TY  - JOUR
AU  - Scanavacca, Juliana
AU  - Bortolucci, Wanessa de Campos
AU  - Jacomassi, Ezilda
AU  - Baretta, Irineia Paulina
AU  - Faria, Maria Graciela Iecher
AU  - Fernandez, Carla Maria Mariano
AU  - Tešević, Vele
AU  - Glamočlija, Jasmina
AU  - Soković, Marina
AU  - Colauto, Nelson Barros
AU  - Linde, Giani Andrea
AU  - Gazim, Zilda Cristiani
PY  - 2023
UR  - https://blacpma.ms-editions.cl/index.php/blacpma/article/view/337/345
UR  - https://blacpma.ms-editions.cl/index.php/blacpma/article/view/337
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5233
AB  - Food spoilage is a widely neglected problem and the constant use of synthetic fungicides could develop resistant fungi. The objective of this study was to evaluate the chemical composition and antimicrobial activity of Tetradenia riparia leaf essential oil against foodborne disease microorganisms. Leaf essential oil was obtained by hydrodistillation and identified by gas chromatography coupled to mass spectrometry. The antimicrobial activity was studied by broth microdilution. The major compounds identified were oxygenated sesquiterpenes (43.6%): 14-hydroxy-9-epi-(E)-cariophylene (20.8%) and τ-cadinol (18.4%); followed by oxygenated diterpenes (24.6%): 6,7-dehydroroyleanone (12.6%) and 9β, 13β-epoxy-7-abiethene (10.6%); sesquiterpenic hydrocarbons (17.1%) and oxygenated monoterpenes (7.4%): fenchone (5.6%). The essential oil had broad antibacterial and antifungal activity, mainly against A. versicolor and P. ochrochloron with fungistatic and fungicidal activities and B. cereus, L. monocytogenes, and S. aureus with bacteriostatic and bactericidal activities. T. riparia leaf essential oil is a potential alternative to control microorganisms.
PB  - MS-Editions
T2  - Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas
T1  - Antimicrobial activity of Tetradenia riparia leaf essential oil
IS  - 2
VL  - 22
DO  - 10.37360/blacpma.23.22.2.19
SP  - 255
EP  - 267
ER  - 

@article{
author = "Scanavacca, Juliana and Bortolucci, Wanessa de Campos and Jacomassi, Ezilda and Baretta, Irineia Paulina and Faria, Maria Graciela Iecher and Fernandez, Carla Maria Mariano and Tešević, Vele and Glamočlija, Jasmina and Soković, Marina and Colauto, Nelson Barros and Linde, Giani Andrea and Gazim, Zilda Cristiani",
year = "2023",
abstract = "Food spoilage is a widely neglected problem and the constant use of synthetic fungicides could develop resistant fungi. The objective of this study was to evaluate the chemical composition and antimicrobial activity of Tetradenia riparia leaf essential oil against foodborne disease microorganisms. Leaf essential oil was obtained by hydrodistillation and identified by gas chromatography coupled to mass spectrometry. The antimicrobial activity was studied by broth microdilution. The major compounds identified were oxygenated sesquiterpenes (43.6%): 14-hydroxy-9-epi-(E)-cariophylene (20.8%) and τ-cadinol (18.4%); followed by oxygenated diterpenes (24.6%): 6,7-dehydroroyleanone (12.6%) and 9β, 13β-epoxy-7-abiethene (10.6%); sesquiterpenic hydrocarbons (17.1%) and oxygenated monoterpenes (7.4%): fenchone (5.6%). The essential oil had broad antibacterial and antifungal activity, mainly against A. versicolor and P. ochrochloron with fungistatic and fungicidal activities and B. cereus, L. monocytogenes, and S. aureus with bacteriostatic and bactericidal activities. T. riparia leaf essential oil is a potential alternative to control microorganisms.",
publisher = "MS-Editions",
journal = "Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas",
title = "Antimicrobial activity of Tetradenia riparia leaf essential oil",
number = "2",
volume = "22",
doi = "10.37360/blacpma.23.22.2.19",
pages = "255-267"
}

Scanavacca, J., Bortolucci, W. d. C., Jacomassi, E., Baretta, I. P., Faria, M. G. I., Fernandez, C. M. M., Tešević, V., Glamočlija, J., Soković, M., Colauto, N. B., Linde, G. A.,& Gazim, Z. C.. (2023). Antimicrobial activity of Tetradenia riparia leaf essential oil. in Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas
MS-Editions., 22(2), 255-267.
https://doi.org/10.37360/blacpma.23.22.2.19

Scanavacca J, Bortolucci WDC, Jacomassi E, Baretta IP, Faria MGI, Fernandez CMM, Tešević V, Glamočlija J, Soković M, Colauto NB, Linde GA, Gazim ZC. Antimicrobial activity of Tetradenia riparia leaf essential oil. in Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas. 2023;22(2):255-267.
doi:10.37360/blacpma.23.22.2.19 .

Scanavacca, Juliana, Bortolucci, Wanessa de Campos, Jacomassi, Ezilda, Baretta, Irineia Paulina, Faria, Maria Graciela Iecher, Fernandez, Carla Maria Mariano, Tešević, Vele, Glamočlija, Jasmina, Soković, Marina, Colauto, Nelson Barros, Linde, Giani Andrea, Gazim, Zilda Cristiani, "Antimicrobial activity of Tetradenia riparia leaf essential oil" in Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas, 22, no. 2 (2023):255-267,
https://doi.org/10.37360/blacpma.23.22.2.19 . .

TY  - JOUR
AU  - Añibarro-Ortega, Mikel
AU  - Pinela, José
AU  - Ćirić, Ana
AU  - Lopes, Elsa
AU  - Molina, Adriana K.
AU  - Calhelha, Ricardo C.
AU  - Soković, Marina
AU  - Ferreira, Olga
AU  - Ferreira, Isabel C. F. R.
AU  - Barros, Lillian
PY  - 2021
UR  - https://www.mdpi.com/2079-7737/10/10/951
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4488
AB  - Aloesin is an aromatic chromone with increasing applications in the cosmetic and health food industries. To optimize its extraction from the Aloe vera leaf rind, the independent variables time (10–210 min), temperature (25–95 °C) and organic solvent composition (0–100%, w/w) were combined in a central composite design coupled with response surface methodology. The solvents consisted of binary mixtures of water with ethanol, propylene glycol, or glycerol. The aloesin levels quantified in each extract were used as response for optimization. The theoretical models were fitted to the experimental data, statistically validated, and used to obtain the optimal extraction conditions. Then, a dose–response analysis of the solid/liquid ratio (S/L) was performed under the optimal conditions determined for each alcohol–water system and revealed that a linear improvement in extraction efficiency can be achieved by increasing the S/L ratio by up to 40 g/L. This analysis also allowed to experimentally validate the predictive models. Furthermore, the aloesin-rich extracts revealed antioxidant activity through thiobarbituric acid reactive substances (TBARS) formation inhibition, antimicrobial effects against bacterial and fungal strains, and no toxicity for PLP2 cells. Overall, this study provided optimal extraction conditions for the recovery of aloesin from Aloe vera rind through an eco-friendly extraction process and highlighted its bioactive potential.
PB  - Basel: MDPI
T2  - Biology
T1  - Extraction of Aloesin from Aloe vera Rind Using Alternative Green Solvents: Process Optimization and Biological Activity Assessment
IS  - 10
VL  - 10
DO  - 10.3390/biology10100951
SP  - 951
ER  - 

@article{
author = "Añibarro-Ortega, Mikel and Pinela, José and Ćirić, Ana and Lopes, Elsa and Molina, Adriana K. and Calhelha, Ricardo C. and Soković, Marina and Ferreira, Olga and Ferreira, Isabel C. F. R. and Barros, Lillian",
year = "2021",
abstract = "Aloesin is an aromatic chromone with increasing applications in the cosmetic and health food industries. To optimize its extraction from the Aloe vera leaf rind, the independent variables time (10–210 min), temperature (25–95 °C) and organic solvent composition (0–100%, w/w) were combined in a central composite design coupled with response surface methodology. The solvents consisted of binary mixtures of water with ethanol, propylene glycol, or glycerol. The aloesin levels quantified in each extract were used as response for optimization. The theoretical models were fitted to the experimental data, statistically validated, and used to obtain the optimal extraction conditions. Then, a dose–response analysis of the solid/liquid ratio (S/L) was performed under the optimal conditions determined for each alcohol–water system and revealed that a linear improvement in extraction efficiency can be achieved by increasing the S/L ratio by up to 40 g/L. This analysis also allowed to experimentally validate the predictive models. Furthermore, the aloesin-rich extracts revealed antioxidant activity through thiobarbituric acid reactive substances (TBARS) formation inhibition, antimicrobial effects against bacterial and fungal strains, and no toxicity for PLP2 cells. Overall, this study provided optimal extraction conditions for the recovery of aloesin from Aloe vera rind through an eco-friendly extraction process and highlighted its bioactive potential.",
publisher = "Basel: MDPI",
journal = "Biology",
title = "Extraction of Aloesin from Aloe vera Rind Using Alternative Green Solvents: Process Optimization and Biological Activity Assessment",
number = "10",
volume = "10",
doi = "10.3390/biology10100951",
pages = "951"
}

Añibarro-Ortega, M., Pinela, J., Ćirić, A., Lopes, E., Molina, A. K., Calhelha, R. C., Soković, M., Ferreira, O., Ferreira, I. C. F. R.,& Barros, L.. (2021). Extraction of Aloesin from Aloe vera Rind Using Alternative Green Solvents: Process Optimization and Biological Activity Assessment. in Biology
Basel: MDPI., 10(10), 951.
https://doi.org/10.3390/biology10100951

Añibarro-Ortega M, Pinela J, Ćirić A, Lopes E, Molina AK, Calhelha RC, Soković M, Ferreira O, Ferreira ICFR, Barros L. Extraction of Aloesin from Aloe vera Rind Using Alternative Green Solvents: Process Optimization and Biological Activity Assessment. in Biology. 2021;10(10):951.
doi:10.3390/biology10100951 .

Añibarro-Ortega, Mikel, Pinela, José, Ćirić, Ana, Lopes, Elsa, Molina, Adriana K., Calhelha, Ricardo C., Soković, Marina, Ferreira, Olga, Ferreira, Isabel C. F. R., Barros, Lillian, "Extraction of Aloesin from Aloe vera Rind Using Alternative Green Solvents: Process Optimization and Biological Activity Assessment" in Biology, 10, no. 10 (2021):951,
https://doi.org/10.3390/biology10100951 . .

TY  - THES
AU  - Kostić, Marina
PY  - 2021
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/4666
AB  - Za ispitivanje potencijala prirodnih proizvoda u tretmanu hroničnog tonzilitisa odabrano je 7 vrsta makromiceta (Armillaria mellea, Lactarius piperatus, L. quietus, L. vellereus, Russula integra, R. nigricans i R. rosea) i 2 komercijalna etarska ulja (Origanum minutiflorum i Coriandrum sativum). U disertaciji je analiziran hemijski sastav i biološka aktivnost ekstrakata plodonosnih tela makromiceta i etarskih ulja. Hemijska analiza ekstrakata makromiceta je pokazala da imaju povoljan nutritivni profil (visok sadržaj uljenih hidrata i proteina, nizak sadržaj masti). Najzastupljeniji šećer je manitol, dok su izoforme tokoferola različito zastupljene zavisno od testirane vrste. Analiza masnih kiselina je pokazala visoku zastupljenost linolne, oleinske i stearinske kiseline, dok je među organskim najzastupljenija jabučna, među fenolnim p-hidroksibenzoeva kiselina. Hemijska analiza etarskih ulja je pokazala da je karvakrol najzastupljenije jedinjenje divljeg origana, dok je u slučaju etarskog ulja korijandera to linalol. Antibakterijska aktivnost je testirana na 16 različitih vrsta bakterija izolovanih iz uzoraka nepčanih tonzila i adenoida pacijenata sa dijagnostifikovanim hroničnim tonzilitisom i identifikovanih. Ekstrakti makromiceta su pokazali umerenu antibakterijsku aktivnost, dok su etarska ulja pokazala znatno bolju aktivnost. Antioksidativna aktivnost određena TBARS metodom je pokazala da ekstrakti testiranih makromiceta, kao i etarsko ulje divljeg origana poseduju dobru antioksidativnu aktivnost u in vitro uslovima; aktivnost merena OxHLIA metodom je pokazala visok antioksidativni potencijal ali samo za vrste L. vellereus, R. integra i R. nigricans. Dobar citotoksični potencijal na tumorsku ćelijsku liniju NCI–H460 pokazao je etanolni ekstrakt L. vellereus kao i oba testirana etarska ulja.
AB  - For the investigation of natural products potential in the treatment of chronic tonsillitis, 7 species of macromycetes (Armillaria mellea, Lactarius piperatus, L. quietus, L. vellereus, Russula integra, R. nigricans i R. rosea) and 2 commercial essential oils (Origanum minutiflorum and Coriandrum sativum) were selected. Their chemical composition and biological activity were evaluated. Chemical analysis of extracts from fruiting bodies has shown they have a favorable nutritional profile (high content of carbohydrates and proteins, with low lipids content). The most common sugar was mannitol, while content of tocopherol isoforms was varied on the tested macromycetes species. The fatty acids analysis revealed high presence of linoleic, oleic and stearic acid, among the organic acids, malic acid was the most abundant, whereas p-hydroxybenzoic acid was the most predominant among phenolic acids. Regarding chemical analysis of essential oils, analysis showed that carvacrol was the most common compound in the wild growing oregano oil, while in case of coriander that was linalool. Antibacterial activity was evaluated on 16 different strains isolated from tissue samples of palatine tonsils and adenoids from patients diagnosed with chronic tonsillitis and identified. Macromycetes extracts showed moderate antibacterial activity, while tested essential oils exerted significantly better activity. Antioxidant activity determinated by TBARS method showed that the tested extracts, as well as wild oregano essential oil possess good in vitro antioxidant activity; while activity measured by OxHLIA method showed high antioxidant potential but only for L. vellereus, R. integra and R. nigricans samples. As for the cytotoxic potential towards tumor cell line NCI – H460 L.
PB  - Belgrade: Faculty of Biology, University of Belgrade
T2  - Faculty of Biology; University of Belgrade
T1  - Hemijski sastav ekstrakata makromiceta i etarskih ulja divljeg origana i korijandera i njihov in vitro potencijal u tretmanu uzročnika hroničnog tonzilitisa
T1  - Chemical composition of macromycetes extracts, wild oregano and coriander essential oils and their in vitro potential in the treatment of chronic tonsillitis causative agents
SP  - 1
EP  - 111
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_4666
ER  - 

@phdthesis{
author = "Kostić, Marina",
year = "2021",
abstract = "Za ispitivanje potencijala prirodnih proizvoda u tretmanu hroničnog tonzilitisa odabrano je 7 vrsta makromiceta (Armillaria mellea, Lactarius piperatus, L. quietus, L. vellereus, Russula integra, R. nigricans i R. rosea) i 2 komercijalna etarska ulja (Origanum minutiflorum i Coriandrum sativum). U disertaciji je analiziran hemijski sastav i biološka aktivnost ekstrakata plodonosnih tela makromiceta i etarskih ulja. Hemijska analiza ekstrakata makromiceta je pokazala da imaju povoljan nutritivni profil (visok sadržaj uljenih hidrata i proteina, nizak sadržaj masti). Najzastupljeniji šećer je manitol, dok su izoforme tokoferola različito zastupljene zavisno od testirane vrste. Analiza masnih kiselina je pokazala visoku zastupljenost linolne, oleinske i stearinske kiseline, dok je među organskim najzastupljenija jabučna, među fenolnim p-hidroksibenzoeva kiselina. Hemijska analiza etarskih ulja je pokazala da je karvakrol najzastupljenije jedinjenje divljeg origana, dok je u slučaju etarskog ulja korijandera to linalol. Antibakterijska aktivnost je testirana na 16 različitih vrsta bakterija izolovanih iz uzoraka nepčanih tonzila i adenoida pacijenata sa dijagnostifikovanim hroničnim tonzilitisom i identifikovanih. Ekstrakti makromiceta su pokazali umerenu antibakterijsku aktivnost, dok su etarska ulja pokazala znatno bolju aktivnost. Antioksidativna aktivnost određena TBARS metodom je pokazala da ekstrakti testiranih makromiceta, kao i etarsko ulje divljeg origana poseduju dobru antioksidativnu aktivnost u in vitro uslovima; aktivnost merena OxHLIA metodom je pokazala visok antioksidativni potencijal ali samo za vrste L. vellereus, R. integra i R. nigricans. Dobar citotoksični potencijal na tumorsku ćelijsku liniju NCI–H460 pokazao je etanolni ekstrakt L. vellereus kao i oba testirana etarska ulja., For the investigation of natural products potential in the treatment of chronic tonsillitis, 7 species of macromycetes (Armillaria mellea, Lactarius piperatus, L. quietus, L. vellereus, Russula integra, R. nigricans i R. rosea) and 2 commercial essential oils (Origanum minutiflorum and Coriandrum sativum) were selected. Their chemical composition and biological activity were evaluated. Chemical analysis of extracts from fruiting bodies has shown they have a favorable nutritional profile (high content of carbohydrates and proteins, with low lipids content). The most common sugar was mannitol, while content of tocopherol isoforms was varied on the tested macromycetes species. The fatty acids analysis revealed high presence of linoleic, oleic and stearic acid, among the organic acids, malic acid was the most abundant, whereas p-hydroxybenzoic acid was the most predominant among phenolic acids. Regarding chemical analysis of essential oils, analysis showed that carvacrol was the most common compound in the wild growing oregano oil, while in case of coriander that was linalool. Antibacterial activity was evaluated on 16 different strains isolated from tissue samples of palatine tonsils and adenoids from patients diagnosed with chronic tonsillitis and identified. Macromycetes extracts showed moderate antibacterial activity, while tested essential oils exerted significantly better activity. Antioxidant activity determinated by TBARS method showed that the tested extracts, as well as wild oregano essential oil possess good in vitro antioxidant activity; while activity measured by OxHLIA method showed high antioxidant potential but only for L. vellereus, R. integra and R. nigricans samples. As for the cytotoxic potential towards tumor cell line NCI – H460 L.",
publisher = "Belgrade: Faculty of Biology, University of Belgrade",
journal = "Faculty of Biology; University of Belgrade",
title = "Hemijski sastav ekstrakata makromiceta i etarskih ulja divljeg origana i korijandera i njihov in vitro potencijal u tretmanu uzročnika hroničnog tonzilitisa, Chemical composition of macromycetes extracts, wild oregano and coriander essential oils and their in vitro potential in the treatment of chronic tonsillitis causative agents",
pages = "1-111",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_4666"
}

Kostić, M.. (2021). Hemijski sastav ekstrakata makromiceta i etarskih ulja divljeg origana i korijandera i njihov in vitro potencijal u tretmanu uzročnika hroničnog tonzilitisa. in Faculty of Biology; University of Belgrade
Belgrade: Faculty of Biology, University of Belgrade., 1-111.
https://hdl.handle.net/21.15107/rcub_ibiss_4666

Kostić M. Hemijski sastav ekstrakata makromiceta i etarskih ulja divljeg origana i korijandera i njihov in vitro potencijal u tretmanu uzročnika hroničnog tonzilitisa. in Faculty of Biology; University of Belgrade. 2021;:1-111.
https://hdl.handle.net/21.15107/rcub_ibiss_4666 .

Kostić, Marina, "Hemijski sastav ekstrakata makromiceta i etarskih ulja divljeg origana i korijandera i njihov in vitro potencijal u tretmanu uzročnika hroničnog tonzilitisa" in Faculty of Biology; University of Belgrade (2021):1-111,
https://hdl.handle.net/21.15107/rcub_ibiss_4666 .

TY  - CONF
AU  - Petrović, Jovana
AU  - Glamočlija, Jasmina
AU  - Ilić-Tomić, Tatjana
AU  - Soković, Marina
AU  - Robajac, Dragana
AU  - Nedić, Olgica
AU  - Pavić, Aleksandar
PY  - 2020
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6535
AB  - Laetiporus sulphureus, an edible mushroom, for centuries has been used in traditional 
European and Asian ethno-medicine. Its therapeutic properties have been attributed to different 
types of biologically active compounds, such as terpenes, polysaccharides, steroids, proteins 
and lectins. Recently, mushroom lectins emerged as very potent macromolecules with 
antiproliferative, cytotoxic, antiviral and immunostimulatory activities. Therefore, we isolated 
lectin from L. sulphureus (LSL) and evaluated its anti-angiogenic and anticancer activity in 
vivo, using the zebrafish model. We found that LSL is not toxic at high doses up to 400-
500 μg/mL, while it effectively inhibited angiogenesis and cancer development at much lower 
doses. Compared to sunitinib-malate, cardiotoxic and myelosupressive anti-angiogenic drug of 
clinical relevance, therapeutic potential of LSL was 378-fold higher. Wound healing and MTT 
assays were employed to examine antimigratory effect and endothelial cytotoxicity. 
Surprisingly, LSL affected human colorectal carcinoma and mouse melanoma cell lines, by 
almost completely diminishing their growth, neovascularization and metastasis. Moreover, in 
comparison to the used control (cisplatin), LSL showed markedly greater activity, while its 
potency turned out to be 8-fold higher towards colorectal carcinoma than melanoma. These 
encouraging data strongly imply that LSL can be considered for the application as supporting 
agent in chemotherapy against colorectal carcinoma and melanoma or used in pharmaceutical 
industry.
PB  - Belgrade: NutRedox, COST Action CA16112
C3  - WGs Meeting of the NutRedOx COST Action CA16112: Nutraceuticals in balancing redox status in ageing and age-related diseases; 2020 Mar 2-3; Belgrade, Serbia
T1  - Laetiporus sulphureus lectin inhibits angiogenesis and tumor development in the zebrafish xenograft models of colorectal carcinoma and melanoma.
SP  - 43
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_6535
ER  - 

@conference{
author = "Petrović, Jovana and Glamočlija, Jasmina and Ilić-Tomić, Tatjana and Soković, Marina and Robajac, Dragana and Nedić, Olgica and Pavić, Aleksandar",
year = "2020",
abstract = "Laetiporus sulphureus, an edible mushroom, for centuries has been used in traditional 
European and Asian ethno-medicine. Its therapeutic properties have been attributed to different 
types of biologically active compounds, such as terpenes, polysaccharides, steroids, proteins 
and lectins. Recently, mushroom lectins emerged as very potent macromolecules with 
antiproliferative, cytotoxic, antiviral and immunostimulatory activities. Therefore, we isolated 
lectin from L. sulphureus (LSL) and evaluated its anti-angiogenic and anticancer activity in 
vivo, using the zebrafish model. We found that LSL is not toxic at high doses up to 400-
500 μg/mL, while it effectively inhibited angiogenesis and cancer development at much lower 
doses. Compared to sunitinib-malate, cardiotoxic and myelosupressive anti-angiogenic drug of 
clinical relevance, therapeutic potential of LSL was 378-fold higher. Wound healing and MTT 
assays were employed to examine antimigratory effect and endothelial cytotoxicity. 
Surprisingly, LSL affected human colorectal carcinoma and mouse melanoma cell lines, by 
almost completely diminishing their growth, neovascularization and metastasis. Moreover, in 
comparison to the used control (cisplatin), LSL showed markedly greater activity, while its 
potency turned out to be 8-fold higher towards colorectal carcinoma than melanoma. These 
encouraging data strongly imply that LSL can be considered for the application as supporting 
agent in chemotherapy against colorectal carcinoma and melanoma or used in pharmaceutical 
industry.",
publisher = "Belgrade: NutRedox, COST Action CA16112",
journal = "WGs Meeting of the NutRedOx COST Action CA16112: Nutraceuticals in balancing redox status in ageing and age-related diseases; 2020 Mar 2-3; Belgrade, Serbia",
title = "Laetiporus sulphureus lectin inhibits angiogenesis and tumor development in the zebrafish xenograft models of colorectal carcinoma and melanoma.",
pages = "43",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_6535"
}

Petrović, J., Glamočlija, J., Ilić-Tomić, T., Soković, M., Robajac, D., Nedić, O.,& Pavić, A.. (2020). Laetiporus sulphureus lectin inhibits angiogenesis and tumor development in the zebrafish xenograft models of colorectal carcinoma and melanoma.. in WGs Meeting of the NutRedOx COST Action CA16112: Nutraceuticals in balancing redox status in ageing and age-related diseases; 2020 Mar 2-3; Belgrade, Serbia
Belgrade: NutRedox, COST Action CA16112., 43.
https://hdl.handle.net/21.15107/rcub_ibiss_6535

Petrović J, Glamočlija J, Ilić-Tomić T, Soković M, Robajac D, Nedić O, Pavić A. Laetiporus sulphureus lectin inhibits angiogenesis and tumor development in the zebrafish xenograft models of colorectal carcinoma and melanoma.. in WGs Meeting of the NutRedOx COST Action CA16112: Nutraceuticals in balancing redox status in ageing and age-related diseases; 2020 Mar 2-3; Belgrade, Serbia. 2020;:43.
https://hdl.handle.net/21.15107/rcub_ibiss_6535 .

Petrović, Jovana, Glamočlija, Jasmina, Ilić-Tomić, Tatjana, Soković, Marina, Robajac, Dragana, Nedić, Olgica, Pavić, Aleksandar, "Laetiporus sulphureus lectin inhibits angiogenesis and tumor development in the zebrafish xenograft models of colorectal carcinoma and melanoma." in WGs Meeting of the NutRedOx COST Action CA16112: Nutraceuticals in balancing redox status in ageing and age-related diseases; 2020 Mar 2-3; Belgrade, Serbia (2020):43,
https://hdl.handle.net/21.15107/rcub_ibiss_6535 .

TY  - JOUR
AU  - Ghada, Bejaoui
AU  - Pereira, Eliana
AU  - Pinela, José
AU  - Prieto, Miguel A.
AU  - Pereira, Carla
AU  - Calhelha, Ricardo C.
AU  - Stojković, Dejan
AU  - Soković, Marina
AU  - Zaghdoudi, Khalil
AU  - Barros, Lillian
AU  - Ferreira, Isabel C. F. R.
PY  - 2020
UR  - https://www.mdpi.com/1420-3049/25/14/3203
UR  - http://www.ncbi.nlm.nih.gov/pubmed/32674320
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3830
AB  - The potential of passion fruit (Passiflora edulis Sims) epicarp to produce anthocyanin-based colorants with bioactive properties was evaluated. First, a five-level three-factor factorial design coupled with response surface methodology was implemented to optimize the extraction of anthocyanins from dark purple epicarps. The extraction yield and cyanidin-3-O-glucoside content were used as response criteria. The constructed models were fitted to the experimental data and used to calculate the optimal processing conditions (t = 38 min, T = 20 °C, S = 0% ethanol/water (v/v) acidified with citric acid to pH 3, and RS/L = 50 g/L) that lead to maximum responses (3.4 mg/g dried epicarp and 9 mg/g extract). Then, the antioxidant, antimicrobial, and cytotoxic activities of anthocyanin extracts obtained using the optimized method and a conventional extraction method were evaluated in vitro. The extract obtained by the optimized method revealed a higher bioactivity, in agreement with the higher cyanidin-3-O-glucoside content. This study highlighted the coloring and bioactive potential of a bio-based ingredient recycled from a bio-waste, which promotes a sustainable bioeconomy in the agri-food sector.
PB  - NLM (Medline)
T2  - Molecules (Basel, Switzerland)
T1  - Recovery of Anthocyanins from Passion Fruit Epicarp for Food Colorants: Extraction Process Optimization and Evaluation of Bioactive Properties.
IS  - 14
VL  - 25
DO  - 10.3390/molecules25143203
SP  - 3203
ER  - 

@article{
author = "Ghada, Bejaoui and Pereira, Eliana and Pinela, José and Prieto, Miguel A. and Pereira, Carla and Calhelha, Ricardo C. and Stojković, Dejan and Soković, Marina and Zaghdoudi, Khalil and Barros, Lillian and Ferreira, Isabel C. F. R.",
year = "2020",
abstract = "The potential of passion fruit (Passiflora edulis Sims) epicarp to produce anthocyanin-based colorants with bioactive properties was evaluated. First, a five-level three-factor factorial design coupled with response surface methodology was implemented to optimize the extraction of anthocyanins from dark purple epicarps. The extraction yield and cyanidin-3-O-glucoside content were used as response criteria. The constructed models were fitted to the experimental data and used to calculate the optimal processing conditions (t = 38 min, T = 20 °C, S = 0% ethanol/water (v/v) acidified with citric acid to pH 3, and RS/L = 50 g/L) that lead to maximum responses (3.4 mg/g dried epicarp and 9 mg/g extract). Then, the antioxidant, antimicrobial, and cytotoxic activities of anthocyanin extracts obtained using the optimized method and a conventional extraction method were evaluated in vitro. The extract obtained by the optimized method revealed a higher bioactivity, in agreement with the higher cyanidin-3-O-glucoside content. This study highlighted the coloring and bioactive potential of a bio-based ingredient recycled from a bio-waste, which promotes a sustainable bioeconomy in the agri-food sector.",
publisher = "NLM (Medline)",
journal = "Molecules (Basel, Switzerland)",
title = "Recovery of Anthocyanins from Passion Fruit Epicarp for Food Colorants: Extraction Process Optimization and Evaluation of Bioactive Properties.",
number = "14",
volume = "25",
doi = "10.3390/molecules25143203",
pages = "3203"
}

Ghada, B., Pereira, E., Pinela, J., Prieto, M. A., Pereira, C., Calhelha, R. C., Stojković, D., Soković, M., Zaghdoudi, K., Barros, L.,& Ferreira, I. C. F. R.. (2020). Recovery of Anthocyanins from Passion Fruit Epicarp for Food Colorants: Extraction Process Optimization and Evaluation of Bioactive Properties.. in Molecules (Basel, Switzerland)
NLM (Medline)., 25(14), 3203.
https://doi.org/10.3390/molecules25143203

Ghada B, Pereira E, Pinela J, Prieto MA, Pereira C, Calhelha RC, Stojković D, Soković M, Zaghdoudi K, Barros L, Ferreira ICFR. Recovery of Anthocyanins from Passion Fruit Epicarp for Food Colorants: Extraction Process Optimization and Evaluation of Bioactive Properties.. in Molecules (Basel, Switzerland). 2020;25(14):3203.
doi:10.3390/molecules25143203 .

Ghada, Bejaoui, Pereira, Eliana, Pinela, José, Prieto, Miguel A., Pereira, Carla, Calhelha, Ricardo C., Stojković, Dejan, Soković, Marina, Zaghdoudi, Khalil, Barros, Lillian, Ferreira, Isabel C. F. R., "Recovery of Anthocyanins from Passion Fruit Epicarp for Food Colorants: Extraction Process Optimization and Evaluation of Bioactive Properties." in Molecules (Basel, Switzerland), 25, no. 14 (2020):3203,
https://doi.org/10.3390/molecules25143203 . .

TY  - JOUR
AU  - Mandim, Filipa
AU  - Petropoulos, Spyridon A.
AU  - Giannoulis, Kyriakos D.
AU  - Dias, Maria Inês
AU  - Fernandes, Ângela
AU  - Pinela, José
AU  - Kostić, Marina
AU  - Soković, Marina
AU  - Barros, Lillian
AU  - Santos-Buelga, Celestino
AU  - Ferreira, Isabel C.F.R.
PY  - 2020
UR  - https://linkinghub.elsevier.com/retrieve/pii/S0963996920303069
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3674
AB  - Cynara cardunculus L. (cardoon) has several health benefits mainly attributed to its abundance in polyphenols. In this study, cardoon heads (capitula) were harvested in Greece during the flowering stage, and the hydroethanolic extracts were assessed in terms of phenolic compounds composition and antioxidant, cytotoxic, anti-inflammatory, and antimicrobial activities. The phenolic profile was evaluated by HPLC-DAD-ESI/MS to better understand the seasonal changes in the individual compound levels and how these changes correlate with bioactive properties. The main phenolic compounds identified were caffeoylquinic and dicaffeoylquinic acid derivatives. Immature heads (Car A: principal growth stage (PGS) 5) had the highest phenolic content (34.3 mg/g) and cytotoxic (GI50 of 69–268 µg/mL) and anti-inflammatory (IC50 of 183 µg/mL) activities. Sample Car D (PGS 6/7) revealed the highest antioxidant (IC50 of 23–227 µg/mL) and antifungal (MIC of 0.26–0.51 mg/mL) potential. Regarding the antibacterial activity, Car E (PGS 7) revealed the best results (MIC of 0.59–1.18 mg/mL). This study suggests that the maturity stage of the plant influences the phenolic composition and bioactivity.
PB  - Elsevier Ltd
T2  - Food Research International
T1  - Seasonal variation of bioactive properties and phenolic composition of Cynara cardunculus var. altilis
VL  - 134
DO  - 10.1016/j.foodres.2020.109281
SP  - 109281
ER  - 

@article{
author = "Mandim, Filipa and Petropoulos, Spyridon A. and Giannoulis, Kyriakos D. and Dias, Maria Inês and Fernandes, Ângela and Pinela, José and Kostić, Marina and Soković, Marina and Barros, Lillian and Santos-Buelga, Celestino and Ferreira, Isabel C.F.R.",
year = "2020",
abstract = "Cynara cardunculus L. (cardoon) has several health benefits mainly attributed to its abundance in polyphenols. In this study, cardoon heads (capitula) were harvested in Greece during the flowering stage, and the hydroethanolic extracts were assessed in terms of phenolic compounds composition and antioxidant, cytotoxic, anti-inflammatory, and antimicrobial activities. The phenolic profile was evaluated by HPLC-DAD-ESI/MS to better understand the seasonal changes in the individual compound levels and how these changes correlate with bioactive properties. The main phenolic compounds identified were caffeoylquinic and dicaffeoylquinic acid derivatives. Immature heads (Car A: principal growth stage (PGS) 5) had the highest phenolic content (34.3 mg/g) and cytotoxic (GI50 of 69–268 µg/mL) and anti-inflammatory (IC50 of 183 µg/mL) activities. Sample Car D (PGS 6/7) revealed the highest antioxidant (IC50 of 23–227 µg/mL) and antifungal (MIC of 0.26–0.51 mg/mL) potential. Regarding the antibacterial activity, Car E (PGS 7) revealed the best results (MIC of 0.59–1.18 mg/mL). This study suggests that the maturity stage of the plant influences the phenolic composition and bioactivity.",
publisher = "Elsevier Ltd",
journal = "Food Research International",
title = "Seasonal variation of bioactive properties and phenolic composition of Cynara cardunculus var. altilis",
volume = "134",
doi = "10.1016/j.foodres.2020.109281",
pages = "109281"
}

Mandim, F., Petropoulos, S. A., Giannoulis, K. D., Dias, M. I., Fernandes, Â., Pinela, J., Kostić, M., Soković, M., Barros, L., Santos-Buelga, C.,& Ferreira, I. C.F.R.. (2020). Seasonal variation of bioactive properties and phenolic composition of Cynara cardunculus var. altilis. in Food Research International
Elsevier Ltd., 134, 109281.
https://doi.org/10.1016/j.foodres.2020.109281

Mandim F, Petropoulos SA, Giannoulis KD, Dias MI, Fernandes Â, Pinela J, Kostić M, Soković M, Barros L, Santos-Buelga C, Ferreira IC. Seasonal variation of bioactive properties and phenolic composition of Cynara cardunculus var. altilis. in Food Research International. 2020;134:109281.
doi:10.1016/j.foodres.2020.109281 .

Mandim, Filipa, Petropoulos, Spyridon A., Giannoulis, Kyriakos D., Dias, Maria Inês, Fernandes, Ângela, Pinela, José, Kostić, Marina, Soković, Marina, Barros, Lillian, Santos-Buelga, Celestino, Ferreira, Isabel C.F.R., "Seasonal variation of bioactive properties and phenolic composition of Cynara cardunculus var. altilis" in Food Research International, 134 (2020):109281,
https://doi.org/10.1016/j.foodres.2020.109281 . .

TY  - JOUR
AU  - Mandim, Filipa
AU  - Dias, Maria Inês
AU  - Pinela, José
AU  - Barracosa, Paulo
AU  - Ivanov, Marija
AU  - Stojković, Dejan
AU  - Soković, Marina
AU  - Santos-Buelga, Celestino
AU  - Barros, Lillian
AU  - Ferreira, Isabel C.F.R.
PY  - 2020
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3659
AB  - Cardoon is a multi-purpose crop for several industries. In this study, cardoon seeds were separated according to the viability and characterized for their chemical composition and bioactivities. Viable seeds contained higher levels of α-tocopherol (6.7 mg/100 g), lipids (23.11 g/100 g, manly oleic and linoleic acids), and free sugars (5.4 g/100 g) than the unviable ones. The hydroethanolic extract of viable seeds presented a higher concentration of phenolic compounds, namely 5-O-caffeoylquinic (8.0 mg/g) and 3,5-O-dicaffeoylquinic (43.9 mg/g) acids, and greater in vitro antioxidant activity. Both extracts showed antibacterial properties, but the best results were achieved with unviable seeds. The extracts had similar antifungal activity but did not reveal anti-inflammatory capacity or cytotoxicity to the tested cell lines. Therefore, while viable seeds contained antioxidant phytochemicals and an energy and carbon source for germination, unavailable seeds stood out for their potential to be used in the development of bio-based antibacterial ingredients.
PB  - Elsevier Ltd
T2  - Food Chemistry
T1  - Chemical composition and in vitro biological activities of cardoon (Cynara cardunculus L. var. altilis DC.) seeds as influenced by viability: Chemical prospection and bioactivity of cardoon seeds
VL  - 323
DO  - 10.1016/j.foodchem.2020.126838
SP  - 126838
ER  - 

@article{
author = "Mandim, Filipa and Dias, Maria Inês and Pinela, José and Barracosa, Paulo and Ivanov, Marija and Stojković, Dejan and Soković, Marina and Santos-Buelga, Celestino and Barros, Lillian and Ferreira, Isabel C.F.R.",
year = "2020",
abstract = "Cardoon is a multi-purpose crop for several industries. In this study, cardoon seeds were separated according to the viability and characterized for their chemical composition and bioactivities. Viable seeds contained higher levels of α-tocopherol (6.7 mg/100 g), lipids (23.11 g/100 g, manly oleic and linoleic acids), and free sugars (5.4 g/100 g) than the unviable ones. The hydroethanolic extract of viable seeds presented a higher concentration of phenolic compounds, namely 5-O-caffeoylquinic (8.0 mg/g) and 3,5-O-dicaffeoylquinic (43.9 mg/g) acids, and greater in vitro antioxidant activity. Both extracts showed antibacterial properties, but the best results were achieved with unviable seeds. The extracts had similar antifungal activity but did not reveal anti-inflammatory capacity or cytotoxicity to the tested cell lines. Therefore, while viable seeds contained antioxidant phytochemicals and an energy and carbon source for germination, unavailable seeds stood out for their potential to be used in the development of bio-based antibacterial ingredients.",
publisher = "Elsevier Ltd",
journal = "Food Chemistry",
title = "Chemical composition and in vitro biological activities of cardoon (Cynara cardunculus L. var. altilis DC.) seeds as influenced by viability: Chemical prospection and bioactivity of cardoon seeds",
volume = "323",
doi = "10.1016/j.foodchem.2020.126838",
pages = "126838"
}

Mandim, F., Dias, M. I., Pinela, J., Barracosa, P., Ivanov, M., Stojković, D., Soković, M., Santos-Buelga, C., Barros, L.,& Ferreira, I. C.F.R.. (2020). Chemical composition and in vitro biological activities of cardoon (Cynara cardunculus L. var. altilis DC.) seeds as influenced by viability: Chemical prospection and bioactivity of cardoon seeds. in Food Chemistry
Elsevier Ltd., 323, 126838.
https://doi.org/10.1016/j.foodchem.2020.126838

Mandim F, Dias MI, Pinela J, Barracosa P, Ivanov M, Stojković D, Soković M, Santos-Buelga C, Barros L, Ferreira IC. Chemical composition and in vitro biological activities of cardoon (Cynara cardunculus L. var. altilis DC.) seeds as influenced by viability: Chemical prospection and bioactivity of cardoon seeds. in Food Chemistry. 2020;323:126838.
doi:10.1016/j.foodchem.2020.126838 .

Mandim, Filipa, Dias, Maria Inês, Pinela, José, Barracosa, Paulo, Ivanov, Marija, Stojković, Dejan, Soković, Marina, Santos-Buelga, Celestino, Barros, Lillian, Ferreira, Isabel C.F.R., "Chemical composition and in vitro biological activities of cardoon (Cynara cardunculus L. var. altilis DC.) seeds as influenced by viability: Chemical prospection and bioactivity of cardoon seeds" in Food Chemistry, 323 (2020):126838,
https://doi.org/10.1016/j.foodchem.2020.126838 . .

TY  - JOUR
AU  - Veličković, Ivona
AU  - Žižak, Željko
AU  - Rajčević, Nemanja
AU  - Ivanov, Marija
AU  - Soković, Marina
AU  - Marin, Petar
AU  - Grujić, Slavica
PY  - 2020
UR  - http://www.serbiosoc.org.rs/arch/index.php/abs/article/view/4932
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3652
AB  - We investigated the total phenolic and flavonoid contents and the anthocyanin profiles in aqueous, ethanol and acetone extracts of Prunus spinosa (Rosaceae) fruit, and their antioxidant, antibacterial, antifungal, antidiabetic and antitumor properties. The contribution of polyphenol contents to the bioactivity of the extracts was calculated and observed through Pearson’s coefficient of correlation. The acetone extract was the richest in phenols and anthocyanins and the ethanol extract in flavonoids. Cyanidin was the most abundant anthocyanin compound in all examined extracts. The ethanol extract showed the most promising antioxidant activity in DPPH, ABTS and FRAP assays. Tested bacteria were more affected by the ethanol than by the aqueous extract. Both the ethanol and aqueous extracts exhibited potential antidiabetic effects, observed as inhibition of α-amylase and α-glucosidase, enzymes linked with diabetes mellitus type II. The ethanol extract was a potent α-glucosidase-inhibitor with a significantly lower IC50 value than the positive control, glucobay, used to treat diabetes mellitus type II. Neither the ethanol nor the aqueous extracts had any effects on tested human malignant cell lines. Our results indicate that the ethanol extract showed the most pronounced in vitro antioxidant and antimicrobial effects, and a potential antidiabetic activity, which can be ascribed to its high flavonoid content. Our results indicate that research of compounds, particularly of flavonoids present in the ethanol extract and their anti-diabetic properties should be examined further.
T2  - Archives of Biological Sciences
T1  - Examination of the polyphenol content and bioactivities of Prunus spinosa L. fruit extracts
IS  - 1
VL  - 72
DO  - 10.2298/abs191217004v
SP  - 105
EP  - 115
ER  - 

@article{
author = "Veličković, Ivona and Žižak, Željko and Rajčević, Nemanja and Ivanov, Marija and Soković, Marina and Marin, Petar and Grujić, Slavica",
year = "2020",
abstract = "We investigated the total phenolic and flavonoid contents and the anthocyanin profiles in aqueous, ethanol and acetone extracts of Prunus spinosa (Rosaceae) fruit, and their antioxidant, antibacterial, antifungal, antidiabetic and antitumor properties. The contribution of polyphenol contents to the bioactivity of the extracts was calculated and observed through Pearson’s coefficient of correlation. The acetone extract was the richest in phenols and anthocyanins and the ethanol extract in flavonoids. Cyanidin was the most abundant anthocyanin compound in all examined extracts. The ethanol extract showed the most promising antioxidant activity in DPPH, ABTS and FRAP assays. Tested bacteria were more affected by the ethanol than by the aqueous extract. Both the ethanol and aqueous extracts exhibited potential antidiabetic effects, observed as inhibition of α-amylase and α-glucosidase, enzymes linked with diabetes mellitus type II. The ethanol extract was a potent α-glucosidase-inhibitor with a significantly lower IC50 value than the positive control, glucobay, used to treat diabetes mellitus type II. Neither the ethanol nor the aqueous extracts had any effects on tested human malignant cell lines. Our results indicate that the ethanol extract showed the most pronounced in vitro antioxidant and antimicrobial effects, and a potential antidiabetic activity, which can be ascribed to its high flavonoid content. Our results indicate that research of compounds, particularly of flavonoids present in the ethanol extract and their anti-diabetic properties should be examined further.",
journal = "Archives of Biological Sciences",
title = "Examination of the polyphenol content and bioactivities of Prunus spinosa L. fruit extracts",
number = "1",
volume = "72",
doi = "10.2298/abs191217004v",
pages = "105-115"
}

Veličković, I., Žižak, Ž., Rajčević, N., Ivanov, M., Soković, M., Marin, P.,& Grujić, S.. (2020). Examination of the polyphenol content and bioactivities of Prunus spinosa L. fruit extracts. in Archives of Biological Sciences, 72(1), 105-115.
https://doi.org/10.2298/abs191217004v

Veličković I, Žižak Ž, Rajčević N, Ivanov M, Soković M, Marin P, Grujić S. Examination of the polyphenol content and bioactivities of Prunus spinosa L. fruit extracts. in Archives of Biological Sciences. 2020;72(1):105-115.
doi:10.2298/abs191217004v .

Veličković, Ivona, Žižak, Željko, Rajčević, Nemanja, Ivanov, Marija, Soković, Marina, Marin, Petar, Grujić, Slavica, "Examination of the polyphenol content and bioactivities of Prunus spinosa L. fruit extracts" in Archives of Biological Sciences, 72, no. 1 (2020):105-115,
https://doi.org/10.2298/abs191217004v . .

TY  - JOUR
AU  - Petrović, Jovana
AU  - Glamočlija, Jasmina
AU  - Ilić-Tomić, Tatjana
AU  - Soković, Marina
AU  - Robajac, Dragana
AU  - Nedić, Olgica
AU  - Pavić, Aleksandar
PY  - 2020
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3603
AB  - In spite of extensive usage of Laetiporus sulphureus (sulphur polypore) in traditional European and Asian ethno-medicine for centuries, its anticancer therapeutic potential and toxicity profile remained explored in animal models. Herein, using zebrafish (Danio rerio), as a preclinical animal model, we demonstrated that L. sulphureus lectin (LSL) and ethanol extract (LSE) are non-toxic at high doses up to 400-500 μg/mL, while they effectively inhibited angiogenesis and cancer development at much lower doses. Lectin showed 74-fold higher anti-angiogenic potency than the extract, and even 378-fold higher therapeutic potential than sunitinib-malate, cardiotoxic and myelosupressive anti-angiogenic drug of clinical relevance. Using wound healing and MTT assays, we proved LSL's strong antimigratory effect and selective endothelial cytotoxicity in relation to lung fibroblasts. In addition, employing the zebrafish xenograft models, we demonstrated that LSL almost completely reduced growth, neovascularization and metastasis of human colorectal carcinoma and mouse melanoma. Even more, LSL exerted 8-fold higher potency towards colorectal carcinoma than melanoma, showing markedly higher activity than cisplatin, while LSE failed to express any anticancer activity. Accompanied with non-toxic response, including neutropenia and inflammation, the results of this study strongly imply that LSL could be used as safe adjuvant in chemotherapy against colorectal carcinoma and melanoma.
T2  - International Journal of Biological Macromolecules
T1  - Lectin from Laetiporus sulphureus effectively inhibits angiogenesis and tumor development in the zebrafish xenograft models of colorectal carcinoma and melanoma.
VL  - 148
DO  - 10.1016/j.ijbiomac.2020.01.033
SP  - 129
EP  - 139
ER  - 

@article{
author = "Petrović, Jovana and Glamočlija, Jasmina and Ilić-Tomić, Tatjana and Soković, Marina and Robajac, Dragana and Nedić, Olgica and Pavić, Aleksandar",
year = "2020",
abstract = "In spite of extensive usage of Laetiporus sulphureus (sulphur polypore) in traditional European and Asian ethno-medicine for centuries, its anticancer therapeutic potential and toxicity profile remained explored in animal models. Herein, using zebrafish (Danio rerio), as a preclinical animal model, we demonstrated that L. sulphureus lectin (LSL) and ethanol extract (LSE) are non-toxic at high doses up to 400-500 μg/mL, while they effectively inhibited angiogenesis and cancer development at much lower doses. Lectin showed 74-fold higher anti-angiogenic potency than the extract, and even 378-fold higher therapeutic potential than sunitinib-malate, cardiotoxic and myelosupressive anti-angiogenic drug of clinical relevance. Using wound healing and MTT assays, we proved LSL's strong antimigratory effect and selective endothelial cytotoxicity in relation to lung fibroblasts. In addition, employing the zebrafish xenograft models, we demonstrated that LSL almost completely reduced growth, neovascularization and metastasis of human colorectal carcinoma and mouse melanoma. Even more, LSL exerted 8-fold higher potency towards colorectal carcinoma than melanoma, showing markedly higher activity than cisplatin, while LSE failed to express any anticancer activity. Accompanied with non-toxic response, including neutropenia and inflammation, the results of this study strongly imply that LSL could be used as safe adjuvant in chemotherapy against colorectal carcinoma and melanoma.",
journal = "International Journal of Biological Macromolecules",
title = "Lectin from Laetiporus sulphureus effectively inhibits angiogenesis and tumor development in the zebrafish xenograft models of colorectal carcinoma and melanoma.",
volume = "148",
doi = "10.1016/j.ijbiomac.2020.01.033",
pages = "129-139"
}

Petrović, J., Glamočlija, J., Ilić-Tomić, T., Soković, M., Robajac, D., Nedić, O.,& Pavić, A.. (2020). Lectin from Laetiporus sulphureus effectively inhibits angiogenesis and tumor development in the zebrafish xenograft models of colorectal carcinoma and melanoma.. in International Journal of Biological Macromolecules, 148, 129-139.
https://doi.org/10.1016/j.ijbiomac.2020.01.033

Petrović J, Glamočlija J, Ilić-Tomić T, Soković M, Robajac D, Nedić O, Pavić A. Lectin from Laetiporus sulphureus effectively inhibits angiogenesis and tumor development in the zebrafish xenograft models of colorectal carcinoma and melanoma.. in International Journal of Biological Macromolecules. 2020;148:129-139.
doi:10.1016/j.ijbiomac.2020.01.033 .

Petrović, Jovana, Glamočlija, Jasmina, Ilić-Tomić, Tatjana, Soković, Marina, Robajac, Dragana, Nedić, Olgica, Pavić, Aleksandar, "Lectin from Laetiporus sulphureus effectively inhibits angiogenesis and tumor development in the zebrafish xenograft models of colorectal carcinoma and melanoma." in International Journal of Biological Macromolecules, 148 (2020):129-139,
https://doi.org/10.1016/j.ijbiomac.2020.01.033 . .

TY  - JOUR
AU  - Dias, Murilo
AU  - Caleja, Cristina
AU  - Pereira, Carla
AU  - Calhelha, Ricardo C.
AU  - Kostić, Marina
AU  - Soković, Marina
AU  - Tavares, Débora
AU  - Baraldi, Ilton José
AU  - Barros, Lillian
AU  - Ferreira, Isabel C.F.R.
PY  - 2020
UR  - https://www.sciencedirect.com/science/article/pii/S0963996919306398?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3524
AB  - Kiwis are an example of fruits with excellent bioactive properties worldwide appreciated and consumed generating tons of waste. Thus, the objective of this work was to compare two varieties of kiwi: Actinidia deliciosa cv. “Hayward” (green) and Actinidia spp. (red) regarding the nutritional value of their pulps, chemical composition and bioactivities of each pulp and peel. The results revealed that pulps have a high water content and low amount of other macronutrients. Both parts of red kiwi presented the highest tocopherols content and red kiwi pulp presented the highest content in ascorbic acid. In general, the peels exhibited the highest antioxidant activity and green kiwi peels showed cytotoxicity and anti-inflammatory activity, which could be related to its higher content in phenolic compounds, especially B-type (epi)catechin dimer. Therefore, kiwi components currently underutilized may be indicated as a source of natural functionalizing ingredients with several benefits for human health.
T2  - Food Research International
T1  - Chemical composition and bioactive properties of byproducts from two different kiwi varieties
VL  - 127
DO  - 10.1016/J.FOODRES.2019.108753
SP  - 108753
ER  - 

@article{
author = "Dias, Murilo and Caleja, Cristina and Pereira, Carla and Calhelha, Ricardo C. and Kostić, Marina and Soković, Marina and Tavares, Débora and Baraldi, Ilton José and Barros, Lillian and Ferreira, Isabel C.F.R.",
year = "2020",
abstract = "Kiwis are an example of fruits with excellent bioactive properties worldwide appreciated and consumed generating tons of waste. Thus, the objective of this work was to compare two varieties of kiwi: Actinidia deliciosa cv. “Hayward” (green) and Actinidia spp. (red) regarding the nutritional value of their pulps, chemical composition and bioactivities of each pulp and peel. The results revealed that pulps have a high water content and low amount of other macronutrients. Both parts of red kiwi presented the highest tocopherols content and red kiwi pulp presented the highest content in ascorbic acid. In general, the peels exhibited the highest antioxidant activity and green kiwi peels showed cytotoxicity and anti-inflammatory activity, which could be related to its higher content in phenolic compounds, especially B-type (epi)catechin dimer. Therefore, kiwi components currently underutilized may be indicated as a source of natural functionalizing ingredients with several benefits for human health.",
journal = "Food Research International",
title = "Chemical composition and bioactive properties of byproducts from two different kiwi varieties",
volume = "127",
doi = "10.1016/J.FOODRES.2019.108753",
pages = "108753"
}

Dias, M., Caleja, C., Pereira, C., Calhelha, R. C., Kostić, M., Soković, M., Tavares, D., Baraldi, I. J., Barros, L.,& Ferreira, I. C.F.R.. (2020). Chemical composition and bioactive properties of byproducts from two different kiwi varieties. in Food Research International, 127, 108753.
https://doi.org/10.1016/J.FOODRES.2019.108753

Dias M, Caleja C, Pereira C, Calhelha RC, Kostić M, Soković M, Tavares D, Baraldi IJ, Barros L, Ferreira IC. Chemical composition and bioactive properties of byproducts from two different kiwi varieties. in Food Research International. 2020;127:108753.
doi:10.1016/J.FOODRES.2019.108753 .

Dias, Murilo, Caleja, Cristina, Pereira, Carla, Calhelha, Ricardo C., Kostić, Marina, Soković, Marina, Tavares, Débora, Baraldi, Ilton José, Barros, Lillian, Ferreira, Isabel C.F.R., "Chemical composition and bioactive properties of byproducts from two different kiwi varieties" in Food Research International, 127 (2020):108753,
https://doi.org/10.1016/J.FOODRES.2019.108753 . .

TY  - JOUR
AU  - Stojković, Dejan
AU  - Kostić, Marina
AU  - Ivanov, Marija
AU  - Aleksić, Milena
AU  - Vasiljević, Perica
AU  - Nikolić, Miloš
AU  - Soković, Marina
PY  - 2020
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4059
AB  - The following review is oriented towards microbes linked to Alzheimer’s disease (AD) and antimicrobial effect of compounds and extracts derived from aquatic organisms against specific bacteria, fungi and viruses which were found previously in patients suffering from AD. Major group of microbes linked to AD include bacteria: Chlamydia pneumoniae, Helicobacter pylori, Porphyromonas gingivalis, Fusobacterium nucleatum, Prevotella intermedia, Actinomyces naeslundii, spirochete group; fungi: Candida sp., Cryptococcus sp., Saccharomyces sp., Malassezia sp., Botrytis sp., and viruses: herpes simplex virus type 1 (HSV-1), Human cytomegalovirus (CMV), hepatitis C virus (HCV). In the light of that fact, this review is the first to link antimicrobial potential of aquatic organisms against these sorts of microbes. This literature review might serve as a starting platform to develop novel supportive therapy for patients suffering from AD and to possibly prevent escalation of the disease in patients already having high-risk factors for AD occurrence.
PB  - Bentham Science Publishers
T2  - Current Medicinal Chemistry
T1  - Linking Antimicrobial Potential of Natural Products Derived from Aquatic Organisms and Microbes Involved in Alzheimer's Disease - A Review
IS  - 26
VL  - 27
DO  - 10.2174/0929867325666180309103645
SP  - 4372
EP  - 4391
ER  - 

@article{
author = "Stojković, Dejan and Kostić, Marina and Ivanov, Marija and Aleksić, Milena and Vasiljević, Perica and Nikolić, Miloš and Soković, Marina",
year = "2020",
abstract = "The following review is oriented towards microbes linked to Alzheimer’s disease (AD) and antimicrobial effect of compounds and extracts derived from aquatic organisms against specific bacteria, fungi and viruses which were found previously in patients suffering from AD. Major group of microbes linked to AD include bacteria: Chlamydia pneumoniae, Helicobacter pylori, Porphyromonas gingivalis, Fusobacterium nucleatum, Prevotella intermedia, Actinomyces naeslundii, spirochete group; fungi: Candida sp., Cryptococcus sp., Saccharomyces sp., Malassezia sp., Botrytis sp., and viruses: herpes simplex virus type 1 (HSV-1), Human cytomegalovirus (CMV), hepatitis C virus (HCV). In the light of that fact, this review is the first to link antimicrobial potential of aquatic organisms against these sorts of microbes. This literature review might serve as a starting platform to develop novel supportive therapy for patients suffering from AD and to possibly prevent escalation of the disease in patients already having high-risk factors for AD occurrence.",
publisher = "Bentham Science Publishers",
journal = "Current Medicinal Chemistry",
title = "Linking Antimicrobial Potential of Natural Products Derived from Aquatic Organisms and Microbes Involved in Alzheimer's Disease - A Review",
number = "26",
volume = "27",
doi = "10.2174/0929867325666180309103645",
pages = "4372-4391"
}

Stojković, D., Kostić, M., Ivanov, M., Aleksić, M., Vasiljević, P., Nikolić, M.,& Soković, M.. (2020). Linking Antimicrobial Potential of Natural Products Derived from Aquatic Organisms and Microbes Involved in Alzheimer's Disease - A Review. in Current Medicinal Chemistry
Bentham Science Publishers., 27(26), 4372-4391.
https://doi.org/10.2174/0929867325666180309103645

Stojković D, Kostić M, Ivanov M, Aleksić M, Vasiljević P, Nikolić M, Soković M. Linking Antimicrobial Potential of Natural Products Derived from Aquatic Organisms and Microbes Involved in Alzheimer's Disease - A Review. in Current Medicinal Chemistry. 2020;27(26):4372-4391.
doi:10.2174/0929867325666180309103645 .

Stojković, Dejan, Kostić, Marina, Ivanov, Marija, Aleksić, Milena, Vasiljević, Perica, Nikolić, Miloš, Soković, Marina, "Linking Antimicrobial Potential of Natural Products Derived from Aquatic Organisms and Microbes Involved in Alzheimer's Disease - A Review" in Current Medicinal Chemistry, 27, no. 26 (2020):4372-4391,
https://doi.org/10.2174/0929867325666180309103645 . .

TY  - JOUR
AU  - Kostić, Marina
AU  - Ivanov, Marija
AU  - Sanković Babić, Snežana
AU  - Petrović, Jovana
AU  - Soković, Marina
AU  - Ćirić, Ana
PY  - 2020
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4061
AB  - Upper respiratory tract infections include inflammations of the nose, sinuses (sinusitis), pharynx (tonsillitis, pharyngitis) and larynx (laryngitis) with bacteria or viruses as the main cause of these conditions. Due to their repetitive nature, chronic respiratory infections represent a global problem which is often a result of improper treatment. If not treated adequately, these conditions may have serious consequences. On the other hand, mis - and overuse of antibiotics has reduced their efficiency and accelerated the development of resistant bacterial strains, which further complicates the treatment of infections. This literature review will focus on current knowledge regarding medicinal plants and mushrooms which have been traditionally used in the treatment of infections caused by chronic sinusitis and tonsillitis commonly linked to bacteria - Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Fusobacterium nucleatum, Haemophilus influenzae and Moraxella catarrhalis. The present literature overview might be considered as a starting point for the development of novel, natural antimicrobial products with potential practical use in the treatment of chronic tonsillitis and sinusitis.
PB  - Bentham Science Publishers
T2  - Current Medicinal Chemistry
T1  - An Up-to-Date Review on Bio-Resource Therapeutics Effective against Bacterial Species Frequently Associated with Chronic Sinusitis and Tonsillitis
IS  - 41
VL  - 27
DO  - 10.2174/0929867327666200505093143
SP  - 6892
EP  - 6909
ER  - 

@article{
author = "Kostić, Marina and Ivanov, Marija and Sanković Babić, Snežana and Petrović, Jovana and Soković, Marina and Ćirić, Ana",
year = "2020",
abstract = "Upper respiratory tract infections include inflammations of the nose, sinuses (sinusitis), pharynx (tonsillitis, pharyngitis) and larynx (laryngitis) with bacteria or viruses as the main cause of these conditions. Due to their repetitive nature, chronic respiratory infections represent a global problem which is often a result of improper treatment. If not treated adequately, these conditions may have serious consequences. On the other hand, mis - and overuse of antibiotics has reduced their efficiency and accelerated the development of resistant bacterial strains, which further complicates the treatment of infections. This literature review will focus on current knowledge regarding medicinal plants and mushrooms which have been traditionally used in the treatment of infections caused by chronic sinusitis and tonsillitis commonly linked to bacteria - Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Fusobacterium nucleatum, Haemophilus influenzae and Moraxella catarrhalis. The present literature overview might be considered as a starting point for the development of novel, natural antimicrobial products with potential practical use in the treatment of chronic tonsillitis and sinusitis.",
publisher = "Bentham Science Publishers",
journal = "Current Medicinal Chemistry",
title = "An Up-to-Date Review on Bio-Resource Therapeutics Effective against Bacterial Species Frequently Associated with Chronic Sinusitis and Tonsillitis",
number = "41",
volume = "27",
doi = "10.2174/0929867327666200505093143",
pages = "6892-6909"
}

Kostić, M., Ivanov, M., Sanković Babić, S., Petrović, J., Soković, M.,& Ćirić, A.. (2020). An Up-to-Date Review on Bio-Resource Therapeutics Effective against Bacterial Species Frequently Associated with Chronic Sinusitis and Tonsillitis. in Current Medicinal Chemistry
Bentham Science Publishers., 27(41), 6892-6909.
https://doi.org/10.2174/0929867327666200505093143

Kostić M, Ivanov M, Sanković Babić S, Petrović J, Soković M, Ćirić A. An Up-to-Date Review on Bio-Resource Therapeutics Effective against Bacterial Species Frequently Associated with Chronic Sinusitis and Tonsillitis. in Current Medicinal Chemistry. 2020;27(41):6892-6909.
doi:10.2174/0929867327666200505093143 .

Kostić, Marina, Ivanov, Marija, Sanković Babić, Snežana, Petrović, Jovana, Soković, Marina, Ćirić, Ana, "An Up-to-Date Review on Bio-Resource Therapeutics Effective against Bacterial Species Frequently Associated with Chronic Sinusitis and Tonsillitis" in Current Medicinal Chemistry, 27, no. 41 (2020):6892-6909,
https://doi.org/10.2174/0929867327666200505093143 . .

TY  - JOUR
AU  - Cvetić Antić, Tijana
AU  - Janošević, Dušica
AU  - Maksimović, Vuk M.
AU  - Živić, Miroslav
AU  - Budimir, Snežana
AU  - Glamočlija, Jasmina
AU  - Mitrović, Aleksandra Lj
PY  - 2020
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3730
AB  - We present changes in Tacitus bellus antioxidative system that specifically correspond to subsequent phases of hemibiotroph Fusarium verticillioides infection revealed by histological analysis. T. bellus response to spore germination 6 h post inoculation (hpi), manifested as first oxidative burst, was characterized by transient decrease in malondialdehyde (MDA) content, transient increase in catalase (CAT), low level of superoxide dismutase (SOD) and peroxidase (POD) activity, as well as with transient decrease in total antioxidant capacity (TAC), total phenol content (TPC) and phenylalanine ammonium lyase activity (PAL), and no changes in polyphenol oxidase (PPO) activity, or phenolic profile. During the biotrophic phase of F. verticillioides infection, characterized by hyphae spread intercellularly in epidermal and mesophyll tissue, the host antioxidative system was suppressed. The transition to necrotrophic phase of F. verticillioides infection (inter- and intracellular colonization and sporulation), occurred 3-4 days post inoculation (dpi). During the necrotrophic phase, 5-7 dpi, slowed progression of colonization of T. bellus mesophyll cells occurred and it coincided with sharp increase in MDA content and CAT, SOD and POD activities, but the drop in TAC, TPC content, and PPO activity, as well as the production of phytotoxin fusaric acid. Presented results add to the knowledge of events and mechanisms related to the transition from biotrophy to necrotrophy in F. verticillioides.
PB  - NLM (Medline)
T2  - Journal of Plant Physiology
T1  - Biochemical and histological characterization of succulent plant Tacitus bellus response to Fusarium verticillioides infection in vitro
VL  - 244
DO  - 10.1016/j.jplph.2019.153086
SP  - 153086
ER  - 

@article{
author = "Cvetić Antić, Tijana and Janošević, Dušica and Maksimović, Vuk M. and Živić, Miroslav and Budimir, Snežana and Glamočlija, Jasmina and Mitrović, Aleksandra Lj",
year = "2020",
abstract = "We present changes in Tacitus bellus antioxidative system that specifically correspond to subsequent phases of hemibiotroph Fusarium verticillioides infection revealed by histological analysis. T. bellus response to spore germination 6 h post inoculation (hpi), manifested as first oxidative burst, was characterized by transient decrease in malondialdehyde (MDA) content, transient increase in catalase (CAT), low level of superoxide dismutase (SOD) and peroxidase (POD) activity, as well as with transient decrease in total antioxidant capacity (TAC), total phenol content (TPC) and phenylalanine ammonium lyase activity (PAL), and no changes in polyphenol oxidase (PPO) activity, or phenolic profile. During the biotrophic phase of F. verticillioides infection, characterized by hyphae spread intercellularly in epidermal and mesophyll tissue, the host antioxidative system was suppressed. The transition to necrotrophic phase of F. verticillioides infection (inter- and intracellular colonization and sporulation), occurred 3-4 days post inoculation (dpi). During the necrotrophic phase, 5-7 dpi, slowed progression of colonization of T. bellus mesophyll cells occurred and it coincided with sharp increase in MDA content and CAT, SOD and POD activities, but the drop in TAC, TPC content, and PPO activity, as well as the production of phytotoxin fusaric acid. Presented results add to the knowledge of events and mechanisms related to the transition from biotrophy to necrotrophy in F. verticillioides.",
publisher = "NLM (Medline)",
journal = "Journal of Plant Physiology",
title = "Biochemical and histological characterization of succulent plant Tacitus bellus response to Fusarium verticillioides infection in vitro",
volume = "244",
doi = "10.1016/j.jplph.2019.153086",
pages = "153086"
}

Cvetić Antić, T., Janošević, D., Maksimović, V. M., Živić, M., Budimir, S., Glamočlija, J.,& Mitrović, A. L.. (2020). Biochemical and histological characterization of succulent plant Tacitus bellus response to Fusarium verticillioides infection in vitro. in Journal of Plant Physiology
NLM (Medline)., 244, 153086.
https://doi.org/10.1016/j.jplph.2019.153086

Cvetić Antić T, Janošević D, Maksimović VM, Živić M, Budimir S, Glamočlija J, Mitrović AL. Biochemical and histological characterization of succulent plant Tacitus bellus response to Fusarium verticillioides infection in vitro. in Journal of Plant Physiology. 2020;244:153086.
doi:10.1016/j.jplph.2019.153086 .

Cvetić Antić, Tijana, Janošević, Dušica, Maksimović, Vuk M., Živić, Miroslav, Budimir, Snežana, Glamočlija, Jasmina, Mitrović, Aleksandra Lj, "Biochemical and histological characterization of succulent plant Tacitus bellus response to Fusarium verticillioides infection in vitro" in Journal of Plant Physiology, 244 (2020):153086,
https://doi.org/10.1016/j.jplph.2019.153086 . .

TY  - CONF
AU  - Drakulić, Danijela
AU  - Stojković, Dejan
AU  - Soković, Marina
AU  - Stevanović, Milena
PY  - 2019
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4370
AB  - Cancer represents a heterogeneous group of diseases characterized by uncontrolled 
proliferation of cells, tissue invasion and metastasis. Despite current therapeutic 
strategies which include a combination of surgery, radiation and chemotherapy, cancer 
is second leading cause of death worldwide next to cardiovascular diseases. Therefore, 
the identification of new drugs with high sensitivity to cancer cells is warranted. The 
anticancer properties of plants and their compounds have been shown since ancient 
times and nowadays, there is a growing interest for identification of new plant-derived 
anticancer agents. 
This study was designed to analyze antiproliferative potential of three different plant 
species, namely Ononis spinosa L. (Fabaceae), Anthriscus cerefolium (L.) Hoffm. (Apiaceae) 
and Phlomis fruticosa L. (Lamiaceae). The aerial parts of plants were collected, dried 
and the plant material was subjected to successive extraction with methanol and 
then evaporated to dryness on a rotary vacuum evaporator. The obtained methanolic 
extracts were used for further analysis. Cytotoxic effect of methanolic extracts on HaCaT 
(spontaneously immortalized human keratinocyte cell line), MCF-7 (breast cancer cell 
line), SiHa (cervical cancer cell line), A172 (glioblastoma cell line) and HepG2 (human 
hepatocellular carcinoma cell line) cells was determined by crystal violet colorimetric 
assay. Antiproliferative activity of methanolic extracts on glioblastoma cells was 
evaluated by Ki67 immunostaining.
The results showed that plant extracts reduced viability of all tested cell lines. The 
most active extract was the one from O. spinosa, indicating by the lowest IC50 value. 
Ki67 immunostaining indicates antiproliferative activity of methanolic extracts on 
glioblastoma cells.
PB  - Belgrade: Institute for Biological Research "Siniša Stanković", University of Belgrade
C3  - The 2nd Balkans-China Mini-symposium on Natural Products and Drug Discovery; 2019 Apr 11-13; Belgrade, Serbia
T1  - Comparative study of antiproliferative potential of three  different plant species
SP  - 38
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_4370
ER  - 

@conference{
author = "Drakulić, Danijela and Stojković, Dejan and Soković, Marina and Stevanović, Milena",
year = "2019",
abstract = "Cancer represents a heterogeneous group of diseases characterized by uncontrolled 
proliferation of cells, tissue invasion and metastasis. Despite current therapeutic 
strategies which include a combination of surgery, radiation and chemotherapy, cancer 
is second leading cause of death worldwide next to cardiovascular diseases. Therefore, 
the identification of new drugs with high sensitivity to cancer cells is warranted. The 
anticancer properties of plants and their compounds have been shown since ancient 
times and nowadays, there is a growing interest for identification of new plant-derived 
anticancer agents. 
This study was designed to analyze antiproliferative potential of three different plant 
species, namely Ononis spinosa L. (Fabaceae), Anthriscus cerefolium (L.) Hoffm. (Apiaceae) 
and Phlomis fruticosa L. (Lamiaceae). The aerial parts of plants were collected, dried 
and the plant material was subjected to successive extraction with methanol and 
then evaporated to dryness on a rotary vacuum evaporator. The obtained methanolic 
extracts were used for further analysis. Cytotoxic effect of methanolic extracts on HaCaT 
(spontaneously immortalized human keratinocyte cell line), MCF-7 (breast cancer cell 
line), SiHa (cervical cancer cell line), A172 (glioblastoma cell line) and HepG2 (human 
hepatocellular carcinoma cell line) cells was determined by crystal violet colorimetric 
assay. Antiproliferative activity of methanolic extracts on glioblastoma cells was 
evaluated by Ki67 immunostaining.
The results showed that plant extracts reduced viability of all tested cell lines. The 
most active extract was the one from O. spinosa, indicating by the lowest IC50 value. 
Ki67 immunostaining indicates antiproliferative activity of methanolic extracts on 
glioblastoma cells.",
publisher = "Belgrade: Institute for Biological Research "Siniša Stanković", University of Belgrade",
journal = "The 2nd Balkans-China Mini-symposium on Natural Products and Drug Discovery; 2019 Apr 11-13; Belgrade, Serbia",
title = "Comparative study of antiproliferative potential of three  different plant species",
pages = "38",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_4370"
}

Drakulić, D., Stojković, D., Soković, M.,& Stevanović, M.. (2019). Comparative study of antiproliferative potential of three  different plant species. in The 2nd Balkans-China Mini-symposium on Natural Products and Drug Discovery; 2019 Apr 11-13; Belgrade, Serbia
Belgrade: Institute for Biological Research "Siniša Stanković", University of Belgrade., 38.
https://hdl.handle.net/21.15107/rcub_ibiss_4370

Drakulić D, Stojković D, Soković M, Stevanović M. Comparative study of antiproliferative potential of three  different plant species. in The 2nd Balkans-China Mini-symposium on Natural Products and Drug Discovery; 2019 Apr 11-13; Belgrade, Serbia. 2019;:38.
https://hdl.handle.net/21.15107/rcub_ibiss_4370 .

Drakulić, Danijela, Stojković, Dejan, Soković, Marina, Stevanović, Milena, "Comparative study of antiproliferative potential of three  different plant species" in The 2nd Balkans-China Mini-symposium on Natural Products and Drug Discovery; 2019 Apr 11-13; Belgrade, Serbia (2019):38,
https://hdl.handle.net/21.15107/rcub_ibiss_4370 .

TY  - CONF
AU  - Stojković, Dejan
AU  - Ivanov, Marija
AU  - Petrović, Jovana
AU  - Kostić, Marina
AU  - Ćirić, Ana
AU  - Glamočlija, Jasmina
AU  - Soković, Marina
PY  - 2019
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4367
AB  - Diabetes mellitus is a chronic disorder of metabolism followed by abnormal rise in 
plasma glucose levels, as a consequence of unequilibrated insulin production and/or 
insensitivity to the effect of this hormone in signal transduction of cellular receptors. 
One of the effective strategies for diabetes type-2 management is the inhibition of 
complex polysaccharide hydrolysis by pancreatic α-amylase and absorption limitation 
of glucose by inhibiting intestinal α-glucosidase enzyme. 
Agaricus blazei Murrill, Coprinus comatus (O.F.Müll.) Pers., Cordyceps militaris (L.) Fr., 
Inonotus obliquus (Ach. ex Pers.) Pilát, Morchella conica Pers. and Phellinus linteus Berk. 
& M.A. Curtis were investigated for their antidiabetic properties. In vitro assays on 
α-amylase and α-glucosidase enzyme inhibition were performed with methanolic 
extracts of the selected mushrooms. Furthermore, we calculated the necessary daily 
intake of mushroom extracts and dry mushroom powders based on the equivalent 
doses of therapeutic drug acarbose given to diabetic patients per day.
Our comparative study on enzyme inhibition showed that the most promising 
potential is ascribed to I. obliquus extract, while no inhibition of α-amylase was recorded 
with M. conica and C. militaris methanolic extract at the tested concentration. The lowest 
daily intake of mushroom powder was suggested for I. obliquus with the dose of 3 × 
1.148 g/day, while the highest was predicted for P. linteus 3 × 2.215 g/day. 
Although majority of previous studies showed in vivo antidiabetic potential of water 
and polysaccharidic mushroom extracts by different experimental approaches, our 
study is the first highlighting in vitro antidiabetic potential by inhibition of α-amylase 
and α-glucosidase with methanolic extracts; which makes the investigated species 
more promising for the diabetes type-2 treatment by another additional and different 
mechanism of action.
PB  - Belgrade: Institute for Biological Research "Siniša Stanković", University of Belgrade
C3  - The 2nd Balkans-China Mini-symposium on Natural Products and Drug Discovery; 2019 Apr 11-13; Belgrade, Serbia
T1  - Edible and medicinal fungi inhibit enzymes linked to diabetes type-2 therapy
SP  - 37
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_4367
ER  - 

@conference{
author = "Stojković, Dejan and Ivanov, Marija and Petrović, Jovana and Kostić, Marina and Ćirić, Ana and Glamočlija, Jasmina and Soković, Marina",
year = "2019",
abstract = "Diabetes mellitus is a chronic disorder of metabolism followed by abnormal rise in 
plasma glucose levels, as a consequence of unequilibrated insulin production and/or 
insensitivity to the effect of this hormone in signal transduction of cellular receptors. 
One of the effective strategies for diabetes type-2 management is the inhibition of 
complex polysaccharide hydrolysis by pancreatic α-amylase and absorption limitation 
of glucose by inhibiting intestinal α-glucosidase enzyme. 
Agaricus blazei Murrill, Coprinus comatus (O.F.Müll.) Pers., Cordyceps militaris (L.) Fr., 
Inonotus obliquus (Ach. ex Pers.) Pilát, Morchella conica Pers. and Phellinus linteus Berk. 
& M.A. Curtis were investigated for their antidiabetic properties. In vitro assays on 
α-amylase and α-glucosidase enzyme inhibition were performed with methanolic 
extracts of the selected mushrooms. Furthermore, we calculated the necessary daily 
intake of mushroom extracts and dry mushroom powders based on the equivalent 
doses of therapeutic drug acarbose given to diabetic patients per day.
Our comparative study on enzyme inhibition showed that the most promising 
potential is ascribed to I. obliquus extract, while no inhibition of α-amylase was recorded 
with M. conica and C. militaris methanolic extract at the tested concentration. The lowest 
daily intake of mushroom powder was suggested for I. obliquus with the dose of 3 × 
1.148 g/day, while the highest was predicted for P. linteus 3 × 2.215 g/day. 
Although majority of previous studies showed in vivo antidiabetic potential of water 
and polysaccharidic mushroom extracts by different experimental approaches, our 
study is the first highlighting in vitro antidiabetic potential by inhibition of α-amylase 
and α-glucosidase with methanolic extracts; which makes the investigated species 
more promising for the diabetes type-2 treatment by another additional and different 
mechanism of action.",
publisher = "Belgrade: Institute for Biological Research "Siniša Stanković", University of Belgrade",
journal = "The 2nd Balkans-China Mini-symposium on Natural Products and Drug Discovery; 2019 Apr 11-13; Belgrade, Serbia",
title = "Edible and medicinal fungi inhibit enzymes linked to diabetes type-2 therapy",
pages = "37",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_4367"
}

Stojković, D., Ivanov, M., Petrović, J., Kostić, M., Ćirić, A., Glamočlija, J.,& Soković, M.. (2019). Edible and medicinal fungi inhibit enzymes linked to diabetes type-2 therapy. in The 2nd Balkans-China Mini-symposium on Natural Products and Drug Discovery; 2019 Apr 11-13; Belgrade, Serbia
Belgrade: Institute for Biological Research "Siniša Stanković", University of Belgrade., 37.
https://hdl.handle.net/21.15107/rcub_ibiss_4367

Stojković D, Ivanov M, Petrović J, Kostić M, Ćirić A, Glamočlija J, Soković M. Edible and medicinal fungi inhibit enzymes linked to diabetes type-2 therapy. in The 2nd Balkans-China Mini-symposium on Natural Products and Drug Discovery; 2019 Apr 11-13; Belgrade, Serbia. 2019;:37.
https://hdl.handle.net/21.15107/rcub_ibiss_4367 .

Stojković, Dejan, Ivanov, Marija, Petrović, Jovana, Kostić, Marina, Ćirić, Ana, Glamočlija, Jasmina, Soković, Marina, "Edible and medicinal fungi inhibit enzymes linked to diabetes type-2 therapy" in The 2nd Balkans-China Mini-symposium on Natural Products and Drug Discovery; 2019 Apr 11-13; Belgrade, Serbia (2019):37,
https://hdl.handle.net/21.15107/rcub_ibiss_4367 .

TY  - JOUR
AU  - Ivanov, Marija
AU  - Kostić, Marina
AU  - Stojković, Dejan
AU  - Glamočlija, Jasmina
AU  - Soković, Marina
PY  - 2019
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4060
AB  - Flavonoids are polyphenolic compounds with already confirmed various health benefits. This review will shed light on flavonoids as potential antifungals in Candida albicans infections. C. albicans is an opportunistic pathogen able to cause serious health issues due to numerous virulence factors amplifying its pathogenicity. One of the most important virulence factors is Candida ability to form biofilms which are highly resistant to the treatment of antifungal drugs; making diminishing of this pathogen even more challenging. This review will focus on current knowledge on individual flavonoid compounds having the potential to deal with C. albicans in vitro, with special turn on antibiofilm potential and insight into the mode of action, where available. Majority of the commercial drugs for the treatment of candidiasis belong to azole class, so the activity of flavonoids will be compared with the activity of newly synthetized azole compounds, as well as with azole drugs that are already on the market as official therapeutics. This literature review will provide pros and cons for pushing future research towards exploring novel synthetic azoles or further examination of a wide pallet of natural flavonoids.
PB  - Bentham Science Publishers
T2  - Current Medicinal Chemistry
T1  - Could Flavonoids Compete with Synthetic Azoles in Diminishing Candida albicans Infections? A Comparative Review Based on In Vitro Studies
IS  - 14
VL  - 26
DO  - 10.2174/0929867325666180629133218
SP  - 2536
EP  - 2554
ER  - 

@article{
author = "Ivanov, Marija and Kostić, Marina and Stojković, Dejan and Glamočlija, Jasmina and Soković, Marina",
year = "2019",
abstract = "Flavonoids are polyphenolic compounds with already confirmed various health benefits. This review will shed light on flavonoids as potential antifungals in Candida albicans infections. C. albicans is an opportunistic pathogen able to cause serious health issues due to numerous virulence factors amplifying its pathogenicity. One of the most important virulence factors is Candida ability to form biofilms which are highly resistant to the treatment of antifungal drugs; making diminishing of this pathogen even more challenging. This review will focus on current knowledge on individual flavonoid compounds having the potential to deal with C. albicans in vitro, with special turn on antibiofilm potential and insight into the mode of action, where available. Majority of the commercial drugs for the treatment of candidiasis belong to azole class, so the activity of flavonoids will be compared with the activity of newly synthetized azole compounds, as well as with azole drugs that are already on the market as official therapeutics. This literature review will provide pros and cons for pushing future research towards exploring novel synthetic azoles or further examination of a wide pallet of natural flavonoids.",
publisher = "Bentham Science Publishers",
journal = "Current Medicinal Chemistry",
title = "Could Flavonoids Compete with Synthetic Azoles in Diminishing Candida albicans Infections? A Comparative Review Based on In Vitro Studies",
number = "14",
volume = "26",
doi = "10.2174/0929867325666180629133218",
pages = "2536-2554"
}

Ivanov, M., Kostić, M., Stojković, D., Glamočlija, J.,& Soković, M.. (2019). Could Flavonoids Compete with Synthetic Azoles in Diminishing Candida albicans Infections? A Comparative Review Based on In Vitro Studies. in Current Medicinal Chemistry
Bentham Science Publishers., 26(14), 2536-2554.
https://doi.org/10.2174/0929867325666180629133218

Ivanov M, Kostić M, Stojković D, Glamočlija J, Soković M. Could Flavonoids Compete with Synthetic Azoles in Diminishing Candida albicans Infections? A Comparative Review Based on In Vitro Studies. in Current Medicinal Chemistry. 2019;26(14):2536-2554.
doi:10.2174/0929867325666180629133218 .

Ivanov, Marija, Kostić, Marina, Stojković, Dejan, Glamočlija, Jasmina, Soković, Marina, "Could Flavonoids Compete with Synthetic Azoles in Diminishing Candida albicans Infections? A Comparative Review Based on In Vitro Studies" in Current Medicinal Chemistry, 26, no. 14 (2019):2536-2554,
https://doi.org/10.2174/0929867325666180629133218 . .

TY  - JOUR
AU  - Stanković, Jovana
AU  - Novaković, Miroslav
AU  - Tešević, Vele
AU  - Ćirić, Ana
AU  - Soković, Marina
AU  - Zdunić, Gordana
AU  - Dajić-Stevanović, Zora
AU  - Gođevac, Dejan
PY  - 2019
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3613
AB  - This study was performed to determine the main antibacterial com­po­unds of the essential oil (ЕО) of saltmarsh plant Artemisia santonicum (Aster­aceae). The combination of HPTLC and direct bioautography was used for the activity guided isolation of isogeranic acid as the main antibacterial constituent with remarkable antimicrobial activity, although it was the minor component of the EO, present only in 0.2 %, as calculated from GC/FID. Its structure was deter­mined by 1D- and 2D-NMR and GC–MS techniques. Antibacterial acti­vity of isogeranic acid against all tested bacteria was significantly higher than EO and even than both controls streptomycin and ampicillin. In further inves­tigation of antibiofilm and antiquorum sensing activity EO exhibited the best inhibition of the biofilm formation at 1/8 minimal inhibitory concentration (MIC) and iso­geranic acid at 1/2 MIC. Both EO and isogeranic acid possessed pyocyanin inhibitory activity showing the reduction of pigment at 60.6 and 62.8 %, res­pect­ively, at 1/2 MIC concentrations.
T2  - Journal of the Serbian Chemical Society
T1  - HPTLC-direct bioautography-guided isolation of isogeranic acid as the main antibacterial constituent of Artemisia santonicum essential oil
IS  - 12
VL  - 84
DO  - 10.2298/jsc190513106s
SP  - 1355
EP  - 1365
ER  - 

@article{
author = "Stanković, Jovana and Novaković, Miroslav and Tešević, Vele and Ćirić, Ana and Soković, Marina and Zdunić, Gordana and Dajić-Stevanović, Zora and Gođevac, Dejan",
year = "2019",
abstract = "This study was performed to determine the main antibacterial com­po­unds of the essential oil (ЕО) of saltmarsh plant Artemisia santonicum (Aster­aceae). The combination of HPTLC and direct bioautography was used for the activity guided isolation of isogeranic acid as the main antibacterial constituent with remarkable antimicrobial activity, although it was the minor component of the EO, present only in 0.2 %, as calculated from GC/FID. Its structure was deter­mined by 1D- and 2D-NMR and GC–MS techniques. Antibacterial acti­vity of isogeranic acid against all tested bacteria was significantly higher than EO and even than both controls streptomycin and ampicillin. In further inves­tigation of antibiofilm and antiquorum sensing activity EO exhibited the best inhibition of the biofilm formation at 1/8 minimal inhibitory concentration (MIC) and iso­geranic acid at 1/2 MIC. Both EO and isogeranic acid possessed pyocyanin inhibitory activity showing the reduction of pigment at 60.6 and 62.8 %, res­pect­ively, at 1/2 MIC concentrations.",
journal = "Journal of the Serbian Chemical Society",
title = "HPTLC-direct bioautography-guided isolation of isogeranic acid as the main antibacterial constituent of Artemisia santonicum essential oil",
number = "12",
volume = "84",
doi = "10.2298/jsc190513106s",
pages = "1355-1365"
}

Stanković, J., Novaković, M., Tešević, V., Ćirić, A., Soković, M., Zdunić, G., Dajić-Stevanović, Z.,& Gođevac, D.. (2019). HPTLC-direct bioautography-guided isolation of isogeranic acid as the main antibacterial constituent of Artemisia santonicum essential oil. in Journal of the Serbian Chemical Society, 84(12), 1355-1365.
https://doi.org/10.2298/jsc190513106s

Stanković J, Novaković M, Tešević V, Ćirić A, Soković M, Zdunić G, Dajić-Stevanović Z, Gođevac D. HPTLC-direct bioautography-guided isolation of isogeranic acid as the main antibacterial constituent of Artemisia santonicum essential oil. in Journal of the Serbian Chemical Society. 2019;84(12):1355-1365.
doi:10.2298/jsc190513106s .

Stanković, Jovana, Novaković, Miroslav, Tešević, Vele, Ćirić, Ana, Soković, Marina, Zdunić, Gordana, Dajić-Stevanović, Zora, Gođevac, Dejan, "HPTLC-direct bioautography-guided isolation of isogeranic acid as the main antibacterial constituent of Artemisia santonicum essential oil" in Journal of the Serbian Chemical Society, 84, no. 12 (2019):1355-1365,
https://doi.org/10.2298/jsc190513106s . .

TY  - JOUR
AU  - Ćirić, Ana
AU  - Kruljević, Ivana
AU  - Stojković, Dejan
AU  - Fernandes, Ângela
AU  - Barros, Lillian
AU  - Calhelha, Ricardo C.
AU  - Ferreira, Isabel C. F. R.
AU  - Soković, Marina
AU  - Glamočlija, Jasmina
PY  - 2019
UR  - http://xlink.rsc.org/?DOI=C9FO01900F
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3576
AB  - This study was oriented towards the investigation of the biological properties of three wild growing and edible Macrolepiota species (M. mastoidea, M. rhacodes and Macrolepiota procera) from Serbia. The results revealed that the mushrooms have a low caloric value; free sugars such as mannitol and trehalose were identified; oxalic and malic acids were predominant organic acids, while p-hydroxybenzoic and p-coumaric acids were identified as the main phenolic compounds. Also, they were a rich source of polyunsaturated fatty acids, which dominated over monounsaturated and saturated fatty acids. Three isoforms of tocopherols were identified and quantified: α-, β-, and δ-tocopherol. Regarding biological properties, all three species exhibited antioxidant potential, antimicrobial potential and cytotoxic activity within the different tumour cell lines tested. This study indicates that these species are indeed functional foods, due to the fact that they are edible, consumable and hold different pharmacological activities.
PB  - The Royal Society of Chemistry
T2  - Food & Function
T1  - Comparative investigation on edible mushrooms Macrolepiota mastoidea, M. rhacodes and M. procera: functional foods with diverse biological activities.
IS  - 12
VL  - 10
DO  - 10.1039/c9fo01900f
SP  - 7678
EP  - 7686
ER  - 

@article{
author = "Ćirić, Ana and Kruljević, Ivana and Stojković, Dejan and Fernandes, Ângela and Barros, Lillian and Calhelha, Ricardo C. and Ferreira, Isabel C. F. R. and Soković, Marina and Glamočlija, Jasmina",
year = "2019",
abstract = "This study was oriented towards the investigation of the biological properties of three wild growing and edible Macrolepiota species (M. mastoidea, M. rhacodes and Macrolepiota procera) from Serbia. The results revealed that the mushrooms have a low caloric value; free sugars such as mannitol and trehalose were identified; oxalic and malic acids were predominant organic acids, while p-hydroxybenzoic and p-coumaric acids were identified as the main phenolic compounds. Also, they were a rich source of polyunsaturated fatty acids, which dominated over monounsaturated and saturated fatty acids. Three isoforms of tocopherols were identified and quantified: α-, β-, and δ-tocopherol. Regarding biological properties, all three species exhibited antioxidant potential, antimicrobial potential and cytotoxic activity within the different tumour cell lines tested. This study indicates that these species are indeed functional foods, due to the fact that they are edible, consumable and hold different pharmacological activities.",
publisher = "The Royal Society of Chemistry",
journal = "Food & Function",
title = "Comparative investigation on edible mushrooms Macrolepiota mastoidea, M. rhacodes and M. procera: functional foods with diverse biological activities.",
number = "12",
volume = "10",
doi = "10.1039/c9fo01900f",
pages = "7678-7686"
}

Ćirić, A., Kruljević, I., Stojković, D., Fernandes, Â., Barros, L., Calhelha, R. C., Ferreira, I. C. F. R., Soković, M.,& Glamočlija, J.. (2019). Comparative investigation on edible mushrooms Macrolepiota mastoidea, M. rhacodes and M. procera: functional foods with diverse biological activities.. in Food & Function
The Royal Society of Chemistry., 10(12), 7678-7686.
https://doi.org/10.1039/c9fo01900f

Ćirić A, Kruljević I, Stojković D, Fernandes Â, Barros L, Calhelha RC, Ferreira ICFR, Soković M, Glamočlija J. Comparative investigation on edible mushrooms Macrolepiota mastoidea, M. rhacodes and M. procera: functional foods with diverse biological activities.. in Food & Function. 2019;10(12):7678-7686.
doi:10.1039/c9fo01900f .

Ćirić, Ana, Kruljević, Ivana, Stojković, Dejan, Fernandes, Ângela, Barros, Lillian, Calhelha, Ricardo C., Ferreira, Isabel C. F. R., Soković, Marina, Glamočlija, Jasmina, "Comparative investigation on edible mushrooms Macrolepiota mastoidea, M. rhacodes and M. procera: functional foods with diverse biological activities." in Food & Function, 10, no. 12 (2019):7678-7686,
https://doi.org/10.1039/c9fo01900f . .

TY  - JOUR
AU  - Kritsi, Eftichia
AU  - Matsoukas, Minos-Timotheos
AU  - Potamitis, Constantinos
AU  - Detsi, Anastasia
AU  - Ivanov, Marija
AU  - Soković, Marina
AU  - Zoumpoulakis, Panagiotis
PY  - 2019
UR  - https://www.mdpi.com/1420-3049/24/21/3853
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3510
AB  - The prevalence of invasive fungal infections has been dramatically increased as the size of the immunocompromised population worldwide has grown. Aspergillus fumigatus is characterized as one of the most widespread and ubiquitous fungal pathogens. Among antifungal drugs, azoles have been the most widely used category for the treatment of fungal infections. However, increasingly, azole-resistant strains constitute a major problem to be faced. Towards this direction, our study focused on the identification of compounds bearing novel structural motifs which may evolve as a new class of antifungals. To fulfil this scope, a combination of in silico techniques and in vitro assays were implemented. Specifically, a ligand-based pharmacophore model was created and served as a 3D search query to screen the ZINC chemical database. Additionally, molecular docking and molecular dynamics simulations were used to improve the reliability and accuracy of virtual screening results. In total, eight compounds, bearing completely different chemical scaffolds from the commercially available azoles, were proposed and their antifungal activity was evaluated using in vitro assays. Results indicated that all tested compounds exhibit antifungal activity, especially compounds 1, 2, and 4, which presented the most promising minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) values and, therefore, could be subjected to further hit to lead optimization.
T2  - Molecules
T1  - Novel Hit Compounds as Putative Antifungals: The Case of Aspergillus fumigatus
IS  - 21
VL  - 24
DO  - 10.3390/molecules24213853
SP  - 3853
ER  - 

@article{
author = "Kritsi, Eftichia and Matsoukas, Minos-Timotheos and Potamitis, Constantinos and Detsi, Anastasia and Ivanov, Marija and Soković, Marina and Zoumpoulakis, Panagiotis",
year = "2019",
abstract = "The prevalence of invasive fungal infections has been dramatically increased as the size of the immunocompromised population worldwide has grown. Aspergillus fumigatus is characterized as one of the most widespread and ubiquitous fungal pathogens. Among antifungal drugs, azoles have been the most widely used category for the treatment of fungal infections. However, increasingly, azole-resistant strains constitute a major problem to be faced. Towards this direction, our study focused on the identification of compounds bearing novel structural motifs which may evolve as a new class of antifungals. To fulfil this scope, a combination of in silico techniques and in vitro assays were implemented. Specifically, a ligand-based pharmacophore model was created and served as a 3D search query to screen the ZINC chemical database. Additionally, molecular docking and molecular dynamics simulations were used to improve the reliability and accuracy of virtual screening results. In total, eight compounds, bearing completely different chemical scaffolds from the commercially available azoles, were proposed and their antifungal activity was evaluated using in vitro assays. Results indicated that all tested compounds exhibit antifungal activity, especially compounds 1, 2, and 4, which presented the most promising minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) values and, therefore, could be subjected to further hit to lead optimization.",
journal = "Molecules",
title = "Novel Hit Compounds as Putative Antifungals: The Case of Aspergillus fumigatus",
number = "21",
volume = "24",
doi = "10.3390/molecules24213853",
pages = "3853"
}

Kritsi, E., Matsoukas, M., Potamitis, C., Detsi, A., Ivanov, M., Soković, M.,& Zoumpoulakis, P.. (2019). Novel Hit Compounds as Putative Antifungals: The Case of Aspergillus fumigatus. in Molecules, 24(21), 3853.
https://doi.org/10.3390/molecules24213853

Kritsi E, Matsoukas M, Potamitis C, Detsi A, Ivanov M, Soković M, Zoumpoulakis P. Novel Hit Compounds as Putative Antifungals: The Case of Aspergillus fumigatus. in Molecules. 2019;24(21):3853.
doi:10.3390/molecules24213853 .

Kritsi, Eftichia, Matsoukas, Minos-Timotheos, Potamitis, Constantinos, Detsi, Anastasia, Ivanov, Marija, Soković, Marina, Zoumpoulakis, Panagiotis, "Novel Hit Compounds as Putative Antifungals: The Case of Aspergillus fumigatus" in Molecules, 24, no. 21 (2019):3853,
https://doi.org/10.3390/molecules24213853 . .

TY  - JOUR
AU  - Aleksić, Milena
AU  - Stanisavljević, Danijela
AU  - Ivanov, Marija
AU  - Vasiljević, Perica
AU  - Stevanović, Milena
AU  - Soković, Marina
AU  - Stojković, Dejan
PY  - 2019
UR  - https://onlinelibrary.wiley.com/doi/abs/10.1111/aab.12532
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3444
AB  - Pyrimethanil, a synthetic fungicide widely used for the treatment of pre‐ and postharvest fungal diseases on different agricultural crops, was explored for its antifungal activity on different fungal strains. The effect of pyrimethanil on fungal ergosterol was tested by using Aspergillus niger as a model organism. Furthermore, it was investigated, if pyrimethanil can effectively reduce the appearance of Aspergillus rot in wounded cherry tomato fruits. The fungicide cytotoxic effect on different human cell lines was evaluated. In addition, its influence on cell proliferation was studied. A. niger was the most resistant fungal strain (MFC 1.88 μg μL−1) to the effect of pyrimethanil. Addition of ergosterol doubled the MFC on A. niger, indicating that the compound might interfere with ergosterol, main sterol of fungal cell membrane. Disease incidence of A. niger in wounded cherry tomato fruits was not detected with pyrimethanil treatment of 0.75 mg/wound. Some cytotoxic effects of pyrimethanil on human cell lines were recorded already at 50 ng μL−1, while the expression of Ki67 marker of proliferation was decreased with 150 ng μL−1. These results altogether indicate that pyrimethanil is effective in reducing various fungal pathogens, but further use of this fungicide should be reevaluated because of its cytotoxicity.
T2  - Annals of Applied Biology
T1  - Pyrimethanil: Between efficient fungicide against Aspergillus rot on cherry tomato and cytotoxic agent on human cell lines
IS  - 2
VL  - 175
DO  - 10.1111/aab.12532
SP  - 228
EP  - 235
ER  - 

@article{
author = "Aleksić, Milena and Stanisavljević, Danijela and Ivanov, Marija and Vasiljević, Perica and Stevanović, Milena and Soković, Marina and Stojković, Dejan",
year = "2019",
abstract = "Pyrimethanil, a synthetic fungicide widely used for the treatment of pre‐ and postharvest fungal diseases on different agricultural crops, was explored for its antifungal activity on different fungal strains. The effect of pyrimethanil on fungal ergosterol was tested by using Aspergillus niger as a model organism. Furthermore, it was investigated, if pyrimethanil can effectively reduce the appearance of Aspergillus rot in wounded cherry tomato fruits. The fungicide cytotoxic effect on different human cell lines was evaluated. In addition, its influence on cell proliferation was studied. A. niger was the most resistant fungal strain (MFC 1.88 μg μL−1) to the effect of pyrimethanil. Addition of ergosterol doubled the MFC on A. niger, indicating that the compound might interfere with ergosterol, main sterol of fungal cell membrane. Disease incidence of A. niger in wounded cherry tomato fruits was not detected with pyrimethanil treatment of 0.75 mg/wound. Some cytotoxic effects of pyrimethanil on human cell lines were recorded already at 50 ng μL−1, while the expression of Ki67 marker of proliferation was decreased with 150 ng μL−1. These results altogether indicate that pyrimethanil is effective in reducing various fungal pathogens, but further use of this fungicide should be reevaluated because of its cytotoxicity.",
journal = "Annals of Applied Biology",
title = "Pyrimethanil: Between efficient fungicide against Aspergillus rot on cherry tomato and cytotoxic agent on human cell lines",
number = "2",
volume = "175",
doi = "10.1111/aab.12532",
pages = "228-235"
}

Aleksić, M., Stanisavljević, D., Ivanov, M., Vasiljević, P., Stevanović, M., Soković, M.,& Stojković, D.. (2019). Pyrimethanil: Between efficient fungicide against Aspergillus rot on cherry tomato and cytotoxic agent on human cell lines. in Annals of Applied Biology, 175(2), 228-235.
https://doi.org/10.1111/aab.12532

Aleksić M, Stanisavljević D, Ivanov M, Vasiljević P, Stevanović M, Soković M, Stojković D. Pyrimethanil: Between efficient fungicide against Aspergillus rot on cherry tomato and cytotoxic agent on human cell lines. in Annals of Applied Biology. 2019;175(2):228-235.
doi:10.1111/aab.12532 .

Aleksić, Milena, Stanisavljević, Danijela, Ivanov, Marija, Vasiljević, Perica, Stevanović, Milena, Soković, Marina, Stojković, Dejan, "Pyrimethanil: Between efficient fungicide against Aspergillus rot on cherry tomato and cytotoxic agent on human cell lines" in Annals of Applied Biology, 175, no. 2 (2019):228-235,
https://doi.org/10.1111/aab.12532 . .

TY  - JOUR
AU  - Stanković, Jovana
AU  - Gođevac, Dejan
AU  - Tešević, Vele
AU  - Dajić-Stevanović, Zora
AU  - Ćirić, Ana
AU  - Soković, Marina
AU  - Novaković, Miroslav
PY  - 2019
UR  - http://pubs.acs.org/doi/10.1021/acs.jnatprod.8b00970
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3397
AB  - A new flavonoid glucoside derivative, patuletin 3 -O-(2- O-feruloyl)-β-d-glucuronopyranosyl-(1→2)-β-d-glucopyranoside, named atriplexin IV (1), and three new triterpenoid saponin derivatives, two sulfonylated, β-d-glucopyranosyl-3 -O-(2- O-sulfo-β-d-galactopyranosyl)-(1→2)-α-l-arabinopyranoside-30-alolean-12-en-28-oate (2), named atriplexogenin I, β-d-glucopyranosyl-3- O-(2- O-sulfo-β-d-galactopyranosyl)-(1→2)-α-l-arabinopyranoside)-30-hydroxyolean-12-en-28-oate (3), named atriplexogenin II, and β-d-glucopyranosyl-3 -O-(β-d-glucopyranosyl-(1→2)-β-d-galactopyranosyl-(1→2)-α-l-arabinopyranoside)-30-alolean-12-en-28-oate (4), named atriplexogenin III, were isolated by silica gel column and semipreparative HPLC chromatography from the n-butanol extract of the salt marsh plant Atriplex tatarica. In addition, two known secondary metabolites, patuletin3 -O-β-d-apiofuranosyl-(1‴→2″)-β-d-glucopyranoside (5) and patuletin 3 -O-5‴- O-feruloyl-β-d-apiofuranosyl-(1‴→2″)-β-d-glucopyranoside (6), were isolated for the first time from A. tatarica. The structures of the isolated compounds were elucidated by 1D and 2D NMR, HRESIMS, IR, and UV data. Antibacterial activity by the microdilution method and antibiofilm activity against P. aeruginosa were assessed. Compound 5 possesses significant antibacterial activity, while the most potent antibiofilm agent is compound 2.
PB  - American Chemical Society and American Society of Pharmacognosy
T2  - Journal of Natural Products
T1  - Antibacterial and Antibiofilm Activity of Flavonoid and Saponin Derivatives from Atriplex tatarica against Pseudomonas aeruginosa.
IS  - 6
VL  - 82
DO  - 10.1021/acs.jnatprod.8b00970
SP  - 1487
EP  - 1495
ER  - 

@article{
author = "Stanković, Jovana and Gođevac, Dejan and Tešević, Vele and Dajić-Stevanović, Zora and Ćirić, Ana and Soković, Marina and Novaković, Miroslav",
year = "2019",
abstract = "A new flavonoid glucoside derivative, patuletin 3 -O-(2- O-feruloyl)-β-d-glucuronopyranosyl-(1→2)-β-d-glucopyranoside, named atriplexin IV (1), and three new triterpenoid saponin derivatives, two sulfonylated, β-d-glucopyranosyl-3 -O-(2- O-sulfo-β-d-galactopyranosyl)-(1→2)-α-l-arabinopyranoside-30-alolean-12-en-28-oate (2), named atriplexogenin I, β-d-glucopyranosyl-3- O-(2- O-sulfo-β-d-galactopyranosyl)-(1→2)-α-l-arabinopyranoside)-30-hydroxyolean-12-en-28-oate (3), named atriplexogenin II, and β-d-glucopyranosyl-3 -O-(β-d-glucopyranosyl-(1→2)-β-d-galactopyranosyl-(1→2)-α-l-arabinopyranoside)-30-alolean-12-en-28-oate (4), named atriplexogenin III, were isolated by silica gel column and semipreparative HPLC chromatography from the n-butanol extract of the salt marsh plant Atriplex tatarica. In addition, two known secondary metabolites, patuletin3 -O-β-d-apiofuranosyl-(1‴→2″)-β-d-glucopyranoside (5) and patuletin 3 -O-5‴- O-feruloyl-β-d-apiofuranosyl-(1‴→2″)-β-d-glucopyranoside (6), were isolated for the first time from A. tatarica. The structures of the isolated compounds were elucidated by 1D and 2D NMR, HRESIMS, IR, and UV data. Antibacterial activity by the microdilution method and antibiofilm activity against P. aeruginosa were assessed. Compound 5 possesses significant antibacterial activity, while the most potent antibiofilm agent is compound 2.",
publisher = "American Chemical Society and American Society of Pharmacognosy",
journal = "Journal of Natural Products",
title = "Antibacterial and Antibiofilm Activity of Flavonoid and Saponin Derivatives from Atriplex tatarica against Pseudomonas aeruginosa.",
number = "6",
volume = "82",
doi = "10.1021/acs.jnatprod.8b00970",
pages = "1487-1495"
}

Stanković, J., Gođevac, D., Tešević, V., Dajić-Stevanović, Z., Ćirić, A., Soković, M.,& Novaković, M.. (2019). Antibacterial and Antibiofilm Activity of Flavonoid and Saponin Derivatives from Atriplex tatarica against Pseudomonas aeruginosa.. in Journal of Natural Products
American Chemical Society and American Society of Pharmacognosy., 82(6), 1487-1495.
https://doi.org/10.1021/acs.jnatprod.8b00970

Stanković J, Gođevac D, Tešević V, Dajić-Stevanović Z, Ćirić A, Soković M, Novaković M. Antibacterial and Antibiofilm Activity of Flavonoid and Saponin Derivatives from Atriplex tatarica against Pseudomonas aeruginosa.. in Journal of Natural Products. 2019;82(6):1487-1495.
doi:10.1021/acs.jnatprod.8b00970 .

Stanković, Jovana, Gođevac, Dejan, Tešević, Vele, Dajić-Stevanović, Zora, Ćirić, Ana, Soković, Marina, Novaković, Miroslav, "Antibacterial and Antibiofilm Activity of Flavonoid and Saponin Derivatives from Atriplex tatarica against Pseudomonas aeruginosa." in Journal of Natural Products, 82, no. 6 (2019):1487-1495,
https://doi.org/10.1021/acs.jnatprod.8b00970 . .

TY  - JOUR
AU  - Fernandes, Filipa
AU  - Pereira, Eliana
AU  - Ćirić, Ana
AU  - Soković, Marina
AU  - Calhelha, Ricardo C.
AU  - Barros, Lillian
AU  - Ferreira, Isabel C. F. R.
PY  - 2019
UR  - http://xlink.rsc.org/?DOI=C9FO00578A
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3386
AB  - Ocimum basilicum var. purpurascens (red rubin basil) is a basil variety rich in anthocyanin compounds, commonly used in the food industry as an aromatic plant. In this study, the nutritional and chemical compositions of red rubin basil leaves were analysed, as well as, the antimicrobial activity and hepatotoxicity of their hydroethanolic extract. Carbohydrates were the main macronutrients present, with glucose being the major free sugar. Quinic acid was the most abundant organic acid, while γ-tocopherol was the highest tocopherol isoform found. α-Linolenic acid was the major fatty acid of the twenty identified compounds. Regarding polyphenols, twenty-six molecules were identified (thirteen non-anthocyanin and thirteen anthocyanin compounds), with rosmarinic acid being the main non-anthocyanin molecule and cyanidin-3-(6,6'-di-p-coumaroyl)-sophoroside-5-glcucoside the most abundant anthocyanin. These compounds could be related to the antimicrobial activity observed in this study. Thus, this variety could be considered a good source of value added molecules for the food industry.
T2  - Food & Function
T1  - Ocimum basilicum var. purpurascens leaves (red rubin basil): a source of bioactive compounds and natural pigments for the food industry.
IS  - 6
VL  - 10
DO  - 10.1039/c9fo00578a
SP  - 3161
EP  - 3171
ER  - 

@article{
author = "Fernandes, Filipa and Pereira, Eliana and Ćirić, Ana and Soković, Marina and Calhelha, Ricardo C. and Barros, Lillian and Ferreira, Isabel C. F. R.",
year = "2019",
abstract = "Ocimum basilicum var. purpurascens (red rubin basil) is a basil variety rich in anthocyanin compounds, commonly used in the food industry as an aromatic plant. In this study, the nutritional and chemical compositions of red rubin basil leaves were analysed, as well as, the antimicrobial activity and hepatotoxicity of their hydroethanolic extract. Carbohydrates were the main macronutrients present, with glucose being the major free sugar. Quinic acid was the most abundant organic acid, while γ-tocopherol was the highest tocopherol isoform found. α-Linolenic acid was the major fatty acid of the twenty identified compounds. Regarding polyphenols, twenty-six molecules were identified (thirteen non-anthocyanin and thirteen anthocyanin compounds), with rosmarinic acid being the main non-anthocyanin molecule and cyanidin-3-(6,6'-di-p-coumaroyl)-sophoroside-5-glcucoside the most abundant anthocyanin. These compounds could be related to the antimicrobial activity observed in this study. Thus, this variety could be considered a good source of value added molecules for the food industry.",
journal = "Food & Function",
title = "Ocimum basilicum var. purpurascens leaves (red rubin basil): a source of bioactive compounds and natural pigments for the food industry.",
number = "6",
volume = "10",
doi = "10.1039/c9fo00578a",
pages = "3161-3171"
}

Fernandes, F., Pereira, E., Ćirić, A., Soković, M., Calhelha, R. C., Barros, L.,& Ferreira, I. C. F. R.. (2019). Ocimum basilicum var. purpurascens leaves (red rubin basil): a source of bioactive compounds and natural pigments for the food industry.. in Food & Function, 10(6), 3161-3171.
https://doi.org/10.1039/c9fo00578a

Fernandes F, Pereira E, Ćirić A, Soković M, Calhelha RC, Barros L, Ferreira ICFR. Ocimum basilicum var. purpurascens leaves (red rubin basil): a source of bioactive compounds and natural pigments for the food industry.. in Food & Function. 2019;10(6):3161-3171.
doi:10.1039/c9fo00578a .

Fernandes, Filipa, Pereira, Eliana, Ćirić, Ana, Soković, Marina, Calhelha, Ricardo C., Barros, Lillian, Ferreira, Isabel C. F. R., "Ocimum basilicum var. purpurascens leaves (red rubin basil): a source of bioactive compounds and natural pigments for the food industry." in Food & Function, 10, no. 6 (2019):3161-3171,
https://doi.org/10.1039/c9fo00578a . .

TY  - JOUR
AU  - Džamić, Ana M.
AU  - Mileski, Ksenija S.
AU  - Ćirić, Ana
AU  - Ristić, Mihailo S.
AU  - Soković, Marina
AU  - Marin, Petar D.
PY  - 2019
UR  - https://www.tandfonline.com/doi/full/10.1080/0972060X.2019.1611487
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3384
AB  - The main aim of this work was to determine the chemical composition of essential oil from aerial parts and to evaluate potential antimicrobial and antioxidant activities of essential oil and deodorized extracts of Helichrysum italicum. The gas chromatography-flame ionization detector (GC/FID) and gas chromatography-mass spectrometry (GC/MS) techniques revealed the highest amount of sesquiterpene hydrocarbons (37.88 %), with neryl-acetate (20.44 %), γ-curcumene (14.08 %) and trans-α-bergamotene (6.99 %) as the main components. Total phenolic contents of tested extracts were determined by Folin-Ciocalteau assay and gallic acid was used as a standard. The highest phenolic concentration was measured in deodorised aqueous extract. The radical scavenging activity of the samples was evaluated by means of DPPH radicals. In this test, deodorised aqueous extract possessed the highest antioxidant effect (IC50 = 0.35 mg/ml), followed by deodorized methanol extract, while essential oil had the lowest scavengin...
T2  - Journal of Essential Oil Bearing Plants
T2  - Journal of Essential Oil Bearing Plants
T1  - Essential Oil Composition, Antioxidant and Antimicrobial Properties of Essential Oil and Deodorized Extracts of Helichrysum italicum (Roth) G. Don
IS  - 2
VL  - 22
DO  - 10.1080/0972060X.2019.1611487
SP  - 493
EP  - 503
ER  - 

@article{
author = "Džamić, Ana M. and Mileski, Ksenija S. and Ćirić, Ana and Ristić, Mihailo S. and Soković, Marina and Marin, Petar D.",
year = "2019",
abstract = "The main aim of this work was to determine the chemical composition of essential oil from aerial parts and to evaluate potential antimicrobial and antioxidant activities of essential oil and deodorized extracts of Helichrysum italicum. The gas chromatography-flame ionization detector (GC/FID) and gas chromatography-mass spectrometry (GC/MS) techniques revealed the highest amount of sesquiterpene hydrocarbons (37.88 %), with neryl-acetate (20.44 %), γ-curcumene (14.08 %) and trans-α-bergamotene (6.99 %) as the main components. Total phenolic contents of tested extracts were determined by Folin-Ciocalteau assay and gallic acid was used as a standard. The highest phenolic concentration was measured in deodorised aqueous extract. The radical scavenging activity of the samples was evaluated by means of DPPH radicals. In this test, deodorised aqueous extract possessed the highest antioxidant effect (IC50 = 0.35 mg/ml), followed by deodorized methanol extract, while essential oil had the lowest scavengin...",
journal = "Journal of Essential Oil Bearing Plants, Journal of Essential Oil Bearing Plants",
title = "Essential Oil Composition, Antioxidant and Antimicrobial Properties of Essential Oil and Deodorized Extracts of Helichrysum italicum (Roth) G. Don",
number = "2",
volume = "22",
doi = "10.1080/0972060X.2019.1611487",
pages = "493-503"
}

Džamić, A. M., Mileski, K. S., Ćirić, A., Ristić, M. S., Soković, M.,& Marin, P. D.. (2019). Essential Oil Composition, Antioxidant and Antimicrobial Properties of Essential Oil and Deodorized Extracts of Helichrysum italicum (Roth) G. Don. in Journal of Essential Oil Bearing Plants, 22(2), 493-503.
https://doi.org/10.1080/0972060X.2019.1611487

Džamić AM, Mileski KS, Ćirić A, Ristić MS, Soković M, Marin PD. Essential Oil Composition, Antioxidant and Antimicrobial Properties of Essential Oil and Deodorized Extracts of Helichrysum italicum (Roth) G. Don. in Journal of Essential Oil Bearing Plants. 2019;22(2):493-503.
doi:10.1080/0972060X.2019.1611487 .

Džamić, Ana M., Mileski, Ksenija S., Ćirić, Ana, Ristić, Mihailo S., Soković, Marina, Marin, Petar D., "Essential Oil Composition, Antioxidant and Antimicrobial Properties of Essential Oil and Deodorized Extracts of Helichrysum italicum (Roth) G. Don" in Journal of Essential Oil Bearing Plants, 22, no. 2 (2019):493-503,
https://doi.org/10.1080/0972060X.2019.1611487 . .

TY  - JOUR
AU  - Tratrat, Christophe
AU  - Haroun, Michelyne
AU  - Xenikakis, Iakovos
AU  - Liaras, Konstantinos
AU  - Tsolaki, Evangelia
AU  - Eleftheriou, Phaedra
AU  - Petrou, Anthi
AU  - Aldhubiab, Bandar
AU  - Attimarad, Mahesh
AU  - Venugopala, Katharigatta N.
AU  - Harsha, Sree
AU  - Elsewedy, Heba S.
AU  - Geronikaki, Athina
AU  - Soković, Marina
PY  - 2019
UR  - http://www.eurekaselect.com/169442/article
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3358
AB  - BACKGROUND Thiazole derivates as well as chalcones, are very important scaffold for medicinal chemistry. Literature survey revealed that they possess wide spectrum of biological activities among which are anti-inflammatory and antimicrobial. OBJECTIVES The current studies describe the synthesis and evaluation of antimicrobial activity of twenty eight novel thiazole-based chalcones. METHODS The designed compounds were synthesized using classical methods of organic synthesis. The in vivo evaluation of antimicrobial activity was performed by microdilution method. RESULTS All compounds have shown antibacterial properties better than that of ampicillin and in many cases better than streptomycin. As far as the antifungal activity is concerned, all compounds possess much higher activity than reference drugs bifonazole and ketoconazole. The most sensitive bacterial species was B. cereus (MIC 6.5-28.4 µmol × 10-2/mL and MBC 14.2-105.0 µmol × 10-2/mL) while the most resistant ones were L. monocytogenes (MIC 21.4-113.6 µmol × 10-2/mL) and E. coli (MIC 10.7- 113.6 µmol × 10-2/mL) and MBC at 42.7-358.6 µmol × 10-2/mL and 21.4-247.2 µmol × 10-2/mL, respectively. All the compounds exhibited antibacterial activity against the three resistant strains, MRSA, P. aeruginosa and E.coli. with MIC and MBC in the range of 0.65-11.00 µmol/mL × 10-2 and 1.30-16.50 µmol/mL × 10-2. Docking studies were performed. CONCLUSION Twenty-eight novel thiazole-based chalcones were designed, synthesized and evaluated for antimicrobial activity. The results showed that these derivatives could be lead compounds in search of new potent antimicrobial agents. Docking studies indicated that DNA gyrase, GyrB and MurA inhibition may explain the antibacterial activity.
T2  - Current Topics in Medicinal Chemistry
T1  - Design, Synthesis, Evaluation of Antimicrobial Activity and Docking Studies of New Thiazole-based Chalcones.
IS  - 5
VL  - 19
DO  - 10.2174/1568026619666190129121933
SP  - 356
EP  - 375
ER  - 

@article{
author = "Tratrat, Christophe and Haroun, Michelyne and Xenikakis, Iakovos and Liaras, Konstantinos and Tsolaki, Evangelia and Eleftheriou, Phaedra and Petrou, Anthi and Aldhubiab, Bandar and Attimarad, Mahesh and Venugopala, Katharigatta N. and Harsha, Sree and Elsewedy, Heba S. and Geronikaki, Athina and Soković, Marina",
year = "2019",
abstract = "BACKGROUND Thiazole derivates as well as chalcones, are very important scaffold for medicinal chemistry. Literature survey revealed that they possess wide spectrum of biological activities among which are anti-inflammatory and antimicrobial. OBJECTIVES The current studies describe the synthesis and evaluation of antimicrobial activity of twenty eight novel thiazole-based chalcones. METHODS The designed compounds were synthesized using classical methods of organic synthesis. The in vivo evaluation of antimicrobial activity was performed by microdilution method. RESULTS All compounds have shown antibacterial properties better than that of ampicillin and in many cases better than streptomycin. As far as the antifungal activity is concerned, all compounds possess much higher activity than reference drugs bifonazole and ketoconazole. The most sensitive bacterial species was B. cereus (MIC 6.5-28.4 µmol × 10-2/mL and MBC 14.2-105.0 µmol × 10-2/mL) while the most resistant ones were L. monocytogenes (MIC 21.4-113.6 µmol × 10-2/mL) and E. coli (MIC 10.7- 113.6 µmol × 10-2/mL) and MBC at 42.7-358.6 µmol × 10-2/mL and 21.4-247.2 µmol × 10-2/mL, respectively. All the compounds exhibited antibacterial activity against the three resistant strains, MRSA, P. aeruginosa and E.coli. with MIC and MBC in the range of 0.65-11.00 µmol/mL × 10-2 and 1.30-16.50 µmol/mL × 10-2. Docking studies were performed. CONCLUSION Twenty-eight novel thiazole-based chalcones were designed, synthesized and evaluated for antimicrobial activity. The results showed that these derivatives could be lead compounds in search of new potent antimicrobial agents. Docking studies indicated that DNA gyrase, GyrB and MurA inhibition may explain the antibacterial activity.",
journal = "Current Topics in Medicinal Chemistry",
title = "Design, Synthesis, Evaluation of Antimicrobial Activity and Docking Studies of New Thiazole-based Chalcones.",
number = "5",
volume = "19",
doi = "10.2174/1568026619666190129121933",
pages = "356-375"
}

Tratrat, C., Haroun, M., Xenikakis, I., Liaras, K., Tsolaki, E., Eleftheriou, P., Petrou, A., Aldhubiab, B., Attimarad, M., Venugopala, K. N., Harsha, S., Elsewedy, H. S., Geronikaki, A.,& Soković, M.. (2019). Design, Synthesis, Evaluation of Antimicrobial Activity and Docking Studies of New Thiazole-based Chalcones.. in Current Topics in Medicinal Chemistry, 19(5), 356-375.
https://doi.org/10.2174/1568026619666190129121933

Tratrat C, Haroun M, Xenikakis I, Liaras K, Tsolaki E, Eleftheriou P, Petrou A, Aldhubiab B, Attimarad M, Venugopala KN, Harsha S, Elsewedy HS, Geronikaki A, Soković M. Design, Synthesis, Evaluation of Antimicrobial Activity and Docking Studies of New Thiazole-based Chalcones.. in Current Topics in Medicinal Chemistry. 2019;19(5):356-375.
doi:10.2174/1568026619666190129121933 .

Tratrat, Christophe, Haroun, Michelyne, Xenikakis, Iakovos, Liaras, Konstantinos, Tsolaki, Evangelia, Eleftheriou, Phaedra, Petrou, Anthi, Aldhubiab, Bandar, Attimarad, Mahesh, Venugopala, Katharigatta N., Harsha, Sree, Elsewedy, Heba S., Geronikaki, Athina, Soković, Marina, "Design, Synthesis, Evaluation of Antimicrobial Activity and Docking Studies of New Thiazole-based Chalcones." in Current Topics in Medicinal Chemistry, 19, no. 5 (2019):356-375,
https://doi.org/10.2174/1568026619666190129121933 . .

TY  - JOUR
AU  - Jabeur, Inès
AU  - Pereira, Eliana
AU  - Caleja, Cristina
AU  - Calhelha, Ricardo C.
AU  - Soković, Marina
AU  - Catarino, Luís
AU  - Barros, Lillian
AU  - Ferreira, Isabel C. F. R.
PY  - 2019
UR  - http://xlink.rsc.org/?DOI=C9FO00287A
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3340
AB  - Different external factors influence the chemical characteristics of natural products, varying according to the geographic origin. The present study determined the nutritional and chemical composition of Hibiscus sabdariffa L. dried calyces (Guinea-Bissauan origin), as well as the phenolic composition, antioxidant, anti-inflammatory, cytotoxicity and antimicrobial activity of its infusion and hydroethanolic extracts. Among the chemical components, glucose and quinic acid showed the major concentration for sugars and organic acids, respectively. Palmitic acid and α-tocopherol were the most abundant lipophilic compounds. The individual phenolic compounds were analysed through HPLC-DAD-ESI/MS. Thirteen compounds were identified in the hydroethanolic extract, while twelve were identified in the infusion, 3-O-caffeoylquinic acid being the major non-anthocyanin compound. Three anthocyanins were identified, delphinidin-3-O-sambubioside being the most abundant. Both extracts showed promising results in all the bioactive assays. This study exhibited the beneficial properties of H. sabdariffa and also emphasized the potential applications of this plant in different industrial sectors.
T2  - Food & Function
T1  - Exploring the chemical and bioactive properties of Hibiscus sabdariffa L. calyces from Guinea-Bissau (West Africa).
IS  - 4
VL  - 10
DO  - 10.1039/c9fo00287a
SP  - 2234
EP  - 2243
ER  - 

@article{
author = "Jabeur, Inès and Pereira, Eliana and Caleja, Cristina and Calhelha, Ricardo C. and Soković, Marina and Catarino, Luís and Barros, Lillian and Ferreira, Isabel C. F. R.",
year = "2019",
abstract = "Different external factors influence the chemical characteristics of natural products, varying according to the geographic origin. The present study determined the nutritional and chemical composition of Hibiscus sabdariffa L. dried calyces (Guinea-Bissauan origin), as well as the phenolic composition, antioxidant, anti-inflammatory, cytotoxicity and antimicrobial activity of its infusion and hydroethanolic extracts. Among the chemical components, glucose and quinic acid showed the major concentration for sugars and organic acids, respectively. Palmitic acid and α-tocopherol were the most abundant lipophilic compounds. The individual phenolic compounds were analysed through HPLC-DAD-ESI/MS. Thirteen compounds were identified in the hydroethanolic extract, while twelve were identified in the infusion, 3-O-caffeoylquinic acid being the major non-anthocyanin compound. Three anthocyanins were identified, delphinidin-3-O-sambubioside being the most abundant. Both extracts showed promising results in all the bioactive assays. This study exhibited the beneficial properties of H. sabdariffa and also emphasized the potential applications of this plant in different industrial sectors.",
journal = "Food & Function",
title = "Exploring the chemical and bioactive properties of Hibiscus sabdariffa L. calyces from Guinea-Bissau (West Africa).",
number = "4",
volume = "10",
doi = "10.1039/c9fo00287a",
pages = "2234-2243"
}

Jabeur, I., Pereira, E., Caleja, C., Calhelha, R. C., Soković, M., Catarino, L., Barros, L.,& Ferreira, I. C. F. R.. (2019). Exploring the chemical and bioactive properties of Hibiscus sabdariffa L. calyces from Guinea-Bissau (West Africa).. in Food & Function, 10(4), 2234-2243.
https://doi.org/10.1039/c9fo00287a

Jabeur I, Pereira E, Caleja C, Calhelha RC, Soković M, Catarino L, Barros L, Ferreira ICFR. Exploring the chemical and bioactive properties of Hibiscus sabdariffa L. calyces from Guinea-Bissau (West Africa).. in Food & Function. 2019;10(4):2234-2243.
doi:10.1039/c9fo00287a .

Jabeur, Inès, Pereira, Eliana, Caleja, Cristina, Calhelha, Ricardo C., Soković, Marina, Catarino, Luís, Barros, Lillian, Ferreira, Isabel C. F. R., "Exploring the chemical and bioactive properties of Hibiscus sabdariffa L. calyces from Guinea-Bissau (West Africa)." in Food & Function, 10, no. 4 (2019):2234-2243,
https://doi.org/10.1039/c9fo00287a . .