TY  - JOUR
AU  - Matić, Miloš
AU  - Paunović, Milica
AU  - Ognjanović, Branka
AU  - Štajn, Andraš
AU  - Saičić, Zorica
PY  - 2017
UR  - internal-pdf://Matić et al. - 2016 - Neuropeptide Y reduces migration capacity of human choriocarcinoma cell line by altering oxidative antioxidative.pdf
UR  - http://online.journals.tubitak.gov.tr/openInPressDocument.htm?fileID=799024&no=150073&fileType=Report Document
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2614
AB  - Reduced migration capacity of trophoblast cells leads to poor placentation and correlates with severe pregnancy disorders such as intrauterine growth restriction and preeclampsia. Neuropeptide Y (NPY) is sympathetic cotransmitter involved in various physiological processes and its levels are significantly increased in preeclamptic pregnancy compared to healthy pregnancy. In this study the prooxidative role of NPY and its effects on migration capacity of human trophoblast cell line JEG-3 were investigated together with the effects of nitric oxide (NO) depletion, a molecule that was shown to play an important role in promoting cell migration. The cells were treated for 24 h (short-term stimulation) and 72 h (long-term stimulation) respectively with 1 nM NPY. Oxidative/antioxidative status and the migration index of cells were measured. The results showed increased concentrations of oxidative stress parameters (O2 •–, H2O2) and molecules of the antioxidant defense system (reduced glutathione and oxidized glutathione), while the levels of intracellular nitrites (indicators of NO) and cell migration index were significantly decreased in trophoblast cells treated with NPY (both at 24 h and 72 h of exposure) compared to the control cells. These results suggest that NPY may significantly contribute to reduced migration capacity of trophoblast cells by generating oxidative stress and reducing the bioavailability of NO.
T2  - Turkish Journal of Biology
T1  - Neuropeptide Y reduces migration capacity of human choriocarcinoma cell line by altering oxidative / antioxidative status
VL  - 41
DO  - 10.3906/biy-1606-73
SP  - 292
EP  - 301
ER  - 

@article{
author = "Matić, Miloš and Paunović, Milica and Ognjanović, Branka and Štajn, Andraš and Saičić, Zorica",
year = "2017",
abstract = "Reduced migration capacity of trophoblast cells leads to poor placentation and correlates with severe pregnancy disorders such as intrauterine growth restriction and preeclampsia. Neuropeptide Y (NPY) is sympathetic cotransmitter involved in various physiological processes and its levels are significantly increased in preeclamptic pregnancy compared to healthy pregnancy. In this study the prooxidative role of NPY and its effects on migration capacity of human trophoblast cell line JEG-3 were investigated together with the effects of nitric oxide (NO) depletion, a molecule that was shown to play an important role in promoting cell migration. The cells were treated for 24 h (short-term stimulation) and 72 h (long-term stimulation) respectively with 1 nM NPY. Oxidative/antioxidative status and the migration index of cells were measured. The results showed increased concentrations of oxidative stress parameters (O2 •–, H2O2) and molecules of the antioxidant defense system (reduced glutathione and oxidized glutathione), while the levels of intracellular nitrites (indicators of NO) and cell migration index were significantly decreased in trophoblast cells treated with NPY (both at 24 h and 72 h of exposure) compared to the control cells. These results suggest that NPY may significantly contribute to reduced migration capacity of trophoblast cells by generating oxidative stress and reducing the bioavailability of NO.",
journal = "Turkish Journal of Biology",
title = "Neuropeptide Y reduces migration capacity of human choriocarcinoma cell line by altering oxidative / antioxidative status",
volume = "41",
doi = "10.3906/biy-1606-73",
pages = "292-301"
}

Matić, M., Paunović, M., Ognjanović, B., Štajn, A.,& Saičić, Z.. (2017). Neuropeptide Y reduces migration capacity of human choriocarcinoma cell line by altering oxidative / antioxidative status. in Turkish Journal of Biology, 41, 292-301.
https://doi.org/10.3906/biy-1606-73

Matić M, Paunović M, Ognjanović B, Štajn A, Saičić Z. Neuropeptide Y reduces migration capacity of human choriocarcinoma cell line by altering oxidative / antioxidative status. in Turkish Journal of Biology. 2017;41:292-301.
doi:10.3906/biy-1606-73 .

Matić, Miloš, Paunović, Milica, Ognjanović, Branka, Štajn, Andraš, Saičić, Zorica, "Neuropeptide Y reduces migration capacity of human choriocarcinoma cell line by altering oxidative / antioxidative status" in Turkish Journal of Biology, 41 (2017):292-301,
https://doi.org/10.3906/biy-1606-73 . .

TY  - JOUR
AU  - Matić, Miloš
AU  - Paunović, Milica
AU  - Ognjanović, Branka
AU  - Štajn, Andraš
AU  - Saičić, Zorica
PY  - 2017
UR  - http://online.journals.tubitak.gov.tr/openInPressDocument.htm?fileID=799024&no=150073&fileType=Report Document
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2739
AB  - Reduced migration capacity of trophoblast cells leads to poor placentation and correlates with severe pregnancy disorders such as intrauterine growth restriction and preeclampsia. Neuropeptide Y (NPY) is sympathetic cotransmitter involved in various physiological processes and its levels are significantly increased in preeclamptic pregnancy compared to healthy pregnancy. In this study the prooxidative role of NPY and its effects on migration capacity of human trophoblast cell line JEG-3 were investigated together with the effects of nitric oxide (NO) depletion, a molecule that was shown to play an important role in promoting cell migration. The cells were treated for 24 h (short-term stimulation) and 72 h (long-term stimulation) respectively with 1 nM NPY. Oxidative/antioxidative status and the migration index of cells were measured. The results showed increased concentrations of oxidative stress parameters (O 2 •– , H 2 O 2 ) and molecules of the antioxidant defense system (reduced glutathione and oxidized glutathione), while the levels of intracellular nitrites (indicators of NO) and cell migration index were significantly decreased in trophoblast cells treated with NPY (both at 24 h and 72 h of exposure) compared to the control cells. These results suggest that NPY may significantly contribute to reduced migration capacity of trophoblast cells by generating oxidative stress and reducing the bioavailability of NO.
T2  - Turkish Journal of Biology
T1  - Neuropeptide Y reduces migration capacity of human choriocarcinoma cell line by altering oxidative / antioxidative status
IS  - 2
VL  - 41
DO  - 10.3906/biy-1606-73
SP  - 292
EP  - 301
ER  - 

@article{
author = "Matić, Miloš and Paunović, Milica and Ognjanović, Branka and Štajn, Andraš and Saičić, Zorica",
year = "2017",
abstract = "Reduced migration capacity of trophoblast cells leads to poor placentation and correlates with severe pregnancy disorders such as intrauterine growth restriction and preeclampsia. Neuropeptide Y (NPY) is sympathetic cotransmitter involved in various physiological processes and its levels are significantly increased in preeclamptic pregnancy compared to healthy pregnancy. In this study the prooxidative role of NPY and its effects on migration capacity of human trophoblast cell line JEG-3 were investigated together with the effects of nitric oxide (NO) depletion, a molecule that was shown to play an important role in promoting cell migration. The cells were treated for 24 h (short-term stimulation) and 72 h (long-term stimulation) respectively with 1 nM NPY. Oxidative/antioxidative status and the migration index of cells were measured. The results showed increased concentrations of oxidative stress parameters (O 2 •– , H 2 O 2 ) and molecules of the antioxidant defense system (reduced glutathione and oxidized glutathione), while the levels of intracellular nitrites (indicators of NO) and cell migration index were significantly decreased in trophoblast cells treated with NPY (both at 24 h and 72 h of exposure) compared to the control cells. These results suggest that NPY may significantly contribute to reduced migration capacity of trophoblast cells by generating oxidative stress and reducing the bioavailability of NO.",
journal = "Turkish Journal of Biology",
title = "Neuropeptide Y reduces migration capacity of human choriocarcinoma cell line by altering oxidative / antioxidative status",
number = "2",
volume = "41",
doi = "10.3906/biy-1606-73",
pages = "292-301"
}

Matić, M., Paunović, M., Ognjanović, B., Štajn, A.,& Saičić, Z.. (2017). Neuropeptide Y reduces migration capacity of human choriocarcinoma cell line by altering oxidative / antioxidative status. in Turkish Journal of Biology, 41(2), 292-301.
https://doi.org/10.3906/biy-1606-73

Matić M, Paunović M, Ognjanović B, Štajn A, Saičić Z. Neuropeptide Y reduces migration capacity of human choriocarcinoma cell line by altering oxidative / antioxidative status. in Turkish Journal of Biology. 2017;41(2):292-301.
doi:10.3906/biy-1606-73 .

Matić, Miloš, Paunović, Milica, Ognjanović, Branka, Štajn, Andraš, Saičić, Zorica, "Neuropeptide Y reduces migration capacity of human choriocarcinoma cell line by altering oxidative / antioxidative status" in Turkish Journal of Biology, 41, no. 2 (2017):292-301,
https://doi.org/10.3906/biy-1606-73 . .

TY  - JOUR
AU  - Gavrilović, Branka
AU  - Prokić, Marko
AU  - Gavrić, Jelena
AU  - Despotović, Svetlana
AU  - Radovanović, Tijana
AU  - Borković-Mitić, Slavica
AU  - Ognjanović, Branka
AU  - Pavlović, Slađan
AU  - Saičić, Zorica
PY  - 2016
UR  - internal-pdf://Gavrilović et al. - 2016 - Antioxidant Response in Gills of Eurasian Perch ( Perca fluviatilis ) to Cyanobacterial Bloom Exposure in the.pdf
UR  - http://www.wrmjournal.com/index.php?option=com_content&view=article&id=356&Itemid=291
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2615
AB  - The aim of this study was to assess the impact of an Aphanizomenon flos-aquae bloom in the Gruža Reservoir on the antioxidant parameters measured in the gill cells of Eurasian perch (Perca fluviatilis). Effects of the bloom were evaluated through copper, zinc and manganese containing superoxide dismutase (CuZnSOD and MnSOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR) and biotransformation phase II enzyme glutathione-S-transferase (GST) activities and glutathione (GSH) and sulfydryl (–SH) groups concentrations. The activities of CuZn SOD and Mn SOD decreased during the cyanobacterial bloom compared to the period before the bloom. The opposite trend was observed for CAT and GSH-Px activities that increased. During the bloom GR and GST activities and GSH concentration decreased significantly. CuZn SOD, GR and GST activities are detected as the most important parameters for individual variations. Our results indicated that an A. flos-aquae bloom promotes oxidative stress in the gills of P. fluviatilis. The investigated parameters could be used in environmental risk assessment procedures to monitor the effects of A. flos-aquae blooms on fish. Observed changes in the antioxidant parameters in P. fluviatilis gills make them potential biomarkers in the research of ecological risk situations in freshwater ecosystems with frequent cyanobacterial blooms.
T2  - Water Research and Management
T1  - Antioxidant Response in Gills of Eurasian Perch (Perca fluviatilis) to Cyanobacterial Bloom Exposure in the Gruža Reservoir
IS  - 2
VL  - 6
SP  - 19
EP  - 25
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_2615
ER  - 

@article{
author = "Gavrilović, Branka and Prokić, Marko and Gavrić, Jelena and Despotović, Svetlana and Radovanović, Tijana and Borković-Mitić, Slavica and Ognjanović, Branka and Pavlović, Slađan and Saičić, Zorica",
year = "2016",
abstract = "The aim of this study was to assess the impact of an Aphanizomenon flos-aquae bloom in the Gruža Reservoir on the antioxidant parameters measured in the gill cells of Eurasian perch (Perca fluviatilis). Effects of the bloom were evaluated through copper, zinc and manganese containing superoxide dismutase (CuZnSOD and MnSOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR) and biotransformation phase II enzyme glutathione-S-transferase (GST) activities and glutathione (GSH) and sulfydryl (–SH) groups concentrations. The activities of CuZn SOD and Mn SOD decreased during the cyanobacterial bloom compared to the period before the bloom. The opposite trend was observed for CAT and GSH-Px activities that increased. During the bloom GR and GST activities and GSH concentration decreased significantly. CuZn SOD, GR and GST activities are detected as the most important parameters for individual variations. Our results indicated that an A. flos-aquae bloom promotes oxidative stress in the gills of P. fluviatilis. The investigated parameters could be used in environmental risk assessment procedures to monitor the effects of A. flos-aquae blooms on fish. Observed changes in the antioxidant parameters in P. fluviatilis gills make them potential biomarkers in the research of ecological risk situations in freshwater ecosystems with frequent cyanobacterial blooms.",
journal = "Water Research and Management",
title = "Antioxidant Response in Gills of Eurasian Perch (Perca fluviatilis) to Cyanobacterial Bloom Exposure in the Gruža Reservoir",
number = "2",
volume = "6",
pages = "19-25",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_2615"
}

Gavrilović, B., Prokić, M., Gavrić, J., Despotović, S., Radovanović, T., Borković-Mitić, S., Ognjanović, B., Pavlović, S.,& Saičić, Z.. (2016). Antioxidant Response in Gills of Eurasian Perch (Perca fluviatilis) to Cyanobacterial Bloom Exposure in the Gruža Reservoir. in Water Research and Management, 6(2), 19-25.
https://hdl.handle.net/21.15107/rcub_ibiss_2615

Gavrilović B, Prokić M, Gavrić J, Despotović S, Radovanović T, Borković-Mitić S, Ognjanović B, Pavlović S, Saičić Z. Antioxidant Response in Gills of Eurasian Perch (Perca fluviatilis) to Cyanobacterial Bloom Exposure in the Gruža Reservoir. in Water Research and Management. 2016;6(2):19-25.
https://hdl.handle.net/21.15107/rcub_ibiss_2615 .

Gavrilović, Branka, Prokić, Marko, Gavrić, Jelena, Despotović, Svetlana, Radovanović, Tijana, Borković-Mitić, Slavica, Ognjanović, Branka, Pavlović, Slađan, Saičić, Zorica, "Antioxidant Response in Gills of Eurasian Perch (Perca fluviatilis) to Cyanobacterial Bloom Exposure in the Gruža Reservoir" in Water Research and Management, 6, no. 2 (2016):19-25,
https://hdl.handle.net/21.15107/rcub_ibiss_2615 .

TY  - CONF
AU  - Gavrilović, Branka
AU  - Despotović, Svetlana
AU  - Gavrić, Jelena
AU  - Radovanović, Tijana
AU  - Borković-Mitić, Slavica
AU  - Pavlović, Slađan
AU  - Simić, Snežana
AU  - Ognjanović, Branka
AU  - Pajović, Snežana
AU  - Saičić, Zorica
PY  - 2011
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5938
AB  - U našoj studiji istraživali smo promene aktivnosti enzima zaštite od oksidacionih oštećenja: ukupne superoksid-dismutaze (Uk SOD), bakar, cink sadržavajuće superoksid-dismutaze (CuZnSOD), mangan sadržavajuće superoksiddismutaze (MnSOD) i katalaze (CAT) u škrgama i mišiću slatkovodne ribe grgeča (Perca fluviatilis) kao odgovor na cvetanje cijanobakterije Aphanizomenon flos-aquae u Gružanskom jezeru. Takođe, ispitivana je koncentracija ukupnih proteina, kao i elektroforetska analiza proteina i SOD. Svi parametri određivani su tokom dva perioda, pre i za vreme cvetanja. Aktivnosti Uk SOD i MnSOD bile su niže i u škrgama i u mišiću, dok je aktivnost CuZnSOD pokazala niže vrednosti u mišiću za vreme cvetanja u odnosu na period pre cvetanja. Aktivnost CAT bila je značajno veća u oba ispitivana tkiva tokom cvetanja. U mišiću je zabeleženo statistički značajno povećanje koncentracije ukupnih proteina za vreme cvetanja, dok je elektroforetska analiza proteina ukazala na razlike u profilu proteina u škrgama i mišiću između dva ispitivana perioda. Elektroforetski profil enzima SOD pokazao je tipičan distribucioni obrazac SOD izoformi u oba tkiva. Naš rad predstavlja prvu studiju o uticaju cvetanja cijanobakterija na aktivnost enzima zaštite od oksidacionih oštećenja superoksid-dismutaze i katalaze u škrgama i mišiću slatkovodne ribe grgeča (Perca fluviatilis) iz Gružanskog jezera i ukazuje da cvetanje Aphanizomenon flos-aquae indukuje oksidacioni stres u ispitivanim tkivima. Ovo istraživanje daje osnovu za molekularno fiziološki biomonitoring uticaja cijanobakterija na različite slatkovodne organizme.
PB  - Beograd: Srpsko društvo za mitohondrijalnu i slobodno-radikalsku fiziologiju
C3  - Knjiga sažetaka: Prvi Kongres Mitohondrije i slobodni radikala - perspektive; 2011 Sep 24; Belgrade, Serbia
T1  - Promene aktivnosti superoksid-dismutaze i katalaze u nekim tkivima slatkovodne ribe grgeča (Perca fluviatilis) kao odgovor na cvetanje cijanobakterija u gružanskom jezeru
SP  - 41
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5938
ER  - 

@conference{
author = "Gavrilović, Branka and Despotović, Svetlana and Gavrić, Jelena and Radovanović, Tijana and Borković-Mitić, Slavica and Pavlović, Slađan and Simić, Snežana and Ognjanović, Branka and Pajović, Snežana and Saičić, Zorica",
year = "2011",
abstract = "U našoj studiji istraživali smo promene aktivnosti enzima zaštite od oksidacionih oštećenja: ukupne superoksid-dismutaze (Uk SOD), bakar, cink sadržavajuće superoksid-dismutaze (CuZnSOD), mangan sadržavajuće superoksiddismutaze (MnSOD) i katalaze (CAT) u škrgama i mišiću slatkovodne ribe grgeča (Perca fluviatilis) kao odgovor na cvetanje cijanobakterije Aphanizomenon flos-aquae u Gružanskom jezeru. Takođe, ispitivana je koncentracija ukupnih proteina, kao i elektroforetska analiza proteina i SOD. Svi parametri određivani su tokom dva perioda, pre i za vreme cvetanja. Aktivnosti Uk SOD i MnSOD bile su niže i u škrgama i u mišiću, dok je aktivnost CuZnSOD pokazala niže vrednosti u mišiću za vreme cvetanja u odnosu na period pre cvetanja. Aktivnost CAT bila je značajno veća u oba ispitivana tkiva tokom cvetanja. U mišiću je zabeleženo statistički značajno povećanje koncentracije ukupnih proteina za vreme cvetanja, dok je elektroforetska analiza proteina ukazala na razlike u profilu proteina u škrgama i mišiću između dva ispitivana perioda. Elektroforetski profil enzima SOD pokazao je tipičan distribucioni obrazac SOD izoformi u oba tkiva. Naš rad predstavlja prvu studiju o uticaju cvetanja cijanobakterija na aktivnost enzima zaštite od oksidacionih oštećenja superoksid-dismutaze i katalaze u škrgama i mišiću slatkovodne ribe grgeča (Perca fluviatilis) iz Gružanskog jezera i ukazuje da cvetanje Aphanizomenon flos-aquae indukuje oksidacioni stres u ispitivanim tkivima. Ovo istraživanje daje osnovu za molekularno fiziološki biomonitoring uticaja cijanobakterija na različite slatkovodne organizme.",
publisher = "Beograd: Srpsko društvo za mitohondrijalnu i slobodno-radikalsku fiziologiju",
journal = "Knjiga sažetaka: Prvi Kongres Mitohondrije i slobodni radikala - perspektive; 2011 Sep 24; Belgrade, Serbia",
title = "Promene aktivnosti superoksid-dismutaze i katalaze u nekim tkivima slatkovodne ribe grgeča (Perca fluviatilis) kao odgovor na cvetanje cijanobakterija u gružanskom jezeru",
pages = "41",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5938"
}

Gavrilović, B., Despotović, S., Gavrić, J., Radovanović, T., Borković-Mitić, S., Pavlović, S., Simić, S., Ognjanović, B., Pajović, S.,& Saičić, Z.. (2011). Promene aktivnosti superoksid-dismutaze i katalaze u nekim tkivima slatkovodne ribe grgeča (Perca fluviatilis) kao odgovor na cvetanje cijanobakterija u gružanskom jezeru. in Knjiga sažetaka: Prvi Kongres Mitohondrije i slobodni radikala - perspektive; 2011 Sep 24; Belgrade, Serbia
Beograd: Srpsko društvo za mitohondrijalnu i slobodno-radikalsku fiziologiju., 41.
https://hdl.handle.net/21.15107/rcub_ibiss_5938

Gavrilović B, Despotović S, Gavrić J, Radovanović T, Borković-Mitić S, Pavlović S, Simić S, Ognjanović B, Pajović S, Saičić Z. Promene aktivnosti superoksid-dismutaze i katalaze u nekim tkivima slatkovodne ribe grgeča (Perca fluviatilis) kao odgovor na cvetanje cijanobakterija u gružanskom jezeru. in Knjiga sažetaka: Prvi Kongres Mitohondrije i slobodni radikala - perspektive; 2011 Sep 24; Belgrade, Serbia. 2011;:41.
https://hdl.handle.net/21.15107/rcub_ibiss_5938 .

Gavrilović, Branka, Despotović, Svetlana, Gavrić, Jelena, Radovanović, Tijana, Borković-Mitić, Slavica, Pavlović, Slađan, Simić, Snežana, Ognjanović, Branka, Pajović, Snežana, Saičić, Zorica, "Promene aktivnosti superoksid-dismutaze i katalaze u nekim tkivima slatkovodne ribe grgeča (Perca fluviatilis) kao odgovor na cvetanje cijanobakterija u gružanskom jezeru" in Knjiga sažetaka: Prvi Kongres Mitohondrije i slobodni radikala - perspektive; 2011 Sep 24; Belgrade, Serbia (2011):41,
https://hdl.handle.net/21.15107/rcub_ibiss_5938 .

TY  - CONF
AU  - Gavrilović, Branka
AU  - Despotović, Svetlana
AU  - Radovanović, Tijana
AU  - Gavrić, Jelena
AU  - Borković-Mitić, Slavica
AU  - Pavlović, Slađan
AU  - Ognjanović, Branka
AU  - Pajović, Snežana
AU  - Saičić, Zorica
PY  - 2010
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5946
AB  - We investigated alterations of antioxidant defence system (ADS) in the liver of freshwater fish, European perch (Perea fluviatilis) as response to toxic Apha­ nizomenon flos-aquae bloom in the Gruza Reservoir. Activities of total, manga­ nese, copper zinc containing superoxide dismutase (Tot SOD, Mn SOD, CuZn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), phase II biotransformation enzyme glutathione S-transferase (GST), con­ centrations of total glutathione (GSH) and sulphydryl (-SH) groups were mea­ sured before and during bloom period. Histopathological examinations were studied using electron microscopy. Activities of CuZn SOD, CAT and GSH-Px and concentration of -SH groups were significantly lower, while Mn SOD activ­ ity was significantly higher during bloom period. No differences were observed for Tot SOD, GR and GST activities, as well as for GSH concentration. Electron microscopy showed alterations in hepatocytes, which results in damage of cells. Our work represents the first study of its kind and suggest on influence of toxic Aphanizomenon flos-aquae bloom in the Gruza Reservoir on ADS and on histo­ pathological changes in the liver of Perea fiuviatilis indicating on necrotic and apopototic damages of hepatocytes.
PB  - Belgrade: University of Belgrade, Faculty of Biology
C3  - Book of Abstracts: International Symposium One hunderd years of Ivan Djajać's (Jean Diaja) Belgrade School of Physiology; 2010 Sep 10-14; Belgrade, Serbia
T1  - Antioxidant defence responses to toxic cyanobacterial bloom in the liver of freshwater fish, Perca fluviatilis from the Gruža reservoir
SP  - 112
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5946
ER  - 

@conference{
author = "Gavrilović, Branka and Despotović, Svetlana and Radovanović, Tijana and Gavrić, Jelena and Borković-Mitić, Slavica and Pavlović, Slađan and Ognjanović, Branka and Pajović, Snežana and Saičić, Zorica",
year = "2010",
abstract = "We investigated alterations of antioxidant defence system (ADS) in the liver of freshwater fish, European perch (Perea fluviatilis) as response to toxic Apha­ nizomenon flos-aquae bloom in the Gruza Reservoir. Activities of total, manga­ nese, copper zinc containing superoxide dismutase (Tot SOD, Mn SOD, CuZn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), phase II biotransformation enzyme glutathione S-transferase (GST), con­ centrations of total glutathione (GSH) and sulphydryl (-SH) groups were mea­ sured before and during bloom period. Histopathological examinations were studied using electron microscopy. Activities of CuZn SOD, CAT and GSH-Px and concentration of -SH groups were significantly lower, while Mn SOD activ­ ity was significantly higher during bloom period. No differences were observed for Tot SOD, GR and GST activities, as well as for GSH concentration. Electron microscopy showed alterations in hepatocytes, which results in damage of cells. Our work represents the first study of its kind and suggest on influence of toxic Aphanizomenon flos-aquae bloom in the Gruza Reservoir on ADS and on histo­ pathological changes in the liver of Perea fiuviatilis indicating on necrotic and apopototic damages of hepatocytes.",
publisher = "Belgrade: University of Belgrade, Faculty of Biology",
journal = "Book of Abstracts: International Symposium One hunderd years of Ivan Djajać's (Jean Diaja) Belgrade School of Physiology; 2010 Sep 10-14; Belgrade, Serbia",
title = "Antioxidant defence responses to toxic cyanobacterial bloom in the liver of freshwater fish, Perca fluviatilis from the Gruža reservoir",
pages = "112",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5946"
}

Gavrilović, B., Despotović, S., Radovanović, T., Gavrić, J., Borković-Mitić, S., Pavlović, S., Ognjanović, B., Pajović, S.,& Saičić, Z.. (2010). Antioxidant defence responses to toxic cyanobacterial bloom in the liver of freshwater fish, Perca fluviatilis from the Gruža reservoir. in Book of Abstracts: International Symposium One hunderd years of Ivan Djajać's (Jean Diaja) Belgrade School of Physiology; 2010 Sep 10-14; Belgrade, Serbia
Belgrade: University of Belgrade, Faculty of Biology., 112.
https://hdl.handle.net/21.15107/rcub_ibiss_5946

Gavrilović B, Despotović S, Radovanović T, Gavrić J, Borković-Mitić S, Pavlović S, Ognjanović B, Pajović S, Saičić Z. Antioxidant defence responses to toxic cyanobacterial bloom in the liver of freshwater fish, Perca fluviatilis from the Gruža reservoir. in Book of Abstracts: International Symposium One hunderd years of Ivan Djajać's (Jean Diaja) Belgrade School of Physiology; 2010 Sep 10-14; Belgrade, Serbia. 2010;:112.
https://hdl.handle.net/21.15107/rcub_ibiss_5946 .

Gavrilović, Branka, Despotović, Svetlana, Radovanović, Tijana, Gavrić, Jelena, Borković-Mitić, Slavica, Pavlović, Slađan, Ognjanović, Branka, Pajović, Snežana, Saičić, Zorica, "Antioxidant defence responses to toxic cyanobacterial bloom in the liver of freshwater fish, Perca fluviatilis from the Gruža reservoir" in Book of Abstracts: International Symposium One hunderd years of Ivan Djajać's (Jean Diaja) Belgrade School of Physiology; 2010 Sep 10-14; Belgrade, Serbia (2010):112,
https://hdl.handle.net/21.15107/rcub_ibiss_5946 .

TY  - CONF
AU  - Ognjanović, Branka
AU  - Marković, Snežana
AU  - Đorđević, Nataša
AU  - Pavlović, Slađan
AU  - Štajn, Andraš Š.
AU  - Žikić, Radoslav V.
AU  - Saičić, Zorica
PY  - 2007
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5999
AB  - The environment is continuously loaded with foreign organic chemicals (xenobiotics) released by urban communities and industries. Many classes of environmental contaminants (or their metabolites) are know to enhance the intracellular formation of reactive oxygen species (ROS) causing oxidative damage to biological systems. Fish are the most important organisms used in biomonitoring of aquatic ecosystems. Parameters of oxidative stress in fish tissues represent significant biomarkers in the assessment of the status of environment.
Specimens two marine fishes of hake (Merluccius merluccius L.) and red mullet (Mullus barbatus L.) were collected May 2005 from the locality in front of sea-port Bar (South Adriatic Sea). Parameters of oxidative stress: activity of antioxidative enzymes (superoxide dismutase­ SOD and catalase-CAT) and concentration of lipid peroxidation-LP and glutathione-GSH were determined in the liver of hake and red mullet.
Obtained results showed that activities of SOD and CAT were significantly lower in the liver of hake than in red mullet. Higher concentrations of LP and GSH in liver of hake were recorded, due to changes ofphysical­ chemical parameters of environment. The intensity of oxidative stress in liver of hake was higher in comparison to red mullet. This increased ROS production and subsequent oxidati e damage has been associated with pollutant mediated mechanism of toxicity in liver of investigated fishes.
According to the analyses of our results the investigated parameters of oxidative stress (concentration of LP and GSH, as well as activity of antioxidative enzymes SOD and CAT) in liver of hake and red mullet demonstrate     significant     and     reliable     biomarkers     m  monitoring,environmental  pollution.
PB  - Novi Sad: Faculty of Sciences, Department of Biology and Ecology
C3  - Collection of abstracts: 1st International Congress on Biology in Serbia: Kobis 2007; 2007 Oct 25-28; Palić, Serbia
T1  - Oxidative stress parameters in the liver of hake (Merluccius merluccius L.) and red mullet (Mullus barbatus L.) from the Adriatic sea
SP  - 69
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5999
ER  - 

@conference{
author = "Ognjanović, Branka and Marković, Snežana and Đorđević, Nataša and Pavlović, Slađan and Štajn, Andraš Š. and Žikić, Radoslav V. and Saičić, Zorica",
year = "2007",
abstract = "The environment is continuously loaded with foreign organic chemicals (xenobiotics) released by urban communities and industries. Many classes of environmental contaminants (or their metabolites) are know to enhance the intracellular formation of reactive oxygen species (ROS) causing oxidative damage to biological systems. Fish are the most important organisms used in biomonitoring of aquatic ecosystems. Parameters of oxidative stress in fish tissues represent significant biomarkers in the assessment of the status of environment.
Specimens two marine fishes of hake (Merluccius merluccius L.) and red mullet (Mullus barbatus L.) were collected May 2005 from the locality in front of sea-port Bar (South Adriatic Sea). Parameters of oxidative stress: activity of antioxidative enzymes (superoxide dismutase­ SOD and catalase-CAT) and concentration of lipid peroxidation-LP and glutathione-GSH were determined in the liver of hake and red mullet.
Obtained results showed that activities of SOD and CAT were significantly lower in the liver of hake than in red mullet. Higher concentrations of LP and GSH in liver of hake were recorded, due to changes ofphysical­ chemical parameters of environment. The intensity of oxidative stress in liver of hake was higher in comparison to red mullet. This increased ROS production and subsequent oxidati e damage has been associated with pollutant mediated mechanism of toxicity in liver of investigated fishes.
According to the analyses of our results the investigated parameters of oxidative stress (concentration of LP and GSH, as well as activity of antioxidative enzymes SOD and CAT) in liver of hake and red mullet demonstrate     significant     and     reliable     biomarkers     m  monitoring,environmental  pollution.",
publisher = "Novi Sad: Faculty of Sciences, Department of Biology and Ecology",
journal = "Collection of abstracts: 1st International Congress on Biology in Serbia: Kobis 2007; 2007 Oct 25-28; Palić, Serbia",
title = "Oxidative stress parameters in the liver of hake (Merluccius merluccius L.) and red mullet (Mullus barbatus L.) from the Adriatic sea",
pages = "69",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5999"
}

Ognjanović, B., Marković, S., Đorđević, N., Pavlović, S., Štajn, A. Š., Žikić, R. V.,& Saičić, Z.. (2007). Oxidative stress parameters in the liver of hake (Merluccius merluccius L.) and red mullet (Mullus barbatus L.) from the Adriatic sea. in Collection of abstracts: 1st International Congress on Biology in Serbia: Kobis 2007; 2007 Oct 25-28; Palić, Serbia
Novi Sad: Faculty of Sciences, Department of Biology and Ecology., 69.
https://hdl.handle.net/21.15107/rcub_ibiss_5999

Ognjanović B, Marković S, Đorđević N, Pavlović S, Štajn AŠ, Žikić RV, Saičić Z. Oxidative stress parameters in the liver of hake (Merluccius merluccius L.) and red mullet (Mullus barbatus L.) from the Adriatic sea. in Collection of abstracts: 1st International Congress on Biology in Serbia: Kobis 2007; 2007 Oct 25-28; Palić, Serbia. 2007;:69.
https://hdl.handle.net/21.15107/rcub_ibiss_5999 .

Ognjanović, Branka, Marković, Snežana, Đorđević, Nataša, Pavlović, Slađan, Štajn, Andraš Š., Žikić, Radoslav V., Saičić, Zorica, "Oxidative stress parameters in the liver of hake (Merluccius merluccius L.) and red mullet (Mullus barbatus L.) from the Adriatic sea" in Collection of abstracts: 1st International Congress on Biology in Serbia: Kobis 2007; 2007 Oct 25-28; Palić, Serbia (2007):69,
https://hdl.handle.net/21.15107/rcub_ibiss_5999 .

TY  - CONF
AU  - Đorđević, Nataša
AU  - Ognjanović, Branka
AU  - Marković, Snežana
AU  - Pavlović, Slađan
AU  - Žikić, Radoslav V.
AU  - Štajn, Andraš Š.
AU  - Saičić, Zorica
PY  - 2007
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5998
AB  - Recent investigations in biomonitoring include the monitoring of biochemical and physiological parameters to evaluate the condition of environment. Parameters of oxidative stress are significant biomarkers of environmental pollution of the sea. Specimens of marine fish - hake (Merluccius merluccius) was collected from the localities of Platamuni and Valdanos (Sauth Adriatic) in winter   and   spring   during   2003   year.   Concentrations   of antioxidant compounds such as Vitamin E (Vit E) and Vitamin C (Vit C) as well as, lipid peroxidation (LP) were determined in the liver and white muscle of the hake. Physical chemical parameters of water of investigated  localities  were also determined: salinity, temperature, oxygen saturation and concentrations of nitrites, nitrates and detergent in both seasons.
The obtained results showed higher concentrations of LP, Vit E and Vit C in liver of hake in comparison to white muscle. Concentrations of LP and Vit C were increased, while the concentrations of Vit E were decreased in winter period in comparison to spring. Concentrations of LP were increased while the concentrations of Vit E were decreased in both investigated tissues of hake from the waters of locality Valdanos in respect to Platamuni. These changes of parameters of oxidative stress are, in part, the consequence of changes of temperature as well as, concentrations of nitrites, nitrates and detergents in water of investigated localities and in particular season.
In conclusion, the concentrations of parameter of oxidative stress in investigated tissues of hake represent a good marker in the biomonitoring of environmental pollution. The intensity of oxidative stress was increased in the liver of hake in comparison to white muscle, in winter period ill respect to spring and in waters of Valdanos in comparison to Platamuni
PB  - Novi Sad: Faculty of Sciences, Department of Biology and Ecology
C3  - Collection of abstracts: 1st International Congress on Biology in Serbia: Kobis 2007; 2007 Oct 25-28; Palić, Serbia
T1  - Concentration of antioxidant compounds and lipid peroxidation in some tissues of hake (Merluccius merluccius L.) from the Adriatic sea
SP  - 55
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5998
ER  - 

@conference{
author = "Đorđević, Nataša and Ognjanović, Branka and Marković, Snežana and Pavlović, Slađan and Žikić, Radoslav V. and Štajn, Andraš Š. and Saičić, Zorica",
year = "2007",
abstract = "Recent investigations in biomonitoring include the monitoring of biochemical and physiological parameters to evaluate the condition of environment. Parameters of oxidative stress are significant biomarkers of environmental pollution of the sea. Specimens of marine fish - hake (Merluccius merluccius) was collected from the localities of Platamuni and Valdanos (Sauth Adriatic) in winter   and   spring   during   2003   year.   Concentrations   of antioxidant compounds such as Vitamin E (Vit E) and Vitamin C (Vit C) as well as, lipid peroxidation (LP) were determined in the liver and white muscle of the hake. Physical chemical parameters of water of investigated  localities  were also determined: salinity, temperature, oxygen saturation and concentrations of nitrites, nitrates and detergent in both seasons.
The obtained results showed higher concentrations of LP, Vit E and Vit C in liver of hake in comparison to white muscle. Concentrations of LP and Vit C were increased, while the concentrations of Vit E were decreased in winter period in comparison to spring. Concentrations of LP were increased while the concentrations of Vit E were decreased in both investigated tissues of hake from the waters of locality Valdanos in respect to Platamuni. These changes of parameters of oxidative stress are, in part, the consequence of changes of temperature as well as, concentrations of nitrites, nitrates and detergents in water of investigated localities and in particular season.
In conclusion, the concentrations of parameter of oxidative stress in investigated tissues of hake represent a good marker in the biomonitoring of environmental pollution. The intensity of oxidative stress was increased in the liver of hake in comparison to white muscle, in winter period ill respect to spring and in waters of Valdanos in comparison to Platamuni",
publisher = "Novi Sad: Faculty of Sciences, Department of Biology and Ecology",
journal = "Collection of abstracts: 1st International Congress on Biology in Serbia: Kobis 2007; 2007 Oct 25-28; Palić, Serbia",
title = "Concentration of antioxidant compounds and lipid peroxidation in some tissues of hake (Merluccius merluccius L.) from the Adriatic sea",
pages = "55",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5998"
}

Đorđević, N., Ognjanović, B., Marković, S., Pavlović, S., Žikić, R. V., Štajn, A. Š.,& Saičić, Z.. (2007). Concentration of antioxidant compounds and lipid peroxidation in some tissues of hake (Merluccius merluccius L.) from the Adriatic sea. in Collection of abstracts: 1st International Congress on Biology in Serbia: Kobis 2007; 2007 Oct 25-28; Palić, Serbia
Novi Sad: Faculty of Sciences, Department of Biology and Ecology., 55.
https://hdl.handle.net/21.15107/rcub_ibiss_5998

Đorđević N, Ognjanović B, Marković S, Pavlović S, Žikić RV, Štajn AŠ, Saičić Z. Concentration of antioxidant compounds and lipid peroxidation in some tissues of hake (Merluccius merluccius L.) from the Adriatic sea. in Collection of abstracts: 1st International Congress on Biology in Serbia: Kobis 2007; 2007 Oct 25-28; Palić, Serbia. 2007;:55.
https://hdl.handle.net/21.15107/rcub_ibiss_5998 .

Đorđević, Nataša, Ognjanović, Branka, Marković, Snežana, Pavlović, Slađan, Žikić, Radoslav V., Štajn, Andraš Š., Saičić, Zorica, "Concentration of antioxidant compounds and lipid peroxidation in some tissues of hake (Merluccius merluccius L.) from the Adriatic sea" in Collection of abstracts: 1st International Congress on Biology in Serbia: Kobis 2007; 2007 Oct 25-28; Palić, Serbia (2007):55,
https://hdl.handle.net/21.15107/rcub_ibiss_5998 .

TY  - CONF
AU  - Ognjanović, Branka
AU  - Marković, Snežana
AU  - Pavlović, Slađan
AU  - Žikić, Radoslav V.
AU  - Štajn, Andraš Š.
AU  - Saičić, Zorica
PY  - 2007
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5971
AB  - Cadmium (Cd) is  an  ubiquitous,  nonessential  element  that  has  recentl y  raised concerns due to its accumulation in the environment. The toxicity of Cd as an industrial  pollutant  a  food  contaminant and  as  one  of  the  major  components   in  cigarette smoke has been well established. A number of nutrient s have been shown to interact with Cd and alter its cellular effects. Several protective agents, including conzyme Q10 (CoQ10) and vitamin E (Vit E) play an important role in detoxification of  endogenous  and  exogenous  compounds.  Our  study  investigated  the possible protective  effects  of  coenzyme Q10  (CoQ 10)  and  vitamin   E  (Vit  E)  alone  or  in cornbrnation against cadmium (Cd) induced alterations of antioxidant defense system  in the rat heart. Male Wistar rats were injected with a single dose of CdCl2 (0.4 mg Cd/kg  i.p.),  CoQ10 (20  mg CoQ 1 0/kg  i. m.) and  Vit E (20  lU  Vit  E/kg, i. m.), a lone or in combination. Acute  intoxication  of  rats with Cd  were followed  by significantly  increased activity of antioxidant defense enzymes (CuZn SOD, GSH-Px, GST and GR), while the activity of Mn SOD  was decreased in the heart. The treatment with Cd significantly decreased Vit C and Vit E concentrations . Treatment with CoQ10+Vit E reversed  Cd-induced  alterations  in Vit C and  Vit  E concentrations. Our study suggests that the prooxidative effect of Cd is respon si ble for  alterations in prooxidant-ant ioxidant balance in the heart. The obtained results support the assumption   that   CoQ10  and Vit E functions   cooperatively with endogenous antioxidants and diminished some toxic effects of Cd in rat hearts .
PB  - Belgrade: Serbian Physiology Society
C3  - Abstract book: A Scientific Conference with International Participation: Nutrition, Treatment and Cardiovascular Risk Management; 2007 May 24-27; Novi Sad, Serbia
T1  - Antioxidant effect of coenzyme Q10 and vitamin E in Cadmium induced alterations of antioxidant defense system in the rat heart.
SP  - 112
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5971
ER  - 

@conference{
author = "Ognjanović, Branka and Marković, Snežana and Pavlović, Slađan and Žikić, Radoslav V. and Štajn, Andraš Š. and Saičić, Zorica",
year = "2007",
abstract = "Cadmium (Cd) is  an  ubiquitous,  nonessential  element  that  has  recentl y  raised concerns due to its accumulation in the environment. The toxicity of Cd as an industrial  pollutant  a  food  contaminant and  as  one  of  the  major  components   in  cigarette smoke has been well established. A number of nutrient s have been shown to interact with Cd and alter its cellular effects. Several protective agents, including conzyme Q10 (CoQ10) and vitamin E (Vit E) play an important role in detoxification of  endogenous  and  exogenous  compounds.  Our  study  investigated  the possible protective  effects  of  coenzyme Q10  (CoQ 10)  and  vitamin   E  (Vit  E)  alone  or  in cornbrnation against cadmium (Cd) induced alterations of antioxidant defense system  in the rat heart. Male Wistar rats were injected with a single dose of CdCl2 (0.4 mg Cd/kg  i.p.),  CoQ10 (20  mg CoQ 1 0/kg  i. m.) and  Vit E (20  lU  Vit  E/kg, i. m.), a lone or in combination. Acute  intoxication  of  rats with Cd  were followed  by significantly  increased activity of antioxidant defense enzymes (CuZn SOD, GSH-Px, GST and GR), while the activity of Mn SOD  was decreased in the heart. The treatment with Cd significantly decreased Vit C and Vit E concentrations . Treatment with CoQ10+Vit E reversed  Cd-induced  alterations  in Vit C and  Vit  E concentrations. Our study suggests that the prooxidative effect of Cd is respon si ble for  alterations in prooxidant-ant ioxidant balance in the heart. The obtained results support the assumption   that   CoQ10  and Vit E functions   cooperatively with endogenous antioxidants and diminished some toxic effects of Cd in rat hearts .",
publisher = "Belgrade: Serbian Physiology Society",
journal = "Abstract book: A Scientific Conference with International Participation: Nutrition, Treatment and Cardiovascular Risk Management; 2007 May 24-27; Novi Sad, Serbia",
title = "Antioxidant effect of coenzyme Q10 and vitamin E in Cadmium induced alterations of antioxidant defense system in the rat heart.",
pages = "112",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5971"
}

Ognjanović, B., Marković, S., Pavlović, S., Žikić, R. V., Štajn, A. Š.,& Saičić, Z.. (2007). Antioxidant effect of coenzyme Q10 and vitamin E in Cadmium induced alterations of antioxidant defense system in the rat heart.. in Abstract book: A Scientific Conference with International Participation: Nutrition, Treatment and Cardiovascular Risk Management; 2007 May 24-27; Novi Sad, Serbia
Belgrade: Serbian Physiology Society., 112.
https://hdl.handle.net/21.15107/rcub_ibiss_5971

Ognjanović B, Marković S, Pavlović S, Žikić RV, Štajn AŠ, Saičić Z. Antioxidant effect of coenzyme Q10 and vitamin E in Cadmium induced alterations of antioxidant defense system in the rat heart.. in Abstract book: A Scientific Conference with International Participation: Nutrition, Treatment and Cardiovascular Risk Management; 2007 May 24-27; Novi Sad, Serbia. 2007;:112.
https://hdl.handle.net/21.15107/rcub_ibiss_5971 .

Ognjanović, Branka, Marković, Snežana, Pavlović, Slađan, Žikić, Radoslav V., Štajn, Andraš Š., Saičić, Zorica, "Antioxidant effect of coenzyme Q10 and vitamin E in Cadmium induced alterations of antioxidant defense system in the rat heart." in Abstract book: A Scientific Conference with International Participation: Nutrition, Treatment and Cardiovascular Risk Management; 2007 May 24-27; Novi Sad, Serbia (2007):112,
https://hdl.handle.net/21.15107/rcub_ibiss_5971 .

TY  - CONF
AU  - Pavlović, Slađan
AU  - Ognjanović, Branka
AU  - Štajn, Andraš Š.
AU  - Žikić, Radoslav V.
AU  - Saičić, Zorica
PY  - 2006
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5969
AB  - Cadmium (Cd) is a commonly occurring environmental contaminant which after being intake into the organism accumulates mostly in the liver and kidneys. Recent studies on mammals have shown that Cd stimulates formation of superoxide anion radicals, hydrogen peroxide and hydroxyl radicals. As a consequence, enhanced lipid peroxidation, DNA damage, altered calcium and sulfhydryl homeostasis, as well as marked disturbances of antioxidant defense system occur.
Coenzyme Q10 (CoQ10) in its reduced form (CoQ10H2) is a powerful antioxidant. As an antioxidant it is exploited either directly upon superoxide or indirectly on lipid radicals. CoQ10 may prevent both the initiation and propagation of lipid peroxidation, protects DNA from oxidation causing by lipid peroxidation and protects organism from oxidative stress induced by various toxic agents. 
	The activities of Total SOD, Mn SOD, CuZn SOD, CAT, GSH-Px, GR and phase II biotransformation enzyme-GST, as well as Vit C and Vit E concentrations were analyzed in the liver, heart and kidneys of male, two months old Wistar albino rats treated with Cd (200 mg CdCl2 x H2O, in drinking water during 30 days), CoQ10 (20 mg/kg CoQ10 dissolved in olive oil, i.m., every fifth day), concomitantly treated with Cd and CoQ10 (200 mg CdCl2 x H2O, in drinking water during 30 days + 20 mg/kg CoQ10 dissolved in olive oil, i.m., every fifth day) and in control animals (C). 
	 This study suggested that Cd influences antioxidative defense enzyme activities in the liver, heart and kidneys of rats in various ways, especially depending on its metabolic activity. CoQ10 only partially (and tissue-specific) reversed Cd-induced changes on these enzymes. At the same time, CoQ10 exerts very strong beneficial effects on Vit C and Vit E by elevating its concentrations and thus induced an increase in antioxidative defense potential in investigated tissues of rats treated with Cd.
PB  - Belgrade: Serbian Physiology Society
C3  - Abstract book: The 2nd Multidisciplinary Scientific Meeting with International participation: Oxidative Stress and the Mechanisms of Protection; 2006 Nov 2-3; Kragujevac, Serbia
T1  - Effect of cadmium on antioxidant defense system: changes after co-treatment with coenzyme Q10 in some tissues of rats.
SP  - 33
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5969
ER  - 

@conference{
author = "Pavlović, Slađan and Ognjanović, Branka and Štajn, Andraš Š. and Žikić, Radoslav V. and Saičić, Zorica",
year = "2006",
abstract = "Cadmium (Cd) is a commonly occurring environmental contaminant which after being intake into the organism accumulates mostly in the liver and kidneys. Recent studies on mammals have shown that Cd stimulates formation of superoxide anion radicals, hydrogen peroxide and hydroxyl radicals. As a consequence, enhanced lipid peroxidation, DNA damage, altered calcium and sulfhydryl homeostasis, as well as marked disturbances of antioxidant defense system occur.
Coenzyme Q10 (CoQ10) in its reduced form (CoQ10H2) is a powerful antioxidant. As an antioxidant it is exploited either directly upon superoxide or indirectly on lipid radicals. CoQ10 may prevent both the initiation and propagation of lipid peroxidation, protects DNA from oxidation causing by lipid peroxidation and protects organism from oxidative stress induced by various toxic agents. 
	The activities of Total SOD, Mn SOD, CuZn SOD, CAT, GSH-Px, GR and phase II biotransformation enzyme-GST, as well as Vit C and Vit E concentrations were analyzed in the liver, heart and kidneys of male, two months old Wistar albino rats treated with Cd (200 mg CdCl2 x H2O, in drinking water during 30 days), CoQ10 (20 mg/kg CoQ10 dissolved in olive oil, i.m., every fifth day), concomitantly treated with Cd and CoQ10 (200 mg CdCl2 x H2O, in drinking water during 30 days + 20 mg/kg CoQ10 dissolved in olive oil, i.m., every fifth day) and in control animals (C). 
	 This study suggested that Cd influences antioxidative defense enzyme activities in the liver, heart and kidneys of rats in various ways, especially depending on its metabolic activity. CoQ10 only partially (and tissue-specific) reversed Cd-induced changes on these enzymes. At the same time, CoQ10 exerts very strong beneficial effects on Vit C and Vit E by elevating its concentrations and thus induced an increase in antioxidative defense potential in investigated tissues of rats treated with Cd.",
publisher = "Belgrade: Serbian Physiology Society",
journal = "Abstract book: The 2nd Multidisciplinary Scientific Meeting with International participation: Oxidative Stress and the Mechanisms of Protection; 2006 Nov 2-3; Kragujevac, Serbia",
title = "Effect of cadmium on antioxidant defense system: changes after co-treatment with coenzyme Q10 in some tissues of rats.",
pages = "33",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5969"
}

Pavlović, S., Ognjanović, B., Štajn, A. Š., Žikić, R. V.,& Saičić, Z.. (2006). Effect of cadmium on antioxidant defense system: changes after co-treatment with coenzyme Q10 in some tissues of rats.. in Abstract book: The 2nd Multidisciplinary Scientific Meeting with International participation: Oxidative Stress and the Mechanisms of Protection; 2006 Nov 2-3; Kragujevac, Serbia
Belgrade: Serbian Physiology Society., 33.
https://hdl.handle.net/21.15107/rcub_ibiss_5969

Pavlović S, Ognjanović B, Štajn AŠ, Žikić RV, Saičić Z. Effect of cadmium on antioxidant defense system: changes after co-treatment with coenzyme Q10 in some tissues of rats.. in Abstract book: The 2nd Multidisciplinary Scientific Meeting with International participation: Oxidative Stress and the Mechanisms of Protection; 2006 Nov 2-3; Kragujevac, Serbia. 2006;:33.
https://hdl.handle.net/21.15107/rcub_ibiss_5969 .

Pavlović, Slađan, Ognjanović, Branka, Štajn, Andraš Š., Žikić, Radoslav V., Saičić, Zorica, "Effect of cadmium on antioxidant defense system: changes after co-treatment with coenzyme Q10 in some tissues of rats." in Abstract book: The 2nd Multidisciplinary Scientific Meeting with International participation: Oxidative Stress and the Mechanisms of Protection; 2006 Nov 2-3; Kragujevac, Serbia (2006):33,
https://hdl.handle.net/21.15107/rcub_ibiss_5969 .

TY  - CONF
AU  - Ognjanović, Branka
AU  - Filipović, Jasmina
AU  - Nikolić, Dubravka
AU  - Marković, Snežana
AU  - Pavlović, Slađan
AU  - Žikić, Radoslav V.
AU  - Štajn, Andraš Š.
AU  - Saičić, Zorica
PY  - 2006
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5966
AB  - Fish are the most important organisms used in biomonitoring of aquatic ecosystems.Parameters of oxidative stress in fish tissues represent significant biomarkers in theassessment of the status of environment. Specimens of hake (Merluccius merluccius L.) andsea bream (Pagellus erythrinus L.) were collected at the end of May 2005 from the locality infront of sea-port Bar (South Adriatic Sea). Parameters of oxidative stress (concentration oflipid peroxidase – LP and reduced glutathione – GSH) were determined in the liver and whitemuscle of hake and sea bream. Physical-chemical parameters (salinity, concentration ofdissolved oxygen and temperature) were determined in water of the investigated locality.Obtained results showed that the concentration of LP was higher in liver of hake and seabream in comparison to white muscle. However, significantly higher concentration of GSHwas found in white muscle of hake and sea bream in comparison to liver. These changes ofoxidative stress parameters point to tissue specificity, which is the consequence of differentmetabolic and antioxidative activity. Inter-specific differences were also established. Higherconcentrations of LP and GSH in liver of hake and in white muscle of sea bream wererecorded, due to changes of physical-chemical parameters of environment. The intensity ofoxidative stress in liver of hake and sea bream was higher in comparison to muscle.
PB  - Podgorica: Centre for Biodiversity of Montenegro
C3  - The Book of Abstracts and Programme: II International Symposium of Ecologists of Montenegro ISEM2; 2006 Sep 20-24; Kotor, Montenegro
T1  - Lipid peroxidation and glutathione content in tissues of hake (Merluccius merluccius L.) and sea bream (Pagellus erythrinus L.) from the Adriatic sea
SP  - 91
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5966
ER  - 

@conference{
author = "Ognjanović, Branka and Filipović, Jasmina and Nikolić, Dubravka and Marković, Snežana and Pavlović, Slađan and Žikić, Radoslav V. and Štajn, Andraš Š. and Saičić, Zorica",
year = "2006",
abstract = "Fish are the most important organisms used in biomonitoring of aquatic ecosystems.Parameters of oxidative stress in fish tissues represent significant biomarkers in theassessment of the status of environment. Specimens of hake (Merluccius merluccius L.) andsea bream (Pagellus erythrinus L.) were collected at the end of May 2005 from the locality infront of sea-port Bar (South Adriatic Sea). Parameters of oxidative stress (concentration oflipid peroxidase – LP and reduced glutathione – GSH) were determined in the liver and whitemuscle of hake and sea bream. Physical-chemical parameters (salinity, concentration ofdissolved oxygen and temperature) were determined in water of the investigated locality.Obtained results showed that the concentration of LP was higher in liver of hake and seabream in comparison to white muscle. However, significantly higher concentration of GSHwas found in white muscle of hake and sea bream in comparison to liver. These changes ofoxidative stress parameters point to tissue specificity, which is the consequence of differentmetabolic and antioxidative activity. Inter-specific differences were also established. Higherconcentrations of LP and GSH in liver of hake and in white muscle of sea bream wererecorded, due to changes of physical-chemical parameters of environment. The intensity ofoxidative stress in liver of hake and sea bream was higher in comparison to muscle.",
publisher = "Podgorica: Centre for Biodiversity of Montenegro",
journal = "The Book of Abstracts and Programme: II International Symposium of Ecologists of Montenegro ISEM2; 2006 Sep 20-24; Kotor, Montenegro",
title = "Lipid peroxidation and glutathione content in tissues of hake (Merluccius merluccius L.) and sea bream (Pagellus erythrinus L.) from the Adriatic sea",
pages = "91",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5966"
}

Ognjanović, B., Filipović, J., Nikolić, D., Marković, S., Pavlović, S., Žikić, R. V., Štajn, A. Š.,& Saičić, Z.. (2006). Lipid peroxidation and glutathione content in tissues of hake (Merluccius merluccius L.) and sea bream (Pagellus erythrinus L.) from the Adriatic sea. in The Book of Abstracts and Programme: II International Symposium of Ecologists of Montenegro ISEM2; 2006 Sep 20-24; Kotor, Montenegro
Podgorica: Centre for Biodiversity of Montenegro., 91.
https://hdl.handle.net/21.15107/rcub_ibiss_5966

Ognjanović B, Filipović J, Nikolić D, Marković S, Pavlović S, Žikić RV, Štajn AŠ, Saičić Z. Lipid peroxidation and glutathione content in tissues of hake (Merluccius merluccius L.) and sea bream (Pagellus erythrinus L.) from the Adriatic sea. in The Book of Abstracts and Programme: II International Symposium of Ecologists of Montenegro ISEM2; 2006 Sep 20-24; Kotor, Montenegro. 2006;:91.
https://hdl.handle.net/21.15107/rcub_ibiss_5966 .

Ognjanović, Branka, Filipović, Jasmina, Nikolić, Dubravka, Marković, Snežana, Pavlović, Slađan, Žikić, Radoslav V., Štajn, Andraš Š., Saičić, Zorica, "Lipid peroxidation and glutathione content in tissues of hake (Merluccius merluccius L.) and sea bream (Pagellus erythrinus L.) from the Adriatic sea" in The Book of Abstracts and Programme: II International Symposium of Ecologists of Montenegro ISEM2; 2006 Sep 20-24; Kotor, Montenegro (2006):91,
https://hdl.handle.net/21.15107/rcub_ibiss_5966 .

TY  - CONF
AU  - Ognjanović, Branka
AU  - Marković, Snežana
AU  - Pavlović, Slađan
AU  - Žikić, Radoslav V.
AU  - Štajn, Andraš Š.
AU  - Saičić, Zorica S.
PY  - 2006
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5964
AB  - Specimens of the carps (Cyprinus carpio L.) were adapted to the oxygen concentration of 6.5mg/L water (100%) as control (C) group. The first (H1) and second (H2) experimental groupswere exposed to progressive reduction of O2 to 4.2 mg/L (55%) during 115 hours and 2.3 mg/L(30%) during 230 hours, respectively. Acute hypoxia decreased glucose (H1) and pyruvate (H1and H2) concentrations in the blood of carps, while lactate level was significantly increased(H2). Concentration of red blood cells (RBCs) ATP was decreased in both (H1 and H2)groups of fish. Concomitant increase of ADP concentration was observed in (H2) group offish. The decrease of ATP/ADP ratio in (H2) group was also found. In carps of (H1) group,the activities of superoxide dismutase (SOD) and catalase (CAT) in RBCs were increasedwhereas glutathione-S-transferase (GST) activity in the plasma was increased in both groupsof fish. Glutathione peroxidase (GSH-Px) activity and the concentration of reducedglutathione (GSH) were decreased in the same conditions. Increased concentration of lipidperoxides (LP) in the blood of (H1 and H2) groups of animals in relation to the controls wasalso found. In conclusion, acute hypoxia induced a significant alteration of antioxidantenzyme activities and lipid peroxide concentration in the blood of carps (Cyprinus carpio L.)under influence of progressive reduction of oxygen concentration. All specified changes aredependent from duration of hypoxic conditions. The presented results suggest that during the evolution carps developed a well defined metabolic regulation and antioxidant defense systemfor the protection from acute hypoxia.
PB  - Podgorica: Centre for Biodiversity of Montenegro
C3  - The Book of Abstracts and Programme: II International Symposium of Ecologists of Montenegro ISEM2; 2006 Sep 20-24; Kotor, Montenegro
T1  - Alterations of energy metabolism and (anti)oxidant status in red blood cells of carps (Cyprinus carpio L.) exposed to acute hypoxia
SP  - 90
EP  - 91
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5964
ER  - 

@conference{
author = "Ognjanović, Branka and Marković, Snežana and Pavlović, Slađan and Žikić, Radoslav V. and Štajn, Andraš Š. and Saičić, Zorica S.",
year = "2006",
abstract = "Specimens of the carps (Cyprinus carpio L.) were adapted to the oxygen concentration of 6.5mg/L water (100%) as control (C) group. The first (H1) and second (H2) experimental groupswere exposed to progressive reduction of O2 to 4.2 mg/L (55%) during 115 hours and 2.3 mg/L(30%) during 230 hours, respectively. Acute hypoxia decreased glucose (H1) and pyruvate (H1and H2) concentrations in the blood of carps, while lactate level was significantly increased(H2). Concentration of red blood cells (RBCs) ATP was decreased in both (H1 and H2)groups of fish. Concomitant increase of ADP concentration was observed in (H2) group offish. The decrease of ATP/ADP ratio in (H2) group was also found. In carps of (H1) group,the activities of superoxide dismutase (SOD) and catalase (CAT) in RBCs were increasedwhereas glutathione-S-transferase (GST) activity in the plasma was increased in both groupsof fish. Glutathione peroxidase (GSH-Px) activity and the concentration of reducedglutathione (GSH) were decreased in the same conditions. Increased concentration of lipidperoxides (LP) in the blood of (H1 and H2) groups of animals in relation to the controls wasalso found. In conclusion, acute hypoxia induced a significant alteration of antioxidantenzyme activities and lipid peroxide concentration in the blood of carps (Cyprinus carpio L.)under influence of progressive reduction of oxygen concentration. All specified changes aredependent from duration of hypoxic conditions. The presented results suggest that during the evolution carps developed a well defined metabolic regulation and antioxidant defense systemfor the protection from acute hypoxia.",
publisher = "Podgorica: Centre for Biodiversity of Montenegro",
journal = "The Book of Abstracts and Programme: II International Symposium of Ecologists of Montenegro ISEM2; 2006 Sep 20-24; Kotor, Montenegro",
title = "Alterations of energy metabolism and (anti)oxidant status in red blood cells of carps (Cyprinus carpio L.) exposed to acute hypoxia",
pages = "90-91",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5964"
}

Ognjanović, B., Marković, S., Pavlović, S., Žikić, R. V., Štajn, A. Š.,& Saičić, Z. S.. (2006). Alterations of energy metabolism and (anti)oxidant status in red blood cells of carps (Cyprinus carpio L.) exposed to acute hypoxia. in The Book of Abstracts and Programme: II International Symposium of Ecologists of Montenegro ISEM2; 2006 Sep 20-24; Kotor, Montenegro
Podgorica: Centre for Biodiversity of Montenegro., 90-91.
https://hdl.handle.net/21.15107/rcub_ibiss_5964

Ognjanović B, Marković S, Pavlović S, Žikić RV, Štajn AŠ, Saičić ZS. Alterations of energy metabolism and (anti)oxidant status in red blood cells of carps (Cyprinus carpio L.) exposed to acute hypoxia. in The Book of Abstracts and Programme: II International Symposium of Ecologists of Montenegro ISEM2; 2006 Sep 20-24; Kotor, Montenegro. 2006;:90-91.
https://hdl.handle.net/21.15107/rcub_ibiss_5964 .

Ognjanović, Branka, Marković, Snežana, Pavlović, Slađan, Žikić, Radoslav V., Štajn, Andraš Š., Saičić, Zorica S., "Alterations of energy metabolism and (anti)oxidant status in red blood cells of carps (Cyprinus carpio L.) exposed to acute hypoxia" in The Book of Abstracts and Programme: II International Symposium of Ecologists of Montenegro ISEM2; 2006 Sep 20-24; Kotor, Montenegro (2006):90-91,
https://hdl.handle.net/21.15107/rcub_ibiss_5964 .

TY  - CONF
AU  - Pavlović, Slađan
AU  - Ognjanović, Branka
AU  - Štajn, Andraš
AU  - Žikić, Radoslav
AU  - Petrović, Vojislav
AU  - Saičić, Zorica
PY  - 2005
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5950
AB  - Cadmium is the important environmental pollutant and major routes of Cd intake are oral exposure and inhalation. From the total amount of food Cd intake, only about 6% is absorbed in the gastrointestinal tract of animals. The aim of our experiment was to determine the rate of Cd accumulation in liver, kidneys, skeletal muscle (musculus gastrocnemius) and testes of two months old Wistar albino male rats. Animals were divided into 2 experimental groups consisting 7 animals and treated in 30 days courses. The first group of animals functioned as controls (C) and the second group was treated with 200 mg CdCh x 5H20 in drinking water during 30 days (Cd). The average intake of 17 mg Cd/mg b.m. was calculated from the water consumed. Cadmium concentration was determined by atomic absorption spectrophotometry in the mixture of nitric and perchloric acid at the wavelength of 228.8 nm, slit 0.1 nm and lamp current 4 mA in the mixture of air and acetylene. The obtained results show a significant accumulation of Cd in all examined tissues of rats (p<0.005) in respect to controls. These results are in accordance with the findings of other authors and show that Cd mainly accumulated in the tissues of high metabolic rate, such as liver and kidneys. In these organs Cd accumulates mainly in the hepatocytes and cells of the proximal and distal renal tubules. In the cells Cd mainly deposits in the cytoplasm, nuclei and nucleoli where disturbs the cell metabolism, protein synthesis and sulfhydryl homeostasis.
PB  - Belgrade: Serbian Physiology Society
C3  - Abstract Book: The first congress of physiological sciences of Serbia and Montenegro with international participation: Molecular, Cellular and Integrative Basis of Health, Disease and Therapy; 2005 Nov 9-12; Belgrade, Serbia
T1  - Accumulation of cadmium in some tissues of rats after chronic treatment with CdCl2
SP  - 191
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5950
ER  - 

@conference{
author = "Pavlović, Slađan and Ognjanović, Branka and Štajn, Andraš and Žikić, Radoslav and Petrović, Vojislav and Saičić, Zorica",
year = "2005",
abstract = "Cadmium is the important environmental pollutant and major routes of Cd intake are oral exposure and inhalation. From the total amount of food Cd intake, only about 6% is absorbed in the gastrointestinal tract of animals. The aim of our experiment was to determine the rate of Cd accumulation in liver, kidneys, skeletal muscle (musculus gastrocnemius) and testes of two months old Wistar albino male rats. Animals were divided into 2 experimental groups consisting 7 animals and treated in 30 days courses. The first group of animals functioned as controls (C) and the second group was treated with 200 mg CdCh x 5H20 in drinking water during 30 days (Cd). The average intake of 17 mg Cd/mg b.m. was calculated from the water consumed. Cadmium concentration was determined by atomic absorption spectrophotometry in the mixture of nitric and perchloric acid at the wavelength of 228.8 nm, slit 0.1 nm and lamp current 4 mA in the mixture of air and acetylene. The obtained results show a significant accumulation of Cd in all examined tissues of rats (p<0.005) in respect to controls. These results are in accordance with the findings of other authors and show that Cd mainly accumulated in the tissues of high metabolic rate, such as liver and kidneys. In these organs Cd accumulates mainly in the hepatocytes and cells of the proximal and distal renal tubules. In the cells Cd mainly deposits in the cytoplasm, nuclei and nucleoli where disturbs the cell metabolism, protein synthesis and sulfhydryl homeostasis.",
publisher = "Belgrade: Serbian Physiology Society",
journal = "Abstract Book: The first congress of physiological sciences of Serbia and Montenegro with international participation: Molecular, Cellular and Integrative Basis of Health, Disease and Therapy; 2005 Nov 9-12; Belgrade, Serbia",
title = "Accumulation of cadmium in some tissues of rats after chronic treatment with CdCl2",
pages = "191",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5950"
}

Pavlović, S., Ognjanović, B., Štajn, A., Žikić, R., Petrović, V.,& Saičić, Z.. (2005). Accumulation of cadmium in some tissues of rats after chronic treatment with CdCl2. in Abstract Book: The first congress of physiological sciences of Serbia and Montenegro with international participation: Molecular, Cellular and Integrative Basis of Health, Disease and Therapy; 2005 Nov 9-12; Belgrade, Serbia
Belgrade: Serbian Physiology Society., 191.
https://hdl.handle.net/21.15107/rcub_ibiss_5950

Pavlović S, Ognjanović B, Štajn A, Žikić R, Petrović V, Saičić Z. Accumulation of cadmium in some tissues of rats after chronic treatment with CdCl2. in Abstract Book: The first congress of physiological sciences of Serbia and Montenegro with international participation: Molecular, Cellular and Integrative Basis of Health, Disease and Therapy; 2005 Nov 9-12; Belgrade, Serbia. 2005;:191.
https://hdl.handle.net/21.15107/rcub_ibiss_5950 .

Pavlović, Slađan, Ognjanović, Branka, Štajn, Andraš, Žikić, Radoslav, Petrović, Vojislav, Saičić, Zorica, "Accumulation of cadmium in some tissues of rats after chronic treatment with CdCl2" in Abstract Book: The first congress of physiological sciences of Serbia and Montenegro with international participation: Molecular, Cellular and Integrative Basis of Health, Disease and Therapy; 2005 Nov 9-12; Belgrade, Serbia (2005):191,
https://hdl.handle.net/21.15107/rcub_ibiss_5950 .

TY  - CONF
AU  - Ognjanović, Branka
AU  - Marković, Snežana
AU  - Pavlović, Slađan
AU  - Žikić, Radoslav V.
AU  - Štajn, Andraš Š.
AU  - Petrović, Vojislav M.
AU  - Saičić, Zorica
PY  - 2005
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5953
AB  - Cadmium (Cd) is an ubiquitous toxic metal that may induce oxidative damage by disturbing the prooxidant-antioxidant balance in the tissues. Among antioxidant micronutrients, selenium (Se) is an essential dietary trace element which ·plays an important role in a number of biological processess. The effect of cadmium on the activity of glutathione peroxidase (GSH-Px) and glutathione S-transferase (GST) which play an important role in the detoxification of xenobiotics, was studied in the liver, kidney and heart of rats. Furthermore, the role of selenium in the modulation of Cd toxicity with respect to GSH-Px and GST was also evaluated. In our experiments, cadmium exposure (15 mg Cd/kg body wt./day as CdCh for 4 weeks) to rats (n=30, male Wistar rats, age 8 weeks) resulted in decreased GSH-Px and GST activity in all organs  present  in  the  order  liver  >  kidney  >  heart.  Oral  administration  of  Se
(0.5 mg Se/kg body wt./day as Na2Se0 3 for 4 weeks) caused a significant increase in
 
IJ,,
Cl

It ra as
SC
at cc ef
ra w ar S1
Ir
 
GSH-Px activity in the order liver> heart> kidney. Selenium  administration caused	d,
an   increase   in  total  GST  activity  in  liver  but  a  decrease   in  kidney    and  heart.	Sf
Simultaneous  administration of Cd  and Se resulted  in  an  increase  GSH-Px and GST	p,
activity  in all  tissues  under study. Thus,  the mechanism  by which Se    decreases Cd	b,
toxicity in rats seems to rely on the protection of the enzyme systems   GSH-Px and	aJ GST in the three organs, possibly by forming non-toxic cadmium selenide. Selenium	th efficiently protects tissues from cadmium-induced oxidative damage
PB  - Belgrade: Serbian Physiology Society
C3  - Abstract Book: The first congress of physiological sciences of Serbia and Montenegro with international participation: Molecular, Cellular and Integrative Basis of Health, Disease and Therapy; 2005 Nov 9-12; Belgrade, Serbia
T1  - Effect of chronic cadmium exposure on glutathione peroxidase and glutathione s-transferase activities in rat: the  role  of selenium
SP  - 202
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5953
ER  - 

@conference{
author = "Ognjanović, Branka and Marković, Snežana and Pavlović, Slađan and Žikić, Radoslav V. and Štajn, Andraš Š. and Petrović, Vojislav M. and Saičić, Zorica",
year = "2005",
abstract = "Cadmium (Cd) is an ubiquitous toxic metal that may induce oxidative damage by disturbing the prooxidant-antioxidant balance in the tissues. Among antioxidant micronutrients, selenium (Se) is an essential dietary trace element which ·plays an important role in a number of biological processess. The effect of cadmium on the activity of glutathione peroxidase (GSH-Px) and glutathione S-transferase (GST) which play an important role in the detoxification of xenobiotics, was studied in the liver, kidney and heart of rats. Furthermore, the role of selenium in the modulation of Cd toxicity with respect to GSH-Px and GST was also evaluated. In our experiments, cadmium exposure (15 mg Cd/kg body wt./day as CdCh for 4 weeks) to rats (n=30, male Wistar rats, age 8 weeks) resulted in decreased GSH-Px and GST activity in all organs  present  in  the  order  liver  >  kidney  >  heart.  Oral  administration  of  Se
(0.5 mg Se/kg body wt./day as Na2Se0 3 for 4 weeks) caused a significant increase in
 
IJ,,
Cl

It ra as
SC
at cc ef
ra w ar S1
Ir
 
GSH-Px activity in the order liver> heart> kidney. Selenium  administration caused	d,
an   increase   in  total  GST  activity  in  liver  but  a  decrease   in  kidney    and  heart.	Sf
Simultaneous  administration of Cd  and Se resulted  in  an  increase  GSH-Px and GST	p,
activity  in all  tissues  under study. Thus,  the mechanism  by which Se    decreases Cd	b,
toxicity in rats seems to rely on the protection of the enzyme systems   GSH-Px and	aJ GST in the three organs, possibly by forming non-toxic cadmium selenide. Selenium	th efficiently protects tissues from cadmium-induced oxidative damage",
publisher = "Belgrade: Serbian Physiology Society",
journal = "Abstract Book: The first congress of physiological sciences of Serbia and Montenegro with international participation: Molecular, Cellular and Integrative Basis of Health, Disease and Therapy; 2005 Nov 9-12; Belgrade, Serbia",
title = "Effect of chronic cadmium exposure on glutathione peroxidase and glutathione s-transferase activities in rat: the  role  of selenium",
pages = "202",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5953"
}

Ognjanović, B., Marković, S., Pavlović, S., Žikić, R. V., Štajn, A. Š., Petrović, V. M.,& Saičić, Z.. (2005). Effect of chronic cadmium exposure on glutathione peroxidase and glutathione s-transferase activities in rat: the  role  of selenium. in Abstract Book: The first congress of physiological sciences of Serbia and Montenegro with international participation: Molecular, Cellular and Integrative Basis of Health, Disease and Therapy; 2005 Nov 9-12; Belgrade, Serbia
Belgrade: Serbian Physiology Society., 202.
https://hdl.handle.net/21.15107/rcub_ibiss_5953

Ognjanović B, Marković S, Pavlović S, Žikić RV, Štajn AŠ, Petrović VM, Saičić Z. Effect of chronic cadmium exposure on glutathione peroxidase and glutathione s-transferase activities in rat: the  role  of selenium. in Abstract Book: The first congress of physiological sciences of Serbia and Montenegro with international participation: Molecular, Cellular and Integrative Basis of Health, Disease and Therapy; 2005 Nov 9-12; Belgrade, Serbia. 2005;:202.
https://hdl.handle.net/21.15107/rcub_ibiss_5953 .

Ognjanović, Branka, Marković, Snežana, Pavlović, Slađan, Žikić, Radoslav V., Štajn, Andraš Š., Petrović, Vojislav M., Saičić, Zorica, "Effect of chronic cadmium exposure on glutathione peroxidase and glutathione s-transferase activities in rat: the  role  of selenium" in Abstract Book: The first congress of physiological sciences of Serbia and Montenegro with international participation: Molecular, Cellular and Integrative Basis of Health, Disease and Therapy; 2005 Nov 9-12; Belgrade, Serbia (2005):202,
https://hdl.handle.net/21.15107/rcub_ibiss_5953 .

TY  - CONF
AU  - Pavlović, Slađan
AU  - Ognjanović, Branka
AU  - Štajn, Andraš Š.
AU  - Žikić, Radoslav V.
AU  - Saičić, Zorica
AU  - Radojičić, Ratko
AU  - Petrović, Vojislav M.
PY  - 2003
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6020
AB  - In our study we investigated the effects of exogenous cadmium (Cd,  17 mg /day /kg  b.m.  in drinking  water), coenzyme  Q10 (CoQ 10, 16 mg/kg/dose CoQ10 dissolved in  olive  oil,  i.m.,  every  fifth  day) and Cd+CoQ10 (i n above mentioned amou nt s)  on  antioxidant  de­ fense enzyme activities (Total SOD, Mn SOD, CuZn SOD, CAT, GSH-Px, GST and  GR)  in  interscapular  hrown  adipose  tis sue (IBAT) of  male two  months  old  Wistar albin o rats during  30 days.
Cd induces significantly increased Mn SOD activity, while concomitant treatment of animals with  Cd+CoQ10  reversed  this change.   The  activity   of  CuZn   SOD   was  significantly  decreased
both in Cd and Cd+CoQ10 treated animals. CAT activity was sig­ nificantly increased in rats treated with Cd, whereas Cd+CoQ 10 normalized the activity of this enzyme. The activity of GSH-Px was significantly increased in all investigated groups of animals. Cd in­ duces an increased activity of GST,  but  by concomitant  treatment of rats with Cd+CoQ10 the GST activity was retained . The activity of GR was significantly increased in Cd treated animals, while in rats treated with Cd+CoQ10  was signi fican tl y decre_ased.
It can be concluded that Cd  induces  oxidativ  e stress  and  a l ter the activities of some antioxidant  defense  enzymes  in  IBAT of  rats. It is also shown that CoQ 10 can  normal ized  Mn  SOD,  CAT  a nd GST  activities  after  Cd-induced  changes .
PB  - Cadiz: Univerzidad de Cadiz
C3  - Book of abstracts: Oxidants and antioxidants in biology; 2003 Feb 6-9; Cadiz, Spain
T1  - Antioxidant defense enzyme activities in the interscapular brown adipose tissue of rats treated with cadmium and coenzyme Q10
SP  - 170
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_6020
ER  - 

@conference{
author = "Pavlović, Slađan and Ognjanović, Branka and Štajn, Andraš Š. and Žikić, Radoslav V. and Saičić, Zorica and Radojičić, Ratko and Petrović, Vojislav M.",
year = "2003",
abstract = "In our study we investigated the effects of exogenous cadmium (Cd,  17 mg /day /kg  b.m.  in drinking  water), coenzyme  Q10 (CoQ 10, 16 mg/kg/dose CoQ10 dissolved in  olive  oil,  i.m.,  every  fifth  day) and Cd+CoQ10 (i n above mentioned amou nt s)  on  antioxidant  de­ fense enzyme activities (Total SOD, Mn SOD, CuZn SOD, CAT, GSH-Px, GST and  GR)  in  interscapular  hrown  adipose  tis sue (IBAT) of  male two  months  old  Wistar albin o rats during  30 days.
Cd induces significantly increased Mn SOD activity, while concomitant treatment of animals with  Cd+CoQ10  reversed  this change.   The  activity   of  CuZn   SOD   was  significantly  decreased
both in Cd and Cd+CoQ10 treated animals. CAT activity was sig­ nificantly increased in rats treated with Cd, whereas Cd+CoQ 10 normalized the activity of this enzyme. The activity of GSH-Px was significantly increased in all investigated groups of animals. Cd in­ duces an increased activity of GST,  but  by concomitant  treatment of rats with Cd+CoQ10 the GST activity was retained . The activity of GR was significantly increased in Cd treated animals, while in rats treated with Cd+CoQ10  was signi fican tl y decre_ased.
It can be concluded that Cd  induces  oxidativ  e stress  and  a l ter the activities of some antioxidant  defense  enzymes  in  IBAT of  rats. It is also shown that CoQ 10 can  normal ized  Mn  SOD,  CAT  a nd GST  activities  after  Cd-induced  changes .",
publisher = "Cadiz: Univerzidad de Cadiz",
journal = "Book of abstracts: Oxidants and antioxidants in biology; 2003 Feb 6-9; Cadiz, Spain",
title = "Antioxidant defense enzyme activities in the interscapular brown adipose tissue of rats treated with cadmium and coenzyme Q10",
pages = "170",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_6020"
}

Pavlović, S., Ognjanović, B., Štajn, A. Š., Žikić, R. V., Saičić, Z., Radojičić, R.,& Petrović, V. M.. (2003). Antioxidant defense enzyme activities in the interscapular brown adipose tissue of rats treated with cadmium and coenzyme Q10. in Book of abstracts: Oxidants and antioxidants in biology; 2003 Feb 6-9; Cadiz, Spain
Cadiz: Univerzidad de Cadiz., 170.
https://hdl.handle.net/21.15107/rcub_ibiss_6020

Pavlović S, Ognjanović B, Štajn AŠ, Žikić RV, Saičić Z, Radojičić R, Petrović VM. Antioxidant defense enzyme activities in the interscapular brown adipose tissue of rats treated with cadmium and coenzyme Q10. in Book of abstracts: Oxidants and antioxidants in biology; 2003 Feb 6-9; Cadiz, Spain. 2003;:170.
https://hdl.handle.net/21.15107/rcub_ibiss_6020 .

Pavlović, Slađan, Ognjanović, Branka, Štajn, Andraš Š., Žikić, Radoslav V., Saičić, Zorica, Radojičić, Ratko, Petrović, Vojislav M., "Antioxidant defense enzyme activities in the interscapular brown adipose tissue of rats treated with cadmium and coenzyme Q10" in Book of abstracts: Oxidants and antioxidants in biology; 2003 Feb 6-9; Cadiz, Spain (2003):170,
https://hdl.handle.net/21.15107/rcub_ibiss_6020 .

TY  - CONF
AU  - Ognjanović, Branka
AU  - Pavlović, Slađan
AU  - Maletić, Snežana
AU  - Žikić, Radoslav V.
AU  - Štajn, Andraš Š.
AU  - Saičić, Zorica
PY  - 2003
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5963
AB  - Cadmium (Cd) is an ubiquitous toxic metal that is involved in a variety of pathological condicions. The present study investigated the po-,sible protective role of vitamin E (Vit E) in cadmium induced oxidative stress in the blood of rats. Male, Wistar albino rats 3 months old (weighing 280 ± 30 g) were used in our experiments. Rats were injected with a single dose (1) of CdClz (0,4 mg Cd/kg b.m., i.p., 24h before the sacrificing), (2)Vit E + Cd (20 UI Vit E/kg b.m., i.m., 48h +0,4 mg Cd/kg b.m., i.p., 24h before the sacrificing). The group of animals without treatment was control. The activities of enzymatic components of AOS: copper zinc containing superoxide-dismutase (CuZn SOD), catalase (CAT), glutathione-peroxidase   (GSH­
Px), glutathione-reductase (GR) and glutathione-S-transferase (GST) were  analyzed
in erythrocytes  and concentrations of non-enzymatic  components of  AOS: reduced	'
glutathione   (GSH),  ascorbic  acid  (AsA)  and  vitamin   E  (Vit  E),  as  well  as  lipid    peroxide  (LP) concentration  were determined  in the blood of rats.  Acute intoxication	I of rats with  Cd  were followed  by significantly  increased  LP  and increased activities		I
of enzymatic, as well as concentrations of non-enzymatic components of AOS in blood. The pretreatment with vitamin E after acute intoxication of rats with Cd partialy improved components of AOS. Our results indicate that liposoluble antioxidant (Vit E) resulted as suitable and potent antioxidant action, probably as consequence of quenchening of reactive oxygen species, inhibiton of lipid peroxidation and prevention of free-radical mediated injuries. The results of this study suggested that vitamin E functions as antioxygenic nutrients.
PB  - Belgrade: Serbian Physiology Society
C3  - Abstract Book: Conference of Physiological Sciences with international participation: Risk Factors and Health: from Molecule to the Scientific Basis of Prevention; 2003 Nov 7-9; Belgrade, Zrenjanin, Serbia
T1  - Effects of acute Cd-treatment on antioxidant defense system in the blood of rats: protective role of vitamin E
SP  - 69
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5963
ER  - 

@conference{
author = "Ognjanović, Branka and Pavlović, Slađan and Maletić, Snežana and Žikić, Radoslav V. and Štajn, Andraš Š. and Saičić, Zorica",
year = "2003",
abstract = "Cadmium (Cd) is an ubiquitous toxic metal that is involved in a variety of pathological condicions. The present study investigated the po-,sible protective role of vitamin E (Vit E) in cadmium induced oxidative stress in the blood of rats. Male, Wistar albino rats 3 months old (weighing 280 ± 30 g) were used in our experiments. Rats were injected with a single dose (1) of CdClz (0,4 mg Cd/kg b.m., i.p., 24h before the sacrificing), (2)Vit E + Cd (20 UI Vit E/kg b.m., i.m., 48h +0,4 mg Cd/kg b.m., i.p., 24h before the sacrificing). The group of animals without treatment was control. The activities of enzymatic components of AOS: copper zinc containing superoxide-dismutase (CuZn SOD), catalase (CAT), glutathione-peroxidase   (GSH­
Px), glutathione-reductase (GR) and glutathione-S-transferase (GST) were  analyzed
in erythrocytes  and concentrations of non-enzymatic  components of  AOS: reduced	'
glutathione   (GSH),  ascorbic  acid  (AsA)  and  vitamin   E  (Vit  E),  as  well  as  lipid    peroxide  (LP) concentration  were determined  in the blood of rats.  Acute intoxication	I of rats with  Cd  were followed  by significantly  increased  LP  and increased activities		I
of enzymatic, as well as concentrations of non-enzymatic components of AOS in blood. The pretreatment with vitamin E after acute intoxication of rats with Cd partialy improved components of AOS. Our results indicate that liposoluble antioxidant (Vit E) resulted as suitable and potent antioxidant action, probably as consequence of quenchening of reactive oxygen species, inhibiton of lipid peroxidation and prevention of free-radical mediated injuries. The results of this study suggested that vitamin E functions as antioxygenic nutrients.",
publisher = "Belgrade: Serbian Physiology Society",
journal = "Abstract Book: Conference of Physiological Sciences with international participation: Risk Factors and Health: from Molecule to the Scientific Basis of Prevention; 2003 Nov 7-9; Belgrade, Zrenjanin, Serbia",
title = "Effects of acute Cd-treatment on antioxidant defense system in the blood of rats: protective role of vitamin E",
pages = "69",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5963"
}

Ognjanović, B., Pavlović, S., Maletić, S., Žikić, R. V., Štajn, A. Š.,& Saičić, Z.. (2003). Effects of acute Cd-treatment on antioxidant defense system in the blood of rats: protective role of vitamin E. in Abstract Book: Conference of Physiological Sciences with international participation: Risk Factors and Health: from Molecule to the Scientific Basis of Prevention; 2003 Nov 7-9; Belgrade, Zrenjanin, Serbia
Belgrade: Serbian Physiology Society., 69.
https://hdl.handle.net/21.15107/rcub_ibiss_5963

Ognjanović B, Pavlović S, Maletić S, Žikić RV, Štajn AŠ, Saičić Z. Effects of acute Cd-treatment on antioxidant defense system in the blood of rats: protective role of vitamin E. in Abstract Book: Conference of Physiological Sciences with international participation: Risk Factors and Health: from Molecule to the Scientific Basis of Prevention; 2003 Nov 7-9; Belgrade, Zrenjanin, Serbia. 2003;:69.
https://hdl.handle.net/21.15107/rcub_ibiss_5963 .

Ognjanović, Branka, Pavlović, Slađan, Maletić, Snežana, Žikić, Radoslav V., Štajn, Andraš Š., Saičić, Zorica, "Effects of acute Cd-treatment on antioxidant defense system in the blood of rats: protective role of vitamin E" in Abstract Book: Conference of Physiological Sciences with international participation: Risk Factors and Health: from Molecule to the Scientific Basis of Prevention; 2003 Nov 7-9; Belgrade, Zrenjanin, Serbia (2003):69,
https://hdl.handle.net/21.15107/rcub_ibiss_5963 .

TY  - CONF
AU  - Ognjanović, Branka
AU  - Pavlović, Slađan
AU  - Maletić, Snežana
AU  - Žikić, Radoslav V.
AU  - Štajn, Andraš Š.
AU  - Saičić, Zorica
PY  - 2003
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5962
AB  - Cadmium (Cd) is a widely used industrial chemical and it is well known that Cd induces  on  oxidative  stress  that  in  oxidative  deterioration  of  biological macromolec ules. Coenzyme Q10 (CoQ10) is a lipid co-factor th at is involved in numerous enzymatic processes and is present in most cellular membranes.  Thus, CoQ1o is also important as a lipophilic regulator of oxidative stress.
The aim of this study was to investigate a possible protective influence of CoQ 10  in Cd induced oxidative stress in the rat hearts.
Male, Wistar albino rats (3 months old), injected with (I) CdCh (0.4  mg  Cd/k b.m.,i.p., 24h before the sacrificing), (2) CoQ10 + Cd (20 mg CoQ10/kg b.m., i.m., 48 before the sacrificing + 0.4 mg Cd/kg b.m., i.p., 24h before the sacrificing) and (3) CoQ10 (20 mg CoQ10/kg b.m., i.m., 48h before the sacri ficing). Acute intoxication· of rats with Cd were  followed  by significantly  increased  of  all examined    antioxidant
defense enzymes (total SOD, Mn SOD, CnZn SOD, CAT, GSH-Px, GST and GR), while AsA and Vit E concentrations were significantly decreased. A significantly increased accumulation of Cd in heart tissue was observed· in animals treated with Cd.  These  ubiquitous  reaction·s of  Cd  result  as  its  toxic  effects  on  whole  heart  and other tissues and organs.
The protective role of CoQ1o in acute Cd intoxication results as decreased  activities  of total SOD, CuZn SOD, GSH-Px and GST. AsA concentration was also reversed to the control value. However, pretreatment with CoQ10 induced  further  increase  of CAT and GR activities and Vit E concentration. Our results showed that CoQ10 functions as a lipid-soluble antioxidant, and protects cells from  lipid  peroxidation.  The results of our study suggested that CoQ 10 functions as a potent antioxidant in protection of rat heart against oxidative stress induced by  Cd.
PB  - Belgrade: Serbian Physiology Society
C3  - Abstract Book: Conference  of Physiological  Sciences with international  participation: Risk Factors and Health: from Molecule to the Scientific Basis of Prevention; 2003 Nov 7-9; Belgrade, Zrenjanin, Serbia
T1  - Prevention of cadmium-induced effects on antioxidant defense system of rat heart by coenzyme  Q10
SP  - 68
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5962
ER  - 

@conference{
author = "Ognjanović, Branka and Pavlović, Slađan and Maletić, Snežana and Žikić, Radoslav V. and Štajn, Andraš Š. and Saičić, Zorica",
year = "2003",
abstract = "Cadmium (Cd) is a widely used industrial chemical and it is well known that Cd induces  on  oxidative  stress  that  in  oxidative  deterioration  of  biological macromolec ules. Coenzyme Q10 (CoQ10) is a lipid co-factor th at is involved in numerous enzymatic processes and is present in most cellular membranes.  Thus, CoQ1o is also important as a lipophilic regulator of oxidative stress.
The aim of this study was to investigate a possible protective influence of CoQ 10  in Cd induced oxidative stress in the rat hearts.
Male, Wistar albino rats (3 months old), injected with (I) CdCh (0.4  mg  Cd/k b.m.,i.p., 24h before the sacrificing), (2) CoQ10 + Cd (20 mg CoQ10/kg b.m., i.m., 48 before the sacrificing + 0.4 mg Cd/kg b.m., i.p., 24h before the sacrificing) and (3) CoQ10 (20 mg CoQ10/kg b.m., i.m., 48h before the sacri ficing). Acute intoxication· of rats with Cd were  followed  by significantly  increased  of  all examined    antioxidant
defense enzymes (total SOD, Mn SOD, CnZn SOD, CAT, GSH-Px, GST and GR), while AsA and Vit E concentrations were significantly decreased. A significantly increased accumulation of Cd in heart tissue was observed· in animals treated with Cd.  These  ubiquitous  reaction·s of  Cd  result  as  its  toxic  effects  on  whole  heart  and other tissues and organs.
The protective role of CoQ1o in acute Cd intoxication results as decreased  activities  of total SOD, CuZn SOD, GSH-Px and GST. AsA concentration was also reversed to the control value. However, pretreatment with CoQ10 induced  further  increase  of CAT and GR activities and Vit E concentration. Our results showed that CoQ10 functions as a lipid-soluble antioxidant, and protects cells from  lipid  peroxidation.  The results of our study suggested that CoQ 10 functions as a potent antioxidant in protection of rat heart against oxidative stress induced by  Cd.",
publisher = "Belgrade: Serbian Physiology Society",
journal = "Abstract Book: Conference  of Physiological  Sciences with international  participation: Risk Factors and Health: from Molecule to the Scientific Basis of Prevention; 2003 Nov 7-9; Belgrade, Zrenjanin, Serbia",
title = "Prevention of cadmium-induced effects on antioxidant defense system of rat heart by coenzyme  Q10",
pages = "68",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5962"
}

Ognjanović, B., Pavlović, S., Maletić, S., Žikić, R. V., Štajn, A. Š.,& Saičić, Z.. (2003). Prevention of cadmium-induced effects on antioxidant defense system of rat heart by coenzyme  Q10. in Abstract Book: Conference  of Physiological  Sciences with international  participation: Risk Factors and Health: from Molecule to the Scientific Basis of Prevention; 2003 Nov 7-9; Belgrade, Zrenjanin, Serbia
Belgrade: Serbian Physiology Society., 68.
https://hdl.handle.net/21.15107/rcub_ibiss_5962

Ognjanović B, Pavlović S, Maletić S, Žikić RV, Štajn AŠ, Saičić Z. Prevention of cadmium-induced effects on antioxidant defense system of rat heart by coenzyme  Q10. in Abstract Book: Conference  of Physiological  Sciences with international  participation: Risk Factors and Health: from Molecule to the Scientific Basis of Prevention; 2003 Nov 7-9; Belgrade, Zrenjanin, Serbia. 2003;:68.
https://hdl.handle.net/21.15107/rcub_ibiss_5962 .

Ognjanović, Branka, Pavlović, Slađan, Maletić, Snežana, Žikić, Radoslav V., Štajn, Andraš Š., Saičić, Zorica, "Prevention of cadmium-induced effects on antioxidant defense system of rat heart by coenzyme  Q10" in Abstract Book: Conference  of Physiological  Sciences with international  participation: Risk Factors and Health: from Molecule to the Scientific Basis of Prevention; 2003 Nov 7-9; Belgrade, Zrenjanin, Serbia (2003):68,
https://hdl.handle.net/21.15107/rcub_ibiss_5962 .

TY  - CONF
AU  - Pavlović, Slađan
AU  - Ognjanović, Branka
AU  - Štajn, Andraš Š.
AU  - Žikić, Radoslav V.
AU  - Saičić, Zorica
AU  - Radojičić, Ratko
AU  - Petrović, Vojislav M.
PY  - 2002
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6118
AB  - In our experiments male two months old Wistar albino rats were used. In the experim with acute Cd intoxication animals were injected with  (1)  Cd  (0.4  mg  CdCh/kg  b.m.,  i.p., before the sacrificing), (2) Vitamin E+Coenzyme  Q10+Cd (20  IU Vit E/kg  b.m .,  i.m. , 48h be the  sacrificing+  20  mg  CoQ10/kg  b.m.,  i.m.,  48h before  the sacrificing+  0.4  mg  CdCb/kg b i p., 24h before the sacrificing). Third group (3) was control  (C).  In  the experiment  with chro Cd intoxication the animals were treated as follov,s: (1) Cd (14 mg/day/kg b.m. CdCb in drink water during 15 days (Cd), (2) Vit E+CoQ 1o+Cd (pretreated with 20 IU/kg/dose of Vit E and mg/kg/dose  of  CoQ10  i.m., every  fifth day during  15 days  and  then  treated  with  14   mg/day b.m. of Cd during next 15 days Third group (3) was control (C). After the treatment the rats w sacrificed by decapitation and blood samples were collected and analyzed. In the blood of rats conce ntration of lipide peroxides (LP) were evaluated, while the activity  of  gluta tione transferase was assayed in the plasma after separation from the    blood cells.
The results obtained in our experiments show that acute treatment with Cd leads to significantly increased LP concentration (p<0.01) in the blood of rats in respect to the con animals. Pretreatment  with  Vit  E+CoQ 10  pryor  to  Cd exposure  normalyzed  the concentration LP   in   the· blood.   Contrary   to   that,   in   chronic   Cd   intoxication   concentration   of LP significantly   decreased   (p<0.005)   in   comparison   to   the   control   value.   Pretreatment   Vit E+CoQ 10 pryor to Cd intoxication influences an additional decrease of LP concentra (p<0.005) compared with controls. It appears that in chronic Cd treatment the period of 15 day sufficient for the development of efficient red blood cell protection against Cd (per)oxida  damage. The activity of GST in the plasma of rats acutely treated with Cd was  signi fica  increased in respect to the controls (p<0.02). Pretreatment of rats with Vit E+CoQ 10 influenc significant decrease of GST activity in the plasma (p<0.05).  Similar  results  were  obtained chronic Cd intoxication where Cd induces a significantly higher activity of GST in the pla (p<0.01), while pretreatment  with Vit E+CoQ 10 reversed this value to the control   level.
From  the   presented   results,  it  can  be  concluded   that  Cd   both   in  acute  and  chr
intoxication influences blood LP concentration and plasma GST activi ty . Pretreatment antioxidants, such as Vit E and CoQ 10 diminishes the toxi c effects of Cd on both evalu parameters. At the same time, we were also noticed a different mechanisms of defence against toxicity in acute and in chronic intoxication, especially in the case of blood LP con cen tration.
PB  - Morgantown: National Institute for Occupational Safety and Health
C3  - 2nd Conference on Molecular Mechanisms of Metal Toxicity; 2002 Sep 8-11; Morgantown, USA
T1  - Protective role of vitamin E and coenzyme Q10 on blood LP concentration and GST activity in rats after acute and chronic cadmium intoxication
SP  - P11
EP  - P11
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_6118
ER  - 

@conference{
author = "Pavlović, Slađan and Ognjanović, Branka and Štajn, Andraš Š. and Žikić, Radoslav V. and Saičić, Zorica and Radojičić, Ratko and Petrović, Vojislav M.",
year = "2002",
abstract = "In our experiments male two months old Wistar albino rats were used. In the experim with acute Cd intoxication animals were injected with  (1)  Cd  (0.4  mg  CdCh/kg  b.m.,  i.p., before the sacrificing), (2) Vitamin E+Coenzyme  Q10+Cd (20  IU Vit E/kg  b.m .,  i.m. , 48h be the  sacrificing+  20  mg  CoQ10/kg  b.m.,  i.m.,  48h before  the sacrificing+  0.4  mg  CdCb/kg b i p., 24h before the sacrificing). Third group (3) was control  (C).  In  the experiment  with chro Cd intoxication the animals were treated as follov,s: (1) Cd (14 mg/day/kg b.m. CdCb in drink water during 15 days (Cd), (2) Vit E+CoQ 1o+Cd (pretreated with 20 IU/kg/dose of Vit E and mg/kg/dose  of  CoQ10  i.m., every  fifth day during  15 days  and  then  treated  with  14   mg/day b.m. of Cd during next 15 days Third group (3) was control (C). After the treatment the rats w sacrificed by decapitation and blood samples were collected and analyzed. In the blood of rats conce ntration of lipide peroxides (LP) were evaluated, while the activity  of  gluta tione transferase was assayed in the plasma after separation from the    blood cells.
The results obtained in our experiments show that acute treatment with Cd leads to significantly increased LP concentration (p<0.01) in the blood of rats in respect to the con animals. Pretreatment  with  Vit  E+CoQ 10  pryor  to  Cd exposure  normalyzed  the concentration LP   in   the· blood.   Contrary   to   that,   in   chronic   Cd   intoxication   concentration   of LP significantly   decreased   (p<0.005)   in   comparison   to   the   control   value.   Pretreatment   Vit E+CoQ 10 pryor to Cd intoxication influences an additional decrease of LP concentra (p<0.005) compared with controls. It appears that in chronic Cd treatment the period of 15 day sufficient for the development of efficient red blood cell protection against Cd (per)oxida  damage. The activity of GST in the plasma of rats acutely treated with Cd was  signi fica  increased in respect to the controls (p<0.02). Pretreatment of rats with Vit E+CoQ 10 influenc significant decrease of GST activity in the plasma (p<0.05).  Similar  results  were  obtained chronic Cd intoxication where Cd induces a significantly higher activity of GST in the pla (p<0.01), while pretreatment  with Vit E+CoQ 10 reversed this value to the control   level.
From  the   presented   results,  it  can  be  concluded   that  Cd   both   in  acute  and  chr
intoxication influences blood LP concentration and plasma GST activi ty . Pretreatment antioxidants, such as Vit E and CoQ 10 diminishes the toxi c effects of Cd on both evalu parameters. At the same time, we were also noticed a different mechanisms of defence against toxicity in acute and in chronic intoxication, especially in the case of blood LP con cen tration.",
publisher = "Morgantown: National Institute for Occupational Safety and Health",
journal = "2nd Conference on Molecular Mechanisms of Metal Toxicity; 2002 Sep 8-11; Morgantown, USA",
title = "Protective role of vitamin E and coenzyme Q10 on blood LP concentration and GST activity in rats after acute and chronic cadmium intoxication",
pages = "P11-P11",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_6118"
}

Pavlović, S., Ognjanović, B., Štajn, A. Š., Žikić, R. V., Saičić, Z., Radojičić, R.,& Petrović, V. M.. (2002). Protective role of vitamin E and coenzyme Q10 on blood LP concentration and GST activity in rats after acute and chronic cadmium intoxication. in 2nd Conference on Molecular Mechanisms of Metal Toxicity; 2002 Sep 8-11; Morgantown, USA
Morgantown: National Institute for Occupational Safety and Health., P11-P11.
https://hdl.handle.net/21.15107/rcub_ibiss_6118

Pavlović S, Ognjanović B, Štajn AŠ, Žikić RV, Saičić Z, Radojičić R, Petrović VM. Protective role of vitamin E and coenzyme Q10 on blood LP concentration and GST activity in rats after acute and chronic cadmium intoxication. in 2nd Conference on Molecular Mechanisms of Metal Toxicity; 2002 Sep 8-11; Morgantown, USA. 2002;:P11-P11.
https://hdl.handle.net/21.15107/rcub_ibiss_6118 .

Pavlović, Slađan, Ognjanović, Branka, Štajn, Andraš Š., Žikić, Radoslav V., Saičić, Zorica, Radojičić, Ratko, Petrović, Vojislav M., "Protective role of vitamin E and coenzyme Q10 on blood LP concentration and GST activity in rats after acute and chronic cadmium intoxication" in 2nd Conference on Molecular Mechanisms of Metal Toxicity; 2002 Sep 8-11; Morgantown, USA (2002):P11-P11,
https://hdl.handle.net/21.15107/rcub_ibiss_6118 .

TY  - CONF
AU  - Ognjanović, Branka
AU  - Pavlović, Slađan
AU  - Maletić, Snežana
AU  - Žikić, Radoslav V.
AU  - Štajn, Andraš Š.
AU  - Saičić, Zorica
PY  - 2002
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5959
AB  - Cadmium induced lipid peroxidation (LPO) and altering the antioxidant system after the administration  of a sin­ gle dose of CdCl2 (0.4 mg /kg body wt, i.p., 24 hours before the sacrificing) was studied in the blood of rats.  The protect ive role of coenzyme Q (20 mg  CoQ10/kg body wt, i.m., 48 hours before the sacrificing) and vita­ min E (20 iu Vit E/kg body wt, i. m., 48 hours before the sacrificing) was also studied in  the  blood  of  rats after the acute intoxication with cadmium.  The  treatment with Cd increased LPO in the blood while animals pre­ treated with coenzyme Q and/or vitamin E prior to Cd treatment showed decreased LPO as compared with animals  given  Cd  alone.  Activities  of  superoxide dismu­tase   (SOD),   catalase   (CATt,  glutathion  e peroxidase (GS H-Px) and  glut athione  reductas e  (GR)  in  erythro­cytes  and  activities  glutathione  S-transferase   (GST)   as well   as  concentrations  ascorbic   acid  (AsA)  and   vitamin E (Vit E) in the plasma were significantly incr eased of Cd  and  CoQ 10   treated  rats  (p<0.05  or  Jess).  The  pre­ treatment  with  coen zyme  Q  and/or  vitamin   E  prior  to  Cd administration partially reversed such  changes.  In animals  treatment  with  antioxidants prior  to   Cd   treat­ment  decreased  significantly   activiti es   of   SOD,   CAT and GR in erythrocytes, and activity GST and concen­trations AsA in the plasma  and  were  the  same  as  con­  trols  values.  However, the  pretreatment with  coenzyme Q and/or vitamin E prior to Cd administration showed increased  erythrocyte  GSH-Px  activity  and  concentra­tions vit amin E in the plasma as compared  with  animals given Cd alone. The results sugges that Cd int oxic ation induces oxidative stress and  alters  the  antioxidant sys­tem, resulting  in  increased  lipid  peroxidation  to  rat erythrocytes. Coenzyme Q and vitamin  E are the  power­ful liposoluble antioxidants which in cells quenched free oxygen radicals, inhibit lipid peroxidation and  thus  pre­vent free-radical mediated oxidant  injuries.  It  is  known that coenzyme Q and vitamin E may act sinergically as antioxidanrs. The pretreatment with coenzyme Q and /or vitamin E prior to Cd treatment showed protective effect against  toxic  influence  of  Cd  on  peroxidation  of  mem­ brane lipids and  altering  the  antioxidant  system  in  the blood  of rats.
PB  - Priština: Academy of Sciences and Arts of SAP Kosovo. Division of Natural Sciences: Society for Biology and Experimental Medicine SAP Kosovo
C3  - Conference of the Serbian Physiological Society; 2001 Dec 20-23; Zlatibor, Serbia
T1  - Effects of Coenzyme Q10 and Vitamin E on antioxidant defense system in the blood of rats acutely exposed to cadmium
SP  - 70
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5959
ER  - 

@conference{
author = "Ognjanović, Branka and Pavlović, Slađan and Maletić, Snežana and Žikić, Radoslav V. and Štajn, Andraš Š. and Saičić, Zorica",
year = "2002",
abstract = "Cadmium induced lipid peroxidation (LPO) and altering the antioxidant system after the administration  of a sin­ gle dose of CdCl2 (0.4 mg /kg body wt, i.p., 24 hours before the sacrificing) was studied in the blood of rats.  The protect ive role of coenzyme Q (20 mg  CoQ10/kg body wt, i.m., 48 hours before the sacrificing) and vita­ min E (20 iu Vit E/kg body wt, i. m., 48 hours before the sacrificing) was also studied in  the  blood  of  rats after the acute intoxication with cadmium.  The  treatment with Cd increased LPO in the blood while animals pre­ treated with coenzyme Q and/or vitamin E prior to Cd treatment showed decreased LPO as compared with animals  given  Cd  alone.  Activities  of  superoxide dismu­tase   (SOD),   catalase   (CATt,  glutathion  e peroxidase (GS H-Px) and  glut athione  reductas e  (GR)  in  erythro­cytes  and  activities  glutathione  S-transferase   (GST)   as well   as  concentrations  ascorbic   acid  (AsA)  and   vitamin E (Vit E) in the plasma were significantly incr eased of Cd  and  CoQ 10   treated  rats  (p<0.05  or  Jess).  The  pre­ treatment  with  coen zyme  Q  and/or  vitamin   E  prior  to  Cd administration partially reversed such  changes.  In animals  treatment  with  antioxidants prior  to   Cd   treat­ment  decreased  significantly   activiti es   of   SOD,   CAT and GR in erythrocytes, and activity GST and concen­trations AsA in the plasma  and  were  the  same  as  con­  trols  values.  However, the  pretreatment with  coenzyme Q and/or vitamin E prior to Cd administration showed increased  erythrocyte  GSH-Px  activity  and  concentra­tions vit amin E in the plasma as compared  with  animals given Cd alone. The results sugges that Cd int oxic ation induces oxidative stress and  alters  the  antioxidant sys­tem, resulting  in  increased  lipid  peroxidation  to  rat erythrocytes. Coenzyme Q and vitamin  E are the  power­ful liposoluble antioxidants which in cells quenched free oxygen radicals, inhibit lipid peroxidation and  thus  pre­vent free-radical mediated oxidant  injuries.  It  is  known that coenzyme Q and vitamin E may act sinergically as antioxidanrs. The pretreatment with coenzyme Q and /or vitamin E prior to Cd treatment showed protective effect against  toxic  influence  of  Cd  on  peroxidation  of  mem­ brane lipids and  altering  the  antioxidant  system  in  the blood  of rats.",
publisher = "Priština: Academy of Sciences and Arts of SAP Kosovo. Division of Natural Sciences: Society for Biology and Experimental Medicine SAP Kosovo",
journal = "Conference of the Serbian Physiological Society; 2001 Dec 20-23; Zlatibor, Serbia",
title = "Effects of Coenzyme Q10 and Vitamin E on antioxidant defense system in the blood of rats acutely exposed to cadmium",
pages = "70",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5959"
}

Ognjanović, B., Pavlović, S., Maletić, S., Žikić, R. V., Štajn, A. Š.,& Saičić, Z.. (2002). Effects of Coenzyme Q10 and Vitamin E on antioxidant defense system in the blood of rats acutely exposed to cadmium. in Conference of the Serbian Physiological Society; 2001 Dec 20-23; Zlatibor, Serbia
Priština: Academy of Sciences and Arts of SAP Kosovo. Division of Natural Sciences: Society for Biology and Experimental Medicine SAP Kosovo., 70.
https://hdl.handle.net/21.15107/rcub_ibiss_5959

Ognjanović B, Pavlović S, Maletić S, Žikić RV, Štajn AŠ, Saičić Z. Effects of Coenzyme Q10 and Vitamin E on antioxidant defense system in the blood of rats acutely exposed to cadmium. in Conference of the Serbian Physiological Society; 2001 Dec 20-23; Zlatibor, Serbia. 2002;:70.
https://hdl.handle.net/21.15107/rcub_ibiss_5959 .

Ognjanović, Branka, Pavlović, Slađan, Maletić, Snežana, Žikić, Radoslav V., Štajn, Andraš Š., Saičić, Zorica, "Effects of Coenzyme Q10 and Vitamin E on antioxidant defense system in the blood of rats acutely exposed to cadmium" in Conference of the Serbian Physiological Society; 2001 Dec 20-23; Zlatibor, Serbia (2002):70,
https://hdl.handle.net/21.15107/rcub_ibiss_5959 .

TY  - CONF
AU  - Marković, Mirjana
AU  - Žikić, Radoslav V.
AU  - Štajn, Andraš Š.
AU  - Ognjanović, Branka
AU  - Saičić, Zorica
AU  - Pavlović, Slađan
AU  - Radojičić, Ratko
PY  - 2002
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5961
AB  - In our experiments conunon carps (Cyprinus carpio   L.) were    acclimated    to    an    oxygen    concentration  of 7.3 lmg/L water (100%) - control (C) group. Two ex­ perimental groups (H1, H2) were exposed to acute hy­ poxia. One of them was exposed to a progressive reduc­tion of 02 to 4.1 O2 mg/L (55%) for 1 ¼ hour s and another 1.95mg/L (25%) for 2 hours, respectively. The fourth experimental group (HP) was exposed to a progressive increase of oxygen concentration O2 to 10 mg/L (150%) for I5 minutes, respectively. In our exper iment was determinated antioxidant defense· s yste m enzymes activity (superoxide-dismutase   (SOD),   catalase   (CAT) glutathione-peroxidase (GSH-Px) , and glutathione-reductase (GR) and glutathione-S-transferase (GST) ac­ tivity (Misra, H.P. and Fridovich, I. (19 72), Beutler (1982), Tamure et al. ( I982), Habig et  al.  (1974), Glatzle et  al. (1974).
Our  res ult s  show  that  stress  caused  by  acute  hypoxia and hyperoxia significantly changes the activities of antioxidant defense system enzymes, superoxide-dis­mutase   (SOD),  glutathione-peroxidase   (GSH-Px),   and glutathione-reductase (GR) in carps gills. Acute pro­ longed hypoxia (H2) caused a cetrain  degree  of  adapta­tion in respect  to  catalase  (CAT)  and  glutathione-S­ transferase  (GST) activity .
PB  - Priština: Academy of Sciences and Arts of SAP Kosovo. Division of Natural Sciences: Society for Biology and Experimental Medicine SAP Kosovo
C3  - Conference of the Serbian Physiological Society; 2001 Dec 20-23; Zlatibor, Serbia
T1  - Effects of acute hypoxia and hyperoxia on antioxidant defense system in gills of carps (Cyprinus carpio L.)
SP  - 71
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5961
ER  - 

@conference{
author = "Marković, Mirjana and Žikić, Radoslav V. and Štajn, Andraš Š. and Ognjanović, Branka and Saičić, Zorica and Pavlović, Slađan and Radojičić, Ratko",
year = "2002",
abstract = "In our experiments conunon carps (Cyprinus carpio   L.) were    acclimated    to    an    oxygen    concentration  of 7.3 lmg/L water (100%) - control (C) group. Two ex­ perimental groups (H1, H2) were exposed to acute hy­ poxia. One of them was exposed to a progressive reduc­tion of 02 to 4.1 O2 mg/L (55%) for 1 ¼ hour s and another 1.95mg/L (25%) for 2 hours, respectively. The fourth experimental group (HP) was exposed to a progressive increase of oxygen concentration O2 to 10 mg/L (150%) for I5 minutes, respectively. In our exper iment was determinated antioxidant defense· s yste m enzymes activity (superoxide-dismutase   (SOD),   catalase   (CAT) glutathione-peroxidase (GSH-Px) , and glutathione-reductase (GR) and glutathione-S-transferase (GST) ac­ tivity (Misra, H.P. and Fridovich, I. (19 72), Beutler (1982), Tamure et al. ( I982), Habig et  al.  (1974), Glatzle et  al. (1974).
Our  res ult s  show  that  stress  caused  by  acute  hypoxia and hyperoxia significantly changes the activities of antioxidant defense system enzymes, superoxide-dis­mutase   (SOD),  glutathione-peroxidase   (GSH-Px),   and glutathione-reductase (GR) in carps gills. Acute pro­ longed hypoxia (H2) caused a cetrain  degree  of  adapta­tion in respect  to  catalase  (CAT)  and  glutathione-S­ transferase  (GST) activity .",
publisher = "Priština: Academy of Sciences and Arts of SAP Kosovo. Division of Natural Sciences: Society for Biology and Experimental Medicine SAP Kosovo",
journal = "Conference of the Serbian Physiological Society; 2001 Dec 20-23; Zlatibor, Serbia",
title = "Effects of acute hypoxia and hyperoxia on antioxidant defense system in gills of carps (Cyprinus carpio L.)",
pages = "71",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5961"
}

Marković, M., Žikić, R. V., Štajn, A. Š., Ognjanović, B., Saičić, Z., Pavlović, S.,& Radojičić, R.. (2002). Effects of acute hypoxia and hyperoxia on antioxidant defense system in gills of carps (Cyprinus carpio L.). in Conference of the Serbian Physiological Society; 2001 Dec 20-23; Zlatibor, Serbia
Priština: Academy of Sciences and Arts of SAP Kosovo. Division of Natural Sciences: Society for Biology and Experimental Medicine SAP Kosovo., 71.
https://hdl.handle.net/21.15107/rcub_ibiss_5961

Marković M, Žikić RV, Štajn AŠ, Ognjanović B, Saičić Z, Pavlović S, Radojičić R. Effects of acute hypoxia and hyperoxia on antioxidant defense system in gills of carps (Cyprinus carpio L.). in Conference of the Serbian Physiological Society; 2001 Dec 20-23; Zlatibor, Serbia. 2002;:71.
https://hdl.handle.net/21.15107/rcub_ibiss_5961 .

Marković, Mirjana, Žikić, Radoslav V., Štajn, Andraš Š., Ognjanović, Branka, Saičić, Zorica, Pavlović, Slađan, Radojičić, Ratko, "Effects of acute hypoxia and hyperoxia on antioxidant defense system in gills of carps (Cyprinus carpio L.)" in Conference of the Serbian Physiological Society; 2001 Dec 20-23; Zlatibor, Serbia (2002):71,
https://hdl.handle.net/21.15107/rcub_ibiss_5961 .

TY  - CONF
AU  - Ognjanović, Branka
AU  - Pavlović, Slađan
AU  - Žikić, Radoslav V.
AU  - Štajn, Andraš Š.
AU  - Saičić, Zorica
AU  - Maletić, Snežana
AU  - Radojičić, Ratko
AU  - Petrović, Vojislav M.
PY  - 2002
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5936
AB  - Cadmium (Cd) is an important pollutant of environment which accwnulates in the liver and the kidneys, as well as in other tissues. Cd induces oxidative damage causing many metabolic, histological and pathological changes, such as nephrotoxicity, cardiotoxicity, increased lipid peroxidation (LP) and alteration of the antioxidant defense system (AOS). Recent studies have shown that coenzyme Q10 (CoQ10) and vitamin E (Vit E) are the powerful liposoluble antioxidants, which inhibit lipid peroxidation and thus prevent free radical med.iated oxidative injuries. It is well known that CoQ10 and Vit E may act synergistically as antioxidants. The aim of this study was to investigate a possible protective influence of CoQ10 and Vit E in Cd induced oxidative stress in the rat hearts.
PB  - International Coenzyme Q10 Association
C3  - Programm and Abstracts: Third Conference of the International Coenzyme Q10 Association; 2002 Nov 22-24; London, United Kingdom
T1  - The protective role of coenzyme Q10 and vitamin E on antioxidant defense system in the heart of cadmium treated rats
SP  - 167
EP  - 169
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5936
ER  - 

@conference{
author = "Ognjanović, Branka and Pavlović, Slađan and Žikić, Radoslav V. and Štajn, Andraš Š. and Saičić, Zorica and Maletić, Snežana and Radojičić, Ratko and Petrović, Vojislav M.",
year = "2002",
abstract = "Cadmium (Cd) is an important pollutant of environment which accwnulates in the liver and the kidneys, as well as in other tissues. Cd induces oxidative damage causing many metabolic, histological and pathological changes, such as nephrotoxicity, cardiotoxicity, increased lipid peroxidation (LP) and alteration of the antioxidant defense system (AOS). Recent studies have shown that coenzyme Q10 (CoQ10) and vitamin E (Vit E) are the powerful liposoluble antioxidants, which inhibit lipid peroxidation and thus prevent free radical med.iated oxidative injuries. It is well known that CoQ10 and Vit E may act synergistically as antioxidants. The aim of this study was to investigate a possible protective influence of CoQ10 and Vit E in Cd induced oxidative stress in the rat hearts.",
publisher = "International Coenzyme Q10 Association",
journal = "Programm and Abstracts: Third Conference of the International Coenzyme Q10 Association; 2002 Nov 22-24; London, United Kingdom",
title = "The protective role of coenzyme Q10 and vitamin E on antioxidant defense system in the heart of cadmium treated rats",
pages = "167-169",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5936"
}

Ognjanović, B., Pavlović, S., Žikić, R. V., Štajn, A. Š., Saičić, Z., Maletić, S., Radojičić, R.,& Petrović, V. M.. (2002). The protective role of coenzyme Q10 and vitamin E on antioxidant defense system in the heart of cadmium treated rats. in Programm and Abstracts: Third Conference of the International Coenzyme Q10 Association; 2002 Nov 22-24; London, United Kingdom
International Coenzyme Q10 Association., 167-169.
https://hdl.handle.net/21.15107/rcub_ibiss_5936

Ognjanović B, Pavlović S, Žikić RV, Štajn AŠ, Saičić Z, Maletić S, Radojičić R, Petrović VM. The protective role of coenzyme Q10 and vitamin E on antioxidant defense system in the heart of cadmium treated rats. in Programm and Abstracts: Third Conference of the International Coenzyme Q10 Association; 2002 Nov 22-24; London, United Kingdom. 2002;:167-169.
https://hdl.handle.net/21.15107/rcub_ibiss_5936 .

Ognjanović, Branka, Pavlović, Slađan, Žikić, Radoslav V., Štajn, Andraš Š., Saičić, Zorica, Maletić, Snežana, Radojičić, Ratko, Petrović, Vojislav M., "The protective role of coenzyme Q10 and vitamin E on antioxidant defense system in the heart of cadmium treated rats" in Programm and Abstracts: Third Conference of the International Coenzyme Q10 Association; 2002 Nov 22-24; London, United Kingdom (2002):167-169,
https://hdl.handle.net/21.15107/rcub_ibiss_5936 .

TY  - CONF
AU  - Žikić, Radoslav V.
AU  - Ognjanović, Branka
AU  - Štajn, Andraš Š.
AU  - Pavlović, Slađan
AU  - Saičić, Zorica
AU  - Petrović, Vojislav M.
PY  - 2002
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5916
AB  - Postojeci medjunarodni propisi, standardi i direktive koji se odnose na kvalitet harne su dobrim delom ugradjeni u jugoslovensko zakonodavstvo i propise. Njihovo dosledno postovanje je neophodno ne  samo zbog zadovoljenja kvaliteta hrane koja se distribuira na domacem tzistu vec je i preduslov nase uspesne izvome orijemacije i konkurenmosti na inostranom trzistu prehrambenih proizvoda. Istrazivanja oksidacione stabilnosti hrane koja se sprovode u mnogim istrazivackim laboratorijama u svetu namecu potrebu uvodjenja novih kriterijuma i standarda koji bi obuhvatili i odredjivanje antioksidacionih komponenata u hrani. Rezultati dobijeni u nasim istrazivanjima pokazuju da naknadnim dodavanjem pojedinih komponenata antioksidacionog sistema (selen) moze znacajno da se poveca ukupni nivo ostalih antioksidanata u tkivima eksperimentalnih zivotinja.
PB  - Zaječar : Organizacioni odbor "Ekološke istine 2002"
C3  - Zbornik radova: X naučno-stručni skup o prirodnim vrednostima i zaštiti životne sredine [i] XV stručni sastanak preventivne medicine Timočke Krajine: Ekološka istina; 2002 Jun 5-8; Donji Milanovac, Serbia
T1  - Biološki značaj selena - važan faktor visoko kvalitetne hrane
SP  - 157
EP  - 160
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5916
ER  - 

@conference{
author = "Žikić, Radoslav V. and Ognjanović, Branka and Štajn, Andraš Š. and Pavlović, Slađan and Saičić, Zorica and Petrović, Vojislav M.",
year = "2002",
abstract = "Postojeci medjunarodni propisi, standardi i direktive koji se odnose na kvalitet harne su dobrim delom ugradjeni u jugoslovensko zakonodavstvo i propise. Njihovo dosledno postovanje je neophodno ne  samo zbog zadovoljenja kvaliteta hrane koja se distribuira na domacem tzistu vec je i preduslov nase uspesne izvome orijemacije i konkurenmosti na inostranom trzistu prehrambenih proizvoda. Istrazivanja oksidacione stabilnosti hrane koja se sprovode u mnogim istrazivackim laboratorijama u svetu namecu potrebu uvodjenja novih kriterijuma i standarda koji bi obuhvatili i odredjivanje antioksidacionih komponenata u hrani. Rezultati dobijeni u nasim istrazivanjima pokazuju da naknadnim dodavanjem pojedinih komponenata antioksidacionog sistema (selen) moze znacajno da se poveca ukupni nivo ostalih antioksidanata u tkivima eksperimentalnih zivotinja.",
publisher = "Zaječar : Organizacioni odbor "Ekološke istine 2002"",
journal = "Zbornik radova: X naučno-stručni skup o prirodnim vrednostima i zaštiti životne sredine [i] XV stručni sastanak preventivne medicine Timočke Krajine: Ekološka istina; 2002 Jun 5-8; Donji Milanovac, Serbia",
title = "Biološki značaj selena - važan faktor visoko kvalitetne hrane",
pages = "157-160",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5916"
}

Žikić, R. V., Ognjanović, B., Štajn, A. Š., Pavlović, S., Saičić, Z.,& Petrović, V. M.. (2002). Biološki značaj selena - važan faktor visoko kvalitetne hrane. in Zbornik radova: X naučno-stručni skup o prirodnim vrednostima i zaštiti životne sredine [i] XV stručni sastanak preventivne medicine Timočke Krajine: Ekološka istina; 2002 Jun 5-8; Donji Milanovac, Serbia
Zaječar : Organizacioni odbor "Ekološke istine 2002"., 157-160.
https://hdl.handle.net/21.15107/rcub_ibiss_5916

Žikić RV, Ognjanović B, Štajn AŠ, Pavlović S, Saičić Z, Petrović VM. Biološki značaj selena - važan faktor visoko kvalitetne hrane. in Zbornik radova: X naučno-stručni skup o prirodnim vrednostima i zaštiti životne sredine [i] XV stručni sastanak preventivne medicine Timočke Krajine: Ekološka istina; 2002 Jun 5-8; Donji Milanovac, Serbia. 2002;:157-160.
https://hdl.handle.net/21.15107/rcub_ibiss_5916 .

Žikić, Radoslav V., Ognjanović, Branka, Štajn, Andraš Š., Pavlović, Slađan, Saičić, Zorica, Petrović, Vojislav M., "Biološki značaj selena - važan faktor visoko kvalitetne hrane" in Zbornik radova: X naučno-stručni skup o prirodnim vrednostima i zaštiti životne sredine [i] XV stručni sastanak preventivne medicine Timočke Krajine: Ekološka istina; 2002 Jun 5-8; Donji Milanovac, Serbia (2002):157-160,
https://hdl.handle.net/21.15107/rcub_ibiss_5916 .

TY  - JOUR
AU  - Štajn, Andraš Š.
AU  - Žikić, Radoslav V.
AU  - Mihajlović, Ranđel P.
AU  - Mandić, Sreten
AU  - Ognjanović, Branka
AU  - Pavlović, Slađan
AU  - Saičić, Zorica
AU  - Petrović, Vojislav M.
PY  - 2002
UR  - http://www.studiamarina.ac.me/pdf/23/MUSSELS%20AS%20BIOIDICATORS%20OF%20PRESENCE%20OF%20HEAVY%20METALS%20IN%20BOKA%20KOTORSKA%20BAY.pdf
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5900
AB  - Rapid  urbanization  and  eutrophization,  disturbing  normal  ecological equilibrium of water ecosystems and directly endangering living organisms is the main problem in Boka Kotorska bay. Mediterranean mussel (Mytilus galloprovincialis, Bivalvia, Mollusca) is a species which naturally inhabits the waters of Boka Kotorska bay, but it is artificially bred and increasingly used in human diet. We established that the presence of heavy metals in sea water even in allowed concentrations caused increased accumulation in tissues of mussel (Cu, Mn, Cr, Ni, Al, Mg, Zn, Cd, Pb) pointing to a numerous negative consequences not only in those organisms but in humans, potential consumers of mussels as well.
PB  - Kotor: Institute of Marine Biology, University of Montenegro
T2  - Studia Marina
T1  - Dagnje (Mytillus galloprovintialis) kao bioindikatori prisustva teških metala u Bokokotorskom zalivu
T1  - Mussels (Mytilus galloprovincialis) as bioindicators of presence of heavy metals in Boka Kotorska Bay
IS  - 1
VL  - 23
SP  - 87
EP  - 94
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5900
ER  - 

@article{
author = "Štajn, Andraš Š. and Žikić, Radoslav V. and Mihajlović, Ranđel P. and Mandić, Sreten and Ognjanović, Branka and Pavlović, Slađan and Saičić, Zorica and Petrović, Vojislav M.",
year = "2002",
abstract = "Rapid  urbanization  and  eutrophization,  disturbing  normal  ecological equilibrium of water ecosystems and directly endangering living organisms is the main problem in Boka Kotorska bay. Mediterranean mussel (Mytilus galloprovincialis, Bivalvia, Mollusca) is a species which naturally inhabits the waters of Boka Kotorska bay, but it is artificially bred and increasingly used in human diet. We established that the presence of heavy metals in sea water even in allowed concentrations caused increased accumulation in tissues of mussel (Cu, Mn, Cr, Ni, Al, Mg, Zn, Cd, Pb) pointing to a numerous negative consequences not only in those organisms but in humans, potential consumers of mussels as well.",
publisher = "Kotor: Institute of Marine Biology, University of Montenegro",
journal = "Studia Marina",
title = "Dagnje (Mytillus galloprovintialis) kao bioindikatori prisustva teških metala u Bokokotorskom zalivu, Mussels (Mytilus galloprovincialis) as bioindicators of presence of heavy metals in Boka Kotorska Bay",
number = "1",
volume = "23",
pages = "87-94",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5900"
}

Štajn, A. Š., Žikić, R. V., Mihajlović, R. P., Mandić, S., Ognjanović, B., Pavlović, S., Saičić, Z.,& Petrović, V. M.. (2002). Dagnje (Mytillus galloprovintialis) kao bioindikatori prisustva teških metala u Bokokotorskom zalivu. in Studia Marina
Kotor: Institute of Marine Biology, University of Montenegro., 23(1), 87-94.
https://hdl.handle.net/21.15107/rcub_ibiss_5900

Štajn AŠ, Žikić RV, Mihajlović RP, Mandić S, Ognjanović B, Pavlović S, Saičić Z, Petrović VM. Dagnje (Mytillus galloprovintialis) kao bioindikatori prisustva teških metala u Bokokotorskom zalivu. in Studia Marina. 2002;23(1):87-94.
https://hdl.handle.net/21.15107/rcub_ibiss_5900 .

Štajn, Andraš Š., Žikić, Radoslav V., Mihajlović, Ranđel P., Mandić, Sreten, Ognjanović, Branka, Pavlović, Slađan, Saičić, Zorica, Petrović, Vojislav M., "Dagnje (Mytillus galloprovintialis) kao bioindikatori prisustva teških metala u Bokokotorskom zalivu" in Studia Marina, 23, no. 1 (2002):87-94,
https://hdl.handle.net/21.15107/rcub_ibiss_5900 .

TY  - CONF
AU  - Ognjanović, Branka
AU  - Pavlović, Slađan
AU  - Petrović, Vojislav M.
AU  - Saičić, Zorica
AU  - Štajn, Andraš Š.
AU  - Žikić, Radoslav V.
PY  - 2001
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6119
AB  - Coenzyme Q (CoQ) is present in almost all living organisms where it exhibits antioxidant properties and also represents an obligatory component of the mitochondrial respiratory chain (2). CoQ may prevent lipide peroxidation, protects DNA from oxidation and protects organism from oxidative stress induced by various toxic agents (1). The scope of our study was to investigate the concentrations of  ascorbic acid (AsA) and vitamin  E (Vit E) in the liver, kidneys, heart and testes,   as well as CoQ concentration in the liver, kidneys and testes of male, two months old Wistar albino rats treated with 20 mg/kg of coenzyme Q10 (CoQ10) dissolved in olive oil, i.m., every fifth  day, during 30 days. An average intake of CoQ10 was 16 mg/kg/dose. All  obtained  results  were  compared with control animals  (C).
Our results show that treatment with CoQ10 induced a significant increase of AsA and Vit E concentrations in all investigated tissues. The concentration  of  CoQ  was  significantly  increased only in the liver of rats treated with CoQ10. It is well known that CoQ10 in  its  reduced  form (CoQ10H2) is the powerful antioxidant which regenerate the active form of Vit E from the Vit E radicals (tocopheroxyl radicals, Vit E"), (4), stabilized extracellular ascorbate by its NADPH-CoQ10 reductase (3) and elevate the endogenous CoQ pool in the cells (1). At the other hand, dose and time dependent studies were shown that CoQ concentration after parenteral administration was increased only in the plasma and liver ofrats  (5).It can be concluded that all obtained  effects induced by CoQ10  led to the elevated concentrations  of non-enzymatic components of antioxidant defense system and increased antioxidant protection of all examined tissues.
PB  - IUPs New Zealand
C3  - 34th International Congress of Physiological Sciences; 2001 Aug 26-31; Christchurch, New Zealand
T1  - Non-enzymatic components of antioxidant defense system in some tissues of rats treated with coenzyme Q10
SP  - 1163
EP  - 1163
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_6119
ER  - 

@conference{
author = "Ognjanović, Branka and Pavlović, Slađan and Petrović, Vojislav M. and Saičić, Zorica and Štajn, Andraš Š. and Žikić, Radoslav V.",
year = "2001",
abstract = "Coenzyme Q (CoQ) is present in almost all living organisms where it exhibits antioxidant properties and also represents an obligatory component of the mitochondrial respiratory chain (2). CoQ may prevent lipide peroxidation, protects DNA from oxidation and protects organism from oxidative stress induced by various toxic agents (1). The scope of our study was to investigate the concentrations of  ascorbic acid (AsA) and vitamin  E (Vit E) in the liver, kidneys, heart and testes,   as well as CoQ concentration in the liver, kidneys and testes of male, two months old Wistar albino rats treated with 20 mg/kg of coenzyme Q10 (CoQ10) dissolved in olive oil, i.m., every fifth  day, during 30 days. An average intake of CoQ10 was 16 mg/kg/dose. All  obtained  results  were  compared with control animals  (C).
Our results show that treatment with CoQ10 induced a significant increase of AsA and Vit E concentrations in all investigated tissues. The concentration  of  CoQ  was  significantly  increased only in the liver of rats treated with CoQ10. It is well known that CoQ10 in  its  reduced  form (CoQ10H2) is the powerful antioxidant which regenerate the active form of Vit E from the Vit E radicals (tocopheroxyl radicals, Vit E"), (4), stabilized extracellular ascorbate by its NADPH-CoQ10 reductase (3) and elevate the endogenous CoQ pool in the cells (1). At the other hand, dose and time dependent studies were shown that CoQ concentration after parenteral administration was increased only in the plasma and liver ofrats  (5).It can be concluded that all obtained  effects induced by CoQ10  led to the elevated concentrations  of non-enzymatic components of antioxidant defense system and increased antioxidant protection of all examined tissues.",
publisher = "IUPs New Zealand",
journal = "34th International Congress of Physiological Sciences; 2001 Aug 26-31; Christchurch, New Zealand",
title = "Non-enzymatic components of antioxidant defense system in some tissues of rats treated with coenzyme Q10",
pages = "1163-1163",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_6119"
}

Ognjanović, B., Pavlović, S., Petrović, V. M., Saičić, Z., Štajn, A. Š.,& Žikić, R. V.. (2001). Non-enzymatic components of antioxidant defense system in some tissues of rats treated with coenzyme Q10. in 34th International Congress of Physiological Sciences; 2001 Aug 26-31; Christchurch, New Zealand
IUPs New Zealand., 1163-1163.
https://hdl.handle.net/21.15107/rcub_ibiss_6119

Ognjanović B, Pavlović S, Petrović VM, Saičić Z, Štajn AŠ, Žikić RV. Non-enzymatic components of antioxidant defense system in some tissues of rats treated with coenzyme Q10. in 34th International Congress of Physiological Sciences; 2001 Aug 26-31; Christchurch, New Zealand. 2001;:1163-1163.
https://hdl.handle.net/21.15107/rcub_ibiss_6119 .

Ognjanović, Branka, Pavlović, Slađan, Petrović, Vojislav M., Saičić, Zorica, Štajn, Andraš Š., Žikić, Radoslav V., "Non-enzymatic components of antioxidant defense system in some tissues of rats treated with coenzyme Q10" in 34th International Congress of Physiological Sciences; 2001 Aug 26-31; Christchurch, New Zealand (2001):1163-1163,
https://hdl.handle.net/21.15107/rcub_ibiss_6119 .

TY  - CONF
AU  - Saičić, Zorica
AU  - Pavlović, Slađan
AU  - Ognjanović, Branka
AU  - Štajn, Andraš Š.
AU  - Žikić, Radoslav V.
AU  - Petrović, Vojislav M.
PY  - 2001
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6117
AB  - The aim of our study was to investigate the activities of copper zinc containing superoxide dismutase (CuZn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione-S-transferase (GST) and glutathione reductase (GR), as well as ascorbic acid (AsA), vitamin E (Vit E) and lipide peroxide (LP) concentrations in the blood of male two months old Wistar albino rats. The animals were divided as follows: (1) untreated controls (C); (2) animals treated with 14 mg/day/kg b.m. cadmium in drinking water during 15 days (Cd); (3) rats treated with 20 IU/kg/dose of Vit E and 15 mg/kg/dose of coenzyme Q10 (CoQ10), i.m., every fifth day during 15 days (Vit E+CoQ10) and (4) animals pretreated with Vit E and CoQ10 in above mentioned amounts during 15 days and then treated with 14 mg/day/kg b.m. of Cd during next 15 days (Cd+Vit E+CoQ10). Each group consisted of seven animals.               All obtained results were compared in respect to the control animals.
   Cadmium induced a significant increase of GST activity, as well as Vit E concentration in the plasma. In Vit E+CoQ10 treated animals the activities of GSH-Px and GR in erythrocytes were significantly decreased, whereas plasma AsA and Vit E concentrations were markedly elevated.          In Cd+Vit E+CoQ10 treated rats erythrocyte GSH-Px and GR activities, as well as plasma Vit E concentration were significantly increased, while plasma AsA concentration was significantly decreased. In all examined groups of animals LP concentration in the whole blood was significantly decreased. The obtained results show that Cd in the dosages administered influenced antioxidant defense system in the blood of rats and the protective role of Vit E and CoQ10 against Cd toxicity was also observed.
PB  - Society for Free Radical Research - Africa
C3  - Conference Book of Abstracts: 2nd International Conference of the Society for Free Radical Research-Africa; 2001 Jul 15-19; Maui, Mauritius
T1  - Protective role of vitamin E and coenzyme Q10 on antioxidant defense system in the blood of rats treated with cadmium
SP  - 56
EP  - 56
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_6117
ER  - 

@conference{
author = "Saičić, Zorica and Pavlović, Slađan and Ognjanović, Branka and Štajn, Andraš Š. and Žikić, Radoslav V. and Petrović, Vojislav M.",
year = "2001",
abstract = "The aim of our study was to investigate the activities of copper zinc containing superoxide dismutase (CuZn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione-S-transferase (GST) and glutathione reductase (GR), as well as ascorbic acid (AsA), vitamin E (Vit E) and lipide peroxide (LP) concentrations in the blood of male two months old Wistar albino rats. The animals were divided as follows: (1) untreated controls (C); (2) animals treated with 14 mg/day/kg b.m. cadmium in drinking water during 15 days (Cd); (3) rats treated with 20 IU/kg/dose of Vit E and 15 mg/kg/dose of coenzyme Q10 (CoQ10), i.m., every fifth day during 15 days (Vit E+CoQ10) and (4) animals pretreated with Vit E and CoQ10 in above mentioned amounts during 15 days and then treated with 14 mg/day/kg b.m. of Cd during next 15 days (Cd+Vit E+CoQ10). Each group consisted of seven animals.               All obtained results were compared in respect to the control animals.
   Cadmium induced a significant increase of GST activity, as well as Vit E concentration in the plasma. In Vit E+CoQ10 treated animals the activities of GSH-Px and GR in erythrocytes were significantly decreased, whereas plasma AsA and Vit E concentrations were markedly elevated.          In Cd+Vit E+CoQ10 treated rats erythrocyte GSH-Px and GR activities, as well as plasma Vit E concentration were significantly increased, while plasma AsA concentration was significantly decreased. In all examined groups of animals LP concentration in the whole blood was significantly decreased. The obtained results show that Cd in the dosages administered influenced antioxidant defense system in the blood of rats and the protective role of Vit E and CoQ10 against Cd toxicity was also observed.",
publisher = "Society for Free Radical Research - Africa",
journal = "Conference Book of Abstracts: 2nd International Conference of the Society for Free Radical Research-Africa; 2001 Jul 15-19; Maui, Mauritius",
title = "Protective role of vitamin E and coenzyme Q10 on antioxidant defense system in the blood of rats treated with cadmium",
pages = "56-56",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_6117"
}

Saičić, Z., Pavlović, S., Ognjanović, B., Štajn, A. Š., Žikić, R. V.,& Petrović, V. M.. (2001). Protective role of vitamin E and coenzyme Q10 on antioxidant defense system in the blood of rats treated with cadmium. in Conference Book of Abstracts: 2nd International Conference of the Society for Free Radical Research-Africa; 2001 Jul 15-19; Maui, Mauritius
Society for Free Radical Research - Africa., 56-56.
https://hdl.handle.net/21.15107/rcub_ibiss_6117

Saičić Z, Pavlović S, Ognjanović B, Štajn AŠ, Žikić RV, Petrović VM. Protective role of vitamin E and coenzyme Q10 on antioxidant defense system in the blood of rats treated with cadmium. in Conference Book of Abstracts: 2nd International Conference of the Society for Free Radical Research-Africa; 2001 Jul 15-19; Maui, Mauritius. 2001;:56-56.
https://hdl.handle.net/21.15107/rcub_ibiss_6117 .

Saičić, Zorica, Pavlović, Slađan, Ognjanović, Branka, Štajn, Andraš Š., Žikić, Radoslav V., Petrović, Vojislav M., "Protective role of vitamin E and coenzyme Q10 on antioxidant defense system in the blood of rats treated with cadmium" in Conference Book of Abstracts: 2nd International Conference of the Society for Free Radical Research-Africa; 2001 Jul 15-19; Maui, Mauritius (2001):56-56,
https://hdl.handle.net/21.15107/rcub_ibiss_6117 .

TY  - CONF
AU  - Pavlović, Slađan
AU  - Ognjanović, Branka
AU  - Štajn, Andraš Š.
AU  - Žikić, Radoslav V.
AU  - Saičić, Zorica
AU  - Petrović, Vojislav M.
PY  - 2001
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6116
AB  - The aim of our study was to investigate the effects of coenzyme Q10 (CoQ10) administration on the  activities  of  superoxide  dismutases: total  (Tot  SOD),  copper  zinc  containing  (CuZn  SOD) and manganese containing (Mn SOD), catalase (CAT), glutathione peroxidase (GSH-Px,) glutathione-S-transferase (GST) and glutathione reductase (GR) in liver, kidneys, heart and testes of male two months old Wistar albino rats. The animals were divided in two experimental groups: (1) control rats (C) and (2) rats treated with 20 mg/kg/dose of coenzyme Q10 by i.m. injections, every fifth day during 30 days  (CoQ10).
An average intake of CoQ10 was 16 mg/kg/dose. All obtained results were compared in respect to the control animals.
The obtained data shows that Tot SOD activity was significantly increased in the heart  of CoQ10 treated animals. At the same time, the activity of CuZn SOD was also increased in the heart, as well as in testes of CoQ10 treated rats. Mn SOD activity was markedly decreased in kidneys and testes, while in heart was significantly increased. The activity of CAT was significantly decreased in liver, kidneys and heart, whereas GSH-Px activity was decreased only in the kidneys of CoQ10 treated animals. At the same time, GSH-Px activity was markedly elevated in heart and testes. Finally, the activity of GR was significantly decreased in the heart of animals received CoQ10.
The obtained results show that CoQ1O in the dosage administered influenced antioxidant enzyme activities in examined tissues of rats. It is also shown that various tissues exhibit different response to CoQ10 depending of their metabolic activity.
PB  - Society for Free Radical Research, European Region
C3  - Program and Abstracts: The Meeting of the Society for Free Radical Research Europe: SFRR 2001; 2001 Jun 22-24; Roma, Italy
T1  - Alterations of antioxidant enzyme activities in tissues of rats treated with coenzyme Q10
SP  - PP38
EP  - PP38
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_6116
ER  - 

@conference{
author = "Pavlović, Slađan and Ognjanović, Branka and Štajn, Andraš Š. and Žikić, Radoslav V. and Saičić, Zorica and Petrović, Vojislav M.",
year = "2001",
abstract = "The aim of our study was to investigate the effects of coenzyme Q10 (CoQ10) administration on the  activities  of  superoxide  dismutases: total  (Tot  SOD),  copper  zinc  containing  (CuZn  SOD) and manganese containing (Mn SOD), catalase (CAT), glutathione peroxidase (GSH-Px,) glutathione-S-transferase (GST) and glutathione reductase (GR) in liver, kidneys, heart and testes of male two months old Wistar albino rats. The animals were divided in two experimental groups: (1) control rats (C) and (2) rats treated with 20 mg/kg/dose of coenzyme Q10 by i.m. injections, every fifth day during 30 days  (CoQ10).
An average intake of CoQ10 was 16 mg/kg/dose. All obtained results were compared in respect to the control animals.
The obtained data shows that Tot SOD activity was significantly increased in the heart  of CoQ10 treated animals. At the same time, the activity of CuZn SOD was also increased in the heart, as well as in testes of CoQ10 treated rats. Mn SOD activity was markedly decreased in kidneys and testes, while in heart was significantly increased. The activity of CAT was significantly decreased in liver, kidneys and heart, whereas GSH-Px activity was decreased only in the kidneys of CoQ10 treated animals. At the same time, GSH-Px activity was markedly elevated in heart and testes. Finally, the activity of GR was significantly decreased in the heart of animals received CoQ10.
The obtained results show that CoQ1O in the dosage administered influenced antioxidant enzyme activities in examined tissues of rats. It is also shown that various tissues exhibit different response to CoQ10 depending of their metabolic activity.",
publisher = "Society for Free Radical Research, European Region",
journal = "Program and Abstracts: The Meeting of the Society for Free Radical Research Europe: SFRR 2001; 2001 Jun 22-24; Roma, Italy",
title = "Alterations of antioxidant enzyme activities in tissues of rats treated with coenzyme Q10",
pages = "PP38-PP38",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_6116"
}

Pavlović, S., Ognjanović, B., Štajn, A. Š., Žikić, R. V., Saičić, Z.,& Petrović, V. M.. (2001). Alterations of antioxidant enzyme activities in tissues of rats treated with coenzyme Q10. in Program and Abstracts: The Meeting of the Society for Free Radical Research Europe: SFRR 2001; 2001 Jun 22-24; Roma, Italy
Society for Free Radical Research, European Region., PP38-PP38.
https://hdl.handle.net/21.15107/rcub_ibiss_6116

Pavlović S, Ognjanović B, Štajn AŠ, Žikić RV, Saičić Z, Petrović VM. Alterations of antioxidant enzyme activities in tissues of rats treated with coenzyme Q10. in Program and Abstracts: The Meeting of the Society for Free Radical Research Europe: SFRR 2001; 2001 Jun 22-24; Roma, Italy. 2001;:PP38-PP38.
https://hdl.handle.net/21.15107/rcub_ibiss_6116 .

Pavlović, Slađan, Ognjanović, Branka, Štajn, Andraš Š., Žikić, Radoslav V., Saičić, Zorica, Petrović, Vojislav M., "Alterations of antioxidant enzyme activities in tissues of rats treated with coenzyme Q10" in Program and Abstracts: The Meeting of the Society for Free Radical Research Europe: SFRR 2001; 2001 Jun 22-24; Roma, Italy (2001):PP38-PP38,
https://hdl.handle.net/21.15107/rcub_ibiss_6116 .