TY  - JOUR
AU  - Milutinović, Milena G.
AU  - Maksimović, Vuk M.
AU  - Cvetković, Danijela M.
AU  - Nikodijević, Danijela D.
AU  - Stanković, Milan S.
AU  - Pešić, Milica
AU  - Marković, Snežana D.
PY  - 2019
UR  - https://www.sciencedirect.com/science/article/pii/S0378874119303010?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3406
AB  - ETHNOPHARMACOLOGICAL RELEVANCE Teucrum chamaedrys L. is one of the known medicinal plants, useful for treatment of various health problems, especially digestive. In this study, we investigated methanol, ethyl-acetate and acetone extracts of T. chamaedrys in respect to their anticancer properties in SW480 colorectal cancer cells. MATERIALS AND METHODS Cytotoxicity and proapoptotic potential were assessed by MTT cell viability assay and AO/EB double staining. Molecular mechanisms of induced apoptosis were determined by monitoring Fas receptor protein expression through immunofluorescence, Caspase 8 and 9 activity, as well as concentrations of O2.- spectrophotometrically. Additionally, mRNA expression of biotransformation enzymes (CYP1A1, CYP1B1, GSTP1) and membrane transporters (MRP1 and MRP2) involved in drug resistance were investigated by qPCR method. Qualitative analysis of individual phenolic compounds was performed by reversed phase HPLC-MS analysis. RESULTS Methanol extract shows the best cytotoxicity and selectivity compared to ethyl-acetate and acetone extracts, mainly causing apoptosis of SW480 cells, without affecting normal HaCaT keratinocytes. The increased expression of Fas receptor protein and caspase 8 activity indicate that the death receptor-mediated pathway plays a crucial role in the observed apoptosis. The increased caspase 9 activity and O2.- concentration suggest that mitochondria are also involved in the apoptosis. T. chamaedrys methanol extract inhibits mRNA expression of CYP1A1, CYP1B1, GSTP1, MRP1 and MRP2 in SW480 cells. CONCLUSIONS Induction of apoptosis and inhibition of CYP1A1, CYP1B1, GSTP1, MRP1 and MRP2 mRNA expression implies that T. chamaedrys can serve as a valuable source of bioactive compounds as dietary supplements or selective anticancer agents, with the ability to induce apoptosis and modulate drug resistance in colorectal cancer cells.
T2  - Journal of Ethnopharmacology
T1  - Potential of Teucrium chamaedrys L. to modulate apoptosis and biotransformation in colorectal carcinoma cells.
VL  - 240
DO  - 10.1016/j.jep.2019.111951
SP  - 111951
ER  - 

@article{
author = "Milutinović, Milena G. and Maksimović, Vuk M. and Cvetković, Danijela M. and Nikodijević, Danijela D. and Stanković, Milan S. and Pešić, Milica and Marković, Snežana D.",
year = "2019",
abstract = "ETHNOPHARMACOLOGICAL RELEVANCE Teucrum chamaedrys L. is one of the known medicinal plants, useful for treatment of various health problems, especially digestive. In this study, we investigated methanol, ethyl-acetate and acetone extracts of T. chamaedrys in respect to their anticancer properties in SW480 colorectal cancer cells. MATERIALS AND METHODS Cytotoxicity and proapoptotic potential were assessed by MTT cell viability assay and AO/EB double staining. Molecular mechanisms of induced apoptosis were determined by monitoring Fas receptor protein expression through immunofluorescence, Caspase 8 and 9 activity, as well as concentrations of O2.- spectrophotometrically. Additionally, mRNA expression of biotransformation enzymes (CYP1A1, CYP1B1, GSTP1) and membrane transporters (MRP1 and MRP2) involved in drug resistance were investigated by qPCR method. Qualitative analysis of individual phenolic compounds was performed by reversed phase HPLC-MS analysis. RESULTS Methanol extract shows the best cytotoxicity and selectivity compared to ethyl-acetate and acetone extracts, mainly causing apoptosis of SW480 cells, without affecting normal HaCaT keratinocytes. The increased expression of Fas receptor protein and caspase 8 activity indicate that the death receptor-mediated pathway plays a crucial role in the observed apoptosis. The increased caspase 9 activity and O2.- concentration suggest that mitochondria are also involved in the apoptosis. T. chamaedrys methanol extract inhibits mRNA expression of CYP1A1, CYP1B1, GSTP1, MRP1 and MRP2 in SW480 cells. CONCLUSIONS Induction of apoptosis and inhibition of CYP1A1, CYP1B1, GSTP1, MRP1 and MRP2 mRNA expression implies that T. chamaedrys can serve as a valuable source of bioactive compounds as dietary supplements or selective anticancer agents, with the ability to induce apoptosis and modulate drug resistance in colorectal cancer cells.",
journal = "Journal of Ethnopharmacology",
title = "Potential of Teucrium chamaedrys L. to modulate apoptosis and biotransformation in colorectal carcinoma cells.",
volume = "240",
doi = "10.1016/j.jep.2019.111951",
pages = "111951"
}

Milutinović, M. G., Maksimović, V. M., Cvetković, D. M., Nikodijević, D. D., Stanković, M. S., Pešić, M.,& Marković, S. D.. (2019). Potential of Teucrium chamaedrys L. to modulate apoptosis and biotransformation in colorectal carcinoma cells.. in Journal of Ethnopharmacology, 240, 111951.
https://doi.org/10.1016/j.jep.2019.111951

Milutinović MG, Maksimović VM, Cvetković DM, Nikodijević DD, Stanković MS, Pešić M, Marković SD. Potential of Teucrium chamaedrys L. to modulate apoptosis and biotransformation in colorectal carcinoma cells.. in Journal of Ethnopharmacology. 2019;240:111951.
doi:10.1016/j.jep.2019.111951 .

Milutinović, Milena G., Maksimović, Vuk M., Cvetković, Danijela M., Nikodijević, Danijela D., Stanković, Milan S., Pešić, Milica, Marković, Snežana D., "Potential of Teucrium chamaedrys L. to modulate apoptosis and biotransformation in colorectal carcinoma cells." in Journal of Ethnopharmacology, 240 (2019):111951,
https://doi.org/10.1016/j.jep.2019.111951 . .

TY  - JOUR
AU  - Trbojević, Ivana S.
AU  - Ognjanović, Branka I.
AU  - Đorđević, Nataša Z.
AU  - Marković, Snežana D.
AU  - Štajn, A.Š.
AU  - Gavrić, Jelena
AU  - Saičić, Zorica
PY  - 2010
PY  - 2010
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/246
AB  - The role of oxidative stress in cisplatin (CP) toxicity and its prevention by pretreatment with selenium (Se) was investigated. Male Wistar albino rats were injected with a single dose of cisplatin (7.5 mg CP/kg b.m., i.p.) and selenium (6 mg Se/kg b.m, as Na2SeO3, i.p.) alone or in combination. The results suggest that CP intoxication induces oxidative stress and alters the glutathione redox status: reduced glutathione (GSH), oxidized glutathione (GSSG) and the GSH/GSSG ratio (GSH RI), resulting in increased lipid peroxidation (LPO) in rat liver. The pretreatment with selenium prior to CP treatment showed a protective effect against the toxic influence of CP on peroxidation of the membrane lipids and an altering of the glutathione redox status in the liver of rats. From our results we conclude that selenium functions as a potent antioxidant and suggest that it can control CP-induced hepatotoxicity in rats.
AB  - U našoj studiji ispitivana je uloga oksidacionog stresa u toksičnosti cisplatina (SR) i njegova prevencija pretretmanom selenom (Se). Mužjaci Wistar albino pacova su inicirani jednom dozom cisplatina (7.5 mg CP/kg t.m., i.p.) i selena (6 mg Se/kg t.m, kao Na2SeO3, i.p.) pojedinačno ili u kombinaciji. Rezultati pokazuju da intoksikacija SR uzrokuje oksidacioni stres i promenu glutation redoks statusa: redukovanog (GSH), oksidovanog (GSSG) i GSH/GSSG indeksa (GSH RI), kao i povećanje lipidne peroksidacije (LPO) u jetri pacova. Tretman Se koji je prethodio tretmanu SR pokazao je zaštitne efekte protiv toksičnog delovanja SR na peroksidaciju lipida membrane i promenu glutation redoks statusa u jetri pacova. Na osnovu naših rezultata zaključujemo da Se, deluje kao snažan antioksidans i da može imati ulogu u kontroli SR indukovane hepatotoksičnosti kod pacova.
T2  - Archives of Biological Sciences
T1  - Efekti cisplatina na lipidnu peroksidaciju i glutation redoks status u jetri pacova - zaštitna uloga selena
T1  - Effects of cisplatin on lipid peroxidation and the glutathione redox status in the liver of male rats: The protective role of selenium
IS  - 1
VL  - 62
SP  - 75
EP  - 82
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_246
ER  - 

@article{
author = "Trbojević, Ivana S. and Ognjanović, Branka I. and Đorđević, Nataša Z. and Marković, Snežana D. and Štajn, A.Š. and Gavrić, Jelena and Saičić, Zorica",
year = "2010, 2010",
abstract = "The role of oxidative stress in cisplatin (CP) toxicity and its prevention by pretreatment with selenium (Se) was investigated. Male Wistar albino rats were injected with a single dose of cisplatin (7.5 mg CP/kg b.m., i.p.) and selenium (6 mg Se/kg b.m, as Na2SeO3, i.p.) alone or in combination. The results suggest that CP intoxication induces oxidative stress and alters the glutathione redox status: reduced glutathione (GSH), oxidized glutathione (GSSG) and the GSH/GSSG ratio (GSH RI), resulting in increased lipid peroxidation (LPO) in rat liver. The pretreatment with selenium prior to CP treatment showed a protective effect against the toxic influence of CP on peroxidation of the membrane lipids and an altering of the glutathione redox status in the liver of rats. From our results we conclude that selenium functions as a potent antioxidant and suggest that it can control CP-induced hepatotoxicity in rats., U našoj studiji ispitivana je uloga oksidacionog stresa u toksičnosti cisplatina (SR) i njegova prevencija pretretmanom selenom (Se). Mužjaci Wistar albino pacova su inicirani jednom dozom cisplatina (7.5 mg CP/kg t.m., i.p.) i selena (6 mg Se/kg t.m, kao Na2SeO3, i.p.) pojedinačno ili u kombinaciji. Rezultati pokazuju da intoksikacija SR uzrokuje oksidacioni stres i promenu glutation redoks statusa: redukovanog (GSH), oksidovanog (GSSG) i GSH/GSSG indeksa (GSH RI), kao i povećanje lipidne peroksidacije (LPO) u jetri pacova. Tretman Se koji je prethodio tretmanu SR pokazao je zaštitne efekte protiv toksičnog delovanja SR na peroksidaciju lipida membrane i promenu glutation redoks statusa u jetri pacova. Na osnovu naših rezultata zaključujemo da Se, deluje kao snažan antioksidans i da može imati ulogu u kontroli SR indukovane hepatotoksičnosti kod pacova.",
journal = "Archives of Biological Sciences",
title = "Efekti cisplatina na lipidnu peroksidaciju i glutation redoks status u jetri pacova - zaštitna uloga selena, Effects of cisplatin on lipid peroxidation and the glutathione redox status in the liver of male rats: The protective role of selenium",
number = "1",
volume = "62",
pages = "75-82",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_246"
}

Trbojević, I. S., Ognjanović, B. I., Đorđević, N. Z., Marković, S. D., Štajn, A.Š., Gavrić, J.,& Saičić, Z.. (2010). Efekti cisplatina na lipidnu peroksidaciju i glutation redoks status u jetri pacova - zaštitna uloga selena. in Archives of Biological Sciences, 62(1), 75-82.
https://hdl.handle.net/21.15107/rcub_ibiss_246

Trbojević IS, Ognjanović BI, Đorđević NZ, Marković SD, Štajn A, Gavrić J, Saičić Z. Efekti cisplatina na lipidnu peroksidaciju i glutation redoks status u jetri pacova - zaštitna uloga selena. in Archives of Biological Sciences. 2010;62(1):75-82.
https://hdl.handle.net/21.15107/rcub_ibiss_246 .

Trbojević, Ivana S., Ognjanović, Branka I., Đorđević, Nataša Z., Marković, Snežana D., Štajn, A.Š., Gavrić, Jelena, Saičić, Zorica, "Efekti cisplatina na lipidnu peroksidaciju i glutation redoks status u jetri pacova - zaštitna uloga selena" in Archives of Biological Sciences, 62, no. 1 (2010):75-82,
https://hdl.handle.net/21.15107/rcub_ibiss_246 .

TY  - JOUR
AU  - Marković, Snežana D.
AU  - Đačić, Dragana S.
AU  - Cvetković, Danijela M.
AU  - Obradović, Ana D.
AU  - Žižić, Jovana B.
AU  - Ognjanović, Branka I.
AU  - Štajn, Andraš Š.
AU  - Saičić, Zorica
AU  - Spasić, Mihajlo
PY  - 2010
PY  - 2010
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/491
AB  - Ascorbic acid (Vit C) is a reducing agent that efficiently quenches potentially damaging free radicals. The aim of this study was to investigate effects of high acute dose of Vit C on redox and antioxidative status in blood of rats. Our study included two groups of Wistar albino rats: I - untreated group (control); II - group treated with Vit C (500 mg/kg bw, i.p.). In all cases animals were sacrificed after three days of treatment and blood samples were taken at the day of sacrifice. Concentration of Heinz bodies (HB) was determined in whole blood, while the concentration of reactive oxygen and nitrogen species (ROS and RNS), as well as, parameters of antioxidative defense system were followed in plasma and red blood cells (RBC). Our results showed that Vit C treatment induced higher levels of peroxynitrites and lipid peroxidation in plasma. In RBC, Vit C induced higher level of HB, GSSG/2 GSH ratio and glutathione peroxidase activity, while decreased glutathione reductase activity. In conclusion, acute high doses of Vit C act as prooxidant and induced oxidative stress that resulted in lipid peroxidation in plasma and hemoglobin oxidation in RBC. .
T2  - Kragujevac Journal of Science
T1  - Effects of acute treatment of vitamin C on redox and antioxidative metabolism in plasma and red blood cells of rats
IS  - 32
VL  - null
SP  - 109
EP  - 116
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_491
ER  - 

@article{
author = "Marković, Snežana D. and Đačić, Dragana S. and Cvetković, Danijela M. and Obradović, Ana D. and Žižić, Jovana B. and Ognjanović, Branka I. and Štajn, Andraš Š. and Saičić, Zorica and Spasić, Mihajlo",
year = "2010, 2010",
abstract = "Ascorbic acid (Vit C) is a reducing agent that efficiently quenches potentially damaging free radicals. The aim of this study was to investigate effects of high acute dose of Vit C on redox and antioxidative status in blood of rats. Our study included two groups of Wistar albino rats: I - untreated group (control); II - group treated with Vit C (500 mg/kg bw, i.p.). In all cases animals were sacrificed after three days of treatment and blood samples were taken at the day of sacrifice. Concentration of Heinz bodies (HB) was determined in whole blood, while the concentration of reactive oxygen and nitrogen species (ROS and RNS), as well as, parameters of antioxidative defense system were followed in plasma and red blood cells (RBC). Our results showed that Vit C treatment induced higher levels of peroxynitrites and lipid peroxidation in plasma. In RBC, Vit C induced higher level of HB, GSSG/2 GSH ratio and glutathione peroxidase activity, while decreased glutathione reductase activity. In conclusion, acute high doses of Vit C act as prooxidant and induced oxidative stress that resulted in lipid peroxidation in plasma and hemoglobin oxidation in RBC. .",
journal = "Kragujevac Journal of Science",
title = "Effects of acute treatment of vitamin C on redox and antioxidative metabolism in plasma and red blood cells of rats",
number = "32",
volume = "null",
pages = "109-116",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_491"
}

Marković, S. D., Đačić, D. S., Cvetković, D. M., Obradović, A. D., Žižić, J. B., Ognjanović, B. I., Štajn, A. Š., Saičić, Z.,& Spasić, M.. (2010). Effects of acute treatment of vitamin C on redox and antioxidative metabolism in plasma and red blood cells of rats. in Kragujevac Journal of Science, null(32), 109-116.
https://hdl.handle.net/21.15107/rcub_ibiss_491

Marković SD, Đačić DS, Cvetković DM, Obradović AD, Žižić JB, Ognjanović BI, Štajn AŠ, Saičić Z, Spasić M. Effects of acute treatment of vitamin C on redox and antioxidative metabolism in plasma and red blood cells of rats. in Kragujevac Journal of Science. 2010;null(32):109-116.
https://hdl.handle.net/21.15107/rcub_ibiss_491 .

Marković, Snežana D., Đačić, Dragana S., Cvetković, Danijela M., Obradović, Ana D., Žižić, Jovana B., Ognjanović, Branka I., Štajn, Andraš Š., Saičić, Zorica, Spasić, Mihajlo, "Effects of acute treatment of vitamin C on redox and antioxidative metabolism in plasma and red blood cells of rats" in Kragujevac Journal of Science, null, no. 32 (2010):109-116,
https://hdl.handle.net/21.15107/rcub_ibiss_491 .

TY  - JOUR
AU  - Marković, Snežana D.
AU  - Obradović, Ana D.
AU  - Žižić, Jovana B.
AU  - Ognjanović, Branka I.
AU  - Štajn, A.Š.
AU  - Saičić, Zorica
AU  - Spasić, Mihajlo
PY  - 2010
PY  - 2010
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/262
AB  - In this experiment, we compared the in vivo effects of phenylhydrazine (PHZ) and bleeding treatment on the redox status and glutathione antioxidative mechanism parameters in the plasma and red blood cells (RBC) of rats. Results showed a lower level of reactive oxygen species (ROS), a higher level of lipid peroxidation and the effective antioxidative role of the glutathione system in the blood of bleeding rats. PHZ-treatment induced higher concentrations of ROS and an accumulation of oxidized glutathione in the plasma, while the glutathione system showed a satisfactory antioxidative capacity in the RBC of rats. When comparing the two anemic groups, the PHZ-treated rats showed marked oxidative stress in the plasma.
AB  - Cilj ovog rada je bio da se isprate in vivo efekti fenilhidrazinom (PHZ) i krvarenjem indukovane retikulocitoze na parametre redoks i glutationskog antioksidativnog statusa u plazmi i crvenim krvnim ćelijama (RBC) pacova. Rezultati pokazuju niži nivo reaktivnih vrsta kiseonika (ROS), viši nivo lipidne peroksidacije i efikasnu antioksidacionu ulogu glutationskog sistema u krvi iskvavljenih pacova. Tretman PHZom prouzrokovao je više koncentracije ROSa i akumulaciju oksidovanog glutationa u plazmi, dok je glutationski sistem pokazao efikasan antioksidativni kapacitet u RBCu pacova. Kada se uporede dve anemične grupe, izraženiji oksidacioni stres se javlja u plazmi pacova tretiranih PHZom.
T2  - Archives of Biological Sciences
T1  - Glutationski status u krvi pacova nakon retikulocitoze izazvane fenilhidrazinom i krvarenjem
T1  - Glutathione status in the blood of rats after reticulocytosis induced by phenylhydrazine and bleeding
IS  - 3
VL  - 62
SP  - 589
EP  - 594
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_262
ER  - 

@article{
author = "Marković, Snežana D. and Obradović, Ana D. and Žižić, Jovana B. and Ognjanović, Branka I. and Štajn, A.Š. and Saičić, Zorica and Spasić, Mihajlo",
year = "2010, 2010",
abstract = "In this experiment, we compared the in vivo effects of phenylhydrazine (PHZ) and bleeding treatment on the redox status and glutathione antioxidative mechanism parameters in the plasma and red blood cells (RBC) of rats. Results showed a lower level of reactive oxygen species (ROS), a higher level of lipid peroxidation and the effective antioxidative role of the glutathione system in the blood of bleeding rats. PHZ-treatment induced higher concentrations of ROS and an accumulation of oxidized glutathione in the plasma, while the glutathione system showed a satisfactory antioxidative capacity in the RBC of rats. When comparing the two anemic groups, the PHZ-treated rats showed marked oxidative stress in the plasma., Cilj ovog rada je bio da se isprate in vivo efekti fenilhidrazinom (PHZ) i krvarenjem indukovane retikulocitoze na parametre redoks i glutationskog antioksidativnog statusa u plazmi i crvenim krvnim ćelijama (RBC) pacova. Rezultati pokazuju niži nivo reaktivnih vrsta kiseonika (ROS), viši nivo lipidne peroksidacije i efikasnu antioksidacionu ulogu glutationskog sistema u krvi iskvavljenih pacova. Tretman PHZom prouzrokovao je više koncentracije ROSa i akumulaciju oksidovanog glutationa u plazmi, dok je glutationski sistem pokazao efikasan antioksidativni kapacitet u RBCu pacova. Kada se uporede dve anemične grupe, izraženiji oksidacioni stres se javlja u plazmi pacova tretiranih PHZom.",
journal = "Archives of Biological Sciences",
title = "Glutationski status u krvi pacova nakon retikulocitoze izazvane fenilhidrazinom i krvarenjem, Glutathione status in the blood of rats after reticulocytosis induced by phenylhydrazine and bleeding",
number = "3",
volume = "62",
pages = "589-594",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_262"
}

Marković, S. D., Obradović, A. D., Žižić, J. B., Ognjanović, B. I., Štajn, A.Š., Saičić, Z.,& Spasić, M.. (2010). Glutationski status u krvi pacova nakon retikulocitoze izazvane fenilhidrazinom i krvarenjem. in Archives of Biological Sciences, 62(3), 589-594.
https://hdl.handle.net/21.15107/rcub_ibiss_262

Marković SD, Obradović AD, Žižić JB, Ognjanović BI, Štajn A, Saičić Z, Spasić M. Glutationski status u krvi pacova nakon retikulocitoze izazvane fenilhidrazinom i krvarenjem. in Archives of Biological Sciences. 2010;62(3):589-594.
https://hdl.handle.net/21.15107/rcub_ibiss_262 .

Marković, Snežana D., Obradović, Ana D., Žižić, Jovana B., Ognjanović, Branka I., Štajn, A.Š., Saičić, Zorica, Spasić, Mihajlo, "Glutationski status u krvi pacova nakon retikulocitoze izazvane fenilhidrazinom i krvarenjem" in Archives of Biological Sciences, 62, no. 3 (2010):589-594,
https://hdl.handle.net/21.15107/rcub_ibiss_262 .

TY  - JOUR
AU  - Marković, Snežana D.
AU  - Milošević, Marijana P.
AU  - Đorđević, Nataša Z.
AU  - Ognjanović, Branka I.
AU  - Štajn, A.Š.
AU  - Saičić, Zorica
AU  - Spasić, Mihajlo
PY  - 2009
PY  - 2009
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/221
AB  - In order to investigate daily changes of hematological parameters in bleeding-induced anemia, we treated Wistar albino male rats by daily bleeding (1.5-2 mL of blood from the tail vein for eight days). Blood samples were taken before (on day zero) and on the first to eighth days of bleeding. The values of hematocrit, hemoglobin, and erythrocyte count decreased significantly after the second, sixth, and second days of bleeding, respectively. The number of leuko­cytes and platelets, as well as Heinz body levels, increased significantly after the third and second days of treatment. The percentage of reticulocytes increased significantly from the second day and attained the maximum level (32.55 ± 0.96%) on the eighth day.
AB  - U cilju ispitivanja dnevnih promena hematoloških parametara u toku anemije indukovane dnevnim krvarenjem, tretirali smo Wistar albino pacove dnevnim krvarenjem (1.5-2 ml krvi iz repne vene u toku 8 dana). Uzorci krvi uzimani su pre (0 dan) i 1-8. dana krvarenja. Vrednosti za hematokrit, hemoglobin i broj eritrocita značajno opadaju nakon drugog, šestog i drugog dana krvarenja. Broj leukocita i trombocita, kao i nivo formiranja Heinz-ovih telašaca raste značajno nakon trećeg i drugog dana tretmana. Procenat retikulocita značajno raste od drugog dana i dostiže maksimalni nivo (32.55 ± 0.96 %) osmog dana tremana.
T2  - Archives of Biological Sciences
T1  - Vremenski zavisan tok eksperimentalne anemije u pacova izazvane dnevnim krvarenjem
T1  - Time course of hematological parameters in bleeding-induced anemia
IS  - 2
VL  - 61
SP  - 165
EP  - 170
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_221
ER  - 

@article{
author = "Marković, Snežana D. and Milošević, Marijana P. and Đorđević, Nataša Z. and Ognjanović, Branka I. and Štajn, A.Š. and Saičić, Zorica and Spasić, Mihajlo",
year = "2009, 2009",
abstract = "In order to investigate daily changes of hematological parameters in bleeding-induced anemia, we treated Wistar albino male rats by daily bleeding (1.5-2 mL of blood from the tail vein for eight days). Blood samples were taken before (on day zero) and on the first to eighth days of bleeding. The values of hematocrit, hemoglobin, and erythrocyte count decreased significantly after the second, sixth, and second days of bleeding, respectively. The number of leuko­cytes and platelets, as well as Heinz body levels, increased significantly after the third and second days of treatment. The percentage of reticulocytes increased significantly from the second day and attained the maximum level (32.55 ± 0.96%) on the eighth day., U cilju ispitivanja dnevnih promena hematoloških parametara u toku anemije indukovane dnevnim krvarenjem, tretirali smo Wistar albino pacove dnevnim krvarenjem (1.5-2 ml krvi iz repne vene u toku 8 dana). Uzorci krvi uzimani su pre (0 dan) i 1-8. dana krvarenja. Vrednosti za hematokrit, hemoglobin i broj eritrocita značajno opadaju nakon drugog, šestog i drugog dana krvarenja. Broj leukocita i trombocita, kao i nivo formiranja Heinz-ovih telašaca raste značajno nakon trećeg i drugog dana tretmana. Procenat retikulocita značajno raste od drugog dana i dostiže maksimalni nivo (32.55 ± 0.96 %) osmog dana tremana.",
journal = "Archives of Biological Sciences",
title = "Vremenski zavisan tok eksperimentalne anemije u pacova izazvane dnevnim krvarenjem, Time course of hematological parameters in bleeding-induced anemia",
number = "2",
volume = "61",
pages = "165-170",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_221"
}

Marković, S. D., Milošević, M. P., Đorđević, N. Z., Ognjanović, B. I., Štajn, A.Š., Saičić, Z.,& Spasić, M.. (2009). Vremenski zavisan tok eksperimentalne anemije u pacova izazvane dnevnim krvarenjem. in Archives of Biological Sciences, 61(2), 165-170.
https://hdl.handle.net/21.15107/rcub_ibiss_221

Marković SD, Milošević MP, Đorđević NZ, Ognjanović BI, Štajn A, Saičić Z, Spasić M. Vremenski zavisan tok eksperimentalne anemije u pacova izazvane dnevnim krvarenjem. in Archives of Biological Sciences. 2009;61(2):165-170.
https://hdl.handle.net/21.15107/rcub_ibiss_221 .

Marković, Snežana D., Milošević, Marijana P., Đorđević, Nataša Z., Ognjanović, Branka I., Štajn, A.Š., Saičić, Zorica, Spasić, Mihajlo, "Vremenski zavisan tok eksperimentalne anemije u pacova izazvane dnevnim krvarenjem" in Archives of Biological Sciences, 61, no. 2 (2009):165-170,
https://hdl.handle.net/21.15107/rcub_ibiss_221 .

TY  - JOUR
AU  - Ognjanović, Branka I.
AU  - Milovanović, Jasmina G.
AU  - Đorđević, Nataša Z.
AU  - Marković, Snežana D.
AU  - Žikić, Radoslav V.
AU  - Štajn, Andraš Š.
AU  - Saičić, Zorica
PY  - 2008
PY  - 2008
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/490
AB  - Fish are the most important organisms in the biomonitoring of aquatic ecosystems. A number of pollutants may cause the oxidative stress in the organism of fish. The monitoring of parameters of oxidative stress in tissues of fish is a good biomarker in the assessment of the condition of environment. Catch of commercially important species of fish, hake (Merluccius merluccius L.) was carried out in front of sea-port Bar (South Adriatic) at the end of May 2005. The parameters of oxidative stress: concentrations of lipid peroxides (LP) and reduced glutathione (GSH) were determined in liver and white muscle. Physical-chemical parameters (salinity, concentration of dissolved oxygen and temperature) as well as the concentrations of nitrites, nitrates and detergents in the water of investigated locality were determined. The obtained results showed the tissue specificity that was the consequence of different metabolic and antioxidative activities. In the liver of hake, the increased concentration of LP was found in comparison to the white muscle, whereas in white muscle the increased concentration of GSH was recorded in comparison to the liver. These results suggest that the intensity of oxidative stress was higher in the liver in comparison to the white muscle, which is the consequence of increased presence of pollutants in water of the investigated locality. .
T2  - Kragujevac Journal of Science
T1  - Parameters of oxidative stress in liver and white muscle of hake (Merluccius merluccius L.) from the Adriatic Sea
IS  - 30
VL  - null
SP  - 137
EP  - 144
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_490
ER  - 

@article{
author = "Ognjanović, Branka I. and Milovanović, Jasmina G. and Đorđević, Nataša Z. and Marković, Snežana D. and Žikić, Radoslav V. and Štajn, Andraš Š. and Saičić, Zorica",
year = "2008, 2008",
abstract = "Fish are the most important organisms in the biomonitoring of aquatic ecosystems. A number of pollutants may cause the oxidative stress in the organism of fish. The monitoring of parameters of oxidative stress in tissues of fish is a good biomarker in the assessment of the condition of environment. Catch of commercially important species of fish, hake (Merluccius merluccius L.) was carried out in front of sea-port Bar (South Adriatic) at the end of May 2005. The parameters of oxidative stress: concentrations of lipid peroxides (LP) and reduced glutathione (GSH) were determined in liver and white muscle. Physical-chemical parameters (salinity, concentration of dissolved oxygen and temperature) as well as the concentrations of nitrites, nitrates and detergents in the water of investigated locality were determined. The obtained results showed the tissue specificity that was the consequence of different metabolic and antioxidative activities. In the liver of hake, the increased concentration of LP was found in comparison to the white muscle, whereas in white muscle the increased concentration of GSH was recorded in comparison to the liver. These results suggest that the intensity of oxidative stress was higher in the liver in comparison to the white muscle, which is the consequence of increased presence of pollutants in water of the investigated locality. .",
journal = "Kragujevac Journal of Science",
title = "Parameters of oxidative stress in liver and white muscle of hake (Merluccius merluccius L.) from the Adriatic Sea",
number = "30",
volume = "null",
pages = "137-144",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_490"
}

Ognjanović, B. I., Milovanović, J. G., Đorđević, N. Z., Marković, S. D., Žikić, R. V., Štajn, A. Š.,& Saičić, Z.. (2008). Parameters of oxidative stress in liver and white muscle of hake (Merluccius merluccius L.) from the Adriatic Sea. in Kragujevac Journal of Science, null(30), 137-144.
https://hdl.handle.net/21.15107/rcub_ibiss_490

Ognjanović BI, Milovanović JG, Đorđević NZ, Marković SD, Žikić RV, Štajn AŠ, Saičić Z. Parameters of oxidative stress in liver and white muscle of hake (Merluccius merluccius L.) from the Adriatic Sea. in Kragujevac Journal of Science. 2008;null(30):137-144.
https://hdl.handle.net/21.15107/rcub_ibiss_490 .

Ognjanović, Branka I., Milovanović, Jasmina G., Đorđević, Nataša Z., Marković, Snežana D., Žikić, Radoslav V., Štajn, Andraš Š., Saičić, Zorica, "Parameters of oxidative stress in liver and white muscle of hake (Merluccius merluccius L.) from the Adriatic Sea" in Kragujevac Journal of Science, null, no. 30 (2008):137-144,
https://hdl.handle.net/21.15107/rcub_ibiss_490 .

TY  - JOUR
AU  - Ognjanović, Branka I.
AU  - Filipović, Jasmina Ž.
AU  - Marković, Snežana D.
AU  - Žikić, Radoslav V.
AU  - Štajn, Andraš Š.
AU  - Petrović, Vojislav M.
AU  - Saičić, Zorica
PY  - 2006
PY  - 2006
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/256
AB  - Fish are the most important organisms used in biomonitoring of aquatic ecosystems. Parameters of oxidative stress in fish tissues represent significant biomarkers in the assessment of the status of environment. Specimens of hake (Merluccius merluccius L.) and sea bream (Pagellus erythrinus L.) were collected at the end of May 2005 from the locality in front of sea-port Bar (South Adriatic Sea). Parameters of oxidative stress (concentration of lipid peroxidase - LP and reduced glutathione - GSH) were determined in the liver and white muscle of hake and sea bream. Physical-chemical parameters (salinity, concentration of dissolved oxygen and temperature) were determined in water of the investigated locality. Obtained results showed that the concentration of LP was higher in liver of hake and sea bream in comparison to white muscle. However, significantly higher concentration of GSH was found in white muscle of hake and sea bream in comparison to liver. These changes of oxidative stress parameters point to tissue specificity, which is the consequence of different metabolic and antioxidative activity. Inter-specific differences were also established. Higher concentrations of LP and GSH in liver of hake and in white muscle of sea bream were recorded, due to the changes of physical-chemical parameters of environment. The intensity of oxidative stress in liver of hake and sea bream was higher in comparison to muscle.
AB  - Ribe predstavljaju najznačajnije organizme koji se koriste u biomonitoringu vodenih ekosistema. Parametri oksidacionog stresa u tkivima riba predstavljaju značajne biomarkere u proceni stanja životne sredine. Krajem maja 2005. godine uzorkovane su jedinke oslića (Merluccius merluccius L.) i arbuna (Pagellus erythrinus L.) sa lokaliteta ispred luke Bar (Južni Jadran). Parametri oksidacionog stresa (koncentracija lipidnih peroksida - LP i redukovani glutationa - GSH) su određivani u tkivima jetre i belog mišića oslića i arbuna. U vodi ispitivanog lokaliteta određivani su i fizičko-hemijski parametri (salinitet, koncentracija rastvorenog kiseonika i temperatura). Dobijeni rezultati su pokazali da je koncentracija LP veća u jetri oslića i arbuna u odnosu na belo mišićno tkivo. Međutim, zabeležena je znatno veća koncentracija GSH u belom mišiću i oslića i arbuna u odnosu na jetru. Ovakve promene parametara oksidacionog stresa ukazuju na tkivnu specifičnost, kao posledica različite metaboličke i antioksidacione aktivnosti. Ustanovljene su i interspecijske razlike, zabeležena je veća koncentracija LP i GSH u jetri oslića, kao i u belom mišiću arbuna, kao posledica promena fizičko-hemijskih parametara sredine i prisustva polutanata. Intenzitet oksidacionog stresa u jetri oslića i arbuna je bio viši u odnosu na mišiće.
T2  - Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica
T1  - Koncentracije lipidnih peroksida i glutationa u jetri i belom mišiću oslića (Merluccius merluccius L.) i arbuna (Pagellus erythrinus L.) iz Jadranskog mora
T1  - Lipid peroxidation and glutathione content in the liver and white muscle of hake (Merluccius merluccius L.) and sea bream (Pagellus erythrinus L.) from the Adriatic Sea
IS  - 2
VL  - 42
SP  - 129
EP  - 139
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_256
ER  - 

@article{
author = "Ognjanović, Branka I. and Filipović, Jasmina Ž. and Marković, Snežana D. and Žikić, Radoslav V. and Štajn, Andraš Š. and Petrović, Vojislav M. and Saičić, Zorica",
year = "2006, 2006",
abstract = "Fish are the most important organisms used in biomonitoring of aquatic ecosystems. Parameters of oxidative stress in fish tissues represent significant biomarkers in the assessment of the status of environment. Specimens of hake (Merluccius merluccius L.) and sea bream (Pagellus erythrinus L.) were collected at the end of May 2005 from the locality in front of sea-port Bar (South Adriatic Sea). Parameters of oxidative stress (concentration of lipid peroxidase - LP and reduced glutathione - GSH) were determined in the liver and white muscle of hake and sea bream. Physical-chemical parameters (salinity, concentration of dissolved oxygen and temperature) were determined in water of the investigated locality. Obtained results showed that the concentration of LP was higher in liver of hake and sea bream in comparison to white muscle. However, significantly higher concentration of GSH was found in white muscle of hake and sea bream in comparison to liver. These changes of oxidative stress parameters point to tissue specificity, which is the consequence of different metabolic and antioxidative activity. Inter-specific differences were also established. Higher concentrations of LP and GSH in liver of hake and in white muscle of sea bream were recorded, due to the changes of physical-chemical parameters of environment. The intensity of oxidative stress in liver of hake and sea bream was higher in comparison to muscle., Ribe predstavljaju najznačajnije organizme koji se koriste u biomonitoringu vodenih ekosistema. Parametri oksidacionog stresa u tkivima riba predstavljaju značajne biomarkere u proceni stanja životne sredine. Krajem maja 2005. godine uzorkovane su jedinke oslića (Merluccius merluccius L.) i arbuna (Pagellus erythrinus L.) sa lokaliteta ispred luke Bar (Južni Jadran). Parametri oksidacionog stresa (koncentracija lipidnih peroksida - LP i redukovani glutationa - GSH) su određivani u tkivima jetre i belog mišića oslića i arbuna. U vodi ispitivanog lokaliteta određivani su i fizičko-hemijski parametri (salinitet, koncentracija rastvorenog kiseonika i temperatura). Dobijeni rezultati su pokazali da je koncentracija LP veća u jetri oslića i arbuna u odnosu na belo mišićno tkivo. Međutim, zabeležena je znatno veća koncentracija GSH u belom mišiću i oslića i arbuna u odnosu na jetru. Ovakve promene parametara oksidacionog stresa ukazuju na tkivnu specifičnost, kao posledica različite metaboličke i antioksidacione aktivnosti. Ustanovljene su i interspecijske razlike, zabeležena je veća koncentracija LP i GSH u jetri oslića, kao i u belom mišiću arbuna, kao posledica promena fizičko-hemijskih parametara sredine i prisustva polutanata. Intenzitet oksidacionog stresa u jetri oslića i arbuna je bio viši u odnosu na mišiće.",
journal = "Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica",
title = "Koncentracije lipidnih peroksida i glutationa u jetri i belom mišiću oslića (Merluccius merluccius L.) i arbuna (Pagellus erythrinus L.) iz Jadranskog mora, Lipid peroxidation and glutathione content in the liver and white muscle of hake (Merluccius merluccius L.) and sea bream (Pagellus erythrinus L.) from the Adriatic Sea",
number = "2",
volume = "42",
pages = "129-139",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_256"
}

Ognjanović, B. I., Filipović, J. Ž., Marković, S. D., Žikić, R. V., Štajn, A. Š., Petrović, V. M.,& Saičić, Z.. (2006). Koncentracije lipidnih peroksida i glutationa u jetri i belom mišiću oslića (Merluccius merluccius L.) i arbuna (Pagellus erythrinus L.) iz Jadranskog mora. in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica, 42(2), 129-139.
https://hdl.handle.net/21.15107/rcub_ibiss_256

Ognjanović BI, Filipović JŽ, Marković SD, Žikić RV, Štajn AŠ, Petrović VM, Saičić Z. Koncentracije lipidnih peroksida i glutationa u jetri i belom mišiću oslića (Merluccius merluccius L.) i arbuna (Pagellus erythrinus L.) iz Jadranskog mora. in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica. 2006;42(2):129-139.
https://hdl.handle.net/21.15107/rcub_ibiss_256 .

Ognjanović, Branka I., Filipović, Jasmina Ž., Marković, Snežana D., Žikić, Radoslav V., Štajn, Andraš Š., Petrović, Vojislav M., Saičić, Zorica, "Koncentracije lipidnih peroksida i glutationa u jetri i belom mišiću oslića (Merluccius merluccius L.) i arbuna (Pagellus erythrinus L.) iz Jadranskog mora" in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica, 42, no. 2 (2006):129-139,
https://hdl.handle.net/21.15107/rcub_ibiss_256 .

TY  - JOUR
AU  - Ognjanović, Branka I.
AU  - Marković, Snežana D.
AU  - Pavlović, Slađan
AU  - Žikić, Radoslav V.
AU  - Štajn, Andraš Š.
AU  - Ziemnicki, Kazimir
AU  - Petrović, Vojislav M.
AU  - Saičić, Zorica
PY  - 2006
PY  - 2006
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/367
AB  - The effects of cadmium (Cd, 15 mg/kg/day) on the blood antioxidant defense system and the possible protective effects of selenium (Se, 7 μg/kg/day) were studied. Chronic Cd administration resulted in increased activities of copper, zinc superoxide dismutase (CuZn SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) in red blood cells (RBC), as well as glutathione S-transferase (GST) activity and vitamin E (Vit E) concentration in the plasma. Se induced a significant increase in GSH-Px and GST activities, as well as concentrations of vitamin C and E. Thus, the mechanism by which Se decreases Cd toxicity in rats, seems to rely on the protection of the antioxidant defense system in blood, possibly by forming non-toxic cadmium selenide. The accumulation of Cd in RBC also decreased significantly upon co-exposure to Se. The obtained results show, that Cd exhibit toxic effects on the antioxidant defense system in the blood of rats and that Se demonstrates the protective effect against Cd toxicity.
AB  - U ovom radu ispitivan je efekat kadmijuma (Cd, 15 mg/kg/danu) na antioksidacioni zaštitni sistem i moguća zaštitna uloga selena (Se, 7 μg/kg/danu). Posle hroničnog tretmana Cd značajno se povećavaju aktivnosti bakar, cink superoksid dismutaze (CuZn SOD), katalaze (CAT) i glutation peroksidaze (GSH-Px) u crvenim krvnim ćelijama (RBC), kao i aktivnost glutation S-transferaze (GST) i koncentracije vitamina E (Vit E) u plazmi. Selen značajno povećava aktivnosti enzima GSH-Px i GST, kao i koncentracije vitamina C i E. Mehanizam kojim selen smanjuje toksičnost Cd kod pacova odnosi se na zaštitu antioksidacionog sistema u krvi, posebno formiranje ne-toksičnih kadmium-selenita. Akumulacija Cd u RBC takođe je značajno smanjena posle ko-tretmana selenom. Dobijeni rezultati pokazuju da Cd ispoljava toksične efekte na antioksidacioni zaštitni sistem u krvi pacova i da Se pokazuje zaštitni efekat protiv toksičnosti Cd.
T2  - Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica
T1  - Zaštitni efekat selena na antioksidacioni zaštitni sistem u krvi pacova tretiranih kadmijumom
T1  - Protective effect of selenium on antioxidant defense system in the blood of rats treated with cadmium
IS  - 3
VL  - 42
SP  - 247
EP  - 256
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_367
ER  - 

@article{
author = "Ognjanović, Branka I. and Marković, Snežana D. and Pavlović, Slađan and Žikić, Radoslav V. and Štajn, Andraš Š. and Ziemnicki, Kazimir and Petrović, Vojislav M. and Saičić, Zorica",
year = "2006, 2006",
abstract = "The effects of cadmium (Cd, 15 mg/kg/day) on the blood antioxidant defense system and the possible protective effects of selenium (Se, 7 μg/kg/day) were studied. Chronic Cd administration resulted in increased activities of copper, zinc superoxide dismutase (CuZn SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) in red blood cells (RBC), as well as glutathione S-transferase (GST) activity and vitamin E (Vit E) concentration in the plasma. Se induced a significant increase in GSH-Px and GST activities, as well as concentrations of vitamin C and E. Thus, the mechanism by which Se decreases Cd toxicity in rats, seems to rely on the protection of the antioxidant defense system in blood, possibly by forming non-toxic cadmium selenide. The accumulation of Cd in RBC also decreased significantly upon co-exposure to Se. The obtained results show, that Cd exhibit toxic effects on the antioxidant defense system in the blood of rats and that Se demonstrates the protective effect against Cd toxicity., U ovom radu ispitivan je efekat kadmijuma (Cd, 15 mg/kg/danu) na antioksidacioni zaštitni sistem i moguća zaštitna uloga selena (Se, 7 μg/kg/danu). Posle hroničnog tretmana Cd značajno se povećavaju aktivnosti bakar, cink superoksid dismutaze (CuZn SOD), katalaze (CAT) i glutation peroksidaze (GSH-Px) u crvenim krvnim ćelijama (RBC), kao i aktivnost glutation S-transferaze (GST) i koncentracije vitamina E (Vit E) u plazmi. Selen značajno povećava aktivnosti enzima GSH-Px i GST, kao i koncentracije vitamina C i E. Mehanizam kojim selen smanjuje toksičnost Cd kod pacova odnosi se na zaštitu antioksidacionog sistema u krvi, posebno formiranje ne-toksičnih kadmium-selenita. Akumulacija Cd u RBC takođe je značajno smanjena posle ko-tretmana selenom. Dobijeni rezultati pokazuju da Cd ispoljava toksične efekte na antioksidacioni zaštitni sistem u krvi pacova i da Se pokazuje zaštitni efekat protiv toksičnosti Cd.",
journal = "Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica",
title = "Zaštitni efekat selena na antioksidacioni zaštitni sistem u krvi pacova tretiranih kadmijumom, Protective effect of selenium on antioxidant defense system in the blood of rats treated with cadmium",
number = "3",
volume = "42",
pages = "247-256",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_367"
}

Ognjanović, B. I., Marković, S. D., Pavlović, S., Žikić, R. V., Štajn, A. Š., Ziemnicki, K., Petrović, V. M.,& Saičić, Z.. (2006). Zaštitni efekat selena na antioksidacioni zaštitni sistem u krvi pacova tretiranih kadmijumom. in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica, 42(3), 247-256.
https://hdl.handle.net/21.15107/rcub_ibiss_367

Ognjanović BI, Marković SD, Pavlović S, Žikić RV, Štajn AŠ, Ziemnicki K, Petrović VM, Saičić Z. Zaštitni efekat selena na antioksidacioni zaštitni sistem u krvi pacova tretiranih kadmijumom. in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica. 2006;42(3):247-256.
https://hdl.handle.net/21.15107/rcub_ibiss_367 .

Ognjanović, Branka I., Marković, Snežana D., Pavlović, Slađan, Žikić, Radoslav V., Štajn, Andraš Š., Ziemnicki, Kazimir, Petrović, Vojislav M., Saičić, Zorica, "Zaštitni efekat selena na antioksidacioni zaštitni sistem u krvi pacova tretiranih kadmijumom" in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica, 42, no. 3 (2006):247-256,
https://hdl.handle.net/21.15107/rcub_ibiss_367 .

TY  - JOUR
AU  - Filipović, Jasmina Ž.
AU  - Nikolić, Dubravka M.
AU  - Ognjanović, Branka I.
AU  - Marković, Snežana D.
AU  - Žikić, Radoslav V.
AU  - Štajn, Andraš Š.
AU  - Petrović, Vojislav M.
AU  - Saičić, Zorica
PY  - 2006
PY  - 2006
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/378
AB  - Fish are the most important organisms used in biomonitoring of aquatic ecosystems. Parameters of oxidative stress in fish tissues represent significant biomarkers in the assessment of the status of environment. Specimens of hake (Merluccius merluccius L) and red mullet (Mullus barbatus L) were collected from the locality in front of sea-port Bar (South Adriatic Sea) at the end of May 2005. Activity of the enzymes of the antioxidative system (superoxide dismutase - SOD and catalase - CAT) and parameters of oxidative stress (lipid peroxidation - LP and reduced glutathione - GSH content) were determined in the liver of hake and red mullet. Obtained results showed that the activities of SOD and CAT were significantly lower in the liver of hake than in red mullet. Higher concentrations of LP and GSH in liver of hake were recorded, due to the changes of physical-chemical parameters of environment. The intensity of oxidative stress in liver of hake was higher in comparison to red mullet.
AB  - Ribe predstavljaju najznačajnije organizme koji se koriste u biomonitoringu vodenih ekosistema. Parametri oksidacionog stresa u tkivima riba predstavljaju značajne biomarkere u proceni stanja životne sredine. Krajem maja 2005. godine uzorkovane su jedinke oslića (Merluccius merluccius L) i trlje (Mullus barbatus L) sa lokaliteta ispred luke Bar (Južni Jadran). Aktivnost enzima antioksidacionog sistema (superoksid dismutaze - SOD i katalaze - CAT) i parametri oksidacionog stresa (koncentracija lipidnih peroksida - LP i redukovanog glutationa - GSH) su određivani u jetri oslića i trlje. Dobijeni rezultati su pokazali da su aktivnosti SOD i CAT značajno manje u jetri oslića nego kod trlje. Zabeležena je veća koncentracija LP i GSH u jetri oslića, kao posledica promena fizičko-hemijskih parametara sredine i prisustva polutanata. Intenzitet oksidacionog stresa u jetri oslića je bio viši u odnosu na trlju.
T2  - Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica
T1  - Aktivnost enzima antioksidacione zaštite, koncentracija glutationa i lipidnih peroksida u jetri dve vrste riba iz Jadranskog mora
T1  - Activity of the enzymes of the antioxidative system, glutathione and lipid peroxidation content in the liver of two fish species from the Adriatic sea
IS  - 3
VL  - 42
SP  - 257
EP  - 262
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_378
ER  - 

@article{
author = "Filipović, Jasmina Ž. and Nikolić, Dubravka M. and Ognjanović, Branka I. and Marković, Snežana D. and Žikić, Radoslav V. and Štajn, Andraš Š. and Petrović, Vojislav M. and Saičić, Zorica",
year = "2006, 2006",
abstract = "Fish are the most important organisms used in biomonitoring of aquatic ecosystems. Parameters of oxidative stress in fish tissues represent significant biomarkers in the assessment of the status of environment. Specimens of hake (Merluccius merluccius L) and red mullet (Mullus barbatus L) were collected from the locality in front of sea-port Bar (South Adriatic Sea) at the end of May 2005. Activity of the enzymes of the antioxidative system (superoxide dismutase - SOD and catalase - CAT) and parameters of oxidative stress (lipid peroxidation - LP and reduced glutathione - GSH content) were determined in the liver of hake and red mullet. Obtained results showed that the activities of SOD and CAT were significantly lower in the liver of hake than in red mullet. Higher concentrations of LP and GSH in liver of hake were recorded, due to the changes of physical-chemical parameters of environment. The intensity of oxidative stress in liver of hake was higher in comparison to red mullet., Ribe predstavljaju najznačajnije organizme koji se koriste u biomonitoringu vodenih ekosistema. Parametri oksidacionog stresa u tkivima riba predstavljaju značajne biomarkere u proceni stanja životne sredine. Krajem maja 2005. godine uzorkovane su jedinke oslića (Merluccius merluccius L) i trlje (Mullus barbatus L) sa lokaliteta ispred luke Bar (Južni Jadran). Aktivnost enzima antioksidacionog sistema (superoksid dismutaze - SOD i katalaze - CAT) i parametri oksidacionog stresa (koncentracija lipidnih peroksida - LP i redukovanog glutationa - GSH) su određivani u jetri oslića i trlje. Dobijeni rezultati su pokazali da su aktivnosti SOD i CAT značajno manje u jetri oslića nego kod trlje. Zabeležena je veća koncentracija LP i GSH u jetri oslića, kao posledica promena fizičko-hemijskih parametara sredine i prisustva polutanata. Intenzitet oksidacionog stresa u jetri oslića je bio viši u odnosu na trlju.",
journal = "Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica",
title = "Aktivnost enzima antioksidacione zaštite, koncentracija glutationa i lipidnih peroksida u jetri dve vrste riba iz Jadranskog mora, Activity of the enzymes of the antioxidative system, glutathione and lipid peroxidation content in the liver of two fish species from the Adriatic sea",
number = "3",
volume = "42",
pages = "257-262",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_378"
}

Filipović, J. Ž., Nikolić, D. M., Ognjanović, B. I., Marković, S. D., Žikić, R. V., Štajn, A. Š., Petrović, V. M.,& Saičić, Z.. (2006). Aktivnost enzima antioksidacione zaštite, koncentracija glutationa i lipidnih peroksida u jetri dve vrste riba iz Jadranskog mora. in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica, 42(3), 257-262.
https://hdl.handle.net/21.15107/rcub_ibiss_378

Filipović JŽ, Nikolić DM, Ognjanović BI, Marković SD, Žikić RV, Štajn AŠ, Petrović VM, Saičić Z. Aktivnost enzima antioksidacione zaštite, koncentracija glutationa i lipidnih peroksida u jetri dve vrste riba iz Jadranskog mora. in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica. 2006;42(3):257-262.
https://hdl.handle.net/21.15107/rcub_ibiss_378 .

Filipović, Jasmina Ž., Nikolić, Dubravka M., Ognjanović, Branka I., Marković, Snežana D., Žikić, Radoslav V., Štajn, Andraš Š., Petrović, Vojislav M., Saičić, Zorica, "Aktivnost enzima antioksidacione zaštite, koncentracija glutationa i lipidnih peroksida u jetri dve vrste riba iz Jadranskog mora" in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica, 42, no. 3 (2006):257-262,
https://hdl.handle.net/21.15107/rcub_ibiss_378 .

TY  - JOUR
AU  - Marković, Snežana D.
AU  - Dragićević-Đoković, Ljiljana M.
AU  - Đorđević, Nataša Z.
AU  - Ognjanović, Branka I.
AU  - Štajn, Andraš Š.
AU  - Žikić, Radoslav V.
AU  - Petrović, Vojislav M.
AU  - Babić, Goran M.
AU  - Saičić, Zorica
PY  - 2006
PY  - 2006
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/222
AB  - Preeclampsia represents a pregnancy specific syndrome characterized by elevated arterial blood pressure and proteinuria. The aim of this study was to evaluate whole blood and erythrocytes energy status in healthy and preeclamptic women. Our study involved 18 healthy (control) and 19 preeclamptic women. Diagnosis of preeclampsia was done according to the recommendation of International Society for the Study of Hypertension in Pregnancy. After blood collection and erythrocytes extraction, the next parameters were followed: concentrations of lactate and adenine nucleotides (ATP, ADP and AMP). Results showed increased concentrations of lactate and ATP in whole blood of preeclamptic, vs. control pregnant women. All parameters of energy status were also elevated in erythrocites of preeclamptic women (elevation of ADP level was significant). This study suggests that preeclamsia was followed by an elevation of all parameters of energy status in whole blood and in erythrocytes, as a result of increased rate of glycolysis. .
AB  - Preeklampsija predstavlja za trudnoću specifičan sindrom koji se karakteriše povišenim krvnim pritiskom i proteinurijom. Cilj istraživanja je određivanje energetskog statusa pune krvi i eritrocita zdravih i trudnica sa preeklampsijom. Ispitivanjem je bilo obuhvaćeno 18 zdravih i 19 trudnica sa preeklampsijom. Dijagnoza preeklampsije je postavljena prema preporukama International Society for the Study of Hypertension in Pregnancy. Nakon uzimanja krvi i ekstrakcije eritrocita praćeni su sledeći parametri: koncentracije laktata i adenin nukleotida (ATP, ADP i AMP). Rezultati su pokazali povećanje koncentracija laktata i ATP u punoj krvi trudnica sa preeklampsijom u odnosu na kontrolne trudnice. U eritrocitima, svi parametri energetskog statusa su bili povećani u preeklampsiji (povećanje ADP nivoa je bilo značajno). Ova studija pokazuje da je preeklampsija praćena povećanjem svih parametara energetskog statusa u punoj krvi i eritrocitima, kao posledica stimulisanog intenziteta procesa glikolize. .
T2  - Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica
T1  - Energetski status u krvi i eritrocitima trudnica sa preeklampsijom
T1  - Energy status of whole blood and erythrocytes in preeclampsia
IS  - 1
VL  - 42
SP  - 51
EP  - 56
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_222
ER  - 

@article{
author = "Marković, Snežana D. and Dragićević-Đoković, Ljiljana M. and Đorđević, Nataša Z. and Ognjanović, Branka I. and Štajn, Andraš Š. and Žikić, Radoslav V. and Petrović, Vojislav M. and Babić, Goran M. and Saičić, Zorica",
year = "2006, 2006",
abstract = "Preeclampsia represents a pregnancy specific syndrome characterized by elevated arterial blood pressure and proteinuria. The aim of this study was to evaluate whole blood and erythrocytes energy status in healthy and preeclamptic women. Our study involved 18 healthy (control) and 19 preeclamptic women. Diagnosis of preeclampsia was done according to the recommendation of International Society for the Study of Hypertension in Pregnancy. After blood collection and erythrocytes extraction, the next parameters were followed: concentrations of lactate and adenine nucleotides (ATP, ADP and AMP). Results showed increased concentrations of lactate and ATP in whole blood of preeclamptic, vs. control pregnant women. All parameters of energy status were also elevated in erythrocites of preeclamptic women (elevation of ADP level was significant). This study suggests that preeclamsia was followed by an elevation of all parameters of energy status in whole blood and in erythrocytes, as a result of increased rate of glycolysis. ., Preeklampsija predstavlja za trudnoću specifičan sindrom koji se karakteriše povišenim krvnim pritiskom i proteinurijom. Cilj istraživanja je određivanje energetskog statusa pune krvi i eritrocita zdravih i trudnica sa preeklampsijom. Ispitivanjem je bilo obuhvaćeno 18 zdravih i 19 trudnica sa preeklampsijom. Dijagnoza preeklampsije je postavljena prema preporukama International Society for the Study of Hypertension in Pregnancy. Nakon uzimanja krvi i ekstrakcije eritrocita praćeni su sledeći parametri: koncentracije laktata i adenin nukleotida (ATP, ADP i AMP). Rezultati su pokazali povećanje koncentracija laktata i ATP u punoj krvi trudnica sa preeklampsijom u odnosu na kontrolne trudnice. U eritrocitima, svi parametri energetskog statusa su bili povećani u preeklampsiji (povećanje ADP nivoa je bilo značajno). Ova studija pokazuje da je preeklampsija praćena povećanjem svih parametara energetskog statusa u punoj krvi i eritrocitima, kao posledica stimulisanog intenziteta procesa glikolize. .",
journal = "Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica",
title = "Energetski status u krvi i eritrocitima trudnica sa preeklampsijom, Energy status of whole blood and erythrocytes in preeclampsia",
number = "1",
volume = "42",
pages = "51-56",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_222"
}

Marković, S. D., Dragićević-Đoković, L. M., Đorđević, N. Z., Ognjanović, B. I., Štajn, A. Š., Žikić, R. V., Petrović, V. M., Babić, G. M.,& Saičić, Z.. (2006). Energetski status u krvi i eritrocitima trudnica sa preeklampsijom. in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica, 42(1), 51-56.
https://hdl.handle.net/21.15107/rcub_ibiss_222

Marković SD, Dragićević-Đoković LM, Đorđević NZ, Ognjanović BI, Štajn AŠ, Žikić RV, Petrović VM, Babić GM, Saičić Z. Energetski status u krvi i eritrocitima trudnica sa preeklampsijom. in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica. 2006;42(1):51-56.
https://hdl.handle.net/21.15107/rcub_ibiss_222 .

Marković, Snežana D., Dragićević-Đoković, Ljiljana M., Đorđević, Nataša Z., Ognjanović, Branka I., Štajn, Andraš Š., Žikić, Radoslav V., Petrović, Vojislav M., Babić, Goran M., Saičić, Zorica, "Energetski status u krvi i eritrocitima trudnica sa preeklampsijom" in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica, 42, no. 1 (2006):51-56,
https://hdl.handle.net/21.15107/rcub_ibiss_222 .

TY  - JOUR
AU  - Đorđević, Nataša Z.
AU  - Babić, Goran M.
AU  - Marković, Snežana D.
AU  - Ognjanović, Branka I.
AU  - Štajn, Andraš Š.
AU  - Žikić, Radoslav V.
AU  - Petrović, Vojislav M.
AU  - Saičić, Zorica
PY  - 2006
PY  - 2006
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/345
AB  - Preeclampsia represents a pregnancy specific syndrome with high rate of both maternal and neonatal morbidity and mortality. The maternal syndrome is characterized by elevated arterial blood pressure and proteinuria. Several recent studies have reported that there is a disbalance of oxidant/antioxidant system in women with preeclampsia, and this factor might contribute to the pathogenesis of the disease. Our study involved 22 healthy (control) and 20 preeclamptic women. Diagnosis of preeclampsia was done according to the recommendation of International Society for the Study of Hypertension in Pregnancy. After blood collection, the next parameters were followed in erythrocytes: concentration of lipid peroxides (TBARS) non-enzymatic components (reduced glutathione - GSH, oxidized glutathione GSSG) and activities of enzymatic components of AOS (glutathione peroxidase GSH-Px, glutathione reductase - GR and glutathione-S-transferase - GST). Results of this study showed that concentration of TBARS and activity of GST were significantly higher, while activity of GR was significantly lower in erythrocytes of preeclamptic, vs. healthy women. Concentrations of GSH, GSSG and activity GSH-Px did not change significantly. Increased concentration of TBARS and activity of GST, as well as disorder in GSH and GSH-dependent enzymes status were indicators of oxidative stress in erythrocytes of preeclamptic women.
AB  - Preeklampsija je sindrom specifičan za trudnoću sa visokim stepenom morbiditeta i mortaliteta fetusa i majke. Klinički se manifestuje posle 20. nedelje gestacije. Kod majke sindrom se manifestuje povišenim krvnim pritiskom i proteinurijom. Brojne savremene studije pokazuju da je disbalans oksidacionog i antioksidacionog sistema značajan faktor u patogenezi preeklampsije. Istraživanjem je obuhvaćeno 22 zdrave i 20 trudnica sa preeklampsijom. Dijagnoza preeklampsije je postavljena prema preporukama International Society for the Study of Hypertension in Pregnancy. U eritrocitima su praćeni sledeći parametri: koncentracija lipidnih peroksida (TBARS), neenzimskih komponenti (redukovani glutation - GSH, oksidovani glutation - GSSG) i aktivnost enzimskih komponenti AOS (glutation-peroksidaza, GSH-Px, glutation-reduktaza, GR i glutation-S-transferaza, GST). Rezultati ove studije pokazuju da je koncentracija TBARS i aktivnost GST značajno povećana, dok je aktivnost GR značajno smanjena u eritrocitima trudnica sa preeklampsijom u odnosu na zdrave trudnice. Koncentracije GSH i GSSG, kao i aktivnost GSH-Px nisu značajno promenjene. Povećanje koncentracije TBARS i aktivnosti GST, kao i poremećaj u GSH i GSH-zavisnom enzimskom statusu su indikatori oksidacionog stresa u eritrocitima trudnica sa preeklampsijom.
T2  - Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica
T1  - Antioksidacioni zaštitni sistem eritrocita u preeklampsiji
T1  - Antioxidative defense system of erythrocytes in preeclampsia
IS  - 3
VL  - 42
SP  - 227
EP  - 232
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_345
ER  - 

@article{
author = "Đorđević, Nataša Z. and Babić, Goran M. and Marković, Snežana D. and Ognjanović, Branka I. and Štajn, Andraš Š. and Žikić, Radoslav V. and Petrović, Vojislav M. and Saičić, Zorica",
year = "2006, 2006",
abstract = "Preeclampsia represents a pregnancy specific syndrome with high rate of both maternal and neonatal morbidity and mortality. The maternal syndrome is characterized by elevated arterial blood pressure and proteinuria. Several recent studies have reported that there is a disbalance of oxidant/antioxidant system in women with preeclampsia, and this factor might contribute to the pathogenesis of the disease. Our study involved 22 healthy (control) and 20 preeclamptic women. Diagnosis of preeclampsia was done according to the recommendation of International Society for the Study of Hypertension in Pregnancy. After blood collection, the next parameters were followed in erythrocytes: concentration of lipid peroxides (TBARS) non-enzymatic components (reduced glutathione - GSH, oxidized glutathione GSSG) and activities of enzymatic components of AOS (glutathione peroxidase GSH-Px, glutathione reductase - GR and glutathione-S-transferase - GST). Results of this study showed that concentration of TBARS and activity of GST were significantly higher, while activity of GR was significantly lower in erythrocytes of preeclamptic, vs. healthy women. Concentrations of GSH, GSSG and activity GSH-Px did not change significantly. Increased concentration of TBARS and activity of GST, as well as disorder in GSH and GSH-dependent enzymes status were indicators of oxidative stress in erythrocytes of preeclamptic women., Preeklampsija je sindrom specifičan za trudnoću sa visokim stepenom morbiditeta i mortaliteta fetusa i majke. Klinički se manifestuje posle 20. nedelje gestacije. Kod majke sindrom se manifestuje povišenim krvnim pritiskom i proteinurijom. Brojne savremene studije pokazuju da je disbalans oksidacionog i antioksidacionog sistema značajan faktor u patogenezi preeklampsije. Istraživanjem je obuhvaćeno 22 zdrave i 20 trudnica sa preeklampsijom. Dijagnoza preeklampsije je postavljena prema preporukama International Society for the Study of Hypertension in Pregnancy. U eritrocitima su praćeni sledeći parametri: koncentracija lipidnih peroksida (TBARS), neenzimskih komponenti (redukovani glutation - GSH, oksidovani glutation - GSSG) i aktivnost enzimskih komponenti AOS (glutation-peroksidaza, GSH-Px, glutation-reduktaza, GR i glutation-S-transferaza, GST). Rezultati ove studije pokazuju da je koncentracija TBARS i aktivnost GST značajno povećana, dok je aktivnost GR značajno smanjena u eritrocitima trudnica sa preeklampsijom u odnosu na zdrave trudnice. Koncentracije GSH i GSSG, kao i aktivnost GSH-Px nisu značajno promenjene. Povećanje koncentracije TBARS i aktivnosti GST, kao i poremećaj u GSH i GSH-zavisnom enzimskom statusu su indikatori oksidacionog stresa u eritrocitima trudnica sa preeklampsijom.",
journal = "Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica",
title = "Antioksidacioni zaštitni sistem eritrocita u preeklampsiji, Antioxidative defense system of erythrocytes in preeclampsia",
number = "3",
volume = "42",
pages = "227-232",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_345"
}

Đorđević, N. Z., Babić, G. M., Marković, S. D., Ognjanović, B. I., Štajn, A. Š., Žikić, R. V., Petrović, V. M.,& Saičić, Z.. (2006). Antioksidacioni zaštitni sistem eritrocita u preeklampsiji. in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica, 42(3), 227-232.
https://hdl.handle.net/21.15107/rcub_ibiss_345

Đorđević NZ, Babić GM, Marković SD, Ognjanović BI, Štajn AŠ, Žikić RV, Petrović VM, Saičić Z. Antioksidacioni zaštitni sistem eritrocita u preeklampsiji. in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica. 2006;42(3):227-232.
https://hdl.handle.net/21.15107/rcub_ibiss_345 .

Đorđević, Nataša Z., Babić, Goran M., Marković, Snežana D., Ognjanović, Branka I., Štajn, Andraš Š., Žikić, Radoslav V., Petrović, Vojislav M., Saičić, Zorica, "Antioksidacioni zaštitni sistem eritrocita u preeklampsiji" in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica, 42, no. 3 (2006):227-232,
https://hdl.handle.net/21.15107/rcub_ibiss_345 .

TY  - JOUR
AU  - Ognjanović, Branka I.
AU  - Marković, Snežana D.
AU  - Pavlović, Slađan
AU  - Žikić, Radoslav V.
AU  - Štajn, Andraš Š.
AU  - Saičić, Zorica
PY  - 2005
PY  - 2005
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/145
AB  - Cadmium (Cd+2) is an ubiquitous toxic metal that may induce oxidative damage by disturbing the prooxidant-antioxidant balance in the blood. Wistar albino rats (3 months old), were injected with a single dose of CdCh (0.4 mg Cd/kg i.p. and sacrificed after 24h). The hematological parameters: red blood cells count (RBCs), hematocrite (Ht) value and hemoglobin (Hb) concentration were significantly decreased in the blood of Cd treated rats. The activities of enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in plasma, as well as concentration of blood glucose were significantly increased in animals treated with cadmium in comparison to control values. The treatment with Cd increased lipid peroxidation (LP) and reduced glutathione (GSH) contents in the blood, suggesting that the Cd induced oxidative stress. These results of our study suggested that Cd induced alterations in hemato-biochemical parameters and LP and GSH content.
AB  - Kadmijum (Cd+2) je široko rasprostranjen toksičan metal koji može izazvati oksidaciona oštećenja u krvi remeteći prooksidaciono-antioksidacionu ravnotežu. Wistar albino pacovi (stari 3 meseca), tretirani su pojedinačnim dozama CdCl; (0.4 mg Cd/kg i.p) i žrtvovani posle 24 časa. Hematološki parametri, i to: broj eritrocita (RBCs), hematokritska vredno.st (Ht) i koncentracija hemoglobina (Hb) značajno su smanjeni u krvi tretiranih pacova. Aktivnost enzima alanin aminotransaminaze (ALT) i aspartat aminotransaminaze (AST) u plazmi, kao i koncentracija glukoze u krvi značajno su povećani kod životinja tretiranih kadmijumom u poređenju sa kontrolnim vrednostima. Tretman sa kadmijumom, takođe je doveo do povećanja lipidne peroksidacije (LP) i redukovanog glutationa (GSH). Sve to ukazuje da je kadmijum izazvao oksidacioni stres u krvi pacova. Dobijeni rezultati ukazuju da je Cd indukovao promené u hemato-biohemijskim parametrima, kao i u sadržaju LP i GSH u krvi tretiranih pacova.
T2  - Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta
T1  - Kadmijumom indukovane promene u hemato-biohemijskim parametrima, lipidnoj peroksidaciji i sadržaju glutationa u krvi pacova
T1  - Cadmium-induced changes in haemato-biochemical parameters, lipid peroxidation and glutathione content in blood of rats
IS  - 2
VL  - 41
SP  - 55
EP  - 64
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_145
ER  - 

@article{
author = "Ognjanović, Branka I. and Marković, Snežana D. and Pavlović, Slađan and Žikić, Radoslav V. and Štajn, Andraš Š. and Saičić, Zorica",
year = "2005, 2005",
abstract = "Cadmium (Cd+2) is an ubiquitous toxic metal that may induce oxidative damage by disturbing the prooxidant-antioxidant balance in the blood. Wistar albino rats (3 months old), were injected with a single dose of CdCh (0.4 mg Cd/kg i.p. and sacrificed after 24h). The hematological parameters: red blood cells count (RBCs), hematocrite (Ht) value and hemoglobin (Hb) concentration were significantly decreased in the blood of Cd treated rats. The activities of enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in plasma, as well as concentration of blood glucose were significantly increased in animals treated with cadmium in comparison to control values. The treatment with Cd increased lipid peroxidation (LP) and reduced glutathione (GSH) contents in the blood, suggesting that the Cd induced oxidative stress. These results of our study suggested that Cd induced alterations in hemato-biochemical parameters and LP and GSH content., Kadmijum (Cd+2) je široko rasprostranjen toksičan metal koji može izazvati oksidaciona oštećenja u krvi remeteći prooksidaciono-antioksidacionu ravnotežu. Wistar albino pacovi (stari 3 meseca), tretirani su pojedinačnim dozama CdCl; (0.4 mg Cd/kg i.p) i žrtvovani posle 24 časa. Hematološki parametri, i to: broj eritrocita (RBCs), hematokritska vredno.st (Ht) i koncentracija hemoglobina (Hb) značajno su smanjeni u krvi tretiranih pacova. Aktivnost enzima alanin aminotransaminaze (ALT) i aspartat aminotransaminaze (AST) u plazmi, kao i koncentracija glukoze u krvi značajno su povećani kod životinja tretiranih kadmijumom u poređenju sa kontrolnim vrednostima. Tretman sa kadmijumom, takođe je doveo do povećanja lipidne peroksidacije (LP) i redukovanog glutationa (GSH). Sve to ukazuje da je kadmijum izazvao oksidacioni stres u krvi pacova. Dobijeni rezultati ukazuju da je Cd indukovao promené u hemato-biohemijskim parametrima, kao i u sadržaju LP i GSH u krvi tretiranih pacova.",
journal = "Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta",
title = "Kadmijumom indukovane promene u hemato-biohemijskim parametrima, lipidnoj peroksidaciji i sadržaju glutationa u krvi pacova, Cadmium-induced changes in haemato-biochemical parameters, lipid peroxidation and glutathione content in blood of rats",
number = "2",
volume = "41",
pages = "55-64",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_145"
}

Ognjanović, B. I., Marković, S. D., Pavlović, S., Žikić, R. V., Štajn, A. Š.,& Saičić, Z.. (2005). Kadmijumom indukovane promene u hemato-biohemijskim parametrima, lipidnoj peroksidaciji i sadržaju glutationa u krvi pacova. in Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta, 41(2), 55-64.
https://hdl.handle.net/21.15107/rcub_ibiss_145

Ognjanović BI, Marković SD, Pavlović S, Žikić RV, Štajn AŠ, Saičić Z. Kadmijumom indukovane promene u hemato-biohemijskim parametrima, lipidnoj peroksidaciji i sadržaju glutationa u krvi pacova. in Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta. 2005;41(2):55-64.
https://hdl.handle.net/21.15107/rcub_ibiss_145 .

Ognjanović, Branka I., Marković, Snežana D., Pavlović, Slađan, Žikić, Radoslav V., Štajn, Andraš Š., Saičić, Zorica, "Kadmijumom indukovane promene u hemato-biohemijskim parametrima, lipidnoj peroksidaciji i sadržaju glutationa u krvi pacova" in Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta, 41, no. 2 (2005):55-64,
https://hdl.handle.net/21.15107/rcub_ibiss_145 .