TY  - JOUR
AU  - Petrou, Anthi
AU  - Kartsev, Victor
AU  - Geronikaki, Athina
AU  - Glamočlija, Jasmina
AU  - Ćirić, Ana
AU  - Soković, Marina
PY  - 2023
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5796
AB  - Nine new functionally substituted derivatives of 2-aminothiazole 
were evaluated for antimicrobial activity using microdilution 
method against the panel of eight bacterial and eight fungal strains. 
Evaluation of antibacterial activity revealed that compounds are 
potent antibacterial agents, more active than ampicillin and strep tomycin except of some compounds against B. cereus and En. 
cloacae. The best compound appeared to be compound 8. The 
most sensitive bacteria appeared to be En. cloacae, while L. mono cytogenes was the most resistant. Compounds also exhibited good 
antifungal activity much better than two reference drugs, ketoco nazole and bifonazole. Compound 1 exhibited the best antifungal 
activity. The most sensitive fungus was T. viride, while A. fumigatus 
was the most resistant. Bacteria as well as fungi in general showed 
different sensitivity towards compounds tested. Molecular docking 
studies revealed that MurB inhibition is probably involved in the 
mechanism of antibacterial activity, while CYP51 of C. albicans is 
responsible for the mechanism of antifungal activity. Finally, it 
should be mentioned that all compounds displayed very good 
druglikeness scores
PB  - Taylor & Francis Group
T2  - SAR and QSAR in Environmental Research
T1  - Functionally substituted 2-aminothiazoles as antimicrobial agents: in vitro and in silico evaluation
IS  - 5
VL  - 34
DO  - 10.1080/1062936X.2023.2214869
SP  - 359
EP  - 414
ER  - 

@article{
author = "Petrou, Anthi and Kartsev, Victor and Geronikaki, Athina and Glamočlija, Jasmina and Ćirić, Ana and Soković, Marina",
year = "2023",
abstract = "Nine new functionally substituted derivatives of 2-aminothiazole 
were evaluated for antimicrobial activity using microdilution 
method against the panel of eight bacterial and eight fungal strains. 
Evaluation of antibacterial activity revealed that compounds are 
potent antibacterial agents, more active than ampicillin and strep tomycin except of some compounds against B. cereus and En. 
cloacae. The best compound appeared to be compound 8. The 
most sensitive bacteria appeared to be En. cloacae, while L. mono cytogenes was the most resistant. Compounds also exhibited good 
antifungal activity much better than two reference drugs, ketoco nazole and bifonazole. Compound 1 exhibited the best antifungal 
activity. The most sensitive fungus was T. viride, while A. fumigatus 
was the most resistant. Bacteria as well as fungi in general showed 
different sensitivity towards compounds tested. Molecular docking 
studies revealed that MurB inhibition is probably involved in the 
mechanism of antibacterial activity, while CYP51 of C. albicans is 
responsible for the mechanism of antifungal activity. Finally, it 
should be mentioned that all compounds displayed very good 
druglikeness scores",
publisher = "Taylor & Francis Group",
journal = "SAR and QSAR in Environmental Research",
title = "Functionally substituted 2-aminothiazoles as antimicrobial agents: in vitro and in silico evaluation",
number = "5",
volume = "34",
doi = "10.1080/1062936X.2023.2214869",
pages = "359-414"
}

Petrou, A., Kartsev, V., Geronikaki, A., Glamočlija, J., Ćirić, A.,& Soković, M.. (2023). Functionally substituted 2-aminothiazoles as antimicrobial agents: in vitro and in silico evaluation. in SAR and QSAR in Environmental Research
Taylor & Francis Group., 34(5), 359-414.
https://doi.org/10.1080/1062936X.2023.2214869

Petrou A, Kartsev V, Geronikaki A, Glamočlija J, Ćirić A, Soković M. Functionally substituted 2-aminothiazoles as antimicrobial agents: in vitro and in silico evaluation. in SAR and QSAR in Environmental Research. 2023;34(5):359-414.
doi:10.1080/1062936X.2023.2214869 .

Petrou, Anthi, Kartsev, Victor, Geronikaki, Athina, Glamočlija, Jasmina, Ćirić, Ana, Soković, Marina, "Functionally substituted 2-aminothiazoles as antimicrobial agents: in vitro and in silico evaluation" in SAR and QSAR in Environmental Research, 34, no. 5 (2023):359-414,
https://doi.org/10.1080/1062936X.2023.2214869 . .

TY  - JOUR
AU  - Barbakadze, Vakhtang
AU  - Merlani, Maia
AU  - Gogilashvili, Lali
AU  - Amiranashvili, Lela
AU  - Petrou, Anthi
AU  - Geronikaki, Athina
AU  - Ćirić, Ana
AU  - Glamočlija, Jasmina
AU  - Soković, Marina
PY  - 2023
UR  - https://www.mdpi.com/2079-6382/12/2/285
UR  - http://www.ncbi.nlm.nih.gov/pubmed/36830198
UR  - http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC9952037
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5491
AB  - This study reports the antimicrobial activities of the biopolymers poly[3-(3,4-dihydoxyphenyl)glyceric acid] (PDHPGA) and poly[2-methoxycarbonyl-3-(3,4-dihydroxyphenyl)oxirane] (PMDHPO), extracted from the six plants of Boraginaceae family: Symphytum asperum (SA), S. caucasicum (SC), S. gr and iflorum (SG), Anchusa italica (AI), Cynoglosum officinale (CO), and Borago officinalis (BO) collected in various parts of Georgia. The study revealed that the antibacterial activities were moderate, and biopolymers from only three plants showed activities against all tested bacteria. Biopolymers from CO stems as well as SC and AI did not show any activity except low activity against a resistant P. aeruginosa strain, which was the most resistant among all three resistant strains. On the other hand, the antifungal activity was better compared to the antibacterial activity. Biopolymers from BO stems exhibited the best activities with MIC/MFC at 0.37-1.00 mg/mL and 0.75-1.5 mg/L, respectively, followed by those from SG stems. Biopolymers from SC and AI roots showed antifungal activities against all six fungi, in contrast to the antibacterial activity, while biopolymers from CO stems and SA roots had activities against four fungi and one fungus, respectively. The sugar-based catechol-containing biopolymers from BO stems demonstrated the best activities among all tested biopolymers against T. viride, P. funiculosum, P. cyclpoium var verucosum, and C. albicans (MIC 0.37 mg/mL). In addition, biopolymers from SG stems were half as active against A. fumigatus and T. viride as ketoconazole. Biopolymers from all plant materials except for CO stems showed higher potency than ketoconazole against T. viride. For the first time, it was shown that all plant materials exhibited better activity against C. albicans, one of the most dreadful fungal species.
PB  - Basel: MDPI
T2  - Antibiotics (Basel, Switzerland)
T1  - Antimicrobial Activity of Catechol-Containing Biopolymer Poly[3-(3,4-dihydroxyphenyl)glyceric Acid] from Different Medicinal Plants of Boraginaceae Family
IS  - 2
VL  - 12
DO  - 10.3390/antibiotics12020285
SP  - 285
ER  - 

@article{
author = "Barbakadze, Vakhtang and Merlani, Maia and Gogilashvili, Lali and Amiranashvili, Lela and Petrou, Anthi and Geronikaki, Athina and Ćirić, Ana and Glamočlija, Jasmina and Soković, Marina",
year = "2023",
abstract = "This study reports the antimicrobial activities of the biopolymers poly[3-(3,4-dihydoxyphenyl)glyceric acid] (PDHPGA) and poly[2-methoxycarbonyl-3-(3,4-dihydroxyphenyl)oxirane] (PMDHPO), extracted from the six plants of Boraginaceae family: Symphytum asperum (SA), S. caucasicum (SC), S. gr and iflorum (SG), Anchusa italica (AI), Cynoglosum officinale (CO), and Borago officinalis (BO) collected in various parts of Georgia. The study revealed that the antibacterial activities were moderate, and biopolymers from only three plants showed activities against all tested bacteria. Biopolymers from CO stems as well as SC and AI did not show any activity except low activity against a resistant P. aeruginosa strain, which was the most resistant among all three resistant strains. On the other hand, the antifungal activity was better compared to the antibacterial activity. Biopolymers from BO stems exhibited the best activities with MIC/MFC at 0.37-1.00 mg/mL and 0.75-1.5 mg/L, respectively, followed by those from SG stems. Biopolymers from SC and AI roots showed antifungal activities against all six fungi, in contrast to the antibacterial activity, while biopolymers from CO stems and SA roots had activities against four fungi and one fungus, respectively. The sugar-based catechol-containing biopolymers from BO stems demonstrated the best activities among all tested biopolymers against T. viride, P. funiculosum, P. cyclpoium var verucosum, and C. albicans (MIC 0.37 mg/mL). In addition, biopolymers from SG stems were half as active against A. fumigatus and T. viride as ketoconazole. Biopolymers from all plant materials except for CO stems showed higher potency than ketoconazole against T. viride. For the first time, it was shown that all plant materials exhibited better activity against C. albicans, one of the most dreadful fungal species.",
publisher = "Basel: MDPI",
journal = "Antibiotics (Basel, Switzerland)",
title = "Antimicrobial Activity of Catechol-Containing Biopolymer Poly[3-(3,4-dihydroxyphenyl)glyceric Acid] from Different Medicinal Plants of Boraginaceae Family",
number = "2",
volume = "12",
doi = "10.3390/antibiotics12020285",
pages = "285"
}

Barbakadze, V., Merlani, M., Gogilashvili, L., Amiranashvili, L., Petrou, A., Geronikaki, A., Ćirić, A., Glamočlija, J.,& Soković, M.. (2023). Antimicrobial Activity of Catechol-Containing Biopolymer Poly[3-(3,4-dihydroxyphenyl)glyceric Acid] from Different Medicinal Plants of Boraginaceae Family. in Antibiotics (Basel, Switzerland)
Basel: MDPI., 12(2), 285.
https://doi.org/10.3390/antibiotics12020285

Barbakadze V, Merlani M, Gogilashvili L, Amiranashvili L, Petrou A, Geronikaki A, Ćirić A, Glamočlija J, Soković M. Antimicrobial Activity of Catechol-Containing Biopolymer Poly[3-(3,4-dihydroxyphenyl)glyceric Acid] from Different Medicinal Plants of Boraginaceae Family. in Antibiotics (Basel, Switzerland). 2023;12(2):285.
doi:10.3390/antibiotics12020285 .

Barbakadze, Vakhtang, Merlani, Maia, Gogilashvili, Lali, Amiranashvili, Lela, Petrou, Anthi, Geronikaki, Athina, Ćirić, Ana, Glamočlija, Jasmina, Soković, Marina, "Antimicrobial Activity of Catechol-Containing Biopolymer Poly[3-(3,4-dihydroxyphenyl)glyceric Acid] from Different Medicinal Plants of Boraginaceae Family" in Antibiotics (Basel, Switzerland), 12, no. 2 (2023):285,
https://doi.org/10.3390/antibiotics12020285 . .

TY  - JOUR
AU  - Kartsev, Victor
AU  - Geronikaki, Athina
AU  - Lichitsky, Boris
AU  - Komogortsev, Andrey
AU  - Petrou, Anthi
AU  - Ivanov, Marija
AU  - Glamočlija, Jasmina
AU  - Soković, Marina
PY  - 2022
UR  - https://onlinelibrary.wiley.com/doi/10.1002/jhet.4491
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/4962
AB  - Herein we report the design and synthesis of thiazolo[4,5-b]pyridin-5-ones and evaluation of their antimicrobial activity. The design was based on a molecular hybridization approach. Evaluation of their antibacterial activity revealed that these compounds generally showed moderate antibacterial activity. The best activity was achieved for compound 4p with MIC/MBC in the range of 0.12-0.47 and 0.23-0.94 mg mL(-1) respectively. Three compounds (4g, 4n, and 4p) were tested against three resistant strains, namely MRSA, p.aeruginosa, and E.coli, showing higher inhibition potential than the reference drug ampicillin. These three compounds also were tested for their ability to inhibit biofilm formation, with two of them showing better activity than streptomycin in a concentration of MIC (4p) and ampicillin in both concentrations (MIC and 0.5 MIC). As far as antifungal activity is concerned, the best activity was observed for compound 4i with MIC at 0.12-0.47 mg mL(-1) and MFC at 0.23-0.94 mg m(-1). According to docking studies, the predicted inhibition of E.coli MurB enzyme is probably a putative mechanism of the antibacterial activity of these compounds, while inhibition of 14a-lanosterol demethylase is probably the mechanism of their antifungal activity.
T2  - Journal of Heterocyclic Chemistry
T1  - Synthesis, biological evaluation and molecular docking studies of thiazolo[4,5‐ b ]pyridin‐5‐ones as antimicrobial agents
IS  - 9
VL  - 59
DO  - 10.1002/jhet.4491
SP  - 1573
EP  - 1590
ER  - 

@article{
author = "Kartsev, Victor and Geronikaki, Athina and Lichitsky, Boris and Komogortsev, Andrey and Petrou, Anthi and Ivanov, Marija and Glamočlija, Jasmina and Soković, Marina",
year = "2022",
abstract = "Herein we report the design and synthesis of thiazolo[4,5-b]pyridin-5-ones and evaluation of their antimicrobial activity. The design was based on a molecular hybridization approach. Evaluation of their antibacterial activity revealed that these compounds generally showed moderate antibacterial activity. The best activity was achieved for compound 4p with MIC/MBC in the range of 0.12-0.47 and 0.23-0.94 mg mL(-1) respectively. Three compounds (4g, 4n, and 4p) were tested against three resistant strains, namely MRSA, p.aeruginosa, and E.coli, showing higher inhibition potential than the reference drug ampicillin. These three compounds also were tested for their ability to inhibit biofilm formation, with two of them showing better activity than streptomycin in a concentration of MIC (4p) and ampicillin in both concentrations (MIC and 0.5 MIC). As far as antifungal activity is concerned, the best activity was observed for compound 4i with MIC at 0.12-0.47 mg mL(-1) and MFC at 0.23-0.94 mg m(-1). According to docking studies, the predicted inhibition of E.coli MurB enzyme is probably a putative mechanism of the antibacterial activity of these compounds, while inhibition of 14a-lanosterol demethylase is probably the mechanism of their antifungal activity.",
journal = "Journal of Heterocyclic Chemistry",
title = "Synthesis, biological evaluation and molecular docking studies of thiazolo[4,5‐ b ]pyridin‐5‐ones as antimicrobial agents",
number = "9",
volume = "59",
doi = "10.1002/jhet.4491",
pages = "1573-1590"
}

Kartsev, V., Geronikaki, A., Lichitsky, B., Komogortsev, A., Petrou, A., Ivanov, M., Glamočlija, J.,& Soković, M.. (2022). Synthesis, biological evaluation and molecular docking studies of thiazolo[4,5‐ b ]pyridin‐5‐ones as antimicrobial agents. in Journal of Heterocyclic Chemistry, 59(9), 1573-1590.
https://doi.org/10.1002/jhet.4491

Kartsev V, Geronikaki A, Lichitsky B, Komogortsev A, Petrou A, Ivanov M, Glamočlija J, Soković M. Synthesis, biological evaluation and molecular docking studies of thiazolo[4,5‐ b ]pyridin‐5‐ones as antimicrobial agents. in Journal of Heterocyclic Chemistry. 2022;59(9):1573-1590.
doi:10.1002/jhet.4491 .

Kartsev, Victor, Geronikaki, Athina, Lichitsky, Boris, Komogortsev, Andrey, Petrou, Anthi, Ivanov, Marija, Glamočlija, Jasmina, Soković, Marina, "Synthesis, biological evaluation and molecular docking studies of thiazolo[4,5‐ b ]pyridin‐5‐ones as antimicrobial agents" in Journal of Heterocyclic Chemistry, 59, no. 9 (2022):1573-1590,
https://doi.org/10.1002/jhet.4491 . .

TY  - JOUR
AU  - Horishny, Volodymyr
AU  - Geronikaki, Athina
AU  - Kartsev, Victor
AU  - Matiychuk, Vasyl
AU  - Petrou, Anthi
AU  - Pogodin, Pavel
AU  - Poroikov, Vladimir
AU  - Papadopoulou, Theodora A
AU  - Vizirianakis, Ioannis S
AU  - Kostić, Marina
AU  - Ivanov, Marija
AU  - Soković, Marina
PY  - 2022
UR  - http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC8839324
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/4884
AB  - BACKGROUND Infectious diseases represent a significant global strain on public health security and impact on socio-economic stability all over the world. The increasing resistance to the current antimicrobial treatment has resulted in the crucial need for the discovery and development of novel entities for the infectious treatment with different modes of action that could target both sensitive and resistant strains. METHODS Compounds were synthesized using the classical organic chemistry methods. Prediction of biological activity spectra was carried out using PASS and PASS-based web applications. Pharmacophore modeling in LigandScout software was used for quantitative modeling of the antibacterial activity. Antimicrobial activity was evaluated using the microdilution method. AutoDock 4.2® software was used to elucidate probable bacterial and fungal molecular targets of the studied compounds. RESULTS All compounds exhibited better antibacterial potency than ampicillin against all bacteria tested. Three compounds were tested against resistant strains MRSA, P. aeruginosa and E. coli and were found to be more potent than MRSA than reference drugs. All compounds demonstrated a higher degree of antifungal activity than the reference drugs bifonazole (6-17-fold) and ketoconazole (13-52-fold). Three of the most active compounds could be considered for further development of the new, more potent antimicrobial agents. CONCLUSION Compounds 5b (Z)-3-(3-hydroxyphenyl)-5-((1-methyl-1H-indol-3-yl)methylene)-2-thioxothiazolidin-4-one and 5g (Z)-3-[5-(1H-Indol-3-ylmethylene)-4-oxo-2-thioxo-thiazolidin-3-yl]-benzoic acid as well as 5h (Z)-3-(5-((5-methoxy-1H-indol-3-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)benzoic acid can be considered as lead compounds for further development of more potent and safe antibacterial and antifungal agents.
PB  - Basel: MDPI
T2  - Molecules
T1  - Synthesis, Biological Evaluation and Molecular Docking Studies of 5-Indolylmethylen-4-oxo-2-thioxothiazolidine Derivatives.
IS  - 3
VL  - 27
DO  - 10.3390/molecules27031068
SP  - 1068
ER  - 

@article{
author = "Horishny, Volodymyr and Geronikaki, Athina and Kartsev, Victor and Matiychuk, Vasyl and Petrou, Anthi and Pogodin, Pavel and Poroikov, Vladimir and Papadopoulou, Theodora A and Vizirianakis, Ioannis S and Kostić, Marina and Ivanov, Marija and Soković, Marina",
year = "2022",
abstract = "BACKGROUND Infectious diseases represent a significant global strain on public health security and impact on socio-economic stability all over the world. The increasing resistance to the current antimicrobial treatment has resulted in the crucial need for the discovery and development of novel entities for the infectious treatment with different modes of action that could target both sensitive and resistant strains. METHODS Compounds were synthesized using the classical organic chemistry methods. Prediction of biological activity spectra was carried out using PASS and PASS-based web applications. Pharmacophore modeling in LigandScout software was used for quantitative modeling of the antibacterial activity. Antimicrobial activity was evaluated using the microdilution method. AutoDock 4.2® software was used to elucidate probable bacterial and fungal molecular targets of the studied compounds. RESULTS All compounds exhibited better antibacterial potency than ampicillin against all bacteria tested. Three compounds were tested against resistant strains MRSA, P. aeruginosa and E. coli and were found to be more potent than MRSA than reference drugs. All compounds demonstrated a higher degree of antifungal activity than the reference drugs bifonazole (6-17-fold) and ketoconazole (13-52-fold). Three of the most active compounds could be considered for further development of the new, more potent antimicrobial agents. CONCLUSION Compounds 5b (Z)-3-(3-hydroxyphenyl)-5-((1-methyl-1H-indol-3-yl)methylene)-2-thioxothiazolidin-4-one and 5g (Z)-3-[5-(1H-Indol-3-ylmethylene)-4-oxo-2-thioxo-thiazolidin-3-yl]-benzoic acid as well as 5h (Z)-3-(5-((5-methoxy-1H-indol-3-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)benzoic acid can be considered as lead compounds for further development of more potent and safe antibacterial and antifungal agents.",
publisher = "Basel: MDPI",
journal = "Molecules",
title = "Synthesis, Biological Evaluation and Molecular Docking Studies of 5-Indolylmethylen-4-oxo-2-thioxothiazolidine Derivatives.",
number = "3",
volume = "27",
doi = "10.3390/molecules27031068",
pages = "1068"
}

Horishny, V., Geronikaki, A., Kartsev, V., Matiychuk, V., Petrou, A., Pogodin, P., Poroikov, V., Papadopoulou, T. A., Vizirianakis, I. S., Kostić, M., Ivanov, M.,& Soković, M.. (2022). Synthesis, Biological Evaluation and Molecular Docking Studies of 5-Indolylmethylen-4-oxo-2-thioxothiazolidine Derivatives.. in Molecules
Basel: MDPI., 27(3), 1068.
https://doi.org/10.3390/molecules27031068

Horishny V, Geronikaki A, Kartsev V, Matiychuk V, Petrou A, Pogodin P, Poroikov V, Papadopoulou TA, Vizirianakis IS, Kostić M, Ivanov M, Soković M. Synthesis, Biological Evaluation and Molecular Docking Studies of 5-Indolylmethylen-4-oxo-2-thioxothiazolidine Derivatives.. in Molecules. 2022;27(3):1068.
doi:10.3390/molecules27031068 .

Horishny, Volodymyr, Geronikaki, Athina, Kartsev, Victor, Matiychuk, Vasyl, Petrou, Anthi, Pogodin, Pavel, Poroikov, Vladimir, Papadopoulou, Theodora A, Vizirianakis, Ioannis S, Kostić, Marina, Ivanov, Marija, Soković, Marina, "Synthesis, Biological Evaluation and Molecular Docking Studies of 5-Indolylmethylen-4-oxo-2-thioxothiazolidine Derivatives." in Molecules, 27, no. 3 (2022):1068,
https://doi.org/10.3390/molecules27031068 . .

TY  - JOUR
AU  - Haroun, Michelyne
AU  - Tratrat, Christophe
AU  - Kolokotroni, Aggeliki
AU  - Petrou, Anthi
AU  - Geronikaki, Athina
AU  - Ivanov, Marija
AU  - Kostić, Marina
AU  - Soković, Marina
AU  - Carazo, Alejandro
AU  - Mladěnka, Přemysl
AU  - Sreeharsha, Nagaraja
AU  - Venugopala, Katharigatta N.
AU  - Nair, Anroop B.
AU  - Elsewedy, Heba S.
PY  - 2021
UR  - https://www.mdpi.com/2079-6382/10/3/309
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4196
AB  - In this study, we report the design, synthesis, computational and experimental evaluation of the antimicrobial activity, as well as docking studies of new 5-methylthiazole based thiazolidinones. All compounds demonstrated antibacterial efficacy, some of which (1, 4, 10 and 13) exhibited good activity against E. coli and B. cereus. The evaluation of antibacterial activity against three resistant strains, MRSA, P. aeruginosa and E. coli, revealed that compound 12 showed the best activity, higher than reference drugs ampicillin and streptomycin, which were inactive or exhibited only bacteriostatic activity against MRSA, respectively. Ten out of fifteen compounds demonstrated higher potency than reference drugs against a resistant strain of E. coli, which appeared to be the most sensitive species to our compounds. Compounds 8, 13 and 14 applied in a concentration equal to MIC reduced P. aeruginosa biofilm formation by more than 50%. All compounds displayed antifungal activity, with compound 10 being the most active. The majority of compounds showed better activity than ketoconazole against almost all fungal strains. In order to elucidate the mechanism of antibacterial and antifungal activities, molecular docking studies on E. coli Mur B and C. albicans CYP51 and dihydrofolate reductase were performed. Docking analysis of E. coli MurB indicated a probable involvement of MurB inhibition in the antibacterial mechanism of tested compounds while docking to 14α-lanosterol demethylase (CYP51) and tetrahydrofolate reductase of Candida albicans suggested that probable involvement of inhibition of CYP51 reductase in the antifungal activity of the compounds. Potential toxicity toward human cells is also reported.
PB  - MDPI AG
T2  - Antibiotics
T1  - 5-Benzyliden-2-(5-methylthiazol-2-ylimino)thiazolidin-4-ones as Antimicrobial Agents. Design, Synthesis, Biological Evaluation and Molecular Docking Studies
IS  - 3
VL  - 10
DO  - 10.3390/antibiotics10030309
SP  - 309
ER  - 

@article{
author = "Haroun, Michelyne and Tratrat, Christophe and Kolokotroni, Aggeliki and Petrou, Anthi and Geronikaki, Athina and Ivanov, Marija and Kostić, Marina and Soković, Marina and Carazo, Alejandro and Mladěnka, Přemysl and Sreeharsha, Nagaraja and Venugopala, Katharigatta N. and Nair, Anroop B. and Elsewedy, Heba S.",
year = "2021",
abstract = "In this study, we report the design, synthesis, computational and experimental evaluation of the antimicrobial activity, as well as docking studies of new 5-methylthiazole based thiazolidinones. All compounds demonstrated antibacterial efficacy, some of which (1, 4, 10 and 13) exhibited good activity against E. coli and B. cereus. The evaluation of antibacterial activity against three resistant strains, MRSA, P. aeruginosa and E. coli, revealed that compound 12 showed the best activity, higher than reference drugs ampicillin and streptomycin, which were inactive or exhibited only bacteriostatic activity against MRSA, respectively. Ten out of fifteen compounds demonstrated higher potency than reference drugs against a resistant strain of E. coli, which appeared to be the most sensitive species to our compounds. Compounds 8, 13 and 14 applied in a concentration equal to MIC reduced P. aeruginosa biofilm formation by more than 50%. All compounds displayed antifungal activity, with compound 10 being the most active. The majority of compounds showed better activity than ketoconazole against almost all fungal strains. In order to elucidate the mechanism of antibacterial and antifungal activities, molecular docking studies on E. coli Mur B and C. albicans CYP51 and dihydrofolate reductase were performed. Docking analysis of E. coli MurB indicated a probable involvement of MurB inhibition in the antibacterial mechanism of tested compounds while docking to 14α-lanosterol demethylase (CYP51) and tetrahydrofolate reductase of Candida albicans suggested that probable involvement of inhibition of CYP51 reductase in the antifungal activity of the compounds. Potential toxicity toward human cells is also reported.",
publisher = "MDPI AG",
journal = "Antibiotics",
title = "5-Benzyliden-2-(5-methylthiazol-2-ylimino)thiazolidin-4-ones as Antimicrobial Agents. Design, Synthesis, Biological Evaluation and Molecular Docking Studies",
number = "3",
volume = "10",
doi = "10.3390/antibiotics10030309",
pages = "309"
}

Haroun, M., Tratrat, C., Kolokotroni, A., Petrou, A., Geronikaki, A., Ivanov, M., Kostić, M., Soković, M., Carazo, A., Mladěnka, P., Sreeharsha, N., Venugopala, K. N., Nair, A. B.,& Elsewedy, H. S.. (2021). 5-Benzyliden-2-(5-methylthiazol-2-ylimino)thiazolidin-4-ones as Antimicrobial Agents. Design, Synthesis, Biological Evaluation and Molecular Docking Studies. in Antibiotics
MDPI AG., 10(3), 309.
https://doi.org/10.3390/antibiotics10030309

Haroun M, Tratrat C, Kolokotroni A, Petrou A, Geronikaki A, Ivanov M, Kostić M, Soković M, Carazo A, Mladěnka P, Sreeharsha N, Venugopala KN, Nair AB, Elsewedy HS. 5-Benzyliden-2-(5-methylthiazol-2-ylimino)thiazolidin-4-ones as Antimicrobial Agents. Design, Synthesis, Biological Evaluation and Molecular Docking Studies. in Antibiotics. 2021;10(3):309.
doi:10.3390/antibiotics10030309 .

Haroun, Michelyne, Tratrat, Christophe, Kolokotroni, Aggeliki, Petrou, Anthi, Geronikaki, Athina, Ivanov, Marija, Kostić, Marina, Soković, Marina, Carazo, Alejandro, Mladěnka, Přemysl, Sreeharsha, Nagaraja, Venugopala, Katharigatta N., Nair, Anroop B., Elsewedy, Heba S., "5-Benzyliden-2-(5-methylthiazol-2-ylimino)thiazolidin-4-ones as Antimicrobial Agents. Design, Synthesis, Biological Evaluation and Molecular Docking Studies" in Antibiotics, 10, no. 3 (2021):309,
https://doi.org/10.3390/antibiotics10030309 . .

TY  - JOUR
AU  - Haroun, Michelyne
AU  - Tratrat, Christophe
AU  - Petrou, Anthi
AU  - Geronikaki, Athina
AU  - Ivanov, Marija
AU  - Ćirić, Ana
AU  - Soković, Marina
AU  - Nagaraja, Sreeharsha
AU  - Narayanaswamy Venugopala, Katharigatta
AU  - Balachandran Nair, Anroop
AU  - Elsewedy, Heba
AU  - Kochkar, Hafedh
PY  - 2021
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4299
AB  - Background: Infectious diseases still affect large populations causing significant morbidity
and mortality. Bacterial and fungal infections for centuries were the main factors of death and
disability of millions of humans. Despite the progress in the control of infectious diseases, the
appearance of resistance of microbes to existing drugs creates the need for the development of new
effective antimicrobial agents. In an attempt to improve the antibacterial activity of previously
synthesized compounds modifications to their structures were performed. Methods: Nineteen
thiazolidinone derivatives with 6-Cl, 4-OMe, 6-CN, 6-adamantan, 4-Me, 6-adamantan substituents at
benzothiazole ring were synthesized and evaluated against panel of four bacterial strains S. aureus,
L. monocytogenes, E. coli and S. typhimirium and three resistant strains MRSA, E. coli and P. aeruginosa
in order to improve activity of previously evaluated 6-OCF3
-benzothiazole-based thiazolidinones.
The evaluation of minimum inhibitory and minimum bactericidal concentration was determined by
microdilution method. As reference compounds ampicillin and streptomycin were used. Results:
All compounds showed antibacterial activity with MIC in range of 0.12–0.75 mg/mL and MBC at
0.25–>1.00 mg/mL The most active compound among all tested appeared to be compound 18, with
MIC at 0.10 mg/mL and MBC at 0.12 mg/mL against P. aeruginosa. as well as against resistant strain
P. aeruginosa with MIC at 0.06 mg/mL and MBC at 0.12 mg/mL almost equipotent with streptomycin
and better than ampicillin. Docking studies predicted that the inhibition of LD-carboxypeptidase is
probably the possible mechanism of antibacterial activity of tested compounds. Conclusion: The best
improvement of antibacterial activity after modifications was achieved by replacement of 6-OCF3
substituent in benzothiazole moiety by 6-Cl against S. aureus, MRSA and resistant strain of E. coli by
2.5 folds, while against L. monocytogenes and S. typhimirium from 4 to 5 folds.
PB  - MDPI
T2  - Molecules
T1  - Exploration of the Antimicrobial Effects of Benzothiazolylthiazolidin-4-One and In Silico Mechanistic Investigation
IS  - 13
VL  - 26
DO  - 10.3390/molecules26134061
SP  - 4061
ER  - 

@article{
author = "Haroun, Michelyne and Tratrat, Christophe and Petrou, Anthi and Geronikaki, Athina and Ivanov, Marija and Ćirić, Ana and Soković, Marina and Nagaraja, Sreeharsha and Narayanaswamy Venugopala, Katharigatta and Balachandran Nair, Anroop and Elsewedy, Heba and Kochkar, Hafedh",
year = "2021",
abstract = "Background: Infectious diseases still affect large populations causing significant morbidity
and mortality. Bacterial and fungal infections for centuries were the main factors of death and
disability of millions of humans. Despite the progress in the control of infectious diseases, the
appearance of resistance of microbes to existing drugs creates the need for the development of new
effective antimicrobial agents. In an attempt to improve the antibacterial activity of previously
synthesized compounds modifications to their structures were performed. Methods: Nineteen
thiazolidinone derivatives with 6-Cl, 4-OMe, 6-CN, 6-adamantan, 4-Me, 6-adamantan substituents at
benzothiazole ring were synthesized and evaluated against panel of four bacterial strains S. aureus,
L. monocytogenes, E. coli and S. typhimirium and three resistant strains MRSA, E. coli and P. aeruginosa
in order to improve activity of previously evaluated 6-OCF3
-benzothiazole-based thiazolidinones.
The evaluation of minimum inhibitory and minimum bactericidal concentration was determined by
microdilution method. As reference compounds ampicillin and streptomycin were used. Results:
All compounds showed antibacterial activity with MIC in range of 0.12–0.75 mg/mL and MBC at
0.25–>1.00 mg/mL The most active compound among all tested appeared to be compound 18, with
MIC at 0.10 mg/mL and MBC at 0.12 mg/mL against P. aeruginosa. as well as against resistant strain
P. aeruginosa with MIC at 0.06 mg/mL and MBC at 0.12 mg/mL almost equipotent with streptomycin
and better than ampicillin. Docking studies predicted that the inhibition of LD-carboxypeptidase is
probably the possible mechanism of antibacterial activity of tested compounds. Conclusion: The best
improvement of antibacterial activity after modifications was achieved by replacement of 6-OCF3
substituent in benzothiazole moiety by 6-Cl against S. aureus, MRSA and resistant strain of E. coli by
2.5 folds, while against L. monocytogenes and S. typhimirium from 4 to 5 folds.",
publisher = "MDPI",
journal = "Molecules",
title = "Exploration of the Antimicrobial Effects of Benzothiazolylthiazolidin-4-One and In Silico Mechanistic Investigation",
number = "13",
volume = "26",
doi = "10.3390/molecules26134061",
pages = "4061"
}

Haroun, M., Tratrat, C., Petrou, A., Geronikaki, A., Ivanov, M., Ćirić, A., Soković, M., Nagaraja, S., Narayanaswamy Venugopala, K., Balachandran Nair, A., Elsewedy, H.,& Kochkar, H.. (2021). Exploration of the Antimicrobial Effects of Benzothiazolylthiazolidin-4-One and In Silico Mechanistic Investigation. in Molecules
MDPI., 26(13), 4061.
https://doi.org/10.3390/molecules26134061

Haroun M, Tratrat C, Petrou A, Geronikaki A, Ivanov M, Ćirić A, Soković M, Nagaraja S, Narayanaswamy Venugopala K, Balachandran Nair A, Elsewedy H, Kochkar H. Exploration of the Antimicrobial Effects of Benzothiazolylthiazolidin-4-One and In Silico Mechanistic Investigation. in Molecules. 2021;26(13):4061.
doi:10.3390/molecules26134061 .

Haroun, Michelyne, Tratrat, Christophe, Petrou, Anthi, Geronikaki, Athina, Ivanov, Marija, Ćirić, Ana, Soković, Marina, Nagaraja, Sreeharsha, Narayanaswamy Venugopala, Katharigatta, Balachandran Nair, Anroop, Elsewedy, Heba, Kochkar, Hafedh, "Exploration of the Antimicrobial Effects of Benzothiazolylthiazolidin-4-One and In Silico Mechanistic Investigation" in Molecules, 26, no. 13 (2021):4061,
https://doi.org/10.3390/molecules26134061 . .

TY  - JOUR
AU  - Zveaghintseva, Marina
AU  - Stingaci, Eugenia
AU  - Pogrebnoi, Sergei
AU  - Smetanscaia, Anastasia
AU  - Valica, Vladimir
AU  - Uncu, Livia
AU  - Kravtsov, Victor
AU  - Melnik, Elena
AU  - Petrou, Anthi
AU  - Glamočlija, Jasmina
AU  - Soković, Marina
AU  - Carazo, Alejandro
AU  - Mladěnka, Přemysl
AU  - Poroikov, Vladimir
AU  - Geronikaki, Athina
AU  - Macaev, Fliur
PY  - 2021
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4305
AB  - Herein we report the synthesis of some new 1H-1,2,4-triazole functionalized chromenols
(3a–3n) via tandem reactions of 1-(alkyl/aryl)-2-(1H-1,2,4-triazole-1-yl) with salicylic aldehydes and
the evaluation of their antifungal activity. In silico prediction of biological activity spectra with
computer program PASS indicate that the compounds have a high novelty compared to the known
antifungal agents. We did not find any close analog among the over 580,000 pharmaceutical agents
in the Cortellis Drug Discovery Intelligence database at the similarity cutoff of 70%. The evaluation
of antifungal activity in vitro revealed that the highest activity was exhibited by compound 3k,
followed by 3n. Their MIC values for different fungi were 22.1–184.2 and 71.3–199.8  M, respectively.
Twelve from fourteen tested compounds were more active than the reference drugs ketoconazole and
bifonazole. The most sensitive fungus appeared to be Trichoderma viride, while Aspergillus fumigatus
was the most resistant one. It was found that the presence of the 2-(tert-butyl)-2H-chromen-2-ol
substituent on the 4th position of the triazole ring is very beneficial for antifungal activity. Molecular
docking studies on C. albicans sterol 14 -demethylase (CYP51) and DNA topoisomerase IV were used
to predict the mechanism of antifungal activities. According to the docking results, the inhibition
of CYP51 is a putative mechanism of antifungal activity of the novel chromenol derivatives. We
also showed that most active compounds have a low cytotoxicity, which allows us to consider them
promising antifungal agents for the subsequent testing activity in in vivo assays.
PB  - Basel: MDPI
T2  - Molecules
T1  - Chromenol Derivatives as Novel Antifungal Agents: Synthesis, In Silico and In Vitro Evaluation
IS  - 14
VL  - 26
DO  - 10.3390/molecules26144304
SP  - 4304
ER  - 

@article{
author = "Zveaghintseva, Marina and Stingaci, Eugenia and Pogrebnoi, Sergei and Smetanscaia, Anastasia and Valica, Vladimir and Uncu, Livia and Kravtsov, Victor and Melnik, Elena and Petrou, Anthi and Glamočlija, Jasmina and Soković, Marina and Carazo, Alejandro and Mladěnka, Přemysl and Poroikov, Vladimir and Geronikaki, Athina and Macaev, Fliur",
year = "2021",
abstract = "Herein we report the synthesis of some new 1H-1,2,4-triazole functionalized chromenols
(3a–3n) via tandem reactions of 1-(alkyl/aryl)-2-(1H-1,2,4-triazole-1-yl) with salicylic aldehydes and
the evaluation of their antifungal activity. In silico prediction of biological activity spectra with
computer program PASS indicate that the compounds have a high novelty compared to the known
antifungal agents. We did not find any close analog among the over 580,000 pharmaceutical agents
in the Cortellis Drug Discovery Intelligence database at the similarity cutoff of 70%. The evaluation
of antifungal activity in vitro revealed that the highest activity was exhibited by compound 3k,
followed by 3n. Their MIC values for different fungi were 22.1–184.2 and 71.3–199.8  M, respectively.
Twelve from fourteen tested compounds were more active than the reference drugs ketoconazole and
bifonazole. The most sensitive fungus appeared to be Trichoderma viride, while Aspergillus fumigatus
was the most resistant one. It was found that the presence of the 2-(tert-butyl)-2H-chromen-2-ol
substituent on the 4th position of the triazole ring is very beneficial for antifungal activity. Molecular
docking studies on C. albicans sterol 14 -demethylase (CYP51) and DNA topoisomerase IV were used
to predict the mechanism of antifungal activities. According to the docking results, the inhibition
of CYP51 is a putative mechanism of antifungal activity of the novel chromenol derivatives. We
also showed that most active compounds have a low cytotoxicity, which allows us to consider them
promising antifungal agents for the subsequent testing activity in in vivo assays.",
publisher = "Basel: MDPI",
journal = "Molecules",
title = "Chromenol Derivatives as Novel Antifungal Agents: Synthesis, In Silico and In Vitro Evaluation",
number = "14",
volume = "26",
doi = "10.3390/molecules26144304",
pages = "4304"
}

Zveaghintseva, M., Stingaci, E., Pogrebnoi, S., Smetanscaia, A., Valica, V., Uncu, L., Kravtsov, V., Melnik, E., Petrou, A., Glamočlija, J., Soković, M., Carazo, A., Mladěnka, P., Poroikov, V., Geronikaki, A.,& Macaev, F.. (2021). Chromenol Derivatives as Novel Antifungal Agents: Synthesis, In Silico and In Vitro Evaluation. in Molecules
Basel: MDPI., 26(14), 4304.
https://doi.org/10.3390/molecules26144304

Zveaghintseva M, Stingaci E, Pogrebnoi S, Smetanscaia A, Valica V, Uncu L, Kravtsov V, Melnik E, Petrou A, Glamočlija J, Soković M, Carazo A, Mladěnka P, Poroikov V, Geronikaki A, Macaev F. Chromenol Derivatives as Novel Antifungal Agents: Synthesis, In Silico and In Vitro Evaluation. in Molecules. 2021;26(14):4304.
doi:10.3390/molecules26144304 .

Zveaghintseva, Marina, Stingaci, Eugenia, Pogrebnoi, Sergei, Smetanscaia, Anastasia, Valica, Vladimir, Uncu, Livia, Kravtsov, Victor, Melnik, Elena, Petrou, Anthi, Glamočlija, Jasmina, Soković, Marina, Carazo, Alejandro, Mladěnka, Přemysl, Poroikov, Vladimir, Geronikaki, Athina, Macaev, Fliur, "Chromenol Derivatives as Novel Antifungal Agents: Synthesis, In Silico and In Vitro Evaluation" in Molecules, 26, no. 14 (2021):4304,
https://doi.org/10.3390/molecules26144304 . .

TY  - JOUR
AU  - Kartsev, Victor
AU  - Lichitsky, Boris
AU  - Geronikaki, Athina
AU  - Petrou, Anthi
AU  - Ivanov, Marija
AU  - Kostić, Marina
AU  - Radanović, Oliver
AU  - Soković, Marina
PY  - 2019
UR  - http://xlink.rsc.org/?DOI=C8MD90056F
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3252
AB  - The authors regret that the author names were not displayed correctly on the original manuscript. The corrected list of authors for this paper is as shown above. The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.
T2  - MedChemComm
T2  - MedChemComm
T1  - Correction: Design, synthesis and antimicrobial activity of usnic acid derivatives (MedChemComm (2018) 9 (870–882) DOI: 10.1039/C8MD00076J)
IS  - 1
VL  - 10
DO  - 10.1039/C8MD90056F
SP  - 180
ER  - 

@article{
author = "Kartsev, Victor and Lichitsky, Boris and Geronikaki, Athina and Petrou, Anthi and Ivanov, Marija and Kostić, Marina and Radanović, Oliver and Soković, Marina",
year = "2019",
abstract = "The authors regret that the author names were not displayed correctly on the original manuscript. The corrected list of authors for this paper is as shown above. The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.",
journal = "MedChemComm, MedChemComm",
title = "Correction: Design, synthesis and antimicrobial activity of usnic acid derivatives (MedChemComm (2018) 9 (870–882) DOI: 10.1039/C8MD00076J)",
number = "1",
volume = "10",
doi = "10.1039/C8MD90056F",
pages = "180"
}

Kartsev, V., Lichitsky, B., Geronikaki, A., Petrou, A., Ivanov, M., Kostić, M., Radanović, O.,& Soković, M.. (2019). Correction: Design, synthesis and antimicrobial activity of usnic acid derivatives (MedChemComm (2018) 9 (870–882) DOI: 10.1039/C8MD00076J). in MedChemComm, 10(1), 180.
https://doi.org/10.1039/C8MD90056F

Kartsev V, Lichitsky B, Geronikaki A, Petrou A, Ivanov M, Kostić M, Radanović O, Soković M. Correction: Design, synthesis and antimicrobial activity of usnic acid derivatives (MedChemComm (2018) 9 (870–882) DOI: 10.1039/C8MD00076J). in MedChemComm. 2019;10(1):180.
doi:10.1039/C8MD90056F .

Kartsev, Victor, Lichitsky, Boris, Geronikaki, Athina, Petrou, Anthi, Ivanov, Marija, Kostić, Marina, Radanović, Oliver, Soković, Marina, "Correction: Design, synthesis and antimicrobial activity of usnic acid derivatives (MedChemComm (2018) 9 (870–882) DOI: 10.1039/C8MD00076J)" in MedChemComm, 10, no. 1 (2019):180,
https://doi.org/10.1039/C8MD90056F . .

TY  - JOUR
AU  - Tratrat, Christophe
AU  - Haroun, Michelyne
AU  - Xenikakis, Iakovos
AU  - Liaras, Konstantinos
AU  - Tsolaki, Evangelia
AU  - Eleftheriou, Phaedra
AU  - Petrou, Anthi
AU  - Aldhubiab, Bandar
AU  - Attimarad, Mahesh
AU  - Venugopala, Katharigatta N.
AU  - Harsha, Sree
AU  - Elsewedy, Heba S.
AU  - Geronikaki, Athina
AU  - Soković, Marina
PY  - 2019
UR  - http://www.eurekaselect.com/169442/article
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3358
AB  - BACKGROUND Thiazole derivates as well as chalcones, are very important scaffold for medicinal chemistry. Literature survey revealed that they possess wide spectrum of biological activities among which are anti-inflammatory and antimicrobial. OBJECTIVES The current studies describe the synthesis and evaluation of antimicrobial activity of twenty eight novel thiazole-based chalcones. METHODS The designed compounds were synthesized using classical methods of organic synthesis. The in vivo evaluation of antimicrobial activity was performed by microdilution method. RESULTS All compounds have shown antibacterial properties better than that of ampicillin and in many cases better than streptomycin. As far as the antifungal activity is concerned, all compounds possess much higher activity than reference drugs bifonazole and ketoconazole. The most sensitive bacterial species was B. cereus (MIC 6.5-28.4 µmol × 10-2/mL and MBC 14.2-105.0 µmol × 10-2/mL) while the most resistant ones were L. monocytogenes (MIC 21.4-113.6 µmol × 10-2/mL) and E. coli (MIC 10.7- 113.6 µmol × 10-2/mL) and MBC at 42.7-358.6 µmol × 10-2/mL and 21.4-247.2 µmol × 10-2/mL, respectively. All the compounds exhibited antibacterial activity against the three resistant strains, MRSA, P. aeruginosa and E.coli. with MIC and MBC in the range of 0.65-11.00 µmol/mL × 10-2 and 1.30-16.50 µmol/mL × 10-2. Docking studies were performed. CONCLUSION Twenty-eight novel thiazole-based chalcones were designed, synthesized and evaluated for antimicrobial activity. The results showed that these derivatives could be lead compounds in search of new potent antimicrobial agents. Docking studies indicated that DNA gyrase, GyrB and MurA inhibition may explain the antibacterial activity.
T2  - Current Topics in Medicinal Chemistry
T1  - Design, Synthesis, Evaluation of Antimicrobial Activity and Docking Studies of New Thiazole-based Chalcones.
IS  - 5
VL  - 19
DO  - 10.2174/1568026619666190129121933
SP  - 356
EP  - 375
ER  - 

@article{
author = "Tratrat, Christophe and Haroun, Michelyne and Xenikakis, Iakovos and Liaras, Konstantinos and Tsolaki, Evangelia and Eleftheriou, Phaedra and Petrou, Anthi and Aldhubiab, Bandar and Attimarad, Mahesh and Venugopala, Katharigatta N. and Harsha, Sree and Elsewedy, Heba S. and Geronikaki, Athina and Soković, Marina",
year = "2019",
abstract = "BACKGROUND Thiazole derivates as well as chalcones, are very important scaffold for medicinal chemistry. Literature survey revealed that they possess wide spectrum of biological activities among which are anti-inflammatory and antimicrobial. OBJECTIVES The current studies describe the synthesis and evaluation of antimicrobial activity of twenty eight novel thiazole-based chalcones. METHODS The designed compounds were synthesized using classical methods of organic synthesis. The in vivo evaluation of antimicrobial activity was performed by microdilution method. RESULTS All compounds have shown antibacterial properties better than that of ampicillin and in many cases better than streptomycin. As far as the antifungal activity is concerned, all compounds possess much higher activity than reference drugs bifonazole and ketoconazole. The most sensitive bacterial species was B. cereus (MIC 6.5-28.4 µmol × 10-2/mL and MBC 14.2-105.0 µmol × 10-2/mL) while the most resistant ones were L. monocytogenes (MIC 21.4-113.6 µmol × 10-2/mL) and E. coli (MIC 10.7- 113.6 µmol × 10-2/mL) and MBC at 42.7-358.6 µmol × 10-2/mL and 21.4-247.2 µmol × 10-2/mL, respectively. All the compounds exhibited antibacterial activity against the three resistant strains, MRSA, P. aeruginosa and E.coli. with MIC and MBC in the range of 0.65-11.00 µmol/mL × 10-2 and 1.30-16.50 µmol/mL × 10-2. Docking studies were performed. CONCLUSION Twenty-eight novel thiazole-based chalcones were designed, synthesized and evaluated for antimicrobial activity. The results showed that these derivatives could be lead compounds in search of new potent antimicrobial agents. Docking studies indicated that DNA gyrase, GyrB and MurA inhibition may explain the antibacterial activity.",
journal = "Current Topics in Medicinal Chemistry",
title = "Design, Synthesis, Evaluation of Antimicrobial Activity and Docking Studies of New Thiazole-based Chalcones.",
number = "5",
volume = "19",
doi = "10.2174/1568026619666190129121933",
pages = "356-375"
}

Tratrat, C., Haroun, M., Xenikakis, I., Liaras, K., Tsolaki, E., Eleftheriou, P., Petrou, A., Aldhubiab, B., Attimarad, M., Venugopala, K. N., Harsha, S., Elsewedy, H. S., Geronikaki, A.,& Soković, M.. (2019). Design, Synthesis, Evaluation of Antimicrobial Activity and Docking Studies of New Thiazole-based Chalcones.. in Current Topics in Medicinal Chemistry, 19(5), 356-375.
https://doi.org/10.2174/1568026619666190129121933

Tratrat C, Haroun M, Xenikakis I, Liaras K, Tsolaki E, Eleftheriou P, Petrou A, Aldhubiab B, Attimarad M, Venugopala KN, Harsha S, Elsewedy HS, Geronikaki A, Soković M. Design, Synthesis, Evaluation of Antimicrobial Activity and Docking Studies of New Thiazole-based Chalcones.. in Current Topics in Medicinal Chemistry. 2019;19(5):356-375.
doi:10.2174/1568026619666190129121933 .

Tratrat, Christophe, Haroun, Michelyne, Xenikakis, Iakovos, Liaras, Konstantinos, Tsolaki, Evangelia, Eleftheriou, Phaedra, Petrou, Anthi, Aldhubiab, Bandar, Attimarad, Mahesh, Venugopala, Katharigatta N., Harsha, Sree, Elsewedy, Heba S., Geronikaki, Athina, Soković, Marina, "Design, Synthesis, Evaluation of Antimicrobial Activity and Docking Studies of New Thiazole-based Chalcones." in Current Topics in Medicinal Chemistry, 19, no. 5 (2019):356-375,
https://doi.org/10.2174/1568026619666190129121933 . .

TY  - JOUR
AU  - Merlani, Maia
AU  - Barbakadze, Vakhtang
AU  - Amiranashvili, Lela
AU  - Gogilashvili, Lali
AU  - Poroikov, Vladimir
AU  - Petrou, Anthi
AU  - Geronikaki, Athina
AU  - Ćirić, Ana
AU  - Glamočlija, Jasmina
AU  - Soković, Marina
PY  - 2019
UR  - http://www.eurekaselect.com/169251/article
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3346
AB  - BACKGROUND Phenolic acids (caffeic-, ferulic and p-coumaric acid) are widely distributed in the plant kingdom and exhibit broad spectrum of biological activities, including antimicrobial activity. OBJECTIVE The goal of this paper is the synthesis of some caffeic acid derivatives selected based on computer-aided predictions and evaluate their in vitro antimicrobial properties against Gram positive and Gram negative bacteria and also a series of fungi. METHODS In silico prediction of biological activity was used to identify the most promising structures for synthesis and biological testing, and the putative mechanisms of their antimicrobial action. The designed compounds were synthesized using classical organic synthesis methods. The antimicrobial activity was studied using microdilution method. RESULTS Twelve tested compounds have shown good antibacterial activity. Five out of twelve tested compounds appeared to be more active than the reference drugs ampicillin and streptomycin. Despite that all compounds exhibited good activity against all bacteria tested, the sensitivity of bacteria towards compounds in general was different. The evaluation of antifungal activity revealed that all compounds were more active than ketoconazole, while seven compounds (2, 3, 4, 5, 7, 8 and 12) appeared to be more active than bifonazole. Docking results indicate that gyrase inhibition is the putative mechanism of antibacterial action while the inhibition of 14α-demethylase may be responsible for antifungal action. Prediction of cytotoxicity by PROTOX showed that compounds are not toxic (LD50 1000-2000 mg/kg). CONCLUSION Thirteen compounds, from which six are new ones, were synthesized, and twelve compounds were tested for antimicrobial activity. The studied compounds appeared to be promising potent and non-toxic antimicrobials, which could be considered as leads for new pharmaceutical agents.
T2  - Current Topics in Medicinal Chemistry
T1  - New Caffeic Acid Derivatives as Antimicrobial Agents: Design, Synthesis, Evaluation and Docking.
IS  - 4
VL  - 19
DO  - 10.2174/1568026619666190122152957
SP  - 292
EP  - 304
ER  - 

@article{
author = "Merlani, Maia and Barbakadze, Vakhtang and Amiranashvili, Lela and Gogilashvili, Lali and Poroikov, Vladimir and Petrou, Anthi and Geronikaki, Athina and Ćirić, Ana and Glamočlija, Jasmina and Soković, Marina",
year = "2019",
abstract = "BACKGROUND Phenolic acids (caffeic-, ferulic and p-coumaric acid) are widely distributed in the plant kingdom and exhibit broad spectrum of biological activities, including antimicrobial activity. OBJECTIVE The goal of this paper is the synthesis of some caffeic acid derivatives selected based on computer-aided predictions and evaluate their in vitro antimicrobial properties against Gram positive and Gram negative bacteria and also a series of fungi. METHODS In silico prediction of biological activity was used to identify the most promising structures for synthesis and biological testing, and the putative mechanisms of their antimicrobial action. The designed compounds were synthesized using classical organic synthesis methods. The antimicrobial activity was studied using microdilution method. RESULTS Twelve tested compounds have shown good antibacterial activity. Five out of twelve tested compounds appeared to be more active than the reference drugs ampicillin and streptomycin. Despite that all compounds exhibited good activity against all bacteria tested, the sensitivity of bacteria towards compounds in general was different. The evaluation of antifungal activity revealed that all compounds were more active than ketoconazole, while seven compounds (2, 3, 4, 5, 7, 8 and 12) appeared to be more active than bifonazole. Docking results indicate that gyrase inhibition is the putative mechanism of antibacterial action while the inhibition of 14α-demethylase may be responsible for antifungal action. Prediction of cytotoxicity by PROTOX showed that compounds are not toxic (LD50 1000-2000 mg/kg). CONCLUSION Thirteen compounds, from which six are new ones, were synthesized, and twelve compounds were tested for antimicrobial activity. The studied compounds appeared to be promising potent and non-toxic antimicrobials, which could be considered as leads for new pharmaceutical agents.",
journal = "Current Topics in Medicinal Chemistry",
title = "New Caffeic Acid Derivatives as Antimicrobial Agents: Design, Synthesis, Evaluation and Docking.",
number = "4",
volume = "19",
doi = "10.2174/1568026619666190122152957",
pages = "292-304"
}

Merlani, M., Barbakadze, V., Amiranashvili, L., Gogilashvili, L., Poroikov, V., Petrou, A., Geronikaki, A., Ćirić, A., Glamočlija, J.,& Soković, M.. (2019). New Caffeic Acid Derivatives as Antimicrobial Agents: Design, Synthesis, Evaluation and Docking.. in Current Topics in Medicinal Chemistry, 19(4), 292-304.
https://doi.org/10.2174/1568026619666190122152957

Merlani M, Barbakadze V, Amiranashvili L, Gogilashvili L, Poroikov V, Petrou A, Geronikaki A, Ćirić A, Glamočlija J, Soković M. New Caffeic Acid Derivatives as Antimicrobial Agents: Design, Synthesis, Evaluation and Docking.. in Current Topics in Medicinal Chemistry. 2019;19(4):292-304.
doi:10.2174/1568026619666190122152957 .

Merlani, Maia, Barbakadze, Vakhtang, Amiranashvili, Lela, Gogilashvili, Lali, Poroikov, Vladimir, Petrou, Anthi, Geronikaki, Athina, Ćirić, Ana, Glamočlija, Jasmina, Soković, Marina, "New Caffeic Acid Derivatives as Antimicrobial Agents: Design, Synthesis, Evaluation and Docking." in Current Topics in Medicinal Chemistry, 19, no. 4 (2019):292-304,
https://doi.org/10.2174/1568026619666190122152957 . .

TY  - JOUR
AU  - Nadaraia, Nanuli Sh.
AU  - Amiranashvili, Lela Sh.
AU  - Merlani, Maia
AU  - Kakhabrishvili, Meri L.
AU  - Barbakadze, Nana N.
AU  - Geronikaki, Athina
AU  - Petrou, Anthi
AU  - Poroikov, Vladimir
AU  - Ćirić, Ana
AU  - Glamočlija, Jasmina
AU  - Soković, Marina
PY  - 2019
UR  - https://www.sciencedirect.com/science/article/pii/S0039128X19300376?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3274
AB  - Fourteen steroid compounds were in silico evaluated using computer program PASS as antimicrobial agents. The experimental studies evaluation revealed that all compounds have good antibacterial activity with MIC at range of 0.003-0.96 mg/mL and MBC 0.06-1.92 mg/mL. Almost all compounds except of compound 4 (3β-acetoxy-1/-p-chlorophenyl-3/-methyl-5α-androstano[17,16-d]pyrazoline) were more potent than Ampicillin, and they were equipotent or more potent than Streptomycine. All compounds exhibited good antifungal activity with MIC at 0.003-0.96 mg/mL and MFC at 0.006-1.92 mg/mL but with different sensitivity against fungi tested. According to docking studies 14-alpha demethylase inhibition may be responsible for antifungal activity. Prediction of toxicity by PROTOX and GUSAR revealed that compounds have low toxicity and can be considered as potential lead compounds for the further studies.
T2  - Steroids
T1  - Novel antimicrobial agents' discovery among the steroid derivatives.
VL  - 144
DO  - 10.1016/j.steroids.2019.02.012
SP  - 52
EP  - 65
ER  - 

@article{
author = "Nadaraia, Nanuli Sh. and Amiranashvili, Lela Sh. and Merlani, Maia and Kakhabrishvili, Meri L. and Barbakadze, Nana N. and Geronikaki, Athina and Petrou, Anthi and Poroikov, Vladimir and Ćirić, Ana and Glamočlija, Jasmina and Soković, Marina",
year = "2019",
abstract = "Fourteen steroid compounds were in silico evaluated using computer program PASS as antimicrobial agents. The experimental studies evaluation revealed that all compounds have good antibacterial activity with MIC at range of 0.003-0.96 mg/mL and MBC 0.06-1.92 mg/mL. Almost all compounds except of compound 4 (3β-acetoxy-1/-p-chlorophenyl-3/-methyl-5α-androstano[17,16-d]pyrazoline) were more potent than Ampicillin, and they were equipotent or more potent than Streptomycine. All compounds exhibited good antifungal activity with MIC at 0.003-0.96 mg/mL and MFC at 0.006-1.92 mg/mL but with different sensitivity against fungi tested. According to docking studies 14-alpha demethylase inhibition may be responsible for antifungal activity. Prediction of toxicity by PROTOX and GUSAR revealed that compounds have low toxicity and can be considered as potential lead compounds for the further studies.",
journal = "Steroids",
title = "Novel antimicrobial agents' discovery among the steroid derivatives.",
volume = "144",
doi = "10.1016/j.steroids.2019.02.012",
pages = "52-65"
}

Nadaraia, N. Sh., Amiranashvili, L. Sh., Merlani, M., Kakhabrishvili, M. L., Barbakadze, N. N., Geronikaki, A., Petrou, A., Poroikov, V., Ćirić, A., Glamočlija, J.,& Soković, M.. (2019). Novel antimicrobial agents' discovery among the steroid derivatives.. in Steroids, 144, 52-65.
https://doi.org/10.1016/j.steroids.2019.02.012

Nadaraia NS, Amiranashvili LS, Merlani M, Kakhabrishvili ML, Barbakadze NN, Geronikaki A, Petrou A, Poroikov V, Ćirić A, Glamočlija J, Soković M. Novel antimicrobial agents' discovery among the steroid derivatives.. in Steroids. 2019;144:52-65.
doi:10.1016/j.steroids.2019.02.012 .

Nadaraia, Nanuli Sh., Amiranashvili, Lela Sh., Merlani, Maia, Kakhabrishvili, Meri L., Barbakadze, Nana N., Geronikaki, Athina, Petrou, Anthi, Poroikov, Vladimir, Ćirić, Ana, Glamočlija, Jasmina, Soković, Marina, "Novel antimicrobial agents' discovery among the steroid derivatives." in Steroids, 144 (2019):52-65,
https://doi.org/10.1016/j.steroids.2019.02.012 . .

TY  - JOUR
AU  - Fesatidou, Maria
AU  - Zagaliotis, Panagiotis
AU  - Camoutsis, Charalampos
AU  - Petrou, Anthi
AU  - Eleftheriou, Phaedra
AU  - Tratrat, Christophe
AU  - Haroun, Micheline
AU  - Geronikaki, Athina
AU  - Ćirić, Ana
AU  - Soković, Marina
PY  - 2018
UR  - https://www.sciencedirect.com/science/article/pii/S0968089618310277?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3127
AB  - In continuation of our efforts to develop new compounds with antimicrobial properties we describe design, synthesis, molecular docking study and evaluation of antimicrobial activity of seventeen novel 2-{[5-(adamantan-1-yl)-1,3,4-thiadiazol-2-yl]-imino}-5-arylidene-1,3-thiazolidin-4-ones. All compounds showed antibacterial activity against eight Gram positive and Gram negative bacterial species. Twelve out of seventeen compounds were more potent than streptomycin and all compounds exhibited higher potency than ampicillin. Compounds were also tested against three resistant bacterial strains: MRSA, P. aeruginosa and E. coli. The best antibacterial potential against ATCC and resistant strains was observed for compound 8 (2-{[5-(adamantan-1-yl)-1,3,4-thiadiazol-2-yl]-imino}-5-(4-nitrobenzylidene)-1,3thiazolidin-4-one). The most sensitive bacterium appeared to be S. typhimirium, followed by B. cereus while L. monocitogenes and M. flavus were the most resistant. Compounds were also tested for their antifungal activity against eight fungal species. All compounds exhibited antifungal activity better than the reference drugs bifonazole and ketokonazole (3-115 times). It was found that compound 8 appeared again to be the most potent. Molecular docking studies on E. coli MurB, MurA as well as C. albicans CYP 51 and dihydrofolate reductase were used for the prediction of mechanism of antibacterial and antifungal activities confirming the experimental results.
T2  - Bioorganic & Medicinal Chemistry
T1  - 5-Adamantan thiadiazole-based thiazolidinones as antimicrobial agents. Design, synthesis, molecular docking and evaluation.
DO  - 10.1016/j.bmc.2018.08.004
ER  - 

@article{
author = "Fesatidou, Maria and Zagaliotis, Panagiotis and Camoutsis, Charalampos and Petrou, Anthi and Eleftheriou, Phaedra and Tratrat, Christophe and Haroun, Micheline and Geronikaki, Athina and Ćirić, Ana and Soković, Marina",
year = "2018",
abstract = "In continuation of our efforts to develop new compounds with antimicrobial properties we describe design, synthesis, molecular docking study and evaluation of antimicrobial activity of seventeen novel 2-{[5-(adamantan-1-yl)-1,3,4-thiadiazol-2-yl]-imino}-5-arylidene-1,3-thiazolidin-4-ones. All compounds showed antibacterial activity against eight Gram positive and Gram negative bacterial species. Twelve out of seventeen compounds were more potent than streptomycin and all compounds exhibited higher potency than ampicillin. Compounds were also tested against three resistant bacterial strains: MRSA, P. aeruginosa and E. coli. The best antibacterial potential against ATCC and resistant strains was observed for compound 8 (2-{[5-(adamantan-1-yl)-1,3,4-thiadiazol-2-yl]-imino}-5-(4-nitrobenzylidene)-1,3thiazolidin-4-one). The most sensitive bacterium appeared to be S. typhimirium, followed by B. cereus while L. monocitogenes and M. flavus were the most resistant. Compounds were also tested for their antifungal activity against eight fungal species. All compounds exhibited antifungal activity better than the reference drugs bifonazole and ketokonazole (3-115 times). It was found that compound 8 appeared again to be the most potent. Molecular docking studies on E. coli MurB, MurA as well as C. albicans CYP 51 and dihydrofolate reductase were used for the prediction of mechanism of antibacterial and antifungal activities confirming the experimental results.",
journal = "Bioorganic & Medicinal Chemistry",
title = "5-Adamantan thiadiazole-based thiazolidinones as antimicrobial agents. Design, synthesis, molecular docking and evaluation.",
doi = "10.1016/j.bmc.2018.08.004"
}

Fesatidou, M., Zagaliotis, P., Camoutsis, C., Petrou, A., Eleftheriou, P., Tratrat, C., Haroun, M., Geronikaki, A., Ćirić, A.,& Soković, M.. (2018). 5-Adamantan thiadiazole-based thiazolidinones as antimicrobial agents. Design, synthesis, molecular docking and evaluation.. in Bioorganic & Medicinal Chemistry.
https://doi.org/10.1016/j.bmc.2018.08.004

Fesatidou M, Zagaliotis P, Camoutsis C, Petrou A, Eleftheriou P, Tratrat C, Haroun M, Geronikaki A, Ćirić A, Soković M. 5-Adamantan thiadiazole-based thiazolidinones as antimicrobial agents. Design, synthesis, molecular docking and evaluation.. in Bioorganic & Medicinal Chemistry. 2018;.
doi:10.1016/j.bmc.2018.08.004 .

Fesatidou, Maria, Zagaliotis, Panagiotis, Camoutsis, Charalampos, Petrou, Anthi, Eleftheriou, Phaedra, Tratrat, Christophe, Haroun, Micheline, Geronikaki, Athina, Ćirić, Ana, Soković, Marina, "5-Adamantan thiadiazole-based thiazolidinones as antimicrobial agents. Design, synthesis, molecular docking and evaluation." in Bioorganic & Medicinal Chemistry (2018),
https://doi.org/10.1016/j.bmc.2018.08.004 . .

TY  - JOUR
AU  - Kartsev, Victor
AU  - Lichitsky, Boris
AU  - Geronikaki, Athina
AU  - Petrou, Anthi
AU  - Ivanov, Marija
AU  - Kostić, Marina
AU  - Radanović, Oliver
AU  - Soković, Marina
PY  - 2018
UR  - http://pubs.rsc.org/en/Content/ArticleLanding/2018/MD/C8MD00076J#!divAbstract
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3080
AB  - Usnic acid, a dibenzofuran, was originally isolated from lichens producing secondary metabolites, and is well known as an antibiotic, but is also endowed with several other interesting properties. Thus, the goal of this paper is the design of new usnic acid derivatives and evaluation of their antimicrobial activity. All newly synthesized compounds possess good antibacterial activity with MIC ranging from 1.02-50.93 × 10-2 mmol mL-1 and MBC from 2.05-70.57 × 10-2 mmol mL-1. The most sensitive bacterial species was Staphylococcus aureus, while Pseudomonas aeruginosa and Escherichia coli were the most resistant among the ATCC strains, and MRSA was the most resistant among all tested bacteria (ATCC and clinical isolates). Their antifungal activity was very strong (MIC = 0.35-7.53 × 10-2 mmol mL-1 and MFC = 0.70-15.05 × 10-2 mmol mL-1)-better than those of reference compounds and usnic acid itself. The most sensitive fungal species was Trichoderma viride, while Penicillium versicolor var. cyclopium appeared to be the most resistant. It should be mentioned that in general most of the compounds showed weaker antibacterial activity, but better antifungal properties than usnic acid itself. The results allow us to conclude that the title compounds are good lead compounds for novel more active antibacterial drugs. On the other hand, these compounds are very promising as antifungals.
T2  - MedChemComm
T2  - MedChemComm
T1  - Design, synthesis and antimicrobial activity of usnic acid derivatives
IS  - 5
VL  - 9
DO  - 10.1039/C8MD00076J
SP  - 870
EP  - 882
ER  - 

@article{
author = "Kartsev, Victor and Lichitsky, Boris and Geronikaki, Athina and Petrou, Anthi and Ivanov, Marija and Kostić, Marina and Radanović, Oliver and Soković, Marina",
year = "2018",
abstract = "Usnic acid, a dibenzofuran, was originally isolated from lichens producing secondary metabolites, and is well known as an antibiotic, but is also endowed with several other interesting properties. Thus, the goal of this paper is the design of new usnic acid derivatives and evaluation of their antimicrobial activity. All newly synthesized compounds possess good antibacterial activity with MIC ranging from 1.02-50.93 × 10-2 mmol mL-1 and MBC from 2.05-70.57 × 10-2 mmol mL-1. The most sensitive bacterial species was Staphylococcus aureus, while Pseudomonas aeruginosa and Escherichia coli were the most resistant among the ATCC strains, and MRSA was the most resistant among all tested bacteria (ATCC and clinical isolates). Their antifungal activity was very strong (MIC = 0.35-7.53 × 10-2 mmol mL-1 and MFC = 0.70-15.05 × 10-2 mmol mL-1)-better than those of reference compounds and usnic acid itself. The most sensitive fungal species was Trichoderma viride, while Penicillium versicolor var. cyclopium appeared to be the most resistant. It should be mentioned that in general most of the compounds showed weaker antibacterial activity, but better antifungal properties than usnic acid itself. The results allow us to conclude that the title compounds are good lead compounds for novel more active antibacterial drugs. On the other hand, these compounds are very promising as antifungals.",
journal = "MedChemComm, MedChemComm",
title = "Design, synthesis and antimicrobial activity of usnic acid derivatives",
number = "5",
volume = "9",
doi = "10.1039/C8MD00076J",
pages = "870-882"
}

Kartsev, V., Lichitsky, B., Geronikaki, A., Petrou, A., Ivanov, M., Kostić, M., Radanović, O.,& Soković, M.. (2018). Design, synthesis and antimicrobial activity of usnic acid derivatives. in MedChemComm, 9(5), 870-882.
https://doi.org/10.1039/C8MD00076J

Kartsev V, Lichitsky B, Geronikaki A, Petrou A, Ivanov M, Kostić M, Radanović O, Soković M. Design, synthesis and antimicrobial activity of usnic acid derivatives. in MedChemComm. 2018;9(5):870-882.
doi:10.1039/C8MD00076J .

Kartsev, Victor, Lichitsky, Boris, Geronikaki, Athina, Petrou, Anthi, Ivanov, Marija, Kostić, Marina, Radanović, Oliver, Soković, Marina, "Design, synthesis and antimicrobial activity of usnic acid derivatives" in MedChemComm, 9, no. 5 (2018):870-882,
https://doi.org/10.1039/C8MD00076J . .

TY  - JOUR
AU  - Haroun, Michelyne
AU  - Tratrat, Christophe
AU  - Kositsi, Katerina
AU  - Tsolaki, Evangelia
AU  - Petrou, Anthi
AU  - Aldhubiab, Bandar
AU  - Attimarad, Mahesh
AU  - Harsha, Sree
AU  - Geronikaki, Athina
AU  - Venugopala, Katharigatta N.
AU  - Elsewedy, Heba S.
AU  - Soković, Marina
AU  - Glamočlija, Jasmina
AU  - Ćirić, Ana
PY  - 2018
UR  - http://www.eurekaselect.com/159582/article
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3071
AB  - BACKGROUND Thiazole and benzothiazole derivatives, as well as thiazolidinones are very important scaffolds in medicinal chemistry. Literature has revealed that they possess a wide spectrum of biological activities including antimicrobial activity. OBJECTIVE The goal of this paper is the designing of new benzothiazole based thiazolidinones and the evaluation of their biological activities. METHODS The designed compounds were synthesized using classical organic synthesis methods. The antimicrobial activity was evaluated using the method of microdilution. RESULTS The twelve newly synthesized compounds showed antimicrobial properties. All compounds appeared to be more active than ampicillin in most studied strains and in some cases, more active than streptomycin. Antifungal activity, in most cases was also better than the reference drugs ketoconazole and bifonazole. The prediction of cytotoxicity revealed that the synthesized compounds were not toxic (LD50 350-1000 mg/kg of body weight). Docking studies on the antibacterial activity confirmed the biological results. CONCLUSION The twelve new compounds were synthesized and studied for their antimicrobial activity. The compounds appeared to be promising antimicrobial agents and could be the lead compounds for new, more potent drugs. According to the docking prediction, the compounds could be MurB inhibitors.
T2  - Current Topics in Medicinal Chemistry
T1  - New Benzothiazole-based Thiazolidinones as Potent Antimicrobial Agents. Design, synthesis and Biological Evaluation.
IS  - 1
VL  - 18
DO  - 10.2174/1568026618666180206101814
SP  - 75
EP  - 87
ER  - 

@article{
author = "Haroun, Michelyne and Tratrat, Christophe and Kositsi, Katerina and Tsolaki, Evangelia and Petrou, Anthi and Aldhubiab, Bandar and Attimarad, Mahesh and Harsha, Sree and Geronikaki, Athina and Venugopala, Katharigatta N. and Elsewedy, Heba S. and Soković, Marina and Glamočlija, Jasmina and Ćirić, Ana",
year = "2018",
abstract = "BACKGROUND Thiazole and benzothiazole derivatives, as well as thiazolidinones are very important scaffolds in medicinal chemistry. Literature has revealed that they possess a wide spectrum of biological activities including antimicrobial activity. OBJECTIVE The goal of this paper is the designing of new benzothiazole based thiazolidinones and the evaluation of their biological activities. METHODS The designed compounds were synthesized using classical organic synthesis methods. The antimicrobial activity was evaluated using the method of microdilution. RESULTS The twelve newly synthesized compounds showed antimicrobial properties. All compounds appeared to be more active than ampicillin in most studied strains and in some cases, more active than streptomycin. Antifungal activity, in most cases was also better than the reference drugs ketoconazole and bifonazole. The prediction of cytotoxicity revealed that the synthesized compounds were not toxic (LD50 350-1000 mg/kg of body weight). Docking studies on the antibacterial activity confirmed the biological results. CONCLUSION The twelve new compounds were synthesized and studied for their antimicrobial activity. The compounds appeared to be promising antimicrobial agents and could be the lead compounds for new, more potent drugs. According to the docking prediction, the compounds could be MurB inhibitors.",
journal = "Current Topics in Medicinal Chemistry",
title = "New Benzothiazole-based Thiazolidinones as Potent Antimicrobial Agents. Design, synthesis and Biological Evaluation.",
number = "1",
volume = "18",
doi = "10.2174/1568026618666180206101814",
pages = "75-87"
}

Haroun, M., Tratrat, C., Kositsi, K., Tsolaki, E., Petrou, A., Aldhubiab, B., Attimarad, M., Harsha, S., Geronikaki, A., Venugopala, K. N., Elsewedy, H. S., Soković, M., Glamočlija, J.,& Ćirić, A.. (2018). New Benzothiazole-based Thiazolidinones as Potent Antimicrobial Agents. Design, synthesis and Biological Evaluation.. in Current Topics in Medicinal Chemistry, 18(1), 75-87.
https://doi.org/10.2174/1568026618666180206101814

Haroun M, Tratrat C, Kositsi K, Tsolaki E, Petrou A, Aldhubiab B, Attimarad M, Harsha S, Geronikaki A, Venugopala KN, Elsewedy HS, Soković M, Glamočlija J, Ćirić A. New Benzothiazole-based Thiazolidinones as Potent Antimicrobial Agents. Design, synthesis and Biological Evaluation.. in Current Topics in Medicinal Chemistry. 2018;18(1):75-87.
doi:10.2174/1568026618666180206101814 .

Haroun, Michelyne, Tratrat, Christophe, Kositsi, Katerina, Tsolaki, Evangelia, Petrou, Anthi, Aldhubiab, Bandar, Attimarad, Mahesh, Harsha, Sree, Geronikaki, Athina, Venugopala, Katharigatta N., Elsewedy, Heba S., Soković, Marina, Glamočlija, Jasmina, Ćirić, Ana, "New Benzothiazole-based Thiazolidinones as Potent Antimicrobial Agents. Design, synthesis and Biological Evaluation." in Current Topics in Medicinal Chemistry, 18, no. 1 (2018):75-87,
https://doi.org/10.2174/1568026618666180206101814 . .

TY  - JOUR
AU  - Incerti, Matteo
AU  - Vicini, Paola
AU  - Geronikaki, Athina
AU  - Eleftheriou, Phaedra
AU  - Tsagkadouras, Athanasios
AU  - Zoumpoulakis, Panagiotis
AU  - Fotakis, Charalmpos
AU  - Ćirić, Ana
AU  - Glamočlija, Jasmina
AU  - Soković, Marina
PY  - 2017
UR  - http://xlink.rsc.org/?DOI=C7MD00334J
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2926
AB  - A series of 21 novel N-[2-phenyl-4-oxo-1,3-thiazolidin-3-yl]-1,2-benzothiazole-3-carboxamides/acetamides (4a–4p) as well as a series of N′-(halophenylmethylidene)-1,2-benzothiazole-3-acetohydrazides (3h–3p) have been synthesized and evaluated for their antimicrobial activity against eight bacterial and eight fungal species, among them plant, animal and human pathogens and food contaminating species. All compounds appeared to be potent and the best activity was exhibited by compound 4d with MIC in the range of 10.7–21.4 μmol mL−1 × 10−2 and MBC of 21.4–40.2 μmol mL−1 × 10−2. The best antifungal activity was observed for compounds 4p and 3h. Elucidation of the relationship between the antimicrobial activity and molecular properties of the synthesized compounds was also performed. Synthetic intermediates were also tested with several exhibiting good antimicrobial activities. Docking studies for some compounds were performed.
T2  - MedChemComm
T2  - MedChemComm
T1  - New N -(2-phenyl-4-oxo-1,3-thiazolidin-3-yl)-1,2-benzothiazole-3-carboxamides and acetamides as antimicrobial agents
IS  - 11
VL  - 8
DO  - 10.1039/C7MD00334J
SP  - 2142
EP  - 2154
ER  - 

@article{
author = "Incerti, Matteo and Vicini, Paola and Geronikaki, Athina and Eleftheriou, Phaedra and Tsagkadouras, Athanasios and Zoumpoulakis, Panagiotis and Fotakis, Charalmpos and Ćirić, Ana and Glamočlija, Jasmina and Soković, Marina",
year = "2017",
abstract = "A series of 21 novel N-[2-phenyl-4-oxo-1,3-thiazolidin-3-yl]-1,2-benzothiazole-3-carboxamides/acetamides (4a–4p) as well as a series of N′-(halophenylmethylidene)-1,2-benzothiazole-3-acetohydrazides (3h–3p) have been synthesized and evaluated for their antimicrobial activity against eight bacterial and eight fungal species, among them plant, animal and human pathogens and food contaminating species. All compounds appeared to be potent and the best activity was exhibited by compound 4d with MIC in the range of 10.7–21.4 μmol mL−1 × 10−2 and MBC of 21.4–40.2 μmol mL−1 × 10−2. The best antifungal activity was observed for compounds 4p and 3h. Elucidation of the relationship between the antimicrobial activity and molecular properties of the synthesized compounds was also performed. Synthetic intermediates were also tested with several exhibiting good antimicrobial activities. Docking studies for some compounds were performed.",
journal = "MedChemComm, MedChemComm",
title = "New N -(2-phenyl-4-oxo-1,3-thiazolidin-3-yl)-1,2-benzothiazole-3-carboxamides and acetamides as antimicrobial agents",
number = "11",
volume = "8",
doi = "10.1039/C7MD00334J",
pages = "2142-2154"
}

Incerti, M., Vicini, P., Geronikaki, A., Eleftheriou, P., Tsagkadouras, A., Zoumpoulakis, P., Fotakis, C., Ćirić, A., Glamočlija, J.,& Soković, M.. (2017). New N -(2-phenyl-4-oxo-1,3-thiazolidin-3-yl)-1,2-benzothiazole-3-carboxamides and acetamides as antimicrobial agents. in MedChemComm, 8(11), 2142-2154.
https://doi.org/10.1039/C7MD00334J

Incerti M, Vicini P, Geronikaki A, Eleftheriou P, Tsagkadouras A, Zoumpoulakis P, Fotakis C, Ćirić A, Glamočlija J, Soković M. New N -(2-phenyl-4-oxo-1,3-thiazolidin-3-yl)-1,2-benzothiazole-3-carboxamides and acetamides as antimicrobial agents. in MedChemComm. 2017;8(11):2142-2154.
doi:10.1039/C7MD00334J .

Incerti, Matteo, Vicini, Paola, Geronikaki, Athina, Eleftheriou, Phaedra, Tsagkadouras, Athanasios, Zoumpoulakis, Panagiotis, Fotakis, Charalmpos, Ćirić, Ana, Glamočlija, Jasmina, Soković, Marina, "New N -(2-phenyl-4-oxo-1,3-thiazolidin-3-yl)-1,2-benzothiazole-3-carboxamides and acetamides as antimicrobial agents" in MedChemComm, 8, no. 11 (2017):2142-2154,
https://doi.org/10.1039/C7MD00334J . .

TY  - JOUR
AU  - Pitta, Eleni
AU  - Tsolaki, Evangelia
AU  - Geronikaki, Athina
AU  - Petrović, Jovana
AU  - Glamočlija, Jasmina
AU  - Soković, Marina
AU  - Crespan, Emmanuele
AU  - Maga, Giovanni
AU  - Bhunia, Shome S.
AU  - Saxena, Anil K.
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2088
AB  - As a part of our ongoing research in the development of new
   antimicrobials, herein, we report the synthesis of ten compounds which
   combine three bioactive moieties: thiazole, adamantane and
   4-thiazolidinone. Evaluation of their antibacterial activity revealed
   that the newly synthesized compounds exhibited remarkable growth
   inhibition of a wide spectrum of Gram-positive bacteria, Gram-negative
   bacteria and fungi. The majority of the compounds displayed greater
   antibacterial activity than the reference drugs (ampicillin and
   streptomycin), while the antifungal activity was significantly higher
   than that of the reference drugs bifonazole and ketoconazole.
   Additionally, the title compounds were screened for HIV-1 reverse
   transcriptase inhibitory activity, showing no significant activity.
   Moreover, docking studies were performed in order to explore possible
   binding modes at the MurB protein of S. aureus.
T2  - Medchemcomm
T1  - 4-Thiazolidinone derivatives as potent antimicrobial agents:
 microwave-assisted synthesis, biological evaluation and docking studies
IS  - 2
VL  - 6
DO  - 10.1039/c4md00399c
SP  - 319
EP  - 326
ER  - 

@article{
author = "Pitta, Eleni and Tsolaki, Evangelia and Geronikaki, Athina and Petrović, Jovana and Glamočlija, Jasmina and Soković, Marina and Crespan, Emmanuele and Maga, Giovanni and Bhunia, Shome S. and Saxena, Anil K.",
year = "2015",
abstract = "As a part of our ongoing research in the development of new
   antimicrobials, herein, we report the synthesis of ten compounds which
   combine three bioactive moieties: thiazole, adamantane and
   4-thiazolidinone. Evaluation of their antibacterial activity revealed
   that the newly synthesized compounds exhibited remarkable growth
   inhibition of a wide spectrum of Gram-positive bacteria, Gram-negative
   bacteria and fungi. The majority of the compounds displayed greater
   antibacterial activity than the reference drugs (ampicillin and
   streptomycin), while the antifungal activity was significantly higher
   than that of the reference drugs bifonazole and ketoconazole.
   Additionally, the title compounds were screened for HIV-1 reverse
   transcriptase inhibitory activity, showing no significant activity.
   Moreover, docking studies were performed in order to explore possible
   binding modes at the MurB protein of S. aureus.",
journal = "Medchemcomm",
title = "4-Thiazolidinone derivatives as potent antimicrobial agents:
 microwave-assisted synthesis, biological evaluation and docking studies",
number = "2",
volume = "6",
doi = "10.1039/c4md00399c",
pages = "319-326"
}

Pitta, E., Tsolaki, E., Geronikaki, A., Petrović, J., Glamočlija, J., Soković, M., Crespan, E., Maga, G., Bhunia, S. S.,& Saxena, A. K.. (2015). 4-Thiazolidinone derivatives as potent antimicrobial agents:
 microwave-assisted synthesis, biological evaluation and docking studies. in Medchemcomm, 6(2), 319-326.
https://doi.org/10.1039/c4md00399c

Pitta E, Tsolaki E, Geronikaki A, Petrović J, Glamočlija J, Soković M, Crespan E, Maga G, Bhunia SS, Saxena AK. 4-Thiazolidinone derivatives as potent antimicrobial agents:
 microwave-assisted synthesis, biological evaluation and docking studies. in Medchemcomm. 2015;6(2):319-326.
doi:10.1039/c4md00399c .

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