TY  - JOUR
AU  - Milić, Ljiljana
AU  - Karamarković, Aleksandar
AU  - Popadić, Dušan
AU  - Šijački, Ana
AU  - Grigorov, Ilijana
AU  - Milošević, Emina
AU  - Ćuk, Vladica
AU  - Pesko, Predrag
PY  - 2019
UR  - https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-019-4310-4
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3362
AB  - Objective

Peptic ulcer disease is a condition in which an important role has infection with H. pylori. The most common complication of peptic ulcer is bleeding. The presence of H. pylori triggers local and systemic cytokine signaling which may affect processes such as healing, gastric or duodenal rupture, and carcinogenesis. In this study, we examined the concentrations of IL-1β, IL-6, IL-10, TNF, TGF-β and IL-17A in serum by enzyme immunoassay and their mRNA expressions in periulcer biopsies obtained from patients with bleeding peptic ulcer by means of real-time-PCR.
Results

We have shown that pro-inflammatory IL-6 and TNF concentrations in serum were significantly higher in patients who were infected with H. pylori, while the concentrations of TGF-β and IL-17A were significantly lower compared to non-infected subjects. IL-17A expression in periulcer mucosa was significantly higher in patients who were infected with H. pylori, while the expression of other cytokines, there was no significant difference compared to non-infected controls. Considering higher serum concentrations in non-infected subjects and higher IL-17A expression in mucosal tissue of infected patients, our data support the studies that found IL-17A has protective role in eradication of H. pylori infection in infected patients.
PB  - BioMed Central Ltd.
T2  - BMC Research Notes
T1  - Altered cytokine expression in Helicobacter pylori infected patients with bleeding duodenal ulcer
VL  - 12
DO  - 10.1186/s13104-019-4310-4
SP  - 278
ER  - 

@article{
author = "Milić, Ljiljana and Karamarković, Aleksandar and Popadić, Dušan and Šijački, Ana and Grigorov, Ilijana and Milošević, Emina and Ćuk, Vladica and Pesko, Predrag",
year = "2019",
abstract = "Objective

Peptic ulcer disease is a condition in which an important role has infection with H. pylori. The most common complication of peptic ulcer is bleeding. The presence of H. pylori triggers local and systemic cytokine signaling which may affect processes such as healing, gastric or duodenal rupture, and carcinogenesis. In this study, we examined the concentrations of IL-1β, IL-6, IL-10, TNF, TGF-β and IL-17A in serum by enzyme immunoassay and their mRNA expressions in periulcer biopsies obtained from patients with bleeding peptic ulcer by means of real-time-PCR.
Results

We have shown that pro-inflammatory IL-6 and TNF concentrations in serum were significantly higher in patients who were infected with H. pylori, while the concentrations of TGF-β and IL-17A were significantly lower compared to non-infected subjects. IL-17A expression in periulcer mucosa was significantly higher in patients who were infected with H. pylori, while the expression of other cytokines, there was no significant difference compared to non-infected controls. Considering higher serum concentrations in non-infected subjects and higher IL-17A expression in mucosal tissue of infected patients, our data support the studies that found IL-17A has protective role in eradication of H. pylori infection in infected patients.",
publisher = "BioMed Central Ltd.",
journal = "BMC Research Notes",
title = "Altered cytokine expression in Helicobacter pylori infected patients with bleeding duodenal ulcer",
volume = "12",
doi = "10.1186/s13104-019-4310-4",
pages = "278"
}

Milić, L., Karamarković, A., Popadić, D., Šijački, A., Grigorov, I., Milošević, E., Ćuk, V.,& Pesko, P.. (2019). Altered cytokine expression in Helicobacter pylori infected patients with bleeding duodenal ulcer. in BMC Research Notes
BioMed Central Ltd.., 12, 278.
https://doi.org/10.1186/s13104-019-4310-4

Milić L, Karamarković A, Popadić D, Šijački A, Grigorov I, Milošević E, Ćuk V, Pesko P. Altered cytokine expression in Helicobacter pylori infected patients with bleeding duodenal ulcer. in BMC Research Notes. 2019;12:278.
doi:10.1186/s13104-019-4310-4 .

Milić, Ljiljana, Karamarković, Aleksandar, Popadić, Dušan, Šijački, Ana, Grigorov, Ilijana, Milošević, Emina, Ćuk, Vladica, Pesko, Predrag, "Altered cytokine expression in Helicobacter pylori infected patients with bleeding duodenal ulcer" in BMC Research Notes, 12 (2019):278,
https://doi.org/10.1186/s13104-019-4310-4 . .

TY  - JOUR
AU  - Stanisavljević, Suzana
AU  - Dinić, Miroslav
AU  - Jevtić, Bojan
AU  - Nikolovski, Neda
AU  - Momčilović, Miljana
AU  - Đokić, Jelena
AU  - Golić, Nataša
AU  - Mostarica Stojković, Marija
AU  - Miljković, Đorđe
PY  - 2018
UR  - http://journal.frontiersin.org/article/10.3389/fimmu.2018.00942/full
UR  - http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC5942155
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3056
AB  - Albino Oxford (AO) rats are extremely resistant to induction of experimental autoimmune encephalomyelitis (EAE). EAE is an animal model of multiple sclerosis, a chronic inflammatory disease of the central nervous system (CNS), with established autoimmune pathogenesis. The autoimmune response against the antigens of the CNS is initiated in the peripheral lymphoid tissues after immunization of AO rats with CNS antigens. Subsequently, limited infiltration of the CNS occurs, yet without clinical sequels. It has recently become increasingly appreciated that gut-associated lymphoid tissues (GALT) and gut microbiota play an important role in regulation and propagation of encephalitogenic immune response. Therefore, modulation of AO gut microbiota by antibiotics was performed in this study. The treatment altered composition of gut microbiota in AO rats and led to a reduction in the proportion of regulatory T cells in Peyer's patches, mesenteric lymph nodes, and in lymph nodes draining the site of immunization. Upregulation of interferon-γ and interleukin (IL)-17 production was observed in the draining lymph nodes. The treatment led to clinically manifested EAE in AO rats with more numerous infiltrates and higher production of IL-17 observed in the CNS. Importantly, transfer of AO gut microbiota into EAE-prone Dark Agouti rats ameliorated the disease. These results clearly imply that gut microbiota is an important factor in AO rat resistance to EAE and that gut microbiota transfer is an efficacious way to treat CNS autoimmunity. These findings also support the idea that gut microbiota modulation has a potential as a future treatment of multiple sclerosis.
T2  - Frontiers in Immunology
T1  - Gut Microbiota Confers Resistance of Albino Oxford Rats to the Induction of Experimental Autoimmune Encephalomyelitis.
VL  - 9
DO  - 10.3389/fimmu.2018.00942
SP  - 942
ER  - 

@article{
author = "Stanisavljević, Suzana and Dinić, Miroslav and Jevtić, Bojan and Nikolovski, Neda and Momčilović, Miljana and Đokić, Jelena and Golić, Nataša and Mostarica Stojković, Marija and Miljković, Đorđe",
year = "2018",
abstract = "Albino Oxford (AO) rats are extremely resistant to induction of experimental autoimmune encephalomyelitis (EAE). EAE is an animal model of multiple sclerosis, a chronic inflammatory disease of the central nervous system (CNS), with established autoimmune pathogenesis. The autoimmune response against the antigens of the CNS is initiated in the peripheral lymphoid tissues after immunization of AO rats with CNS antigens. Subsequently, limited infiltration of the CNS occurs, yet without clinical sequels. It has recently become increasingly appreciated that gut-associated lymphoid tissues (GALT) and gut microbiota play an important role in regulation and propagation of encephalitogenic immune response. Therefore, modulation of AO gut microbiota by antibiotics was performed in this study. The treatment altered composition of gut microbiota in AO rats and led to a reduction in the proportion of regulatory T cells in Peyer's patches, mesenteric lymph nodes, and in lymph nodes draining the site of immunization. Upregulation of interferon-γ and interleukin (IL)-17 production was observed in the draining lymph nodes. The treatment led to clinically manifested EAE in AO rats with more numerous infiltrates and higher production of IL-17 observed in the CNS. Importantly, transfer of AO gut microbiota into EAE-prone Dark Agouti rats ameliorated the disease. These results clearly imply that gut microbiota is an important factor in AO rat resistance to EAE and that gut microbiota transfer is an efficacious way to treat CNS autoimmunity. These findings also support the idea that gut microbiota modulation has a potential as a future treatment of multiple sclerosis.",
journal = "Frontiers in Immunology",
title = "Gut Microbiota Confers Resistance of Albino Oxford Rats to the Induction of Experimental Autoimmune Encephalomyelitis.",
volume = "9",
doi = "10.3389/fimmu.2018.00942",
pages = "942"
}

Stanisavljević, S., Dinić, M., Jevtić, B., Nikolovski, N., Momčilović, M., Đokić, J., Golić, N., Mostarica Stojković, M.,& Miljković, Đ.. (2018). Gut Microbiota Confers Resistance of Albino Oxford Rats to the Induction of Experimental Autoimmune Encephalomyelitis.. in Frontiers in Immunology, 9, 942.
https://doi.org/10.3389/fimmu.2018.00942

Stanisavljević S, Dinić M, Jevtić B, Nikolovski N, Momčilović M, Đokić J, Golić N, Mostarica Stojković M, Miljković Đ. Gut Microbiota Confers Resistance of Albino Oxford Rats to the Induction of Experimental Autoimmune Encephalomyelitis.. in Frontiers in Immunology. 2018;9:942.
doi:10.3389/fimmu.2018.00942 .

Stanisavljević, Suzana, Dinić, Miroslav, Jevtić, Bojan, Nikolovski, Neda, Momčilović, Miljana, Đokić, Jelena, Golić, Nataša, Mostarica Stojković, Marija, Miljković, Đorđe, "Gut Microbiota Confers Resistance of Albino Oxford Rats to the Induction of Experimental Autoimmune Encephalomyelitis." in Frontiers in Immunology, 9 (2018):942,
https://doi.org/10.3389/fimmu.2018.00942 . .

TY  - JOUR
AU  - Paunović, Verica
AU  - Vukovič Petrović, Irena
AU  - Milenković, Marina
AU  - Janjetović, Kristina
AU  - Pravica, Vera
AU  - Dujmović, Irena
AU  - Milošević, Emina
AU  - Martinović, Vanja
AU  - Mesaroš, Šarlota
AU  - Drulović, Jelena
AU  - Trajković, Vladimir
PY  - 2018
UR  - http://www.jni-journal.com/article/S0165-5728(17)30538-6/abstract
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3014
AB  - Autophagy, a process of controlled self-digestion which regulates cell homeostasis, is involved in innate and adaptive immunity. We investigated the expression of autophagy genes and autophagic activity in distinct lymphocyte populations in treatment-naive MS patients. The mRNA and protein levels of autophagy-related (ATG)5, required for autophagosome formation, were increased in CD4+and CD4-T cells, but not B cells of MS patients compared to control subjects. The expression of other investigated autophagy genes, as well as the autophagic activity, did not significantly differ between the two groups. ATG5 mRNA levels in CD4+T cells from MS patients were positively correlated with those of the proinflammatory cytokine tumor necrosis factor. These data suggest that autophagy-independent increase in ATG5 expression might be associated with the proinflammatory capacity of T cells in multiple sclerosis.
T2  - Journal of Neuroimmunology
T1  - Autophagy-independent increase of ATG5 expression in T cells of multiple sclerosis patients.
VL  - 319
DO  - 10.1016/j.jneuroim.2018.03.001
SP  - 100
EP  - 105
ER  - 

@article{
author = "Paunović, Verica and Vukovič Petrović, Irena and Milenković, Marina and Janjetović, Kristina and Pravica, Vera and Dujmović, Irena and Milošević, Emina and Martinović, Vanja and Mesaroš, Šarlota and Drulović, Jelena and Trajković, Vladimir",
year = "2018",
abstract = "Autophagy, a process of controlled self-digestion which regulates cell homeostasis, is involved in innate and adaptive immunity. We investigated the expression of autophagy genes and autophagic activity in distinct lymphocyte populations in treatment-naive MS patients. The mRNA and protein levels of autophagy-related (ATG)5, required for autophagosome formation, were increased in CD4+and CD4-T cells, but not B cells of MS patients compared to control subjects. The expression of other investigated autophagy genes, as well as the autophagic activity, did not significantly differ between the two groups. ATG5 mRNA levels in CD4+T cells from MS patients were positively correlated with those of the proinflammatory cytokine tumor necrosis factor. These data suggest that autophagy-independent increase in ATG5 expression might be associated with the proinflammatory capacity of T cells in multiple sclerosis.",
journal = "Journal of Neuroimmunology",
title = "Autophagy-independent increase of ATG5 expression in T cells of multiple sclerosis patients.",
volume = "319",
doi = "10.1016/j.jneuroim.2018.03.001",
pages = "100-105"
}

Paunović, V., Vukovič Petrović, I., Milenković, M., Janjetović, K., Pravica, V., Dujmović, I., Milošević, E., Martinović, V., Mesaroš, Š., Drulović, J.,& Trajković, V.. (2018). Autophagy-independent increase of ATG5 expression in T cells of multiple sclerosis patients.. in Journal of Neuroimmunology, 319, 100-105.
https://doi.org/10.1016/j.jneuroim.2018.03.001

Paunović V, Vukovič Petrović I, Milenković M, Janjetović K, Pravica V, Dujmović I, Milošević E, Martinović V, Mesaroš Š, Drulović J, Trajković V. Autophagy-independent increase of ATG5 expression in T cells of multiple sclerosis patients.. in Journal of Neuroimmunology. 2018;319:100-105.
doi:10.1016/j.jneuroim.2018.03.001 .

Paunović, Verica, Vukovič Petrović, Irena, Milenković, Marina, Janjetović, Kristina, Pravica, Vera, Dujmović, Irena, Milošević, Emina, Martinović, Vanja, Mesaroš, Šarlota, Drulović, Jelena, Trajković, Vladimir, "Autophagy-independent increase of ATG5 expression in T cells of multiple sclerosis patients." in Journal of Neuroimmunology, 319 (2018):100-105,
https://doi.org/10.1016/j.jneuroim.2018.03.001 . .

TY  - JOUR
AU  - Stanisavljević, Suzana
AU  - Lukić, Jovanka
AU  - Momčilović, Miljana
AU  - Miljković, Marija
AU  - Jevtić, Bojan
AU  - Kojić, Milan
AU  - Golić, Nataša
AU  - Mostarica Stojković, Marija
AU  - Miljković, Đorđe
PY  - 2016
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6049
AB  - Gut microbiota and gut-associated lymphoid tissue have been increasingly appreciated as important players in pathogenesis of various autoimmune diseases, including multiple sclerosis. Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis that can be induced with an injection of spinal cord homogenate emulsified in complete Freund's adjuvant in Dark Agouti (DA) rats, but not in Albino Oxford (AO) rats. In this study, mesenteric lymph nodes (MLN), Peyer's patches (PP) and gut microbiota were analysed in these two rat strains. There was higher proportion of CD4(+) T cells and regulatory T cells in non-immunised DA rats in comparison to AO rats. Also, DA rat MLN and PP cells were higher producers of pro-inflammatory cytokines interferon-γ and interleukin-17. Finally, microbial analyses showed that uncultivated species of Turicibacter and Atopostipes genus were exclusively present in AO rats, in faeces and intestinal tissue, respectively. Thus, it is clear that in comparison of an EAE-susceptible with an EAE-resistant strain of rats, various discrepancies at the level of gut associated lymphoid tissue, as well as at the level of gut microbiota can be observed. Future studies should determine if the differences have functional significance for EAE pathogenesis.
PB  - Wageningen Academic Publishers
T2  - Beneficial Microbes
T1  - Gut-associated lymphoid tissue, gut microbes and susceptibility to experimental autoimmune encephalomyelitis
IS  - 3
VL  - 7
DO  - 10.3920/BM2015.0159
SP  - 363
EP  - 373
ER  - 

@article{
author = "Stanisavljević, Suzana and Lukić, Jovanka and Momčilović, Miljana and Miljković, Marija and Jevtić, Bojan and Kojić, Milan and Golić, Nataša and Mostarica Stojković, Marija and Miljković, Đorđe",
year = "2016",
abstract = "Gut microbiota and gut-associated lymphoid tissue have been increasingly appreciated as important players in pathogenesis of various autoimmune diseases, including multiple sclerosis. Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis that can be induced with an injection of spinal cord homogenate emulsified in complete Freund's adjuvant in Dark Agouti (DA) rats, but not in Albino Oxford (AO) rats. In this study, mesenteric lymph nodes (MLN), Peyer's patches (PP) and gut microbiota were analysed in these two rat strains. There was higher proportion of CD4(+) T cells and regulatory T cells in non-immunised DA rats in comparison to AO rats. Also, DA rat MLN and PP cells were higher producers of pro-inflammatory cytokines interferon-γ and interleukin-17. Finally, microbial analyses showed that uncultivated species of Turicibacter and Atopostipes genus were exclusively present in AO rats, in faeces and intestinal tissue, respectively. Thus, it is clear that in comparison of an EAE-susceptible with an EAE-resistant strain of rats, various discrepancies at the level of gut associated lymphoid tissue, as well as at the level of gut microbiota can be observed. Future studies should determine if the differences have functional significance for EAE pathogenesis.",
publisher = "Wageningen Academic Publishers",
journal = "Beneficial Microbes",
title = "Gut-associated lymphoid tissue, gut microbes and susceptibility to experimental autoimmune encephalomyelitis",
number = "3",
volume = "7",
doi = "10.3920/BM2015.0159",
pages = "363-373"
}

Stanisavljević, S., Lukić, J., Momčilović, M., Miljković, M., Jevtić, B., Kojić, M., Golić, N., Mostarica Stojković, M.,& Miljković, Đ.. (2016). Gut-associated lymphoid tissue, gut microbes and susceptibility to experimental autoimmune encephalomyelitis. in Beneficial Microbes
Wageningen Academic Publishers., 7(3), 363-373.
https://doi.org/10.3920/BM2015.0159

Stanisavljević S, Lukić J, Momčilović M, Miljković M, Jevtić B, Kojić M, Golić N, Mostarica Stojković M, Miljković Đ. Gut-associated lymphoid tissue, gut microbes and susceptibility to experimental autoimmune encephalomyelitis. in Beneficial Microbes. 2016;7(3):363-373.
doi:10.3920/BM2015.0159 .

Stanisavljević, Suzana, Lukić, Jovanka, Momčilović, Miljana, Miljković, Marija, Jevtić, Bojan, Kojić, Milan, Golić, Nataša, Mostarica Stojković, Marija, Miljković, Đorđe, "Gut-associated lymphoid tissue, gut microbes and susceptibility to experimental autoimmune encephalomyelitis" in Beneficial Microbes, 7, no. 3 (2016):363-373,
https://doi.org/10.3920/BM2015.0159 . .

TY  - JOUR
AU  - Stanisavljević, Suzana
AU  - Lukić, Jovanka
AU  - Soković, Svetlana
AU  - Mihajlović, Sanja
AU  - Mostarica Stojković, Marija
AU  - Miljković, Đorđe
AU  - Golić, Nataša
PY  - 2016
UR  - http://journal.frontiersin.org/article/10.3389/fmicb.2016.02005/full
UR  - https://www.scopus.com/record/display.uri?eid=2-s2.0-85008932586&origin=SingleRecordEmailAlert&dgcid=scalert_sc_search_email&txGid=4EB499CE54E80575D67A4CAC3995163A.wsnAw8kcdt7IPYLO0V48gA%3A1
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2513
AB  - Multiple sclerosis is a chronic inflammatory disease of the central nervous system (CNS). It is widely accepted that autoimmune response against the antigens of the CNS is the essential pathogenic force in the disease. It has recently become increasingly appreciated that activated encephalitogenic cells tend to migrate toward gut associated lymphoid tissues (GALTs) and that interrupted balance between regulatory and inflammatory immunity within the GALT might have decisive role in the initiation and propagation of the CNS autoimmunity. Gut microbiota composition and function has the major impact on the balance in the GALT. Thus, our aim was to perform analyses of gut microbiota in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. Albino Oxford (AO) rats that are highly resistant to EAE induction and Dark Agouti (DA) rats that develop EAE after mild immunization were compared for gut microbiota composition in different phases after EAE induction. Microbial analyses of the genus Lactobacillus and related lactic acid bacteria showed higher diversity of Lactobacillus spp. in EAE-resistant AO rats, while some members of Firmicutes and Proteobacteria (Undibacterium oligocarboniphilum) were detected only in feces of DA rats at the peak of the disease (between 13 and 16 days after induction). Interestingly, in contrast to our previous study where Turicibacter sp. was found exclusively in non-immunized AO, but not in DA rats, in this study it was detected in DA rats that remained healthy 16 days after induction, as well as in four of 12 DA rats at the peak of the disease. Similar observation was obtained for the members of Lachnospiraceae. Further, production of a typical regulatory cytokine interleukin-10 was compared in GALT cells of AO and DA rats, and higher production was observed in DA rats. Our data contribute to the idea that gut microbiota and GALT considerably influence multiple sclerosis pathogenesis.
T2  - Frontiers in Microbiology
T1  - Correlation of Gut Microbiota Composition with Resistance to Experimental Autoimmune Encephalomyelitis in Rats
VL  - 7
DO  - 10.3389/fmicb.2016.02005
SP  - 2005
EP  - 2005
ER  - 

@article{
author = "Stanisavljević, Suzana and Lukić, Jovanka and Soković, Svetlana and Mihajlović, Sanja and Mostarica Stojković, Marija and Miljković, Đorđe and Golić, Nataša",
year = "2016",
abstract = "Multiple sclerosis is a chronic inflammatory disease of the central nervous system (CNS). It is widely accepted that autoimmune response against the antigens of the CNS is the essential pathogenic force in the disease. It has recently become increasingly appreciated that activated encephalitogenic cells tend to migrate toward gut associated lymphoid tissues (GALTs) and that interrupted balance between regulatory and inflammatory immunity within the GALT might have decisive role in the initiation and propagation of the CNS autoimmunity. Gut microbiota composition and function has the major impact on the balance in the GALT. Thus, our aim was to perform analyses of gut microbiota in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. Albino Oxford (AO) rats that are highly resistant to EAE induction and Dark Agouti (DA) rats that develop EAE after mild immunization were compared for gut microbiota composition in different phases after EAE induction. Microbial analyses of the genus Lactobacillus and related lactic acid bacteria showed higher diversity of Lactobacillus spp. in EAE-resistant AO rats, while some members of Firmicutes and Proteobacteria (Undibacterium oligocarboniphilum) were detected only in feces of DA rats at the peak of the disease (between 13 and 16 days after induction). Interestingly, in contrast to our previous study where Turicibacter sp. was found exclusively in non-immunized AO, but not in DA rats, in this study it was detected in DA rats that remained healthy 16 days after induction, as well as in four of 12 DA rats at the peak of the disease. Similar observation was obtained for the members of Lachnospiraceae. Further, production of a typical regulatory cytokine interleukin-10 was compared in GALT cells of AO and DA rats, and higher production was observed in DA rats. Our data contribute to the idea that gut microbiota and GALT considerably influence multiple sclerosis pathogenesis.",
journal = "Frontiers in Microbiology",
title = "Correlation of Gut Microbiota Composition with Resistance to Experimental Autoimmune Encephalomyelitis in Rats",
volume = "7",
doi = "10.3389/fmicb.2016.02005",
pages = "2005-2005"
}

Stanisavljević, S., Lukić, J., Soković, S., Mihajlović, S., Mostarica Stojković, M., Miljković, Đ.,& Golić, N.. (2016). Correlation of Gut Microbiota Composition with Resistance to Experimental Autoimmune Encephalomyelitis in Rats. in Frontiers in Microbiology, 7, 2005-2005.
https://doi.org/10.3389/fmicb.2016.02005

Stanisavljević S, Lukić J, Soković S, Mihajlović S, Mostarica Stojković M, Miljković Đ, Golić N. Correlation of Gut Microbiota Composition with Resistance to Experimental Autoimmune Encephalomyelitis in Rats. in Frontiers in Microbiology. 2016;7:2005-2005.
doi:10.3389/fmicb.2016.02005 .

Stanisavljević, Suzana, Lukić, Jovanka, Soković, Svetlana, Mihajlović, Sanja, Mostarica Stojković, Marija, Miljković, Đorđe, Golić, Nataša, "Correlation of Gut Microbiota Composition with Resistance to Experimental Autoimmune Encephalomyelitis in Rats" in Frontiers in Microbiology, 7 (2016):2005-2005,
https://doi.org/10.3389/fmicb.2016.02005 . .

TY  - JOUR
AU  - Petković, Filip
AU  - Živanović, Jasmina
AU  - Blaževski, Jana
AU  - Timotijević, G.
AU  - Momčilović, Miljana
AU  - Stanojević, Ž.
AU  - Stamenković, V.
AU  - Milošević, Verica
AU  - Stojković, M. Mostarica
AU  - Miljković, Đorđe
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1968
AB  - Experimental autoimmune encephalomyelitis (EAE) is a model of multiple
   sclerosis (MS), inflammatory, demyelinating and neurodegenerative
   disease of the central nervous system (CNS). Clinically manifested EAE
   can be induced in Dark Agouti (DA) rats, but not in Albino Oxford (AO)
   rats by immunization with spinal cord homogenate (SCH) and complete
   Freund's adjuvant (CFA). Matrix metalloproteinases (MMP) play important
   roles in various steps of MS and EAE pathogenesis. Expression of
   gelatinases MMP2 and MMP9, their activator MMP14 and their inhibitor
   tissue inhibitor of MMP (TIMP) 1 in the CNS of AO and DA rats immunized
   with SCH + CFA was determined. Expression of mRNA for MMP2, MMP9 and
   MMP14 was higher and expression of TIMP1 mRNA was lower in AO rats.
   However, gelatinase activity in spinal cords was higher in samples
   obtained from DA rats. Further, while there was no strain difference in
   MMP2 and MMP9 mRNA expression in lymph nodes of the immunized rats,
   gelatinase activity was higher in DA rats. This activity was reduced by
   antiinflammatory cytokines interleukin (IL)-10 and IL-4. Interestingly,
   gelatinase activity was detected in the nuclei of cells within the CNS,
   but not of those in lymph nodes. Our results imply that
   posttranscriptional regulation of MMP2 and MMP9 expression and/or
   function determines low gelatinase activity within the CNS and in immune
   cells of EAE-resistant AO rats. (C) 2015 IBRO. Published by Elsevier
   Ltd. All rights reserved.
T2  - Neuroscience
T1  - Activity, but not mRNA expression of gelatinases correlates with susceptibility to experimental autoimmune encephalomyelitis
VL  - 292
DO  - 10.1016/j.neuroscience.2015.02.015
SP  - 1
EP  - 12
ER  - 

@article{
author = "Petković, Filip and Živanović, Jasmina and Blaževski, Jana and Timotijević, G. and Momčilović, Miljana and Stanojević, Ž. and Stamenković, V. and Milošević, Verica and Stojković, M. Mostarica and Miljković, Đorđe",
year = "2015",
abstract = "Experimental autoimmune encephalomyelitis (EAE) is a model of multiple
   sclerosis (MS), inflammatory, demyelinating and neurodegenerative
   disease of the central nervous system (CNS). Clinically manifested EAE
   can be induced in Dark Agouti (DA) rats, but not in Albino Oxford (AO)
   rats by immunization with spinal cord homogenate (SCH) and complete
   Freund's adjuvant (CFA). Matrix metalloproteinases (MMP) play important
   roles in various steps of MS and EAE pathogenesis. Expression of
   gelatinases MMP2 and MMP9, their activator MMP14 and their inhibitor
   tissue inhibitor of MMP (TIMP) 1 in the CNS of AO and DA rats immunized
   with SCH + CFA was determined. Expression of mRNA for MMP2, MMP9 and
   MMP14 was higher and expression of TIMP1 mRNA was lower in AO rats.
   However, gelatinase activity in spinal cords was higher in samples
   obtained from DA rats. Further, while there was no strain difference in
   MMP2 and MMP9 mRNA expression in lymph nodes of the immunized rats,
   gelatinase activity was higher in DA rats. This activity was reduced by
   antiinflammatory cytokines interleukin (IL)-10 and IL-4. Interestingly,
   gelatinase activity was detected in the nuclei of cells within the CNS,
   but not of those in lymph nodes. Our results imply that
   posttranscriptional regulation of MMP2 and MMP9 expression and/or
   function determines low gelatinase activity within the CNS and in immune
   cells of EAE-resistant AO rats. (C) 2015 IBRO. Published by Elsevier
   Ltd. All rights reserved.",
journal = "Neuroscience",
title = "Activity, but not mRNA expression of gelatinases correlates with susceptibility to experimental autoimmune encephalomyelitis",
volume = "292",
doi = "10.1016/j.neuroscience.2015.02.015",
pages = "1-12"
}

Petković, F., Živanović, J., Blaževski, J., Timotijević, G., Momčilović, M., Stanojević, Ž., Stamenković, V., Milošević, V., Stojković, M. M.,& Miljković, Đ.. (2015). Activity, but not mRNA expression of gelatinases correlates with susceptibility to experimental autoimmune encephalomyelitis. in Neuroscience, 292, 1-12.
https://doi.org/10.1016/j.neuroscience.2015.02.015

Petković F, Živanović J, Blaževski J, Timotijević G, Momčilović M, Stanojević Ž, Stamenković V, Milošević V, Stojković MM, Miljković Đ. Activity, but not mRNA expression of gelatinases correlates with susceptibility to experimental autoimmune encephalomyelitis. in Neuroscience. 2015;292:1-12.
doi:10.1016/j.neuroscience.2015.02.015 .

Petković, Filip, Živanović, Jasmina, Blaževski, Jana, Timotijević, G., Momčilović, Miljana, Stanojević, Ž., Stamenković, V., Milošević, Verica, Stojković, M. Mostarica, Miljković, Đorđe, "Activity, but not mRNA expression of gelatinases correlates with susceptibility to experimental autoimmune encephalomyelitis" in Neuroscience, 292 (2015):1-12,
https://doi.org/10.1016/j.neuroscience.2015.02.015 . .