@conference{
author = "Mirkov, Ivana and Popov Aleksandrov, Aleksandra and Tucović, Dina and Kulaš, Jelena and Popović, Dušanka and Malešević, Anastasija and Kataranovski, Milena",
year = "2022",
abstract = "In addition to physical and chemical insults originating from nature (heavy metals, radiation, electromagnetic field), human beings are exposed to various agents as a result of progress in industry and technology (noise, pesticides, pharmaceuticals, personal care products, food additives, etc.) whose number continuously increases. Some of these agents may have adverse effects on the environment and human health and therefore every new product must be examined for its toxic potential and health risk. The immune system is an important homeostatic system that is included in response to various pathogens, but in other processes as well including wound healing and elimination of damaged cells and tumors. Due to its involvement in various physiological processes, alternation in immune system activity, as a consequence of exposure to xenobiotics, may cause an increase in the incidence of infections, tumors, allergies, and autoimmune diseases. Various tests that exist for the evaluation of immunotoxicity are grouped in two separate sets, tier one (experiments directed to measure the effect of xenobiotics on general immune parameters i.e. basic morphological and functional tests) and tier two(experiments aimed to more specifically define the cellular and biochemical mechanisms of toxicity). Evaluation of potential adverse effects of xenobiotics on the immune system is now incorporated into standard hazard identification and has improved human health risk assessment., Pored fizičkih i hemijskih agenasa poreklom iz prirode (teški metali, zračenje, elektromagnetno polje), ljudska bića su izložena raznim agensima kao rezultat napretka industrije i tehnologije (buka, pesticidi, farmaceutski proizvodi, proizvodi za ličnu negu, aditivi u hrani, itd.) čiji se broj kontinuirano povećava. Neki od ovih agenasa mogu imati štetne efekte na životnu sredinu i zdravlje ljudi i stoga za svaki novi proizvod mora biti ispitan njegov toksični potencijal i rizik po zdravlje. Imunski sistem je važan homeostatski sistem koji je uključen u odgovor na različite patogene, ali i u druge procese kao što su zarastanje rana, eliminaciju oštećenih ćelija i tumora. Zbog uključenosti u različite fiziološke procese, promenjena aktivnost imunskog sistema, kao posledica izloženosti ksenobioticima, može dovesti do povećanja učestalosti infekcija, tumora, alergija i autoimunskih bolesti. Postoje različiti testovi za procenu imunotoksičnosti koji su grupisani u dva odvojena seta, prvi nivo (eksperimenti usmereni na merenje uticaja ksenobiotika na opšte imunološke parametre, tj. osnovni morfološki i funkcionalni testovi) i nivo dva (eksperimenti koji imaju za cilj da preciznije definišu ćelijske i biohemijske mehanizme toksičnosti). Procena potencijalnih štetnih efekata ksenobiotika na imunski sistem je sada uključena u standardnu identifikaciju opasnosti i poboljšala je procenu rizika koju ksenobiotici mogu imati po zdravlje ljudi.",
publisher = "Belgrade: Serbian Society of Corrosion and Materials Protection",
journal = "Proceedings: Meeting point of the science and practice in the fields of corrosion, materials and environmental protection: XXIII YuCorr International Conference; 2022 May 16-19; Divčibare, Serbia",
title = "Immune System as a Target of Xenobiotics Toxicity, Imunski sistem kao meta toksičnog delovanja ksenobiotika",
pages = "7-13",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5142"
}