response below expected at P17. With further offspring development, their individual social experience has stronger impact on the appearance of depression-like phenotypes than parental social experience.",
publisher = "Federation of European Neuroscience Societies",
journal = "E-book of Abstracts: FENS Forum 2022; 2022 Jul 9-13; Paris, France",
title = "The influence of parental social experience of offspring novelty-exploring and drepression-like behavior",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5609"
}

Potrebić, M., Pavković, Ž.,& Pešić, V.. (2022). The influence of parental social experience of offspring novelty-exploring and drepression-like behavior. in E-book of Abstracts: FENS Forum 2022; 2022 Jul 9-13; Paris, France
Federation of European Neuroscience Societies..
https://hdl.handle.net/21.15107/rcub_ibiss_5609

Potrebić M, Pavković Ž, Pešić V. The influence of parental social experience of offspring novelty-exploring and drepression-like behavior. in E-book of Abstracts: FENS Forum 2022; 2022 Jul 9-13; Paris, France. 2022;.
https://hdl.handle.net/21.15107/rcub_ibiss_5609 .

Potrebić, Milica, Pavković, Željko, Pešić, Vesna, "The influence of parental social experience of offspring novelty-exploring and drepression-like behavior" in E-book of Abstracts: FENS Forum 2022; 2022 Jul 9-13; Paris, France (2022),
https://hdl.handle.net/21.15107/rcub_ibiss_5609 .

TY  - JOUR
AU  - Potrebić, Milica
AU  - Pavković, Željko
AU  - Lončarević-Vasiljković, Nataša
AU  - Kanazir, Selma
AU  - Pešić, Vesna
PY  - 2021
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4073
AB  - Reduction in direct social contact with peers during early adolescence is thought to be a risk factor for an increase in depressive symptoms, but there is still no clear evidence to suggest early behavioral manifestations and their association with the later outcome of social distancing during this period. To address this question, we used social isolation paradigm in peripubertal rats as the rodent model of adolescence. The litter was an experimental unit. On postnatal day 29, each litter gave group-housed and single-housed males, which were reared and tested one week and two weeks thereafter. Psychomotor/emotional response to novelty in exploration-based tasks, behavioral and neuronal responses to the drug reward (D-amphetamine), motivation/hedonic behavior, physiological and response to physiological stress were examined. Social isolation in peripubertal rats manifested through: hyper-reactivity/agitation and the state anxiety/risk-taking at an early stage; reduced behavioral response to D-amphetamine and altered neural processing of this stimulus, at a later stage; consummatory hypohedonia that deepened over time without changing the motivation to eat; unchanged body weight gain and resting blood corticosterone, cortisol and glucose levels over time; altered blood biochemistry (silenced corticosterone and increased glucose) due to overnight fasting only at an early stage. Our results highlight that the outcome of reduced direct social contact with peers during peripuberty is dynamic, with the cluster of atypical early symptoms that evolve into the syndrome that is delicate for assessment through routinely measurable behavior and biomarkers of stress, but with progressive consummatory hypohedonia and unaffected motivation to eat as stable marks.
PB  - Elsevier Inc.
T2  - Progress in Neuro-Psychopharmacology and Biological Psychiatry
T1  - Altered hedonic, novelty-, stress- and D-amphetamine-induced response to due to social isolation in peripuberty
VL  - 108
DO  - 10.1016/j.pnpbp.2020.110186
SP  - 110186
ER  - 

@article{
author = "Potrebić, Milica and Pavković, Željko and Lončarević-Vasiljković, Nataša and Kanazir, Selma and Pešić, Vesna",
year = "2021",
abstract = "Reduction in direct social contact with peers during early adolescence is thought to be a risk factor for an increase in depressive symptoms, but there is still no clear evidence to suggest early behavioral manifestations and their association with the later outcome of social distancing during this period. To address this question, we used social isolation paradigm in peripubertal rats as the rodent model of adolescence. The litter was an experimental unit. On postnatal day 29, each litter gave group-housed and single-housed males, which were reared and tested one week and two weeks thereafter. Psychomotor/emotional response to novelty in exploration-based tasks, behavioral and neuronal responses to the drug reward (D-amphetamine), motivation/hedonic behavior, physiological and response to physiological stress were examined. Social isolation in peripubertal rats manifested through: hyper-reactivity/agitation and the state anxiety/risk-taking at an early stage; reduced behavioral response to D-amphetamine and altered neural processing of this stimulus, at a later stage; consummatory hypohedonia that deepened over time without changing the motivation to eat; unchanged body weight gain and resting blood corticosterone, cortisol and glucose levels over time; altered blood biochemistry (silenced corticosterone and increased glucose) due to overnight fasting only at an early stage. Our results highlight that the outcome of reduced direct social contact with peers during peripuberty is dynamic, with the cluster of atypical early symptoms that evolve into the syndrome that is delicate for assessment through routinely measurable behavior and biomarkers of stress, but with progressive consummatory hypohedonia and unaffected motivation to eat as stable marks.",
publisher = "Elsevier Inc.",
journal = "Progress in Neuro-Psychopharmacology and Biological Psychiatry",
title = "Altered hedonic, novelty-, stress- and D-amphetamine-induced response to due to social isolation in peripuberty",
volume = "108",
doi = "10.1016/j.pnpbp.2020.110186",
pages = "110186"
}

Potrebić, M., Pavković, Ž., Lončarević-Vasiljković, N., Kanazir, S.,& Pešić, V.. (2021). Altered hedonic, novelty-, stress- and D-amphetamine-induced response to due to social isolation in peripuberty. in Progress in Neuro-Psychopharmacology and Biological Psychiatry
Elsevier Inc.., 108, 110186.
https://doi.org/10.1016/j.pnpbp.2020.110186

Potrebić M, Pavković Ž, Lončarević-Vasiljković N, Kanazir S, Pešić V. Altered hedonic, novelty-, stress- and D-amphetamine-induced response to due to social isolation in peripuberty. in Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2021;108:110186.
doi:10.1016/j.pnpbp.2020.110186 .

Potrebić, Milica, Pavković, Željko, Lončarević-Vasiljković, Nataša, Kanazir, Selma, Pešić, Vesna, "Altered hedonic, novelty-, stress- and D-amphetamine-induced response to due to social isolation in peripuberty" in Progress in Neuro-Psychopharmacology and Biological Psychiatry, 108 (2021):110186,
https://doi.org/10.1016/j.pnpbp.2020.110186 . .

TY  - JOUR
AU  - Petković, Branka
AU  - Kesić, Srđan
AU  - Pešić, Vesna
PY  - 2020
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3642
AB  - Substance-use disorder represents a frequently hidden non-communicable chronic disease. Patients with intravenous drug addiction are at high risk of direct exposure to a variety of viral infections and are considered to be the largest subpopulation infected with the hepatitis C virus. Ribavirin is a synthetic nucleoside analog that has been used as an integral component of hepatitis C therapy. However, ribavirin medication is quite often associated with pronounced psychiatric adverse effects. It is not well understood to what extent ribavirin per se contributes to changes in drug-related neurobehavioral disturbances, especially in the case of psychostimulant drugs such as amphetamine. It is now well-known that repeated amphetamine usage produces psychosis in humans and behavioral sensitization in animals. On the other hand, ribavirin has an affinity for adenosine A1 receptors that antagonistically modulate the activity of dopamine D1 receptors, which play a critical role in the development of behavioral sensitization. This review will focus on the current knowledge of neurochemical/neurobiological changes that exist in the psychostimulant drug-addicted brain itself and the antipsychotic-like efficiency of adenosine agonists. Particular attention will be paid to the potential side effects of ribavirin therapy, and the opportunities and challenges related to its application in already existing psychostimulant-use disorder.
PB  - Bentham Science Publishers Ltd.
T2  - Current Pharmaceutical Design
T1  - Critical View on the Usage of Ribavirin in Already Existing Psychostimulant-Use Disorder
IS  - 4
VL  - 26
DO  - 10.2174/1381612826666200115094642
SP  - 466
EP  - 484
ER  - 

@article{
author = "Petković, Branka and Kesić, Srđan and Pešić, Vesna",
year = "2020",
abstract = "Substance-use disorder represents a frequently hidden non-communicable chronic disease. Patients with intravenous drug addiction are at high risk of direct exposure to a variety of viral infections and are considered to be the largest subpopulation infected with the hepatitis C virus. Ribavirin is a synthetic nucleoside analog that has been used as an integral component of hepatitis C therapy. However, ribavirin medication is quite often associated with pronounced psychiatric adverse effects. It is not well understood to what extent ribavirin per se contributes to changes in drug-related neurobehavioral disturbances, especially in the case of psychostimulant drugs such as amphetamine. It is now well-known that repeated amphetamine usage produces psychosis in humans and behavioral sensitization in animals. On the other hand, ribavirin has an affinity for adenosine A1 receptors that antagonistically modulate the activity of dopamine D1 receptors, which play a critical role in the development of behavioral sensitization. This review will focus on the current knowledge of neurochemical/neurobiological changes that exist in the psychostimulant drug-addicted brain itself and the antipsychotic-like efficiency of adenosine agonists. Particular attention will be paid to the potential side effects of ribavirin therapy, and the opportunities and challenges related to its application in already existing psychostimulant-use disorder.",
publisher = "Bentham Science Publishers Ltd.",
journal = "Current Pharmaceutical Design",
title = "Critical View on the Usage of Ribavirin in Already Existing Psychostimulant-Use Disorder",
number = "4",
volume = "26",
doi = "10.2174/1381612826666200115094642",
pages = "466-484"
}

Petković, B., Kesić, S.,& Pešić, V.. (2020). Critical View on the Usage of Ribavirin in Already Existing Psychostimulant-Use Disorder. in Current Pharmaceutical Design
Bentham Science Publishers Ltd.., 26(4), 466-484.
https://doi.org/10.2174/1381612826666200115094642

Petković B, Kesić S, Pešić V. Critical View on the Usage of Ribavirin in Already Existing Psychostimulant-Use Disorder. in Current Pharmaceutical Design. 2020;26(4):466-484.
doi:10.2174/1381612826666200115094642 .

Petković, Branka, Kesić, Srđan, Pešić, Vesna, "Critical View on the Usage of Ribavirin in Already Existing Psychostimulant-Use Disorder" in Current Pharmaceutical Design, 26, no. 4 (2020):466-484,
https://doi.org/10.2174/1381612826666200115094642 . .

TY  - JOUR
AU  - Petković, Branka
AU  - Kesić, Srđan
AU  - Ristić, Slavica
AU  - Pavković, Željko
AU  - Podgorac, Jelena
AU  - Stojadinović, Gordana
AU  - Pešić, Vesna
PY  - 2020
UR  - https://www.eurekaselect.com/180519/article
UR  - http://www.ncbi.nlm.nih.gov/pubmed/32213154
UR  - https://radar.ibiss.bg.ac.rs/123456789/3879
AB  - BACKGROUND Psychotic states related to psychostimulant misuse in patients with hepatitis C virus infection may complicate acceptance and reaction to antiviral treatment. This observation equally applies to widely used ribavirin therapy. OBJECTIVE We examined psychomotor and body weight gain response to low ribavirin doses after cessation of intermittent amphetamine treatment in adult rats to assess its role in neurobehavioral outcome during psychostimulant withdrawal. METHOD The model of amphetamine-induced (1.5 mg/kg/day, i.p., 7 consecutive days) motor sensitization and affected body weight gain was established in adult male Wistar rats. Then, additional cohort of amphetamine-sensitized rats was subjected to saline (0.9% NaCl; 1 mL/kg/day; i.p.) or ribavirin (10, 20 and 30 mg/kg/day, i.p.) treatment for 7 consecutive days. Animals' motor activity in a novel environment was monitored after the 1st and the 7th saline/ribavirin injection. Body weight gain was calculated as appropriate. Determination and quantification of ribavirin in the brain tissue were performed too. RESULTS The 1st application of ribavirin to amphetamine-sensitized rats affected/decreased their novelty-induced motor activity only at a dose of 30 mg/kg. After the 7th application, ribavirin 30 mg/kg/day still decreased while 10 and 20 mg/kg/day increased novelty-induced motor activity. These behavioral effects coincided with the time required to reach maximum ribavirin concentration in the brain. Body weight gain during withdrawal was not influenced by any of the doses tested. CONCLUSION Ribavirin displays central effects that in repeated treatment, depending on the applied dose, could significantly influence psychomotor response but not body weight gain during psychostimulant/amphetamine withdrawal.
PB  - Bentham Science Publishers Ltd.
T2  - Current Pharmaceutical Design
T1  - A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats
IS  - 31
VL  - 26
DO  - 10.2174/1381612826666200326125821
SP  - 3884
EP  - 3894
ER  - 

@article{
author = "Petković, Branka and Kesić, Srđan and Ristić, Slavica and Pavković, Željko and Podgorac, Jelena and Stojadinović, Gordana and Pešić, Vesna",
year = "2020",
abstract = "BACKGROUND Psychotic states related to psychostimulant misuse in patients with hepatitis C virus infection may complicate acceptance and reaction to antiviral treatment. This observation equally applies to widely used ribavirin therapy. OBJECTIVE We examined psychomotor and body weight gain response to low ribavirin doses after cessation of intermittent amphetamine treatment in adult rats to assess its role in neurobehavioral outcome during psychostimulant withdrawal. METHOD The model of amphetamine-induced (1.5 mg/kg/day, i.p., 7 consecutive days) motor sensitization and affected body weight gain was established in adult male Wistar rats. Then, additional cohort of amphetamine-sensitized rats was subjected to saline (0.9% NaCl; 1 mL/kg/day; i.p.) or ribavirin (10, 20 and 30 mg/kg/day, i.p.) treatment for 7 consecutive days. Animals' motor activity in a novel environment was monitored after the 1st and the 7th saline/ribavirin injection. Body weight gain was calculated as appropriate. Determination and quantification of ribavirin in the brain tissue were performed too. RESULTS The 1st application of ribavirin to amphetamine-sensitized rats affected/decreased their novelty-induced motor activity only at a dose of 30 mg/kg. After the 7th application, ribavirin 30 mg/kg/day still decreased while 10 and 20 mg/kg/day increased novelty-induced motor activity. These behavioral effects coincided with the time required to reach maximum ribavirin concentration in the brain. Body weight gain during withdrawal was not influenced by any of the doses tested. CONCLUSION Ribavirin displays central effects that in repeated treatment, depending on the applied dose, could significantly influence psychomotor response but not body weight gain during psychostimulant/amphetamine withdrawal.",
publisher = "Bentham Science Publishers Ltd.",
journal = "Current Pharmaceutical Design",
title = "A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats",
number = "31",
volume = "26",
doi = "10.2174/1381612826666200326125821",
pages = "3884-3894"
}

Petković, B., Kesić, S., Ristić, S., Pavković, Ž., Podgorac, J., Stojadinović, G.,& Pešić, V.. (2020). A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats. in Current Pharmaceutical Design
Bentham Science Publishers Ltd.., 26(31), 3884-3894.
https://doi.org/10.2174/1381612826666200326125821

Petković B, Kesić S, Ristić S, Pavković Ž, Podgorac J, Stojadinović G, Pešić V. A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats. in Current Pharmaceutical Design. 2020;26(31):3884-3894.
doi:10.2174/1381612826666200326125821 .

Petković, Branka, Kesić, Srđan, Ristić, Slavica, Pavković, Željko, Podgorac, Jelena, Stojadinović, Gordana, Pešić, Vesna, "A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats" in Current Pharmaceutical Design, 26, no. 31 (2020):3884-3894,
https://doi.org/10.2174/1381612826666200326125821 . .

TY  - JOUR
AU  - Petković, Branka
AU  - Kesić, Srđan
AU  - Ristić, Slavica
AU  - Pavković, Željko
AU  - Podgorac, Jelena
AU  - Stojadinović, Gordana
AU  - Pešić, Vesna
PY  - 2020
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3765
AB  - Background: Psychotic states related to psychostimulant misuse in patients with hepatitis C virus infection may complicate acceptance and reaction to antiviral treatment. This observation equally applies to widely used ribavirin therapy.
Objective: We examined psychomotor and body weight gain response to low ribavirin doses after cessation of intermittent amphetamine treatment in adult rats to assess its role in neurobehavioral outcome during psychostimulant withdrawal.
Method: The model of amphetamine-induced (1.5 mg/kg/day, i.p., 7 consecutive days) motor sensitization and affected body weight gain was established in adult male Wistar rats. Then, additional cohort of amphetamine-sensitized rats was subjected to saline (0.9% NaCl; 1 mL/kg/day; i.p.) or ribavirin (10, 20 and 30 mg/kg/day, i.p.) treatment for 7 consecutive days. Animals’ motor activity in a novel environment was monitored after the 1st and the 7th saline/ribavirin injection. Body weight gain was calculated as appropriate. Determination and quantification of ribavirin in the brain tissue were performed too.
Results: The 1st application of ribavirin to amphetamine-sensitized rats affected/decreased their novelty-induced motor activity only at a dose of 30 mg/kg. After the 7th application, ribavirin 30 mg/kg/day still decreased while 10 and 20 mg/kg/day increased novelty-induced motor activity. These behavioral effects coincided with the time required to reach maximum ribavirin concentration in the brain. Body weight gain during withdrawal was not influenced by any of the doses tested.
Conclusion: Ribavirin displays central effects that in repeated treatment, depending on the applied dose, could significantly influence psychomotor response but not body weight gain during psychostimulant/amphetamine withdrawal.
PB  - Bentham Science Publishers Ltd.
T2  - Current Pharmaceutical Design
T1  - A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats
DO  - 10.2174/1381612826666200326125821
ER  - 

@article{
author = "Petković, Branka and Kesić, Srđan and Ristić, Slavica and Pavković, Željko and Podgorac, Jelena and Stojadinović, Gordana and Pešić, Vesna",
year = "2020",
abstract = "Background: Psychotic states related to psychostimulant misuse in patients with hepatitis C virus infection may complicate acceptance and reaction to antiviral treatment. This observation equally applies to widely used ribavirin therapy.
Objective: We examined psychomotor and body weight gain response to low ribavirin doses after cessation of intermittent amphetamine treatment in adult rats to assess its role in neurobehavioral outcome during psychostimulant withdrawal.
Method: The model of amphetamine-induced (1.5 mg/kg/day, i.p., 7 consecutive days) motor sensitization and affected body weight gain was established in adult male Wistar rats. Then, additional cohort of amphetamine-sensitized rats was subjected to saline (0.9% NaCl; 1 mL/kg/day; i.p.) or ribavirin (10, 20 and 30 mg/kg/day, i.p.) treatment for 7 consecutive days. Animals’ motor activity in a novel environment was monitored after the 1st and the 7th saline/ribavirin injection. Body weight gain was calculated as appropriate. Determination and quantification of ribavirin in the brain tissue were performed too.
Results: The 1st application of ribavirin to amphetamine-sensitized rats affected/decreased their novelty-induced motor activity only at a dose of 30 mg/kg. After the 7th application, ribavirin 30 mg/kg/day still decreased while 10 and 20 mg/kg/day increased novelty-induced motor activity. These behavioral effects coincided with the time required to reach maximum ribavirin concentration in the brain. Body weight gain during withdrawal was not influenced by any of the doses tested.
Conclusion: Ribavirin displays central effects that in repeated treatment, depending on the applied dose, could significantly influence psychomotor response but not body weight gain during psychostimulant/amphetamine withdrawal.",
publisher = "Bentham Science Publishers Ltd.",
journal = "Current Pharmaceutical Design",
title = "A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats",
doi = "10.2174/1381612826666200326125821"
}

Petković, B., Kesić, S., Ristić, S., Pavković, Ž., Podgorac, J., Stojadinović, G.,& Pešić, V.. (2020). A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats. in Current Pharmaceutical Design
Bentham Science Publishers Ltd...
https://doi.org/10.2174/1381612826666200326125821

Petković B, Kesić S, Ristić S, Pavković Ž, Podgorac J, Stojadinović G, Pešić V. A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats. in Current Pharmaceutical Design. 2020;.
doi:10.2174/1381612826666200326125821 .

Petković, Branka, Kesić, Srđan, Ristić, Slavica, Pavković, Željko, Podgorac, Jelena, Stojadinović, Gordana, Pešić, Vesna, "A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats" in Current Pharmaceutical Design (2020),
https://doi.org/10.2174/1381612826666200326125821 . .

TY  - JOUR
AU  - Petković, Branka
AU  - Kesić, Srđan
AU  - Pešić, Vesna
PY  - 2020
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3642
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3665
AB  - Substance-use disorder represents a frequently hidden non-communicable chronic disease. Patients with intravenous drug addiction are at high risk of direct exposure to a variety of viral infections and are considered to be the largest subpopulation infected with the hepatitis C virus. Ribavirin is a synthetic nucleoside analog that has been used as an integral component of hepatitis C therapy. However, ribavirin medication is quite often associated with pronounced psychiatric adverse effects. It is not well understood to what extent ribavirin per se contributes to changes in drug-related neurobehavioral disturbances, especially in the case of psychostimulant drugs such as amphetamine. It is now well-known that repeated amphetamine usage produces psychosis in humans and behavioral sensitization in animals. On the other hand, ribavirin has an affinity for adenosine A1 receptors that antagonistically modulate the activity of dopamine D1 receptors, which play a critical role in the development of behavioral sensitization. This review will focus on the current knowledge of neurochemical/neurobiological changes that exist in the psychostimulant drug-addicted brain itself and the antipsychotic-like efficiency of adenosine agonists. Particular attention will be paid to the potential side effects of ribavirin therapy, and the opportunities and challenges related to its application in already existing psychostimulant-use disorder.
PB  - Bentham Science Publishers Ltd.
T2  - Current Pharmaceutical Design
T1  - Critical View on the Usage of Ribavirin in Already Existing Psychostimulant-Use Disorder
IS  - 4
VL  - 26
DO  - 10.2174/1381612826666200115094642
SP  - 466
EP  - 484
ER  - 

@article{
author = "Petković, Branka and Kesić, Srđan and Pešić, Vesna",
year = "2020",
abstract = "Substance-use disorder represents a frequently hidden non-communicable chronic disease. Patients with intravenous drug addiction are at high risk of direct exposure to a variety of viral infections and are considered to be the largest subpopulation infected with the hepatitis C virus. Ribavirin is a synthetic nucleoside analog that has been used as an integral component of hepatitis C therapy. However, ribavirin medication is quite often associated with pronounced psychiatric adverse effects. It is not well understood to what extent ribavirin per se contributes to changes in drug-related neurobehavioral disturbances, especially in the case of psychostimulant drugs such as amphetamine. It is now well-known that repeated amphetamine usage produces psychosis in humans and behavioral sensitization in animals. On the other hand, ribavirin has an affinity for adenosine A1 receptors that antagonistically modulate the activity of dopamine D1 receptors, which play a critical role in the development of behavioral sensitization. This review will focus on the current knowledge of neurochemical/neurobiological changes that exist in the psychostimulant drug-addicted brain itself and the antipsychotic-like efficiency of adenosine agonists. Particular attention will be paid to the potential side effects of ribavirin therapy, and the opportunities and challenges related to its application in already existing psychostimulant-use disorder.",
publisher = "Bentham Science Publishers Ltd.",
journal = "Current Pharmaceutical Design",
title = "Critical View on the Usage of Ribavirin in Already Existing Psychostimulant-Use Disorder",
number = "4",
volume = "26",
doi = "10.2174/1381612826666200115094642",
pages = "466-484"
}

Petković, B., Kesić, S.,& Pešić, V.. (2020). Critical View on the Usage of Ribavirin in Already Existing Psychostimulant-Use Disorder. in Current Pharmaceutical Design
Bentham Science Publishers Ltd.., 26(4), 466-484.
https://doi.org/10.2174/1381612826666200115094642

Petković B, Kesić S, Pešić V. Critical View on the Usage of Ribavirin in Already Existing Psychostimulant-Use Disorder. in Current Pharmaceutical Design. 2020;26(4):466-484.
doi:10.2174/1381612826666200115094642 .

Petković, Branka, Kesić, Srđan, Pešić, Vesna, "Critical View on the Usage of Ribavirin in Already Existing Psychostimulant-Use Disorder" in Current Pharmaceutical Design, 26, no. 4 (2020):466-484,
https://doi.org/10.2174/1381612826666200115094642 . .