TY  - JOUR
AU  - Popov Aleksandrov, Aleksandra
AU  - Tucović, Dina
AU  - Kulaš, Jelena
AU  - Popović, Dušanka
AU  - Kataranovski, Dragan
AU  - Kataranovski, Milena
AU  - Mirkov, Ivana
PY  - 2024
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6507
AB  - The use of anticoagulant rodenticides (ARs) is one of the most commonly employed management methods for
pest rodents. ARs compete with vitamin K (VK) required for the synthesis of blood clotting factors in the liver,
resulting in inhibition of blood coagulation and often animal death due to hemorrhage. Besides rodents (target
species), ARs may affect non-target animal species and humans. Out of hemostasis disturbance, the effects of ARs
may be related to the inhibition of proteins that require VK for their synthesis but are not involved in the
coagulation process, to their direct cytotoxicity, and their pro-oxidant/proinflammatory activity. A survey of the
cellular and molecular mechanisms of these sublethal/asymptomatic AR effects is given in this review. Data from
field, clinical, and experimental studies are presented. Knowledge of these mechanisms might improve hazard
characterization and identification of potential ecotoxicological risks associated with ARs, contributing to a safer
use of these chemicals.
PB  - New York, NY : Elsevier Science
T2  - Comparative Biochemistry and Physiology, Part C
T1  - Toxicology of chemical biocides: Anticoagulant rodenticides – Beyond hemostasis disturbance
VL  - 277
DO  - 10.1016/j.cbpc.2024.109841
SP  - 109841
ER  - 

@article{
author = "Popov Aleksandrov, Aleksandra and Tucović, Dina and Kulaš, Jelena and Popović, Dušanka and Kataranovski, Dragan and Kataranovski, Milena and Mirkov, Ivana",
year = "2024",
abstract = "The use of anticoagulant rodenticides (ARs) is one of the most commonly employed management methods for
pest rodents. ARs compete with vitamin K (VK) required for the synthesis of blood clotting factors in the liver,
resulting in inhibition of blood coagulation and often animal death due to hemorrhage. Besides rodents (target
species), ARs may affect non-target animal species and humans. Out of hemostasis disturbance, the effects of ARs
may be related to the inhibition of proteins that require VK for their synthesis but are not involved in the
coagulation process, to their direct cytotoxicity, and their pro-oxidant/proinflammatory activity. A survey of the
cellular and molecular mechanisms of these sublethal/asymptomatic AR effects is given in this review. Data from
field, clinical, and experimental studies are presented. Knowledge of these mechanisms might improve hazard
characterization and identification of potential ecotoxicological risks associated with ARs, contributing to a safer
use of these chemicals.",
publisher = "New York, NY : Elsevier Science",
journal = "Comparative Biochemistry and Physiology, Part C",
title = "Toxicology of chemical biocides: Anticoagulant rodenticides – Beyond hemostasis disturbance",
volume = "277",
doi = "10.1016/j.cbpc.2024.109841",
pages = "109841"
}

Popov Aleksandrov, A., Tucović, D., Kulaš, J., Popović, D., Kataranovski, D., Kataranovski, M.,& Mirkov, I.. (2024). Toxicology of chemical biocides: Anticoagulant rodenticides – Beyond hemostasis disturbance. in Comparative Biochemistry and Physiology, Part C
New York, NY : Elsevier Science., 277, 109841.
https://doi.org/10.1016/j.cbpc.2024.109841

Popov Aleksandrov A, Tucović D, Kulaš J, Popović D, Kataranovski D, Kataranovski M, Mirkov I. Toxicology of chemical biocides: Anticoagulant rodenticides – Beyond hemostasis disturbance. in Comparative Biochemistry and Physiology, Part C. 2024;277:109841.
doi:10.1016/j.cbpc.2024.109841 .

Popov Aleksandrov, Aleksandra, Tucović, Dina, Kulaš, Jelena, Popović, Dušanka, Kataranovski, Dragan, Kataranovski, Milena, Mirkov, Ivana, "Toxicology of chemical biocides: Anticoagulant rodenticides – Beyond hemostasis disturbance" in Comparative Biochemistry and Physiology, Part C, 277 (2024):109841,
https://doi.org/10.1016/j.cbpc.2024.109841 . .

TY  - JOUR
AU  - Mirkov, Ivana
AU  - Tucović, Dina
AU  - Kulaš, Jelena
AU  - Malešević, Anastasija
AU  - Kataranovski, Dragan
AU  - Kataranovski, Milena
AU  - Popov Aleksandrov, Aleksandra
PY  - 2023
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6305
AB  - The importance of issues associated with urban/commensal rats and mice (property damage, management costs,
and health risks) press upon research on these animals. While the demography of commensal rodents is mostly
studied, the need for understanding factors influencing their natural morbidity/mortality is also stressed. In this
respect, more attention is expected to be paid to immunity, the physiological mechanism of defense against host
survival threats (pathogens, parasites, diseases). Commensal rats and mice carry numerous pathogens that evoke
diverse immune responses. The state of immunity in commensal house mice is studied in great detail, owing to
the use of laboratory strains in biomedical research. Because commensal rats are, compared to mice, carriers
of more zoonotic agents, rats’ immunity is studied mainly in that context. Some of these zoonotic agents cause
chronic, asymptomatic infections, which justified studies of immunological mechanisms of pathogen tolerance
versus clearance regulation in rats. Occurrence of some infections in specific tissues/organs pressed upon analysis
of local/regional immune responses and/or immunopathology. A survey of immunological activity/responses in
commensal rats is given in this review, with mention of existing data in commensal mice. It should throw some
light on the factors relevant to their morbidity and lifespan, supplementing the knowledge of commensal rodent
ecology.
PB  - John Wiley and Sons
T2  - Integrative Zoology
T1  - Physiological strategies in wild rodents: immune defenses of commensal rats
DO  - 10.1111/1749-4877.12766
SP  - 1
EP  - 21
ER  - 

@article{
author = "Mirkov, Ivana and Tucović, Dina and Kulaš, Jelena and Malešević, Anastasija and Kataranovski, Dragan and Kataranovski, Milena and Popov Aleksandrov, Aleksandra",
year = "2023",
abstract = "The importance of issues associated with urban/commensal rats and mice (property damage, management costs,
and health risks) press upon research on these animals. While the demography of commensal rodents is mostly
studied, the need for understanding factors influencing their natural morbidity/mortality is also stressed. In this
respect, more attention is expected to be paid to immunity, the physiological mechanism of defense against host
survival threats (pathogens, parasites, diseases). Commensal rats and mice carry numerous pathogens that evoke
diverse immune responses. The state of immunity in commensal house mice is studied in great detail, owing to
the use of laboratory strains in biomedical research. Because commensal rats are, compared to mice, carriers
of more zoonotic agents, rats’ immunity is studied mainly in that context. Some of these zoonotic agents cause
chronic, asymptomatic infections, which justified studies of immunological mechanisms of pathogen tolerance
versus clearance regulation in rats. Occurrence of some infections in specific tissues/organs pressed upon analysis
of local/regional immune responses and/or immunopathology. A survey of immunological activity/responses in
commensal rats is given in this review, with mention of existing data in commensal mice. It should throw some
light on the factors relevant to their morbidity and lifespan, supplementing the knowledge of commensal rodent
ecology.",
publisher = "John Wiley and Sons",
journal = "Integrative Zoology",
title = "Physiological strategies in wild rodents: immune defenses of commensal rats",
doi = "10.1111/1749-4877.12766",
pages = "1-21"
}

Mirkov, I., Tucović, D., Kulaš, J., Malešević, A., Kataranovski, D., Kataranovski, M.,& Popov Aleksandrov, A.. (2023). Physiological strategies in wild rodents: immune defenses of commensal rats. in Integrative Zoology
John Wiley and Sons., 1-21.
https://doi.org/10.1111/1749-4877.12766

Mirkov I, Tucović D, Kulaš J, Malešević A, Kataranovski D, Kataranovski M, Popov Aleksandrov A. Physiological strategies in wild rodents: immune defenses of commensal rats. in Integrative Zoology. 2023;:1-21.
doi:10.1111/1749-4877.12766 .

Mirkov, Ivana, Tucović, Dina, Kulaš, Jelena, Malešević, Anastasija, Kataranovski, Dragan, Kataranovski, Milena, Popov Aleksandrov, Aleksandra, "Physiological strategies in wild rodents: immune defenses of commensal rats" in Integrative Zoology (2023):1-21,
https://doi.org/10.1111/1749-4877.12766 . .

TY  - JOUR
AU  - Tucović, Dina
AU  - Kulaš, Jelena
AU  - Mirkov, Ivana
AU  - Popović, Dušanka
AU  - Zolotarevski, Lidija
AU  - Despotović, Marta
AU  - Kataranovski, Milena
AU  - Popov Aleksandrov, Aleksandra
PY  - 2022
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5301
AB  - Objective The effect of oral cadmium (Cd) intake to influence contact skin allergies was examined,
since it is known that Cd is a heavy metal that affects many tissues, including the skin, in which it
disturbs homeostasis, thus resulting in inflammation and injury.
Methods Male rats were evoked with experimental contact hypersensitivity reaction (CHS) to hapten
dinitrochlorobenzene (DNCB), after prolonged (30 day) oral exposure to an environmentally relevant Cd
dose (5 ppm). The ear cell population was analyzed with flow cytometry. Cytokine production by ear
skin cells and the activity of skin-draining lymph node (DLN) cells were measured using enzyme-linked
immunosorbent assay (ELISA).
Results Orally acquired Cd (5 ppm) increased CHS intensity only in Dark Agouti (DA) rats by affecting
inflammatory responses in both the sensitization (an increase of IFN-γ and IL-17 cytokine production)
and challenge (an increase of CD8+ and CD4+ cell number and TNF, IFN-γ and IL-17 cytokine production)
phases. An increased CHS reaction was seen in Albino Oxford (AO) rats only at a high Cd dose (50 ppm),
during the challenge phase (an increase of CD8+ and CD4+ cell number and TNF, IFN-γ and IL-17 cytokine
production).
Conclusion These novel data indicate that oral Cd intensifies the skin response to sensitizing chemicals
such as DNCB.
PB  - Beijing: Chinese Center for Disease Control and Prevention
T2  - Biomedical and Environmental Sciences
T1  - Oral Cadmium Intake Enhances Contact Allergen-induced Skin Reaction in Rats
IS  - 11
VL  - 35
DO  - 10.3967/bes2022.132
SP  - 1038
EP  - 1050
ER  - 

@article{
author = "Tucović, Dina and Kulaš, Jelena and Mirkov, Ivana and Popović, Dušanka and Zolotarevski, Lidija and Despotović, Marta and Kataranovski, Milena and Popov Aleksandrov, Aleksandra",
year = "2022",
abstract = "Objective The effect of oral cadmium (Cd) intake to influence contact skin allergies was examined,
since it is known that Cd is a heavy metal that affects many tissues, including the skin, in which it
disturbs homeostasis, thus resulting in inflammation and injury.
Methods Male rats were evoked with experimental contact hypersensitivity reaction (CHS) to hapten
dinitrochlorobenzene (DNCB), after prolonged (30 day) oral exposure to an environmentally relevant Cd
dose (5 ppm). The ear cell population was analyzed with flow cytometry. Cytokine production by ear
skin cells and the activity of skin-draining lymph node (DLN) cells were measured using enzyme-linked
immunosorbent assay (ELISA).
Results Orally acquired Cd (5 ppm) increased CHS intensity only in Dark Agouti (DA) rats by affecting
inflammatory responses in both the sensitization (an increase of IFN-γ and IL-17 cytokine production)
and challenge (an increase of CD8+ and CD4+ cell number and TNF, IFN-γ and IL-17 cytokine production)
phases. An increased CHS reaction was seen in Albino Oxford (AO) rats only at a high Cd dose (50 ppm),
during the challenge phase (an increase of CD8+ and CD4+ cell number and TNF, IFN-γ and IL-17 cytokine
production).
Conclusion These novel data indicate that oral Cd intensifies the skin response to sensitizing chemicals
such as DNCB.",
publisher = "Beijing: Chinese Center for Disease Control and Prevention",
journal = "Biomedical and Environmental Sciences",
title = "Oral Cadmium Intake Enhances Contact Allergen-induced Skin Reaction in Rats",
number = "11",
volume = "35",
doi = "10.3967/bes2022.132",
pages = "1038-1050"
}

Tucović, D., Kulaš, J., Mirkov, I., Popović, D., Zolotarevski, L., Despotović, M., Kataranovski, M.,& Popov Aleksandrov, A.. (2022). Oral Cadmium Intake Enhances Contact Allergen-induced Skin Reaction in Rats. in Biomedical and Environmental Sciences
Beijing: Chinese Center for Disease Control and Prevention., 35(11), 1038-1050.
https://doi.org/10.3967/bes2022.132

Tucović D, Kulaš J, Mirkov I, Popović D, Zolotarevski L, Despotović M, Kataranovski M, Popov Aleksandrov A. Oral Cadmium Intake Enhances Contact Allergen-induced Skin Reaction in Rats. in Biomedical and Environmental Sciences. 2022;35(11):1038-1050.
doi:10.3967/bes2022.132 .

Tucović, Dina, Kulaš, Jelena, Mirkov, Ivana, Popović, Dušanka, Zolotarevski, Lidija, Despotović, Marta, Kataranovski, Milena, Popov Aleksandrov, Aleksandra, "Oral Cadmium Intake Enhances Contact Allergen-induced Skin Reaction in Rats" in Biomedical and Environmental Sciences, 35, no. 11 (2022):1038-1050,
https://doi.org/10.3967/bes2022.132 . .

TY  - CONF
AU  - Popov Aleksandrov, Aleksandra
AU  - Mirkov, Ivana
AU  - Tucović, Dina
AU  - Kulaš, Jelena
AU  - Ninkov, Marina
AU  - Popović, Dušanka
AU  - Malešević, Anastasija
AU  - Kataranovski, Milena
PY  - 2022
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5141
AB  - Имунски систем је осетљива мета токсичног деловања загађивача из спољашње средине. Интеракција загађивача са ћелијама имунског система може довести до поремећаја имунолошки-посредоване ткивне хомеостазе са штетним здравственим ефектима. Тешки метали спадају у најопасније загађиваче међу којима је кадмијум (Cd) један од најтоксичнијих, с обзиром на податке који показују да је токсичан при ниским концентрацијама и на студије које га повезују са имунолошки-посредованим поремећајима. Кадмијум најчешће доспева у организам оралним путем, уношењем контаминиране хране и воде, након чега се путем крви дистрибуира до свих органа где се депонује. На пацовском моделу продужене оралне примене Cd (дозе релевантне за срединску изложеност) показали смо да Cd остварује имуномодулаторне ефекте локално (у цревном тракту) али и у удаљеним ткивима плућа и коже. Оштећење ткива и инфламација (повећан оксидативни стрес и продукција проинфламаторних цитокина) запажени су у сва три органа. Поремећај имунске хомеостазе у цревима огледа се и у стимулацији ефекторског имунског одговора (пролиферација, IFN-γ, IL-17) у чворовима који дренирају ову регију. Инфламација у кожи и повећана оксидативна и проинфламаторна активност епидермних ћелија коинцидирају са повећаном реактивношћу овог ткива на контактни алерген. Утичући на активност имунског система орално примењен Cd може да мења његову функцију и последично осетљивост на развој болести, што указује да Cd може представљати озбиљну претњу по здравље људи.
AB  - Имунски систем је осетљива мета токсичног деловања загађивача из спољашње средине. Интеракција загађивача са ћелијама имунског система може довести до поремећаја имунолошки-посредоване ткивне хомеостазе са штетним здравственим ефектима. Тешки метали спадају у најопасније загађиваче међу којима је кадмијум (Cd) један од најтоксичнијих, с обзиром на податке који показују да је токсичан при ниским концентрацијама и на студије које га повезују са имунолошки-посредованим поремећајима. Кадмијум најчешће доспева у организам оралним путем, уношењем контаминиране хране и воде, након чега се путем крви дистрибуира до свих органа где се депонује. На пацовском моделу продужене оралне примене Cd (дозе релевантне за срединску изложеност) показали смо да Cd остварује имуномодулаторне ефекте локално (у цревном тракту) али и у удаљеним ткивима плућа и коже. Оштећење ткива и инфламација (повећан оксидативни стрес и продукција проинфламаторних цитокина) запажени су у сва три органа. Поремећај имунске хомеостазе у цревима огледа се и у стимулацији ефекторског имунског одговора (пролиферација, IFN-γ, IL-17) у чворовима који дренирају ову регију. Инфламација у кожи и повећана оксидативна и проинфламаторна активност епидермних ћелија коинцидирају са повећаном реактивношћу овог ткива на контактни алерген. Утичући на активност имунског система орално примењен Cd може да мења његову функцију и последично осетљивост на развој болести, што указује да Cd може представљати озбиљну претњу по здравље људи.
PB  - Belgrade: Serbian Biological Society
C3  - Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia
T1  - Imunomodulatorni efekti zagađivača iz spoljašnje sredine:primer teškog metala kadmijuma
T1  - Имуномодулаторни ефекти загађивача из спољашње средине:пример тешког метала кадмијума
SP  - 114
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5141
ER  - 

@conference{
author = "Popov Aleksandrov, Aleksandra and Mirkov, Ivana and Tucović, Dina and Kulaš, Jelena and Ninkov, Marina and Popović, Dušanka and Malešević, Anastasija and Kataranovski, Milena",
year = "2022",
abstract = "Имунски систем је осетљива мета токсичног деловања загађивача из спољашње средине. Интеракција загађивача са ћелијама имунског система може довести до поремећаја имунолошки-посредоване ткивне хомеостазе са штетним здравственим ефектима. Тешки метали спадају у најопасније загађиваче међу којима је кадмијум (Cd) један од најтоксичнијих, с обзиром на податке који показују да је токсичан при ниским концентрацијама и на студије које га повезују са имунолошки-посредованим поремећајима. Кадмијум најчешће доспева у организам оралним путем, уношењем контаминиране хране и воде, након чега се путем крви дистрибуира до свих органа где се депонује. На пацовском моделу продужене оралне примене Cd (дозе релевантне за срединску изложеност) показали смо да Cd остварује имуномодулаторне ефекте локално (у цревном тракту) али и у удаљеним ткивима плућа и коже. Оштећење ткива и инфламација (повећан оксидативни стрес и продукција проинфламаторних цитокина) запажени су у сва три органа. Поремећај имунске хомеостазе у цревима огледа се и у стимулацији ефекторског имунског одговора (пролиферација, IFN-γ, IL-17) у чворовима који дренирају ову регију. Инфламација у кожи и повећана оксидативна и проинфламаторна активност епидермних ћелија коинцидирају са повећаном реактивношћу овог ткива на контактни алерген. Утичући на активност имунског система орално примењен Cd може да мења његову функцију и последично осетљивост на развој болести, што указује да Cd може представљати озбиљну претњу по здравље људи., Имунски систем је осетљива мета токсичног деловања загађивача из спољашње средине. Интеракција загађивача са ћелијама имунског система може довести до поремећаја имунолошки-посредоване ткивне хомеостазе са штетним здравственим ефектима. Тешки метали спадају у најопасније загађиваче међу којима је кадмијум (Cd) један од најтоксичнијих, с обзиром на податке који показују да је токсичан при ниским концентрацијама и на студије које га повезују са имунолошки-посредованим поремећајима. Кадмијум најчешће доспева у организам оралним путем, уношењем контаминиране хране и воде, након чега се путем крви дистрибуира до свих органа где се депонује. На пацовском моделу продужене оралне примене Cd (дозе релевантне за срединску изложеност) показали смо да Cd остварује имуномодулаторне ефекте локално (у цревном тракту) али и у удаљеним ткивима плућа и коже. Оштећење ткива и инфламација (повећан оксидативни стрес и продукција проинфламаторних цитокина) запажени су у сва три органа. Поремећај имунске хомеостазе у цревима огледа се и у стимулацији ефекторског имунског одговора (пролиферација, IFN-γ, IL-17) у чворовима који дренирају ову регију. Инфламација у кожи и повећана оксидативна и проинфламаторна активност епидермних ћелија коинцидирају са повећаном реактивношћу овог ткива на контактни алерген. Утичући на активност имунског система орално примењен Cd може да мења његову функцију и последично осетљивост на развој болести, што указује да Cd може представљати озбиљну претњу по здравље људи.",
publisher = "Belgrade: Serbian Biological Society",
journal = "Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia",
title = "Imunomodulatorni efekti zagađivača iz spoljašnje sredine:primer teškog metala kadmijuma, Имуномодулаторни ефекти загађивача из спољашње средине:пример тешког метала кадмијума",
pages = "114",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5141"
}

Popov Aleksandrov, A., Mirkov, I., Tucović, D., Kulaš, J., Ninkov, M., Popović, D., Malešević, A.,& Kataranovski, M.. (2022). Imunomodulatorni efekti zagađivača iz spoljašnje sredine:primer teškog metala kadmijuma. in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia
Belgrade: Serbian Biological Society., 114.
https://hdl.handle.net/21.15107/rcub_ibiss_5141

Popov Aleksandrov A, Mirkov I, Tucović D, Kulaš J, Ninkov M, Popović D, Malešević A, Kataranovski M. Imunomodulatorni efekti zagađivača iz spoljašnje sredine:primer teškog metala kadmijuma. in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia. 2022;:114.
https://hdl.handle.net/21.15107/rcub_ibiss_5141 .

Popov Aleksandrov, Aleksandra, Mirkov, Ivana, Tucović, Dina, Kulaš, Jelena, Ninkov, Marina, Popović, Dušanka, Malešević, Anastasija, Kataranovski, Milena, "Imunomodulatorni efekti zagađivača iz spoljašnje sredine:primer teškog metala kadmijuma" in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia (2022):114,
https://hdl.handle.net/21.15107/rcub_ibiss_5141 .

TY  - CONF
AU  - Mirkov, Ivana
AU  - Popov Aleksandrov, Aleksandra
AU  - Tucović, Dina
AU  - Kulaš, Jelena
AU  - Popović, Dušanka
AU  - Malešević, Anastasija
AU  - Kataranovski, Milena
PY  - 2022
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5142
AB  - In addition to physical and chemical insults originating from nature (heavy metals, radiation, electromagnetic field), human beings are exposed to various agents as a result of progress in industry and technology (noise, pesticides, pharmaceuticals, personal care products, food additives, etc.) whose number continuously increases. Some of these agents may have adverse effects on the environment and human health and therefore every new product must be examined for its toxic potential and health risk. The immune system is an important homeostatic system that is included in response to various pathogens, but in other processes as well including wound healing and elimination of damaged cells and tumors. Due to its involvement in various physiological processes, alternation in immune system activity, as a consequence of exposure to xenobiotics, may cause an increase in the incidence of infections, tumors, allergies, and autoimmune diseases. Various tests that exist for the evaluation of immunotoxicity are grouped in two separate sets, tier one (experiments directed to measure the effect of xenobiotics on general immune parameters i.e. basic morphological and functional tests) and tier two(experiments aimed to more specifically define the cellular and biochemical mechanisms of toxicity). Evaluation of potential adverse effects of xenobiotics on the immune system is now incorporated into standard hazard identification and has improved human health risk assessment.
AB  - Pored fizičkih i hemijskih agenasa poreklom iz prirode (teški metali, zračenje, elektromagnetno polje), ljudska bića su izložena raznim agensima kao rezultat napretka industrije i tehnologije (buka, pesticidi, farmaceutski proizvodi, proizvodi za ličnu negu, aditivi u hrani, itd.) čiji se broj kontinuirano povećava. Neki od ovih agenasa mogu imati štetne efekte na životnu sredinu i zdravlje ljudi i stoga za svaki novi proizvod mora biti ispitan njegov toksični potencijal i rizik po zdravlje. Imunski sistem je važan homeostatski sistem koji je uključen u odgovor na različite patogene, ali i u druge procese kao što su zarastanje rana, eliminaciju oštećenih ćelija i tumora. Zbog uključenosti u različite fiziološke procese, promenjena aktivnost imunskog sistema, kao posledica izloženosti ksenobioticima, može dovesti do povećanja učestalosti infekcija, tumora, alergija i autoimunskih bolesti. Postoje različiti testovi za procenu imunotoksičnosti koji su grupisani u dva odvojena seta, prvi nivo (eksperimenti usmereni na merenje uticaja ksenobiotika na opšte imunološke parametre, tj. osnovni morfološki i funkcionalni testovi) i nivo dva (eksperimenti koji imaju za cilj da preciznije definišu ćelijske i biohemijske mehanizme toksičnosti). Procena potencijalnih štetnih efekata ksenobiotika na imunski sistem je sada uključena u standardnu identifikaciju opasnosti i poboljšala je procenu rizika koju ksenobiotici mogu imati po zdravlje ljudi.
PB  - Belgrade: Serbian Society of Corrosion and Materials Protection
C3  - Proceedings: Meeting point of the science and practice in the fields of corrosion, materials and environmental protection: XXIII YuCorr International Conference; 2022 May 16-19; Divčibare, Serbia
T1  - Immune System as a Target of Xenobiotics Toxicity
T1  - Imunski sistem kao meta toksičnog delovanja ksenobiotika
SP  - 7
EP  - 13
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5142
ER  - 

@conference{
author = "Mirkov, Ivana and Popov Aleksandrov, Aleksandra and Tucović, Dina and Kulaš, Jelena and Popović, Dušanka and Malešević, Anastasija and Kataranovski, Milena",
year = "2022",
abstract = "In addition to physical and chemical insults originating from nature (heavy metals, radiation, electromagnetic field), human beings are exposed to various agents as a result of progress in industry and technology (noise, pesticides, pharmaceuticals, personal care products, food additives, etc.) whose number continuously increases. Some of these agents may have adverse effects on the environment and human health and therefore every new product must be examined for its toxic potential and health risk. The immune system is an important homeostatic system that is included in response to various pathogens, but in other processes as well including wound healing and elimination of damaged cells and tumors. Due to its involvement in various physiological processes, alternation in immune system activity, as a consequence of exposure to xenobiotics, may cause an increase in the incidence of infections, tumors, allergies, and autoimmune diseases. Various tests that exist for the evaluation of immunotoxicity are grouped in two separate sets, tier one (experiments directed to measure the effect of xenobiotics on general immune parameters i.e. basic morphological and functional tests) and tier two(experiments aimed to more specifically define the cellular and biochemical mechanisms of toxicity). Evaluation of potential adverse effects of xenobiotics on the immune system is now incorporated into standard hazard identification and has improved human health risk assessment., Pored fizičkih i hemijskih agenasa poreklom iz prirode (teški metali, zračenje, elektromagnetno polje), ljudska bića su izložena raznim agensima kao rezultat napretka industrije i tehnologije (buka, pesticidi, farmaceutski proizvodi, proizvodi za ličnu negu, aditivi u hrani, itd.) čiji se broj kontinuirano povećava. Neki od ovih agenasa mogu imati štetne efekte na životnu sredinu i zdravlje ljudi i stoga za svaki novi proizvod mora biti ispitan njegov toksični potencijal i rizik po zdravlje. Imunski sistem je važan homeostatski sistem koji je uključen u odgovor na različite patogene, ali i u druge procese kao što su zarastanje rana, eliminaciju oštećenih ćelija i tumora. Zbog uključenosti u različite fiziološke procese, promenjena aktivnost imunskog sistema, kao posledica izloženosti ksenobioticima, može dovesti do povećanja učestalosti infekcija, tumora, alergija i autoimunskih bolesti. Postoje različiti testovi za procenu imunotoksičnosti koji su grupisani u dva odvojena seta, prvi nivo (eksperimenti usmereni na merenje uticaja ksenobiotika na opšte imunološke parametre, tj. osnovni morfološki i funkcionalni testovi) i nivo dva (eksperimenti koji imaju za cilj da preciznije definišu ćelijske i biohemijske mehanizme toksičnosti). Procena potencijalnih štetnih efekata ksenobiotika na imunski sistem je sada uključena u standardnu identifikaciju opasnosti i poboljšala je procenu rizika koju ksenobiotici mogu imati po zdravlje ljudi.",
publisher = "Belgrade: Serbian Society of Corrosion and Materials Protection",
journal = "Proceedings: Meeting point of the science and practice in the fields of corrosion, materials and environmental protection: XXIII YuCorr International Conference; 2022 May 16-19; Divčibare, Serbia",
title = "Immune System as a Target of Xenobiotics Toxicity, Imunski sistem kao meta toksičnog delovanja ksenobiotika",
pages = "7-13",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5142"
}

Mirkov, I., Popov Aleksandrov, A., Tucović, D., Kulaš, J., Popović, D., Malešević, A.,& Kataranovski, M.. (2022). Immune System as a Target of Xenobiotics Toxicity. in Proceedings: Meeting point of the science and practice in the fields of corrosion, materials and environmental protection: XXIII YuCorr International Conference; 2022 May 16-19; Divčibare, Serbia
Belgrade: Serbian Society of Corrosion and Materials Protection., 7-13.
https://hdl.handle.net/21.15107/rcub_ibiss_5142

Mirkov I, Popov Aleksandrov A, Tucović D, Kulaš J, Popović D, Malešević A, Kataranovski M. Immune System as a Target of Xenobiotics Toxicity. in Proceedings: Meeting point of the science and practice in the fields of corrosion, materials and environmental protection: XXIII YuCorr International Conference; 2022 May 16-19; Divčibare, Serbia. 2022;:7-13.
https://hdl.handle.net/21.15107/rcub_ibiss_5142 .

Mirkov, Ivana, Popov Aleksandrov, Aleksandra, Tucović, Dina, Kulaš, Jelena, Popović, Dušanka, Malešević, Anastasija, Kataranovski, Milena, "Immune System as a Target of Xenobiotics Toxicity" in Proceedings: Meeting point of the science and practice in the fields of corrosion, materials and environmental protection: XXIII YuCorr International Conference; 2022 May 16-19; Divčibare, Serbia (2022):7-13,
https://hdl.handle.net/21.15107/rcub_ibiss_5142 .

TY  - BOOK
AU  - Kataranovski, Dragan
AU  - Kataranovski, Milena
PY  - 2021
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/4781
AB  - Problematika predstavljena u ovoj publikaciji je podeljena u nekoliko celina. U prvoj celini dati su poreklo i evolucija, sistematika i opšte odlike sisara (Mammalia), posebno glodara (Rodentia), kratak prikaz faune glodara Srbije i njihova taksonomska pripadnost, bez obimnijeg prikaza bionomije pojedinih predstavnika. Posebno je dat je pregled vrsta glodara zdravstveno i ekonomski značajnih za čoveka uključujući pripadnike porodica Muridae (mišoliki glodari), Gliridae (puhovi), Cricetidae (hrčkovi) i Sciuridae (veverice), Uz svaki prikazani takson dati su relevantni podaci o njihovoj biologiji i ekologiji, sa ukazivanjem na stepen zaštićenosti pojedinih vrsta. Druga celina obrađuje epizootiološko-epidemiološki značaj glodara sa pregledom značajnijih virusnih i bakterijskih zoonoza, zoonoza izazvanih protozoama, zatim infekcija glodara saprofitnim i keratinofilnim gljivama, endoparazitskim eumetazoama (cestodama, trematodama i nematodama) i ektoparazitima, i razmatranjem faktora koji utiču na njihovu transmisiju. Treća celina se odnosi na ekonomski značaj glodara i prikazuje gubitke/štete koje glodari nanose ljudima i pojedinim životinjskim i biljnim vrstama, metode i modele za procenu štete. Četvrta celina je najobimnija i u njoj su prikazane metode za procenu brojnosti i gustine populacija mišolikih glodara, a zatim metode borbe protiv po čoveka štetnih glodara u cilju kontrole njihovih populacija. Dat je prikaz mera za kontrolu glodara koje obuhvataju 1. preventivne mere (agrotehničke, tehnološko-manipulativne, sanitarno-higijenske i građevinsko-tehničke mere, ultrazvučne i elektromagnetne talase i repelente) i 2. direktne mere (mehaničko-fizičke mere, biološke mere kontrole, genetičke metode, hemijske metode). Dat je detaljan spisak akutnih i hroničnih pesticida za glodare i fumiganata, sa mehanizmima delovanja. Osim prikaza efektivnosti, ukazano je i na ograničenja u vezi sa ovim agensima, uključujući mehanizme razvoja rezistencije na neke od hroničnih rodenticida. Posebno je obrađen uticaj rodenticida na živi svet (vrste koje nisu ciljne) uključujući toksičnost za organizme u vodenoj sredini, ptice i druge divlje životinje sa naglaskom na uticaj antikoagulantnih rodenticida na populacionu dinamiku i biodiverzitet glodara i drugih životinjskih vrsta. Dužna pažnja je posvećena toksičnosti za domaće životinje i čoveka. U vezi sa tim dati su i pristupi u ispitivanju rizika od izloženosti vrsta koje nisu cilj delovanja rodenticida. Peta celina obrađuje sprovođenje deratizacije počevši od pripreme i primene rodenticida do načina sprovođenja mera, uz opis mera zaštite pri izvođenju postupaka deratizacije i kontrole uspešnosti izvedene deratizacije.

Recenzenti publikacije su: Dr Ivo R. Savić, redovni profesor, Biološki fakultet Univerziteta u Beogradu, u penziji; Dr Srđan Stamenković, docent, Biološki fakultet Univerziteta u Beogradu; Dr Snežana Tomanović, naučni savetnik, Institut za medicinska istraživanja Univerziteta u Beogradu; Dr Vitomir Ćupić, redovni profesor, Fakultet veterinarske medicine Univerziteta u Beogradu. Sa Instituta za biološka istraživanja „Siniša Stanković“ – Instituta od nacionalnog značaja za Republiku Srbiju Univerziteta u Beogradu, Dr Ivana Mirkov, naučni savetnik; Dr Vanja Bugarski-Stanojević, viši naučni saradnik; Dr Vida Jojić, viši naučni saradnik; Dr Nada Ćosić, naučni saradnik.
PB  - Beograd: NNK Internacional
PB  - Beograd: Institut za biološka istraživanja "Siniša Stanković"
T1  - Štetni glodari: biologija, epizootiologija, ekologija i kontrola brojnosti
SP  - 1
EP  - 1058
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_4781
ER  - 

@book{
author = "Kataranovski, Dragan and Kataranovski, Milena",
year = "2021",
abstract = "Problematika predstavljena u ovoj publikaciji je podeljena u nekoliko celina. U prvoj celini dati su poreklo i evolucija, sistematika i opšte odlike sisara (Mammalia), posebno glodara (Rodentia), kratak prikaz faune glodara Srbije i njihova taksonomska pripadnost, bez obimnijeg prikaza bionomije pojedinih predstavnika. Posebno je dat je pregled vrsta glodara zdravstveno i ekonomski značajnih za čoveka uključujući pripadnike porodica Muridae (mišoliki glodari), Gliridae (puhovi), Cricetidae (hrčkovi) i Sciuridae (veverice), Uz svaki prikazani takson dati su relevantni podaci o njihovoj biologiji i ekologiji, sa ukazivanjem na stepen zaštićenosti pojedinih vrsta. Druga celina obrađuje epizootiološko-epidemiološki značaj glodara sa pregledom značajnijih virusnih i bakterijskih zoonoza, zoonoza izazvanih protozoama, zatim infekcija glodara saprofitnim i keratinofilnim gljivama, endoparazitskim eumetazoama (cestodama, trematodama i nematodama) i ektoparazitima, i razmatranjem faktora koji utiču na njihovu transmisiju. Treća celina se odnosi na ekonomski značaj glodara i prikazuje gubitke/štete koje glodari nanose ljudima i pojedinim životinjskim i biljnim vrstama, metode i modele za procenu štete. Četvrta celina je najobimnija i u njoj su prikazane metode za procenu brojnosti i gustine populacija mišolikih glodara, a zatim metode borbe protiv po čoveka štetnih glodara u cilju kontrole njihovih populacija. Dat je prikaz mera za kontrolu glodara koje obuhvataju 1. preventivne mere (agrotehničke, tehnološko-manipulativne, sanitarno-higijenske i građevinsko-tehničke mere, ultrazvučne i elektromagnetne talase i repelente) i 2. direktne mere (mehaničko-fizičke mere, biološke mere kontrole, genetičke metode, hemijske metode). Dat je detaljan spisak akutnih i hroničnih pesticida za glodare i fumiganata, sa mehanizmima delovanja. Osim prikaza efektivnosti, ukazano je i na ograničenja u vezi sa ovim agensima, uključujući mehanizme razvoja rezistencije na neke od hroničnih rodenticida. Posebno je obrađen uticaj rodenticida na živi svet (vrste koje nisu ciljne) uključujući toksičnost za organizme u vodenoj sredini, ptice i druge divlje životinje sa naglaskom na uticaj antikoagulantnih rodenticida na populacionu dinamiku i biodiverzitet glodara i drugih životinjskih vrsta. Dužna pažnja je posvećena toksičnosti za domaće životinje i čoveka. U vezi sa tim dati su i pristupi u ispitivanju rizika od izloženosti vrsta koje nisu cilj delovanja rodenticida. Peta celina obrađuje sprovođenje deratizacije počevši od pripreme i primene rodenticida do načina sprovođenja mera, uz opis mera zaštite pri izvođenju postupaka deratizacije i kontrole uspešnosti izvedene deratizacije.

Recenzenti publikacije su: Dr Ivo R. Savić, redovni profesor, Biološki fakultet Univerziteta u Beogradu, u penziji; Dr Srđan Stamenković, docent, Biološki fakultet Univerziteta u Beogradu; Dr Snežana Tomanović, naučni savetnik, Institut za medicinska istraživanja Univerziteta u Beogradu; Dr Vitomir Ćupić, redovni profesor, Fakultet veterinarske medicine Univerziteta u Beogradu. Sa Instituta za biološka istraživanja „Siniša Stanković“ – Instituta od nacionalnog značaja za Republiku Srbiju Univerziteta u Beogradu, Dr Ivana Mirkov, naučni savetnik; Dr Vanja Bugarski-Stanojević, viši naučni saradnik; Dr Vida Jojić, viši naučni saradnik; Dr Nada Ćosić, naučni saradnik.",
publisher = "Beograd: NNK Internacional, Beograd: Institut za biološka istraživanja "Siniša Stanković"",
title = "Štetni glodari: biologija, epizootiologija, ekologija i kontrola brojnosti",
pages = "1-1058",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_4781"
}

Kataranovski, D.,& Kataranovski, M.. (2021). Štetni glodari: biologija, epizootiologija, ekologija i kontrola brojnosti. 
Beograd: NNK Internacional., 1-1058.
https://hdl.handle.net/21.15107/rcub_ibiss_4781

Kataranovski D, Kataranovski M. Štetni glodari: biologija, epizootiologija, ekologija i kontrola brojnosti. 2021;:1-1058.
https://hdl.handle.net/21.15107/rcub_ibiss_4781 .

Kataranovski, Dragan, Kataranovski, Milena, "Štetni glodari: biologija, epizootiologija, ekologija i kontrola brojnosti" (2021):1-1058,
https://hdl.handle.net/21.15107/rcub_ibiss_4781 .

TY  - CONF
AU  - Tucović, Dina
AU  - Mirkov, Ivana
AU  - Kulaš, Jelena
AU  - Popović, Dušanka
AU  - Zolotarevski, Lidija
AU  - Despotović, Marta
AU  - Kataranovski, Milena
AU  - Popov Aleksandrov, Aleksandra
PY  - 2021
UR  - https://onlinelibrary.wiley.com/toc/15214141/2021/51/S1
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/4882
AB  - Cadmium (Cd) in food and drinking water presents a health risk to the general population. We have shown previously that orally‐acquired Cd affects basal immune homeostasis in the skin. In this study, we examined the effect of 30‐days oral exposure of inflammatory disease‐prone Dark Agouti (DA) rats to two environmentally relevant Cd doses (5 and 50 ppm) on contact hypersensitivity reaction (CHS) induced by topical 0,4% dinitrochlorobenzene (DNCB). Both Cd doses increased proinflammatory epidermal cell response (IL‐1, TNF and IL‐6 production) to DNCB sensitization, as well as epidermal cells’ potential to stimulate naïve lymphocytes ex vivo (increased IFN‐γ and IL‐17 production in co‐cultures). The proinflammatory milieu of epidermal cells induced by sensitization was accompanied by increased hapten‐specific production of IFN‐γ (at a lower Cd dose) and IL‐17 (at both Cd doses) by draining lymph node (DLN) cells, compared to Cd non‐treated animals. During the challenge phase of CHS, oral Cd increased ear swelling response and skin inflammation (edema, mononuclear and neutrophil cell infiltration) at both Cd doses, what correlated with increased innate (TNF) and hapten‐specific effector (IFN‐γ, IL‐17) cytokine response by ear cells. Even in Albino Oxford (AO) rats generally less prone to inflammation, oral Cd increased the proinflammatory response of epidermal cells following sensitization, however, DLN cell responses were absent. Ear swelling response to hapten challenge was observed in AO individuals which acquired a higher Cd dose. Presented data imply the potential of food‐ and water‐borne Cd to be risk factors for skin disease development and/or its exacerbation.
PB  - Wiley‐VCH GmbH
C3  - 6th European Congress of Immunology; 2021 Sep 1-4; Virtual Meeting
T1  - Oral cadmium increases contact hypersensitivity reaction in rats
DO  - 10.1002/eji.202170200
SP  - 348
ER  - 

@conference{
author = "Tucović, Dina and Mirkov, Ivana and Kulaš, Jelena and Popović, Dušanka and Zolotarevski, Lidija and Despotović, Marta and Kataranovski, Milena and Popov Aleksandrov, Aleksandra",
year = "2021",
abstract = "Cadmium (Cd) in food and drinking water presents a health risk to the general population. We have shown previously that orally‐acquired Cd affects basal immune homeostasis in the skin. In this study, we examined the effect of 30‐days oral exposure of inflammatory disease‐prone Dark Agouti (DA) rats to two environmentally relevant Cd doses (5 and 50 ppm) on contact hypersensitivity reaction (CHS) induced by topical 0,4% dinitrochlorobenzene (DNCB). Both Cd doses increased proinflammatory epidermal cell response (IL‐1, TNF and IL‐6 production) to DNCB sensitization, as well as epidermal cells’ potential to stimulate naïve lymphocytes ex vivo (increased IFN‐γ and IL‐17 production in co‐cultures). The proinflammatory milieu of epidermal cells induced by sensitization was accompanied by increased hapten‐specific production of IFN‐γ (at a lower Cd dose) and IL‐17 (at both Cd doses) by draining lymph node (DLN) cells, compared to Cd non‐treated animals. During the challenge phase of CHS, oral Cd increased ear swelling response and skin inflammation (edema, mononuclear and neutrophil cell infiltration) at both Cd doses, what correlated with increased innate (TNF) and hapten‐specific effector (IFN‐γ, IL‐17) cytokine response by ear cells. Even in Albino Oxford (AO) rats generally less prone to inflammation, oral Cd increased the proinflammatory response of epidermal cells following sensitization, however, DLN cell responses were absent. Ear swelling response to hapten challenge was observed in AO individuals which acquired a higher Cd dose. Presented data imply the potential of food‐ and water‐borne Cd to be risk factors for skin disease development and/or its exacerbation.",
publisher = "Wiley‐VCH GmbH",
journal = "6th European Congress of Immunology; 2021 Sep 1-4; Virtual Meeting",
title = "Oral cadmium increases contact hypersensitivity reaction in rats",
doi = "10.1002/eji.202170200",
pages = "348"
}

Tucović, D., Mirkov, I., Kulaš, J., Popović, D., Zolotarevski, L., Despotović, M., Kataranovski, M.,& Popov Aleksandrov, A.. (2021). Oral cadmium increases contact hypersensitivity reaction in rats. in 6th European Congress of Immunology; 2021 Sep 1-4; Virtual Meeting
Wiley‐VCH GmbH., 348.
https://doi.org/10.1002/eji.202170200

Tucović D, Mirkov I, Kulaš J, Popović D, Zolotarevski L, Despotović M, Kataranovski M, Popov Aleksandrov A. Oral cadmium increases contact hypersensitivity reaction in rats. in 6th European Congress of Immunology; 2021 Sep 1-4; Virtual Meeting. 2021;:348.
doi:10.1002/eji.202170200 .

Tucović, Dina, Mirkov, Ivana, Kulaš, Jelena, Popović, Dušanka, Zolotarevski, Lidija, Despotović, Marta, Kataranovski, Milena, Popov Aleksandrov, Aleksandra, "Oral cadmium increases contact hypersensitivity reaction in rats" in 6th European Congress of Immunology; 2021 Sep 1-4; Virtual Meeting (2021):348,
https://doi.org/10.1002/eji.202170200 . .

TY  - JOUR
AU  - Kulaš, Jelena
AU  - Tucović, Dina
AU  - Zeljković, Milica
AU  - Popović, Dušanka
AU  - Popov Aleksandrov, Aleksandra
AU  - Ukropina, Mirela
AU  - Cakić Milošević, Maja
AU  - Glamočlija, Jasmina
AU  - Kataranovski, Milena
AU  - Mirkov, Ivana
PY  - 2021
UR  - https://linkinghub.elsevier.com/retrieve/pii/S0300483X20302730
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4033
AB  - Cadmium (Cd) is one of the most toxic environmental heavy metals to which the general population is exposed mainly via the oral route. Owing to its immunomodulatory potential, orally acquired Cd affects antimicrobial immune defense in several organs, including the lungs. While there are data concerning Cd and viral and bacterial pulmonary infections, effects on fungal infections are not studied yet. In the present study, the effect of the Cd (5 mg/L for 30 days, in drinking water, the average daily Cd intake 0.641 ± 0.089 mg/kg) on the immune response of rats to pulmonary A. fumigatus infection was examined. Data obtained showed that orally acquired cadmium does not affect the elimination of the fungus in immunocompetent rats owing to the preservation of some aspects of innate immune responses (lung leukocyte infiltration and NBT reduction) and an increase in other (increased numbers of mucus-producing goblet cells, MPO release). Cd does not affect an IFN-γ response in lung leukocytes during the infection (despite suppression of cytokine production in cells of lung-draining lymph nodes), while it stimulates IL-17 and suppresses IL-10 response to the fungus. As a result, the elimination of the fungus occurs in a milieu with the prevailing proinflammatory response in Cd-exposed animals that preserved fungal elimination from the lungs, though with more intense injury to the lung tissue. Therefore, the proinflammatory microenvironment in the lungs created by Cd that sustains inflammatory/immune response to the fungus to which humans are exposed for a lifetime, raises a concern of orally acquired Cd as a risk factor for the development of chronic low-grade pulmonary inflammation.
PB  - Elsevier Ireland Ltd
T2  - Toxicology
T2  - Toxicology
T1  - Proinflammatory effects of environmental cadmium boost resistance to opportunistic pathogen Aspergillus fumigatus: Implications for sustained low-level pulmonary inflammation?
VL  - 447
DO  - 10.1016/j.tox.2020.152634
SP  - 152634
ER  - 

@article{
author = "Kulaš, Jelena and Tucović, Dina and Zeljković, Milica and Popović, Dušanka and Popov Aleksandrov, Aleksandra and Ukropina, Mirela and Cakić Milošević, Maja and Glamočlija, Jasmina and Kataranovski, Milena and Mirkov, Ivana",
year = "2021",
abstract = "Cadmium (Cd) is one of the most toxic environmental heavy metals to which the general population is exposed mainly via the oral route. Owing to its immunomodulatory potential, orally acquired Cd affects antimicrobial immune defense in several organs, including the lungs. While there are data concerning Cd and viral and bacterial pulmonary infections, effects on fungal infections are not studied yet. In the present study, the effect of the Cd (5 mg/L for 30 days, in drinking water, the average daily Cd intake 0.641 ± 0.089 mg/kg) on the immune response of rats to pulmonary A. fumigatus infection was examined. Data obtained showed that orally acquired cadmium does not affect the elimination of the fungus in immunocompetent rats owing to the preservation of some aspects of innate immune responses (lung leukocyte infiltration and NBT reduction) and an increase in other (increased numbers of mucus-producing goblet cells, MPO release). Cd does not affect an IFN-γ response in lung leukocytes during the infection (despite suppression of cytokine production in cells of lung-draining lymph nodes), while it stimulates IL-17 and suppresses IL-10 response to the fungus. As a result, the elimination of the fungus occurs in a milieu with the prevailing proinflammatory response in Cd-exposed animals that preserved fungal elimination from the lungs, though with more intense injury to the lung tissue. Therefore, the proinflammatory microenvironment in the lungs created by Cd that sustains inflammatory/immune response to the fungus to which humans are exposed for a lifetime, raises a concern of orally acquired Cd as a risk factor for the development of chronic low-grade pulmonary inflammation.",
publisher = "Elsevier Ireland Ltd",
journal = "Toxicology, Toxicology",
title = "Proinflammatory effects of environmental cadmium boost resistance to opportunistic pathogen Aspergillus fumigatus: Implications for sustained low-level pulmonary inflammation?",
volume = "447",
doi = "10.1016/j.tox.2020.152634",
pages = "152634"
}

Kulaš, J., Tucović, D., Zeljković, M., Popović, D., Popov Aleksandrov, A., Ukropina, M., Cakić Milošević, M., Glamočlija, J., Kataranovski, M.,& Mirkov, I.. (2021). Proinflammatory effects of environmental cadmium boost resistance to opportunistic pathogen Aspergillus fumigatus: Implications for sustained low-level pulmonary inflammation?. in Toxicology
Elsevier Ireland Ltd., 447, 152634.
https://doi.org/10.1016/j.tox.2020.152634

Kulaš J, Tucović D, Zeljković M, Popović D, Popov Aleksandrov A, Ukropina M, Cakić Milošević M, Glamočlija J, Kataranovski M, Mirkov I. Proinflammatory effects of environmental cadmium boost resistance to opportunistic pathogen Aspergillus fumigatus: Implications for sustained low-level pulmonary inflammation?. in Toxicology. 2021;447:152634.
doi:10.1016/j.tox.2020.152634 .

Kulaš, Jelena, Tucović, Dina, Zeljković, Milica, Popović, Dušanka, Popov Aleksandrov, Aleksandra, Ukropina, Mirela, Cakić Milošević, Maja, Glamočlija, Jasmina, Kataranovski, Milena, Mirkov, Ivana, "Proinflammatory effects of environmental cadmium boost resistance to opportunistic pathogen Aspergillus fumigatus: Implications for sustained low-level pulmonary inflammation?" in Toxicology, 447 (2021):152634,
https://doi.org/10.1016/j.tox.2020.152634 . .

TY  - JOUR
AU  - Kulaš, Jelena
AU  - Tucović, Dina
AU  - Zeljković, Milica
AU  - Popović, Dušanka
AU  - Popov Aleksandrov, Aleksandra
AU  - Kataranovski, Milena
AU  - Mirkov, Ivana
PY  - 2021
UR  - http://www.besjournal.com/en/article/doi/10.3967/bes2021.025
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4191
AB  - Objective To investigate involvement of the aryl hydrocarbon receptor (AhR) in the immunomodulatory effects of cadmium (Cd). Methods The effect of Cd on AhR activation ( CYP1A1 and CYP1B1 mRNA expression) was examined in lung leukocytes of Cd-exposed rats (5 and 50 mg/L, 30 d orally) and by in vitro leukocyte exposure. The involvement of AhR signaling in the effects of Cd on the interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF) lung leukocyte response was investigated in vitro using the receptor antagonist CH-223191. Results Cd increased CYP1B1 ( in vivo and in vitro) and CYP1A1 ( in vitro) mRNA, indicating AhR involvement in the action of Cd. In response to Cd, lung leukocytes increased IL-6 and decreased TNF at the gene expression and protein levels, but decreased IL-1β production due to reduced NLRP3. The AhR antagonist CH-223191 abrogated the observed effects of Cd on the cytokine response. The absence of AhR reactivity and cytokine response to Cd of leukocytes from the lungs of a rat strain that is less sensitive to Cd toxicity coincided with a high AhR repressor mRNA level. Conclusion AhR signaling is involved in the lung leukocyte proinflammatory cytokine response to Cd. The relevance of the AhR to the cytokine response to Cd provides new insight into the mechanisms of Cd immunotoxicity.
PB  - Elsevier Ltd
T2  - Biomedical and Environmental Sciences
T1  - Aryl Hydrocarbon Receptor is Involved in the Proinflammatory Cytokine Response to Cadmium.
IS  - 3
VL  - 34
DO  - 10.3967/bes2021.025
SP  - 192
EP  - 202
ER  - 

@article{
author = "Kulaš, Jelena and Tucović, Dina and Zeljković, Milica and Popović, Dušanka and Popov Aleksandrov, Aleksandra and Kataranovski, Milena and Mirkov, Ivana",
year = "2021",
abstract = "Objective To investigate involvement of the aryl hydrocarbon receptor (AhR) in the immunomodulatory effects of cadmium (Cd). Methods The effect of Cd on AhR activation ( CYP1A1 and CYP1B1 mRNA expression) was examined in lung leukocytes of Cd-exposed rats (5 and 50 mg/L, 30 d orally) and by in vitro leukocyte exposure. The involvement of AhR signaling in the effects of Cd on the interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF) lung leukocyte response was investigated in vitro using the receptor antagonist CH-223191. Results Cd increased CYP1B1 ( in vivo and in vitro) and CYP1A1 ( in vitro) mRNA, indicating AhR involvement in the action of Cd. In response to Cd, lung leukocytes increased IL-6 and decreased TNF at the gene expression and protein levels, but decreased IL-1β production due to reduced NLRP3. The AhR antagonist CH-223191 abrogated the observed effects of Cd on the cytokine response. The absence of AhR reactivity and cytokine response to Cd of leukocytes from the lungs of a rat strain that is less sensitive to Cd toxicity coincided with a high AhR repressor mRNA level. Conclusion AhR signaling is involved in the lung leukocyte proinflammatory cytokine response to Cd. The relevance of the AhR to the cytokine response to Cd provides new insight into the mechanisms of Cd immunotoxicity.",
publisher = "Elsevier Ltd",
journal = "Biomedical and Environmental Sciences",
title = "Aryl Hydrocarbon Receptor is Involved in the Proinflammatory Cytokine Response to Cadmium.",
number = "3",
volume = "34",
doi = "10.3967/bes2021.025",
pages = "192-202"
}

Kulaš, J., Tucović, D., Zeljković, M., Popović, D., Popov Aleksandrov, A., Kataranovski, M.,& Mirkov, I.. (2021). Aryl Hydrocarbon Receptor is Involved in the Proinflammatory Cytokine Response to Cadmium.. in Biomedical and Environmental Sciences
Elsevier Ltd., 34(3), 192-202.
https://doi.org/10.3967/bes2021.025

Kulaš J, Tucović D, Zeljković M, Popović D, Popov Aleksandrov A, Kataranovski M, Mirkov I. Aryl Hydrocarbon Receptor is Involved in the Proinflammatory Cytokine Response to Cadmium.. in Biomedical and Environmental Sciences. 2021;34(3):192-202.
doi:10.3967/bes2021.025 .

Kulaš, Jelena, Tucović, Dina, Zeljković, Milica, Popović, Dušanka, Popov Aleksandrov, Aleksandra, Kataranovski, Milena, Mirkov, Ivana, "Aryl Hydrocarbon Receptor is Involved in the Proinflammatory Cytokine Response to Cadmium." in Biomedical and Environmental Sciences, 34, no. 3 (2021):192-202,
https://doi.org/10.3967/bes2021.025 . .

TY  - JOUR
AU  - Popov Aleksandrov, Aleksandra
AU  - Mirkov, Ivana
AU  - Tucović, Dina
AU  - Kulaš, Jelena
AU  - Zeljković, Milica
AU  - Popović, Dušanka
AU  - Ninkov, Marina
AU  - Janković, Srđa
AU  - Kataranovski, Milena
PY  - 2021
UR  - https://linkinghub.elsevier.com/retrieve/pii/S0165247821001644
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/4664
AB  - Cadmium (Cd) represents a unique hazard because of the long biological half-life in humans (20-30 years). This metal accumulates in organs causing a continuum of responses, with organ disease/failure as extreme outcome. Some of the cellular and molecular alterations in target tissues can be related to immune-modulating potential of Cd. This metal may cause adverse responses in which components of the immune system function as both mediators and effectors of Cd tissue toxicity, which, in combination with Cd-induced alterations in homeostatic reparative activities may contribute to tissue dysfunction. In this work, current knowledge concerning inflammatory/autoimmune disease manifestations found to be related with cadmium exposure are summarized. Along with epidemiological evidence, animal and in vitro data are presented, with focus on cellular and molecular immune mechanisms potentially relevant for the disease susceptibility, disease promotion, or facilitating development of pre-existing pathologies.
PB  - Elsevier B.V.
T2  - Immunology Letters
T1  - Immunomodulation by heavy metals as a contributing factor to inflammatory diseases and autoimmune reactions: Cadmium as an example.
VL  - 240
DO  - 10.1016/j.imlet.2021.10.003
SP  - 106
EP  - 122
ER  - 

@article{
author = "Popov Aleksandrov, Aleksandra and Mirkov, Ivana and Tucović, Dina and Kulaš, Jelena and Zeljković, Milica and Popović, Dušanka and Ninkov, Marina and Janković, Srđa and Kataranovski, Milena",
year = "2021",
abstract = "Cadmium (Cd) represents a unique hazard because of the long biological half-life in humans (20-30 years). This metal accumulates in organs causing a continuum of responses, with organ disease/failure as extreme outcome. Some of the cellular and molecular alterations in target tissues can be related to immune-modulating potential of Cd. This metal may cause adverse responses in which components of the immune system function as both mediators and effectors of Cd tissue toxicity, which, in combination with Cd-induced alterations in homeostatic reparative activities may contribute to tissue dysfunction. In this work, current knowledge concerning inflammatory/autoimmune disease manifestations found to be related with cadmium exposure are summarized. Along with epidemiological evidence, animal and in vitro data are presented, with focus on cellular and molecular immune mechanisms potentially relevant for the disease susceptibility, disease promotion, or facilitating development of pre-existing pathologies.",
publisher = "Elsevier B.V.",
journal = "Immunology Letters",
title = "Immunomodulation by heavy metals as a contributing factor to inflammatory diseases and autoimmune reactions: Cadmium as an example.",
volume = "240",
doi = "10.1016/j.imlet.2021.10.003",
pages = "106-122"
}

Popov Aleksandrov, A., Mirkov, I., Tucović, D., Kulaš, J., Zeljković, M., Popović, D., Ninkov, M., Janković, S.,& Kataranovski, M.. (2021). Immunomodulation by heavy metals as a contributing factor to inflammatory diseases and autoimmune reactions: Cadmium as an example.. in Immunology Letters
Elsevier B.V.., 240, 106-122.
https://doi.org/10.1016/j.imlet.2021.10.003

Popov Aleksandrov A, Mirkov I, Tucović D, Kulaš J, Zeljković M, Popović D, Ninkov M, Janković S, Kataranovski M. Immunomodulation by heavy metals as a contributing factor to inflammatory diseases and autoimmune reactions: Cadmium as an example.. in Immunology Letters. 2021;240:106-122.
doi:10.1016/j.imlet.2021.10.003 .

Popov Aleksandrov, Aleksandra, Mirkov, Ivana, Tucović, Dina, Kulaš, Jelena, Zeljković, Milica, Popović, Dušanka, Ninkov, Marina, Janković, Srđa, Kataranovski, Milena, "Immunomodulation by heavy metals as a contributing factor to inflammatory diseases and autoimmune reactions: Cadmium as an example." in Immunology Letters, 240 (2021):106-122,
https://doi.org/10.1016/j.imlet.2021.10.003 . .

TY  - JOUR
AU  - Mirkov, Ivana
AU  - Popov Aleksandrov, Aleksandra
AU  - Ninkov, Marina
AU  - Tucović, Dina
AU  - Kulaš, Jelena
AU  - Zeljković, Milica
AU  - Popović, Dušanka
AU  - Kataranovski, Milena
PY  - 2021
UR  - http://www.ncbi.nlm.nih.gov/pubmed/33508420
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4150
AB  - Cadmium (Cd) has been listed as one of the most toxic substances affecting numerous tissues/organs, including the immune system. Due to variations in studies examining Cd effects on the immune system (exposure regime, experimental systems, immune endpoint measured), data on Cd immunotoxicity in humans and experimental animals are inconsistent. However, it is clear that Cd can affect cells of the immune system and can modulate some immune responses. Due to the complex nature of the immune system and its activities which are determined by multiple interactions, the underlying mechanisms involved in the immunotoxicity of this metal are still vague. Here, the current knowledge regarding the interaction of Cd with cells of the immune system, which may affect immune responses as well as potential mechanisms of consequent biological effects of such activities, is reviewed. Tissue injury caused by Cd-induced effects on innate cell activities depicts components of the immune system as mediators/effectors of Cd tissue toxicity. Cd-induced immune alterations, which may compromise host defense against pathogenic microorganisms and homeostatic reparative activities, stress this metal as an important health hazard.
PB  - Elsevier BV
T2  - Food and Chemical Toxicology
T1  - Immunotoxicology of cadmium: Cells of the immune system as targets and effectors of cadmium toxicity.
VL  - 149
DO  - 10.1016/j.fct.2021.112026
SP  - 112026
ER  - 

@article{
author = "Mirkov, Ivana and Popov Aleksandrov, Aleksandra and Ninkov, Marina and Tucović, Dina and Kulaš, Jelena and Zeljković, Milica and Popović, Dušanka and Kataranovski, Milena",
year = "2021",
abstract = "Cadmium (Cd) has been listed as one of the most toxic substances affecting numerous tissues/organs, including the immune system. Due to variations in studies examining Cd effects on the immune system (exposure regime, experimental systems, immune endpoint measured), data on Cd immunotoxicity in humans and experimental animals are inconsistent. However, it is clear that Cd can affect cells of the immune system and can modulate some immune responses. Due to the complex nature of the immune system and its activities which are determined by multiple interactions, the underlying mechanisms involved in the immunotoxicity of this metal are still vague. Here, the current knowledge regarding the interaction of Cd with cells of the immune system, which may affect immune responses as well as potential mechanisms of consequent biological effects of such activities, is reviewed. Tissue injury caused by Cd-induced effects on innate cell activities depicts components of the immune system as mediators/effectors of Cd tissue toxicity. Cd-induced immune alterations, which may compromise host defense against pathogenic microorganisms and homeostatic reparative activities, stress this metal as an important health hazard.",
publisher = "Elsevier BV",
journal = "Food and Chemical Toxicology",
title = "Immunotoxicology of cadmium: Cells of the immune system as targets and effectors of cadmium toxicity.",
volume = "149",
doi = "10.1016/j.fct.2021.112026",
pages = "112026"
}

Mirkov, I., Popov Aleksandrov, A., Ninkov, M., Tucović, D., Kulaš, J., Zeljković, M., Popović, D.,& Kataranovski, M.. (2021). Immunotoxicology of cadmium: Cells of the immune system as targets and effectors of cadmium toxicity.. in Food and Chemical Toxicology
Elsevier BV., 149, 112026.
https://doi.org/10.1016/j.fct.2021.112026

Mirkov I, Popov Aleksandrov A, Ninkov M, Tucović D, Kulaš J, Zeljković M, Popović D, Kataranovski M. Immunotoxicology of cadmium: Cells of the immune system as targets and effectors of cadmium toxicity.. in Food and Chemical Toxicology. 2021;149:112026.
doi:10.1016/j.fct.2021.112026 .

Mirkov, Ivana, Popov Aleksandrov, Aleksandra, Ninkov, Marina, Tucović, Dina, Kulaš, Jelena, Zeljković, Milica, Popović, Dušanka, Kataranovski, Milena, "Immunotoxicology of cadmium: Cells of the immune system as targets and effectors of cadmium toxicity." in Food and Chemical Toxicology, 149 (2021):112026,
https://doi.org/10.1016/j.fct.2021.112026 . .

TY  - JOUR
AU  - Popov Aleksandrov, Aleksandra
AU  - Mirkov, Ivana
AU  - Tucović, Dina
AU  - Kulaš, Jelena
AU  - Ninkov, Marina
AU  - Kataranovski, Milena
PY  - 2021
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4076
AB  - Cadmium (Cd) is a toxic heavy metal that when absorbed into the body causes nephrotoxicity and effects in other tissues.Anatomical barrier tissues are tissues that prevent the entry of pathogens and include skin, mucus membranes and the immune system. The adverse effects of Cd-induced immune cell's activity are the most extensively studied in the kidneys and the liver. There are though fewer data relating the effect of this metal on the other tissues, particularly in those in which cells of the immune system form local circuits of tissue defense, maintaining immune-mediated homeostasis. In this work, data on the direct and indirect effects of Cd on anatomical barrier tissue of inner and outer body surfaces (the lungs, gut, reproductive organs, and skin) were summarized.
PB  - Elsevier Ireland Ltd
T2  - Toxicology Letters
T1  - Cadmium and immunologically-mediated homeostasis of anatomical barrier tissues
VL  - 337
DO  - 10.1016/j.toxlet.2020.11.008
SP  - 38
EP  - 45
ER  - 

@article{
author = "Popov Aleksandrov, Aleksandra and Mirkov, Ivana and Tucović, Dina and Kulaš, Jelena and Ninkov, Marina and Kataranovski, Milena",
year = "2021",
abstract = "Cadmium (Cd) is a toxic heavy metal that when absorbed into the body causes nephrotoxicity and effects in other tissues.Anatomical barrier tissues are tissues that prevent the entry of pathogens and include skin, mucus membranes and the immune system. The adverse effects of Cd-induced immune cell's activity are the most extensively studied in the kidneys and the liver. There are though fewer data relating the effect of this metal on the other tissues, particularly in those in which cells of the immune system form local circuits of tissue defense, maintaining immune-mediated homeostasis. In this work, data on the direct and indirect effects of Cd on anatomical barrier tissue of inner and outer body surfaces (the lungs, gut, reproductive organs, and skin) were summarized.",
publisher = "Elsevier Ireland Ltd",
journal = "Toxicology Letters",
title = "Cadmium and immunologically-mediated homeostasis of anatomical barrier tissues",
volume = "337",
doi = "10.1016/j.toxlet.2020.11.008",
pages = "38-45"
}

Popov Aleksandrov, A., Mirkov, I., Tucović, D., Kulaš, J., Ninkov, M.,& Kataranovski, M.. (2021). Cadmium and immunologically-mediated homeostasis of anatomical barrier tissues. in Toxicology Letters
Elsevier Ireland Ltd., 337, 38-45.
https://doi.org/10.1016/j.toxlet.2020.11.008

Popov Aleksandrov A, Mirkov I, Tucović D, Kulaš J, Ninkov M, Kataranovski M. Cadmium and immunologically-mediated homeostasis of anatomical barrier tissues. in Toxicology Letters. 2021;337:38-45.
doi:10.1016/j.toxlet.2020.11.008 .

Popov Aleksandrov, Aleksandra, Mirkov, Ivana, Tucović, Dina, Kulaš, Jelena, Ninkov, Marina, Kataranovski, Milena, "Cadmium and immunologically-mediated homeostasis of anatomical barrier tissues" in Toxicology Letters, 337 (2021):38-45,
https://doi.org/10.1016/j.toxlet.2020.11.008 . .

TY  - JOUR
AU  - Tucović, Dina
AU  - Mirkov, Ivana
AU  - Kulaš, Jelena
AU  - Zeljković, Milica
AU  - Popović, Dušanka
AU  - Zolotarevski, Lidija
AU  - Đuđjić, Slađana
AU  - Mutić, Jelena
AU  - Kataranovski, Milena
AU  - Popov Aleksandrov, Aleksandra
PY  - 2020
UR  - internal-pdf://Tucovic et al. - 2020 - Dermatotoxicity of oral cadmium is strain-dependent and related to differences in skin stress response and infla.pdf
UR  - http://www.ncbi.nlm.nih.gov/pubmed/31924569
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3594
AB  - Adverse effects of non-occupational exposure to cadmium (Cd) are increasingly acknowledged. Since our previous study has showed that orally acquired Cd affects skin, the contribution of genetic background to dermatotoxicity of oral cadmium was examined in two rat strains, Albino Oxford (AO) and Dark Agouti (DA), which differed in response to chemicals. While similar accumulation of Cd in the skin of both strains was noted, the skin response to the metal differed. DA rat individuals mounted antioxidant enzyme defense in the skin already at lower Cd dose, in contrast to AO rats which reacted to higher metal dose solely (and less pronounced), implying higher susceptibility of DA strain to Cd dermatotoxicity. Epidermal cells from both strains developed stress response, but higher intensity of antioxidant response in AO rats implied this strain`s better ability to defend against Cd insult. Cd induced epidermal cells' proinflammatory cytokine response only in DA rats. Increased IL-10 seems responsible for the lack of response in AO rats. Differences in the pattern of skin/epidermal cell responsiveness to cadmium give a new insight into repercussion of genetic variability to dermatotoxicity of orally acquired cadmium, bearing relevance for variations in the link between dietary cadmium and inflammation-based skin pathologies.
T2  - Environmental Toxicology and Pharmacology
T1  - Dermatotoxicity of oral cadmium is strain-dependent and related to differences in skin stress response and inflammatory/immune activity.
VL  - 75
DO  - 10.1016/j.etap.2020.103326
SP  - 103326
ER  - 

@article{
author = "Tucović, Dina and Mirkov, Ivana and Kulaš, Jelena and Zeljković, Milica and Popović, Dušanka and Zolotarevski, Lidija and Đuđjić, Slađana and Mutić, Jelena and Kataranovski, Milena and Popov Aleksandrov, Aleksandra",
year = "2020",
abstract = "Adverse effects of non-occupational exposure to cadmium (Cd) are increasingly acknowledged. Since our previous study has showed that orally acquired Cd affects skin, the contribution of genetic background to dermatotoxicity of oral cadmium was examined in two rat strains, Albino Oxford (AO) and Dark Agouti (DA), which differed in response to chemicals. While similar accumulation of Cd in the skin of both strains was noted, the skin response to the metal differed. DA rat individuals mounted antioxidant enzyme defense in the skin already at lower Cd dose, in contrast to AO rats which reacted to higher metal dose solely (and less pronounced), implying higher susceptibility of DA strain to Cd dermatotoxicity. Epidermal cells from both strains developed stress response, but higher intensity of antioxidant response in AO rats implied this strain`s better ability to defend against Cd insult. Cd induced epidermal cells' proinflammatory cytokine response only in DA rats. Increased IL-10 seems responsible for the lack of response in AO rats. Differences in the pattern of skin/epidermal cell responsiveness to cadmium give a new insight into repercussion of genetic variability to dermatotoxicity of orally acquired cadmium, bearing relevance for variations in the link between dietary cadmium and inflammation-based skin pathologies.",
journal = "Environmental Toxicology and Pharmacology",
title = "Dermatotoxicity of oral cadmium is strain-dependent and related to differences in skin stress response and inflammatory/immune activity.",
volume = "75",
doi = "10.1016/j.etap.2020.103326",
pages = "103326"
}

Tucović, D., Mirkov, I., Kulaš, J., Zeljković, M., Popović, D., Zolotarevski, L., Đuđjić, S., Mutić, J., Kataranovski, M.,& Popov Aleksandrov, A.. (2020). Dermatotoxicity of oral cadmium is strain-dependent and related to differences in skin stress response and inflammatory/immune activity.. in Environmental Toxicology and Pharmacology, 75, 103326.
https://doi.org/10.1016/j.etap.2020.103326

Tucović D, Mirkov I, Kulaš J, Zeljković M, Popović D, Zolotarevski L, Đuđjić S, Mutić J, Kataranovski M, Popov Aleksandrov A. Dermatotoxicity of oral cadmium is strain-dependent and related to differences in skin stress response and inflammatory/immune activity.. in Environmental Toxicology and Pharmacology. 2020;75:103326.
doi:10.1016/j.etap.2020.103326 .

Tucović, Dina, Mirkov, Ivana, Kulaš, Jelena, Zeljković, Milica, Popović, Dušanka, Zolotarevski, Lidija, Đuđjić, Slađana, Mutić, Jelena, Kataranovski, Milena, Popov Aleksandrov, Aleksandra, "Dermatotoxicity of oral cadmium is strain-dependent and related to differences in skin stress response and inflammatory/immune activity." in Environmental Toxicology and Pharmacology, 75 (2020):103326,
https://doi.org/10.1016/j.etap.2020.103326 . .

TY  - JOUR
AU  - Mirkov, Ivana
AU  - Popov Aleksandrov, Aleksandra
AU  - Lazović, B.
AU  - Glamočlija, Jasmina
AU  - Kataranovski, Milena
PY  - 2019
UR  - https://www.sciencedirect.com/science/article/pii/S1156523318301239?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3247
AB  - Aspergillosis represents a spectrum of fungal diseases which are caused by fungi of the genus Aspergillus. Animal models have been developed and used to address immune-based mechanisms of defense against these fungi. Invertebrate models enabled mass screening of virulence attributes of Aspergillus species as well as mechanisms of acquired resistance to antifungal agents. This review represents a concise view of cellular and humoral participants in an immune response to Aspergillus gained mostly from rodent models of aspergillosis. The survey of immune defense mechanisms was given, including the role of innate immune cells (macrophages, neutrophils, monocytes, eosinophils, innate-like lymphocytes) and receptors in antifungal response, the significance of dendritic cells in activation of specific adaptive T cell-mediated immune responses and the regulatory mechanisms of excessive response. Insight into innate immune defense mechanisms gained using non-vertebrate models of infections with Aspergillus sp. was given as well. The contribution of animal models to the current knowledge of immune mechanisms of resistance or susceptibility to these fungi was stressed and the significance of data gained from these models in forming the basis for the design of therapeutic strategies in prevention and/or treatment of aspergillosis was pointed out.
T2  - Journal de Mycologie Médicale
T1  - Usefulness of animal models of aspergillosis in studying immunity against Aspergillus infections.
IS  - 1
VL  - 29
DO  - 10.1016/j.mycmed.2019.01.006
SP  - 84
EP  - 96
ER  - 

@article{
author = "Mirkov, Ivana and Popov Aleksandrov, Aleksandra and Lazović, B. and Glamočlija, Jasmina and Kataranovski, Milena",
year = "2019",
abstract = "Aspergillosis represents a spectrum of fungal diseases which are caused by fungi of the genus Aspergillus. Animal models have been developed and used to address immune-based mechanisms of defense against these fungi. Invertebrate models enabled mass screening of virulence attributes of Aspergillus species as well as mechanisms of acquired resistance to antifungal agents. This review represents a concise view of cellular and humoral participants in an immune response to Aspergillus gained mostly from rodent models of aspergillosis. The survey of immune defense mechanisms was given, including the role of innate immune cells (macrophages, neutrophils, monocytes, eosinophils, innate-like lymphocytes) and receptors in antifungal response, the significance of dendritic cells in activation of specific adaptive T cell-mediated immune responses and the regulatory mechanisms of excessive response. Insight into innate immune defense mechanisms gained using non-vertebrate models of infections with Aspergillus sp. was given as well. The contribution of animal models to the current knowledge of immune mechanisms of resistance or susceptibility to these fungi was stressed and the significance of data gained from these models in forming the basis for the design of therapeutic strategies in prevention and/or treatment of aspergillosis was pointed out.",
journal = "Journal de Mycologie Médicale",
title = "Usefulness of animal models of aspergillosis in studying immunity against Aspergillus infections.",
number = "1",
volume = "29",
doi = "10.1016/j.mycmed.2019.01.006",
pages = "84-96"
}

Mirkov, I., Popov Aleksandrov, A., Lazović, B., Glamočlija, J.,& Kataranovski, M.. (2019). Usefulness of animal models of aspergillosis in studying immunity against Aspergillus infections.. in Journal de Mycologie Médicale, 29(1), 84-96.
https://doi.org/10.1016/j.mycmed.2019.01.006

Mirkov I, Popov Aleksandrov A, Lazović B, Glamočlija J, Kataranovski M. Usefulness of animal models of aspergillosis in studying immunity against Aspergillus infections.. in Journal de Mycologie Médicale. 2019;29(1):84-96.
doi:10.1016/j.mycmed.2019.01.006 .

Mirkov, Ivana, Popov Aleksandrov, Aleksandra, Lazović, B., Glamočlija, Jasmina, Kataranovski, Milena, "Usefulness of animal models of aspergillosis in studying immunity against Aspergillus infections." in Journal de Mycologie Médicale, 29, no. 1 (2019):84-96,
https://doi.org/10.1016/j.mycmed.2019.01.006 . .

TY  - CONF
AU  - Kulaš, Jelena
AU  - Tucović, Dina
AU  - Zeljković, Milica
AU  - Popović, Dušanka
AU  - Popov Aleksandrov, Aleksandra
AU  - Kataranovski, Milena
AU  - Mirkov, Ivana
PY  - 2019
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/4794
AB  - Cadmium (Cd) is a heavy metal widely spread in the environment and significant water and food contaminant. This metal exerts toxic effects in various tissues thus representing great threat to human health, and our previous study showed that oral consumption of Cd (in water for 30 days) increased the metal deposition and exerted immunomodulatory effects in lung leukocytes. Although the most studied mechanisms of Cd toxicity include oxidative stress and inflammation, recent studies have indicated that this metal can activate aryl hydrocarbon receptor (AHR) and exert effects on AHR-regulated genes (i.e. CYPs). AHR represents a link between environmental toxicants and immune response as high receptor expression is noted in immune cells and barrier tissues, thus the aim of presented study was to investigate if activation of AhR by Cd is associated with metals’ immunomodulatory effects. Treatment of lung leukocytes with Cd in vitro (non-toxic doses) caused an increase in mRNA levels for AHR, CYP1B1 and CYP1A1, but co-treatment with metal and AHR antagonist CH223191 indicated that higher Cd doses (5 and 10 μM) can activate CYPs directly while a lower dose (1 μM) exerted effects on CYPs expression through activation of AHR. Low Cd dose induced increased production of IL-6 and decreased TNF and IL-1β by lung leukocytes, compared to controls. Gene expression data revealed unchanged mRNA for IL-6, decreased TNF, but increased IL-1β. Lower IL-1β protein level despite increased mRNA, was a consequence of decreased mRNA for NLRP3, a component of inflammasome that is involved in processing of pro-IL-1β in IL-1β. All noted effects were abolished in the presence of CH223191. Data obtained indicate that immunomodulatory effects of low Cd dose are mediated through AHR activation.
PB  - Belgrade: Institute for Biological Research "Siniša Stanković"– National Institute of Republic of Serbia, University of Belgrade
C3  - Immunology at the Confluence of Multidisciplinary Approaches : abstract book
T1  - Environmentally relevant exposure to cadmium and health risks: involvement of aryl hydrocarbon receptor
SP  - 80
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_4794
ER  - 

@conference{
author = "Kulaš, Jelena and Tucović, Dina and Zeljković, Milica and Popović, Dušanka and Popov Aleksandrov, Aleksandra and Kataranovski, Milena and Mirkov, Ivana",
year = "2019",
abstract = "Cadmium (Cd) is a heavy metal widely spread in the environment and significant water and food contaminant. This metal exerts toxic effects in various tissues thus representing great threat to human health, and our previous study showed that oral consumption of Cd (in water for 30 days) increased the metal deposition and exerted immunomodulatory effects in lung leukocytes. Although the most studied mechanisms of Cd toxicity include oxidative stress and inflammation, recent studies have indicated that this metal can activate aryl hydrocarbon receptor (AHR) and exert effects on AHR-regulated genes (i.e. CYPs). AHR represents a link between environmental toxicants and immune response as high receptor expression is noted in immune cells and barrier tissues, thus the aim of presented study was to investigate if activation of AhR by Cd is associated with metals’ immunomodulatory effects. Treatment of lung leukocytes with Cd in vitro (non-toxic doses) caused an increase in mRNA levels for AHR, CYP1B1 and CYP1A1, but co-treatment with metal and AHR antagonist CH223191 indicated that higher Cd doses (5 and 10 μM) can activate CYPs directly while a lower dose (1 μM) exerted effects on CYPs expression through activation of AHR. Low Cd dose induced increased production of IL-6 and decreased TNF and IL-1β by lung leukocytes, compared to controls. Gene expression data revealed unchanged mRNA for IL-6, decreased TNF, but increased IL-1β. Lower IL-1β protein level despite increased mRNA, was a consequence of decreased mRNA for NLRP3, a component of inflammasome that is involved in processing of pro-IL-1β in IL-1β. All noted effects were abolished in the presence of CH223191. Data obtained indicate that immunomodulatory effects of low Cd dose are mediated through AHR activation.",
publisher = "Belgrade: Institute for Biological Research "Siniša Stanković"– National Institute of Republic of Serbia, University of Belgrade",
journal = "Immunology at the Confluence of Multidisciplinary Approaches : abstract book",
title = "Environmentally relevant exposure to cadmium and health risks: involvement of aryl hydrocarbon receptor",
pages = "80",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_4794"
}

Kulaš, J., Tucović, D., Zeljković, M., Popović, D., Popov Aleksandrov, A., Kataranovski, M.,& Mirkov, I.. (2019). Environmentally relevant exposure to cadmium and health risks: involvement of aryl hydrocarbon receptor. in Immunology at the Confluence of Multidisciplinary Approaches : abstract book
Belgrade: Institute for Biological Research "Siniša Stanković"– National Institute of Republic of Serbia, University of Belgrade., 80.
https://hdl.handle.net/21.15107/rcub_ibiss_4794

Kulaš J, Tucović D, Zeljković M, Popović D, Popov Aleksandrov A, Kataranovski M, Mirkov I. Environmentally relevant exposure to cadmium and health risks: involvement of aryl hydrocarbon receptor. in Immunology at the Confluence of Multidisciplinary Approaches : abstract book. 2019;:80.
https://hdl.handle.net/21.15107/rcub_ibiss_4794 .

Kulaš, Jelena, Tucović, Dina, Zeljković, Milica, Popović, Dušanka, Popov Aleksandrov, Aleksandra, Kataranovski, Milena, Mirkov, Ivana, "Environmentally relevant exposure to cadmium and health risks: involvement of aryl hydrocarbon receptor" in Immunology at the Confluence of Multidisciplinary Approaches : abstract book (2019):80,
https://hdl.handle.net/21.15107/rcub_ibiss_4794 .

TY  - CONF
AU  - Tucović, Dina
AU  - Mirkov, Ivana
AU  - Kulaš, Jelena
AU  - Zeljković, Milica
AU  - Popović, Dušanka
AU  - Zolotarevski, Lidija
AU  - Đurđić, Slađana
AU  - Mutić, Jelena
AU  - Kataranovski, Milena
AU  - Popov Aleksandrov, Aleksandra
PY  - 2019
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/4795
AB  - Adverse effects of non-occupational exposure to cadmium (Cd) are increasingly
acknowledged. Using a rat model of oral Cd exposure in drinking water we have shown
that skin is a target for this metal. Due to contribution of individual variability to the
intensity of cadmium toxicity, dermatotoxicity of two environmentally relevant Cd
doses (5 and 50 ppm) was examined in individuals of two rat strains, Albino Oxford
(AO) and Dark Agouti (DA), which differ in response to chemicals. A dose-dependent
accumulation of Cd in the skin/epidermal cells was noted in both strains, and although
there were no strain differences in the Cd accumulation, the degree of skin response to
the metal differed. Signs of skin damage were evident in both strains, but response to
injury was more pronounced in DA. Individuals of DA rats responded by an increase
in the levels of antioxidant defense enzymes in the skin already at lower dose, in
contrast to AO (which reacted to higher dose solely), implying higher sensitivity of DA
strain to Cd-induced toxicity. Epidermal cells from both strains developed stress
response, however increased GSH, and higher metallothionein/MT-1 and MT-2
mRNA, Nrf2 protein, apoptosis, Ahr and Cyp genes in AO, depicting this strain`s
ability to better defend against Cd insult. Epidermal cells` IL-1β, TNF and IL-6
response was induced by Cd in DA, while pro-inflammatory cytokine production was
unchanged in AO (though increased following stimulation with S. epidermidis), with
increased IL-10 as a possible underlying mechanism. T cells from non-exposed rats
produce more IFN-γ and IL-17 in co-culture with epidermal cell from Cd–exposed DA
rats what strengthens the view that this strain is more prone to metal’s dermatotoxicity.
These data give a new insight into repercussion of genetic variability to toxicity of
cadmium acquired by the skin via gut, bearing relevance for variations in the link
between dietary cadmium and inflammation-based skin pathologies.
PB  - Belgrade: Institute for Biological Research "Siniša Stanković"– National Institute of Republic of Serbia, University of Belgrade
C3  - Immunology at the Confluence of Multidisciplinary Approaches : abstract book
T1  - Environmentally relevant exposure to cadmium and health risks: skin as target organ
SP  - 79
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_4795
ER  - 

@conference{
author = "Tucović, Dina and Mirkov, Ivana and Kulaš, Jelena and Zeljković, Milica and Popović, Dušanka and Zolotarevski, Lidija and Đurđić, Slađana and Mutić, Jelena and Kataranovski, Milena and Popov Aleksandrov, Aleksandra",
year = "2019",
abstract = "Adverse effects of non-occupational exposure to cadmium (Cd) are increasingly
acknowledged. Using a rat model of oral Cd exposure in drinking water we have shown
that skin is a target for this metal. Due to contribution of individual variability to the
intensity of cadmium toxicity, dermatotoxicity of two environmentally relevant Cd
doses (5 and 50 ppm) was examined in individuals of two rat strains, Albino Oxford
(AO) and Dark Agouti (DA), which differ in response to chemicals. A dose-dependent
accumulation of Cd in the skin/epidermal cells was noted in both strains, and although
there were no strain differences in the Cd accumulation, the degree of skin response to
the metal differed. Signs of skin damage were evident in both strains, but response to
injury was more pronounced in DA. Individuals of DA rats responded by an increase
in the levels of antioxidant defense enzymes in the skin already at lower dose, in
contrast to AO (which reacted to higher dose solely), implying higher sensitivity of DA
strain to Cd-induced toxicity. Epidermal cells from both strains developed stress
response, however increased GSH, and higher metallothionein/MT-1 and MT-2
mRNA, Nrf2 protein, apoptosis, Ahr and Cyp genes in AO, depicting this strain`s
ability to better defend against Cd insult. Epidermal cells` IL-1β, TNF and IL-6
response was induced by Cd in DA, while pro-inflammatory cytokine production was
unchanged in AO (though increased following stimulation with S. epidermidis), with
increased IL-10 as a possible underlying mechanism. T cells from non-exposed rats
produce more IFN-γ and IL-17 in co-culture with epidermal cell from Cd–exposed DA
rats what strengthens the view that this strain is more prone to metal’s dermatotoxicity.
These data give a new insight into repercussion of genetic variability to toxicity of
cadmium acquired by the skin via gut, bearing relevance for variations in the link
between dietary cadmium and inflammation-based skin pathologies.",
publisher = "Belgrade: Institute for Biological Research "Siniša Stanković"– National Institute of Republic of Serbia, University of Belgrade",
journal = "Immunology at the Confluence of Multidisciplinary Approaches : abstract book",
title = "Environmentally relevant exposure to cadmium and health risks: skin as target organ",
pages = "79",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_4795"
}

Tucović, D., Mirkov, I., Kulaš, J., Zeljković, M., Popović, D., Zolotarevski, L., Đurđić, S., Mutić, J., Kataranovski, M.,& Popov Aleksandrov, A.. (2019). Environmentally relevant exposure to cadmium and health risks: skin as target organ. in Immunology at the Confluence of Multidisciplinary Approaches : abstract book
Belgrade: Institute for Biological Research "Siniša Stanković"– National Institute of Republic of Serbia, University of Belgrade., 79.
https://hdl.handle.net/21.15107/rcub_ibiss_4795

Tucović D, Mirkov I, Kulaš J, Zeljković M, Popović D, Zolotarevski L, Đurđić S, Mutić J, Kataranovski M, Popov Aleksandrov A. Environmentally relevant exposure to cadmium and health risks: skin as target organ. in Immunology at the Confluence of Multidisciplinary Approaches : abstract book. 2019;:79.
https://hdl.handle.net/21.15107/rcub_ibiss_4795 .

Tucović, Dina, Mirkov, Ivana, Kulaš, Jelena, Zeljković, Milica, Popović, Dušanka, Zolotarevski, Lidija, Đurđić, Slađana, Mutić, Jelena, Kataranovski, Milena, Popov Aleksandrov, Aleksandra, "Environmentally relevant exposure to cadmium and health risks: skin as target organ" in Immunology at the Confluence of Multidisciplinary Approaches : abstract book (2019):79,
https://hdl.handle.net/21.15107/rcub_ibiss_4795 .

TY  - JOUR
AU  - Kulaš, Jelena
AU  - Mirkov, Ivana
AU  - Tucović, Dina
AU  - Zolotarevski, Lidija
AU  - Glamočlija, Jasmina
AU  - Veljović, Katarina
AU  - Tolinački, Maja
AU  - Golić, Nataša
AU  - Kataranovski, Milena
PY  - 2019
UR  - https://www.sciencedirect.com/science/article/pii/S0171298518301001?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3165
AB  - Microbiota inhabiting mucosal tissues is involved in maintenance of their immune homeostasis. Growing body of evidence indicate that dysbiosis in gut influence immune responses at distal sites including lungs. There are also reports concerning gut involvement with pulmonary injury/inflammation in settings of respiratory viral and bacterial infections. The impact of infections with other microorganisms on gut homeostasis is not explored. In this study, the rat model of sublethal pulmonary infection with Aspergillus fumigatus was used to investigate the effect of fungal respiratory infection on gut immune-mediated homeostasis. Signs of intestinal damage, intestinal and gut-draining lymphoid tissue cytokine responses and gut bacterial microbiota diversity were examined. Intestinal injury, inflammatory cell infiltration, as well as increased levels of intestinal interferon-γ (IFN-γ) and interleukin-17 (IL-17) (as opposed to unchanged levels of anti-inflammatory cytokine IL-10) during the two-week period depict intestinal inflammation in rats with pulmonary A. fumigatus infection. It could not be ascribed to the fungus as it was not detected in the intestine of infected rats. Increased production of pro-inflammatory cytokines by major gut-draining mesenteric lymph nodes point to these lymphoid organs as places of generation of cytokine-producing cells. No changes in spleen or systemic cytokine responses was observed, showing lack of the effects of pulmonary A. fumigatus infection outside mucosal immune system. Drop of intestinal bacterial microbiota diversity (disappearance of several bacterial bands) was noted early in infection with normalization starting from day seven. From day three, appearance of new bacterial bands (unique to infected individuals, not present in controls) was seen, and some of them are pathogens. Alterations in intestinal bacterial community might have affected intestinal immune tolerance contributing to inflammation. Disruption of gut homeostasis during pulmonary infection might render gastrointestinal tract more susceptible to variety of physiological and pathological stimuli. Data which showed for the first time gut involvement with pulmonary infection with A. fumigatus provide the baseline for future studies of the impact of fungal lung infections to gut homeostasis, particularly in individuals susceptible to these infections.
T2  - Immunobiology
T2  - Immunobiology
T1  - Pulmonary Aspergillus fumigatus infection in rats affects gastrointestinal homeostasis.
IS  - 1
VL  - 224
DO  - 10.1016/j.imbio.2018.10.001
SP  - 116
EP  - 123
ER  - 

@article{
author = "Kulaš, Jelena and Mirkov, Ivana and Tucović, Dina and Zolotarevski, Lidija and Glamočlija, Jasmina and Veljović, Katarina and Tolinački, Maja and Golić, Nataša and Kataranovski, Milena",
year = "2019",
abstract = "Microbiota inhabiting mucosal tissues is involved in maintenance of their immune homeostasis. Growing body of evidence indicate that dysbiosis in gut influence immune responses at distal sites including lungs. There are also reports concerning gut involvement with pulmonary injury/inflammation in settings of respiratory viral and bacterial infections. The impact of infections with other microorganisms on gut homeostasis is not explored. In this study, the rat model of sublethal pulmonary infection with Aspergillus fumigatus was used to investigate the effect of fungal respiratory infection on gut immune-mediated homeostasis. Signs of intestinal damage, intestinal and gut-draining lymphoid tissue cytokine responses and gut bacterial microbiota diversity were examined. Intestinal injury, inflammatory cell infiltration, as well as increased levels of intestinal interferon-γ (IFN-γ) and interleukin-17 (IL-17) (as opposed to unchanged levels of anti-inflammatory cytokine IL-10) during the two-week period depict intestinal inflammation in rats with pulmonary A. fumigatus infection. It could not be ascribed to the fungus as it was not detected in the intestine of infected rats. Increased production of pro-inflammatory cytokines by major gut-draining mesenteric lymph nodes point to these lymphoid organs as places of generation of cytokine-producing cells. No changes in spleen or systemic cytokine responses was observed, showing lack of the effects of pulmonary A. fumigatus infection outside mucosal immune system. Drop of intestinal bacterial microbiota diversity (disappearance of several bacterial bands) was noted early in infection with normalization starting from day seven. From day three, appearance of new bacterial bands (unique to infected individuals, not present in controls) was seen, and some of them are pathogens. Alterations in intestinal bacterial community might have affected intestinal immune tolerance contributing to inflammation. Disruption of gut homeostasis during pulmonary infection might render gastrointestinal tract more susceptible to variety of physiological and pathological stimuli. Data which showed for the first time gut involvement with pulmonary infection with A. fumigatus provide the baseline for future studies of the impact of fungal lung infections to gut homeostasis, particularly in individuals susceptible to these infections.",
journal = "Immunobiology, Immunobiology",
title = "Pulmonary Aspergillus fumigatus infection in rats affects gastrointestinal homeostasis.",
number = "1",
volume = "224",
doi = "10.1016/j.imbio.2018.10.001",
pages = "116-123"
}

Kulaš, J., Mirkov, I., Tucović, D., Zolotarevski, L., Glamočlija, J., Veljović, K., Tolinački, M., Golić, N.,& Kataranovski, M.. (2019). Pulmonary Aspergillus fumigatus infection in rats affects gastrointestinal homeostasis.. in Immunobiology, 224(1), 116-123.
https://doi.org/10.1016/j.imbio.2018.10.001

Kulaš J, Mirkov I, Tucović D, Zolotarevski L, Glamočlija J, Veljović K, Tolinački M, Golić N, Kataranovski M. Pulmonary Aspergillus fumigatus infection in rats affects gastrointestinal homeostasis.. in Immunobiology. 2019;224(1):116-123.
doi:10.1016/j.imbio.2018.10.001 .

Kulaš, Jelena, Mirkov, Ivana, Tucović, Dina, Zolotarevski, Lidija, Glamočlija, Jasmina, Veljović, Katarina, Tolinački, Maja, Golić, Nataša, Kataranovski, Milena, "Pulmonary Aspergillus fumigatus infection in rats affects gastrointestinal homeostasis." in Immunobiology, 224, no. 1 (2019):116-123,
https://doi.org/10.1016/j.imbio.2018.10.001 . .

TY  - JOUR
AU  - Kulaš, Jelena
AU  - Ninkov, Marina
AU  - Tucović, Dina
AU  - Popov Aleksandrov, Aleksandra
AU  - Ukropina, Mirela
AU  - Cakić Milošević, Maja
AU  - Mutić, Jelena
AU  - Kataranovski, Milena
AU  - Mirkov, Ivana
PY  - 2019
UR  - http://www.besjournal.com/en/article/doi/10.3967/bes2019.068
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3470
AB  - OBJECTIVE The aim of this study is to investigate the effects of oral cadmium (Cd) ingestion on the pulmonary immune response. METHODS Determination of Cd content in lungs and histopathological evaluation of the tissue was performed in rats following 30-day oral Cd administration (5 and 50 mg/L). Antioxidant enzyme defense (superoxide dismutase and catalase), cell infiltration, and production of tumor necrosis factor (TNF) and interferon (IFN)-γ, as well as the activity of myeloperoxidase (MPO), nitric oxide (NO), and various cytokines [interleukin (IL)-1β, IL-6, IL-10, and IL-17] were investigated. RESULTS Cd caused tissue damage and cell infiltration in the lungs, and this damage was more pronounced at higher doses. Cd deposition resulted in lung inflammation characterized by a dose-dependent IL-1β increase in lung homogenates, increased TNF levels at both doses, and IL-6 stimulation at low doses with inhibition observed at higher doses. Cd exerted differential effects on lung leukocytes isolated by enzyme digestion, and these effects were characterized by a lack of change in the production of reactive oxygen and nitrogen species, an inhibition of IL-1β and TNF, and stimulation of MPO and IFN-γ. The higher capacity of Cd-exposed lung cells to respond to the opportunistic pathogen Staphylococcus epidermidis was demonstrated in vitro. CONCLUSION The potential of ingested Cd to exert both proinflammatory and immunosuppressive effects on pulmonary tissue inflammation and immune reactivity highlights the complex immunomodulatory actions of this metal.
PB  - Biomedical and Environmental Sciences
T2  - Biomedical and Environmental Sciences
T1  - Subchronic Oral Cadmium Exposure Exerts both Stimulatory and Suppressive Effects on Pulmonary Inflammation/Immune Reactivity in Rats.
IS  - 7
VL  - 32
DO  - 10.3967/bes2019.068
SP  - 508
EP  - 519
ER  - 

@article{
author = "Kulaš, Jelena and Ninkov, Marina and Tucović, Dina and Popov Aleksandrov, Aleksandra and Ukropina, Mirela and Cakić Milošević, Maja and Mutić, Jelena and Kataranovski, Milena and Mirkov, Ivana",
year = "2019",
abstract = "OBJECTIVE The aim of this study is to investigate the effects of oral cadmium (Cd) ingestion on the pulmonary immune response. METHODS Determination of Cd content in lungs and histopathological evaluation of the tissue was performed in rats following 30-day oral Cd administration (5 and 50 mg/L). Antioxidant enzyme defense (superoxide dismutase and catalase), cell infiltration, and production of tumor necrosis factor (TNF) and interferon (IFN)-γ, as well as the activity of myeloperoxidase (MPO), nitric oxide (NO), and various cytokines [interleukin (IL)-1β, IL-6, IL-10, and IL-17] were investigated. RESULTS Cd caused tissue damage and cell infiltration in the lungs, and this damage was more pronounced at higher doses. Cd deposition resulted in lung inflammation characterized by a dose-dependent IL-1β increase in lung homogenates, increased TNF levels at both doses, and IL-6 stimulation at low doses with inhibition observed at higher doses. Cd exerted differential effects on lung leukocytes isolated by enzyme digestion, and these effects were characterized by a lack of change in the production of reactive oxygen and nitrogen species, an inhibition of IL-1β and TNF, and stimulation of MPO and IFN-γ. The higher capacity of Cd-exposed lung cells to respond to the opportunistic pathogen Staphylococcus epidermidis was demonstrated in vitro. CONCLUSION The potential of ingested Cd to exert both proinflammatory and immunosuppressive effects on pulmonary tissue inflammation and immune reactivity highlights the complex immunomodulatory actions of this metal.",
publisher = "Biomedical and Environmental Sciences",
journal = "Biomedical and Environmental Sciences",
title = "Subchronic Oral Cadmium Exposure Exerts both Stimulatory and Suppressive Effects on Pulmonary Inflammation/Immune Reactivity in Rats.",
number = "7",
volume = "32",
doi = "10.3967/bes2019.068",
pages = "508-519"
}

Kulaš, J., Ninkov, M., Tucović, D., Popov Aleksandrov, A., Ukropina, M., Cakić Milošević, M., Mutić, J., Kataranovski, M.,& Mirkov, I.. (2019). Subchronic Oral Cadmium Exposure Exerts both Stimulatory and Suppressive Effects on Pulmonary Inflammation/Immune Reactivity in Rats.. in Biomedical and Environmental Sciences
Biomedical and Environmental Sciences., 32(7), 508-519.
https://doi.org/10.3967/bes2019.068

Kulaš J, Ninkov M, Tucović D, Popov Aleksandrov A, Ukropina M, Cakić Milošević M, Mutić J, Kataranovski M, Mirkov I. Subchronic Oral Cadmium Exposure Exerts both Stimulatory and Suppressive Effects on Pulmonary Inflammation/Immune Reactivity in Rats.. in Biomedical and Environmental Sciences. 2019;32(7):508-519.
doi:10.3967/bes2019.068 .

Kulaš, Jelena, Ninkov, Marina, Tucović, Dina, Popov Aleksandrov, Aleksandra, Ukropina, Mirela, Cakić Milošević, Maja, Mutić, Jelena, Kataranovski, Milena, Mirkov, Ivana, "Subchronic Oral Cadmium Exposure Exerts both Stimulatory and Suppressive Effects on Pulmonary Inflammation/Immune Reactivity in Rats." in Biomedical and Environmental Sciences, 32, no. 7 (2019):508-519,
https://doi.org/10.3967/bes2019.068 . .

TY  - CONF
AU  - Mileusnić, Dina
AU  - Popov Aleksandrov, Aleksandra
AU  - Mirkov, Ivana
AU  - Ninkov, Marina
AU  - Kulaš, Jelena
AU  - Vukojević, Vesna
AU  - Đurđić, Slađana
AU  - Mutić, Jelena
AU  - Kataranovski, Milena
PY  - 2018
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/4855
AB  - Epidemiological studies indicate a possible link between cadmium (Cd) ingested through food and various pathologies / diseases. There is no such data when it comes to skin, although the deposition of this metal in hair is used as a biomarker of human exposure. Only one study has shown the effect of orally administered Cd on wound healing, but the effects on other homeostatic skin activities, including immune, have not been investigated. In order to investigate the potential immunomodulatory effect of this heavy metal on the skin, DA strain rats were exposed to subchronic (30 days) oral intake of cadmium (in drinking water, 5 mg / l and 50 mg / l).Cd was deposited in this tissue and led to oxidative stress, judging by the increase in antioxidant enzymes (SOD and CAT), structural changes in the skin, as well as the presence / activation of innate immune cells. Higher concentrations of deposited Cd in the epidermis compared to the dermis resulted in a stress response at the epidermal cell (EC) level, manifested by increased mRNA expression for metallothioneins (MT-1 and MT-2) and decreased GSH after a higher dose of CdThis metal also led to the manifestation of signs of inflammation, judging by the increased expression of mRNA for iNOS and IL-1β and the production of NO and IL-1β, at a lower dose, and mRNA and IL-6 and TNF protein product at a higher dose. On the other hand, Cd led to increased production of the regulatory cytokine IL-10 (at higher doses). Increased IL-17 production was observed in EC cultures isolated from the skin of rats exposed to 50 mg / l, while the amount of cytokine produced further increased in EC co-culture with lymph node lymphocytes after ConA stimulation (both doses).Cd present in the skin also increased the ability of the EC to respond to the application of the contact allergen DNCB, judging by the increase in IL-6 and TNF (at both doses), while IL-1β remained unchanged. The presented results show a generally proinflammatory effect of Cd on epidermal cells and indicate the potential of orally ingested Cd to modulate immune responses in the skin.
PB  - Belgrade: Immunological Society of Serbia
C3  - Svetski dan imunologije; 2018 Apr 26; Belgrade, Serbia
T1  - Oral cadmium intake affect skin immune ractivity
T1  - Oralni unos kadmijuma utiče na imunsku reaktivnost kože
SP  - 24
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_4855
ER  - 

@conference{
author = "Mileusnić, Dina and Popov Aleksandrov, Aleksandra and Mirkov, Ivana and Ninkov, Marina and Kulaš, Jelena and Vukojević, Vesna and Đurđić, Slađana and Mutić, Jelena and Kataranovski, Milena",
year = "2018",
abstract = "Epidemiological studies indicate a possible link between cadmium (Cd) ingested through food and various pathologies / diseases. There is no such data when it comes to skin, although the deposition of this metal in hair is used as a biomarker of human exposure. Only one study has shown the effect of orally administered Cd on wound healing, but the effects on other homeostatic skin activities, including immune, have not been investigated. In order to investigate the potential immunomodulatory effect of this heavy metal on the skin, DA strain rats were exposed to subchronic (30 days) oral intake of cadmium (in drinking water, 5 mg / l and 50 mg / l).Cd was deposited in this tissue and led to oxidative stress, judging by the increase in antioxidant enzymes (SOD and CAT), structural changes in the skin, as well as the presence / activation of innate immune cells. Higher concentrations of deposited Cd in the epidermis compared to the dermis resulted in a stress response at the epidermal cell (EC) level, manifested by increased mRNA expression for metallothioneins (MT-1 and MT-2) and decreased GSH after a higher dose of CdThis metal also led to the manifestation of signs of inflammation, judging by the increased expression of mRNA for iNOS and IL-1β and the production of NO and IL-1β, at a lower dose, and mRNA and IL-6 and TNF protein product at a higher dose. On the other hand, Cd led to increased production of the regulatory cytokine IL-10 (at higher doses). Increased IL-17 production was observed in EC cultures isolated from the skin of rats exposed to 50 mg / l, while the amount of cytokine produced further increased in EC co-culture with lymph node lymphocytes after ConA stimulation (both doses).Cd present in the skin also increased the ability of the EC to respond to the application of the contact allergen DNCB, judging by the increase in IL-6 and TNF (at both doses), while IL-1β remained unchanged. The presented results show a generally proinflammatory effect of Cd on epidermal cells and indicate the potential of orally ingested Cd to modulate immune responses in the skin.",
publisher = "Belgrade: Immunological Society of Serbia",
journal = "Svetski dan imunologije; 2018 Apr 26; Belgrade, Serbia",
title = "Oral cadmium intake affect skin immune ractivity, Oralni unos kadmijuma utiče na imunsku reaktivnost kože",
pages = "24",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_4855"
}

Mileusnić, D., Popov Aleksandrov, A., Mirkov, I., Ninkov, M., Kulaš, J., Vukojević, V., Đurđić, S., Mutić, J.,& Kataranovski, M.. (2018). Oral cadmium intake affect skin immune ractivity. in Svetski dan imunologije; 2018 Apr 26; Belgrade, Serbia
Belgrade: Immunological Society of Serbia., 24.
https://hdl.handle.net/21.15107/rcub_ibiss_4855

Mileusnić D, Popov Aleksandrov A, Mirkov I, Ninkov M, Kulaš J, Vukojević V, Đurđić S, Mutić J, Kataranovski M. Oral cadmium intake affect skin immune ractivity. in Svetski dan imunologije; 2018 Apr 26; Belgrade, Serbia. 2018;:24.
https://hdl.handle.net/21.15107/rcub_ibiss_4855 .

Mileusnić, Dina, Popov Aleksandrov, Aleksandra, Mirkov, Ivana, Ninkov, Marina, Kulaš, Jelena, Vukojević, Vesna, Đurđić, Slađana, Mutić, Jelena, Kataranovski, Milena, "Oral cadmium intake affect skin immune ractivity" in Svetski dan imunologije; 2018 Apr 26; Belgrade, Serbia (2018):24,
https://hdl.handle.net/21.15107/rcub_ibiss_4855 .

TY  - JOUR
AU  - Popov Aleksandrov, Aleksandra
AU  - Belij-Rammerstorfer, Sandra
AU  - Mirkov, Ivana
AU  - Subota, Vesna
AU  - Kulaš, Jelena
AU  - Kataranovski, Dragan
AU  - Kataranovski, Milena
PY  - 2018
UR  - https://www.tandfonline.com/doi/full/10.1080/15569527.2017.1328690
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2764
AB  - Purpose: The efficacy of topical dinitrochlorobenzene (DNCB) in the treatment of some skin dermatoses is based both on local and systemic effects. It is not known, however, whether it can be applied to patients receiving some other therapy associated with systemic immunomodulation. The aim of the present paper using a rat model was to examine whether oral warfarin (WF) intake, as shown by others and by us, had an immunomodulatory potential to interfere with effects of topical DNCB as systemic immunotherapy. Materials and methods: Rats received 3.5 mg/l of WF sodium in drinking water for 30 days and were thereafter skin-sensitized with 0.4% DNCB. Changes in the oxidative activity (myeloperoxidase/MPO, reduction of nitroblue tetrazolium/NBT and nitric oxide/NO production) as well as tumor necrosis factor (TNF) production by peripheral blood polymorphonuclear cells (PMN) were measured and compared with PMN from sensitized unexposed to WF rats. Results: WF intake enhanced some aspects of PMN activity (intracellular MPO activity and unstimulated NO production) as well as their responsiveness to exogenous stimulation (NBT reduction and TNF production from sensitized animals). However, WF also decreased PMN responsiveness of NO production to stimulation. WF affected NO and TNF production solely by PMN, as no effect on these activities of peripheral blood mononuclear cells was seen. Conclusion: Having in mind that polymorphonuclear leukocytes are the most abundant cell type in peripheral blood in humans, increase of basic aspects of PMN activity described in the present paper might be relevant for consideration of using WF as therapeutic modality in patients topically treated with DNCB.
T2  - Cutaneous and Ocular Toxicology
T1  - Oral warfarin affects some aspects of systemic immunomodulation with topical dinitrochlorobenzene (DNCB) in rats
IS  - 1
VL  - 37
DO  - 10.1080/15569527.2017.1328690
SP  - 29
EP  - 35
ER  - 

@article{
author = "Popov Aleksandrov, Aleksandra and Belij-Rammerstorfer, Sandra and Mirkov, Ivana and Subota, Vesna and Kulaš, Jelena and Kataranovski, Dragan and Kataranovski, Milena",
year = "2018",
abstract = "Purpose: The efficacy of topical dinitrochlorobenzene (DNCB) in the treatment of some skin dermatoses is based both on local and systemic effects. It is not known, however, whether it can be applied to patients receiving some other therapy associated with systemic immunomodulation. The aim of the present paper using a rat model was to examine whether oral warfarin (WF) intake, as shown by others and by us, had an immunomodulatory potential to interfere with effects of topical DNCB as systemic immunotherapy. Materials and methods: Rats received 3.5 mg/l of WF sodium in drinking water for 30 days and were thereafter skin-sensitized with 0.4% DNCB. Changes in the oxidative activity (myeloperoxidase/MPO, reduction of nitroblue tetrazolium/NBT and nitric oxide/NO production) as well as tumor necrosis factor (TNF) production by peripheral blood polymorphonuclear cells (PMN) were measured and compared with PMN from sensitized unexposed to WF rats. Results: WF intake enhanced some aspects of PMN activity (intracellular MPO activity and unstimulated NO production) as well as their responsiveness to exogenous stimulation (NBT reduction and TNF production from sensitized animals). However, WF also decreased PMN responsiveness of NO production to stimulation. WF affected NO and TNF production solely by PMN, as no effect on these activities of peripheral blood mononuclear cells was seen. Conclusion: Having in mind that polymorphonuclear leukocytes are the most abundant cell type in peripheral blood in humans, increase of basic aspects of PMN activity described in the present paper might be relevant for consideration of using WF as therapeutic modality in patients topically treated with DNCB.",
journal = "Cutaneous and Ocular Toxicology",
title = "Oral warfarin affects some aspects of systemic immunomodulation with topical dinitrochlorobenzene (DNCB) in rats",
number = "1",
volume = "37",
doi = "10.1080/15569527.2017.1328690",
pages = "29-35"
}

Popov Aleksandrov, A., Belij-Rammerstorfer, S., Mirkov, I., Subota, V., Kulaš, J., Kataranovski, D.,& Kataranovski, M.. (2018). Oral warfarin affects some aspects of systemic immunomodulation with topical dinitrochlorobenzene (DNCB) in rats. in Cutaneous and Ocular Toxicology, 37(1), 29-35.
https://doi.org/10.1080/15569527.2017.1328690

Popov Aleksandrov A, Belij-Rammerstorfer S, Mirkov I, Subota V, Kulaš J, Kataranovski D, Kataranovski M. Oral warfarin affects some aspects of systemic immunomodulation with topical dinitrochlorobenzene (DNCB) in rats. in Cutaneous and Ocular Toxicology. 2018;37(1):29-35.
doi:10.1080/15569527.2017.1328690 .

Popov Aleksandrov, Aleksandra, Belij-Rammerstorfer, Sandra, Mirkov, Ivana, Subota, Vesna, Kulaš, Jelena, Kataranovski, Dragan, Kataranovski, Milena, "Oral warfarin affects some aspects of systemic immunomodulation with topical dinitrochlorobenzene (DNCB) in rats" in Cutaneous and Ocular Toxicology, 37, no. 1 (2018):29-35,
https://doi.org/10.1080/15569527.2017.1328690 . .

TY  - JOUR
AU  - Popov Aleksandrov, Aleksandra
AU  - Mirkov, Ivana
AU  - Ninkov, Marina
AU  - Tucović, Dina
AU  - Demenesku, Jelena
AU  - Subota, Vesna
AU  - Kataranovski, Dragan
AU  - Kataranovski, Milena
PY  - 2018
UR  - https://www.sciencedirect.com/science/article/pii/S027869151830019X?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2999
AB  - Warfarin is the world's most widely used anticoagulant drug. Its anticoagulant activity is based on the inhibition of the vitamin K-dependent (VKD) step in the complete synthesis of a number of blood coagulation factors that are required for normal blood coagulation. Warfarin also affects synthesis of VKD proteins not related to haemostasis including those involved in bone growth and vascular calcification. Antithrombotic activity of warfarin is considered responsible for some aspects of its anti-tumour activity of warfarin. Some aspects of activities against tumours seem not to be related to haemostasis and included effects of warfarin on non-haemostatic VKD proteins as well as those not related to VKD proteins. Inflammatory/immunomodulatory effects of warfarin indicate much broader potential of action of this drug both in physiological and pathological processes. This review provides an overview of the published data dealing with the effects of warfarin on biological processes other than haemostasis.
PB  - Pergamon
T2  - Food and Chemical Toxicology
T1  - Effects of warfarin on biological processes other than haemostasis: A review.
VL  - 113
DO  - 10.1016/j.fct.2018.01.019
SP  - 19
EP  - 32
ER  - 

@article{
author = "Popov Aleksandrov, Aleksandra and Mirkov, Ivana and Ninkov, Marina and Tucović, Dina and Demenesku, Jelena and Subota, Vesna and Kataranovski, Dragan and Kataranovski, Milena",
year = "2018",
abstract = "Warfarin is the world's most widely used anticoagulant drug. Its anticoagulant activity is based on the inhibition of the vitamin K-dependent (VKD) step in the complete synthesis of a number of blood coagulation factors that are required for normal blood coagulation. Warfarin also affects synthesis of VKD proteins not related to haemostasis including those involved in bone growth and vascular calcification. Antithrombotic activity of warfarin is considered responsible for some aspects of its anti-tumour activity of warfarin. Some aspects of activities against tumours seem not to be related to haemostasis and included effects of warfarin on non-haemostatic VKD proteins as well as those not related to VKD proteins. Inflammatory/immunomodulatory effects of warfarin indicate much broader potential of action of this drug both in physiological and pathological processes. This review provides an overview of the published data dealing with the effects of warfarin on biological processes other than haemostasis.",
publisher = "Pergamon",
journal = "Food and Chemical Toxicology",
title = "Effects of warfarin on biological processes other than haemostasis: A review.",
volume = "113",
doi = "10.1016/j.fct.2018.01.019",
pages = "19-32"
}

Popov Aleksandrov, A., Mirkov, I., Ninkov, M., Tucović, D., Demenesku, J., Subota, V., Kataranovski, D.,& Kataranovski, M.. (2018). Effects of warfarin on biological processes other than haemostasis: A review.. in Food and Chemical Toxicology
Pergamon., 113, 19-32.
https://doi.org/10.1016/j.fct.2018.01.019

Popov Aleksandrov A, Mirkov I, Ninkov M, Tucović D, Demenesku J, Subota V, Kataranovski D, Kataranovski M. Effects of warfarin on biological processes other than haemostasis: A review.. in Food and Chemical Toxicology. 2018;113:19-32.
doi:10.1016/j.fct.2018.01.019 .

Popov Aleksandrov, Aleksandra, Mirkov, Ivana, Ninkov, Marina, Tucović, Dina, Demenesku, Jelena, Subota, Vesna, Kataranovski, Dragan, Kataranovski, Milena, "Effects of warfarin on biological processes other than haemostasis: A review." in Food and Chemical Toxicology, 113 (2018):19-32,
https://doi.org/10.1016/j.fct.2018.01.019 . .

TY  - JOUR
AU  - Mirkov, Ivana
AU  - Popov Aleksandrov, Aleksandra
AU  - Subota, Vesna
AU  - Kataranovski, Dragan
AU  - Kataranovski, Milena
PY  - 2018
UR  - http://doi.wiley.com/10.1111/1749-4877.12296
UR  - http://www.ncbi.nlm.nih.gov/pubmed/29168613
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3021
AB  - Studies of wild animals' immunity often use comparison with laboratory-raised individuals. Using such an approach, various data were obtained concerning wild Norway rat's immunity. Lower or higher potential of immune system cells to respond to activation stimuli were shown, because of analysis of disparate parameters and/ or small number of analyzed individuals. Inconsistent differences between laboratory and wild rats were shown too, owing to great response variability in wild rats. We hypothesized that wild rats will express more intense immune activity compared to their laboratory counterparts which live in a less demanding environment. To test this, we analyzed the circulating levels of inflammatory cytokine interleukin-6 (IL-6), a mediator which has a central role in host immune defense. In addition, we examined the activity of the central immune organ, the spleen, including cell proliferation and production of pro-inflammatory cytokines interferon-γ (IFN-γ) and interleukin-17 (IL-17), which are major effectors of cellular adaptive immune response. In order to obtain reasonable insight into the immunity of wild Norway rats, analysis was conducted on a much larger number of individuals compared to other studies. Higher levels of plasma IL-6, higher spleen mass, cellularity and basal IFN-γ production concomitantly with lower basal production of anti-inflammatory cytokine interleukin-10 (IL-10) revealed more intense immune activity in the wild compared to laboratory rats. However, lower responsiveness of their spleen cells' proinflammatory cytokine production to concanavalin A (ConA) stimulation, along with preserved capacity of IL-10 response, might be perceived as an indication of wild rats' reduced capability to cope with incoming environmental stimuli, but also as a means to limit tissue damage.
T2  - Integrative Zoology
T1  - Immune defense of wild-caught Norway rats is characterized by increased levels of basal activity but reduced capability to respond to further immune stimulation.
IS  - 2
VL  - 13
DO  - 10.1111/1749-4877.12296
SP  - 180
EP  - 193
ER  - 

@article{
author = "Mirkov, Ivana and Popov Aleksandrov, Aleksandra and Subota, Vesna and Kataranovski, Dragan and Kataranovski, Milena",
year = "2018",
abstract = "Studies of wild animals' immunity often use comparison with laboratory-raised individuals. Using such an approach, various data were obtained concerning wild Norway rat's immunity. Lower or higher potential of immune system cells to respond to activation stimuli were shown, because of analysis of disparate parameters and/ or small number of analyzed individuals. Inconsistent differences between laboratory and wild rats were shown too, owing to great response variability in wild rats. We hypothesized that wild rats will express more intense immune activity compared to their laboratory counterparts which live in a less demanding environment. To test this, we analyzed the circulating levels of inflammatory cytokine interleukin-6 (IL-6), a mediator which has a central role in host immune defense. In addition, we examined the activity of the central immune organ, the spleen, including cell proliferation and production of pro-inflammatory cytokines interferon-γ (IFN-γ) and interleukin-17 (IL-17), which are major effectors of cellular adaptive immune response. In order to obtain reasonable insight into the immunity of wild Norway rats, analysis was conducted on a much larger number of individuals compared to other studies. Higher levels of plasma IL-6, higher spleen mass, cellularity and basal IFN-γ production concomitantly with lower basal production of anti-inflammatory cytokine interleukin-10 (IL-10) revealed more intense immune activity in the wild compared to laboratory rats. However, lower responsiveness of their spleen cells' proinflammatory cytokine production to concanavalin A (ConA) stimulation, along with preserved capacity of IL-10 response, might be perceived as an indication of wild rats' reduced capability to cope with incoming environmental stimuli, but also as a means to limit tissue damage.",
journal = "Integrative Zoology",
title = "Immune defense of wild-caught Norway rats is characterized by increased levels of basal activity but reduced capability to respond to further immune stimulation.",
number = "2",
volume = "13",
doi = "10.1111/1749-4877.12296",
pages = "180-193"
}

Mirkov, I., Popov Aleksandrov, A., Subota, V., Kataranovski, D.,& Kataranovski, M.. (2018). Immune defense of wild-caught Norway rats is characterized by increased levels of basal activity but reduced capability to respond to further immune stimulation.. in Integrative Zoology, 13(2), 180-193.
https://doi.org/10.1111/1749-4877.12296

Mirkov I, Popov Aleksandrov A, Subota V, Kataranovski D, Kataranovski M. Immune defense of wild-caught Norway rats is characterized by increased levels of basal activity but reduced capability to respond to further immune stimulation.. in Integrative Zoology. 2018;13(2):180-193.
doi:10.1111/1749-4877.12296 .

Mirkov, Ivana, Popov Aleksandrov, Aleksandra, Subota, Vesna, Kataranovski, Dragan, Kataranovski, Milena, "Immune defense of wild-caught Norway rats is characterized by increased levels of basal activity but reduced capability to respond to further immune stimulation." in Integrative Zoology, 13, no. 2 (2018):180-193,
https://doi.org/10.1111/1749-4877.12296 . .

TY  - JOUR
AU  - Tucović, Dina
AU  - Popov Aleksandrov, Aleksandra
AU  - Mirkov, Ivana
AU  - Ninkov, Marina
AU  - Kulaš, Jelena
AU  - Zolotarevski, Lidija
AU  - Vukojević, Vesna
AU  - Mutić, Jelena
AU  - Tatalović, Nikola
AU  - Kataranovski, Milena
PY  - 2018
UR  - https://www.sciencedirect.com/science/article/pii/S0147651318307231?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3126
AB  - Skin can acquire cadmium (Cd) by oral route, but there is paucity of data concerning cutaneous effects of this metal. Cd acquired by oral route can affect skin wound healing, but the effect of Cd on other activities involved in skin homeostasis, including skin immunity, are not explored. Using the rat model of 30-day oral administration of Cd (5 ppm and 50 ppm) in drinking water, basic aspects of immune-relevant activity of epidermal cells were examined. Dose-dependent Cd deposition in the the skin was observed (0.035 ± 0.02 µg/g and 0.127 ± 0.04 µg/g at 5 ppm and 50 ppm, respectively, compared to 0.012 ± 0.009 µg/g at 0 ppm of Cd). This resulted in skin inflammation (oxidative stress at both Cd doses and dose-dependent structural changes in the skin and the presence/activation of innate immunity cells). At low Cd dose inflammatory response (nitric oxide and IL-1β) was observed. Other inflammatory cytokines (IL-6 and TNF) response occurred at 50 ppm, which was increased further following skin sensitization with contact allergen dinitro-chlorobenzene (DNCB). Epidermal cells exposed to both Cd doses enhanced concanavalin A (ConA)-stimulated lymphocyte production of IL-17. This study showed for the first time the effect of the metal which gained access to the skin via gut on immune reactivity of epidermal cells. Presented data might be relevant for the link between dietary Cd and the risk of skin pathologies.
T2  - Ecotoxicology and Environmental Safety
T1  - Oral cadmium exposure affects skin immune reactivity in rats.
VL  - 164
DO  - 10.1016/j.ecoenv.2018.07.117
SP  - 12
EP  - 20
ER  - 

@article{
author = "Tucović, Dina and Popov Aleksandrov, Aleksandra and Mirkov, Ivana and Ninkov, Marina and Kulaš, Jelena and Zolotarevski, Lidija and Vukojević, Vesna and Mutić, Jelena and Tatalović, Nikola and Kataranovski, Milena",
year = "2018",
abstract = "Skin can acquire cadmium (Cd) by oral route, but there is paucity of data concerning cutaneous effects of this metal. Cd acquired by oral route can affect skin wound healing, but the effect of Cd on other activities involved in skin homeostasis, including skin immunity, are not explored. Using the rat model of 30-day oral administration of Cd (5 ppm and 50 ppm) in drinking water, basic aspects of immune-relevant activity of epidermal cells were examined. Dose-dependent Cd deposition in the the skin was observed (0.035 ± 0.02 µg/g and 0.127 ± 0.04 µg/g at 5 ppm and 50 ppm, respectively, compared to 0.012 ± 0.009 µg/g at 0 ppm of Cd). This resulted in skin inflammation (oxidative stress at both Cd doses and dose-dependent structural changes in the skin and the presence/activation of innate immunity cells). At low Cd dose inflammatory response (nitric oxide and IL-1β) was observed. Other inflammatory cytokines (IL-6 and TNF) response occurred at 50 ppm, which was increased further following skin sensitization with contact allergen dinitro-chlorobenzene (DNCB). Epidermal cells exposed to both Cd doses enhanced concanavalin A (ConA)-stimulated lymphocyte production of IL-17. This study showed for the first time the effect of the metal which gained access to the skin via gut on immune reactivity of epidermal cells. Presented data might be relevant for the link between dietary Cd and the risk of skin pathologies.",
journal = "Ecotoxicology and Environmental Safety",
title = "Oral cadmium exposure affects skin immune reactivity in rats.",
volume = "164",
doi = "10.1016/j.ecoenv.2018.07.117",
pages = "12-20"
}

Tucović, D., Popov Aleksandrov, A., Mirkov, I., Ninkov, M., Kulaš, J., Zolotarevski, L., Vukojević, V., Mutić, J., Tatalović, N.,& Kataranovski, M.. (2018). Oral cadmium exposure affects skin immune reactivity in rats.. in Ecotoxicology and Environmental Safety, 164, 12-20.
https://doi.org/10.1016/j.ecoenv.2018.07.117

Tucović D, Popov Aleksandrov A, Mirkov I, Ninkov M, Kulaš J, Zolotarevski L, Vukojević V, Mutić J, Tatalović N, Kataranovski M. Oral cadmium exposure affects skin immune reactivity in rats.. in Ecotoxicology and Environmental Safety. 2018;164:12-20.
doi:10.1016/j.ecoenv.2018.07.117 .

Tucović, Dina, Popov Aleksandrov, Aleksandra, Mirkov, Ivana, Ninkov, Marina, Kulaš, Jelena, Zolotarevski, Lidija, Vukojević, Vesna, Mutić, Jelena, Tatalović, Nikola, Kataranovski, Milena, "Oral cadmium exposure affects skin immune reactivity in rats." in Ecotoxicology and Environmental Safety, 164 (2018):12-20,
https://doi.org/10.1016/j.ecoenv.2018.07.117 . .

TY  - JOUR
AU  - Janićijević, Željko
AU  - Ninkov, Marina
AU  - Kataranovski, Milena
AU  - Radovanović, Filip
PY  - 2018
UR  - https://onlinelibrary.wiley.com/doi/abs/10.1002/mabi.201800322
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3219
AB  - Poly(DL-lactide-co-ε-caprolactone)/poly(acrylic acid) implantable composite reservoirs for cationic drugs are synthesized by sequentially applying photoirradiation and liquid phase inversion. The chemical composition and microstructure of reservoirs are characterized with Fourier transform infrared spectroscopy-attenuated total reflection (FTIR-ATR) and scanning electron microscopy (SEM), respectively. Drug loading and release properties are investigated using methylene blue as the drug model. Biocompatibility of reservoirs is examined through a series of in vitro tests and an in vivo experiment of subcutaneous implantation in Dark Agouti rats. Reservoirs show good ion-exchange capacity, high water content, and fast reversible swelling with retained geometry. Results of drug loading and release reveal excellent loading efficiency and diffusion-controlled release during 2 weeks. Biocompatibility tests in vitro demonstrate the lack of implant proinflammatory potential and hindered adhesion of L929 cells on the implant surface. Implants exhibit low acute toxicity and elicit a normal acute foreign body reaction that reaches the early stages of fibrous capsule formation after 7 days.
T2  - Macromolecular Bioscience
T1  - Poly(DL-Lactide-co-ε-Caprolactone)/Poly(Acrylic Acid) Composite Implant for Controlled Delivery of Cationic Drugs.
DO  - 10.1002/mabi.201800322
ER  - 

@article{
author = "Janićijević, Željko and Ninkov, Marina and Kataranovski, Milena and Radovanović, Filip",
year = "2018",
abstract = "Poly(DL-lactide-co-ε-caprolactone)/poly(acrylic acid) implantable composite reservoirs for cationic drugs are synthesized by sequentially applying photoirradiation and liquid phase inversion. The chemical composition and microstructure of reservoirs are characterized with Fourier transform infrared spectroscopy-attenuated total reflection (FTIR-ATR) and scanning electron microscopy (SEM), respectively. Drug loading and release properties are investigated using methylene blue as the drug model. Biocompatibility of reservoirs is examined through a series of in vitro tests and an in vivo experiment of subcutaneous implantation in Dark Agouti rats. Reservoirs show good ion-exchange capacity, high water content, and fast reversible swelling with retained geometry. Results of drug loading and release reveal excellent loading efficiency and diffusion-controlled release during 2 weeks. Biocompatibility tests in vitro demonstrate the lack of implant proinflammatory potential and hindered adhesion of L929 cells on the implant surface. Implants exhibit low acute toxicity and elicit a normal acute foreign body reaction that reaches the early stages of fibrous capsule formation after 7 days.",
journal = "Macromolecular Bioscience",
title = "Poly(DL-Lactide-co-ε-Caprolactone)/Poly(Acrylic Acid) Composite Implant for Controlled Delivery of Cationic Drugs.",
doi = "10.1002/mabi.201800322"
}

Janićijević, Ž., Ninkov, M., Kataranovski, M.,& Radovanović, F.. (2018). Poly(DL-Lactide-co-ε-Caprolactone)/Poly(Acrylic Acid) Composite Implant for Controlled Delivery of Cationic Drugs.. in Macromolecular Bioscience.
https://doi.org/10.1002/mabi.201800322

Janićijević Ž, Ninkov M, Kataranovski M, Radovanović F. Poly(DL-Lactide-co-ε-Caprolactone)/Poly(Acrylic Acid) Composite Implant for Controlled Delivery of Cationic Drugs.. in Macromolecular Bioscience. 2018;.
doi:10.1002/mabi.201800322 .

Janićijević, Željko, Ninkov, Marina, Kataranovski, Milena, Radovanović, Filip, "Poly(DL-Lactide-co-ε-Caprolactone)/Poly(Acrylic Acid) Composite Implant for Controlled Delivery of Cationic Drugs." in Macromolecular Bioscience (2018),
https://doi.org/10.1002/mabi.201800322 . .

TY  - CONF
AU  - Mirkov, Ivana
AU  - Popov Aleksandrov, Aleksandra
AU  - Ninkov, Marina
AU  - Mileusnić, Dina
AU  - Kulaš, Jelena
AU  - Jovčić, Jelena
AU  - Stefanović, Jana
AU  - Glamočlija, Jasmina
AU  - Veljović, Katarina
AU  - Kataranovski, Milena
PY  - 2017
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/4856
AB  - Our previous studies have shown poorer activity / absence of cellular immune response in AO compared to DA rats. Given the scarcity of data on innate immunity reactions in these two strains, the aim of this study was to obtain initial data on this type of immune activity. Using a model of subcutaneously implanted polyvinyl sponges, the basic aspects of neutrophil leukocyte activity important for the response to A. fumigatus were examined.Although a higher number of neutrophil leukocytes of AO rats migrate to fungal-free sponges (group K), the yield of cells from fungal sponges (group A) is the same in both strains, while CD11b cell expression is lower in both AO groups compared to DA rats. . Despite the higher oxidative activity of cells from group AO compared to DA, NBT reduction is the same (spontaneous) or lower (after stimulation with PMA) in group A compared to K in AO, and the production of myeloperoxidase (MPO) and NO is lower .In DA rats, the presence of the fungus leads to an increase in the activity of A cells in relation to group K. Molecular identification of the bacterial composition of the lung microbiota under conditions of infection with A. fumigatus established the presence of Staphylococcus epidermidis and Veillonella cavie only in AO, and Streptococcus salivarius and Propionibacterium acne only in DA rats. The presence of different doses of S. epidermidis (SE) in the sponge with A led to inhibition of MPO production in both strains. Soybean differences were observed depending on the dose of SE and / or the test activity. The lowest dose leads to inhibition of NBT reduction in AO, but stimulation in DA, while higher doses of SE stimulate the response in both strains.The low concentration of the bacterium has no effect on the production of NO in AO, but higher doses stimulate it, in contrast to the inhibition in DA at all doses of SE. The presented results indicate the existence of strain differences in the innate-immune response of rats, as well as that they may depend on the type of activity examined.
PB  - Belgrade: Immunological Society of Serbia
C3  - Svetski dan imunologije; 2017 Apr 26; Belgrade, Serbia
T1  - Influence of strain on the innate-immune reactions in rats
T1  - Uticaj soja na urođeno-imunske reakcije pacova
SP  - 18
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_4856
ER  - 

@conference{
author = "Mirkov, Ivana and Popov Aleksandrov, Aleksandra and Ninkov, Marina and Mileusnić, Dina and Kulaš, Jelena and Jovčić, Jelena and Stefanović, Jana and Glamočlija, Jasmina and Veljović, Katarina and Kataranovski, Milena",
year = "2017",
abstract = "Our previous studies have shown poorer activity / absence of cellular immune response in AO compared to DA rats. Given the scarcity of data on innate immunity reactions in these two strains, the aim of this study was to obtain initial data on this type of immune activity. Using a model of subcutaneously implanted polyvinyl sponges, the basic aspects of neutrophil leukocyte activity important for the response to A. fumigatus were examined.Although a higher number of neutrophil leukocytes of AO rats migrate to fungal-free sponges (group K), the yield of cells from fungal sponges (group A) is the same in both strains, while CD11b cell expression is lower in both AO groups compared to DA rats. . Despite the higher oxidative activity of cells from group AO compared to DA, NBT reduction is the same (spontaneous) or lower (after stimulation with PMA) in group A compared to K in AO, and the production of myeloperoxidase (MPO) and NO is lower .In DA rats, the presence of the fungus leads to an increase in the activity of A cells in relation to group K. Molecular identification of the bacterial composition of the lung microbiota under conditions of infection with A. fumigatus established the presence of Staphylococcus epidermidis and Veillonella cavie only in AO, and Streptococcus salivarius and Propionibacterium acne only in DA rats. The presence of different doses of S. epidermidis (SE) in the sponge with A led to inhibition of MPO production in both strains. Soybean differences were observed depending on the dose of SE and / or the test activity. The lowest dose leads to inhibition of NBT reduction in AO, but stimulation in DA, while higher doses of SE stimulate the response in both strains.The low concentration of the bacterium has no effect on the production of NO in AO, but higher doses stimulate it, in contrast to the inhibition in DA at all doses of SE. The presented results indicate the existence of strain differences in the innate-immune response of rats, as well as that they may depend on the type of activity examined.",
publisher = "Belgrade: Immunological Society of Serbia",
journal = "Svetski dan imunologije; 2017 Apr 26; Belgrade, Serbia",
title = "Influence of strain on the innate-immune reactions in rats, Uticaj soja na urođeno-imunske reakcije pacova",
pages = "18",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_4856"
}

Mirkov, I., Popov Aleksandrov, A., Ninkov, M., Mileusnić, D., Kulaš, J., Jovčić, J., Stefanović, J., Glamočlija, J., Veljović, K.,& Kataranovski, M.. (2017). Influence of strain on the innate-immune reactions in rats. in Svetski dan imunologije; 2017 Apr 26; Belgrade, Serbia
Belgrade: Immunological Society of Serbia., 18.
https://hdl.handle.net/21.15107/rcub_ibiss_4856

Mirkov I, Popov Aleksandrov A, Ninkov M, Mileusnić D, Kulaš J, Jovčić J, Stefanović J, Glamočlija J, Veljović K, Kataranovski M. Influence of strain on the innate-immune reactions in rats. in Svetski dan imunologije; 2017 Apr 26; Belgrade, Serbia. 2017;:18.
https://hdl.handle.net/21.15107/rcub_ibiss_4856 .

Mirkov, Ivana, Popov Aleksandrov, Aleksandra, Ninkov, Marina, Mileusnić, Dina, Kulaš, Jelena, Jovčić, Jelena, Stefanović, Jana, Glamočlija, Jasmina, Veljović, Katarina, Kataranovski, Milena, "Influence of strain on the innate-immune reactions in rats" in Svetski dan imunologije; 2017 Apr 26; Belgrade, Serbia (2017):18,
https://hdl.handle.net/21.15107/rcub_ibiss_4856 .